Ibolya Bodnár, Boris Mravec, Lucia Kubovčáková, Erika Tóth, Ferenc Fülöp, Márton I.K. Fekete, Richard Květňanský, G. M. Nagy,
Prolactin is secreted from the anterior lobe of the pituitary gland in response both to suckling and to stress. We recently observed that 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), produced in the neurointermediate lobe of the pituitary gland, as well as in the medial basal hypothalamus, can selectively release prolactin from the anterior pituitary. Therefore, it has been proposed that salsolinol is a putative endogenous prolactin-releasing factor (PRF). Here, we report that ...
Tópico(s): Stress Responses and Cortisol
2004 - Wiley | Journal of Neuroendocrinology
Béla Tóth, Ibolya Bodnár, Krisztián Homicskó, Ferenc Fülöp, Márton I.K. Fekete, György M. Nagy,
We have recently observed that 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) produced by hypothalamic neurons can selectively release prolactin from the anterior lobe (AL) of the pituitary gland. Moreover, high affinity binding sites for SAL have been detected in areas, like median eminence (ME) and the neuro-intermediate lobe (NIL) that are known terminal fields of the tuberoinfundibular DAergic (TIDA) and tuberohypophysial (THDA)/periventricular (PHDA) DAergic systems of the hypothalamus, ...
Tópico(s): Neuropeptides and Animal Physiology
2002 - Elsevier BV | Neurotoxicology and Teratology
Krisztián Homicskó, István Kertész, B Radnai, Béla Tóth, G. P. Toth, Ferenc Fülöp, Márton I.K. Fekete, György M. Nagy,
It has been recently shown that salsolinol (SAL) is present in the hypothalamic neuroendocrine dopaminergic (NEDA) system and appears to be a selective and potent stimulator of prolactin (PRL) secretion in the rat. Furthermore, the lack of interference of SAL with 3H-spiperone binding in the striatum and the anterior lobe (AL) of the pituitary gland has been also demonstrated. These data clearly indicate that SAL does not act at the dopamine (DA) D2 receptors, and suggest that SAL supposedly has a binding ...
Tópico(s): Neuropeptides and Animal Physiology
2002 - Elsevier BV | Neurochemistry International
B Radnai, Boris Mravec, Ibolya Bodnár, Lucia Kubovčáková, Ferenc Fülöp, Márton I.K. Fekete, G. M. Nagy, Richard Květňanský,
A bstract : In mammals, the role of a prolactin‐releasing factor (PRF) in the acute changes of prolactin (PRL) secretion that usually occur after challenges (e.g., suckling stimulus or stress) of homeostasis has been suspected for a long time. We have recently observed that 1‐methyl‐6,7‐dihydroxy‐1,2,3,4‐tetrahydroisoquinoline, salsolinol (SAL), produced by the hypothalamus and the neuro‐intermediate lobe (NIL) of the pituitary gland, can selectively release PRL from the anterior lobe (AL). Moreover, binding ...
Tópico(s): Stress Responses and Cortisol
2004 - Wiley | Annals of the New York Academy of Sciences
György Tóth, László Pálfalvi, Zoltán Tibai, Levente Tokodi, J. A. Fülöp, Zsuzsanna Márton, Gábor Almási, János Hebling,
A tilted-pulse-front pumped terahertz pulse source is proposed for the generation of extremely high field single-cycle terahertz pulses. The very simple and compact source consists of a single crystal slab having a blazed reflection grating grooved in its back surface. Its further important advantages are the energy scalability and the symmetric THz beam profile. Generation of ∼50 MV/cm focused field with 10.8 mJ terahertz pulse energy is predicted for a 7 cm diameter LiNbO 3 crystal, if the pump ...
Tópico(s): Pulsed Power Technology Applications
2019 - Optica Publishing Group | Optics Express
Attila Marton, Attila Fülöp, Miklós Bán, Márk E. Hauber, Csaba Moskát,
Abstract To avoid mobbing attacks by their hosts during egg laying, some avian brood parasites have evolved traits to visually and/or acoustically resemble predator(s) of their hosts. Prior work established that reed warblers ( Acrocephalus scirpaceus ), a small host species of the brood parasitic common cuckoo ( Cuculus canorus ), delayed returning to the nest when confronted by either the calls of the female cuckoo or that of the predatory sparrowhawk ( Accipiter nisus ). It remains less clear, however, whether ...
Tópico(s): Animal Behavior and Reproduction
2021 - Wiley | Ethology
Dénes Grózner, Kinga M. Sulyok, Zsuzsa Kreizinger, Zsuzsanna Rónai, Szilárd Jánosi, Ibolya Turcsányi, Henrik Fülöp Károlyi, Áron Botond Kovács, Márton József Kiss, Dmitriy V. Volokhov, Miklós Gyuranecz,
Mycoplasma anatis, M. anseris, M. cloacale and M. sp. 1220 colonise geese and ducks, and could be associated with infections of avian respiratory and nervous systems, cause mild to severe inflammation of cloaca and genital tracts, and embryo lethality. Co-occurrence of these Mycoplasma species in waterfowl is frequently detected and the identification of these mycoplasmas to the species level at a regular microbiology laboratory is difficult due to their similar morphological, cultural and biochemical ...
Tópico(s): Herpesvirus Infections and Treatments
2019 - Public Library of Science | PLoS ONE
Attila Marton, Attila Fülöp, Katalin Ozogány, Csaba Moskát, Miklós Bán,
It is well known that avian brood parasites lay their eggs in the nests of other bird species, called hosts. It remains less clear, however, just how parasites are able to recognize their hosts and identify the exact location of the appropriate nests to lay their eggs in. While previous studies attributed high importance to visual signals in finding the hosts' nests (e.g. nest building activity or the distance and direct sight of the nest from vantage points used by the brood parasites), the role ...
Tópico(s): Wildlife Ecology and Conservation
2019 - Nature Portfolio | Scientific Reports
Csaba Moskát, Márk E. Hauber, Miklós Bán, Attila Fülöp, Nikoletta Geltsch, Attila Marton, Zoltán Elek,
Common cuckoos (Cuculus canorus) are best known for their simple two-note calls ("cu-coo"), which are uttered only by males during the breeding season. A previous playback study revealed that territorial males were more tolerant toward playbacks of the calls of familiar, neighbouring individuals than toward unfamiliar, stranger simulated intruders, exhibiting the classical "dear-enemy" phenomenon. Here we experimentally assessed whether the acoustic cues for familiarity recognition are encoded in the ...
Tópico(s): Animal Behavior and Reproduction
2018 - Elsevier BV | Behavioural Processes
László Pálfalvi, György Tóth, Levente Tokodi, Zsuzsanna Márton, J. A. Fülöp, Gábor Almási, János Hebling,
A hybrid-type terahertz pulse source is proposed for high energy terahertz pulse generation.It is the combination of the conventional tilted-pulse-front setup and a transmission stair-step echelon-faced nonlinear crystal with a period falling in the hundredmicrometer range.The most important advantage of the setup is the possibility of using plane parallel nonlinear optical crystal for producing good-quality, symmetric terahertz beam.Another advantage of the proposed setup is the significant reduction ...
Tópico(s): Superconducting and THz Device Technology
2017 - Optica Publishing Group | Optics Express
Zoltán Elek, Miklós Bán, Attila Fülöp, Attila Marton, Márk E. Hauber, Csaba Moskát,
Abstract The brood parasitic Common Cuckoo Cuculus canorus is best known for its two-note “cu-coo” call which is almost continuously uttered by male during the breeding season and can be heard across long distances in the field. Although the informative value of the cuckoo call was intensively investigated recently, it is still not clear whether call characteristic(s) indicate any of the phenotypic traits of the respective vocalising individuals. To fill this gap, we studied whether the call rate ...
Tópico(s): Animal Behavior and Reproduction
2021 - Springer Science+Business Media | Journal of Ornithology
Dorottya Kocsis, Szabina Horváth, Ágnes Kemény, Zsófia Varga‐Medveczky, Csaba I. Pongor, Rózsa Molnár, Anna Mihály, Daniel L. Farkas, Márton Bese Naszlady, András Fülöp, András Horváth, Balázs Rózsa, Erika Pintér, Rolland Gyulai, Franciska Erdő,
Psoriasis is a chronic inflammatory disease with unmet medical needs. To clarify potential therapeutic targets, different animal models have been developed. In the current study, imiquimod-induced psoriasiform dermatitis was used for monitoring the changes in skin thickness, transepidermal water loss, body weight, blood perfusion and drug permeability for a topical cream formulation of caffeine, both in wild type and in knock out mice. Morphological characterization of control and diseased tissues ...
Tópico(s): Advancements in Transdermal Drug Delivery
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Tópico(s): Catalytic Processes in Materials Science
1989 - Akadémiai Kiadó | Reaction Kinetics and Catalysis Letters
Béla Tóth, Krisztián Homicskó, B Radnai, W. Maruyama, Jamie E. DeMaria, Miklós Vecsernyés, Márton I.K. Fekete, Ferenc Fülöp, Makoto Naoi, M. E. Freeman, Géza Nagy,
Abstract The isolation and identification of a prolactin‐releasing factor (PRF) from the neuro‐intermediate lobe of the pituitary gland has been pursued for over a decade. Using high‐pressure liquid chromatography with electrochemical detection (HPLC‐ECD) and gas chromatography/mass spectrometry (GC/MS) (R)‐salsolinol (SAL) (a dopamine‐related stereo‐specific tetrahydroisoquinoline) was found to be present in neuro‐intermediate lobe as well as median eminence extracts of male, intact‐, and ovariectomized ...
Tópico(s): Receptor Mechanisms and Signaling
2001 - Wiley | Journal of Neuroendocrinology
Zs. Homoki, Zs. Déri, Naomi Fulop, Márton A. Kelemen, Júlia Kövendiné Kónyi, É.O. Laca, György Szabó, Á. Ugron, I Turai,
The unusually strong earthquake in Japan on 11 March 2011 and the following extreme tsunami caused enormous damage in the buildings of Fukushima Dai-ichi Nuclear Power Plant (NPP) situated on the Pacific coastline of Japan. The accident led to the release of a large amount of radioactive material into the environment. According to the measurements of the Radiological Monitoring and Data Acquisitions Network (RAMDAN) the radioactive plume reached Hungary on 24 March 2011. The main volatile fission ...
Tópico(s): Nuclear and radioactivity studies
2013 - EDP Sciences | Radioprotection
Lóránd Kiss, Márton Kardos, Csaba Vass, Ferenc Fülöp,
Because of their biological relevance, cyclic β-amino acids have generated increasing interest and had significant impact in drug research over the past two decades. Their preparation and further functionalization towards new types of molecular entities have received large interest in synthetic and medicinal chemistry. Various types of metathesis reactions, such as ring-opening (ROM), ring-closing (RCM), or cross metathesis (CM) are used widely for access to either alicyclic β-amino acids or other ...
Tópico(s): Synthesis and Catalytic Reactions
2018 - Thieme Medical Publishers (Germany) | Synthesis
Lóránd Kiss, Márton Kardos, Enikő Forró, Ferenc Fülöp,
Abstract Through the ring‐opening metathesis of norbornene or oxanorbornene β‐amino acids with ethylene in the presence of certain Ru catalysts, a facile and convenient stereocontrolled one‐step method was devised for the preparation of divinylated cispentacins and oxacyclic cispentacin stereoisomers with four chiral centres. The products are interesting scaffolds for peptide chemistry and for the synthesis of novel functionalised materials through olefinic bond transformations. The ring‐opening ...
Tópico(s): Asymmetric Synthesis and Catalysis
2015 - Wiley | European Journal of Organic Chemistry
Márton Kardos, Lóránd Kiss, Ferenc Fülöp,
Abstract A stereocontrolled approach to highly functionalized 3,4‐disubstituted azetidin‐2‐ones and β 2, 3 ‐amino acid derivatives from readily available cycloalkadienes was achieved. The syntheses involved 1,3‐dipolar cycloaddition of chlorosulfonyl isocyanate, followed by ring‐opening metathesis of the unsaturated bi‐ or tricyclic β‐lactams, and cross‐metathesis of the resulting divinyl‐substituted azetidinones. The substituted lactams were subsequently transformed by heteroring‐opening into the ...
Tópico(s): Synthesis and Catalytic Reactions
2015 - Wiley | Asian Journal of Organic Chemistry
Zsuzsanna Rajnai, Dóra Méhn, Erzsébet Beéry, Alper Okyar, Márton Jani, Gábor Tóth, Ferenc Fülöp, Francis Lévi, Péter Krajcsi,
Seliciclib, a cyclin-dependent kinase inhibitor, is a promising candidate to treat a variety of cancers. Pharmacokinetic studies have shown high oral bioavailability but limited brain exposure to the drug. This study shows that seliciclib is a high-affinity substrate of ATP-binding cassette B1 (ABCB1) because it activates the ATPase activity of the transporter with an EC 50 of 4.2 μM and shows vectorial transport in MDCKII-MDR1 cells, yielding an efflux ratio of 8. This interaction may be behind ...
Tópico(s): Cancer therapeutics and mechanisms
2010 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Edina Katalin Cseh, Gábor Veres, Márton Szentirmai, Nikolett Nánási, István Szatmári, Ferenc Fülöp, László Vécsei, Dénes Zádori,
The development of a validated method, applicable for the measurement of tryptophan (TRP) and serotonin (5-HT), and that of the neuroprotective branch of the kynurenine pathway from several different biological matrices, including mouse brain, is described. Following the spectral analysis of the metabolites, they were quantified with reversed-phase high-performance liquid chromatography (HPLC), using separate internal standards (ISs) for UV (3-nitro-L-tyrosine) and fluorescent (the newly utilized 4-hydroxyquinazoline- ...
Tópico(s): Mental Health Research Topics
2019 - Elsevier BV | Analytical Biochemistry
Annamária Fejes-Szabó, Zsuzsanna Bohár, Enikő Vámos, Gábor Nagy-Grócz, Lilla Tar, Gábor Veres, Dénes Zádori, Márton Szentirmai, János Tajti, István Szatmári, Ferenc Fülöp, József Toldi, Árpád Párdutz, László Vécsei,
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2014 - Springer Science+Business Media | Journal of Neural Transmission
Rimante Minkeviciene, Sylvain Rheims, Márton B. Dobszay, Misha Zilberter, Jarmo Hartikainen, Lívia Fülöp, Botond Penke, Yuri Zilberter, Tibor Harkany, Asla Pitkänen, Heikki Tanila,
Alzheimer's disease is associated with an increased risk of unprovoked seizures. However, the underlying mechanisms of seizure induction remain elusive. Here, we performed video-EEG recordings in mice carrying mutant human APPswe and PS1dE9 genes (APdE9 mice) and their wild-type littermates to determine the prevalence of unprovoked seizures. In two recording episodes at the onset of amyloid beta (Abeta) pathogenesis (3 and 4.5 months of age), at least one unprovoked seizure was detected in 65% of APdE9 ...
Tópico(s): Cellular transport and secretion
2009 - Society for Neuroscience | Journal of Neuroscience
Márton Kardos, Lóránd Kiss, Matti Haukka, Santos Fustero, Ferenc Fülöp,
Substituted cyclopentanes or tetrahydrofurans bearing two vinyl groups have been investigated in cross‐metathesis reactions to explore chemodiscrimination of the two olefin bonds. The syntheses consisted of ring opening of constrained unsaturated β‐lactams or bicyclic β‐amino acids, followed by cross‐metathesis to test the chemodifferentiation of the divinyl‐substituted azetidinones or β‐amino esters in the presence of various ruthenium‐based catalysts.
Tópico(s): Synthesis of β-Lactam Compounds
2017 - Wiley | European Journal of Organic Chemistry
Gábor Veres, Annamária Fejes-Szabó, Dénes Zádori, Gábor Nagy-Grócz, Anna László, A Bajtai, István M. Mándity, Márton Szentirmai, Zsuzsanna Bohár, Klaudia Laborc, István Szatmári, Ferenc Fülöp, László Vécsei, Árpád Párdutz,
Kynurenic acid (KYNA) has well-established protective properties against glutamatergic neurotransmission, which plays an essential role in the activation and sensitization process during some primary headache disorders. The goal of this study was to compare the effects of two KYNA analogs, N-(2-N,N-dimethylaminoethyl)-4-oxo-1H-quinoline-2-carboxamide hydrochloride (KA-1) and N-(2-N-pyrrolidinylethyl)-4-oxo-1H-quinoline-2-carboxamide hydrochloride (KA-2), in the orofacial formalin test of trigeminal ...
Tópico(s): Tryptophan and brain disorders
2016 - Springer Science+Business Media | Journal of Neural Transmission
Csaba Varga, Zsolt Kálmán, Alíz Szakáll, Kata Drubits, Márton Koch, Róbert János Bánhegyi, Tibor Oláh, Éva Pozsgai, Norbert Fülöp, József Betlehem,
In periarrest situations and during resuscitation it is essential to rule out reversible causes. Hyperkalemia is one of the most common, reversible causes of periarrest situations. Typical electrocardiogram (ECG) alterations may indicate hyperkalemia. The aim of our study was to compare the prevalence of ECG alterations suggestive of hyperkalemia in normokalemic and hyperkalemic patients. 170 patients with normal potassium (K+) levels and 135 patients with moderate (serum K+ = 6.0–7.0 mmol/l) or severe ( ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2019 - BioMed Central | BMC Emergency Medicine
Péter Degrell, Judit Cseh, Márton Mohás, G Molnár, László Pajor, John C. Chatham, Norbert Fülöp, István Wittmann,
There is increasing evidence that O-linked N-acetylglucosamine (O-GlcNAc) plays an important role in cell signaling pathways. It has also been reported that increases in O-GlcNAc contribute to the development of diabetes and diabetic complications; however, little is known about O-GlcNAc levels in diabetic nephropathy (DNP). Therefore the goal of this study was to determine whether O-GlcNAc could be detected in human kidney biopsy specimens, and if so to examine whether O-GlcNAc levels were increased ...
Tópico(s): Advanced Glycation End Products research
2009 - Elsevier BV | Life Sciences
Rebeka Mészáros, András Márton, Márton Szabados, Gábor Varga, Zoltán Kónya, Ákos Kukovecz, Ferenc Fülöp, István Pálinkó, Sándor B. Ötvös,
A silver-containing hybrid material is reported as a heterogeneous noble metal catalyst for protodecarboxylations and decarboxylative deuterations of carboxylic acids.
Tópico(s): Chemical Synthesis and Analysis
2021 - Royal Society of Chemistry | Green Chemistry
Márta Kotormán, L.M. Simon, Attila Borics, Márton Richárd Szabó, Kitti Szabó, Titanilla Szögi, Lívia Fülöp,
The formation of amyloid-like fibrils was studied by using the well-known serine protease trypsin as a model protein in the presence of ethanol as organic solvent. Trypsin forms amyloid-like fibrils in aqueous ethanol at pH = 7.0. The dye Congo red (CR) was used to detect the presence of amyloid-like fibrils in the samples. The binding of CR to fibrils led to an increase in absorption intensity and a red shift in the absorption band of CR. Thioflavin T (ThT) and 8-anilino-1- naphthalenesulfonic acid ( ...
Tópico(s): Protein Structure and Dynamics
2015 - Bentham Science Publishers | Protein and Peptide Letters
... intensity of great reed warbler hosts by A. Marton, A. Fülöp, M. Bán, M. E. Hauber and C. Moskát. ...
Tópico(s): Plant Taxonomy and Phylogenetics
2021 - Wiley | Ethology
Attila Fülöp, István Kovács, Emanuel Ștefan Baltag, Szilárd J. Daróczi, Andreea S. Dehelean, Luca A. Dehelean, Réka B. Kis, István Komáromi, Hana Latková, Tamás Miholcsa, Attila Nagy, Szilárd Z. Ölvedi, Tamás Papp, Attila K. Sándor, Róbert Zeitz, Márton A. Kelemen,
Capsule Using a new survey station network we report the highest number of migrating raptors and Black Storks ever recorded on Bosporus during the autumn migration period. Also, we show that migration occurs with similar intensities over the full length of the strait, but individual migration patterns differ for some species at a local scale.
Tópico(s): Species Distribution and Climate Change
2014 - Taylor & Francis | Bird Study