J.M. Haapala, Juho Kirs, O. Tapani Rämö,
... well as at least five granite stocks (Naissaare, Märjamaa and its Kloostri satellite, Taebla, Neeme, and Ereda) ... to coarsegrained, microcline-megacrystic, partly trachytoid biotite (in Märjamaa and Naissaare also with hornblende) granite, locally cut ... aplitic and microsyenitic dykes.As an exception, the Märjamaa stock is more differentiated and has an anomalously ... comparable with the less differentiated granitic phases.The Märjamaa granodiorite and the Abja quartz monzodiorite are enriched ...
Tópico(s): Geochemistry and Elemental Analysis
2004 - Estonian Academy Publishers | Proceedings of the Estonian Academy of Sciences Geology
Annukka Marjamaa, Chris Newton-Cheh, Kimmo Porthan, Antti Reunanen, Päivi Lahermo, Heikki Väänänen, Antti Jula, Hannu Karanko, Heikki Swan, L. Toivonen, Markku S. Nieminen, Matti Viitasalo, L. Peltonen, Lasse Oikarinen, Aarno Palotie, Kimmo Kontula, Veikko Salomaa,
Abstract. Objectives. QT interval prolongation is associated with increased risk of sudden cardiac death at the population level. As 30–40% of the QT‐interval variability is heritable, we tested the association of common LQTS and NOS1AP gene variants with QT interval in a Finnish population‐based sample. Methods. We genotyped 12 common LQTS and NOS1AP genetic variants in Health 2000, an epidemiological sample of 5043 Finnish individuals, using Sequenom MALDI‐TOF mass spectrometry. ECG parameters ...
Tópico(s): ECG Monitoring and Analysis
2009 - Wiley | Journal of Internal Medicine
Annukka Marjamaa, Päivi J. Laitinen-Forsblom, Annukka M. Lahtinen, Matti Viitasalo, Lauri Toivonen, Kimmo Kontula, Heikki Swan,
Abstract Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe inherited cardiac disorder caused by mutations predominantly in the ryanodine receptor ( RyR2 ) gene. We sought to identify mutations in genes affecting cardiac calcium cycling in patients with CPVT and in less typical familial exercise-related ventricular arrhythmias. Methods and Results We recruited 33 consecutive patients with frequent ventricular premature complexes (VPCs) without structural heart disease ...
Tópico(s): Cardiovascular Effects of Exercise
2009 - BioMed Central | BMC Medical Genetics
Annukka Marjamaa, Veikko Salomaa, Christopher Newton‐Cheh, Kimmo Porthan, Antti Reunanen, Hannu Karanko, Antti Jula, Päivi Lahermo, Heikki Väänänen, Lauri Toivonen, Heikki Swan, Matti Viitasalo, Markku S. Nieminen, Leena Peltonen, Lasse Oikarinen, Aarno Palotie, Kimmo Kontula,
Aims. Long QT syndrome (LQTS) is an inherited arrhythmia disorder with an estimated prevalence of 0.01%–0.05%. In Finland, four founder mutations constitute up to 70% of the known genetic spectrum of LQTS. In the present survey, we sought to estimate the actual prevalence of the founder mutations and to determine their effect sizes in the general Finnish population.Methods and results. We genotyped 6334 subjects aged≥30 years from a population cohort (Health 2000 study) for the four Finnish founder ...
Tópico(s): Receptor Mechanisms and Signaling
2009 - Informa | Annals of Medicine
Annukka Marjamaa, Päivi J. Laitinen-Forsblom, Anetta Wronska, Lauri Toivonen, Kimmo Kontula, Heikki Swan,
Catecholaminergic polymorphic ventricular tachycardia caused by mutations in the RyR2 gene manifests as severe arrhythmias, and may provide a candidate for sudden cardiac deaths.We screened 19 victims of SCD for mutations in the RyR2 gene by direct sequencing, and analyzed DNAs from available family members and from 300 controls. Medico-legal investigations were conducted by experienced pathologists. We performed resting ECG, cardiac ultrasonography, exercise stress test, epinephrine test and 24- ...
Tópico(s): Cardiovascular Effects of Exercise
2009 - Elsevier BV | International Journal of Cardiology
Kaisa Marjamaa, E. Kukkola, Kurt Fagerstedt,
Lignification is a cell wall fortifying process which occurs in xylem tissue in a scheduled manner during tissue differentiation. In this review, enzymes and the genes responsible for lignin biosynthesis have been studied with an emphasis on lignin polymerizing class III secretable plant peroxidases. Our aim is to understand the cell and molecular biology of the polymerization of lignin especially in tracheids and vessels of woody species but much of the experimental evidence comes from herbaceous ...
Tópico(s): Lignin and Wood Chemistry
2009 - Oxford University Press | Journal of Experimental Botany
Kaisa Marjamaa, Mikko Lehtonen, Taina Lundell, M. Toikka, Pekka Saranpää, Kurt Fagerstedt,
We examined the relationship between β-glucosidase and peroxidase activities and xylem lignification in the stems of Scots pine (Pinus sylvestris L.), Norway spruce (Picea abies (L.) Karst.) and silver birch (Betula pendula Roth) during the 1999 growing season. Examination of stem cross sections stained with safranin and Alcian blue for lignin and cellulose, respectively, indicated that radial growth of pine and spruce xylem began in late May, whereas the growth of birch xylem was initiated 2 weeks ...
Tópico(s): Bioenergy crop production and management
2003 - Oxford University Press | Tree Physiology
Mylène Aubertin‐Leheudre, Anja Koskela, Annukka Marjamaa, Herman Adlercreutz,
Abstract Alkylresorcinols (AR) could be good biomarkers of consumption of fiber-rich cereal products. The aim of this study was to examine the relationship between plasma ARs or urinary AR metabolites and cereal fiber intake in women consuming their habitual diet. Twenty-five postmenopausal and 31 premenopausal women were recruited. The subjects included also vegetarians (n = 20) to obtain a broad range of cereal intake. Dietary intake, plasma ARs, and urinary AR metabolites [3,5-dihydroxybenzoic acid ...
Tópico(s): Phytoestrogen effects and research
2008 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Riita Marjamaa, Anne Vakkuri, Olli Kirvelä,
Operating room (OR) is a cost‐intensive environment, and it should be managed efficiently. When improving efficiency, shortening case duration by parallel processing, training of the resident surgeons, the choice of anesthetic methods, effective scheduling, and monitoring of the overall OR performance are important. When redesigning the OR processes, changes should be given a clear target and the achieved results monitored and reported to everyone involved. Advanced, reliable, and easy to use information ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2008 - Wiley | Acta Anaesthesiologica Scandinavica
Riitta A. Marjamaa, Paulus Torkki, Eero Hirvensalo, Olli Kirvelä,
Tópico(s): Healthcare Technology and Patient Monitoring
2008 - Springer Science+Business Media | Health Care Management Science
Kurt Fagerstedt, E. Kukkola, Ville Koistinen, Junko Takahashi, Kaisa Marjamaa,
Abstract Class III secretable plant peroxidases occur as a large family of genes in plants with many functions and probable redundancy. In this review we are concentrating on the evidence we have on the catalysis of lignin polymerization by class III plant peroxidases present in the apoplastic space in the xylem of trees. Some evidence exists on the specificity of peroxidase isozymes in lignin polymerization through substrate specificity studies, from antisense mutants in tobacco and poplar and ...
Tópico(s): Plant Gene Expression Analysis
2010 - Wiley | Journal of Integrative Plant Biology
Kimmo Porthan, Annukka Marjamaa, Matti Viitasalo, Heikki Väänänen, Antti Jula, Lauri Toivonen, Markku S. Nieminen, Christopher Newton‐Cheh, Veikko Salomaa, Kimmo Kontula, Lasse Oikarinen,
Single-nucleotide polymorphisms (SNPs) in genes encoding cardiac ion channels and nitric oxide synthase-1 adaptor protein (NOS1AP) are associated with electrocardiographic (ECG) QT-interval duration, but the association of these SNPs with new, prognostically important ECG measures of ventricular repolarization is unknown.The purpose of this study was to examine the relationship of SNPs to ECG T-wave peak to T-wave end (TPE) interval and T-wave morphology parameters.We studied 5,890 adults attending ...
Tópico(s): Cardiac Arrhythmias and Treatments
2010 - Elsevier BV | Heart Rhythm
Anikó Várnai, Liisa Viikari, Kaisa Marjamaa, Matti Siika‐aho,
Tópico(s): Catalysis for Biomass Conversion
2010 - Elsevier BV | Bioresource Technology
Riitta A. Marjamaa, Olli Kirvelä,
Background: Managing the surgical process in the operating suite – often the most expensive unit in the hospital – is vital, yet challenging. While sensible management can improve efficiency, unclear managerial structures can hinder the optimal use of resources. Despite that, no previous data exists as to how the operating room management is organized and the performance monitored in our country. Methods: A survey was sent to chief anesthesiologists and head nurses of 103 surgery units of 60 public ...
Tópico(s): Healthcare Operations and Scheduling Optimization
2007 - Wiley | Acta Anaesthesiologica Scandinavica
Annukka M. Lahtinen, Eero Lehtonen, Annukka Marjamaa, Maija Kaartinen, Tiina Heliö, Kimmo Porthan, Lasse Oikarinen, Lauri Toivonen, Heikki Swan, Antti Jula, Leena Peltonen, Aarno Palotie, Veikko Salomaa, Kimmo Kontula,
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive myocardial disorder caused by mutations of desmosomal cell adhesion proteins. The prevalence of these variants in the general population is unknown.This study examined the spectrum and population prevalence of desmosomal mutations predisposing to ARVC in Finland.We screened 29 Finnish ARVC probands for mutations in the DSP, DSG2, and DSC2 genes. All Finnish-type ARVC-associated mutations, including those 3 previously identified ...
Tópico(s): Sports injuries and prevention
2011 - Elsevier BV | Heart Rhythm
Jenni Rahikainen, Saara Mikander, Kaisa Marjamaa, Tarja Tamminen, Angelos A. Lappas, Liisa Viikari, Kristiina Kruus,
Lignin-derived inhibition is a major obstacle restricting the enzymatic hydrolysis of cell wall polysaccharides especially with softwood lignocellulosics. Enzyme adsorption on lignin is suggested to contribute to the inhibitory effect of lignin. The interaction of cellulases with softwood lignin was studied in the present work with commercial Trichoderma reesei cellulases (Celluclast) and lignin-rich residues isolated from steam pretreated softwood (SPS) by enzymatic and acid hydrolysis. Both lignin ...
Tópico(s): Lignin and Wood Chemistry
2011 - Wiley | Biotechnology and Bioengineering
Annukka M. Lahtinen, Annukka Marjamaa, Heikki Swan, Kimmo Kontula,
Abstract Background Long QT syndrome (LQTS) is an inherited ion channel disorder manifesting with prolongation of the cardiac repolarization phase and severe ventricular arrhythmias. The common KCNE1 D85N potassium channel variant prolongs QT interval by inhibiting I Ks (KCNQ1) and I Kr (KCNH2) currents and is therefore a suitable candidate for a modifier gene in LQTS. Methods We studied the effect of D85N on age-, sex-, and heart rate-adjusted QT-interval duration by linear regression in LQTS patients ...
Tópico(s): Cardiac pacing and defibrillation studies
2011 - BioMed Central | BMC Medical Genetics
Annukka Marjamaa, Anita Hiippala, Bianca Arrhenius, Annukka M. Lahtinen, Kimmo Kontula, Lauri Toivonen, Juha-Matti Happonen, Heikki Swan,
Epinephrine Infusion in Diagnosis of CPVT. Introduction: A test involving intravenous infusion of epinephrine has been proposed as a method alternative to exercise stress test in diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT). We aimed at estimating the predictive value of intravenous epinephrine administration in CPVT patients with frequent exercise‐induced ventricular ectopy. Methods and Results: We recruited 81 subjects, including 25 CPVT‐linked ryanodine receptor 2 ( ...
Tópico(s): Cardiac Arrhythmias and Treatments
2011 - Wiley | Journal of Cardiovascular Electrophysiology
Johan Marjamaa, Riikka Tulamo, Usama Abo‐Ramadan, Harri Hakovirta, Juhana Frösén, Ossi Rahkonen, Mika Niemelä, Paul Börnstein, Risto Penttinen, Marko Kangasniemi,
Deletion of the majority of the first intron of the Col1a1 gene in mice leads to decreased type I collagen synthesis and content in the aortic wall. In 54% of cases, mice homozygous for the Col1a1 mutation die of thoracic hemorrhage by the age of 18 months. It is unknown whether the fatal bleeding results from an acute dissection of the aortic wall or a gradually developing dilatation of the medial layer prior to rupture. We optimized high-resolution MRI methods using a 4.7 T MR scanner to obtain ...
Tópico(s): Aortic Disease and Treatment Approaches
2006 - Wiley | Magnetic Resonance in Medicine
Kaisa Marjamaa, E. Kukkola, Taina Lundell, P. Karhunen, Pekka Saranpää, Kurt Fagerstedt,
We partially purified peroxidase isoform fractions from xylem extracts of a gymnosperm, Norway spruce (Picea abies (L.) Karst.), and an angiosperm, silver birch (Betula pendula Roth.), to determine the participation of xylem-localized peroxidases in polymerization of different types of lignin in vivo. Several peroxidase fractions varying in isoelectric point values from acidic to basic were tested for their ability to catalyze the oxidation of the monolignols coniferyl alcohol, sinapyl alcohol and ...
Tópico(s): Biochemical and biochemical processes
2006 - Oxford University Press | Tree Physiology
Kaisa Marjamaa, Kristiina Hildén, E. Kukkola, Mikko Lehtonen, Heidi Holkeri, Pekka Haapaniemi, Sanna Koutaniemi, Teemu H. Teeri, Kurt Fagerstedt, Taina Lundell,
Tópico(s): Biochemical and biochemical processes
2006 - Springer Science+Business Media | Plant Molecular Biology
Juhana Frösén, Johan Marjamaa, Marjukka Myllärniemi, Usama Abo‐Ramadan, Riikka Tulamo, Mika Niemelä, Juha Hernesniemi, Juha E. Jääskeläinen,
Endovascular occlusive therapy of human saccular cerebral artery aneurysms may fail because of thrombus recanalization and incomplete neointima formation. Bone marrow-derived progenitor cells may contribute to these processes, but their role in human saccular cerebral artery aneurysms and experimental aneurysm models remains unclear.Experimental saccular aneurysms were constructed from syngeneic thoracic aortas transplanted end-to-side to the abdominal aorta of Wistar rats (n = 14), C57/B6 mice (n = 13), ...
Tópico(s): Aortic aneurysm repair treatments
2006 - Lippincott Williams & Wilkins | Neurosurgery
K. Anikeev, M. Bogdan, R. DeMaat, W. Fedorko, H. Frisch, Kristan Allan Hahn, Mikko Hakala, P. Keener, Y. Kim, J. Kroll, S. Kwang, J. D. Lewis, C. Lin, T. Liu, F. Marjamaa, T. Mansikkala, C. Neu, S. Pitkanen, B. Reisert, V. Rusu, H. Sanders, M. J. Shochet, H. Stabenau, R. Van Berg, P. Wilson, D. Whiteson, P. Wittich,
We describe the new CDF Level 2 Trigger, which was commissioned during Spring 2005. The upgrade was necessitated by several factors that included increased bandwidth requirements, in view of the growing instantaneous luminosity of the Tevatron, and the need for a more robust system, since the older system was reaching the limits of maintainability. The challenges in designing the new system were interfacing with many different upstream detector subsystems, processing larger volumes of data at higher ...
Tópico(s): Particle Accelerators and Free-Electron Lasers
2006 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Nuclear Science
Franklin Dexter, Melinda Davis, Christoph B. Egger Halbeis, Riita Marjamaa, J. Marty, Catherine A. McIntosh, Yoshinori Nakata, Kokila Thenuwara, Tomohiro Sawa, Michael M. Vigoda,
Tópico(s): Minimally Invasive Surgical Techniques
2006 - Springer Science+Business Media | Journal of Anesthesia
Riitta A. Marjamaa, Paulus Torkki, Markus Torkki, Olli Kirvelä,
A patient tracking system is a promising tool for managing patient flow and improving efficiency in the operating room. Wireless location systems, using infrared or radio frequency transmitters, can automatically timestamp key events, thereby decreasing the need for manual data input. In this study, we measured the accuracy and precision of automatically documented timestamps compared with manual recording. Each patient scheduled for urgent surgery was given an active radio frequency/infrared transmitter. ...
Tópico(s): Hospital Admissions and Outcomes
2006 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Paulus Torkki, Riitta A. Marjamaa, Markus Torkki, Pentti Kallio, Olli Kirvelä,
Background Mean turnover times and the time spent in the operating room (OR) can be reduced by concurrent induction of anesthesia. Previous studies of anesthesia induction outside the OR have concentrated either on anesthesia-controlled time or turnover time. The goal of this study was to investigate the impact of an induction room model on the whole surgical process, its phases and delays between the phases, and the number of cases performed during the 7-h working day. Methods A prospective analysis ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2005 - Lippincott Williams & Wilkins | Anesthesiology
Pascal Matsakis, James M. Keller, Ozy Sjahputera, Johan Marjamaa,
Affine invariant descriptors have been widely used for recognition of objects regardless of their position, size, and orientation in space. Examples of color, texture, and shape descriptors abound in the literature. However, many tasks in computer vision require looking not only at single objects or regions in images but also at their spatial relationships. In an earlier work, we showed that the relative position of two objects can be quantitatively described by a histogram of forces. Here, we study ...
Tópico(s): Robotics and Sensor-Based Localization
2004 - IEEE Computer Society | IEEE Transactions on Pattern Analysis and Machine Intelligence
Heikki Swan, Mohamed‐Yassine Amarouch, Jaakko T. Leinonen, Annukka Marjamaa, Jan Kučera, Päivi J. Laitinen-Forsblom, Annukka M. Lahtinen, Aarno Palotie, Kimmo Kontula, Lauri Toivonen, Hugues Abriel, Elisabeth Widén,
Background— Over the past 15 years, a myriad of mutations in genes encoding cardiac ion channels and ion channel interacting proteins have been linked to a long list of inherited atrial and ventricular arrhythmias. The purpose of this study was to identify the genetic and functional determinants underlying exercise-induced polymorphic ventricular arrhythmia present in a large multigenerational family. Methods and Results— A large 4-generation family presenting with exercise-induced polymorphic ventricular ...
Tópico(s): Cardiovascular Effects of Exercise
2014 - Lippincott Williams & Wilkins | Circulation Cardiovascular Genetics
Serge Marbacher, Johan Marjamaa, Essam Abdelhameed, Juha Hernesniemi, Mika Niemelä, Juhana Frösén,
Experimental saccular aneurysm models are necessary for testing novel surgical and endovascular treatment options and devices before they are introduced into clinical practice. Furthermore, experimental models are needed to elucidate the complex aneurysm biology leading to rupture of saccular aneurysms. Several different kinds of experimental models for saccular aneurysms have been established in different species. Many of them, however, require special skills, expensive equipment, or special environments, ...
Tópico(s): Aortic Disease and Treatment Approaches
2014 - MyJOVE | Journal of Visualized Experiments
Juha R. Savinainen, Jayendra Z. Patel, Teija Parkkari, Dina Navia‐Paldanius, Joona J. T. Marjamaa, Tuomo Laitinen, Tapio Nevalainen, Jarmo T. Laitinen,
Background Human lymphocyte antigen B-associated transcript 5 (BAT5, also known as ABHD16A) is a poorly characterized 63 kDa protein belonging to the α/β-hydrolase domain (ABHD) containing family of metabolic serine hydrolases. Its natural substrates and biochemical properties are unknown. Methodology/Principal Findings Amino acid sequence comparison between seven mammalian BAT5 orthologs revealed that the overall primary structure was highly (≥95%) conserved. Activity-based protein profiling (ABPP) ...
Tópico(s): Immune Cell Function and Interaction
2014 - Public Library of Science | PLoS ONE