Irene Mademont‐Soler, Mel·lina Pinsach‐Abuin, Helena Riuró, Jesús Matés, Alexandra Pérez‐Serra, Mónica Coll, José Manuel Porres, Bernat del Olmo, Anna Iglesias, Elisabet Selga, Ferran Picó, Sara Pagans, Carles Ferrer‐Costa, Georgia Sarquella‐Brugada, Elena Arbelo, Sergi César, Josép Brugada, Òscar Campuzano, Ramón Brugada,
Brugada syndrome (BrS) is a form of cardiac arrhythmia which may lead to sudden cardiac death. The recommended genetic testing (direct sequencing of SCN5A) uncovers disease-causing SNVs and/or indels in ~20% of cases. Limited information exists about the frequency of copy number variants (CNVs) in SCN5A in BrS patients, and the role of CNVs in BrS-minor genes is a completely unexplored field.220 BrS patients with negative genetic results were studied to detect CNVs in SCN5A. 63 cases were also screened ...
Tópico(s): Viral Infections and Immunology Research
2016 - Public Library of Science | PLoS ONE
Òscar Campuzano, Anna Fernàndez-Falgueras, Georgia Sarquella‐Brugada, O. Londono Sanchez, Sergi César, Irene Mademont‐Soler, Catarina Allegue, Jesús Matés, Alexandra Pérez‐Serra, Mónica Coll, Mireia Alcalde, Anna Iglesias, Coloma Tirón, María Ángeles Gallego, Carles Ferrer‐Costa, Anna Hospital, C. Segura Escribano, Concha Dasí, Juan Carlos Borondo, J Castellà, Elena Arbelo, Jordi Medallo, Josép Brugada, Ramón Brugada,
Death from myocarditis requires the presence of myocardial inflammation, without any other structural heart disease, and is frequently associated with a viral infection [(1)][1]. We postulate that genetic defects in structural proteins cause the myocardium to become vulnerable and predisposed to
Tópico(s): RNA and protein synthesis mechanisms
2015 - Elsevier BV | Journal of the American College of Cardiology
Helena Riuró, Òscar Campuzano, Paola Berne, Elena Arbelo, Anna Iglesias, Alexandra Pérez‐Serra, Mònica Coll-Vidal, Sara Partemi, Irene Mademont‐Soler, Ferran Picó, Catarina Allegue, Antonio Oliva, Edward P. Gerstenfeld, Georgia Sarquella‐Brugada, Víctor Castro‐Urda, Ignacio Fernández Lozano, Lluı́s Mont, Josép Brugada, Fabiana S. Scornik, Ramón Brugada,
The heritable cardiovascular disorder long QT syndrome (LQTS), characterized by prolongation of the QT interval on electrocardiogram, carries a high risk of sudden cardiac death. We sought to add new data to the existing knowledge of genetic mutations contributing to LQTS to both expand our understanding of its genetic basis and assess the value of genetic testing in clinical decision-making. Direct sequencing of the five major contributing genes, KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2, was performed ...
Tópico(s): Cardiomyopathy and Myosin Studies
2014 - Springer Nature | European Journal of Human Genetics
Tiziano Serra, Mònica Ortiz-Hernández, Elisabeth Engel, Josep A. Planell, Melba Navarro,
Achieving high quality 3D-printed structures requires establishing the right printing conditions. Finding processing conditions that satisfy both the fabrication process and the final required scaffold properties is crucial. This work stresses the importance of studying the outcome of the plasticizing effect of PEG on PLA-based blends used for the fabrication of 3D-direct-printed scaffolds for tissue engineering applications. For this, PLA/PEG blends with 5, 10 and 20% (w/w) of PEG and PLA/PEG/bioactive ...
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2014 - Elsevier BV | Materials Science and Engineering C
Andrea Rocca, Sara Bravaccini, Emanuela Scarpi, Anita Mangia, Stella Petroni, Maurizio Puccetti, Laura Medri, Luigi Serra, Monica Ricci, Serenella Cerasoli, Nicoletta Biglia, Roberta Maltoni, Donata Casadei Giunchi, Lorenzo Gianni, A. Tienghi, Mario Brandi, Monica Faedi, P Sismondi, Angelo Paradiso, Rosella Silvestrini, Dino Amadori,
Tópico(s): Cancer Treatment and Pharmacology
2013 - Springer Science+Business Media | Breast Cancer Research and Treatment
Francesco Lamberti, Camilla Luni, Alessandro Zambon, Pier Andrea Serra, Monica Giomo, Nicola Elvassore,
Miniaturization in biological analyses has several advantages, such as sample volume reduction and fast response time. The integration of miniaturized biosensors within lab-on-a-chip setups under flow conditions is highly desirable, not only because it simplifies process handling but also because measurements become more robust and operator-independent. In this work, we study the integration of flow amperometric biosensors within a microfluidic platform when analyte concentration is indirectly measured. ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2012 - American Institute of Physics | Biomicrofluidics
Monica C. Serra, Ana Casas, Duarte Toubarro, Ana Barros, J. A. Teixeira,
Microbial production of hyaluronic acid (HA) is an area of research that has been gaining attention in recent years due to the increasing demand for this biopolymer for several industrial applications. Hyaluronic acid is a linear, non-sulfated glycosaminoglycan that is widely distributed in nature and is mainly composed of repeating units of N-acetylglucosamine and glucuronic acid. It has a wide and unique range of properties such as viscoelasticity, lubrication, and hydration, which makes it an ...
Tópico(s): Polysaccharides and Plant Cell Walls
2023 - Multidisciplinary Digital Publishing Institute | Molecules
Ramón Torres‐Cavanillas, Marc Morant‐Giner, Garin Escorcia‐Ariza, Julien Dugay, Josep Canet‐Ferrer, Sergio Tatay, Salvador Cardona‐Serra, Mónica Giménez‐Marqués, Marta Galbiati, Alicia Forment‐Aliaga, Eugenio Coronado,
In the past few years, the effect of strain on the optical and electronic properties of MoS2 layers has attracted particular attention as it can improve the performance of optoelectronic and spintronic devices. Although several approaches have been explored, strain is typically externally applied on the two-dimensional material. In this work, we describe the preparation of a reversible 'self-strainable' system in which the strain is generated at the molecular level by one component of a MoS2-based ...
Tópico(s): ZnO doping and properties
2021 - Nature Portfolio | Nature Chemistry
Ada Mescoli, Giangabriele Maffei, Gelsomina Pillo, Giuseppe Bortone, Stefano Marchesi, Elena Morandi, Andrea Ranzi, Francesca Rotondo, Stefania Serra, Monica Vaccari, Stefano Zauli Sajani, Maria Grazia Mascolo, Miriam N. Jacobs, Annamaria Colacci,
As the novel coronavirus disease sweeps across the world several speculations have been made on the role that atmospheric factors may have played on the different distribution of SARS-CoV-2 and on the epidemiological characteristics of COVID-19. Knowing the role that environmental factors play in influenza virus outbreaks, environmental pollution and, in particular, atmospheric airborne (PM) has been considered as a potential key factor in the spread and mortality of COVID-19. A possible role of ...
Tópico(s): COVID-19 Pandemic Impacts
2020 - Frontiers Media | Frontiers in Genetics
Gessica Serra, Monica Deiana, Jeremy P. E. Spencer, Giulia Corona,
Scope The aim of the present study was to investigate the ability of extra virgin olive oil (EVOO) polyphenols to counteract the proinflammatory effects induced by dietary and endogenous oxysterols in ex vivo immune cells. Methods and results Peripheral blood mononuclear cells (PBMCs), separated from the whole blood of healthy donors, were utilized and were stimulated with an oxysterols mixture, in the presence of physiologically relevant concentrations of the EVOO polyphenols, hydroxytyrosol, tyrosol, ...
Tópico(s): Macrophage Migration Inhibitory Factor
2017 - Wiley | Molecular Nutrition & Food Research
O. Londono Sanchez, Òscar Campuzano, Anna Fernàndez-Falgueras, Georgia Sarquella‐Brugada, Sergi César, Irene Mademont‐Soler, Jesús Matés, Alexandra Pérez‐Serra, Mónica Coll, Ferran Picó, Anna Iglesias, Coloma Tirón, Catarina Allegue, Esther Carro, María Ángeles Gallego, Carles Ferrer‐Costa, Anna Hospital, Narcís Bardalet, Juan Carlos Borondo, Albert Vingut, Elena Arbelo, Josép Brugada, J Castellà, Jordi Medallo, Ramón Brugada,
Sudden unexplained death may be the first manifestation of an unknown inherited cardiac disease. Current genetic technologies may enable the unraveling of an etiology and the identification of relatives at risk. The aim of our study was to define the etiology of natural deaths, younger than 50 years of age, and to investigate whether genetic defects associated with cardiac diseases could provide a potential etiology for the unexplained cases.Our cohort included a total of 789 consecutive cases (77. ...
Tópico(s): Cardiac pacing and defibrillation studies
2016 - Public Library of Science | PLoS ONE
Verónica Escurriol, Montserrat Cofán, Mercè Serra, Mònica Bulló, Josep Basora, Jordi Salas‐Salvadó, Dolores Corella, Itzíar Zazpe, Miguel Ángel Martínez‐González, Valentina Ruiz‐Gutiérrez, Ramón Estruch, Emilio Ros,
Tópico(s): Biochemical Analysis and Sensing Techniques
2009 - Springer Science+Business Media | European Journal of Nutrition
Adrian Vella, Gerlies Bock, Paula D. Giesler, Duane Burton, Denise Serra, Monica Ligueros Saylan, Carolyn F. Deacon, James E. Foley, Robert A. Rizza, Michael Camilleri,
The incretin hormone glucagon-like peptide-1 (GLP-1) retards gastric emptying and decreases caloric intake. It is unclear whether increased GLP-1 concentrations achieved by inhibition of the inactivating enzyme dipeptidyl peptidase-4 (DPP-4) alter gastric volumes and satiation in people with type 2 diabetes.In a double-blind, placebo-controlled crossover design, 14 subjects with type 2 diabetes received vildagliptin (50 mg bid) or placebo for 10 days in random order separated by a 2-week washout. On ...
Tópico(s): Pancreatic function and diabetes
2008 - Wiley | Clinical Endocrinology
Chiara Dalla Man, Gerlies Bock, Paula D. Giesler, Denise Serra, Monica Ligueros Saylan, James E. Foley, Michael Camilleri, Gianna Toffolo, Claudio Cobelli, Robert A. Rizza, Adrian Vella,
OBJECTIVE—The purpose of this study was to determine the mechanism by which dipeptidyl peptidase-4 inhibitors lower postprandial glucose concentrations. RESEARCH DESIGN AND METHODS—We measured insulin secretion and action as well as glucose effectiveness in 14 subjects with type 2 diabetes who received vildagliptin (50 mg b.i.d.) or placebo for 10 days in random order separated by a 3-week washout. On day 9 of each period, subjects ate a mixed meal. Insulin sensitivity (SI), glucose effectiveness, ...
Tópico(s): Peptidase Inhibition and Analysis
2008 - American Diabetes Association | Diabetes Care
Adrian Vella, Gerlies Bock, Paula D. Giesler, Duane Burton, Denise Serra, Monica Ligueros Saylan, Beth E. Dunning, James E. Foley, Robert A. Rizza, Michael Camilleri,
OBJECTIVE— We sought to determine whether alterations in meal absorption and gastric emptying contribute to the mechanism by which inhibitors of dipeptidyl peptidase-4 (DPP-4) lower postprandial glucose concentrations. RESEARCH DESIGN AND METHODS— We simultaneously measured gastric emptying, meal appearance, endogenous glucose production, and glucose disappearance in 14 subjects with type 2 diabetes treated with either vildaglipitin (50 mg b.i.d.) or placebo for 10 days using a double-blind, placebo- ...
Tópico(s): Neuropeptides and Animal Physiology
2007 - American Diabetes Association | Diabetes
M. Chaffai, Pedro Serra, Mónica Gandía, Carmen Hernández, N. Durán-Vila,
Tópico(s): Plant Virus Research Studies
2007 - Springer Science+Business Media | Archives of Virology
Maximilian Papi, Giovenzio Genestreti, Davide Tassinari, Paolo Lorenzini, Silvia Serra, Monica Ricci, E. Pasquini, Mario Nicolini, Elena Pasini, Emiliano Tamburini, Pier Paolo Fattori, Alberto Ravaioli,
Malignant pericardial mesothelioma is an uncommon variety of a primary malignant cardio-pericardial tumor and it is a highly lethal and fortunately rare cardiac neoplasm. The presentation of pericardial mesothelioma is aspecific and pathologically mesothelioma is not the most common among primary tumors of the pericardium. It is characterized by atypical solid growth of mesothelium with formation of atypical cavities surrounded by fibrous stroma. Antemortem diagnosis is difficult and distant metastases ...
Tópico(s): Sarcoma Diagnosis and Treatment
2005 - SAGE Publishing | Tumori Journal
Fernando Acevedo, Miquel Àngel Serra, Monica Ermolli, Libero Clerici, Olof Vesterberg,
It has been established in previous in vitro experiments with human HaCaT keratinocytes that nickel becomes cytotoxic at concentrations higher than 100 μM and that it is accumulated mainly in the cytosolic fraction (Ermolli et al., 2000). The aim of this work was to search possible biomarkers of metal insult, i.e. nickel-binding proteins or proteins differentially expressed in the cytosolic fraction of nickel-exposed cells (up to 1 mM nickel) as compared to controls. Cytosolic proteins were studied ...
Tópico(s): Cellular Mechanics and Interactions
2001 - Elsevier BV | Toxicology
Gianfranco Menestrina, Cecilia Pederzolli, Mauro Dalla Serra, Monica Bregante, Franco Gambale,
Tópico(s): Neuroscience and Neuropharmacology Research
1996 - Springer Science+Business Media | The Journal of Membrane Biology
P. Gou, Josep Comaposada, E. Serra, Mónica Albertí Corominas, Manel Poch, J. Arnau,
Abstract Abstract Fermented sausages are dried in artificial driers, where the air relative humidity (RH) and temperature (T) are controlled. On the basis of product evaluation, an expert manually readjusts the RH set points in a staggered form. The main drawbacks of this control system are the discontinuity of the product evaluation and the cost of the experts' training. This study proposes a system to readjust the set points of RH based on the theory of fuzzy sets. Two fuzzy control systems were ...
Tópico(s): Animal Nutrition and Physiology
2005 - Taylor & Francis | Drying Technology
Mateu Serra‐Prat, Mònica Papiol, J. P. Vico, Elísabet Palomera, X. Sist, Montserrat Cabré i Pairet,
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2016 - Elsevier BV | European Geriatric Medicine
Maite Pellicer-Chenoll, Xavier García‐Massó, José Morales, Pilar Serra‐Añó, Mònica Solana-Tramunt, Luís-Millán González, José L. Toca‐Herrera,
The relationship among physical activity, physical fitness and academic achievement in adolescents has been widely studied; however, controversy concerning this topic persists. The methods used thus far to analyse the relationship between these variables have included mostly traditional lineal analysis according to the available literature. The aim of this study was to perform a visual analysis of this relationship with self-organizing maps and to monitor the subject's evolution during the 4 years ...
Tópico(s): Physical Activity and Health
2015 - Oxford University Press | Health Education Research
Marta Guasch‐Ferré, Nancy Babió, Miguel A Martínez-González, Dolores Corella, Emilio Ros, Sandra Martín‐Peláez, Ramón Estruch, Fernando Arós, Enrique Gómez‐Gracia, Miquel Fiol, José Manuel Santos‐Lozano, Lluís Serra‐Majem, Mònica Bulló, Estefanía Toledo, Rocío Barragán, Montserrat Fitó, Alfredo Gea, Jordi Salas‐Salvadó,
Dietary fat quality and fat replacement are more important for cardiovascular disease (CVD) prevention than is total dietary fat intake.The aim was to evaluate the association between total fat intake and fat subtypes with the risk of CVD (myocardial infarction, stroke, or death from cardiovascular causes) and cardiovascular and all-cause death. We also examined the hypothetical effect of the isocaloric substitution of one macronutrient for another.We prospectively studied 7038 participants at high ...
Tópico(s): Diet and metabolism studies
2015 - Elsevier BV | American Journal of Clinical Nutrition
Mateu Serra‐Prat, Mònica Papiol, R. Monteis, Elísabet Palomera, Montserrat Cabré i Pairet,
The aim of this study was to investigate the relationship between plasma ghrelin levels and sarcopenia in elderly people.
Tópico(s): Diet and metabolism studies
2015 - Springer Science+Business Media | The journal of nutrition health & aging
Lorenzo M. Donini, Lluís Serra‐Majem, Mònica Bulló, Ángel Gil, Jordi Salas‐Salvadó,
An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the 'Save PDF' action button.
Tópico(s): Biochemical Analysis and Sensing Techniques
2015 - Cambridge University Press | British Journal Of Nutrition
María‐Carmen López de las Hazas, Judit Gil-Zamorano, Montserrat Cofán, Diana C. Mantilla-Escalante, Almudena García‐Ruiz, Lorena del Pozo‐Acebo, Óscar Pastor, María Yáñez‐Mó, Carla Mazzeo, Mercè Serra‐Mir, Mónica Doménech, Cinta Valls‐Pedret, Sujatha Rajaram, Joan Sabaté, Emilio Ros, Aleix Sala‐Vila, Alberto Dávalos,
Epidemiological studies and clinical trials support the association of nut consumption with a lower risk of prevalent non-communicable diseases, particularly cardiovascular disease. However, the molecular mechanisms underlying nut benefits remain to be fully described. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and play a pivotal role in health and disease. Exosomes are extracellular vesicles released from cells and mediate intercellular communication. Whether nut consumption ...
Tópico(s): RNA regulation and disease
2020 - Springer Science+Business Media | European Journal of Nutrition
Mary K. Downer, Miguel Ángel Martínez‐González, Alfredo Gea, Meir J. Stampfer, Julia Wärnberǵ, Miguel Ruíz-Canela, Jordi Salas‐Salvadó, Dolores Corella, Emilio Ros, Montserrat Fitó, Ramón Estruch, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra‐Majem, Mònica Bulló, José V. Sorlí, Miguel Ángel Muñoz, Antonio García‐Rodríguez, Mario Gutiérrez‐Bedmar, Enrique Gómez‐Gracia,
Substantial evidence suggests that consuming 1–2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline. In this study, we evaluated ...
Tópico(s): Fatty Acid Research and Health
2017 - BioMed Central | BMC Cardiovascular Disorders
Produção Nacional
Revisado por pares
Carla Patrícia Bejo Wolkers, Mônica Serra, Raphael E. Szawka, Elisabeth Criscuolo Urbinati,
This study evaluated the influence of dietary L‐tryptophan ( TRP ) supplementation on the time course of aggressive behaviour and on neuroendocrine and hormonal indicators in juvenile matrinxã Brycon amazonicus . Supplementation with TRP promoted a change in the fight pattern at the beginning of an interaction with an intruder, resulting in decreased aggressive behaviours during the first 20 min. The decrease in aggression did not persist throughout the interaction but increased at 3 and 6 h after the ...
Tópico(s): Reproductive biology and impacts on aquatic species
2013 - Wiley | Journal of Fish Biology
Produção Nacional
Revisado por pares
... particular: a notícia de um suposto aborto de Mônica Serra, esposa de um dos candidatos à presidência, entre ...
Tópico(s): Social Media and Politics
2012 - Instituto de Ciência Política da Universidade de Brasília | Revista Brasileira de Ciência Política
Produção Nacional
Revisado por pares
Carla Patrícia Bejo Wolkers, Mônica Serra, Márcio Aquio Hoshiba, Elisabeth Criscuolo Urbinati,
Tópico(s): Fish biology, ecology, and behavior
2011 - Springer Science+Business Media | Fish Physiology and Biochemistry