Andrew Robson, Janice Turner, Christina Hardyment, Mike Gerrard, Stella Shamoon, Paul D. Smith, James Hlder, Bel Mooney, Andrew Pierce, Tom Fort, Thair Shalkh, Patricia Davies, June M. Bastable, Ian Nathan, Adam Sherwin Media Reporter, Sarah Potter, Nigel Colborn, Dr Thomas Stuttaford and Suzi Godson, Jane MacQuitty, Jasper Rees, Tim De Lisle, Robert Thicknesse, David Rhys Jones, John Mulvey, Rose Mainwaring-Burton, Ivo Tennant, Clare Lazaro, Judy Graham and Tom Chesshyre, Paula Black, Denis Pereira Gray, Philip Howard, Hannah Betts, Mark Pilkington, Christine Seib, Joanna Bale, James Bone, Rachel Campbell-Johnston, Nic Hopkins, Clive Davis, Alison Kervin, Alexandra Frean Social Affairs Correspondent, Kate Reardon, Elizabeth Judge, Teresa James, Lucia Van Der Post, Gillian Harris Scotland Correspondent, Declan Buckley, Richard Lioyd Parry, Nigel Pitt, Alex Hawkes and Christine Seib, Michael Sellers, John Bungey, Abigall Rayner and Dan Sabbagh, Ablgall Rayner, Geoff Brown, Philippe Petit, Giles Coren, Andrew Norfolk, Alastair Campbell, John Thicknesse, Ben Webster Transport Correspondent, Pat Gibson, Paul Fitzpatrick, A. C. Grayling, Antonia Senior Insurance Correspondent, Howard Davies, Patience Wheatcroft Business Editor's Commentary, Philip Hensher, Rob Cassy, John Clarke, Steve Keenan, Katherine Swift, Richard Ford and Mark Henderson, Anthony Browne, Tom Bawden, Steve Bird, Ruth Gledhill, Rachel Holmes, Debra Craine, Guy Clapperton, Mike Pattenden, Richard Sharpe, Greg Watts, George Wedd, Joe Morgan, Grainne Gilmore, Tim Reid, Dr Jane Collins, Angela Jameson Industrial Correspondent, Mark Henderson, Dalya Alberge Arts Correspondent, Sain Pattenden, Richard Ford Home Correspondent, Jo Morris, Alan Hamilton, Robin Young, Steve Harries, Brandon Robshaw, Kirsty Gallacher, Roland Watson, Charlie Higson, Paul Mardles, Daniel McGrory and Ingrid Mansell, Ron Lewis, Matt Dickinson Chief Football Correspondent, David Charter, Tim Teeman, Derwent May, Caroline Merrell Banking Correspondent, Arwa Haider, Angela Jameson, Adam and Joe, Alex Hawkes and Mark Atherton, Tony Vaughan, Robert Burrow, Russell Kempson, Peter Paphides, Mary Gold, Tony Halpin Education Editor, Richard Cork, Oliver Kay, Stephen Anderton, Dom Antony Sutch, Elaine Monaghan and Jacqul Goddard, John Westerby, Lisa Armstrong, Rick Broadbent, Emilia Nikroo, Mark Henderson Science Correspondent, Holly Finn, Chris Power, Geoffrey Dean, Rob Wright, Elaine Monaghan, Kate Rollason, Andy Stephens Sports Book, David Powell Athletics Correspondent, Alf Alderson, Raymond Keene, Adam Sage, Matthew Pryor, Rod Liddle, Gordon Ramsay, Emilia Fox, Marcus Pakenham, Xan Rice, Joseph Leightley, Jeremy Page, Ray Duff, Neville Scott, Janine Di Giovanni, Trevor Grove, Bronwen Maddox, Clare Longrigg, Donald Stark, Angry Brigades, Chris Campling, Bill Sweetenham Director, Christopher Martin-Jenkins Chief Cricket Correspondent, Erica Wagner, Nick Hasell, Chloë Bryan-Brown, Bill Bloomfield, Alex Williamson, Jesse Jarnow, Thelonious Monk, Philip Merricks, Tom Dart, Julian Muscat, Nicole Swegley, Adam Fresco, Mike Mulvihill, Andrew Wingate, Nick Szczepanik, Anne Ashworth, Joanna Pitman, John Goodbody, James Doran, Giles Whittell, Alexandra Biair Education Correspondent, Robert Crampton, Craig Lord, Phillip Howard, Mel Webb, Julie Burchill, Matthew Parris, Anjana Ahuja, John Ashton, George Caulkin, Alan Franks, Jonathan Rendall, John Lister-Kaye, Ingrid Mansell, Michael Austin, Caitlin Moran, Victor P. Taylor, Iain Finlayson, Christine Wheeler, Ian Partridge, Helen Pridham, Ann Clwyd, Philipps Petit, Philippa Norman, Jim Wagg, Judy Graham, Michael Dynes, Simon Ostrovsky, John Goodbody and Lewis Smith, David Charter Chief Political Correspondent, Alison Gibson, Graham Searjeant, David Sinclair, Geoffrey Rowell, Armand D'Angour, John Naish, Gary Duncan Economics Correspondent, James Smith, Martin Waller, Michael Horsnell, Chris Ayres, Christopher Irvine, Mark Cocker, Carl Mortished International Business Editor, Mark Baldwin, Nigel Hawkes Health Editor, Sarah Butler, Anna Shepard, Benedict Nightingale, Darian Leader, Jonathan Meades, Stephen Dalton, Jill Crawshaw, Leo Lewis, David Powell, Anthony Browne Europe Correspondent, Tom Chesshyre, Paul Connolly, Bireli Lagrene, James Christopher, Tom Baxter, Fred Dellar, Simon Crompton, Nicholas Cowell, Alan Lee Racing Correspondent, Philip Howard and Alan Hamilton, Huw Beynon, Susannah Jowitt, Cath Urquhart Travel Editor, Jan Raath, Jenny Davey, Garry Jenkins, Gerard Baker us Editor, Sam Lister Health Correspondent, David Hill, Mary Janes, David Lister Ireland Correspondent,
... shine, Tom Baxter finds his voice and the MC5 rock on Garage Shystie Diamond in the Dirt ( ... Acoustic Feather & Stone (Columbia) Grolsch Summer Set Livewires MC5 Drome Nouvelle Vague Loungecore Nouvelle Vage (Peacefrog) Jazz ...
2004 - Gale Group | TDA
Jingxiang Bai, Arthur I. Cederbaum,
... the cytosol (C33 cells) and especially in mitochondria (mC5 cells) were more sensitive to TNF-α-induced ... TNF-α, with the highest activities found in mC5 cells. Sodium azide, an inhibitor of catalase, reduced the increased sensitivity of mC5 and C33 cells to TNF-α to the ... also decreased the elevated caspase-3 activity of mC5 cells. A pan-caspase inhibitor prevented the TNF- ... ATP levels, with higher levels in C33 and mC5 cells compared with Hp cells. TNF-α did not produce apoptosis in mC5 cells maintained in a low energy state. TNF- ...
Tópico(s): NF-κB Signaling Pathways
2000 - Elsevier BV | Journal of Biological Chemistry
Giles Smith, Andrew Robson, Amanda Andrews, Tim Adler, Jennifer (Stanesby) Moody, Matthew Syed, Harry Cummins, David Brown, Alex Watson (Lab) Chairman, Zahid Hussain, Keith Mason, Amanda Ursell, Simon Barnes, Robin Pagnamenta Energy and Environment Editor, Ed Cooke, Keith R. Mitchell (Con) Chairman, Mark Souster, Linda Tsang, Catherine Boyle, David Rose, Nicolette Jones, Michael Evans Defence Editor, Philip Howard, Hilary Finch, Camilla Cavendish, Christine Seib, David Chater, Ben Hoyle Arts Reporter, James Bone, Gabrielle Starkey, Patrick Kidd, Gráinne Gilmore Economics Correspondent, Amanda Andrews Media Business Correspondent, Sam Marlowe, Wendy Ide, Geoff Brown, Lucy Bannerman, Martin Samuel Chief Football Correspondent, Giles Coren, Ben Webster Transport Correspondent, Francis Elliott, R. C. Millar, Tom Bawden, Susan Taylor, Gary Jacob, Peter Stiff, Siobhan Kennedy Politics and Business Correspondent, Geoff Buckley, Angela Jameson Industrial Correspondent, John D. Hart, Anatole Kaletsky, Sean O'Neill Crime & Security Editor, Stephen Collins, Tim Teeman, Susan Thompson, Dr Anthony Millett, Rebecca Walker, Richard Hobson Deputy Cricket Correspondent, Edward Fennell, Suzy Jagger, Oliver Kay, Ross Clark, Peter Box (Lab) Chairman, Mark Henderson Science Editor, Neil Harman, Tom Baldwin, Ben Quinn, Sam Coates, David Robertson Business Correspondent, Ann Treneman, Sheera Frenkel, Rob Wright, Alex Spence, Edward Gorman Motor Racing Correspondent, Neil Harman Tennis Correspondent, Raymond Keene, Christine Buckley, Jack Aspinall, Jill Shortland (Lib Dem) Chairman, Sarah Campbell, Sean O'Neill, Heather Brooke, Valèrie Elliott Consumer Editor, Jeremy Page, Chris Campling, Bronwen Maddox, Jill Sherman, Lindsey Bareham, Damian Whitworth, Francesca Steele, Nick Hasell, Kevin Maher, Julian Muscat, Paul Simons, Adam Fresco, Mary Ann Sieghart, Philip Webster Political Editor, Jonathan Clayton, Sam Coates Chief Political Correspondent, Steve Hawkes, Kevin Eason Sports News Correspondent, Emily Ford, Harry Stewart, Matthew Parris, Arnold Thomson, Peter Riddell, David S. Smith (Con) Chairman, Ben MacIntyre, Mike Atherton, Mohammed Sawaf, Carly Chynoweth, Steve Backshall, Philip Webster, Tony North, John Naish, Mark Barber, Catherine Philp, Martin Waller, Chris Ayres, Lisa Verrico, Stephen Dalton, Richard Morrison, Frances Gibb, Bill Edgar, Tony Halpin, Alan Yentob, Adam Sherwin, Clare Dight, Chris Smyth, Owen Slot, Steve Hawkes Retail Correspondent, Olav Bjortomt, Mike Atherton Chief Cricket Correspondent, John Reynolds (Con) Chairman, Miles Costello, Jan Raath, Fiona Hamilton, Dr Pam Spurr, Tim Hammond,
... in the desert Theatre Black Watch Barbican Pop MC5 Primal Scream Festival Hall Opera Rusalka Grange Park ...
2008 - Gale Group | TDA
Diane Thiboutot, Aruntha Sivarajah, Kathryn L. Gilliland, Zhaoyuan Cong, Gary A. Clawson,
... receptor subtypes (MC-R) designated MC1-R through MC5-R have been cloned and characterized (Chhajlani and ... receptor.J Biol Chem. 1993: 15174-15179Google Scholar). MC5-R is the only receptor subtype for which ... Scopus (94) Google Scholar). Targeted disruption of the MC5-R in transgenic mice results in multiple exocrine ... Low M. Cone R. Exocrine gland dysfunction in MC5-R deficient mice: evidence for coordinated regulation of ... MC4-R RP, 3′-TTGGCGGAT-GGCACCAGTGCC-5′ and MC5-R (Genbank #U08353) FP, 5′-GAGGGCAACCTTTCAGGACC-3′ MC5- ...
Tópico(s): melanin and skin pigmentation
2000 - Elsevier BV | Journal of Investigative Dermatology
Fei Le, Frank C. Stomski, Joanna M. Woodcock, Angel F. López, Thomas J. Gonda,
... Cys-86 → Ala (Mc4) and Cys-91 → Ala (Mc5) mutations abolished both events. Here, we used these ... T cells expressing hIL-3Rα and Mc4 or Mc5 did not proliferate in hIL-3, whereas cells ... 3-stimulated hβc tyrosine phosphorylation. The Mc4 and Mc5 mutations substantially reduced, but did not abrogate, IL- ... selected cells was normal. In contrast, Mc4 and Mc5 showed a limited effect on activation of Erk1 ... Cys-86 → Ala (Mc4) and Cys-91 → Ala (Mc5) mutations abolished both events. Here, we used these ... T cells expressing hIL-3Rα and Mc4 or Mc5 did not proliferate in hIL-3, whereas cells ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2000 - Elsevier BV | Journal of Biological Chemistry
Simge Akbulut, Craig A. Byersdorfer, Christen P. Larsen, Sara L. Zimmer, Tom Humphreys, Benjamin L. Clarke,
The expression of melanocortin-5 receptor (MC5-R) mRNA and protein was characterized from isolated rat lymphocytes. The presence of MC5-R mRNA in spleen and thymus tissues was ... product was sequenced to confirm the identification of MC5-R. Tissues from lachrymal glands, adipose, adrenals, thymus, ... transblotted to a nitrocellulose membrane, and probed for MC5-R using anti-receptor rabbit antisera. Two different ... peptides representing epitopes found at the amino (αN-MC5-R) and the carboxyl termini (αC-MC5-R) ...
Tópico(s): melanin and skin pigmentation
2001 - Elsevier BV | Biochemical and Biophysical Research Communications
Naohito Hatta, Craig Dixon, Amanda Ray, Siôn R. Phillips, W.J. Cunliffe, Mike Dale, Carol Todd, Simon Meggit, Mark A. Birch‐Machin, Jonathan L. Rees,
... 8250Abstract Full Text PDF PubMed Google Scholar), and MC5-R (Gantz et al., 1994Gantz I. Shimoto Y. ... PubMed Scopus (791) Google Scholar). The role of MC5-R was until recently unclear. This receptor is ... a variety of exocrine glands. The role of MC5-R in sebaceous gland function in mice was ... J. Cone R.D. Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of ... Scholar, who, following targeted disruption of the murine MC5-R gene, noted defective water repulsion and coat ...
Tópico(s): Regulation of Appetite and Obesity
2001 - Elsevier BV | Journal of Investigative Dermatology
Xuefang Zhao, Qi Liang, Xuemei Song, Yan Zhang,
Probiotic Lactiplantibacillus plantarum MC5 produces large amounts of exopolysaccharides (EPS), and its use as a compound fermentor can greatly improve the quality of ... gain insight into the genomic characteristics of probiotic MC5 and reveal the relationship between its EPS biosynthetic ... and EPS biosynthesis-related gene clusters of strain MC5 based on its whole genome sequence. Finally, we ... tests on the monosaccharides and disaccharides that strain MC5 may metabolize.Genomic analysis showed that MC5 has ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2023 - Frontiers Media | Frontiers in Microbiology
Julien A. Sebag, Patricia M. Hinkle,
... has the opposite effect on the closely related MC5 receptor. In enzyme-linked immunosorbent assay and microscopy ... and targeted to the plasma membrane with MRAP. MC5 receptor was at the plasma membrane in the ... dimers were present at the plasma membrane, whereas MC5 receptor-MRAP dimers were intracellular. Both MC2 and MC5 receptors co-precipitated with MRAP. MRAP did not ... readily detectable with or without MRAP. In contrast, MC5 receptor homodimers were visible in the absence of ... of differentially tagged receptors confirmed that MRAP blocks MC5 receptor dimerization. The regions of MRAP required for ...
Tópico(s): Regulation of Appetite and Obesity
2009 - Elsevier BV | Journal of Biological Chemistry
... study evaluated the effects of probiotic Lactobacillus plantarum MC5 on the quality, antioxidant activity, and storage stability ... made with different proportions of probiotic L. plantarum MC5 and commercial starters. The yogurt samples’ rheological properties, ... 1:1 yogurt samples (supplemented with L. plantarum MC5) attained the highest EPS content (982.42 mg/ ... WHC) of yogurt samples supplemented with L. plantarum MC5 were significantly higher than those of the control ... of antioxidant activity revealed that yogurt samples containing MC5 starter significantly increased in DPPH, ABTS, OH, and ...
Tópico(s): Food composition and properties
2022 - Multidisciplinary Digital Publishing Institute | Foods
Panagiotis Liakos, E.M. Chambaz, Jean‐Jacques Feige, G. Defaye,
... the melanocortin receptor (MC-R) family, MC2 and MC5 are expressed in peripheral tissues. The receptor MC2 ( ... almost exclusively expressed in the adrenal cortex whereas MC5-R is expressed in several organs including the ... work was to study the spatial distribution of MC5-R among the different zones of the bovine ... reaction (RT-PCR) analysis and RNase protection assay, MC5-R was detected only in the glomerulosa zone ... by ACTH, alpha-MSH, or AII increased the MC5-R mRNA level in glomerulosa cells by factors ...
Tópico(s): Genetic and phenotypic traits in livestock
2000 - Elsevier BV | Molecular and Cellular Endocrinology
Panagiotis Liakos, E.M. Chambaz, Jean‐Jacques Feige, G. Defaye,
... hence considered to be the ACTH receptor. The MC5-receptor (MC5-R) binds ACTH and alpha-MSH and is ... this work was to study the sites of MC5-R expression in the bovine adrenal cortex and ... regulation of the expression of MC2-R and MC5-R in bovine adrenocortical cells in primary culture. Analysis of the expression of MC5-R was obtained by RT-PCR, using total ... glomerulosa and fasciculata zones of bovine adrenocortical tissue. MC5-R expression could be detected in RNA from ... In bovine adrenocortical cells in culture, ACTH stimulates MC5-R expression in the glomerulosa and fasciculata cells. ...
Tópico(s): Adipose Tissue and Metabolism
1998 - Taylor & Francis | Endocrine Research
William B. Sea, Philippe Choler, Jason Beringer, Richard Weinmann, Lindsay B. Hutley, R. Leuning,
... Spectroradiometer) collections 4.8 (MC4) and 5.0 (MC5) with ground-based measurements taken along a 900 ... timing in the annual variation in LAI from MC5 and biometric estimates at Howard Springs, near Darwin, ... days of the year. Estimates of LAI from MC5 were also compared with those obtained from the ... distribution of leaves. Linear regression of LAI from MC5 versus that using the clumping algorithm yielded a ... offset of +0.16 m2 m−2 by MC5. Overall, our results show considerable improvement of MC5 over MC4 LAI and good agreement between MC5 ...
Tópico(s): Plant Water Relations and Carbon Dynamics
2011 - Elsevier BV | Agricultural and Forest Meteorology
Joanne F. Murray, Joel D. Hahn, A. R. Kennedy, C Small, Stephen R. Bloom, Carrie Haskell‐Luevano, Clive W. Coen, Catherine Wilson,
... have shown a role for melanocortin‐5 receptors (MC5‐R) in the stimulatory action of MCH, so ... the involvement of both MCH1‐R and/or MC5‐R in mediating the actions of MCH on ... administration of antagonists for either MCH1‐R or MC5‐R. However, in the mPOA, the action of MCH was blocked only by the MC5‐R antagonist. LH release was stimulated by an agonist for MC5‐R injected into the rPOA or mPOA; this was blocked by the MC5‐R antagonist but not the MCH1‐R antagonist. These results indicate that both MCH1‐R and MC5‐R are involved in the central control of ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2005 - Wiley | Journal of Neuroendocrinology
Trinidad Montero‐Melendez, Hetal Patel, Michael Seed, Søren Nielsen, Thomas E. N. Jonassen, Mauro Perretti,
... yielding high affinity for MC1 and MC3 over MC5. AP214 displays tissue-protective effects against renal postreperfusion ... higher affinity for human MC1 and MC3 over MC5, for instance, with inhibition constants calculated from binding ... and CHO cells that express MC3, MC4, or MC5 were used to determine agonistic activity, testing AP214 ... cells, and 30 minutes at 22°C for MC5 cells. Accumulation of cAMP was expressed as a ... MSH was used as control specific agonist for MC5 cells. All the experiments were performed in triplicate. ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2011 - Elsevier BV | American Journal Of Pathology
... ACTH) receptor as well as the newly discovered MC5 receptor. Using RT-PCR and Northern blot hybridization, ... all adipose tissues examined in the mouse, whereas MC5 receptor mRNA was found in a subset of ... characterize the pharmacological properties of the MC2 and MC5 receptor sites in situ. The MC2 receptor exhibits ... site characterized in these cells is presumably the MC5 receptor, based on the observation that this is ... melanocortin receptor mRNA detected in these cells. The MC5 receptor in the 3T3-L1 adipocyte activated adenylyl ...
Tópico(s): Biochemical Analysis and Sensing Techniques
1996 - Oxford University Press | Endocrinology
Bruce A. Boston, Roger D. Cone,
... ACTH) receptor as well as the newly discovered MC5 receptor. Using RT-PCR and Northern blot hybridization, ... all adipose tissues examined in the mouse, whereas MC5 receptor mRNA was found in a subset of ... characterize the pharmacological properties of the MC2 and MC5 receptor sites in situ. The MC2 receptor exhibits ... site characterized in these cells is presumably the MC5 receptor, based on the observation that this is ... melanocortin receptor mRNA detected in these cells. The MC5 receptor in the 3T3-L1 adipocyte activated adenylyl ...
Tópico(s): Olfactory and Sensory Function Studies
1996 - Oxford University Press | Endocrinology
Joanne F. Murray, Adan, Walker, B I Baker, Thody, Nijenhuis, Yukitake, Wilson,
... but are consistent with an action via the MC5 subtype. Preputial glands, which express MC5 receptors, were also stimulated by MCH which is ... this idea. In HEK293 cells transfected with the MC5 receptor MCH increased the production of IP3. However, ... I 125 NDP‐MSH from cells transfected with MC5 receptors indicating that it was not acting as ... MCH may function as an agonist at the MC5 receptor, its stimulation of LH release is more ... MCH receptor that has common properties with the MC5 receptor.
Tópico(s): Biochemical Analysis and Sensing Techniques
2000 - Wiley | Journal of Neuroendocrinology
Xian Xin Zhang, Krzysztof E. Krakowiak, Guoping Xue, Jerald S. Bradshaw, Reed M. Izatt,
... that a cage-type compound, decamethylcucurbit[5]uril (MC5), shows very high selectivity for Pb2+ over alkali, ... ΔH, and ΔS values) for the interactions of MC5 with metal ions were determined at 25 °C ... The log K(H2O) value for protonation of MC5 was determined to be 9.56. Pb2+ forms both 1:1 and 2:1 (Pb2+/MC5) complexes in 50% formic acid/water and aqueous ... cations studied form only 1:1 complexes with MC5 in the 50% formic acid/water solution. However, ... solution for Sr2+, indicating that the stoichiometry of MC5 complexes in 50% formic acid and in aqueous ...
Tópico(s): Molecular Sensors and Ion Detection
2000 - American Chemical Society | Industrial & Engineering Chemistry Research
Jerry Ryan Holder, Fernanda F Marques, Zhimin Xiang, Rayna M. Bauzo, Carrie Haskell‐Luevano,
... melanocortin MC3 receptor, melanocortin MC4 receptor, and melanocortin MC5 receptor. The N-terminal "capping" groups consisted of ... nM) while only enhancing potency at the melanocortin MC5 receptor (EC50=0.8 nM) by 8-fold, ... 140 nM agonist EC50 value at the melanocortin MC5 receptor. This 3,3,3-triphenylpropionyl-His-d- ... a 100-fold selective agonist for the melanocortin MC5 receptor, versus the other melanocortin receptors studied herein, and is the first melanocortin MC5 receptor selective tetrapeptide derivative reported to date with ...
Tópico(s): melanin and skin pigmentation
2003 - Elsevier BV | European Journal of Pharmacology
José Miguel Cerdá‐Reverter, Maria Josep Agulleiro, Raúl Guillot, Elisa Sánchez, Rosa M. Ceinos, Josep Rotllant,
... adenylyl cyclase. Tetrapod species have five melanocortin (MC1–MC5) receptors. The number of receptors varies in fish, ... melanocortin receptors, with two copies of the melanocortin MC5 receptor, while pufferfish have 4 receptors with no melanocortin MC3 receptor and one copy of melanocortin MC5 receptor. Fish genomes also exhibit orthologue genes for ... responsible for reduced melanization. Both melanocortin MC4 and MC5 receptor are expressed in the hypothalamus, and central ... metabolism by acting at hepatic melanocortin MC2 and MC5 receptors. Both sea bass melanocortin MC1 and MC4 ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2011 - Elsevier BV | European Journal of Pharmacology
Wenbiao Chen, Michele A. Kelly, Ximena Opitz-Araya, Ruth E. Thomas, Malcolm J. Low, Roger D. Cone,
... for ACTH/MSH peptides, the melanocortin-5 receptor (MC5-R), suggested nonsteroidally mediated systemic effects of these peptides. Targeted disruption of the MC5-R produced mice with a severe defect in ... decreased production of sebaceous lipids. High levels of MC5-R was found in multiple exocrine tissues, including ... gland. These data show a requirement for the MC5-R in multiple exocrine glands for the production ...
Tópico(s): melanin and skin pigmentation
1997 - Cell Press | Cell
... lipolytic response to melanocortins, however. Recently, MC2 and MC5 receptor‐MRNA was found in both murine adipocytes ... characterize the pharmacological properties of both MC2 and MC5 receptors in situ . Both murine MC2 and MC5 receptors are functional in the adipocyte, although the MC5 receptor required high doses of α‐MSH to ... hypothesis that the murine MC2 receptor, not the MC5 receptor, mediates stress‐induced lipolysis via release of ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
1999 - Wiley | Annals of the New York Academy of Sciences
Jun Liang, Vasily Gvilava, Christian Jansen, Seçil Öztürk, Alex Spieß, Jingxiang Lin, Shanghua Xing, Yangyang Sun, Hao Wang, Christoph Janiak,
... the presence of decamethylcucurbit[5]uril ammonium chloride (MC5⋅2 NH4 Cl⋅4 H2 O) directly affords MC5@MIL-100(Fe) hybrid monoliths featuring hierarchical micro-, ... shaping are facilitated by a newly discovered Fe-MC5 flowing gel formed by mechanochemistry. The designed MC5@MIL-100(Fe) hybrid material with MC5 as active domains shows enhanced CH4 and lead( ...
Tópico(s): Crystallography and molecular interactions
2021 - Wiley | Angewandte Chemie International Edition
Li Zhang, Mike Anthonavage, Qiuling Huang, Wen‐Hwa Li, Magdalena Eisinger,
... and that targeted disruption of melanocortin 5 receptor (MC5‐R) can down‐regulate sebum output in mice. ... RT‐PCR showed a low level of human MC5‐R expression under serum‐free condition but a ... of treatment. Our data indicate that expression of MC5‐R correlates with sebocyte differentiation and suggest a regulatory role for MC5‐R in human sebaceous lipid production.
Tópico(s): Dermatology and Skin Diseases
2003 - Wiley | Annals of the New York Academy of Sciences
Nathalie Griffon, Virginie Mignon, Patricia Facchinetti, Jorge Díaz, J. Schwartz, Pierre Sokoloff,
... and expression of the rat fifth melanocortin receptor (MC5), starting from the dopamine D3 receptor sequence to screen a genomic DNA library. The MC5 comprises a sequence of 325 aminoacids, displaying 45- ... Biochem. Biophys. Res, Comm. 195, 866-873). The MC5, stably expressed in CHO cells, mediates increase in ... In addition, in situ hybridization studies show the MC5 expressed in the three layers of the adrenal ...
Tópico(s): Biochemical Analysis and Sensing Techniques
1994 - Elsevier BV | Biochemical and Biophysical Research Communications
Suchada Jongrungruangchok, Somboon Tanasupawat, Takuji Kudo,
Three actinomycete strains, MC5-1T, MC7-1 and R1-1, were isolated from soil samples collected in Thailand. Their taxonomic positions were determined ... gene sequences revealed a close relationship between strains MC5-1T, MC7-1 and R1-1 (99.8 % ... On the basis of the data presented, strain MC5-1T represents a novel species of the genus ... Micromonospora chaiyaphumensis is proposed. The type strain is MC5-1T (=KCTC 19332T=JCM 12873T=PCU 267T=TISTR ...
Tópico(s): Mycorrhizal Fungi and Plant Interactions
2008 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
Reda S. Saad, Patrick Cho, Yulin L. Liu, Jan F. Silverman,
... fixed, paraffin-embedded, and immunostained for EMA clone Mc5 and EMA clone E29. The positive rates for clone Mc5 were 14/20 (70%) for MM and 12/ ... RM. The sensitivity and specificity for EMA clone Mc5 were 70 and 40%, respectively. For EMA clone ... both RM and MM immunostained for EMA clone Mc5, indicating that it is not a reliable immunocytochemical ...
Tópico(s): Medical Imaging and Pathology Studies
2005 - Wiley | Diagnostic Cytopathology
Luke A. Noon, Adrian Clark, Peter King,
... MC2-R, melanocortin 2 receptor; ACTH, adrenocorticotropic hormone; MC5-R, melanocortin 5 receptor; SF-1, steroidogenic factor- ... MC2-R, melanocortin 2 receptor; ACTH, adrenocorticotropic hormone; MC5-R, melanocortin 5 receptor; SF-1, steroidogenic factor- ... revealed the presence of both the MC2 and MC5-R. However, a pharmacological analysis showed that the ... not possible to measure protein expression directly. Although MC5-R has also been shown to be expressed ...
Tópico(s): Regulation of Appetite and Obesity
2004 - Elsevier BV | Journal of Biological Chemistry
Daniela M. Dinulescu, Roger D. Cone,
... receptors (α-MSH for MC1-, MC3-, MC4-, and MC5-R and ACTH for MC2-R). Melanocortins are ... 74 nm), and a very weak antagonist at MC5-R (KI (app) = 12,000 ± 340 nm) (10. ... KI (app) = 6.4 ± 1.1 nm) and MC5-R (KI (app) = 1.16 ± 0.17 nm) ( ... receptors), very little inhibition is detected at the MC5-R, and virtually no activity is detected at ...
Tópico(s): Polysaccharides Composition and Applications
2000 - Elsevier BV | Journal of Biological Chemistry