Nicolas Schaad, Toshimichi Shinohara, THORU ABE, David C. Klein,
MEKA is an acidic 33-kilodalton phosphoprotein found in the retina and pineal gland. It is of ... of GTP-binding regulatory proteins (G proteins). Accordingly, MEKA may play a role in signal transduction. MEKA is phosphorylated on Ser73 by cAMP-dependent protein kinase. In the present report, MEKA was studied using an antiserum (Anti-32) against ... 96, which can be used to estimate total MEKA and the phosphorylation state of MEKA. It was confirmed that MEKA is rapidly phosphorylated by adrenergic stimulation of pineal ...
Tópico(s): Neurobiology and Insect Physiology Research
1991 - Oxford University Press | Endocrinology
Tamar Babila, Nicolas Schaad, William F. Simonds, Toshimichi Shinohara, David C. Klein,
... bound to an acidic 33 kDa phosphoprotein termed MEKA or phosducin; MEKA is a substrate of cyclic AMP-dependent protein ... and S-antigen, in pineal and retinal tissue. MEKA was absent in the pineal gland prior to ... of Gβ in the cytoplasm precedes that of MEKA and does not appear to require the presence of MEKA. The absence of MEKA at this time indicates that the cyclic AMP ... serotonin N-acetyltransferase activity is not mediated by MEKA, which has been considered as a possible role of MEKA. After postnatal day 7, pineal MEKA and cytoplasmic ...
Tópico(s): Neuroscience and Neuropharmacology Research
1992 - Elsevier BV | Brain Research
The MEKA programme in Baden-Württemberg is one of Germany's most recent agri-environmental schemes. Prescriptions of the MEKA programme are briefly described and compared with other ... and a more detailed case study of the MEKA programme from the district of Heidenheim, eastern Baden- ... zone enforcing stringent environmental regulations. Consequently, landholders joining MEKA do not have to change farm management practices ... of regular payments provided through programmes such as MEKA. However, the voluntary nature of MEKA means that ...
Tópico(s): Agricultural Innovations and Practices
1995 - Elsevier BV | Journal of Rural Studies
Yacob Gómez-Llorente, Ryan J. Fletcher, Xiaojiang S. Chen, J.M. Carazo, Carmen San Martı́n,
... of single heptamers or single hexamers (Pape, T., Meka, H., Chen, S., Vicentini, G., Van Heel, M., ... of single heptamers or single hexamers (Pape, T., Meka, H., Chen, S., Vicentini, G., Van Heel, M., ... 797Crossref PubMed Scopus (83) Google Scholar, 11Pape T. Meka H. Chen S. Vicentini G. Heel Van M. ... in the hexameric ring of mtMCM (11Pape T. Meka H. Chen S. Vicentini G. Heel Van M. ... 797Crossref PubMed Scopus (83) Google Scholar, 11Pape T. Meka H. Chen S. Vicentini G. Heel Van M. ... N-terminal and C-terminal tiers (11Pape T. Meka H. Chen S. Vicentini G. Heel Van M. ...
Tópico(s): Porphyrin Metabolism and Disorders
2005 - Elsevier BV | Journal of Biological Chemistry
Che‐Hui Kuo, Mariko Akiyama, Naomasa Miki,
... 5.35, respectively. We designated it as a MEKA protein, because its amino acid sequence starts from ... It was found by in situ hybridization that MEKA mRNA was transcribed only in the photoreceptor cells ... the inner segments just like opsin mRNA. The MEKA cDNA was ligated with expression vector PEX 1, and a MEKA-fusion protein synthesized in E. coli was purified ... an antigen. By the Western blot analysis anti-MEKA protein serum reacted with a soluble 32 kDa ... from other tissues. Immunohistochemical study showed that anti-MEKA stained only the photoreceptor cells in bovine, chick, ...
Tópico(s): Cellular transport and secretion
1989 - Elsevier BV | Molecular Brain Research
Hidekazu Tanaka, Che‐Hui Kuo, Takahiko Matsuda, Yoshitaka Fukada, Fumio Hayashi, Yun Ding, Yasuyuki Irie, Naomasa Miki,
... of Tβγ with the photoreceptor disc membrane, and MEKA/phosducin is known to inhibit the association. In this study, we examined the effect of MEKA on the hydrophobicity of Tβγ.MEKA could bind to Tβγ without farnesyl/carboxyl-methyl ... the Triton X-114 phase separation assay, Tβγ-MEKA complex was recovered in the aqueous phase, whereas ... in the detergent phase. N-terminal portion of MEKA which includes Tβγ-binding domain was not sufficient ... Tβγ from the membrane. The data suggest that MEKA attenuates the hydrophobicity of Tβγ to result in ...
Tópico(s): Glycosylation and Glycoproteins Research
1996 - Elsevier BV | Biochemical and Biophysical Research Communications
Produção Nacional
Revisado por pares
Alex G. C. de Sá, Alex A. Freitas, Gisele L. Pappa,
This paper proposes $$\text {Auto-MEKA}_{\text {GGP}}$$ , an Automated Machine Learning (Auto-ML) method for Multi-Label Classification (MLC) based on the MEKA tool, which offers a number of MLC algorithms. ... tailored (optimized) for the input dataset. $$\text {Auto-MEKA}_{\text {GGP}}$$ addresses this problem with two key ... of choices of MLC algorithms and configurations from MEKA are represented into a grammar. Second, our proposed ... and configuration for the input dataset. $$\text {Auto-MEKA}_{\text {GGP}}$$ was tested in 10 datasets and ...
Tópico(s): Algorithms and Data Compression
2018 - Springer Science+Business Media | Lecture notes in computer science
Che‐Hui Kuo, Yoshifumi Watanabe, Kanato Yamagata, Naomasa Miki,
Antisera raised against photoreceptor-specific MEKA and opsin proteins were provided for immunohistochemical studies on the retinas of normal (BJ57BL/6) and retinal degeneration (rd, C3H/He) mice. The expression of MEKA protein began at postnatal day 6 (P6) in ... in both normal and rd mice. Thereafter the MEKA proteins in the photoreceptor cells of rd mice ... were increasing until P18. The time course of MEKA proteins in the photoreceptor cells of normal and ... to that of opsin protein, except that the MEKA protein disappeared earlier than opsin.
Tópico(s): Photochromic and Fluorescence Chemistry
1989 - Elsevier BV | Developmental Brain Research
Juan A. Reig, Lin Yu, David C. Klein,
... tissues is a previously reported 33-kDa protein (MEKA); this protein is a PKA substrate which has ... which contained the 33-kDa protein identified as MEKA. Thus, it appears possible that MEKA is present in pineal cytoplasm in a 70- ... is the case in retina. The finding of MEKA in the pineal makes it the latest addition ...
Tópico(s): Cellular transport and secretion
1990 - Elsevier BV | Journal of Biological Chemistry
Christina Onaca, M. Kieninger, Karl‐H. Engesser, Josef Altenbuchner,
... deduced amino acid sequence of the first gene, mekA, had high similarity to Baeyer-Villiger monooxygenases; the ... for the subunits of an ATPase. Inactivation of mekA and mekB by insertion of the mini-transposon ... ketone degradation was observed by heterologous expression of mekA and mekB in Pseudomonas putida. A fragment containing mekA and mekB on a plasmid was not sufficient ... carbon source. The Baeyer-Villiger monooxygenase activity of MekA was clearly demonstrated by incubating a mekB transposon ...
Tópico(s): Microbial bioremediation and biosurfactants
2007 - American Society for Microbiology | Journal of Bacteriology
Hidekazu Tanaka, Chie Iwami, Che‐Hui Kuo, Yun Ding, Eunju Do, Yasuyuki Irie, Naomasa Miki,
MEKA/phosducin, a 33 kDa phosphoprotein in the photoreceptor cell, associates with transducin βγ(Tβγ) with its ... terminal domain (N-terminal 105 amino acids of MEKA), and translocates Tβγ from the photoreceptor disc membrane ... Tβγ-binding domain to aa 17–105 of MEKA, and showed that the activity of MEKA to translocate Tβγ depends on the domain. A series of deletion mutant MEKA proteins were prepared to investigate the domain of MEKA which binds to and translocates Tβγ. Both binding ... of the N-terminal 16 amino acids of MEKA, but completely abolished by further deletion to 42Val. ...
Tópico(s): Receptor Mechanisms and Signaling
1997 - Elsevier BV | Neurochemistry International
Che‐Hui Kuo, Hideo Taniura, Yoshifumi Watanabe, Yoshitaka Fukada, Tohru Yoshizawa, Naomasa Miki,
A photoreceptor-specific MEKA protein was purified from bovine retinal soluble fraction. The purified sample was eluted as a single peak of 74 ... Superose column, which was dissolved into three components, MEKA protein (32 kDa), beta-(36 kDa) and gamma-( ... From several lines of evidence, we concluded that MEKA protein is identical with a 33k phosphoprotein reported ...
Tópico(s): Cellular transport and secretion
1989 - Elsevier BV | Biochemical and Biophysical Research Communications
... were provided for immunohistochemistry with antiserum against a MEKA protein which is specific to photoreceptor cells. In dark-adapted retinal sections, the anti-MEKA serum heavily stained outer segments of photoreceptor cells ... sections. These results indicate that the translocation of MEKA protein in a photoreceptor cell is regulated by ...
Tópico(s): Photochromic and Fluorescence Chemistry
1989 - Elsevier BV | Neuroscience Letters
Miku Maruyama, Miki Kobayashi, Takeshi Uchida, Eisaku Shimizu, H. Higashio, Misa Ohno, Shota Uesugi, Ken‐ichi Kimura,
... of both the methanol extract of Kuji amber (MEKA) and its main biologically active constituent, kujigamberol (15, ... ol) having activity against the mutant yeast. Both MEKA and kujigamberol inhibited the degranulation of RBL-2H3 ... rhinitis model of guinea pigs, nasal administration of MEKA and kujigamberol inhibited nasal blockade in a dose- ... drug, mometasone furoate. The growth-restoring activity of MEKA and kujigamberol against the mutant yeast is involved ...
Tópico(s): Neurobiology and Insect Physiology Research
2018 - Elsevier BV | Fitoterapia
Louise Marie Ngo Bidjeck Bondjè, Antoinette Solange Ipan, R.K. Ngena Tetsa, Eugène Pascal Binam Mandeng, Lucien Dieudonné Bitom,
... two weathering profiles developed on tholeiitic gabbro of Meka'a and alkali gabbro of Abiete, in southern ... apatite, chlorite, ilmenite and magnetite. The profile at Meka'a is made up of a coarse saprolite, ... kaolinite, quartz and anatase. Halloysite is specific to Meka'a while gibbsite and hematite occur only at Abiete. In the weathered profile of Meka'a, organic matter contents decrease downwards while pH ... Ce anomaly observed in the saprolitic set of Meka'a profile and in the coarse saprolite and ...
Tópico(s): Clay minerals and soil interactions
2018 - Elsevier BV | Journal of African Earth Sciences
Che‐Hui Kuo, Eiichi Taira, Natsuki Takaha, Hitoshi Sohma, T Akino, Yoshitaka Fukada, Kamon Sanada, N Miki,
Retinal 32 kDa MEKA protein (rMEKA) exists in the photoreceptor cells and forms a complex with β γ subunit of transducin. Bovine liver contained three MEKA-like proteins (94 kDa, 35 kDa-a, 35 ...
Tópico(s): RNA regulation and disease
1993 - Elsevier BV | Biochemical and Biophysical Research Communications
F. V. N. Rangarajan, A. C. Fabian, W. Forman, C. Jones,
... 0.9±0.1 keV using Mewe-Kaastra (MEKA) models. Within 10 kpc the temperature falls to 0.85 keV (RS) or 0.6 keV (MEKA). The surface brightness is well fitted by a ... to 46 kpc is over 1010 M⊙. The MEKA models show clear evidence of an absorbing column ...
Tópico(s): Phase Equilibria and Thermodynamics
1995 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Jesse Read, Peter Reutemann, Bernhard Pfahringer, Geoffrey Holmes,
... methods for this type of learning. We present MEKA: an open-source Java framework based on the well-known WEKA library. MEKA provides interfaces to facilitate practical application, and a ...
Tópico(s): Spam and Phishing Detection
2016 - The MIT Press | Journal of Machine Learning Research
Avi Levy, Harishchandra Ramadas, Thomas Rothvoß,
... brought polynomial time algorithms by Bansal, Lovett and Meka, and Rothvoss. All those algorithms are randomized, even ... polynomial time algorithm that is inspired by Lovett-Meka as well as the Multiplicative Weight Update method. ... assigned to the set constraints. A conjecture by Meka suggests that Spencer's bound can be generalized ...
Tópico(s): Markov Chains and Monte Carlo Methods
2017 - Springer Science+Business Media | Lecture notes in computer science
Si Si, Cho‐Jui Hsieh, Inderjit S. Dhillon,
... new kernel approximation framework - Memory Efficient Kernel Approximation (MEKA), which considers both low-rank and clustering structure ... the covtype dataset with half a million samples, MEKA takes around 70 seconds and uses less than ... approximation. We also present extensive experiments on applying MEKA to speed up kernel ridge regression.
Tópico(s): Face and Expression Recognition
2017 - The MIT Press | Journal of Machine Learning Research
Sebastianus Menggo, Pius Pandor, Sabina Ndiung,
... metaphor constructions and pedagogic values in the tiba meka dance. Students’ character building through metaphor construction in ... phenomenological method. The findings show that the tiba meka dance is inseparable from the use of metaphors, ... building for students. The ideologies that underline tiba meka dance are morals, identity, and economy.
Tópico(s): Cultural and Artistic Studies
2021 - Bina Nusantara University | Lingua Cultura
R.H. Lee, C. Andrew Fowler, J.F. McGinnis, Richard N. Lolley, Cheryl M. Craft,
... any sequenced protein except that coded by a MEKA cDNA clone (Kuo, C-H., Akiyama, M., and ... clone for bovine retinal phosducin confirmed that the MEKA clone deviation resulted from an unidentified cDNA guanosine ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
1990 - Elsevier BV | Journal of Biological Chemistry
... author on: Oxford Academic Google Scholar C S Meka, C S Meka 1Women's Research Institute, Department of Obstetrics and ...
Tópico(s): Neonatal Respiratory Health Research
1993 - Oxford University Press | Endocrinology
Robert K. Yu, Erhard Bieberich, Tian Xia, Guichao Zeng,
... to a simplified kinetic analysis [multienzyme kinetic analysis (MEKA)] of ganglioside biosynthesis by matrix calculation, which shows ... Biol. 1977; 83: 267-281Google Scholar). However, only MEKA has been able to correlate quantitatively the ganglioside ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2004 - Elsevier BV | Journal of Lipid Research
... algorithms such as the multiple extended Kalman algorithm (MEKA) and the decoupled extended Kalman filter algorithm (DEKF), ... results for three benchmark problems in comparison to MEKA, and in comparison to DEKF for highly coupled ...
Tópico(s): Target Tracking and Data Fusion in Sensor Networks
2000 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Neural Networks
Christian Troost, Teresa Walter, Thomas Berger,
... one hand, and the agri-environmental policy scheme MEKA, on the other. Our simulations indicate a potentially large decrease of MEKA participation due to biogas production supported under EEG. ...
Tópico(s): Biofuel production and bioconversion
2015 - Elsevier BV | Land Use Policy
... also the receptor tyrosine kinase Ret to PD (Meka et al., 2015). Currently there are only symptomatic ... Ret knockout mouse line (Kramer et al., 2007; Meka et al., 2015). In toxin induced PD animal ... familiar forms of PD (Aron et al., 2010; Meka et al., 2015). Single DJ-1 and parkin ... innervation in the striatum (Aron et al., 2010; Meka et al., 2015). DJ-1 and Ret signaling ... to stimulate mitochondrial integrity (Aron et al., 2010; Meka et al., 2015) (Figure 1). In addition, we ... degeneration of DA neurons in Ret-deficient mice (Meka et al., 2015). Our results suggest that parkin ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2015 - Medknow | Neural Regeneration Research
Daniela Russi, Hélène Margue, Rainer Oppermann, Clunie Keenleyside,
... with a set of rules. We have analysed MEKA-B4, the result-based agrienvironment measure in place ... farmers and key institutional actors. We argue that MEKA-B4 could be considered a Payment for Ecosystem ...
Tópico(s): Agricultural Economics and Policy
2016 - Elsevier BV | Land Use Policy
... n})$. Recent exciting work of Bansal, Lovett, and Meka shows that such colorings can be found in polynomial time. In fact, the Lovett--Meka algorithm finds a half integral point in any " ...
Tópico(s): Point processes and geometric inequalities
2017 - Society for Industrial and Applied Mathematics | SIAM Journal on Computing
Parikshit Gopalan, Daniel M. Kane, Raghu Meka,
... increasing independence paradigm of [D. M. Kane, R. Meka, and J. Nelson, Approximation, Randomization, and Combinatorial Optimization, ...
Tópico(s): Machine Learning and Algorithms
2018 - Society for Industrial and Applied Mathematics | SIAM Journal on Computing