Moyamoya disease (MMD), also known as spontaneous occlusion of the circle of Willis, is defined by progressive stenosis or occlusion of ... and Takaku, Arch Neurol 20:288-299, 1969). MMD is most common in East Asian countries such ... Korea, and it shows a slight female predominance. MMD is mainly characterized by ischemia and hemorrhage. Hemorrhagic MMD is very rare in children, and most cases ... popularization of imaging techniques. However, the pathogenesis of MMD is still not completely understood, and there is ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2023 - BioMed Central | Chinese Neurosurgical Journal
Miscellaneous Free eBooks
Irfahan Kassam, Li‐Lian Foo, Carla Lança, Lingqian Xu, Quan V. Hoang, Ching‐Yu Cheng, Pirro G. Hysi, Seang‐Mei Saw,
... predict high myopia (HM) and myopic macular degeneration (MMD) in an Asian population. Design Population-based study. ... refraction measurements, 240 individuals had a diagnosis of MMD graded by the International Photographic Classification and Grading ... its ability to predict patients with HM and MMD versus control participants. Main Outcome Measures The primary ... operating characteristic curve (AUC) to predict HM and MMD. Results The PRS had an AUC of 0. ... 66 (95% CI, 0.63–0.70) for MMD versus no myopia. The inclusion of the PRS ...
Tópico(s): Retinal Imaging and Analysis
2022 - Elsevier BV | Ophthalmology
Roberto De Icco, Gloria Vaghi, Marta Allena, Natascia Ghiotto, Elena Guaschino, Daniele Martinelli, Lara Ahmad, Michele Corrado, Federico Bighiani, Federica Tanganelli, Sara Bottiroli, Francescantonio Cammarota, Grazia Sances, Cristina Tassorelli,
... We collected the following variables: monthly migraine days (MMDs), monthly headache days (MHDs), days of acute medication ... erenumab was evaluated as: i) average reduction in MMDs during the 1-year treatment period; and ii) percentage of patients with ≥ 50% reduction in MMDs during the last 4 weeks after the 13 ... T13 ). Results Erenumab induced a sustained reduction in MMDs, MHDs and intake of acute medications across the ... 4% of patients reported a ≥ 50% reduction in MMDs (MMD Res ). MIDAS Res and MMD Res patients ...
Tópico(s): Trigeminal Neuralgia and Treatments
2022 - Springer Nature | The Journal of Headache and Pain
Li Lian Foo, Lingqian Xu, Charumathi Sabanayagam, Hla Myint Htoon, Marcus Ang, Jingwen Zhang, Kyoko Ohno‐Matsui, Ching‐Yu Cheng, Quan V. Hoang, Chuen-Seng Tan, Seang‐Mei Saw, Chee Wai Wong,
... investigate the predictive factors for myopic macular degeneration (MMD) and progression in adults with myopia. Methods We ... refraction and axial length (AL) measurements, were performed. MMD was graded from fundus photographs following the Meta- ... for Pathologic Myopia classification. The predictive factors for MMD development and progression were assessed in adults without and with MMD at baseline, respectively as risk ratios (RR) using ... of the predictive models for the development of MMD, with performance quantified by the area under the ...
Tópico(s): Glaucoma and retinal disorders
2022 - BMJ | British Journal of Ophthalmology
Abstract Background Moyamoya disease (MMD) is a rare chronic progressive cerebrovascular disease. Recent studies have shown that autoimmune inflammation may also be an important pathology in MMD but the molecular mechanisms of inflammation in this ... and the immune infiltration in vessel tissue of MMD using bioinformatics analysis. Methods Raw gene expression profiles ( ... to analyze the proportion of immune cells between MMD and an MMD-negative control group. We screened for neutrophil-associated ... metabolic pathways. The immune infiltration profile demonstrated that MMD cerebrovascular tissues contained a higher proportion of neutrophils, ...
Tópico(s): Aortic Disease and Treatment Approaches
2022 - BioMed Central | Orphanet Journal of Rare Diseases
Directory of Open Access Books (DOAB)
Wenzhu Song, Hao Gong, Qili Wang, Lijuan Zhang, Lixia Qiu, Xueli Hu, Huimin Han, Yaheng Li, Rongshan Li, Yafeng Li,
Multimorbidity (MMD) is a medical condition that is linked with high prevalence and closely related to many adverse health ... MMHC) algorithm to explore the network relationship between MMD and its related factors. We also aimed to ... 32 years, there are 9,129 ones without MMD (46.2%) and 10,623 ones with MMD (53.8%). Logistic regression model suggests that physical ... nap, smoking, and alcohol consumption are associated with MMD (P < 0.05). BNs, by establishing a complicated ... and physical activity have a direct connection with MMD. It also shows that education levels are indirectly ...
Tópico(s): Health disparities and outcomes
2022 - Frontiers Media | Frontiers in Cardiovascular Medicine
Raffaele Ornello, Carlo Baraldi, Simona Guerzoni, Giorgio Lambru, Anna P. Andreou, Bianca Raffaelli, Astrid Gendolla, Piero Barbanti, Cinzia Aurilia, Gabriella Egeo, Sabina Cevoli, Valentina Favoni, Fabrizio Vernieri, Claudia Altamura, Antonio Russo, Marcello Silvestro, Elisabetta Dalla Valle, Andrea Mancioli, Angelo Ranieri, Gennaro Alfieri, Н. В. Латышева, E. G. Filatova, Jamie Talbot, Shuli Cheng, Dagny Holle, Armin Scheffler, Tomáš Nežádal, Dana Čtrnáctá, Jitka Šípková, Zuzana Matoušová, Alfonsina Casalena, Maurizio Maddestra, Stefano Viola, Giannapia Affaitati, Maria Adele Giamberardino, Francesca Pistoia, Uwe Reuter, Simona Sacco,
... percent or absolute decrease in monthly migraine days [MMDs] or headache days compared with baseline). However, not enough attention has been paid to residual MMDs and/or migraine-related disability in treated patients. ... subgroup analysis on patients with complete data on MMDs at baseline and at weeks 9-12 of ... 49%, 50-74%, and ≥75% responders according to MMD decrease from baseline to weeks 9-12 of ... For each response category, we reported the median MMDs and Headache Impact test-6 (HIT-6) scores ... 9-12. We categorized the number of residual MMDs at weeks 9-12 as follows: 0-3, ...
Tópico(s): Pituitary Gland Disorders and Treatments
2022 - Springer Nature | The Journal of Headache and Pain
ASTM International
Junlin Lu, Jingyi Wang, Zhidong Lin, Guangchao Shi, Rong Wang, Yahui Zhao, Yuanli Zhao, Jizong Zhao,
... MMP)-9 levels with phenotypes of moyamoya disease (MMD). Methods: This study included plasma samples from 84 MMD patients. The clinical variables of these patients were ... using the ELISA method. Patients with hemorrhagic-onset MMD were compared with those with ischemic-onset MMD. Results: Compared with pediatric patients, the expression of ... in adult patients. In adult subgroup analysis, hemorrhagic MMD patients exhibited significantly higher serum concentrations of MMP-9 compared with ischemic MMD patients. The ROC curve identified that a baseline ...
Tópico(s): Cerebrovascular and genetic disorders
2021 - Frontiers Media | Frontiers in Neurology
Lauren Bailey, George K. Siberry, Patricia Agaba, Meaghan O'Keefe Douglas, Jessica R. Clinkscales, Catherine Godfrey,
Abstract Introduction Increasing access to multi‐month dispensing (MMD) of antiretroviral therapy (ART) supports treatment continuity and ... worked with ministries of health to scale up MMD and expand eligibility to new groups of PLHIV, ... between March and June 2020 addressing changes to MMD guidance during the COVID‐19 response. MMD coverage, the proportion of all ART clients on MMD, was assessed in the calendar quarters preceding the ... proportion Z‐test to test for differences in MMD coverage pre‐COVID‐19 (Q4 2019) and during ...
Tópico(s): COVID-19 Impact on Reproduction
2021 - International AIDS Society | Journal of the International AIDS Society
Shuo Yang, X. Wang, Weihua Liao, L. Li, Zhi‐Rong Tan, Liyuan Zhu, Ping Hu, Xiongjian Cui, Wu Xing,
•It is difficult to differentiate MMD from MMS. •Treatment of these disease is quite different. •This study aimed to distinguish MMD from AS-MMS from a clinical and imaging ... the vessel wall (VWI) for differentiating moyamoya disease (MMD) from atherosclerotic moyamoya syndrome (AS-MMS). MATERIALS AND METHODS Twenty-one patients with MMD or AS-MMS were assessed retrospectively by two ... of the two imaging methods for diagnosis of MMD. Interrater agreement was analysed using an unweighted Cohen's κ or interclass correlation coefficient (ICC). RESULTS MMD manifested as more concentric thickening, more homogeneous enhancement, ...
Tópico(s): Neurological Complications and Syndromes
2021 - Elsevier BV | Clinical Radiology
National Bureau of Economic Research (NBER)
Adam J. Kundishora, Samuel T. Peters, Amélie Pinard, Daniel Durán, Shreyas Panchagnula, Tanyeri Barak, Danielle F. Miyagishima, Weilai Dong, Hannah Smith, Jack Ocken, Ashley Dunbar, Carol Nelson‐Williams, Shozeb Haider, Rebecca L. Walker, Boyang Li, Hongyu Zhao, Dean Thumkeo, Arnaud Marlier, Phan Q. Duy, Nicholas S. Diab, Benjamin C. Reeves, Stephanie M. Robert, Nanthiya Sujijantarat, Amber N. Stratman, Yi-Hsien Chen, Shujuan Zhao, Isabelle Roszko, Qiongshi Lu, Bo Zhang, Shrikant Mane, Christopher Castaldi, Francesc López‐Giráldez, James Knight, Michael J. Bamshad, Deborah A. Nickerson, Daniel H. Geschwind, Shih-Shan Lang Chen, Phillip B. Storm, Michael L. DiLuna, Charles Matouk, Darren B. Orbach, Seth L. Alper, Edward R. Smith, Richard P. Lifton, Murat Günel, Dianna M. Milewicz, Sheng Chih Jin, Kristopher T. Kahle,
Importance Moyamoya disease (MMD), a progressive vasculopathy leading to narrowing and ultimate occlusion of the intracranial internal carotid arteries, is a cause of childhood stroke. The cause of MMD is poorly understood, but genetic factors play a role. Several familial forms of MMD have been identified, but the cause of most ... variants with large effect sizes are associated with MMD risk. Design, Setting, and Participants A genetic association ... was conducted using whole-exome sequencing case-parent MMD trios in a small discovery cohort collected over ...
Tópico(s): Cerebrovascular and genetic disorders
2021 - American Medical Association | JAMA Neurology
Project Gutenberg
Katarzyna Machaczek, Peter Allmark, Nicholas Pollard, Elizabeth Goyder, Mark Shea, Michelle Horspool, Suzanne Lee, Stephanie de‐la‐Haye, Robert Copeland, Scott Weich,
... an effective treatment for mild-to-moderate depression (MMD). However, a high proportion of patients with MMD are currently inactive and the implementation of PA as an adherent treatment for MMD is not well understood. This study contributes to ... exploring how to support people who are experiencing MMD to increase their PA levels (i.e. initiation and maintenance). It investigated which factors individuals with MMD perceived to be important for integrating PA into ... depth interviews were carried out with individuals with MMD (N = 6), and data were analysed using thematic ...
Tópico(s): Eating Disorders and Behaviors
2021 - Wiley | Health & Social Care in the Community
Chu-Qi Li, Qian‐Min Ge, Hui‐Ye Shu, Xu‐Lin Liao, Yi‐Cong Pan, Jieli Wu, Ting Su, Li-Juan Zhang, Rong‐Bin Liang, Yi Shao, Erming Zeng,
Background: Moyamoya disease (MMD) is a chronic progressive cerebrovascular abnormality characterized by chronic occlusion of large intracranial vessels with smoky vascular development at the base of the skull. In patients with MMD, abnormal spontaneous brain activity would be expected. Purpose: ... assess the brain activity changes in patients with MMD by resting-state functional MRI (rs-fMRI), using ... and Methods: A total of 17 patients with MMD (3 males and 14 females) and 17 healthy ... rs-fMRI to scan all the patients with MMD. Spontaneous neural activity was evaluated using the PerAF ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2021 - Frontiers Media | Frontiers in Neurology
Haogeng Sun, Wanjiang Li, Chao Xia, Yutao Ren, Lu Ma, Anqi Xiao, Chao You, Yi Liu, Rui Tian,
... stroke in the asymptomatic hemispheres of moyamoya disease (MMD), but it does not draw enough attention. The ... between the three types of asymptomatic hemispheres in MMD and their associations with the two types of ... symptomatic hemispheres in consecutive cases of single-center MMD patients, with an emphasis on imaging characterization regarding vascular morphology and cerebral perfusion. MMD hemispheres were categorized into 5 types: hemorrhagic hemispheres, ischemic hemispheres, asymptomatic hemispheres in unilateral hemorrhagic MMD, asymptomatic hemispheres in unilateral ischemic MMD, and bilateral ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2021 - Lippincott Williams & Wilkins | Stroke
Carla Lança, Chen Hsin Sun, Rachel S. Chong, Yee Ling Wong, Monisha E. Nongpiur, Hla Myint Htoon, Sahil Thakur, Debra Q Y Quek, Ching‐Yu Cheng, Quan V. Hoang, Charumathi Sabanayagam, Seang‐Mei Saw, Kah Hie Wong,
... visual field (VF) defects and myopic macular degeneration (MMD) in highly myopic adults without glaucoma. Methods Participants ( ... and pattern (eg, generalised sensitivity loss) were analysed. MMD presence was diagnosed from fundus photographs. Generalised estimating ... PSD, VF defects, CDR and IOP) associated with MMD. Results Mean age was 55.4±9.9 ... were women (AL=26.7±1.1 mm). MMD eyes had lower MD (−3.8±2.9 ... 7±0.6 dB). A higher percentage of MMD eyes (n=48) had abnormal VF (62.5% ... 28.6%; p<0.001) compared with no MMD (n=133 eyes). VF pattern in MMD eyes ...
Tópico(s): Retinal Imaging and Analysis
2021 - BMJ | British Journal of Ophthalmology