Directory of Open Access Journals (DOAJ)
Yoshikatsu Eto, T. Tokoro, Teruo Handa, N. Herschkowitz, Owen M. Rennert,
... and two European patients with multiple sulfatase deficiency (MSD). The Japanese patient with MSD contained excessive quantities of heparan sulfate and moderately ... sulfate A/C. Urinary excretion of AMPS in MSD heterozygotes was increased 2-fold compared to our ... pattern of AMPS in the mother of the MSD patient showed an increase of 18% heparan sulfate ... 10%). Seventy-five % of the AMPS and the MSD liver was heparan sulfate rather than dermatan sulfate. The degree of accumulation of AMPS in the MSD liver was 30–50 times that of the ...
Tópico(s): Carbohydrate Chemistry and Synthesis
1982 - Springer Nature | Pediatric Research
Derek Smith, Peter A. Leggat, Laurence J. Walsh,
Musculoskeletal disorders (MSD), needlestick and sharps injuries (NSI) and occupational skin diseases represent three of the most common workplace health issues in the dental profession.1 MSD are particularly important for dental students as research suggests that chronic MSD tends to appear early in dental careers.2 ... from a large dental school in Queensland, Australia. MSD were assessed via a modified version of the ... students.10 The self-reported prevalence rate of MSD at various body sites is displayed in Table ...
Tópico(s): Dental Anxiety and Anesthesia Techniques
2009 - Wiley | Australian Dental Journal
Helen Harcombe, David McBride, Sarah Derrett, Andrew Gray,
... the prevalence, characteristics and impact of musculoskeletal disorders (MSDs) in New Zealand nurses, postal workers and office workers.A postal survey asked participants about MSDs, (low back, neck, shoulder, elbow, wrist/hand or ... survey 88% of respondents had at least one MSD lasting longer than a day and 72% reported an MSD present for at least seven days. Of the 1,003 MSDs reported, 18% required time off work and 24% ... the month prior to the survey 17% of MSDs made functional tasks difficult or impossible. Low back, ...
Tópico(s): Ergonomics and Musculoskeletal Disorders
2009 - Elsevier BV | Australian and New Zealand Journal of Public Health
Jacques Simard, Yvan de Launoit, Fernand Labrie,
... the formation of a putative membrane-spanning domain (MSD) predicted between amino acid residues 75 and 91, chimeric cDNAs containing either type I MSD in type II (II + MSD) or an absence of this MSD in type I (I-MSD) were constructed and transiently expressed. The addition of MSD intype II 3 beta-HSD markedly increased the ... 40 microM for PREG and DHEA, respectively. II + MSD chimera thus encodes a protein having a relative ... type I 3 beta-HSD. Moreover, removal of MSD in the type I protein (I-MSD chimera) ...
Tópico(s): Steroid Chemistry and Biochemistry
1991 - Elsevier BV | Journal of Biological Chemistry
Yueming Qian, Caroline E. Grant, Christopher J. Westlake, Dawei Zhang, Peter A. Lander, Robert L. Shepard, Anne H. Dantzig, Susan P.C. Cole, Roger G. Deeley,
... region of MRP1's third membrane spanning domain (MSD). It is presently not known where GSH interacts ... linker (CL3) region connecting the first and second MSDs of the protein, but not the first MSD itself. Although required for binding, CL3 is not ... identify non-conserved amino acids in the third MSD that contribute to the high affinity with which ... region of MRP1's third membrane spanning domain (MSD). It is presently not known where GSH interacts ... linker (CL3) region connecting the first and second MSDs of the protein, but not the first MSD ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2002 - Elsevier BV | Journal of Biological Chemistry
Fredric Gerr, Michele Marcus, Cindy Ensor, David G. Kleinbaum, Susan Cohen, Alicia Edwards, Eileen M. Gentry, Daniel J. Ortiz, Carolyn Monteilh,
... arm (H/A) musculoskeletal symptoms (MSS) and disorders (MSD). Methods Individuals (n = 632) newly hired into jobs ... MSS. Those reporting MSS were examined for specific MSD. Incidence rates of MSS and MSD were estimated with survival analysis. Cox regression models ... between participant characteristics at entry and MSS and MSD. Results The annual incidence of N/S MSS ... cases/100 person‐years and of N/S MSD was 35 cases/100 person‐years. The most common N/S MSD was somatic pain syndrome. The annual incidence of ...
Tópico(s): Motor Control and Adaptation
2002 - Wiley | American Journal of Industrial Medicine
Daniel J. Weisdorf, Claudio Anasetti, Joseph H. Antin, Nancy A. Kernan, Craig Kollman, David S. Snyder, Effie W. Petersdorf, Gene Nelson, Philip B. McGlave,
... transplantations with 450 HLA-identical, matched sibling donor (MSD) transplantations performed at collaborating National Marrow Donor Program ... HLA-A, -B, and at -DRB1 alleles; all MSDs were genotypically identical at major histocompatibility loci. URD ... younger (median 36 vs 39, P = .001) than MSDs and underwent BMT later after diagnosis (median 17 [ ... relapse was low after either matched URD or MSD transplantations. We observed significantly though modestly poorer survival ... or only slightly inferior after matched URD versus MSD transplantation (age < 30: URD 61% ± 8% vs ...
Tópico(s): Eosinophilic Disorders and Syndromes
2002 - Elsevier BV | Blood
National Bureau of Economic Research (NBER)
Edgar Ong, Misa Suzuki, Frédéric Belot, Jiunn‐Chern Yeh, Isabelle Franceschini, Kiyohiko Angata, Ole Hindsgaul, Minoru Fukuda,
... alternative splicing of precursor mRNAs. Among them, NCAM(MSD) contains an additional domain, the so-called muscle-specific domain (MSD), consisting of 37 amino acids between two fibronectin ... PDF PubMed Scopus (168) Google Scholar). This NCAM(MSD) is mostly present in skeletal myotubes and often ... Text PDF PubMed Scopus (168) Google Scholar). The MSD is highly enriched with serine, threonine and proline ... Google Scholar). It has been shown that NCAM(MSD) from C2C12 myoblast cell line contains mucin-type ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2002 - Elsevier BV | Journal of Biological Chemistry
... 1.Structure and subcellular distribution of wt and msd PLP. (A) Cartoon depicting the topology of PLP. ... are shown by lines, the position of the msd mutation in TM4 is shown by an asterisk ... transfected with wt (left and center column) or msd (right column) PLPmh, fixed with 2% formaldehyde and ... of the protein. A well studied mutation, the msd allele, that causes complete ER retention of the ... membrane protein. The subcellular distribution of wt and msd PLP in COS-7 cells was examined by ... Simons et al., 2002). In contrast, staining of msd PLPmh was restricted to a reticular pattern typical ...
Tópico(s): RNA regulation and disease
2003 - Springer Nature | The EMBO Journal
Michelle Dawson, Denis Wirtz, Justin Hanes,
... into families of time-averaged mean squared displacements (MSD), 〈Δr2(τ)〉 = 〈[x(t + τ) – x(t)]2 + [ ... scale or time lag), from which distributions of MSDs, time-dependent particle diffusion coefficients, and apparent local ... captured and transformed into families of time-averaged MSDs, 〈Δr2(τ)〉 = 〈[x(Δt + τ) – x(Δt)]2 + [ ... lag; t = elapsed time), from which distributions of MSDs, time-dependent particle diffusion coefficients, and apparent local ... 3282-3285Crossref Scopus (687) Google Scholar). Individual particle MSDs were used to determine averaged (or “ensemble-averaged”) ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2003 - Elsevier BV | Journal of Biological Chemistry
Chris Molenaar, Karien C. Wiesmeijer, N. P. Verwoerd, Shadi Khazen, Roland Eils, Hans J. Tanke, Roeland W. Dirks,
... mobility further, we plotted the mean square displacement (MSD) of telomere spots (after correction for cell mobility) over increasing time intervals (Δt). MSD/Δt plots of individual telomeres revealed a large ... the basis of the distribution of the telomere MSDs, three categories of telomere movements were found. The ... telomeres showed a slow, constrained diffusion, reaching an MSD plateau at around 0.2 μm2 (Figure 4A ... telomeres, showed constrained movements over larger distances, reaching MSD plateaus between 0.4 and 2 μm2, with ...
Tópico(s): Telomeres, Telomerase, and Senescence
2003 - Springer Nature | The EMBO Journal
... ms, n = 3078 molecules). The mean-square displacement (MSD) corresponding to trajectories of individual fluorescent molecules dried ... entered a synaptic site. (B) Plots of the MSD versus time intervals τ for four trajectories shown ... analysis of AMPARs diffusion: plots of the mean MSD and derived from the analysis of the square ... in Figure 2A, and Supplementary movie 2). The MSD is widely used to extract diffusion characteristics from trajectories. In Figure 2B, the MSD is plotted as a function of time for ...
Tópico(s): Neural dynamics and brain function
2003 - Springer Nature | The EMBO Journal
Misa Suzuki, Kiyohiko Angata, Jun Nakayama, Minoru Fukuda,
... in muscle tissue contains a muscle-specific domain (MSD) to which mucin type O-glycans are attached. ... C2C12 myoblast system, we show that NCAM containing MSD is increasingly expressed on the cell surface as ... forms of NCAM, we found that NCAM containing MSD facilitates myoblast fusion, and this effect is diminished by mutating O-glycosylation sites at MSD. By contrast, forced expression of polysialic acid in ... and delays the expression of NCAM containing the MSD domain. Strikingly, inhibition of polysialic acid synthesis by ...
Tópico(s): Signaling Pathways in Disease
2003 - Elsevier BV | Journal of Biological Chemistry
Jeffrey L. Jackson, Kurt Kroenke,
... the prevalence, impact, and prognosis of multisomatoform disorder (MSD) over a 5-year period in a primary ... 4th Edition (DSM-IV) criteria for somatization disorder. MSD, defined as > or = 3 bothersome, medically unexplained somatic ... difficulty. Utilization was obtained from our health database.MSD had an 8% prevalence at both baseline (n = ... 500) and at 5 years (n = 33/387). MSD persisted in 21% of those with MSD at baseline, and developed in 7% of those without MSD at baseline. MSD at baseline was a predictor of MSD at ...
Tópico(s): Mental Health and Psychiatry
2008 - Lippincott Williams & Wilkins | Psychosomatic Medicine
Timo Vesikari, Pierre Van Damme, Carlo Giaquinto, Jim Gray, Jacek Mrukowicz, Ron Dagan, Alfredo Guarino, Hania Szajewska, Vytautas Usonis,
... human–bovine reassortant RV vaccine (RotaTeq; Sanofi Pasteur MSD, Lyon, France). As of October 2007, Rotarix had ... vaccine studies for Merck, Sanofi Pasteur, Sanofi Pasteur MSD, GlaxoSmithKline Biologicals, Wyeth, and Berna Biotech, a Crucell ... travel support grants and honoraria from Sanofi Pasteur MSD, Merck, and GlaxoSmithKline Biologicals. C.G. has been ... investigator in epidemiological studies supported by Sanofi Pasteur MSD and GlaxoSmithKline Biologicals. He also has received honoraria ... Bristol-Myers Squibb, Gilead, GlaxoSmithKline Biologicals, Sanofi Pasteur MSD, and Tibotec. J.G. is principal investigator and ...
Tópico(s): Viral Infections and Immunology Research
2008 - Lippincott Williams & Wilkins | Journal of Pediatric Gastroenterology and Nutrition