Toshiki Takai, Yoshinori Nishita, Sanae M.M. Iguchi‐Ariga, Hiroyoshi Ariga,
We have previously reported the human cDNA encoding MSSP-1, a sequence-specific double- and single-stranded ... Arlga and Arlga (1994) Oncogene, 9, 1133-1143]. MSSP-1 binds to a DNA replication orlgln/transcrlptlonal ... 2687 - 2693]. We have cloned the cDNA for MSSP-2, another member of the MSSP family of proteins. The MSSP-2 cDNA shares highly homologous sequences with MSSP-1 cDNA, except for the Insertion of 48 ... 16 amino acids near the C-termlnus. Like MSSP-1, MSSP-2 has RNP-1 consensus sequences. The results ...
Tópico(s): RNA Research and Splicing
1994 - Oxford University Press | Nucleic Acids Research
Jun Nomura, Kenichi Matsumoto, Sanae M.M. Iguchi‐Ariga, Hiroyoshi Ariga,
MSSP has been identified as a transcription factor that regulates the c-myc gene. MSSP was later found to positively or negatively regulate ... the thyrotropin receptor. The knockout mice for the Mssp gene developed by us revealed that these mice ... E2.5. In this study, we further analyzed Mssp-knockout mice and found that the expression of ... of Fas-mediated induction of apoptosis both in Mssp-knockout mice and primary thymocytes. MSSP was then found to stimulate promoter activity of ... to −635 in chromatin immunoprecipitation assays. Binding of MSSP in the MSSP-binding sequence, TCTAAT, located in ...
Tópico(s): Ubiquitin and proteasome pathways
2005 - Elsevier BV | Experimental Cell Research
Christian Haigermoser, Mitsuaki Fujimoto, Sanae M.M. Iguchi‐Ariga, Hiroyoshi Ariga,
MSSP proteins have been identified by their binding to an upstream element of c-myc . Independently, two ... yielded two cDNA clones highly homologous to the MSSP cDNAs, suggesting an involvement of MSSP in the regulation of the cell cycle (scr2) ... to two different gene loci. Whereas the human MSSP gene 1 turned out to be intronless, the ... flanking direct repeats have been detected in the MSSP gene 1, showing that it possesses all the ... fragment of the 5′ flanking region of the MSSP gene 2 revealed that the promoter of gene ...
Tópico(s): Genomics and Chromatin Dynamics
1996 - Oxford University Press | Nucleic Acids Research
Takeshi Niki, Sachiyo Izumi, Yumiko Saëgusa, Takahiro Taira, Toshiki Takai, Sanae M.M. Iguchi‐Ariga, Hiroyoshi Ariga,
Background MSSPs, m yc s ingle s trand binding p roteins, were originally identified as proteins recognizing a putative ... The cDNAs encoding four of the family proteins, MSSP‐1, MSSP‐2, Scr2 and Scr3, were cloned. These proteins ... to the S phase. Results We report that MSSP‐1 and MSSP‐2 bound directly to the C‐terminal portion ... c‐Myc, along with Max, side by side. MSSP, c‐Myc and Max formed a ternary complex in vivo , although MSSP did not directly associate with Max. The MSSP/Myc/Max ternary complex lost the binding activity ...
Tópico(s): Genomics and Chromatin Dynamics
2000 - Wiley | Genes to Cells
Mitsuaki Fujimoto, Kenichi Matsumoto, Sanae M.M. Iguchi‐Ariga, Hiroyoshi Ariga,
Background MSSP, c‐ myc single‐strand binding protein, works as a factor for DNA replication, transcription, apoptosis induction, and ... The cDNAs encoding four of the family proteins, MSSP‐1, MSSP‐2, Scr2 and Scr3, were cloned. These proteins ... suggested to be indispensable to the functions of MSSP. Results To elucidate its role in vivo , we generated Mssp knockout mice by homologous recombination in embryonic stem cells. Although intercrossing of Mssp +/– mice gave rise to mice homozygous to the mutant Mssp allele (Mssp −/– ) and the Mssp −/– mice, once born, ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2001 - Wiley | Genes to Cells
Minako IIDA, Takahiro Taira, Hiroyoshi Ariga, Sanae M.M. Iguchi‐Ariga,
MSSP (c-myc gene single strand binding proteins) were identified as protein factors binding to a putative ... gene, and two cDNAs encoding highly homologous proteins, MSSP-1 and MSSP-2, have been cloned. Scr2, independently cloned as ... pombe, has turned out to be identical to MSSP-1. MSSP-1/Scr2 and MSSP-2 similarly stimulated the initiation of SV40 DNA ... S phase. Here, we examined the functions of MSSP in apoptosis. MSSP expression plasmids were transfected to human HeLa cells ... the β-galactosidase-positive cells were counted. Both MSSP-1 and 2 induced apoptosis in a dose- ...
Tópico(s): CRISPR and Genetic Engineering
1997 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Yong Wu, Richard Y.K. Fung, Gengzhong Feng, Nengmin Wang,
... a contract-theory model to investigate how an MSSP’s (Managed Security Service Provider) operating characteristics of ... security externality and firms’ information nature affect the MSSP’s strategic decisions, including the contract structure and ... substitutable, plays a crucial role in influencing an MSSP’s decisions. First, the MSSP tends to provider a contract with a lower ... the security externality affects the decisions of the MSSP who serves complementary firms and that who serves substitutable firms. Third, the MSSP’s optimum refund (service fee) to complementary firms ...
Tópico(s): Cybercrime and Law Enforcement Studies
2017 - Elsevier BV | Computers & Industrial Engineering
Xiaohu Dai, Ying Xu, Bin Dong,
Micron-sized silica particles (MSSP), ranging from 3 μm to 50 μm, have been widely found in the sewage sludge. The inhibition of MSSP to biogas conversion of both excess sludge (ES) ... It is observed that with the effect of MSSP, the net cumulative methane production (NCMP) of ES ... 215%, respectively, which implies a crucial role for MSSP in anaerobic sludge digestion. Analysis of physicochemical properties of sludges before and after interaction with MSSP reveals that MSSP can bond with organic matter ...
Tópico(s): Phosphorus and nutrient management
2017 - Elsevier BV | Water Research
Horiana B. Grosu, Macarena R. Vial, Mike Hernández, Li Liang, Roberto F. Casal, Georgie A. Eapen, David E. Ost,
Malignancy-associated secondary spontaneous pneumothorax (MSSP) poses significant challenges due to limited survival. By assessing risk factors associated with a MSSP recurrence, there is potential to identify patients who ... performed a retrospective cohort study of patients with MSSP. The primary outcome was time to MSSP recurrence. We used a competing risk model to identify risk factors associated with MSSP recurrence.A total of 2,532 patients were diagnosed with pneumothorax, with 114 having MSSP but only 96 were evaluable for the time- ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2019 - AME Publishing Company | Journal of Thoracic Disease
Brystana G. Kaufman, Emily C. O’Brien, Sally C. Stearns, Roland Matsouaka, George M. Holmes, Morris Weinberger, Lee H. Schwamm, Eric E. Smith, Gregg C. Fonarow, Ying Xian, Donald H. Taylor,
... the hypothesis that the Medicare Shared Savings Program (MSSP) is associated with increased hospice enrollment and inpatient ... outcomes before and after hospital participation in the MSSP for patients discharged from MSSP hospitals (N = 273) vs non‐MSSP hospitals (N = 1490). SETTING Records from a national ... 2014 (N = 324 959). INTERVENTION Discharge from an MSSP hospital or beneficiary alignment with an MSSP Accountable Care Organization (ACO). MEASUREMENTS Hospice enrollment in ... the low mortality risk group, discharge from an MSSP vs non‐MSSP hospital was associated with a ...
Tópico(s): Chronic Disease Management Strategies
2019 - Wiley | Journal of the American Geriatrics Society
Brystana G. Kaufman, Emily C. O’Brien, Sally C. Stearns, Roland Matsouaka, George M. Holmes, Morris Weinberger, Paula H. Song, Lee H. Schwamm, Eric E. Smith, Gregg C. Fonarow, Ying Xian,
... by provider participation in Medicare Shared Savings Program (MSSP) Accountable Care Organizations (ACOs) through systematic changes to ... and transitional care. To evaluate the association of MSSP with patient outcomes in the year following hospitalization ... used to compare outcomes before and after hospital MSSP implementation for patients (1) discharged from hospitals that chose to participate versus not participate in MSSP or (2) assigned to an MSSP ACO versus not or both. Unique estimates for ... and 2014 ACOs were generated. For hospitals joining MSSP in 2013 or 2014, the probability of discharge ...
Tópico(s): Chronic Disease Management Strategies
2019 - Springer Science+Business Media | Journal of General Internal Medicine
Lawan Larsuprom, Nutchaphon Rungroj, Chalermpol Lekcharoensuk, Chantima Pruksakorn, Sumet Kongkiatpaiboon, Charles Chen, Udomlak Sukatta,
... can be classified as meticillin-susceptible S. pseudintermedius (MSSP) or meticillin-resistant S. pseudintermedius (MRSP). MRSP infections ... α-mangostin will have in vitro activity against MSSP and MRSP isolated from canine pyoderma.Twenty-three samples, MSSP (n = 12) and MRSP (n = 11), isolated from ... w. The mean MIC of α-mangostin towards MSSP was 0.53 ± 0.35 μg/mL, whereas ... difference between the mean MIC of MRSP and MSSP (P = 0.84). After a 30 min exposure ... effective in inhibiting S. pseudintermedius (both MRSP and MSSP). Clinical studies are needed to investigate this effectiveness ...
Tópico(s): Fungal Infections and Studies
2019 - Wiley | Veterinary Dermatology
Adam A. Markovitz, John M. Hollingsworth, John Z. Ayanian, Edward C. Norton, Phyllis Yan, Andrew M. Ryan,
... organizations (ACOs) in the Medicare Shared Savings Program (MSSP) are associated with modest savings. However, prior research ... exit ACOs.To evaluate the effect of the MSSP on spending and quality while accounting for clinicians' nonrandom exit.Similar to prior MSSP analyses, this study compared MSSP ACO participants versus control beneficiaries using adjusted longitudinal ... effects, the share of nearby clinicians in the MSSP was used as an instrumental variable. Hip fracture ... The authors also tested for compositional changes among MSSP participants.Fee-for-service Medicare, 2008 through 2014. ...
Tópico(s): Patient Satisfaction in Healthcare
2019 - American College of Physicians | Annals of Internal Medicine
Yeunkyung Kim, Laurent G. Glance, Robert G. Holloway, Yue Li,
Hospitals participating in the Medicare Shared Savings Program (MSSP) share with the Centers for Medicare and Medicaid ... of care. Our aim was to determine whether MSSP is associated with changes in readmissions and mortality ... Medicare patients hospitalized with ischemic stroke, and whether MSSP has a different impact on safety net hospitals ( ... in-difference analysis was used to determine whether MSSP was associated with changes in hospital readmission and ... as well as to examine the impact of MSSP on SNHs compared to non-SNHs.MSSP-participating ...
Tópico(s): Emergency and Acute Care Studies
2020 - Lippincott Williams & Wilkins | Neurology
Andrea Acevedo, Brian Mullin, Ana M. Progovac, Theodore L. Caputi, J. Michael McWilliams, Benjamin Lê Cook,
... the impact of the Medicare Shared Savings Program (MSSP) ACOs on mental health and substance use services ... 2016. Study design We compared Medicare beneficiaries in MSSP ACOs to non‐MSSP beneficiaries, stratifying analyses by Medicare eligibility (disability vs ... 65+). We estimated difference‐in‐difference models of MSSP ACOs on mental health and substance use visits ( ... health conditions. To examine the differential impact of MSSP on our outcomes by race/ethnicity, we used ... Data collection/extraction methods Not applicable. Principal findings MSSP ACOs were associated with small reductions in outpatient ...
Tópico(s): Health disparities and outcomes
2021 - Wiley | Health Services Research
Roland Staud, Euna Koo, Michael E. Robinson, Donald D. Price,
... heat-induced pain is well characterized, mechanical SSP (MSSP) has been less studied. MSSP may be relevant for chronic pain conditions like ... pain syndrome. Our study was designed to determine MSSP in 12 normal controls (NC) and 11 FM subjects. MSSP testing consisted of 5 s suprathreshold pressure-pain ... mechanical stimuli as well as pain aftersensations. Although MSSP increased monotonically in NC and FM subjects, pressure ... despite higher experimental pain ratings, the magnitude of MSSP was not statistically different between NC and FM ...
Tópico(s): Pain Mechanisms and Treatments
2007 - Lippincott Williams & Wilkins | Pain
Yeunkyung Kim, Caroline P. Thirukumaran, Yue Li,
... Care Organizations in the Medicare Shared Savings Program (MSSP) have financial incentives to reduce the cost and ... However, previous research about the impact of the MSSP on readmissions is limited and mixed. Objective: To examine the association between hospital participation in the MSSP during the 2012–2013 period and reductions in ... in readmission rates for hospitals participating in the MSSP with that of other hospitals. Subjects: Acute care hospitals that either participated in the MSSP or did not participate in any of Medicare ...
Tópico(s): Chronic Disease Management Strategies
2018 - Lippincott Williams & Wilkins | Medical Care
Yong Wu, Junlin Duan, Tao Dai, Dong Cheng,
... security operations to professional managed security service providers (MSSPs) as a result of the sophistication of strategic hackers. Thus, how an MSSP makes security decisions according to a strategic hacker’ ... model, this paper examines the interaction between an MSSP and a strategic hacker based on both parties’ ... all information assets are worth protecting for the MSSP. For both parties, their optimal efforts do not ... we distinguish two types of security externalities including MSSP-side externality and hacker-side externality, and we ...
Tópico(s): Spam and Phishing Detection
2020 - Institute for Operations Research and the Management Sciences | Decision Analysis
Panagiotis Katsoris, Manolis Mavroidis, Anastassios C. Mintzas,
... major and three minor male specific serum proteins (MSSPs) have been identified in the Mediterranean fruit fly Ceratitis capitata . All five MSSPs accumulate in the haemolymph during the first 3 ... total haemolymph proteins in the adult males. All MSSPs are dimeric proteins consisting of two subunits with ... weights between 13.5 and 14.5 kDa. MSSP-1, 3, 4 and 5 are homodimers while MSSP-2 is a heterodimer. The two major MSSPs (MSSP-1 and 5) have been isolated. Antisera against these two MSSPs cross-react partially with each other's antigens ...
Tópico(s): Entomopathogenic Microorganisms in Pest Control
1990 - Elsevier BV | Insect Biochemistry
Riggs J. Klika, MARK S. ALDERDICE, John Kvale, Jay T. Kearney,
... laboratory assessment. Changes in maximal steady-state power (MSSP), power at lactate threshold (PT(lact)), maximal power ( ... with a Power Tap Pro power meter. The MSSP was defined as the average power during an ... Individual training ranges were calculated from the pre-MSSP in accordance with Carmichael Training Systems. Laboratory assessments ... on 24 of the participants the same weeks MSSP was evaluated. After training, MSSP increased 9.2% (195.4 +/- 56.6 vs. ... 5 +/- 47.6 W; p < 0.05). The MSSP was approximately 7.5 % higher than PT(lact). ...
Tópico(s): Children's Physical and Motor Development
2007 - Lippincott Williams & Wilkins | The Journal of Strength and Conditioning Research
Takeshi Niki, Ivo Galli, Hiroyoshi Ariga, Sanae M.M. Iguchi‐Ariga,
MSSP has been identified as a protein that binds to both single‐ and double‐stranded sequences of ... origin sequence in the human c‐ myc gene. MSSP possesses versatile functions, including stimulation of DNA replication, ... induction, and cell transformation coordinated by c‐Myc. MSSP contains two RNP domains, RNP1‐A and RNP1‐ ... are necessary for all of the functions of MSSP. In this study, we found that MSSP binds to the N‐terminal region of a ... both in vitro and in human cells. Furthermore, MSSP was released from the putative DNA replication origin ...
Tópico(s): RNA Research and Splicing
2000 - Wiley | FEBS Letters
S. Thymlanou, Manolis Mavroidis, G. Kokolakis, Katia Komitopoulou, Antigone Zacharopoulou, Anastassios C. Mintzas,
Abstract Male‐specific serum proteins (MSSPs) are low molecular weight proteins which accumulate in high amounts in the haemolymph of adult males of the medfly Ceratitis capitata . By screening an expression library with anti‐MSSP antibodies, we have isolated and determined the nucleotide ... coding for one of the male‐specific polypeptides (MSSP‐α). The MSSP‐α mRNA encodes a polypeptide of 144 amino ... analysis indicated that there are multiple copies of MSSP genes in the medfly genome. Northern analysis showed ...
Tópico(s): Insect symbiosis and bacterial influences
1998 - Wiley | Insect Molecular Biology
J. Michael McWilliams, Mehdi Najafzadeh, William H. Shrank, Jennifer M. Polinski,
... ACO) performance in the Medicare Shared Savings Program (MSSP) focus on disease control and medication use among ... To date, the association between participation in the MSSP by provider organizations and medication use or adherence ... To assess the association between exposure to the MSSP and changes in the use of and adherence ... estimated separately for cohorts of ACOs entering the MSSP in 2012, 2013, and 2014. Data analysis was ... attribution to an ACO after entry into the MSSP.Any use (at least 1 prescription fill) and ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2017 - American Medical Association | JAMA Cardiology
J. Michael McWilliams, Lauren Gilstrap, David G. Stevenson, Michael E. Chernew, Haiden A. Huskamp, David C. Grabowski,
... as ACOs in the Medicare Shared Savings Program (MSSP) and the pathways by which they occurred.With ... were performed before vs after entry into the MSSP. Differential changes were estimated separately for cohorts of ACOs entering the MSSP in 2012, 2013, and 2014.Patient attribution to an ACO in the MSSP.Postacute spending, discharge to a facility, length of ... 2012 cohort of 114 ACOs, participation in the MSSP was associated with an overall reduction in postacute ... care specifically for ACO patients. Participation in the MSSP was associated with smaller significant reductions in SNF ...
Tópico(s): Emergency and Acute Care Studies
2017 - American Medical Association | JAMA Internal Medicine
Adam A. Markovitz, John M. Hollingsworth, John Z. Ayanian, Edward C. Norton, Nicholas M. Moloci, Phyllis Yan, Andrew M. Ryan,
The Medicare Shared Savings Program (MSSP) adjusts savings benchmarks by beneficiaries' baseline risk scores. To discourage increased coding intensity, the benchmark is not adjusted upward if beneficiaries' risk scores rise while in the MSSP. As a result, accountable care organizations (ACOs) have ... beneficiaries. We examined whether beneficiaries' exposure to the MSSP was associated with within-beneficiary changes in risk ... associated with entry to or exit from the MSSP. We found that the MSSP was not associated ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2019 - Project HOPE | Health Affairs
J. Michael McWilliams, Laura A. Hatfield, Bruce E. Landon, Michael E. Chernew,
... risk selection in the Medicare Shared Savings Program (MSSP). Specifically, turnover in accountable care organization (ACO) physicians ... and lack of risk selection in the original MSSP design suggest opportunities to build on early progress. ... payment policy. Context The Medicare Shared Savings Program (MSSP) establishes incentives for participating accountable care organizations (ACOs) ... of Medicare claims data. First, we estimated overall MSSP savings through 2015 using a difference‐in‐differences ... effects, baseline or prospective assignment, and area‐level MSSP exposure to hold patient populations constant. Third, we ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2020 - Wiley | Milbank Quarterly
J. M. Bryan, Linda A. Frank, Barton W. Rohrbach, Laura J. Burgette, Christine L. Cain, David A. Bemis,
... medications in dogs with meticillin‐susceptible S. pseudintermedius (MSSP) and MRSP pyoderma. Animals/Methods – Medical records were reviewed retrospectively, and 123 MSSP and 93 MRSP clinical cases between January 2008 and April 2010 were included. Results – In MSSP infections, cefalexin and cefpodoxime were the most commonly ... cases, respectively. Adverse effects were reported in seven MSSP and 31 MRSP cases. The most commonly reported ... effects were gastrointestinal, prompting antibiotic discontinuation in three MSSP and 20 MRSP cases. Chloramphenicol was associated with ...
Tópico(s): Infectious Diseases and Tuberculosis
2012 - Wiley | Veterinary Dermatology
George K. Christophides, Ioannis Livadaras, Charalambos Savakis, Katia Komitopoulou,
Abstract Genes encoding predominantly male-specific serum polypeptides (MSSPs) in the medfly Ceratitis capitata are members of ... To study the transcriptional regulation of the genes MSSP-α2 and MSSP-β2, overlapping fragments of their promoters, containing the ... transcriptional activity of the corresponding endogenous genes. The MSSP-α2 promoter drives gene expression specifically in the fat body of the adult males, whereas the MSSP-β2 promoter directs gene expression in the midgut ... flies of both sexes. Thus, the very same MSSP-α2 promoter fragment directs expression in the adult ...
Tópico(s): Insect symbiosis and bacterial influences
2000 - Oxford University Press | Genetics
Asunur Cezar, Huseyin Cavusoglu, Srinivasan Raghunathan,
... information security operations to managed security service providers (MSSPs). Cost reduction and quality (security) improvement are often ... will outsource security if and only if the MSSP offers a quality advantage over in‐house operations, ... have stronger incentive to outsource security if the MSSP offers a higher quality in terms of preventing ... than in‐house management, a quality advantage of MSSP over in‐house management is neither a prerequisite ... guarantee that a firm will. In addition to MSSP quality, the type of externality (positive or negative), ...
Tópico(s): Information and Cyber Security
2016 - Wiley | Production and Operations Management