Andrew Robson, Janice Turner, Peter Brookes, Christina Hardyment, Stephen Fry, John McNamara, Jon Ashworth, Megan Mason, Stella Shamoon, Richard Whitehead, Robert Cole, Anna Jamieson, Harvey Nichols, Benedict Cottrell Boyce, PH, Adam Sherwin Media Reporter, Ian Nathan, Dr Thomas Stuttaford and Suzi Godson, Frances Gibb Legal Editor, Alexandra Blair, Tim De Lisle, Peter Lansley, Malanie Goose Editor, Boris Johnson, Chris Tarrant, Robert Thicknesse, A. J. Baker, Colin Moule, Paul Hoggart, David Powell Athietics Correspondent, Anita James, Andrew Healey, John Mulvey, Dominic Walker, Bob Geldof, Clare Lazaro, Michael Evans Defence Editor, Matt Wolf, Rowan Pelling, Philip Howard, Richard Beard, Hannah Betts, Hilary Finch, Carol Midgley, Charlotte Wilding, Milton Wainwright, Christine Seib, Joanna Bale, Stewart Tondler Crime Correspondent, James Bone, P. Walton, Nic Hopkins, Rachel Campbell-Johnston, Michael Bracewell, Clive Davis, Alexandra Frean Social Affairs Correspondent, Richard Hobson One-Day Cricket Correspondent, Athene, Elizabeth Judge, Gabrielle Starkey, Carl Mortished, Ronald Harwood, Jane Taylor-Hayhurst, K. J. Barker, Wendy Ide, James Hider, John Bungey, Francesca Gavin, Kevin Eason, Geoff Brown, Chris Sullivan, Giles Coren, Andrew Norfolk, Selfridges, Alastair Campbell, Grainne Gilmore and Christine Seib, Antonia Senior, David Wooley, Ben Webster Transport Correspondent, Mark Griffiths, Nancy Durrant, Valerie Elliott Countryside Editor, David McVay, John Clarke, Philip Webster and Tom Baldwin, Vinny Lee, Steve Keenan, Sam Llewellyn, Peter Cobb, Dave Robinson, Ruth Gledhill, Trevor Baylis, Russell Kempson and Oliver Kay, James Doran Wall Street Correspondent, Debra Craine, Giles Whittell and Ruth Gledhill, Simon Gray, Lawrence Dallaglio and Oliver Sweeney, Grainne Gilmore, Daniel Finkelstein, Dr Jane Collins, Angela Jameson Industrial Correspondent, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Maggi Hambling, Jane Clarke, Peter Ackroyd, Jo Morris, Ian Hewdett, Simon Cowell, Nicholas Roe, Alyson Rudd Steers You through the Sporting Weekend, Brian Wilson, Caitlin Moran, Gerry Hanson, Ian Belcher, Sorrel Downer, Valerie Elliott Consumer Editor, Roland Watson, Tina Gaudoin, Leo Lewls, Denis J. Ross, Alan M. Calverd, Stefanie Marsh, Greg Hurst, Genevieve Fox, Tim Teeman, Ruth Gledhill and Glles Whittell, Arwa Haider, Kate Muir, Rick Gekoski, Robert Burrow, JJ, Peter Paphides, Nigel Williamson, Daniel McGrory, Ed Potton, Gary Duncan Economics Editor, Oliver Kay, Carola Long, Stephen Anderton, Gavin Bell, James Hopkins, Amber Cowan, Melanie Ricky, David Lister, Mark Atherton, Lisa Armstrong, John Westerby, Roger Justice, Lisa Grainger, Patrick Hosking Investment Editor, Stevie Chick, Sarah Vine, Mark Henderson Science Correspondent, Sam Coates, Chris Power, Nigel Willamson, James Collard boards, Simon de Bruxelles, Rob Wright, Brigitte Lacombe, Susan Greenfield, Magnus Grimond, Edward Young, John Westernby and David Hands, Sarah Turner, Stuart Miles, Benjamin Fry, Lisa Stansfield, Fabio Annecchiarico, Lorraine Candy, Henry Osmaston, Raymond Keene, Lucia Adams, Adam Sage, David POWELL-Evans, Suzi Godson, Matthew Pryor, Sean MacAulay, Richard Springate, Joe Jackson, Domald MacEltlivray, Tom Baidwin and Philip Webster, David Hockney, Xan Rice, Jeremy Page, Robery Thicknesse, John Hayward, Chris Campling, Isabel Fonseca, Patrick Hosking, Helen Nugent, Richard Owen, Shane Warne, Julie Myerson, Alex Hawkes, Mick Hume, M. Riley, Oliver August, Peter Dixon, Nick Hasell, Chloë Bryan-Brown, Jane MaCquitty, Mory Kante, Philiop Howard, David Hands Rugby Correspondent, James Collard, Julian Muscat, Elzabeth Judge, Chris Condron, Antony Worrall Thompson, Nigel Kendall, Maureen Shaw, Nell Harman Tennis Correspondent, PN, Jonathan Clayton, Philip Webster Political Editor, Robert Crampton, Sebastian Coe, Roderick Strange, Matthew Parris, Trevor Barnes, Virginia Blackburn, Mark Knopfler, Simon Callow, Jonathan Rendall, John Lister-Kaye, Russell Jenkins, M. Halsey, Ingrid Mansell, Rupert Montague Martin, Keith Blackmore, Iain Finlayson, Andrew Pierce and Shirley English, John Bentley, Sam McKnight, Charlotte Hatherley, DC, Alexandra Blair and Andrew Norfolk, Helen Pridham, Cath Urquhart Traveler Editor, Richard Beeston, Andrew Currie, Philippa Norman, David Charter Chief Political Correspondent, Alison Gibson, David Sanderson, Jacqui Goddard, John Naish, Anne Ashworth Personal Finance Editor, Annabelle Thorpe, Kieran Falconer, Cybill Shepherd, Catherine Philp, Martin Waller, Mark Henderson, Roberto Cavalli, N. Barry, John Lewis, Carl Mortished International Business Editor, Lis Stansfield, Sarah Butler, Benedict Nightingale, Peter Molloy, Colin Russell, Darian Leader, Angus Batey, Jonathan Meades, Seamus Murphy, Stephen Dalton, Jennifer Trehane, Tim Wapshott, Tom Roundell, Leo Lewis, Paul Connolly, Tom Chesshyre, James Christopher, Ben MacIntre, Simon Crompton, Ben Calder, Jeffrey Podolsky, A. E. C. Spencer, Francois Halard, Mark Harrison, Owen Slot, Tony Kelly, Kim Newman, Jenny Davey, S. Barnard, Garry Jenkins, Peter Klinger, Stephen Applebaum, Patience Wheatcroft, Joe Bolger, Christopher Irvine, James Goldman, Susan Emmett, Felix Dennis,
... Alexandre Aja, France, 85min Stars: Cècile de France, Maiwenn On general release, in French MVC DVD Review ...
2004 - Gale Group | TDA
... Varda to the twenty-first-century actor/director Maïwenn, have systematically turned their cameras towards their own ... self-presentation. In the second part (Sophie Calle, Maïwenn) storytelling makes its appearance, allowing the filmmakers a ...
Tópico(s): Historical Studies and Socio-cultural Analysis
2015 - Oxford University Press | French Studies
Noman Naeem, Klaus Stefan Drese, Lynn Paterson, Maïwenn Kersaudy-Kerhoas,
... U.K.More by Lynn PatersonView Biography, and Maïwenn Kersaudy-Kerhoas*Maïwenn Kersaudy-KerhoasInstitute of Biological Chemistry, Biophysics and Bioengineering, ... 9YL, U.K.*Email: [email protected]More by Maïwenn Kersaudy-KerhoasView Biographyhttps://orcid.org/0000-0002-8185- ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2021 - American Chemical Society | Analytical Chemistry
... in their films. Using Valeria Bruni Tedeschi and Maiwenn as case studies, this article considers how these ... pour un chameau… (Bruni Tedeschi, 2003), Pardonnez-moi (Maiwenn, 2006), Actrices (Bruni Tedeschi, 2007) and Le Bal des actrices (Maiwenn, 2009), they propose films labelled as fictions, which ...
Tópico(s): French Historical and Cultural Studies
2012 - Taylor & Francis | Studies in French Cinema
Leon-Samuel Icking, Andreas Martin Riedlberger, Fabian Krause, Jonas Widder, Anne Smedegaard Frederiksen, Fabian Stockert, Michael Spädt, Nikita Edel, Daniel Armbruster, Giada Forlani, Selene Franchini, Paulina Kaas, Büşra Merve Kırpat Konak, Fabrice Krier, Maïwenn Lefebvre, Daniel Mazraeh, Jeremy Ranniger, Johanna Gerstenecker, Pia Gescher, Karsten Voigt, Pavel Salavei, Nicole Gensch, Barbara Di Ventura, Mehmet Ali Öztürk,
Abstract The incorporation of non-canonical amino acids (ncAAs) into proteins is a powerful technique used in various research fields. Genetic code expansion (GCE) is the most common way to achieve this: a specific codon is selected to be decoded by a dedicated tRNA orthogonal to the endogenous ones. In the past 30 years, great progress has been made to obtain novel tRNA synthetases (aaRSs) accepting a variety of ncAAs with distinct physicochemical properties, to develop robust in vitro assays or approaches ...
Tópico(s): Genomics and Phylogenetic Studies
2023 - Oxford University Press | Nucleic Acids Research
Maïwenn Kerdreux, Sofia Edin, Thyra Löwenmark, Vicky Bronnec, Anna Löfgren‐Burström, Carl Zingmark, Ingrid Ljuslinder, Richard Palmqvist, Agnes Ling,
Microbiota dysbiosis may affect both the development and progression of colorectal cancer (CRC). Large metagenomic studies have highlighted specific oral bacteria linked to CRC including Porphyromonas gingivalis. Few studies have however analysed the implications of this bacterium in CRC progression and survival. In this study, we investigated the intestinal presence of P. gingivalis by qPCR in both faecal and mucosal samples from two different patient cohorts, including patients with precancerous ...
Tópico(s): Probiotics and Fermented Foods
2023 - Ivyspring International Publisher | Journal of Cancer
Appan Roychoudhury, James W. Dear, Maïwenn Kersaudy-Kerhoas, Till T. Bachmann,
Drug-induced liver injury (DILI) is a major challenge in clinical medicine and drug development. There is a need for rapid diagnostic tests, ideally at point-of-care. MicroRNA 122 (miR-122) is an early biomarker for DILI which is reported to increase in the blood before standard-of-care markers such as alanine aminotransferase activity. We developed an electrochemical biosensor for diagnosis of DILI by detecting miR-122 from clinical samples. We used electrochemical impedance spectroscopy (EIS) for ...
Tópico(s): RNA Interference and Gene Delivery
2023 - Elsevier BV | Biosensors and Bioelectronics
Francesco Lopresti, Bernardo Patella, Vito Divita, Claudio Zanca, Luigi Botta, Norbert Radacsi, Alan O’Riordan, Giuseppe Aiello, Maïwenn Kersaudy-Kerhoas, Rosalinda Inguanta, Vincenzo La Carrubba,
Wearable sensors for sweat biomarkers can provide facile analyte capability and monitoring for several diseases. In this work, a green wearable sensor for sweat absorption and chloride sensing is presented. In order to produce a sustainable device, polylactic acid (PLA) was used for both the substrate and the sweat absorption pad fabrication. The sensor material for chloride detection consisted of silver-based reference, working, and counter electrodes obtained from upcycled compact discs. The PLA ...
Tópico(s): Advanced Chemical Sensor Technologies
2022 - Multidisciplinary Digital Publishing Institute | Sensors
Anne‐Christine Uldry, Anabel Maciel‐Dominguez, Maïwenn Jornod, Natasha Buchs, Sophie Braga-Lagache, Justine Brodard, Jovana Janković, Nicolas Bonadies, Manfred Heller,
Circulating extracellular vesicles (cEV) are released by many kinds of cells and play an important role in cellular communication, signaling, inflammation modulation, coagulation, and tumor growth. cEV are of growing interest, not only as biomarkers, but also as potential treatment targets. However, very little is known about the effect of transporting biological samples from the clinical ward to the diagnostic laboratory, notably on the protein composition. Pneumatic tube systems (PTS) and human ...
Tópico(s): Blood properties and coagulation
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Alfredo E. Ongaro, Zibusiso Ndlovu, Elodie Sollier, Collins Otieno, Pascale Ondoa, Alice Street, Maïwenn Kersaudy-Kerhoas,
Single-use, disposable, point-of-care diagnostic devices carry great promise for global health, but present some challenges in terms of environmental sustainability. This perspective covers solutions to embed sustainability at the R&D and product development stages.
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2022 - Royal Society of Chemistry | Lab on a Chip
Raphaël Forquet, Maïwenn Pineau, William Nasser, Sylvie Reverchon, Sam Meyer,
In this study, we highlight the role of the discriminator as a global sensor of supercoiling variations and propose the first quantitative regulatory model of this principle, based on the specific step of promoter opening during transcription initiation. It defines the predictive rule by which SC quantitatively modulates the expression rate of bacterial promoters, depending on the G/C content of their discriminator and independently from promoter-specific regulatory proteins.
Tópico(s): Cancer Research and Treatments
2021 - American Society for Microbiology | mSystems
Hayriye Özçelik, Fareeha Batool, Maïwenn Corre, Alexandre Garlaschelli, Guillaume Conzatti, Céline Stutz, Catherine Petit, Eric Delpy, Franck Zal, Elisabeth Leize‐Zal, Olivier Huck,
Periodontitis is an inflammatory disease associated with anaerobic bacteria leading to the destruction of tooth-supporting tissues. Porphyromonas gingivalis is a keystone anaerobic pathogen involved in the development of severe lesions. Periodontal treatment aims to suppress subgingival biofilms and to restore tissue homeostasis . However, hypoxia impairs wound healing and promotes bacterial growth within periodontal pocket . This study aimed to evaluate the potential of local oxygen delivery through ...
Tópico(s): Obstructive Sleep Apnea Research
2021 - Elsevier BV | International Journal of Pharmaceutics
Augustin Coisne, David Montaigne, Samy Aghezzaf, Hélène Ridon, S. Mouton, Marjorie Richardson, Anne‐Sophie Polge, Patrizio Lancellotti, Christophe Bauters, Luc Abramovici, Jean-Charles Aisenfarb, Moulay Alaoui, Ahmed Amiar, Mariam Arabidze, Valérie Aumégeat, Laurence Avez-Lemaire, Hélène Bardet, Karine Bauley, J Becquart, Aida Ben Abda, Frédéric Biausque, Fanny Boudghene Stambouli, Bertrand Boutié, D. Broucqsault, Jean-Michel Bruffau, B Brullard, Laurent Carpentier, Sébastien Caudmont, Karim Chachoua, Akram Chmaït, Maïwenn Clement-Dupont, Christophe Cordier, Alessandro Cosenza, J Coulomb, Vladimir Cousin, Elise Dassonvalle, Guillaume de Geeter, Pascal de Groote, Eric Decoulx, M Delomez, Pascal Delsart, François Destombes, Nicolas Détis, Michel Devillers, Olivia Domanski, Audrey Duchemin, Xavier Dujardin, Anju Duva Pentiah, Nima Endjah, O Equine, Marie Fertin, Bruno Fournier, Dauphine Garin, Antonio Gongora, Lorraine Greffe, G. Hannebicque, Jérôme Haye, Eléonore Hebbar, Vincent Hennebelle, Olivier Hennebert, Gérard Houdain, Arnaud Hubert, C Hudelo, Thibault Hus, Olivier Jabourek, Mathilde Jacquelinet, T Jacquemart, Belaid Jellouli, Antoine Jeu, Messaoud Kouidri, Francis Kozlowski, Robert Lallemant, Nicolas Lamblin, Patricia Langlois, Guillaume Ledieu, Yann Lefetz, Philippe Lejeune, François Leleu, Nestor Lemaire, Rémy Lubret, Anne‐Laure Madika, Philippe Marboeuf, Thibaud Meurice, Jonathan Meurice, A Millaire, Frédéric Mouquet, Aurélie Musschoot, Christophe Mycinski, Dan Valentin Neicu, Olivier Nugue, Rahma Ouardani, Karima Ouchallal, François Passard, Max Pécheux, Karine Pedelhez, Alain Petit, André Philias, Rosario Pilato, P Pruvost, Arnaud Quercy, Marc Sagot, Karine Sautiere-Tricot, Christine Savoye, Benoit Segrestin, Kouroch Taghipour, Véronique Taverne, Dieudonné Tchatchoua, Sylvie Tondeux, Olivier Tricot, Arthur Vaksmann, Dominique Vandamme, Claire Vanesson, B Vaquette, Eric Verbrugge, Mathieu Verhaeghe, R Viart, Hubert Vodoungnon, Julien Voyez, S Werquin, Maud Wibaux,
Importance Modern data regarding incidence and modes of death of patients with aortic stenosis (AS) are restricted to tertiary centers or studies of aortic valve replacement (AVR). Objective To provide new insights into the natural history of outpatients with native AS based on a large regionwide population study with inclusion by all cardiologists regardless of their mode of practice. Design, Setting, and Participants Between May 2016 and December 2017, consecutive outpatients with mild (peak aortic velocity, ...
Tópico(s): Cardiac Structural Anomalies and Repair
2021 - American Medical Association | JAMA Cardiology
Xinlei Yao, Maxime Vonesch, Maïwenn Combes, Jean Weiss, Xiaonan Sun, Jean Lacroix,
Single-molecule junctions (SMJs) have been fabricated using layers generated by diazonium electroreduction. This process creates a C–Au covalent bond between the molecule and the electrode. Rigid oligomers of variable length, based on porphyrin derivatives in their free base or cobalt complex forms, have been grafted on the surface. The conductance of the oligomers has been studied by a scanning tunneling microscopy break junction (STM-bj) technique and G(t) measurements, and the lifetime of the SMJs ...
Tópico(s): Nanowire Synthesis and Applications
2021 - American Chemical Society | Nano Letters
Sayem Ahmed, Guibehi Benjamin Koudou, Maïwenn Bagot, François Drabo, Windtaré Roland Bougma, Caisey V. Pulford, Moses J. Bockarie, Robert A. Harrison,
Snakebite has become better recognized as a significant cause of death and disability in Sub-Saharan Africa, but the health economic consequences to victims and health infrastructures serving them remain poorly understood. This information gap is important as it provides an evidence-base guiding national and international health policy decision making on the most cost-effective interventions to better manage snakebite. Here, we assessed hospital-based data to estimate the health economic burden ...
Tópico(s): Rabies epidemiology and control
2021 - Public Library of Science | PLoS neglected tropical diseases
Fernando Albuquerque de Almeida, Maiwenn Al, Ron Koymans, Jarno Riistama, Steffen Pauws, Johan L. Severens,
Abstract Background Empirical identification of the direct impact of hospitalisation in the change in utility could provide an interpretation for some of the unexplained variance in quality of life responses in clinical practice and clinical trials and provide assistance to researchers in assessing the impact of a hospitalisation in the context of economic evaluations. This study had the goal of determining the impact of nonfatal hospitalisations on the quality of life of a cohort of patients previously ...
Tópico(s): Healthcare Policy and Management
2020 - BioMed Central | Health and Quality of Life Outcomes
Nigel Armstrong, Nasuh Büyükkaramikli, Hannah Penton, Rob Riemsma, Pim Wetzelaer, Vanesa Huertas Carrera, Stephanie L. Swift, Thea Marie Drachen, Heike Raatz, Steve Ryder, Dhwani Shah, Titas Buksnys, Gill Worthy, Steven Duffy, Maiwenn Al, Jos Kleijnen,
Background There have been no licensed treatment options in the UK for treating thrombocytopenia in people with chronic liver disease requiring surgery. Established management largely involves platelet transfusion prior to the procedure or as rescue therapy for bleeding due to the procedure. Objectives To assess the clinical effectiveness and cost-effectiveness of two thrombopoietin receptor agonists, avatrombopag (Doptelet ® ; Dova Pharmaceuticals, Durham, NC, USA) and lusutrombopag (Mulpleta ® ; Shionogi ...
Tópico(s): Gastrointestinal Bleeding Diagnosis and Treatment
2020 - NIHR Journals Library | Health Technology Assessment
Alvaro J. Conde, Ieva Keraite, Alfredo E. Ongaro, Maïwenn Kersaudy-Kerhoas,
A low-cost and easy to implement acoustic micromixer compatible with multiple fabrication technologies that can provide efficient and vigorous mixing.
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2020 - Royal Society of Chemistry | Lab on a Chip
Alfredo E. Ongaro, Davide Di Giuseppe, Ali Kermanizadeh, Allende Miguelez Crespo, Arianna Mencattini, Lina Ghibelli, Vanessa Mancini, Krystian L. Wlodarczyk, Duncan P. Hand, Eugenio Martinelli, Vicki Stone, Nicola M. Howarth, Vincenzo La Carrubba, Virginia Pensabene, Maïwenn Kersaudy-Kerhoas,
Organ-on-chip (OOC) devices are miniaturized devices replacing animal models in drug discovery and toxicology studies. The majority of OOC devices are made from polydimethylsiloxane (PDMS), an elastomer widely used in microfluidic prototyping, but posing a number of challenges to experimentalists, including leaching of uncured oligomers and uncontrolled absorption of small compounds. Here we assess the suitability of polylactic acid (PLA) as a replacement material to PDMS for microfluidic cell culture ...
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2020 - American Chemical Society | Analytical Chemistry
Lise Rivière, Maïwenn Bergez, Saskia Mönch, Bingqian Qu, Maximilian Rieß, Florian W. R. Vondran, Juliane Liese, Veit Hornung, Stephan Urban, Renate König,
Hepatitis B virus (HBV) chronic infection is a critical risk factor for hepatocellular carcinoma. The innate immune response to HBV infection is a matter of debate. In particular, viral escape mechanisms are poorly understood. Our study reveals that HBV RNAs are not immunostimulatory in immunocompetent myeloid cells. In contrast, HBV DNA from viral particles and DNA replication intermediates are immunostimulatory and sensed by cyclic GMP-AMP Synthase (cGAS) and Stimulator of Interferon Genes (STING). ...
Tópico(s): HIV Research and Treatment
2020 - Multidisciplinary Digital Publishing Institute | Viruses
Ieva Keraite, Virginia Álvarez-García, Isaac García-Murillas, Matthew Beaney, Nicholas C. Turner, Clare Bartos, Olga Oikonomidou, Maïwenn Kersaudy-Kerhoas, Nicholas R. Leslie,
Abstract PIK3CA is one of the two most frequently mutated genes in breast cancers, occurring in 30–40% of cases. Four frequent ‘hotspot’ PIK3CA mutations (E542K, E545K, H1047R and H1047L) account for 80–90% of all PIK3CA mutations in human malignancies and represent predictive biomarkers. Here we describe a PIK3CA mutation specific nuclease-based enrichment assay, which combined with a low-cost real-time qPCR detection method, enhances assay detection sensitivity from 5% for E542K and 10% for E545K ...
Tópico(s): BRCA gene mutations in cancer
2020 - Nature Portfolio | Scientific Reports
Aurélie Penaud, A. Ganne, Frédérique Eynaud, Clément Lambert, Pierre-Olivier Coste, Maïwenn Herlédan, Muriel Vidal, J. Goslin, Pierre Stéphan, Guillaume Charria, Yvan Pailler, M. Durand, Jéna Zumaque, Meryem Mojtahid,
We discuss paleoenvironments of north-western France over the last 7 kyrs in terms of: i) long-term changes (relative sea-level rise and boreal summer insolation), ii) rapid climate changes (millennial-scale Bond events and multi-decadal regimes of the North Atlantic Oscillation: NAO) and iii) growing human impacts in watersheds. Our study focuses on the CBT-CS11 core, retrieved in the northern Bay of Biscay, with new high-resolution (70 years) palynological data (dinoflagellate cysts and pollen), combined ...
Tópico(s): Maritime and Coastal Archaeology
2020 - Elsevier BV | Quaternary Science Reviews
Rick A. Vreman, Joost W. Geenen, Anke M. Hövels, Wim Goettsch, Hubert G. M. Leufkens, Maiwenn Al,
The objective of this study was to construct an early economic evaluation for acalabrutinib for relapsed chronic lymphocytic leukaemia (CLL) to assist early reimbursement decision making. Scenarios were assessed to find the relative impact of critical parameters on incremental costs and quality-adjusted life-years (QALYs). A partitioned survival model was constructed comparing acalabrutinib and ibrutinib from a UK national health service perspective. This model included states for progression-free ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2019 - Adis, Springer Healthcare | Applied Health Economics and Health Policy
Francesco Lopresti, Francesco Carfì Pavia, Ilenia Vitrano, Maïwenn Kersaudy-Kerhoas, Valerio Brucato, Vincenzo La Carrubba,
The growing demand for nanofibrous biocomposites able to provide peculiar properties requires systematic investigations of processing-structure-property relationships. Understanding the morpho-mechanical properties of an electrospun scaffold as a function of the filler features and mat microstructure can aid in designing these systems. In this work, the reinforcing effect of micrometric and nanometric hydroxyapatite particles in polylactic acid-based electrospun scaffold presenting random and aligned ...
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2019 - Elsevier BV | Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials
Marscha S. Holleman, Harm van Tinteren, Harry J.M. Groen, Maiwenn Al, Carin A. Uyl‐de Groot,
Background: EGFR-tyrosine kinase inhibitors (EGFR-TKIs) including afatinib, dacomitinib, erlotinib, gefitinib, and osimertinib have proven efficacy in terms of progression-free survival (PFS) in patients with non-small-cell lung cancer (NSCLC) harboring EGFR mutations. However, an overall view for comparing efficacy and toxicity on a meta-level is lacking. This study compared efficacy and toxicity of first-line treatment with five different EGFR-TKIs by conducting a network meta-analysis (NMA). Methods: ...
Tópico(s): Lung Cancer Research Studies
2019 - Dove Medical Press | OncoTargets and Therapy
Marscha S. Holleman, Maiwenn Al, Remziye Zaim, Harry J.M. Groen, Carin A. Uyl‐de Groot,
To compare the cost-effectiveness of first-line gefitinib, erlotinib, afatinib, and osimertinib in patients with non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations.
Tópico(s): Colorectal Cancer Treatments and Studies
2019 - Springer Science+Business Media | The European Journal of Health Economics
Nasuh Büyükkaramikli, Maureen Rutten‐van Mölken, Johan L. Severens, Maiwenn Al,
In health economic literature, checklists or best practice recommendations on model validation/credibility always declare verification of the programmed model as a fundamental step, such as 'is the model implemented correctly and does the implementation accurately represent the conceptual model?' However, to date, little operational guidance for the model verification process has been given. In this study, we aimed to create an operational checklist for model users or reviewers to verify the technical ...
Tópico(s): Healthcare Policy and Management
2019 - Adis, Springer Healthcare | PharmacoEconomics
Alfredo E. Ongaro, Ieva Keraite, Antonio Liga, Gioacchino Conoscenti, Stuart R. Coles, Holger Schulze, Till T. Bachmann, Khaled Parvez, Cinzia Casiraghi, Nicola M. Howarth, Vincenzo La Carrubba, Maïwenn Kersaudy-Kerhoas,
The employment of single-use, disposable medical equipment has increased the amount of medical waste produced and the advent of point-of-care diagnostics in lab-on-chip format is likely to add further volume. Current materials used for the manufacture of these devices are derived from petroleum sources and are, therefore, unsustainable. In addition, disposal of these plastics necessitates combustion to reduce infection risk, which has, depending on material composition, an undesirable environmental ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2018 - American Chemical Society | ACS Sustainable Chemistry & Engineering
Virginia Álvarez-García, Clare Bartos, Ieva Keraite, Urmi Trivedi, Paul M. Brennan, Maïwenn Kersaudy-Kerhoas, Karim Gharbi, Olga Oikonomidou, Nicholas R. Leslie,
PIK3CA mutations are seemingly the most common driver mutations in breast cancer with H1047R and E545K being the most common of these, accounting together for around 60% of all PIK3CA mutations and have promising therapeutic implications. Given the low sensitivity and the high cost of current genotyping methods we sought to develop fast, simple and inexpensive assays for PIK3CA H1047R and E545K mutation screening in clinical material. The methods we describe are based on a real-time PCR including ...
Tópico(s): Cancer Genomics and Diagnostics
2018 - Nature Portfolio | Scientific Reports
Ayokunle O. Olanrewaju, Maïwenn Beaugrand, Mohamed Yafia, David Juncker,
This review critically analyzes the history, fundamental operating principles, limitations, applications, and emerging ideas related to microchannel-based capillary microfluidics.
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2018 - Royal Society of Chemistry | Lab on a Chip