Produção Nacional
Revisado por pares
Miriam Santana, Ruan Carlos Macêdo de Moraes, Maria Martha Bernardi,
Cadmium (Cd) is an environmental pollutant that is able to alter the immune function. Previous studies have shown that, in mammals, chronic exposure to Cd decreases the release of macrophagic cytokines such as IL1 and TN alpha and decreases phagocytosis activity. On the other hand contradictory results showed an increase in the humoral response. The cellular response could be decreased by exposure to Cd. These alterations were observed in mammals. The present study aimed to investigate some of the ...
Tópico(s): Trace Elements in Health
2005 - Elsevier BV | Environmental Research
Produção Nacional
Revisado por pares
Fernanda Crunfli, Caio Henrique Mazucanti, Ruan Carlos Macêdo de Moraes, Andressa Pereira Costa, Alice Cristina Rodrigues, Cristóforo Scavone, Andréa da Silva Torrão,
Sporadic Alzheimer's disease (sAD) is associated with energy metabolism deficiency and impairment of insulin receptor (IR) signaling in the brain. In this context, low doses of intracerebroventricular (icv) injection of streptozotocin (STZ) in rodents has been used as an experimental model of sAD which leads to an insulin-resistant brain state and neurodegeneration. However, the STZ effects on brain insulin signaling-related proteins it is not appropriately elucidated. The aim of this study was to evaluate ...
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - IOS Press | Journal of Alzheimer s Disease
Produção Nacional
Revisado por pares
Ruan Carlos Macêdo de Moraes, Monique Patrício Singulani, Alisson Carvalho de Gonçalves, Guilherme Vannucchi Portari, Andréa da Silva Torrão,
It is well known that patients with Alzheimer's disease (AD) have imbalances in blood thiamine concentrations and lower activity of thiamine-dependent enzymes. Benfotiamine, a more bioavailable thiamine analog, has been proposed as an alternative to counteract these changes related to thiamine metabolism. Thus, our study aimed to analyze the effects of benfotiamine supplementation on brain thiamine absorption, as well as on parameters related to neuronal energy metabolism and disease progression ...
Tópico(s): Neurological and metabolic disorders
2020 - Elsevier BV | Experimental Gerontology
Produção Nacional
Revisado por pares
Victor Abou Nehmi, Gilson Masahiro Murata, Ruan Carlos Macêdo de Moraes, Gabriely Cristina Alves Lima, Danielle Araújo de Miranda, Katrin Radloff, Raquel Costa, Joyce de Cassia Rosa de Jesus, Jéssica Alves de Freitas, Nayara Izabel Viana, Ruan Pimenta, Kátia Ramos Moreira Leite, José Pinhata Otoch, Ana Flávia Marçal Pessoa,
To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics, yeast β-glucans, minerals and silymarin (Silybum marianum), on lipid and glycidic metabolism, inflammatory and mitochondrial proteins of the liver, in control and high-fat diet-induced obese mice.After an acclimation period, 32 male C57BL/6 mice were divided into the following groups: nonfat diet (NFD) vehicle, NFD supplemented, high-fat diet (HFD) vehicle and HFD supplemented. The vehicle and experimental ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2021 - Elsevier BV | Journal of Integrative Medicine
Produção Nacional
Revisado por pares
Ruan Carlos Macêdo de Moraes, Guilherme Vannucchi Portari, Alex Soares Marreiros Ferraz, Tiago E. Oliveira, Moacir Marocolo,
Intermittent fasting protocol (IFP) has been suggested as a strategy to change body metabolism and improve health. The effects of IFP seem to be similar to aerobic exercise, having a hormetic adaptation according to intensity and frequency. However, the effects of combining both interventions are still unknown. Therefore, the aim of the present study was to evaluate the effects of IFP with and without endurance-exercise training on body composition, food behavior, and lipid metabolism. Twenty-week- ...
Tópico(s): Diet and metabolism studies
2017 - NRC Research Press | Applied Physiology Nutrition and Metabolism
Produção Nacional
Revisado por pares
Aline Boveto Santamarina, Ruan Carlos Macêdo de Moraes, Victor Nehmi Filho, Gilson Masahiro Murata, Jéssica Alves de Freitas, Danielle Araújo de Miranda, A Cerqueira, Soraia K.P. Costa, Ana Flávia Fernandes Ferreira, Luiz Roberto Britto, Juliana Alves de Camargo, Daniela Rodrigues de Oliveira, Flavia Neto de Jesus, José Pinhata Otoch, Ana Flávia Marçal Pessoa,
The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and isolated compounds. The vehicle and experimental formulations were administered orally by gavage once a day over the four ...
Tópico(s): Biochemical effects in animals
2022 - Multidisciplinary Digital Publishing Institute | Antioxidants
Jonathan R. Roth, Shweta Varshney, Ruan Carlos Macêdo de Moraes, Girish C. Melkani,
Abstract Circadian rhythms are present throughout biology, from the molecular level to complex behaviors such as eating and sleeping. They are driven by molecular clocks within cells, and different tissues can have unique rhythms. Circadian disruption can trigger obesity and other common metabolic disorders such as aging, diabetes, and cardiovascular disease, and circadian genes control metabolism. At an organismal level, feeding and fasting rhythms are key drivers of circadian rhythms. This underscores ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2023 - Wiley | Obesity
Produção Nacional
Revisado por pares
F. Lázaro, Renata Iani Werneck, Ciane Cristina Oliveira Mackert, Aurélie Cobat, Flávia Costa Prevedello, Raphaela P. Pimentel, Geraldo Mariano Moraes de Macêdo, Marco A. Eleuterio, Guilherme Vilar, Laurent Abel, Marília Brasil Xavier, Alexandre Alcaïs, Marcelo Távora Mira,
Leprosy is a chronic infectious disease that affects 250,000 new individuals/year worldwide. Genetic analysis has been successfully applied to the identification of host genetic factors affecting susceptibility to leprosy; however, a consensus regarding its mode of inheritance is yet to be achieved.We conducted a complex segregation analysis (CSA) on leprosy using data from the Prata Colony, an isolated, highly endemic former leprosy community located at the outskirts of the Brazilian Amazon. The ...
Tópico(s): Hematological disorders and diagnostics
2010 - Oxford University Press | The Journal of Infectious Diseases
Produção Nacional
Revisado por pares
Carla Andréa Avelar Pires, Marília Brasil Xavier, Juarez Antônio Simões Quaresma, Geraldo Mariano Moraes de Macêdo, Bruna Ranyelle de Marinho Sousa, Arival Cardoso de Brito,
BACKGROUND: Chromoblastomycosis is a chronic fungal infection caused by fungi from the Dematiaceae family. According to several studies, Fonsecaea pedrosoi is the most common of these fungi. The infection is more common in tropical countries, with the Brazilian state of Pará having one of the largest infected populations worldwide. The disease is difficult to treat and recurrences are common. OBJECTIVES: To describe the epidemiological and mycological aspects of cases of chromoblastomycosis and ...
Tópico(s): Plant Pathogens and Fungal Diseases
2012 - Elsevier BV | Anais Brasileiros de Dermatologia
Produção Nacional
Revisado por pares
Carla Avelar-Pires, Juarez Antônio Simões Quaresma, Geraldo Mariano Moraes-de Macedo, Marilia Brasil-Xavier, Arival Cardoso-de Brito,
Chromoblastomycosis is a chronic fungal infection caused by species of the family Dematiaceae. Fonsecaea pedrosoi is the most common etiological agent. The objective of this study was to describe the epidemiological and mycological profile of patients with chromoblastomycosis from the Amazon region of Brazil and to correlate the clinical forms with the histopathological findings and severity criteria.Sixty-five patients were submitted to mycological (direct, culture, and microculture) and histopathological ( ...
Tópico(s): Infectious Diseases and Mycology
2013 - Elsevier BV | Archives of Medical Research
Produção Nacional
Revisado por pares
Carla Andréa Avelar Pires, Fernando Octávio Machado Jucá Neto, Nahima Castelo de Albuquerque, Geraldo Mariano Moraes de Macêdo, Keila de Nazaré Madureira Batista, Marília Brasil Xavier,
Background Leprosy, caused by Mycobacterium leprae, can lead to scarring and deformities. Human immunodeficiency virus (HIV), a lymphotropic virus with high rates of replication, leads to cell death in various stages of infection. These diseases have major social and quality of life costs, and although the relevance of their comorbidity is recognized, several aspects are still not fully understood. Methodology/Principal Findings Two cohorts of patients with leprosy in an endemic region of the Amazon ...
Tópico(s): Infectious Diseases and Tuberculosis
2015 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Marina Barguil Macêdo, Janaína de Moraes Machado Brito, Plínio da Silva Macêdo, José Araújo Brito,
Bernard-Soulier Syndrome is a rare congenital bleeding disorder, mainly inherited in an autosomal recessive pattern. It is characterized by a genetic defect on one of the four genes encoding the subunits of the transmembrane protein complex GPIb-V-IX, physiologically expressed only in platelets. The exact phenotype varies widely from individual to individual depending on the particular mutation presented. Currently, there is no consensus about ideal management of affected pregnant women, in face ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2015 - BioMed Central | BMC Research Notes
Produção Nacional
Revisado por pares
Ruan Carlos Macêdo de Moraes, Gabriely Cristina Alves Lima, Camila Aparecida Erreiras Fernandes Cardinali, Alisson Carvalho de Gonçalves, Guilherme Vannucchi Portari, Elvira María Guerra-Shinohara, Antoine Leboucher, José Donato, André Kleinridders, Andréa da Silva Torrão,
Tópico(s): Retinoids in leukemia and cellular processes
2022 - Elsevier BV | Life Sciences
Produção Nacional
Revisado por pares
George Jackson de Moraes Rocha, Carlos Martı́n, Isaías Barbosa Soares, Ana Maria Souto Maior, Henrique Macedo Baudel, César Augusto Moraes de Abreu,
Tópico(s): Catalysis for Biomass Conversion
2010 - Elsevier BV | Biomass and Bioenergy
Jonathan R. Roth, Ruan Carlos Macêdo de Moraes, Brittney P. Xu, Savannah R. Crawley, Malghalara A. Khan, Girish C. Melkani,
Huntington's disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2023 - Frontiers Media | Frontiers in Aging Neuroscience
Produção Nacional
Revisado por pares
Isabel Cristina de Macedo, Liciane Fernandes Medeiros, Cleverson Moraes de Oliveira, Cleverson Moraes de Oliveira, Joanna Ripoll Rozisky, Vanessa Leal Scarabelot, Andressa de Souza, F.R. Silva, Vívian da Silva Santos, Stefania Giotti Cioato, Wolnei Caumo, Iraci Lucena da Silva Torres,
Obesity is a disease that has become a serious public health issue worldwide, and chronic stressors, which are a problem for modern society, cause neuroendocrine changes with alterations in food intake. Obesity and chronic stress are associated with the development of cardiovascular diseases and metabolic disorders. In this study, a rat model was used to evaluate the effects of a hypercaloric diet plus chronic restraint stress on the serum leptin and lipids levels and on the weight of specific adipose ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2012 - Elsevier BV | Peptides
Produção Nacional
Revisado por pares
Tainá Carla Freitas de Macêdo, Glescikelly Herminia Ferreira, Katie Moraes de Almondes, Roumen Kirov, Sérgio Mota‐Rolim,
Nightmares are defined as repeated occurrences of extremely dysphoric and well-remembered dreams that usually involve subjective threats to survival, security, or physical integrity. Generally, they occur during rapid eye movement sleep (REMS) and lead to awakenings with distress and insufficient overnight sleep. Nightmares may occur spontaneously (idiopathic) or as recurrent nightmares. Recurrent nightmares cause significant distress and impairment in occupational and social functioning, as have ...
Tópico(s): Memory and Neural Mechanisms
2019 - Frontiers Media | Frontiers in Psychology
Produção Nacional
Revisado por pares
Lucila Emiko Tsugiyama, Ruan Carlos Macêdo de Moraes, Yaslle Andrade Cavalcante Moraes, José Fernando de Oliveira,
Pharmacological treatment of major depressive disorder (MDD) still relies on the use of serotonergic drugs, despite their limited efficacy. A few mechanistically new drugs have been developed in recent years, but many fail in clinical trials. Several hypotheses have been proposed to explain MDD pathophysiology, indicating that physiological processes such as neuroplasticity, circadian rhythms, and metabolism are potential targets. Here, we review the current state of pharmacological treatments for ...
Tópico(s): Psychedelics and Drug Studies
2023 - Elsevier BV | Drug Discovery Today
Produção Nacional
Revisado por pares
Joyce de Cassia Rosa de Jesus, Ariene Murari Soares de Pinho, Katrin Radloff, Ruan Carlos Macêdo de Moraes, Raquel Galvão Figuerêdo, Ana Flávia Marçal Pessoa, José Cesar Rosa Neto, Emídio Marques de Matos‐Neto, Paulo Sérgio Martins de Alcântara, Flávio Tokeshi, Linda Ferreira Maximiano, Fang Chia Bin, Fernanda Bellotti Formiga, José Pinhata Otoch, Marília Seelaender,
Background Cachexia is a paraneoplastic syndrome that accompanies and compromises cancer treatment, especially in advanced stages, affecting the metabolism and function of several organs. The adipose tissue is the first to respond to the presence of the tumor, contributing to the secretion of factors which drive the systemic inflammation, a hallmark of the syndrome. While inflammation is a defensive innate response, the control mechanisms have been reported to be disrupted in cachexia. On the other ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2021 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Luciana Caroline Albuquerque Bezerra, Paulo Germano de Frias, Suely Arruda Vidal, Vilma Costa de Macêdo, Lygia Cármen de Moraes Vanderlei,
This paper analyses the implementation level of a breast-feeding incentive program at Government healthcare facilities in Recife, Pernambuco State, Brazil, through a normative assessment conducted through 84 Family Health Teams and at 42 Health Centers in January 2002. A tool containing structured questions was used, related to rules and routines for promoting breast-feeding. The Family Health Teams performed better, with the actions implemented in 7.1% of these Teams and at none of the Health Centers; ...
Tópico(s): Global Maternal and Child Health
2007 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Cecília Rocha da Silva, João Batista de Andrade Neto, José Júlio Costa Sidrim, Maria Rozzelê Ferreira Ângelo, Hemerson Iury Ferreira Magalhães, Bruno C. Cavalcanti, Raimunda Sâmia Nogueira Brilhante, Danielle S. Macêdo, Manoel Odorico de Moraes, Marina Duarte Pinto Lobo, Thalles B. Grangeiro, Hélio Vitoriano Nobre Júnior,
ABSTRACT There have recently been significant increases in the prevalence of systemic invasive fungal infections. However, the number of antifungal drugs on the market is limited in comparison to the number of available antibacterial drugs. This fact, coupled with the increased frequency of cross-resistance, makes it necessary to develop new therapeutic strategies. Combination drug therapies have become one of the most widely used and effective strategies to alleviate this problem. Amiodarone (AMD) ...
Tópico(s): Plant-Microbe Interactions and Immunity
2013 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Liuski Roger Caballero, Maria das Dores Macedo Paiva, Eduardo de Moraes Rego Fairbairn, Romildo Dias Tolêdo Filho,
In the present work, geopolymer matrices were developed by alkali activation of metakaolin, using NaOH and sodium silicate as activators. The samples of metakaolin and matrices were studied by thermal analysis (TGA/DTA) at temperatures between 22°C and 1000°C in a nitrogen atmosphere with a heating rate of 10°C/min. The analyses showed gradual mass losses for MK1 and MK2, occurring in the temperature range of 350-700°C, associated with the dehydroxylation of the kaolinite present in the metakaolin ...
Tópico(s): Innovative concrete reinforcement materials
2019 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research
Produção Nacional
Revisado por pares
André Maia‐Lima, Guilherme Passos Ramos, Michele Macedo Moraes, Diogo Pacheco, Gustavo de Oliveira, Cristiano de Barros, Luciano Sales Prado, Emerson Silami‐Garcia,
This study examined the effects of precooling on performance and pacing during 30-km cycling exercise in hot and temperate environments. 8 trained male cyclists performed 4 trials involving either cooling (PRECTEMP and PRECHOT) or no-cooling interventions (TEMP and HOT) prior to a 30-km self-paced cycling exercise in either a hot (35°C, 68% relative humidity) or temperate environment (24°C, 68% relative humidity). Exercise time was longer in HOT (60.62±3.47 min) than in TEMP (58.28±3.30 min; P<0.001), ...
Tópico(s): Cardiovascular and exercise physiology
2017 - Thieme Medical Publishers (Germany) | International Journal of Sports Medicine
Produção Nacional
Revisado por pares
Híttalo Carlos Rodrigues de Almeida, Ellane Talita Silvano de SANTANA, Nikácio Adnner Tavares dos Santos, Patrícia Karla Macedo de Moraes, Yasmin Rafaelle Furtado de ARAÚJO, Marleny Elizabeth Márquez de Martínez Gerbi,
Objective: The aim of this study was to criticaly review the published literature regarding the clinical aspects involved in the rehabilitation of edentulous patients using Branemark protocol and overdenture prostheses. Methods: An active search was conducted in the LILACS, MEDLINE, PubMed, and SciELO databases using the descriptors: "Coating for dentures" (Overlay Prosthesis and Overdenture) and "Implant-supported fixed dental prosthesis" (Protesis dental de suporte implantado, Dental prosthesis, and ...
Tópico(s): Tracheal and airway disorders
2015 - CENTRO DE PESQUISAS ODONTOLOGICAS SAO LEOPOLDO MANDIC | RGO - Revista Gaúcha de Odontologia
Produção Nacional
Revisado por pares
Alfredo Macedo Gomes, Karine Numes de Moraes,
O estudo analisa o processo de expansão da educação superior no Brasil nas últimas três décadas, com especial atenção para o período que cobre os governos Fernando Henrique Cardoso e Luis Inácio Lula da Silva. Examinam-se as seguintes questões: podemos afirmar que o Brasil contemporâneo produziu um sistema de massa? Se sim, como e por meio de que políticas têm se processado a mudança para o sistema de educação superior de massa? Para analisar tal problemática nos apoiamos principalmente na perspectiva ...
Tópico(s): Social and Political Issues
2012 - Centro de Estudos Educação e Sociedade | Educação & Sociedade
Produção Nacional
Revisado por pares
Rosimeire Aparecida Mendes Lopes, Denise Diniz Macedo, María Helena Baena de Moraes Lopes,
Este trabalho levanta diagnósticos de enfermagem mais freqüentes, a partir do histórico de enfermagem e procedimento médico, com o objetivo de subsidiar a assistência no Serviço de Enfermagem em Oncologia do Centro de Atenção Integral à Saúde da Mulher (CAISM). Os cinco diagnósticos mais freqüentes foram: potencial para infecção, potencial para temperatura corporal alterada, potencial para aspiração e constipação colônica do padrão trocar, e potencial para intolerância à atividade do padrão mover. ...
Tópico(s): Women's cancer prevention and management
1997 - UNIVERSIDADE DE SÃO PAULO | Revista Latino-Americana de Enfermagem
Produção Nacional
Revisado por pares
Rosana Therezinha Queiroz de Oliveira, Caroline Ferraz Ignacio, Antonio Henrique Almeida de Moraes Neto, Martha Macêdo de Lima Barata,
Resumo A promoção da saúde possui um conjunto de estratégias para trazer saúde e reduzir desigualdades. No entanto, tem sido um desafio avaliar a efetividade de programas de promoção de saúde. Este artigo apresenta o desenvolvimento e a aplicação de Matriz de Avaliação, construída por meio de indicadores quali-quantitativos e multidimensionais, que estão apoiados nas políticas públicas voltadas para territórios com vulnerabilidade social. Estudo transversal, com realização de programa de promoção ...
Tópico(s): Health, Nursing, Elderly Care
2017 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Thaís Bastos Rocha, Ruan da Cruz Paulino, Diego Moraes Soares, Wendel Adelino Policarpo, Silva Filho, Maria Vivina Barros Monteiro, Michelly Fernandes de Macedo, Hélder de Moraes Pereira,
Tópico(s): Reproductive Physiology in Livestock
2021 - Springer Science+Business Media | Tropical Animal Health and Production
Produção Nacional
Revisado por pares
Mariana de Queiroz Brunelli, T. Diana L. van Aduard de Macedo-Soares, Déborah Moraes Zouain, Ana Paula Borges,
This article presents the results of a review of the literature on tourism from 2005 to 2009. Precisely, 1,648 articles were reviewed and classified into eight macro-lines of research. The content of the Strategy macro-line was analyzed in greater depth, as it was considered to be an "umbrella" for the other dimensions pertinent to tourism. The literature thus provided significant elements confirming the appropriateness of the strategic network perspective for research on sustainable tourism management, ...
Tópico(s): Environmental Sustainability in Business
2010 - FUNDAÇÃO GETÚLIO VARGAS | Revista de Administração Pública
Produção Nacional
Revisado por pares
Miguel Luiz Menezes Freitas, Ana Paula de Andrade Aukar, Alexandre Magno Sebbenn, Mário Luiz Teixeira de Moraes, Eliana Gertrudes de Macedo Lemos,
Myracrodruon urundeuva (aroeira) é uma das espécies arbóreas que apresentam madeira de maior durabilidade em contato com o solo. Em razão dessa característica, populações naturais de M. urundeuva, distribuídas por quase todo o Brasil, vêm sendo dizimadas. Desse modo, o presente trabalho teve por objetivo avaliar a expressão da variação genética em uma população natural de M. urundeuva procedente da Estação Ecológica do Instituto Florestal, localizada em Paulo de Faria, SP. Coletaram-se sementes de ...
Tópico(s): Agricultural and Food Sciences
2006 - Sociedade de Investigações Florestais | Revista Árvore