... 682, 683 and 684. Letter. From C. G. Macus. Williamsport Pennsylvania.
0000 - Gale Group | NCCO-STM 1of2
Yan Long, Wen-Bin Tsai, Jeffrey T. Chang, Marcos R. Estecio, Medhi Wangpaichitr, Naramol Savaraj, Lynn G. Feun, Helen H.W. Chen, Macus Tien Kuo,
... G. Feun 4 , Helen H.W. Chen 5 , Macus Tien Kuo 1 1 Department of Translational Molecular ... have contributed equally to this work Correspondence to: Macus Tien Kuo, email: tkuo@mdanderson.org Keywords: cisplatin, ...
Tópico(s): Polyamine Metabolism and Applications
2016 - Impact Journals LLC | Oncotarget
Andrew Robson, Elizabeth Mistry, Thair Shaikh, James Johnson, Andrew Pierce, Patricia Davies, Adam Sherwin Media Reporter, Sarah Potter, Shirley English, Sean O'Neill and Leo Lewis, Paul Hoggart, Richard Hobson, Martin Richards, Nicolette Jones, Michael Evans Defence Editor, Christine Seib, David Chater, Aian Hali, James Bone, Penny Wark, Nic Hopkins, Alexandra Frean Social Affairs Correspondent, Olly Duke, Lucia Van Der Post, Patrick Kidd, Richard Lioyd Parry, Sam Marlowe, Charlie Pryor, Philip Webster, Helen Rumbelow and Greg Hurst, James Maycock, Geoff Brown, Andrew Norfolk, David Sharrock, Ben Webster Transport Correspondent, John Clarke, Henry Harris, Frances Gibb legal Editor, Donald Hutera, Anne Spackman Property Editor, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Steve Bird, Shirley English, Gary Jacob, Norman Harris, Jennifer Miller, Dan Sabbagh, Dalya Alberge Arts Correspondent, Stephen Farrell, Alan Hamilton, Jenny MacArthur, James Schadla-Hall, Sian Morgân, Valerie Elliott Consumer Editor, Roland Watson, Jonathan Richards, Josephine Smit, Mark Ogden, Nicholas Wapshott, Susan Emmett, Martin Penner, Russell Kempson, Daniel McGrory, John Westerby, Michael Theodoulou, Neil Harman, Bernard Tierney, Tom Baldwin, Sam Coates, Ann Treneman, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Elaine Monaghan, J. P. Webster, Dan Sabbagh Telecoms Correspondent, Marcus Binney, Raymond Keene, Matthew Pryor, Jonathan Clayton and Michael Pflanz, Robert Andrews, Nigel Hawkes, Neville Scott, Chris Campling, Helen Nugent, Colin S. Jeffery, Ian J. Hartill, Malcolm Bowden, Oliver August, Peter Dixon, Tony Boulton, Andrew Norfolk and Nigel Hawkes, Adam Fresco, Dominic Kennedy, Philip Webster and Greg Hurst, Robin Kempster, Jane Shilling, Mel Webb, Craig Lord, Mike Berry, John MacAskill, David M. Connors, Ingrid Mansell, Caitlin Moran, Alan Lee, Peter Riddell, Brian Murgatroyd, Ben Webster, Pat Gilbson, David Charter Chief Political Correspondent, David Sinclair, Gary Duncan Economics Correspondent, Catherine Philp, Martin Waller, Chris Ayres, Antje Derks, Carl Mortished International Business Editor, Ashling O'Connor, Norman McCanch, Carl Chambers, Stephen Dalton, Richard Morrison, Frances Gibb, Simon and Garfunkel, Paul Pickering, Margaret P. Pearce, Adam Sherwin, Paul Bartlett, lan MacKinnon, Conal Gregory, Eve Marks, Abigail Rayner and Dan Sabbagh, Lisa Verrico, Tony halpin Eduction Editor, Jane Jackman,
... mikman's mansion, leaks a little, but charms Macus Binney One we Made Earlier Yesterday's classic ...
2004 - Gale Group | TDA
Nicolay Jonassen Harbin, Morten Lindbæk, Maria Romøren,
... prescribing in NHs and municipal acute care units (MACUs) is essential to ensure the most adequate antibiotic ... nurses ( n = 14) in 10 NHs and 3 MACUs located in the county of Østfold, Norway. We ... of appropriate antibiotic prescribing in Norwegian NHs and MACUs. Diagnostic uncertainty, frequent dialogue with next of kin ...
Tópico(s): Urinary Tract Infections Management
2022 - BioMed Central | BMC Geriatrics
Alan Day, Victoria McKee, Colin McQuilan, John Beishon, Peter Green, Simon Barnes, Jasper Rees, Stephen Leather, Diana Wildman, Sheridan Morley, Ivo Tennant, Zahid Hussein, Angela MacKay, Brian Wenham, Sally Brompton, Nick Worrall, Michael Binyon, Cornelis J. de Jong, Sarada Bay, Richard Evans, Media Editor, Carol Leonard, Dessa Trevisan, Richard Eaton, Rosemary Attack, Stuart Jones Football Correspondent, Sonny Sharrock, Ray Clancy, Michael Seely Racing Correspondent, Martin Fletcher, Henry Gee, Noel Falconer, Mitchell Platts, Golf Correspondent, Peter Davenport, Stuart Sexton, Peter Dawson, General Secretary, Raymond Keene Chess Correspondent, Louise Taylor, Alexandra King, Thomson Prentice Science Correspondent, David Tytler Education Editor, Douglas Broom, Robin Young, Alan Hamilton, Nicholas Watt, Michael Clark, Thomson Prentice, Science Correspondent, Philip Robinson, John Young, Lawrie Smith, Charles Bremner, Neil Bennett Banking Correspondent, David Stevenson, John Hennessy, Thomson Prentice, Simon Tait, Harvey Elliott, Air Correspondent, Nicole Swengley, John Woodcock, G. V. Bull, Dennis Signy, David Holbrook, Philip Webster, Chief Political Correspondent, (Michael Phillips), Sandy Bisp, Andrew McEwen, Diplomatic Editor, Marcus Binney, Gavin Bell and Andrew McEwen, Kerry Gill, David Robinson, Peter Davalle, Dr J. Aldridge-Goult, Alan Lee, Cricket Correspondent, Craig Brown, Paul A. Philpot, Martin Fletcher and Philip Webster, Paul Griffiths, Steve Acteson, Los Angeles, Ewald Junge, Richard Evans, Craig Seton, J. M. K. Laing, David Powell, Athletics Correspondent, Peter Dear and Gillian Maxey, Joyce Whitehead, Ronald Faux and Quentin Cowdry, Roger Boyes, Ronald Butt, Roger Boyes Warsaw, Richard Bassett, Brian Beel, Derek Harris, Industrial Editor, Simon Tait, Arts Correspondent, Michael Dynes, Transport Correspondent, Jamie Dettmer, Christopher Thomas, Christopher Warman Property Correspondent, F. Ellis, David Young, Peter Ball Malta, Philip Webster Chief Political Correspondent, Antony Randle, Mandarin, J. J. Graham, P. L. P. Clarke, George Hill, Clive White, Michael Seely, Keith Blackmore, Anatol Lieven and Our Foreign Staff, Alan Lee Cricket Correspondent, David Sinclair, Melinda Wittstock, Martin Waller, Douglas Broom and David Tytler, Benedict Nightingale, Quentin Cowdry, Home Affairs Correspondent, David Tytler, Education Editor, Rodney Lord, Economics Editor, Richard Morrison, Jack Bailey, Steve Turner, Anne McElvoy, William H. Barker (Associate Professor of Gerontology and Community Medicine), Pearce Wright, Science Editor, Peter Dolton, Matthew Bond, Harvey Elliott Air Correspondent, Susan Ellicott, Andrew Longmore, Tennis Correspondent,
... gap Times Diary Kindness that ruins our cathedrals Macus Binney warns against the damage wrought by enthusiastic ...
1990 - Gale Group | TDA
Niramol Savaraj, Chunjing Wu, Yingying Li, Medhi Wangpaichitr, Min You, John S. Bomalaski, Wei He, Macus Tien Kuo, Lynn G. Feun,
... You 3 , John Bomalaski 4 , Wei He 4 , Macus Tien Kuo 5 and Lynn G. Feun 2 ...
Tópico(s): Cancer-related Molecular Pathways
2015 - Impact Journals LLC | Oncotarget
Medhi Wangpaichitr, Chunjing Wu, Ying Ying Li, Dan J.M. Nguyen, Hande Kandemir, Sumedh S. Shah, Shu‐Mei Chen, Lynn G. Feun, Jeffrey S. Prince, Macus Tien Kuo, Niramol Savaraj,
... Lynn G. Feun 3 , Jeffrey S. Prince 4 , Macus T. Kuo 7 and Niramol Savaraj 1, 3 ...
Tópico(s): Nanoplatforms for cancer theranostics
2017 - Impact Journals LLC | Oncotarget
Ying-Ying Li, Chunjing Wu, Shu‐Mei Chen, Sumedh S. Shah, Medhi Wangpaichitr, Lynn G. Feun, Macus Tien Kuo, Miguel Ángel Cabrera Suárez, Jeffrey S. Prince, Niramol Savaraj,
... Medhi Wangpaichitr 3, 7 , Lynn G. Feun 2 , Macus T. Kuo 8 , Miguel Suarez 9 , Jeffrey Prince ...
Tópico(s): Ubiquitin and proteasome pathways
2016 - Impact Journals LLC | Oncotarget
Charles W. Haidle, Macus Tien Kuo, Karolyn Kay Weiss,
Tópico(s): Synthesis and Biological Evaluation
1972 - Elsevier BV | Biochemical Pharmacology
J�rge J. Yunis, Macus Tien Kuo, Grady F. Saunders,
Tópico(s): RNA Research and Splicing
1977 - Springer Science+Business Media | Chromosoma
Liang Zheng, David W. Stockton, Niramol Savaraj, Macus Tien Kuo,
The human high-affinity copper transporter (hCtr1) plays an important role in the regulation of intracellular copper homeostasis. hCtr1 is involved in the transport of platinum-based antitumor agents such as cisplatin (CDDP); however, the mechanisms that regulate hCtr1-mediated transport of these agents have not been well elucidated. We compared the mechanisms of hCtr1-mediated transport of copper and CDDP. We found that replacements of several methionine residues that are essential for hCtr1-mediated ...
Tópico(s): Drug Transport and Resistance Mechanisms
2009 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Wen-Bin Tsai, Isamu Aiba, Soo‐Yong Lee, Lynn G. Feun, Niramol Savaraj, Macus Tien Kuo,
Abstract Arginine deiminase (ADI)–based arginine depletion is a novel strategy under clinical trials for the treatment of malignant melanoma with promising results. The sensitivity of melanoma to ADI treatment is based on its auxotrophy for arginine due to a lack of argininosuccinate synthetase (AS) expression, the rate-limiting enzyme for the de novo biosynthesis of arginine. We show here that AS expression can be transcriptionally induced by ADI in melanoma cell lines A2058 and SK-MEL-2 but not ...
Tópico(s): Virus-based gene therapy research
2009 - American Association for Cancer Research | Molecular Cancer Therapeutics
Xiaoxiang Guan, Yucai Wang, Ruilian Xie, Longbang Chen, Jianling Bai, Jia Lu, Macus Tien Kuo,
The aim of this study was to comprehensively evaluate via a meta-analysis the association between p27 expression and clinical outcome in breast cancer patients. We conducted a meta-analysis of 20 studies (n= 6463 patients) that evaluated the correlation between p27 expression and indicators of breast cancer clinical outcome, including overall survival (OS), disease-free survival (DFS) and relapse-free survival (RFS). Data pooling was performed by RevMan 4.2. A total of 60% (9 of 15) of the studies showed ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2009 - Wiley | Journal of Cellular and Molecular Medicine
Anuradha Dutt, Teresa S. Priebe, Larry D. Teeter, Macus Tien Kuo, J. Arly Nelson,
The apical surface of the proximal tubular epithelium is the site of both P-glycoprotein localization and postulated active secretion of organic cations in the mammalian kidney. P-glycoprotein has been shown to act as a pleiotropic drug efflux pump across the cell membrane of tumor cells expressing the multidrug resistance phenotype, whereas the renal organic anion and organic cation secretory systems serve the function of pleiotropic drug transport across the proximal tubule epithelium. Because ...
Tópico(s): Pharmacogenetics and Drug Metabolism
1992 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Macus Tien Kuo, Zesheng Liu, Yingjie Wei, Yen-Chiu Lin-Lee, Shigeru Tatebe, Gordon B. Mills, Hitoshi Unate,
Tópico(s): Cancer-related Molecular Pathways
2002 - Springer Nature | Oncogene
Niramol Savaraj, Chunjing Wu, Medhi Wangpaichitr, Macus Tien Kuo, Théodore J. Lampidis, Carlos Robles, A Fürst, Lynn G. Feun,
Cisplatin (CDDP) resistance is one of the major impediments in cancer chemotherapy. In an attempt to define this complex mechanism(s) of resistance, we have identified 7 cDNA fragments which are overexpressed in CDDP resistant small cell lung cancer cell line (SR-2) using PCR selected cDNA subtraction. One of these fragments was identical with nucleotide 3657-4042 of MRP4. The other fragments share sequence homology with elongation factor α, human placenta villi cDNA, heat shock protein (Hsp70), ribosomal ...
Tópico(s): Epigenetics and DNA Methylation
2003 - Spandidos Publishing | International Journal of Oncology
The development of multidrug resistance to cancer chemotherapy is a major obstacle to the effective treatment of human malignancies. It has been established that membrane proteins, notably multidrug resistance (MDR), multidrug resistance protein (MRP), and breast cancer resistance protein (BCRP) of the ATP binding cassette (ABC) transporter family encoding efflux pumps, play important roles in the development of multidrug resistance. Overexpression of these transporters has been observed frequently ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2008 - Mary Ann Liebert, Inc. | Antioxidants and Redox Signaling
Isamu Aiba, Anwar Hossain, Macus Tien Kuo,
Cadmium is a nonessential toxic metal in mammals. Its toxicity is mainly caused by interactions with cellular proteins that result in protein dysfunction and then disturb normal cellular functions. Glutathione (GSH) has been reported to play a role in cadmium resistance by serving as a cofactor for multidrug resistance protein 1/GS-X pump-mediated cadmium elimination. To further investigate the role of GSH in cadmium toxicity, we carried out a comparative study using small-cell lung cancer-derived ...
Tópico(s): Drug Transport and Resistance Mechanisms
2008 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Im‐Sook Song, Helen H.W. Chen, Isamu Aiba, Anwar Hossain, Liang Zheng, Leo W. J. Klomp, Macus Tien Kuo,
Copper is an essential metal nutrient, yet copper overload is toxic. Here, we report that human copper transporter (hCtr) 1 plays an important role in the maintenance of copper homeostasis by demonstrating that expression of hCtr1 mRNA was up-regulated under copper-depleted conditions and down-regulated under copper-replete conditions. Overexpression of full-length hCtr1 by transfection with a recombinant hCtr1 cDNA clone reduced endogenous hCtr1 mRNA levels, whereas overexpression of N terminus- ...
Tópico(s): Drug Transport and Resistance Mechanisms
2008 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Multitheoretic board research and research on board processes have, to date, been pursued in isolation. I argue that board interactions can serve as the conceptual basis for a combination of these two approaches to board research. I argue that board composition and board structure merely endow the board with a certain potential to contribute to firm performance but do not ensure that this potential actually comes to bear. Based on the insights from social psychology and group research, I propose ...
Tópico(s): Management and Organizational Studies
2008 - Taylor & Francis | International Studies of Management and Organization
Helen Chen, Im‐Sook Song, Anwar Hossain, Min‐Koo Choi, Y Yamane, Liang Zheng, Jia Lu, Lily Y. H. Wu, Zahid H. Siddik, Leo W. J. Klomp, Niramol Savaraj, Macus Tien Kuo,
Previous studies have demonstrated that treating cultured cells with cisplatin (CDDP) up-regulated the expression of glutathione (GSH) and its de novo rate-limiting enzyme glutamate-cysteine ligase (GCL), which consists of a catalytic (GCLC) and a modifier (GCLM) subunit. It has also been shown that many CDDP-resistant cell lines exhibit high levels of GCLC/GCLM and GSH. Because the GSH system is the major intracellular regulator of redox conditions that serve as an important detoxification cytoprotector, ...
Tópico(s): Drug Transport and Resistance Mechanisms
2008 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Macus Tien Kuo, Niramol Savaraj, Lynn G. Feun,
It has been shown that a subset of human cancers, notably, melanoma and hepatocellular carcinoma (HCC) are auxotrophic for arginine (Arg), because they do not express argininosuccinate synthetase (ASS), the rate-limiting enzyme for the biosynthesis of arginine from citrulline.These ASS-negative cancer cells require Arg from extracellular sources for survival.When they are exposed to recombinant Arg-degrading enzymes, e.g.arginine deiminase (ADI) or arginase, they die because of Arg starvation; whereas ...
Tópico(s): Virus-based gene therapy research
2010 - Impact Journals LLC | Oncotarget
Helen H.W. Chen, Macus Tien Kuo,
Three mechanisms have been proposed for the role of glutathione (GSH) in regulating cisplatin (CDDP) sensitivities that affects its ultimate cell-killing ability: (i) GSH may serve as a cofactor in facilitating multidrug resistance protein 2- (MRP2-) mediated CDDP efflux in mammalian cells, since MRP2-transfected cells were shown to confer CDDP resistance; (ii) GSH may serve as a redox-regulating cytoprotector based on the observations that many CDDP-resistant cells overexpress GSH and γ-glutamylcysteine ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2010 - Hindawi Publishing Corporation | Metal-Based Drugs
Macus Tien Kuo, Helen H.W. Chen, Im‐Sook Song, Niramol Savaraj, Toshihisa Ishikawa,
Tópico(s): Metal complexes synthesis and properties
2007 - Springer Science+Business Media | Cancer and Metastasis Reviews
Liang Zheng, Wen-Bin Tsai, Mei-Yi Lee, Niramol Savaraj, Macus Tien Kuo,
Copper is an essential micronutrient for cell growth but is toxic in excess. Copper transporter (Ctr1) plays an important role in regulating adequate copper levels in mammalian cells. We have shown previously that expression of the human high-affinity copper transporter (hCtr1) was transcriptionally up-regulated under copper-depleted conditions and down-regulated under replete conditions; moreover, elevated hCtr1 levels suppress hCtr1 expression. Specificity protein 1 (Sp1) regulates expression of ...
Tópico(s): Drug Transport and Resistance Mechanisms
2011 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Helen H.W. Chen, Jiang Yan, Wen-Chung Chen, Macus Tien Kuo, Yu-Hsuan Lai, Wu Wei Lai, Hsiao‐Sheng Liu, Wu‐Chou Su,
Recent studies have shown that human copper transporter 1 (hCtr1), the major copper influx transporter, is involved in the transport of platinum-based antitumor agents. We investigated the predictive and prognostic values of hCtr1, and copper efflux transporters ATP7A and ATP7B, in patients with locally advanced non-small cell lung cancer (NSCLC) receiving first-line platinum-based chemotherapy.From 2004 to 2009, we identified 54 consecutive stage III NSCLC patients who underwent first-line platinum- ...
Tópico(s): Metal complexes synthesis and properties
2011 - Elsevier BV | Lung Cancer
Anwar Hossain, Molly J. Nixon, Macus Tien Kuo, Grady F. Saunders,
WT1 was originally identified as an inactivated gene in Wilms tumor, a childhood kidney cancer. Alternative splicing of the WT1 transcript generates four major protein isoforms, each having different functional properties. Here we characterized a short transcript originating from a second promoter located within intron 1 of WT1. This 2.3-kb sWT1 transcript encodes a protein of approximately 35-37 kDa that retains intact DNA-binding and transactivation domains but lacks the 147 amino acids at the ...
Tópico(s): Renal and related cancers
2006 - Elsevier BV | Journal of Biological Chemistry
Anwar Hossain, Macus Tien Kuo, Grady F. Saunders,
MicroRNAs are an extensive family of ∼22-nucleotide-long noncoding RNAs expressed in a wide range of eukaryotes, including humans, and they are important in development and disease. We found that microRNA Mir-17-5p has extensive complementarity to the mRNA of AIB1 (named for “amplified in breast cancer 1”). Cell culture experiments showed that AIB1 expression was downregulated by Mir-17-5p, primarily through translational inhibition. Expression of Mir-17-5p was low in breast cancer cell lines. We also ...
Tópico(s): MicroRNA in disease regulation
2006 - Taylor & Francis | Molecular and Cellular Biology
Siqing Fu, Aung Naing, Caroline Fu, Macus Tien Kuo, Razelle Kurzrock,
Abstract Low levels of human copper transporter 1 (hCtr1) mRNA are associated with a shorter progression-free survival after platinum-based therapy. Pretreatment with a copper-lowering agent such as trientine enhanced hCtr1-mediated platinum uptake. Therefore, we conducted a pilot study (NCT01178112) of carboplatin and trientine with the goal of resensitizing patients with advanced cancer to platinum chemotherapy. This case report reviews the outcomes of 5 patients with platinum-resistant high-grade ...
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - American Association for Cancer Research | Molecular Cancer Therapeutics
Wen-Bin Tsai, Isamu Aiba, Yan Long, Hui‐Kuan Lin, Lynn G. Feun, Niramol Savaraj, Macus Tien Kuo,
Melanomas and other cancers that do not express argininosuccinate synthetase (AS), the rate-limiting enzyme for arginine biosynthesis, are sensitive to arginine depletion with pegylated arginine deiminase (ADI-PEG20). However, ADI resistance eventually develops in tumors because of AS upregulation. Although it has been shown that AS upregulation involves c-Myc, the underlying mechanisms remain unknown. Here we show that ADI-PEG20 activates Ras signaling and the effector extracellular signal-regulated ...
Tópico(s): Cancer-related Molecular Pathways
2012 - American Association for Cancer Research | Cancer Research