Liz Hurley, Giles Smith, Richard Mabey, Andrew Robson, Janice Turner, Chris Addison, Christina Hardyment, Cath Urquhart, Robert Cole, SA, Alexandra Frean, Tim Albone, Jeffrey Podolski, Frances Gibb Legal Editor, Jane MacQuitty, Simon Barnes, Amanda Ursell, Alexandra Blair, Mary Murray, Jill Hartley, Paul Hoggart, Mark Souster, Mark Frary, John Mulvey, Professor David Starkey, Jane Knight, Clare Lazaro, Alexandra Frean Education Editor, Michael Evans Defence Editor, Dr Toby Murcott, Second Lieutenant Walter Tull 1st Football Battalion of the Middlesex Regiment (1914-18), Philip Howard, Hannah Betts, Melanie Rickey, Christine Seib, David Irvine, David Chater, Ben Hoyle Arts Reporter, Kate Wighton, James Bone, James Ducker, Melissa Katsoulis, Tina Gaudoin, Style Director, Prue White, Clive Davis, Rachel Campbell-Johnston, Richard Hobson One-Day Cricket Correspondent, Gabrielle Starkey, Jane Taylor-Hayhurst, Will Pavia, Graham Stewart, Richard Eaton, Angus MacLeod Scottish Political Editor, Wendy Ide, John Bungey, Kevin Eason, Diane Hagan, GrÁinne Gilmore, Giles Coren, Vivienne Parry, Fabien Baron, Helen Rappaport, Dr Copperfield, Kate Confrey, Nancy Durrant, Matt Sandy, Ann Widdecombe, Rob Crilly, Vinny Lee, Nicholas Royle, Stewart Tendler Crime Correspondent, Joe Hill, Jack Malvern, Tom Bawden, Debra Craine, Rory Watson, Gary Jacob, Mike Pattenden, Tom Charity, Victoria Segal, Allan Simmons, Christopher Durant, Dr Jane Collins, Tim Reid, Daniel Finkelstein, Cali Mackrill, Jill Dupleix, Dan Sabbagh, Jeanette Winterson, Richard Need, Jo Morris, Alan Hamilton, David Sharrock Ireland Correspondent, Doug Johnstone, Peter Millar, Elizabeth Colman, Caitlin Moran, Nick Wyke, Alan MacKesy, Rhys Blakely, Valerie Elliott Consumer Editor, Richard Lloyd Parry, Peter Davies, David Hands, Naomi Campbell, Charles Bremner, Tina Gaudoin, Michael Glover, Guillem Balague, Adam Sherwin Media Correspondent, Helen Rumbelow, Matt Dickinson Chief Football Correspondent, Genevieve Fox, David Charter, James Clarke picture editor, Neil Fisher, Derwent May, Tim Teeman, Kate Muir, Hugh Montgomery, Russell Kempson, Isobel Shepherd Smith, Ed Potton, Dan Stevens, Henry Shukman, Stephen Anderton, Martin Johnson, Linda Nice, David Lister, John O'byrne, Jack Shamash, John Westerby, Mark Atherton, James Harding Business Editor, Rick Broadbent, Angus Donald, Jane Wheatley, Rob Morgan, James Rossiter, Margaret Beckett, Sam Coates, Pete Paphides, Sally Baker, David Lawrenson, Antonia Senior Personal Finance Editor, Jane Knight Deputy Travel Editor, David Robertson Business Correspondent, Neel Mukherjee, Simon de Bruxelles, Rob Wright, Christina Koning, Magnus Grimond, Trudi Benjamin, Neil Harman Tennis Correspondent, Raymond Keene, Deborath Brett, Suzi Godson, Kate Saunders, Matthew Pryor, Santa Montefiore Aristocratic Author, Richard Brass, Matt Hughes, Rebecca O'Connor, Amanda Bellan, Gordon Ramsay, Tom Benyon, Jeannette Hyde, Kaveh Solhekol, Tony Lawton, Nigel Hawkes, Rick Jones, Chris Campling, Nick Knowles, Richard Owen, Malcolm Bowden, Marcus Leroux, Rebecca O'connor, Ross Leckie, Richard Milne, Erica Wagner, Jeremy Paxman, Marcel Berlins, Peter Marinello, Nick Hasell, Gabriel Rozenberg Economics Reporter, Barbara Lantin, Thomasina Miers, Allan Mallinson, Stewart Tendler, Graham Searjeant Personal Investor, Ellie Levenson, Michael Regan, Ned Parker, David Hands Rugby Correspondent, Nigel Farage, Tom Dart, Ruth Scurr, Paul Simons, Carolyn Asome, Michael Herman, Kerry Baggott, Nicholas Clee, Fiona Sims, Steve Jelbert, Nigel Kendall, Joanna Pitman, ChiloË Bryan-Brown, George Cazenove, Jonathan Clayton, James Doran, Giles Whittell, Robert Crampton, Steve Hawkes, Thomas Catán, Ian Johns, Liam Barlow, Dominic Maxwell, Roderick Strange, Matthew Parris, Edward Marsh, Mark Bridge, Virginia Blackburn, David Crossland, David Heath, Saad Abdul Wahab, Amanda Craig, George Caulkin, Sonia Verma, Alison Steed, Tim Wapshott, Corporal Sasha Atkinson, Russell Jenkins, Dearbail Jordan, Former Regimental Sergeant-Major Owen Lewis, Alan Lee, Celia Dodd, Iain Finlayson, Anthony Loyd, Major Tikendra Dewan, Ben MacIntyre, Andrew Ellson, Helen Pridham, Richard Morrison Chief Music Critic, Tony Dawe, John W. G. Inge, Rob Nash, David Hutcheon, Philippe Saint-Andre, John Naish, Martin Waller, Lewis Smith Environment Reporter, Chris Ayres, Perry Cleveland-Peck, Sandra Ionno Butcher, Ashling O'Connor, Louise Cohen, Benedict Nightingale, Katharine Hamnett, Angus Batey, Dr Thomas Stuttaford, Riad Romance, Jill Crawshaw, Stephen Dalton, Peter Smith, Adrian Milledge, Frances Gibb, Tom Chesshyre, Tony Halpin, Alice Miles, John Pugh, Chris Moore, Adam Sherwin, Richard Morrison, Simon Crompton, James Christopher, Jonathan Goodwin, Shusha Guppy, Alan Lee Racing Correspondent, Olav Bjortomt, Andy Lines, James Harkin, Miles Costello, Fiona Hamilton, Emma Duncan Deputy Editor, Bryce Elder, Joe Bolger, Ian Holloway, Christopher Irvine, Elizabeth Judge Telecoms Correspondent, Tim Bullamore,
... the Wedding Director: Susanne Bier, 15,110min Stars: Mads Mikkelsen, Rolf Lassgard On general release Inland Empire Director: ...
2007 - Gale Group | TDA
Steven Arild Wuyts Andersen, Mads Juhl Guldager, Peter Trier Mikkelsen, Mads Sølvsten Sørensen,
Tópico(s): Shoulder Injury and Treatment
2019 - Springer Science+Business Media | European Archives of Oto-Rhino-Laryngology
Michael E. Crawford, P Carl, Vagn Bach, O Ravlo, B. Mikkelsen, Mads U. Werner,
Crawford, M. E.; Carl, P.; Bach, V.; Ravlo, O.; Mikkelsen, B. O.; Werner, M. Author Information
Tópico(s): Nausea and vomiting management
1989 - Lippincott Williams & Wilkins | Obstetric Anesthesia Digest
Trine Mikkelsen, Mads U. Werner, Birgit Lassen, Henrik Kehlet,
Inguinal hernia repair is associated with a 5%-30% incidence of chronic pain, but the pathogenesis remains unknown. We therefore evaluated pain and sensory dysfunction by quantitative sensory testing 6-12 mo after open hemiorrhaphy. Before sensory testing, all patients (n = 72) completed a short-form McGill Pain Questionnaire and a functional impairment questionnaire. Sensory dysfunction in the incisional area was evaluated by quantification of thermal and mechanical thresholds, by mechanical pain ...
Tópico(s): Pediatric Pain Management Techniques
2004 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Tomas Bohr, Martin van Hecke, René Mikkelsen, Mads Ipsen,
We show that the transition from laminar to active behavior in extended chaotic systems can vary from a continuous transition in the universality class of directed percolation with infinitely many absorbing states to what appears as a first-order transition. The latter occurs when finite lifetime nonchaotic structures, called "solitons," dominate the dynamics. We illustrate this scenario in an extension of the deterministic Chaté-Manneville coupled map lattice model and in a soliton including variant ...
Tópico(s): Stochastic processes and statistical mechanics
2001 - American Physical Society | Physical Review Letters
Daniel Nyberg Larsen, Christian Engelbrecht Mikkelsen, Mads Kierkegaard, Grzegorz Bereta, Zuzanna Nowakowska, Jakub Zbigniew Kaczmarek, Jan Potempa, Peter Højrup,
Porphyromonas gingivalis is a key pathogen in chronic periodontitis and has recently been mechanistically linked to the development of rheumatoid arthritis via the activity of peptidyl arginine deiminase generating citrullinated epitopes in the periodontium. In this project the outer membrane vesicles (OMV) from P. gingivalis W83 wild-type (WT), a W83 knock-out mutant of peptidyl arginine deiminase (ΔPPAD), and a mutant strain expressing PPAD with the active site cysteine mutated to alanine (C351A), ...
Tópico(s): Peptidase Inhibition and Analysis
2019 - Elsevier BV | Molecular & Cellular Proteomics
Steven Arild Wuyts Andersen, Peter Trier Mikkelsen, Mads Sølvsten Sørensen,
Objective Often the assessment of mastoidectomy performance requires time‐consuming manual rating. Virtual reality (VR) simulators offer potentially useful automated assessment and feedback but should be supported by validity evidence. We aimed to investigate simulator metrics for automated assessment based on the expert performance approach, comparison with an established assessment tool, and the consequences of standard setting. Methods The performances of 11 experienced otosurgeons and 37 otorhinolaryngology ...
Tópico(s): Radiology practices and education
2019 - Wiley | The Laryngoscope
Andreas Frithioff, Martin Frendø, Peter Trier Mikkelsen, Mads Sølvsten Sørensen, Steven Arild Wuyts Andersen,
Tópico(s): Virtual Reality Applications and Impacts
2020 - Springer Science+Business Media | European Archives of Oto-Rhino-Laryngology
Michael E. Crawford, Peder Carl, Vagn Bach, O Ravlo, B. Mikkelsen, Mads Werner,
In a randomized blind trial midazolam (0.3 mg kg−1) was compared with thiopental (4 mg kg−1), both combined with meperidine-nitrous oxide, for elective cesarean section anesthesia in 40 women. We found no statistically significant differences between thiopental and midazolam at induction, during operation or recovery with regard to maintenance doses, change in maternal neurologic status based on a modified Glasgow Coma Scale, systolic blood pressure, and heart rate. Induction time was 120 seconds ...
Tópico(s): Nausea and vomiting management
1989 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Steven Arild Wuyts Andersen, Peter Trier Mikkelsen, Mads Sølvsten Sørensen,
Introduction Simulation-integrated tutoring in virtual reality (VR) simulation training by green lighting is a common learning support in simulation-based temporal bone surgical training. However, tutoring overreliance can negatively affect learning. We therefore wanted to investigate the effects of simulator-integrated tutoring on performance and learning. Methods A prospective, educational cohort study of a learning intervention (simulator-integrated tutoring) during repeated and distributed VR ...
Tópico(s): Radiology practices and education
2020 - Lippincott Williams & Wilkins | Simulation in Healthcare The Journal of the Society for Simulation in Healthcare
Andreas Frithioff, Martin Frendø, Josefine Hastrup von Buchwald, Peter Trier Mikkelsen, Mads Sølvsten Sørensen, Steven Arild Wuyts Andersen,
Abstract Objective This study aimed to investigate the effects of automated metrics-based summative feedback on performance, retention and cognitive load in distributed virtual reality simulation training of mastoidectomy. Method Twenty-four medical students were randomised in two groups and performed 15 mastoidectomies on a distributed virtual reality simulator as practice. The intervention group received additional summative metrics-based feedback; the control group followed standard instructions. ...
Tópico(s): Anatomy and Medical Technology
2021 - Cambridge University Press | The Journal of Laryngology & Otology
Philip J. Larsen, Jens D. Mikkelsen, Søren Mads Mau, Torben Særmark,
Substance P binding to cultured anterior pituitary cells was characterized using Bolton-Hunter iodinated substance P as a ligand. At 0 ° C, the interaction of the ligand and the cellular surface binding sites was found to be specific, rapid and reversible. Scatchard and Hill analysis of specific binding revealed a single class of non-interacting binding sites with a high affinity (KD = 0.48 nM) and a moderate density of binding sites (Bmax = 1187 bindingsites/cell). At 37 ° C a NaOH-soluble intracellular ...
Tópico(s): Biochemical and Structural Characterization
1989 - Elsevier BV | Molecular and Cellular Endocrinology
Sebastian Buhl Rasmussen, Lars Konge, Peter Trier Mikkelsen, Mads Sølvsten Sørensen, Steven Arild Wuyts Andersen,
Cognitive load (CL) theory suggests that working memory can be overloaded in complex learning tasks such as surgical technical skills training, which can impair learning. Valid and feasible methods for estimating the CL in specific learning contexts are necessary before the efficacy of CL-lowering instructional interventions can be established. This study aims to explore secondary task precision for the estimation of CL in virtual reality (VR) surgical simulation and also investigate the effects of ...
Tópico(s): Human-Automation Interaction and Safety
2015 - SAGE Publishing | Evaluation & the Health Professions
Martin Frendø, Andreas Frithioff, Lars Konge, Søren Foghsgaard, Peter Trier Mikkelsen, Mads Sølvsten Sørensen, Per Cayé‐Thomasen, Steven Arild Wuyts Andersen,
Tópico(s): Anatomy and Medical Technology
2021 - Springer Science+Business Media | European Archives of Oto-Rhino-Laryngology
Stine Ulrik Mikkelsen, Lasse Kjær, Mads Emil Bjørn, Trine Alma Knudsen, Anders Lindholm Sørensen, Christen Lykkegaard Andersen, Ole Weis Bjerrum, Nana Brochmann, Daniel El Fassi, Torben A. Kruse, Thomas Stauffer Larsen, Hans Torben Mourits‐Andersen, Claus Henrik Nielsen, Niels Pallisgaard, Mads Thomassen, Vibe Skov, Hans Carl Hasselbalch,
Abstract Interferon‐α2 reduces elevated blood cell counts and splenomegaly in patients with myeloproliferative neoplasms ( MPN ) and may restore polyclonal hematopoiesis. Its use is limited by inflammation‐mediated toxicity, leading to treatment discontinuation in 10‐30% of patients. Ruxolitinib, a potent anti‐inflammatory agent, has demonstrated benefit in myelofibrosis ( MF ) and polycythemia vera ( PV ) patients. Combination therapy ( CT ) with these two agents may be more efficacious than monotherapy with either, ...
Tópico(s): Eosinophilic Disorders and Syndromes
2018 - Wiley | Cancer Medicine
Ulrik Kristoffer Stoltze, Jon Foss-Skiftesvik, Thomas van Overeem Hansen, Anna Byrjalsen, Astrid Sehested, David Scheie, Torben Stamm Mikkelsen, Simon Rasmussen, Mads Bak, Henrik Okkels, Michael Thude Callesen, Jane Skjøth‐Rasmussen, Anne–Marie Gerdes, Kjeld Schmiegelow, René Mathiasen, Karin Wadt,
Abstract Background The etiology of central nervous system (CNS) tumors in children is largely unknown and population-based studies of genetic predisposition are lacking. Methods In this prospective, population-based study, we performed germline whole-genome sequencing in 128 children with CNS tumors, supplemented by a systematic pedigree analysis covering 3543 close relatives. Results Thirteen children (10%) harbored pathogenic variants in known cancer genes. These children were more likely to have ...
Tópico(s): Chromatin Remodeling and Cancer
2022 - Oxford University Press | Neuro-Oncology
Ulla Ramer Mikkelsen, Kasper Dideriksen, Mads Bisgaard Andersen, Anders Boesen, Nikolai Mølkjær Malmgaard-Clausen, Inge Juul Sørensen, Peter Schjerling, Michael Kjær, Lars Holm,
Introduction: Rheumatoid arthritis (RA) is often associated with diminished muscle mass, reflecting an imbalance between protein synthesis and protein breakdown.To investigate the anabolic potential of both exercise and nutritional protein intake we investigated the muscle protein synthesis rate and anabolic signaling response in patients with RA compared to healthy controls.Methods: Thirteen RA patients (age range 34-84 years; diagnosed for 1-32 years, median 8 years) were individually matched with ...
Tópico(s): Nutrition and Health in Aging
2015 - BioMed Central | Arthritis Research & Therapy
Jeppe F. Vigh‐Larsen, Niels Ørtenblad, Ole Emil Andersen, Hallur Thorsteinsson, Thea H. Kristiansen, Stine Bilde, Mads S. Mikkelsen, Joachim Nielsen, Magni Mohr, Kristian Overgaard,
Glycogen particles are situated in key areas of the muscle cell in the vicinity of the main energy-consumption sites and may be utilised heterogeneously dependent on the nature of the metabolic demands. The present study aimed to investigate the time course of fibre type-specific utilisation of muscle glycogen in three distinct subcellular fractions (intermyofibrillar, IMF; intramyofibrillar, Intra; and subsarcolemmal, SS) during repeated high-intensity intermittent exercise. Eighteen moderately ...
Tópico(s): Cardiovascular and exercise physiology
2022 - Wiley | The Journal of Physiology
Andreas Frithioff, Kenneth Weiss, Martin Frendø, Pascal Senn, Peter Trier Mikkelsen, Daniel Sieber, Mads Sølvsten Sørensen, David Bue Pedersen, Steven Arild Wuyts Andersen,
3D-printed temporal bone models can potentially provide a cost-effective alternative to cadaver surgery that can be manufactured locally at the training department. The objective of this study was to create a cost-effective 3D-printed model suitable for mastoidectomy training using entry level and commercially available print technologies, enabling individuals, without prior experience on 3D-printing, to manufacture their own models for basic temporal bone training.Expert technical professionals ...
Tópico(s): Facial Nerve Paralysis Treatment and Research
2023 - BioMed Central | 3D Printing in Medicine
Jan Stentoft Arlbjørn, Ole Stegmann Mikkelsen, Mads Bruun Ingstrup,
The concept of coopetition is well-known in a private-sector context, but it is greatly neglected in a public-sector context. In continuation of this, the article sets out to explore and further position coopetition in the public sector. This is achieved through a study of coopetition among seven municipalities located in a Danish business region named the Triangle Region. The article concludes by identifying and describing four public-sector coopetition segments, and by providing a segmentation ...
Tópico(s): Business Strategy and Innovation
2018 - Taylor & Francis | International Journal of Public Administration
Søren Mikkelsen, Jonathan Wolsing-Hansen, Mads Nybo, Christian Ulrik Maegaard, S Jepsen,
Point-of Care analysis is increasingly being applied in the prehospital scene. Arterial blood gas analysis is one of many new initiatives adding to the diagnostic tools of the prehospital physician. In this paper we present a study on the feasibility of the Radiometer ABL-90 in a ground-based Mobile Emergency Care Unit and report on some clinical situations in which the apparatus has proven beneficial.
Tópico(s): Cardiac Arrest and Resuscitation
2015 - BioMed Central | Scandinavian Journal of Trauma Resuscitation and Emergency Medicine
Steven Arild Wuyts Andersen, Lars Konge, Peter Trier Mikkelsen, Per Cayé‐Thomasen, Mads Sølvsten Sørensen,
Objectives/Hypothesis To explore why novices' performance plateau in directed, self-regulated virtual reality (VR) simulation training and how performance can be improved. Study Design Prospective study. Methods Data on the performances of 40 novices who had completed repeated, directed, self-regulated VR simulation training of mastoidectomy were included. Data were analyzed to identify key areas of difficulty as well as the procedures terminated without using all the time allowed. Results Novices ...
Tópico(s): Radiology practices and education
2016 - Wiley | The Laryngoscope
Anders Lindholm Sørensen, Stine Ulrik Mikkelsen, Trine Alma Knudsen, Mads Emil Bjørn, Christen Lykkegaard Andersen, Ole Weis Bjerrum, Nana Brochmann, Dustin Andersen Patel, Lise Mette Rahbek Gjerdrum, Daniel El Fassi, Torben A. Kruse, Thomas Stauffer Larsen, Hans Torben Mourits‐Andersen, Claus Henrik Nielsen, Christina Ellervik, Niels Pallisgaard, Mads Thomassen, Lasse Kjær, Vibe Skov, Hans Carl Hasselbalch,
We report the final 2-year end-of-study results from the first clinical trial investigating combination treatment with ruxolitinib and low-dose pegylated interferon-α2 (PEG-IFNα2). The study included 32 patients with polycythemia vera and 18 with primary or secondary myelofibrosis; 46 patients were previously intolerant of or refractory to PEGIFNα2. The primary outcome was efficacy, based on hematologic parameters, quality of life measurements, and JAK2 V617F allele burden. We used the 2013 European ...
Tópico(s): Eosinophilic Disorders and Syndromes
2019 - Ferrata Storti Foundation | Haematologica
Ole Skouvig Pedersen, Freja Breth Holmgaard, Mads Kristian Duborg Mikkelsen, Christoph Lange, Giovanni Sotgiu, Troels Lillebæk, Åse Bengård Andersen, Christian Wejse, Victor Næstholt Dahl,
Historically, extensively drug-resistant tuberculosis has been notoriously difficult to treat with devasting outcomes. As we are coming to the end of an era where the 2006 extensively drug-resistant tuberculosis definitions and old treatment regimens are being replaced, we aimed to estimate the proportion of extensively drug-resistant tuberculosis patients globally who achieved successful treatment outcomes.
Tópico(s): Diagnosis and treatment of tuberculosis
2023 - Elsevier BV | Journal of Infection
Stine Ulrik Mikkelsen, Lasse Kjær, Vibe Skov, Mads Emil Bjørn, Christen Lykkegaard Andersen, Ole Weis Bjerrum, Nana Brochmann, Daniel El Fassi, Torben A. Kruse, Thomas Stauffer Larsen, Torben Mourits‐Andersen, Claus Henrik Nielsen, Niels Pallisgaard, Mads Thomassen, Hans Carl Hasselbalch,
Abstract Background: The Philadelphia-negative, chronic myeloproliferative neoplasms (MPN) include essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (MF) (PMF). Chronic inflammation and a deregulated immune system are considered important for clonal evolution and disease progression. Ruxolitinib is a potent anti-inflammatory agent and has shown great benefit in MPN patients (pts), reducing spleen size and inflammation-mediated symptoms, thereby improving quality of life ( ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2015 - Elsevier BV | Blood
Vibe Sommer Mikkelsen, Mads Christian Tofte Gregers, Ulrik Stenz Justesen, Jens Schierbeck, Søren Mikkelsen,
Rapid recognition and antibiotic treatment, preferably preceded by blood cultures (BCs), is a mainstay in sepsis therapy. The objective of this investigation was to determine if pre-hospital BCs were feasible and drawn with an acceptably low level of contamination and to investigate whether pre-hospital antibiotics were administered on correct indications.We performed a register-based study in a pre-hospital physician-manned mobile emergency care unit (MECU) operating in a mixed urban/rural area in ...
Tópico(s): Antibiotic Use and Resistance
2021 - Wiley | Acta Anaesthesiologica Scandinavica
F. Scott Kraly, Jeffrey A. Katz, A. Burchard, C. L. Case, Vojtěch Gabriel, Thomas A. Lanz, Mads S. Mikkelsen, Maria Sokół,
A role for endogenous histamine and histamine receptor subtypes in mediating the inhibition of eating induced by intragastric (i.g.) hypertonic NaCl was examined in adult male Sprague-Dawley rats surgically equipped with a chronic gastric catheter. The i.g. infusion of 2 mL 900 or 1,800 mOsm/kg of NaCl inhibited: 1) ingestion of pellets in rats eating after 24-h food deprivation; and 2) ingestion of cookies in rats eating without prior deprivation. The H1 receptor antagonists dexbrompheniramine (DXB; ...
Tópico(s): Asthma and respiratory diseases
1998 - Elsevier BV | Physiology & Behavior
Finn Rasmussen, Dorrit Mikkelsen, Robert J. Hancox, Jess Lambrechtsen, Mads Nybo, Henrik Hansen, Hans Christian Siersted,
Systemic inflammation has been associated with reduced lung function. However, data on the interrelationships between lung function and inflammation are sparse, and it is not clear if low-grade inflammation leads to reduced lung function. Associations between high-sensitive C-reactive protein (CRP) and spirometric lung function were assessed in a population-based cohort of ∼1,000 Danes aged 20 yrs. In males, the average decline in forced expiratory volume in one second (FEV 1 ) in the highest CRP quintile ...
Tópico(s): Cardiovascular and exercise physiology
2008 - European Respiratory Society | European Respiratory Journal
Steven Arild Wuyts Andersen, Peter Trier Mikkelsen, Lars Konge, Per Cayé‐Thomasen, Mads Sølvsten Sørensen,
Objectives/Hypothesis Cognitive load theory states that working memory is limited. This has implications for learning and suggests that reducing cognitive load (CL) could promote learning and skills acquisition. This study aims to explore the effect of repeated practice and simulator‐integrated tutoring on CL in virtual reality (VR) mastoidectomy simulation. Study Design Prospective trial. Methods Forty novice medical students performed 12 repeated virtual mastoidectomy procedures in the Visible Ear ...
Tópico(s): Visual and Cognitive Learning Processes
2015 - Wiley | The Laryngoscope
Steven Arild Wuyts Andersen, Peter Trier Mikkelsen, Lars Konge, Per Cayé‐Thomasen, Mads Sølvsten Sørensen,
The cognitive load (CL) theoretical framework suggests that working memory is limited, which has implications for learning and skills acquisition. Complex learning situations such as surgical skills training can potentially induce a cognitive overload, inhibiting learning. This study aims to compare CL in traditional cadaveric dissection training and virtual reality (VR) simulation training of mastoidectomy.A prospective, crossover study. Participants performed cadaveric dissection before VR simulation ...
Tópico(s): Digital Imaging in Medicine
2015 - Elsevier BV | Journal of surgical education