Bjørn Petersen, Malene Vejby Mortensen, Mads Hansen, Peter Vuust,
This study investigated the effect of a 6-month one-to-one musical ear-training program on the perception of music, speech, and emotional prosody of deaf patients receiving a cochlear implant (CI).Eighteen patients who recently underwent cochlear implantation were assigned to either a musical ear-training group or a control group.The participants in the music group significantly improved in their overall music perception compared with the control group.In particular, their discrimination of timbre, ...
Tópico(s): Noise Effects and Management
2012 - American Psychological Association | Psychomusicology Music Mind and Brain
Malene Vejby Mortensen, Frank Mirz, Albert Gjedde,
The left inferior prefrontal cortex (LIPC) is involved in speech comprehension by people who hear normally. In contrast, functional brain mapping has not revealed incremental activity in this region when users of cochlear implants comprehend speech without silent repetition. Functional brain maps identify significant changes of activity by comparing an active brain state with a presumed baseline condition. It is possible that cochlear implant users recruited alternative neuronal resources to the ...
Tópico(s): Neuroscience and Music Perception
2006 - Elsevier BV | NeuroImage
Bjørn Petersen, Malene Vejby Mortensen, Albert Gjedde, Peter Vuust,
Cochlear implants (CIs) provide impressive speech perception for persons with severe hearing loss, but many CI recipients fail in perceiving speech prosody and music. Successful rehabilitation depends on cortical plasticity in the brain and postoperative measures. The present study evaluates the behavioral and neurologic effects of musical ear training on CI users' speech and music perception. The goal is to find and work out musical methods to improve CI users' auditory capabilities and, in a longer ...
Tópico(s): Noise Effects and Management
2009 - Wiley | Annals of the New York Academy of Sciences
Rikke Søgaard, Barbara Malene Fischer, Jann Mortensen, Torben Riis Rasmussen, Ulrik Lassen,
Abstract Objectives To assess the expected costs and outcomes of alternative strategies for staging of lung cancer to inform a Danish National Health Service perspective about the most cost-effective strategy. Methods A decision tree was specified for patients with a confirmed diagnosis of non–small-cell lung cancer. Six strategies were defined from relevant combinations of mediastinoscopy, endoscopic or endobronchial ultrasound with needle aspiration, and combined positron emission tomography-computed ...
Tópico(s): Lung Cancer Treatments and Mutations
2013 - Elsevier BV | Value in Health
Rikke Søgaard, Barbara Malene Fischer, Jann Mortensen, Liselotte Højgaard, Ulrik Lassen,
Tópico(s): Medical Imaging Techniques and Applications
2011 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Barbara Malene Fischer, Jann Mortensen, Harald S. Hansen, Peter Vilmann, S. S. Larsen, Annika Loft, A. K. Bertelsen, Jesper Ravn, Paul Frost Clementsen, Asbjørn Høegholm, Klaus Richter Larsen, Asger Dirksen, Birgit Guldhammer Skov, Mark Krasnik, Liselotte Højgaard, Ulrik Lassen,
Correct mediastinal staging is a cornerstone in the treatment of patients with non-small cell lung cancer. A large range of methods is available for this purpose, making the process of adequate staging complex. The objective of this study was to describe faults and benefits of positron emission tomography (PET)-CT in multimodality mediastinal staging.A randomised clinical trial was conducted including patients with a verified diagnosis of non-small cell lung cancer, who were considered operable. ...
Tópico(s): Medical Imaging and Pathology Studies
2010 - BMJ | Thorax
Barbara Malene Fischer, Jann Mortensen, Seppo W. Langer, Annika Loft, Anne Kiil Berthelsen, Gedske Daugaard, Ulrik Lassen, Heine H. Hansen,
There is an increasing amount of evidence on the usability of PET in response evaluation of non-small cell lung cancer. However, data on SCLC is scarce and mainly retrospective. This prospective study assesses the use of PET (positron emission tomography) and PET/CT in response evaluation of patients with small cell lung cancer (SCLC). Methods Assignment of early and final response was compared between PET, PET/CT, and CT in 20 patients with SCLC. Final response as assigned by CT (RECIST) served as ...
Tópico(s): Lung Cancer Treatments and Mutations
2006 - Elsevier BV | Lung Cancer
Barbara Malene Fischer, Jann Mortensen,
Since its introduction in 1974, positron emission tomography (PET) has gained widespread use, especially in diagnosis and staging of lung cancer. In this respect, <sup>18</sup>F-fluorodeoxyglucose (FDG) is by far the most used PET tracer exploiting the increased glucose uptake and metabolism in malignant cells. A large number of studies have suggested that addition of FDG-PET to conventional workup can improve diagnosis and staging in patients with non-small cell lung cancer (NSCLC). In meta- ...
Tópico(s): Lung Cancer Treatments and Mutations
2006 - Karger Publishers | Respiration
Barbara Malene Fischer, Jann Mortensen, Seppo W. Langer, Annika Loft, Anne Kiil Berthelsen, Bodil Laub Petersen, Gedske Daugaard, Ulrik Lassen, Hanne Helene Hansen,
Background: Small-cell lung cancer (SCLC) accounts for 15%–20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.Patients and methods: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. ...
Tópico(s): Lung Cancer Treatments and Mutations
2006 - Elsevier BV | Annals of Oncology
Barbara Malene Fischer, Jann Mortensen, Asger Dirksen, Annika Eigtved, L H JGAARD,
The aim of this study was to assess the value of fluorodeoxyglucose positron emission tomography (FDG PET) imaging of small pulmonary nodules incidentally detected by spiral computed tomography (CT) in a high-risk population. Ten patients (five females, five males, aged 54-72 years) were recruited from an ongoing 4-year placebo controlled intervention study of the effect of inhaled steroids in 300 smokers with moderate to severe chronic obstructive pulmonary disease. The participants received yearly ...
Tópico(s): Medical Imaging and Pathology Studies
2003 - Lippincott Williams & Wilkins | Nuclear Medicine Communications
Barbara Malene Fischer, Jann Mortensen, Liselotte Højgaard,
Lung cancer is the cause of 32% of all male cancer deaths and 25% of all female cancer deaths. Because the prognosis depends on early diagnosis and staging, continuous evaluation of the diagnostic tools available is important. The aim of this study was to assess the diagnostic value of dedicated positron emission tomography (PET) and gamma-camera PET in the diagnostic investigation of non-small-cell lung cancer (NSCLC). A systematic literature search was carried out in the MEDLINE and EMBASE databases ...
Tópico(s): Lung Cancer Research Studies
2001 - Elsevier BV | The Lancet Oncology
Malene Vejby Mortensen, Stig Madsen, Albert Gjedde,
Electrical stimulation with a transtympanic electrode on the promontory of the middle ear allows the tasks of gap detection and temporal difference limen (TDL) to be carried out by both normally hearing and deaf subjects. Previous neuroimaging of normally hearing subjects revealed a region in the right posterior temporal lobe that is crucial to duration discrimination. The present study tested the hypothesis that postlingually deaf subjects recruit this area when they make subtle temporal discriminations. ...
Tópico(s): Multisensory perception and integration
2005 - Elsevier BV | Hearing Research
Malene Lyder Mortensen, Marie Juul Ørnstrup, Claus Højbjerg Gravholt,
Despite appropriate oral glucocorticoid replacement therapy, patients with hypocortisolism often suffer from impaired health and frequent hospitalizations. Continuous subcutaneous hydrocortisone infusion (CSHI) has been developed as an attempt to improve the health status of these patients. The objective of this study was to compare the effects of CSHI to conventional oral treatment on hospitalizations, glucocorticoid doses, and subjective health status. Patients. Nine Danish patients (males: 4 and ...
Tópico(s): Sexual Differentiation and Disorders
2023 - Hindawi Publishing Corporation | International Journal of Endocrinology
Omri Weisman, Esben Agerbo, C. Sue Carter, James C. Harris, Niels Uldbjerg, Tine Brink Henriksen, Malene Thygesen, Preben Bo Mortensen, James F. Leckman, Søren Dalsgaard,
The use of synthetic oxytocin (OT) to induce and/or augment labor and delivery is on the rise. Maternal exposure to OT during birth may have adverse effects on the infant's development, including increased risk for autism. Yet, studies that test this biologically plausible association and whether it is modified by sex are limited and show inconsistent findings. To this end, we conducted an epidemiological analysis, including all singleton live births in Denmark between 2000 and 2009 (N = 557,040), with ...
Tópico(s): Maternal Mental Health During Pregnancy and Postpartum
2015 - Elsevier BV | Behavioural Brain Research
Hanne Frederiksen, Alicja Mortensen, Malene Schrøder, Henrik Lauritz Frandsen, Anette Bysted, Pia Knuthsen, Salka E. Rasmussen,
Abstract Epidemiological studies have suggested an association between consumption of red wine and other polyphenolic compounds and prevention of cardiovascular diseases. In the present study, Watanabe heritable hyperlipidemic (WHHL) rabbits were used to investigate the effects of polyphenols in a red grape skin and seed extract (GSE) on the development of atherosclerosis. WHHL rabbits received either semisynthetic diet (casein based) or semisynthetic diet added GSE over a period of 15 wk. Plasma lipids ...
Tópico(s): Phytoestrogen effects and research
2007 - Wiley | Molecular Nutrition & Food Research
Niels Okkels, Jacob Horsager, Miguel A. Labrador‐Espinosa, Pernille L. Kjeldsen, Malene Flensborg Damholdt, Janne Kaergaard Mortensen, Karsten Vestergård, Karoline Knudsen, Katrine B. Andersen, Tatyana D. Fedorova, Casper Skjærbæk, Hanne Gottrup, Allan K. Hansen, Michel J. Grothe, Per Borghammer,
Cholinergic changes play a fundamental role in the natural history of dementia with Lewy bodies and Lewy body disease in general. Despite important achievements in the field of cholinergic research, significant challenges remain. We conducted a study with four main objectives: (i) to examine the integrity of cholinergic terminals in newly diagnosed dementia with Lewy bodies; (ii) to disentangle the cholinergic contribution to dementia by comparing cholinergic changes in Lewy body patients with and ...
Tópico(s): Neuroscience and Neuropharmacology Research
2023 - Oxford University Press | Brain
Malene Kærslund Hansen, Martin Bødtker Mortensen, Kevin Kris Warnakula Olesen, Pernille Gro Thrane, Michael Mæng,
Identifying patients at high residual risk of atherosclerotic cardiovascular disease (ASCVD) despite statin-treatment is of paramount clinical importance. We aim to investigate if non-high-density lipoprotein cholesterol (non-HDL-C) identifies residual risk of ASCVD and death in statin-treated patients with ischemic heart disease and low-density lipoprotein cholesterol (LDL-C) ≤ 1.8 mmol/L.Leveraging Danish regional and national registries, we identified statin-treated patients with ischemic heart disease ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2023 - Elsevier BV | The Lancet Regional Health - Europe
Malene Vejby Mortensen, Stig Madsen, Albert Gjedde,
To test the hypothesis that ability to discriminate small duration differences is positively correlated with activity in the right temporal lobe, we used positron emission tomography in six normally hearing subjects, stimulated via the promontory in a procedure that mimics the auditory nerve stimulation with a cochlear implant. Stimulus consisted of electrical bursts, and tasks included gap detection and temporal difference limen (TDL). TDL is a measure of discriminatory processing of sound duration ...
Tópico(s): Multisensory perception and integration
2005 - Elsevier BV | Hearing Research
Barbara Malene Fischer, Ulrik Lassen, Jann Mortensen, S. S. Larsen, Annika Loft, A. K. Bertelsen, Jesper Ravn, Paul Frost Clementsen, Asbjørn Høgholm, Klaus Richter Larsen, Torben Riis Rasmussen, Susanne Keiding, Asger Dirksen, Oke Gerke, Birgit Guldhammer Skov, Ida Steffensen, Hanne Helene Hansen, Peter Vilmann, Grete Krag Jacobsen, Vibeke Backer, Niels Maltbæk, Jesper Holst Pedersen, H. VERNON MADSEN, Henrik Nielsen, Liselotte Højgaard,
Fast and accurate staging is essential for choosing treatment for non–small-cell lung cancer (NSCLC). The purpose of this randomized study was to evaluate the clinical effect of combined positron-emission tomography and computed tomography (PET–CT) on preoperative staging of NSCLC.
Tópico(s): Medical Imaging Techniques and Applications
2009 - Massachusetts Medical Society | New England Journal of Medicine
Johan Vansteenkiste, Barbara Malene Fischer, Christophe Dooms, Jann Mortensen,
Tópico(s): Lung Cancer Treatments and Mutations
2004 - Elsevier BV | The Lancet Oncology
Malene Kaas Larsen, Helen Schultz, Michael Bau Mortensen, Regner Birkelund,
Patients with curable esophageal cancer or cancer in the esophageal junction face several challenges during the course of their treatment because of the burden of uncertainty in their prognoses and complexity and side effects of the treatment. The aim of this study is to explore patient experiences with illness, treatment, and decision-making in the context of esophageal cancer. A qualitative approach using phenomenological-hermeneutical methodology was used. Data consisted of participant observations ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2020 - SAGE Publishing | Global Qualitative Nursing Research
Elizabeth Rosted, Thora Grothe Thomsen, Marianne Krogsgaard, Henriette Busk, A. Geisler, Stine Thestrup Hansen, Mette Kjerholt, Camilla Bekker Mortensen, Trine Hørmann Thomsen, Malene Beck, Marian Petersen,
In the current study, we aimed to explore the experiences and attitudes among healthcare professionals as they transitioned from their familiar disciplines to respiratory medicine, intensive care or other departments during the first wave of the COVID-19 pandemic.In preparation for the increasing number of patients suspected of having or who would be severely ill from COVID-19, a major reconstruction of the Danish Healthcare System was initiated. The capacity of the healthcare system to respond ...
Tópico(s): COVID-19 and healthcare impacts
2021 - Wiley | Journal of Clinical Nursing
Marie Maegaard, Malene Monka, Kristine Køhler Mortensen, & Andreas Candefors Stæhr (eds.), Standardization as sociolinguistic change: A transversal study of three traditional dialect areas. Abingdon: Routledge, ...
Tópico(s): Linguistic Variation and Morphology
2022 - Cambridge University Press | Language in Society
Alison B. Singer, Igor Burstyn, Malene Thygesen, Preben Bo Mortensen, M. Daniele Fallin, Diana Schendel,
Environmental exposures and immune conditions during pregnancy could influence development of autism spectrum disorder (ASD) in offspring. However, few studies have examined immune-triggering exposures in relation to ASD. We evaluated the association between parental workplace exposures to risk factors for asthma ("asthmagens") and ASD. We conducted a population-based case-control study in the Danish population using register linkage. Our study population consisted of 11,869 ASD cases and 48,046 controls ...
Tópico(s): Child Nutrition and Feeding Issues
2017 - BioMed Central | Environmental Health
Oleguer Plana‐Ripoll, Natalie C. Momen, John J. McGrath, Theresa Wimberley, Isabell Brikell, Diana Schendel, Malene Thygesen, Nanna Weye, Carsten Bøcker Pedersen, Ole Mors, Preben Bo Mortensen, Søren Dalsgaard,
Information on mental disorders over time is critical for documenting changes in population burden, and aiding understanding of potential causal and non-causal factors. The aim of this study was to provide temporal changes in the sex- and age-specific incidence rates (IR) of mental disorders diagnosed in Danish hospitals during five decades and investigate whether such changes may be attributable to changes in administrative reporting practice.This population-based cohort study included all people ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2022 - Wiley | Acta Psychiatrica Scandinavica
Malene Kaas Larsen, Regner Birkelund, Michael Bau Mortensen, Helen Schultz,
Being a relative of patients with oesophageal cancer or cancer in the oesophageal junction is stressful, as the healthcare system often overlooks concerns about the future as well as the roles and needs of relatives. There is a lack of research addressing relatives' experiences, roles and needs for participation in decisions.To explore relatives' experiences before the start of treatment and their subsequent roles and needs for participation in treatment decisions.A qualitative approach based on ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2020 - Wiley | Scandinavian Journal of Caring Sciences
Christiane Fricke, Malene Schrøder, Morten Poulsen, Klaus von Bergmann, Ingmar Wester, Ib Knudsen, Alicja Mortensen, Dieter Lütjohann,
Foods containing plant sterol or stanol esters can be beneficial in lowering LDL-cholesterol concentration, a major risk factor for CVD. The present study examined whether high dietary intake of rapeseed oil (RSO) derived plant sterol and stanol esters is associated with increased levels of these components in brain tissue of homozygous and heterozygous Watanabe rabbits, an animal model for familial hypercholesterolemia. Homozygous animals received either a standard diet, RSO stanol or RSO sterol ...
Tópico(s): Fatty Acid Research and Health
2007 - Cambridge University Press | British Journal Of Nutrition
Barbara Malene Fischer, Minna W.B. Olsen, Carsten D. Ley, Thomas Levin Klausen, Jann Mortensen, Liselotte Højgaard, Paul E.G. Kristjansen,
Tópico(s): Radiopharmaceutical Chemistry and Applications
2006 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Hanne Frederiksen, Salka E. Rasmussen, Malene Schrøder, Anette Bysted, Jette Jakobsen, Henrik Lauritz Frandsen, Gitte Ravn‐Haren, Alicja Mortensen,
Tomatoes are rich in lycopene and other carotenoids which have shown beneficial effects on CVD in epidemiological and intervention studies. In the present study the effect of an extract of lycopene-rich tomatoes, Lyc-O-Mato ® on atherosclerosis was studied in Watanabe Heritable Hyperlipidemic rabbits. The rabbits were fed a control diet, a control diet supplemented with the tomato extract or a control diet supplemented with a mixture of plant oils for 16 weeks. Lycopene was detected only in plasma ...
Tópico(s): Cholesterol and Lipid Metabolism
2007 - Cambridge University Press | British Journal Of Nutrition
Søren Dalsgaard, Erla Thorsteinsson, Betina B. Trabjerg, Jörg Schullehner, Oleguer Plana‐Ripoll, Isabell Brikell, Theresa Wimberley, Malene Thygesen, Kathrine Bang Madsen, Allan Timmerman, Diana Schendel, John J. McGrath, Preben Bo Mortensen, Carsten Bøcker Pedersen,
Knowledge about the epidemiology of mental disorders in children and adolescents is essential for research and planning of health services. Surveys can provide prevalence rates, whereas population-based registers are instrumental to obtain precise estimates of incidence rates and risks.To estimate age- and sex-specific incidence rates and risks of being diagnosed with any mental disorder during childhood and adolescence.This cohort study included all individuals born in Denmark from January 1, 1995, ...
Tópico(s): Adolescent and Pediatric Healthcare
2019 - American Medical Association | JAMA Psychiatry