Carmen Garrido-Giménez, Manel Mendoza, M. Cruz‐Lemini, Laura Galián-Gay, Olga Sánchez-García, Chiara Granato, Victor Rodríguez‐Sureda, José F. Rodríguez‐Palomares, E. Carreras, L. Cabero, Elisa Llurba, Jaume Alijotas‐Reig,
Preeclampsia is caused by placental impairment with increased expression of sFlt-1 (soluble fms-like tyrosine kinase 1) and decreased PlGF (placental growth factor); it has been associated with cardiovascular morbidity and mortality later in life, but the underlying mechanism remains unknown. The aim of this study was to determine whether sFlt-1 and PlGF levels during preeclampsia are associated to long-term cardiovascular risk. We prospectively recruited 43 women with previous preeclampsia and 21 ...
Tópico(s): Gestational Diabetes Research and Management
2020 - Lippincott Williams & Wilkins | Hypertension
Jordi Cruz, Manel Bautista, José Manuel Amigo, Marcel Blanco,
Near Infrared Chemical Imaging (NIR-CI) is demonstrating an increasing interest in pharmaceutical research since it meets the challenging analytical needs of pharmaceutical quality and may serve as a versatile adjunct to conventional NIR spectroscopy in many fields. The direct analysis of samples by using hyperspectral imaging techniques, which provide a NIR spectrum in each pixel of the image, generates a big amount of information from one sample. Focusing the interest in pharmaceutical research, ...
Tópico(s): Water Quality Monitoring and Analysis
2009 - Elsevier BV | Talanta
José Manuel Amigo, Jordi Cruz, Manel Bautista, S. Maspoch, J. Coello, Marcelo Blanco,
Near-infrared spectroscopy chemical imaging (NIR-CI) is a powerful tool for providing a great deal of information on pharmaceutical samples, since the NIR spectrum can be measured for each pixel of the image over a wide range of wavelengths. Joining NIR-CI with chemometric algorithms (e.g., Principal Component Analysis, PCA) and using correlation coefficients, cluster analysis, classical least-square regression (CLS) and multivariate curve resolution-alternating least squares (MCR-ALS) are of increasing ...
Tópico(s): Advanced Chemical Sensor Technologies
2008 - Elsevier BV | TrAC Trends in Analytical Chemistry
Francesc Vallribera Valls, Filippo Landi, Eloy Espín, José Luis Sánchez, Luís Miguel Jiménez, Marc Martí, L.E. Salgado-Cruz, Manel Armengol,
Tópico(s): Genetic factors in colorectal cancer
2014 - Springer Science+Business Media | Surgical Endoscopy
Dong Sun, Jordi Cruz, Manel Alcalà, Roser Romero del Castillo, Silvia Sans, Joan Casals,
Fast and massive characterization of quality attributes in tomatoes is a necessary step toward its improvement; for sensory attributes this process is time-consuming and very expensive, which causes its absence in routine phenotpying. We aimed to assess the feasibility of near infrared (NIR) spectroscopy as a fast and economical tool to predict both the chemical and sensory properties of tomatoes. We built partial least squares models from spectra recorded from tomato puree and juice in 53 genetically ...
Tópico(s): Listeria monocytogenes in Food Safety
2021 - SAGE Publishing | Journal of Near Infrared Spectroscopy
Tomás Pascual, Patricia Villagrasa, María Vidal, Sergi Ganau, Begoña Bermejo, Ana Julve, Esther Zamora, Ignacio Miranda, Estela Vega, Cristina Márquez, Mafalda Oliveira, Juan Miguel Cejalvo, Luis de la Cruz‐Merino, Manel Juan, Jordi Canes, Xavier González, Aleix Prat,
... Mafalda Oliveira, Juan Miguel Cejalvo, Luis de la Cruz, Manel Juan, Jordi Canes, Xavier Gonzalez, Aleix Prat. SOLTI- ...
Tópico(s): Cancer Genomics and Diagnostics
2020 - American Association for Cancer Research | Cancer Research
Alicia Rubio, José V. Sánchez‐Mut, Esther García, Zahady D. Velásquez, Jorge Oliver‐De La Cruz, Manel Esteller, Jesús Ávila,
Abstract β Amyloid, present in senile plaques, has been related largely to neuronal loss in the brain of patients with Alzheimer's disease. However, how neurons respond to β amyloid insults is still poorly understood. Here we show that β amyloid increases somatostatin and cortistatin gene expression mainly through an increase in histone 3 lysine 4 methylation (H3K4me3), a modification associated with transcriptional activation. Somatostatin and cortistatin partially decreased β amyloid toxicity in ...
Tópico(s): Epigenetics and DNA Methylation
2011 - Wiley | Journal of Neuroscience Research
Josep Pages-Rebull, Clara Pérez‐Ràfols, Núria Serrano, Manel del Valle, José Manuel Díaz‐Cruz,
Recent increase in the adulteration of spices and aromatic herbs in food industry constitutes a problem that requires exhaustive quality control. As every spice has a different composition with characteristic biomarkers, chromatographic profiles are especially valuable to authenticate these products. Thus, in this work a new high performance liquid chromatography (HPLC) method with UV–vis detection was developed for the characterization, identification and authentication of cinnamon, oregano, thyme, ...
Tópico(s): Advanced Chemical Sensor Technologies
2023 - Elsevier BV | Food Bioscience
Antoni Castells, Pere Puig, Josefina Móra, Jaume Boadas, Loreto Boix, Eulàlia Urgell, Manel Solé, Gabriel Capellá, Fèlix Lluı́s, Laureano Fernández‐Cruz, Salvador Navarro, Antoni Farré,
PURPOSE: Previous studies have demonstrated the presence of K-ras mutations in the plasma of patients with pancreatic carcinoma. However, the diagnostic utility and the prognostic significance of this finding have never been addressed. PATIENTS AND METHODS: Forty-four consecutive patients with histologically confirmed primary pancreatic ductal adenocarcinoma were included. A control group of 37 patients with chronic pancreatitis, 10 patients with other tumors of the pancreatic area, nine patients ...
Tópico(s): Cancer Genomics and Diagnostics
1999 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Mariali Palacios-Cruz, Edgar Santos, Manel Cervantes, Moisés León‐Juárez,
A new coronavirus outbreak emerged on the 31st of December 2019 in Wuhan, China, causing commotion among the medical community and the rest of the world. This new species of coronavirus has been termed 2019-nCoV and has caused a considerable number of cases of infection and deaths in China and, to a growing degree, beyond China, becoming a worldwide public health emergency. 2019-nCoV has high homology to other pathogenic coronaviruses, such as those originating from bat-related zoonosis (SARS-CoV), ...
Tópico(s): COVID-19 epidemiological studies
2020 - Elsevier BV | Revista Clínica Española (English Edition)
Mariali Palacios-Cruz, Edgar Santos, Manel Cervantes, Moisés León‐Juárez,
Un nuevo brote de coronavirus surgió el pasado 31 de diciembre de 2019 en Wuhan, China, causando conmoción entre la comunidad médica y el resto del mundo. Esta nueva especie de coronavirus fue denominada como 2019-nCoV, causante de un gran número de casos y fallecimientos en China y en cantidad creciente fuera de ella, convirtiéndose en una emergencia de salud pública a nivel mundial. 2019-nCoV es un virus con alta homología con otros coronavirus patogénicos, como los originados por zoonosis con ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2020 - Elsevier BV | Revista Clínica Española
Ivet Jiménez, Clara Pérez‐Ràfols, Núria Serrano, Manel del Valle, José Manuel Díaz‐Cruz,
A voltammetric sensor based on the modification of a screen-printed carbon electrode with reduced graphene oxide (rGO-SPCE) is presented for the cyclic voltammetric determination of capsaicin in a wide range of concentrations. Special attention was given to factors affecting sensitivity and repeatability in order to overcome common reported issues related to the voltammetric determination of capsaicin. Fouling associated to the adsorption of capsaicin was minimized using a simple and effective washing ...
Tópico(s): Electrochemical Analysis and Applications
2023 - Elsevier BV | Microchemical Journal
Tomás Pascual, Juan Miguel Cejalvo, Mafalda Oliveira, María Vidal, Estela Vega, Sergi Ganau, Ana Julve, Esther Zamora, Ignacio Miranda, Ana Sofia Delgado, Begoña Bermejo, Luis de la Cruz‐Merino, Manel Juan, Juan M. Ferrero-Cafiero, Jordi Canes, Xavier González, Patricia Villagrasa, Aleix Prat,
New treatment strategies such as immune checkpoint inhibitors and oncolytic viruses are opening new possibilities in cancer therapy. Preliminary results in melanoma and other tumors showed that the combination of talimogene laherparepvec with an anti-PD-1/PD-L1 or anti-CTLA4 has greater efficacy than either therapy alone, without additional safety concerns beyond those expected for each agent. The presence of residual cancer after neoadjuvant chemotherapy in early breast cancer patients is an unmet ...
Tópico(s): Immunotherapy and Immune Responses
2020 - Future Medicine | Future Oncology
Laureano Fernández‐Cruz, Manel Puig‐Domingo, Irene Halperín, G. Sesmilo,
Keywords Pheochromocytoma, pheochromocytoma diagnosis, paraganglioma, pheochromocytoma laparoscopic surgery
Tópico(s): Cancer, Hypoxia, and Metabolism
2004 - SAGE Publishing | Scandinavian Journal of Surgery
Esther Gómez‐Gil, Isabel Esteva, Rocío Carrasco, Mari Cruz Almaraz, Eduardo Pásaro, Manel Salamero, Antonio Guillamón,
Tópico(s): Family Dynamics and Relationships
2010 - Springer Science+Business Media | Archives of Sexual Behavior
Esther Gómez‐Gil, Leire Zubiaurre‐Elorza, Isabel Esteva, Antonio Guillamón, Teresa Godás, Mari Cruz Almaraz, Irene Halperín, Manel Salamero,
The aim of the present study was to evaluate the presence of symptoms of current social distress, anxiety and depression in transsexuals. We investigated a group of 187 transsexual patients attending a gender identity unit; 120 had undergone hormonal sex-reassignment (SR) treatment and 67 had not. We used the Social Anxiety and Distress Scale (SADS) for assessing social anxiety and the Hospital Anxiety and Depression Scale (HADS) for evaluating current depression and anxiety. The mean SADS and HADS ...
Tópico(s): LGBTQ Health, Identity, and Policy
2011 - Elsevier BV | Psychoneuroendocrinology
Javier Escaned, Carlos Collet, Nicola Ryan, Giovanni Luigi De Maria, Simon Walsh, Manel Sabaté, Justin E. Davies, Maciej Lesiak, Raúl Moreno, Ignacio Cruz‐González, Stephan P Hoole, Nick E.J. West, Jan J. Piek, Azfar Zaman, Farzin Fath‐Ordoubadi, Rod Stables, Clare Appleby, Nicolas M. Van Mieghem, Robert J. Van Geuns, Neal Uren, Javier Zueco, Paweł Buszman, Andrés Íñiguez, Javier Goicolea, David Hildick‐Smith, Andrzej Ochała, Dariusz Dudek, Colm G. Hanratty, Rafael Cavalcante, A. Pieter Kappetein, David P. Taggart, Gerrit‐Anne van Es, Marie‐Angèle Morel, Ton de Vries, Yoshinobu Onuma, Vasim Farooq, Patrick W. Serruys, Adrian Banning,
To investigate if recent technical and procedural developments in percutaneous coronary intervention (PCI) significantly influence outcomes in appropriately selected patients with three-vessel (3VD) coronary artery disease.The SYNTAX II study is a multicenter, all-comers, open-label, single arm study that investigated the impact of a contemporary PCI strategy on clinical outcomes in patients with 3VD in 22 centres from four European countries. The SYNTAX-II strategy includes: heart team decision-making ...
Tópico(s): Acute Myocardial Infarction Research
2017 - Oxford University Press | European Heart Journal
Yuki Katagiri, Giovanni Luigi De Maria, Norihiro Kogame, Ply Chichareon, Kuniaki Takahashi, Chun Chin Chang, Rodrigo Modolo, Simon Walsh, Manel Sabaté, Justin E. Davies, Maciej Lesiak, Raúl Moreno, Ignacio Cruz‐González, Nick E.J. West, Jan J. Piek, Joanna J. Wykrzykowska, Vasim Farooq, Javier Escaned, Adrian Banning, Yoshinobu Onuma, Patrick W. Serruys,
Abstract Objectives To investigate the impact of minimal stent area (MSA) evaluated by post‐procedural intravascular ultrasound (IVUS) on clinical outcomes after contemporary PCI in patients with three‐vessel disease (TVD). Background The impact of post‐procedural MSA on clinical outcomes has not yet been extensively studied in patients with TVD. Methods The SYNTAX II study is a multicenter, all‐comers, open‐label, single arm study that investigated the impact of a state‐of‐the‐art PCI strategy on ...
Tópico(s): Cardiac Imaging and Diagnostics
2019 - Wiley | Catheterization and Cardiovascular Interventions
Adrian Banning, Patrick W. Serruys, Giovanni Luigi De Maria, Nicola Ryan, Simon Walsh, Nieves Gonzalo, Robert‐Jan van Geuns, Yoshinobu Onuma, Manel Sabaté, Justin E. Davies, Maciej Lesiak, Raúl Moreno, Ignacio Cruz‐González, Stephen P. Hoole, Jan J. Piek, Clare Appleby, Farzin Fath‐Ordoubadi, Azfar Zaman, Nicolas M. Van Mieghem, Neal Uren, Javier Zueco, Paweł Buszman, Andrés Íñiguez, Javier Goicolea, David Hildick‐Smith, Andrzej Ochała, Dariusz Dudek, Ton de Vries, David P. Taggart, Vasim Farooq, Ernest Spitzer, Jan G.P. Tijssen, Javier Escaned,
Abstract Aims The SYNTAX II study evaluated the impact of advances in percutaneous coronary intervention (PCI), integrated into a single revascularization strategy, on outcomes of patients with de novo three-vessel disease. The study employed decision-making utilizing the SYNTAX score II, use of coronary physiology, thin-strut biodegradable polymer drug-eluting stents, intravascular ultrasound, enhanced treatments of chronic total occlusions, and optimized medical therapy. Patients treated with this ...
Tópico(s): Acute Myocardial Infarction Research
2021 - Oxford University Press | European Heart Journal
José Luis Rojo‐Álvarez, Manel Martínez‐Ramón, Jordi Muñoz-Marı́, Gustau Camps‐Valls, Carlos M. Cruz, Anı́bal R. Figueiras-Vidal,
Sparse deconvolution is a classical subject in digital signal processing, having many practical applications. Support vector machine (SVM) algorithms show a series of characteristics, such as sparse solutions and implicit regularization, which make them attractive for solving sparse deconvolution problems. Here, a sparse deconvolution algorithm based on the SVM framework for signal processing is presented and analyzed, including comparative evaluations of its performance from the points of view of ...
Tópico(s): Fault Detection and Control Systems
2008 - Springer Science+Business Media | EURASIP Journal on Advances in Signal Processing
Sílvia Pellitero, Eva Martínez, Rocío Puig, Alba Leis, Roxanna Zavala, María Luisa Granada, Cruz Pastor, Pau Moreno, Jordi Tarascó, Manel Puig‐Domingo,
Tópico(s): Intestinal and Peritoneal Adhesions
2017 - Springer Science+Business Media | Obesity Surgery
Daniel Benítez‐Ribas, Raquel Cabezón, Georgina Flórez‐Grau, Mari Carmen Molero, Patricia Puerta, Antonio Guillén, Azucena González-Navarro, Sonia Paco, Ángel M. Carcaboso, Vicente Santa‐María López, Ofelia Cruz, Carmen de Torres, Noelia Salvador, Manel Juan, Jaume Mora, Andrés Morales La Madrid,
Background and objective Diffuse intrinsic pontine glioma (DIPG) is a lethal brainstem tumor in children. Dendritic cells (DCs) have T-cell stimulatory capacity and, therefore, potential antitumor activity for disease control. DCs vaccines have been shown to reactivate tumor-specific T cells in both clinical and pre-clinical settings. We designed a phase Ib immunotherapy (IT) clinical trial with the use of autologous dendritic cells (ADCs) pulsed with an allogeneic tumors cell-lines lysate (ATCL) in ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2018 - Frontiers Media | Frontiers in Oncology
Tomás Pascual, Juan Miguel Cejalvo, Mafalda Oliveira, María Vidal, Estela Vega, Sergi Ganau, Ana Julve, Esther Zamora, Ignacio Miranda, Ana Sofia Delgado, Begoña Bermejo, Luis de la Cruz‐Merino, Manel Juan, Juan M. Ferrero-Cafiero, Jordi Canes, Xavier González, Patricia Villagrasa, Aleix Prat,
... Miranda, Ana Delgado, Begoña Bermejo, Luis de la Cruz-Merino, Manel Juan, Juan M Ferrero-Cafiero, Jordi Canes, Xavier ...
Tópico(s): HER2/EGFR in Cancer Research
2021 - American Association for Cancer Research | Cancer Research
José Luis Rojo‐Álvarez, Carlos Figuera, Carlos Eugenio Martínez-Cruz, Gustau Camps‐Valls, Felipe Alonso‐Atienza, Manel Martínez‐Ramón,
The problem of signal interpolation has been intensively studied in the information theory literature, in conditions such as unlimited band, nonuniform sampling, and presence of noise. During the last decade, support vector machines (SVM) have been widely used for approximation problems, including function and signal interpolation. However, the signal structure has not always been taken into account in SVM interpolation. We propose the statement of two novel SVM algorithms for signal interpolation, ...
Tópico(s): Ultrasonics and Acoustic Wave Propagation
2007 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Signal Processing
Eva Cases, Luis Natera, Carlos Antón, Paolo Consigliere, Josep Antón Guillén, Enric Cruz, Manel Garrucho,
Tópico(s): Osteoarthritis Treatment and Mechanisms
2020 - Springer Science+Business Media | European Journal of Orthopaedic Surgery & Traumatology
Vicenç Falcó, Queralt Jordano, María Jesús Cruz, Óscar Len, Esteban Ribera, Magda Campins, Manel Crespo, I Ocaña, María José Rodrigo, Albert Pahissa,
The aim of this study was to evaluate specific IgG responses against pneumococcal serotypes 1, 6B, 14, 19F, 23F at baseline, 1 and 12 months after vaccination with the 23-valent polysaccharide pneumococcal vaccine in 89 HAART-treated HIV-infected patients, 24 antiretroviral "naïve" HIV-infected and 30 non-HIV-infected healthy subjects. Levels of specific antipneumococcal IgG and the mean fold increase in IgG levels at 1 month as well as the kinetics of antibodies along the 12 months in all groups ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2005 - Elsevier BV | Vaccine
Anna Palou, Jordi Cruz, Marcelo Blanco, Jaume Tomàs, Joaquín de los Ríos, Manel Alcalà,
The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition). In this work, the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained. In addition, ...
Tópico(s): Analytical Chemistry and Chromatography
2011 - Elsevier BV | Journal of Pharmaceutical Analysis
Montserrat Corominas, Tomás Marquès‐Bonet, Miquel A. Arnedo, Mónica Bayés, Jordina Belmonte, Héctor Escrivà, Rosa Fernández, Toni Gabaldón, Teresa Garnatje, Josep Germain, Manel Niell, Ferran Palero, Joan Pons, Pere Puigdomènech, Laura Aguilera, Francisco Câmara, Jèssica Gómez‐Garrido, Fernando Cruz, Ignacio Sánchez-Escudero, Cristian R Altaba, Célia Alves, Enrique Arboleda, María Capa, Laura Triginer, Vicent Arbona, Conxita Àvila, Laura Baldo, Alba Enguídanos, Andrea Prófumo, Owen S Wangesteen, Margarida Barceló-Serra, Laura R. Botigué, Amparo Monfort, Bernat Burriel‐Carranza, Salvador Carranza, Javier del Campo, Gabriel Mochales‐Riaño, Marc Palmada‐Flores, Héctor Candela, Cristian Cañestro, Carlos Carreras, M. Casanella Doménech, Carles Galià‐Camps, Sara Guirao‐Rico, Jesús Lozano-Fernández, Marta Pascual, Cinta Pegueroles, Alejandro Sánchez‐Gracia, Miguel Á. Carretero, Oriol Grau, Romina Garrido, Xavier Grau‐Bové, Antonio Hermoso, Iana Kim, José A. Jurado‐Rivera, Carles Lalueza‐Fox, Jean‐Baptiste Ledoux, Ramiro Logares, Ramón Massana, Francesc Piferrer, Juli Mauri, Francesc Mesquita‐Joanes, Juan S. Monrós, Jaume Pellicer, Josep Peñuelas, Cristina Roquet, Aurora Ruiz‐Herrera, Guifré Torruella, Xavier Turón, Marc Ventura, Vanesa Jiménez Arroyo, Cristian Cuevas-Caballé, Joan Ferrer, Ivo Gut, Marta Gut, Oriane Hidalgo, Guillem Izquierdo-Arànega, Laia Pérez-Sorribes, Emilio Righi, Marta Riutort, Joan Vallès, Julio Rozas, Tyler Alioto, Roderic Guigó,
Abstract The Catalan Initiative for the Earth BioGenome Project (CBP) is an EBP-affiliated project network aimed at sequencing the genome of the >40 000 eukaryotic species estimated to live in the Catalan-speaking territories (Catalan Linguistic Area, CLA). These territories represent a biodiversity hotspot. While covering less than 1% of Europe, they are home to about one fourth of all known European eukaryotic species. These include a high proportion of endemisms, many of which are threatened. ...
Tópico(s): Genetic diversity and population structure
2024 - Oxford University Press | NAR Genomics and Bioinformatics
Anna Palou, Jordi Cruz, Marcelo Blanco, Rafael Larraz, Juana Frontela, C. Bengoechea, Josep M. González, Manel Alcalà,
The use of industrial paraffin depends upon the properties that are strongly influenced by the composition but also affected by the oil content. Because paraffin is a byproduct of lubricant oils in the petrochemical industry, there is inherently a certain amount of oil that is difficult to remove completely. The determination of the oil content in paraffin is described by the ASTM method, which involves the oil extraction with methyl ethyl ketone (MEK) at a very low temperature (−32 °C). However, this ...
Tópico(s): Analytical Chemistry and Chromatography
2014 - American Chemical Society | Energy & Fuels
Produção Nacional
Revisado por pares
Manel Bautista, Jordi Cruz, Marcelo Blanco,
Near infrared chemical imaging (NIR-CI) has recently emerged as an effective technique for extracting spatial information from pharmaceutical products in an expeditious, non-destructive and non-invasive manner. These features have turned it into a useful tool for controlling various steps in drug production processes. Imaging techniques provide a vast amount of both spatial and spectral information that can be acquired in a very short time. Such a huge amount of data requires the use of efficient ...
Tópico(s): Essential Oils and Antimicrobial Activity
2012 - IM Publications Open | Journal of Spectral Imaging