Manuel Alegre, Mark Hallett, C. Warren Olanow, José Á. Obeso,
... in deep brain stimulation: How far is enough?†‡ Manuel Alegre MD, Corresponding Author Manuel Alegre MD malegre@unav.es Clinical Neurophysiology Section, Clínica ... Pamplona, SpainSearch for more papers by this author Manuel Alegre MD, Corresponding Author Manuel Alegre MD malegre@unav.es Clinical Neurophysiology Section, Clínica ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2012 - Wiley | Movement Disorders
I. Crespo-Félez, Ana Castañeda-Sampedro, Diana I. Sánchez, Estela Fernández‐Alegre, Manuel Álvarez‐Rodríguez, Juan Carlos Domínguez Fernández de Tejerina, Jane M. Morrell, Felipe Martínez‐Pastor,
Selecting the optimal sperm population is essential for success with reproductive techniques. Porcicoll (formerly Androcoll-P) is a colloid formulation for selection of high-quality boar spermatozoa by single layer centrifugation (SLC). To date, most studies have been carried out with fresh semen and large volumes. We carried out 2 experiments to test the use of Porcicoll for thawed boar semen in small volumes. In Experiment 1, cryopreserved semen doses were thawed, split in 200-μL aliquots and layered ...
Tópico(s): Reproductive biology and impacts on aquatic species
2017 - Elsevier BV | Animal Reproduction Science
Pedro Bretcha-Boix, José Farré-Alegre, Manuel Sureda, Carlos Dussan, Juan José Perez Ruixo, Antonio Brugarolas Masllorens,
Tópico(s): Intestinal and Peritoneal Adhesions
2010 - Springer Science+Business Media | Clinical & Translational Oncology
Carlos Carreras, Sara Pont, Fulvio Maffucci, Marta Pascual, Anna Barceló, Flegra Bentivegna, Luís Cardona, F. Alegre, Manuel Sanfélix, Gloria L. Gallardo Fernández, Àlex Aguilar,
Tópico(s): Animal Behavior and Reproduction
2006 - Springer Science+Business Media | Marine Biology
J. Alegre, Manuel Laguna, Joaquı́n Pacheco,
We describe a solution procedure for a special case of the periodic vehicle routing problem (PVRP). Operation managers at an auto parts manufacturer in the north of Spain described the optimization problem to the authors. The manufacturer must pick up parts (raw material) from geographically dispersed locations. The parts are picked up periodically at scheduled times. The problem consists of assigning a pickup schedule to each of its supplier's locations and also establishing daily routes in order ...
Tópico(s): Optimization and Packing Problems
2005 - Elsevier BV | European Journal of Operational Research
Ramón García‐Sánz, José Ramón González‐Porras, Jesús María Hernández‐Rivas, Marta Polo-Zarzuela, Anna Sureda, C. Barrenetxea, Luis Palomera, Rocío López, Carlos Grande-García, Adrián Alegre, Manuel Vargas‐Pabón, Olga Gutierrez, José A. Rodríguez, Jesús F. San Miguel,
Tópico(s): Protein Degradation and Inhibitors
2004 - Springer Nature | Leukemia
Fernando Pareja‐Blanco, Julián Alcázar, Pedro Jesús Cornejo-Daza, Juan Sánchez‐Valdepeñas, Carlos Rodríguez-López, Javier Hidalgo‐de Mora, Miguel Sánchez‐Moreno, Beatriz Bachero‐Mena, Luis M. Alegre, Manuel Ortega‐Becerra,
Objective This study aimed to compare the effects of four velocity‐based training (VBT) programs in bench press (BP) between a wide range of velocity loss (VL) thresholds—0% (VL0), 15% (VL15), 25% (VL25), and 50% (VL50)—on strength gains, neuromuscular adaptations, and muscle hypertrophy. Methods Sixty‐four resistance‐trained young men were randomly assigned into four groups (VL0, VL15, VL25, and VL50) that differed in the VL allowed in each set. Subjects followed a VBT program for 8‐weeks using the BP ...
Tópico(s): Muscle activation and electromyography studies
2020 - Wiley | Scandinavian Journal of Medicine and Science in Sports
Félix Alegre, Manuel F. Landecho, Ana Huerta, Nerea Fernández-Ros, Diego Martínez‐Urbistondo, Nicolás Garcı́a, Jorge Quiroga, Juan Felipe Lucena,
Application of illness-severity scores in Intermediate Care Units (ImCU) shows conflicting results. The aim of the study is to design a severity-of-illness score for patients admitted to an ImCU.We performed a retrospective observational study in a single academic medical centre in Pamplona, Spain. Demographics, past medical history, reasons for admission, physiological parameters at admission and during the first 24 hours of ImCU stay, laboratory variables and survival to hospital discharge were ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2015 - Public Library of Science | PLoS ONE
Manuel Alegre, Fernando Alonso‐Frech, María Rodríguez‐Oroz, Jorge Guridi, Ivana Zamarbide, Miguel Valencia, Manuel Manrique, José Á. Obeso, Julio Artieda,
Abstract A voluntary movement is accompanied by a series of changes in neuronal oscillatory activity in the subthalamic nucleus (STN). These changes can be recorded through electrodes implanted for deep brain stimulation to treat Parkinson's disease in the time interval between the surgery and the internalization of the connections to the batteries. Both baseline activity and movement‐related changes are different in the ‘on’ and ‘off’ medication motor states. In the ‘off’ state a low frequency activity ...
Tópico(s): Neuroscience and Neural Engineering
2005 - Wiley | European Journal of Neuroscience
Manuel Alegre, I G Gurtubay, J. Iriarte, E. Ciordia, Manuel Manrique, Julio Artieda,
Several groups have studied brainstem auditory evoked potentials (BAEPs) in non-human primates. However, the nomenclature of the waves elicited and their correspondence with human waves I–V differ among authors. BAEPs were recorded from six anaesthetised young cynomolgus macaques (Macaca fascicularis), using different sound stimuli parameters. A constant pattern of four main waveforms was present in all the animals with stimulus intensities over 60 dB SPL, although up to four smaller waveforms were ...
Tópico(s): Blind Source Separation Techniques
2001 - Elsevier BV | Hearing Research
Javier Abián‐Vicén, Luis M. Alegre, José Manuel Fernández-Rodríguez, Xavier Aguado Jódar,
Background: The ankle is frequently injured in sporting activities, and therefore it is frequently protected with prophylactic ankle taping. This study aimed first, to compare the mechanical fatigue of two types of prophylactic ankle taping after 30 minutes of intense exercise, one made with elastic tape (ET) and the other with inelastic tape (IT), and second, to investigate the subjects’ perception on the tape restriction and comfort. Materials and Methods: Twenty-seven active women (mean age, 20. ...
Tópico(s): Lower Extremity Biomechanics and Pathologies
2009 - SAGE Publishing | Foot & Ankle International
Manuel Alegre, Alberto Labarga, I G Gurtubay, J. Iriarte, Armando Malanda, Julio Artieda,
Non-phase-locked beta oscillatory changes during passive movements were studied in six healthy volunteers, and compared with those observed in a similar group during ballistic movements. Passive movements consisted of brisk wrist extensions done with the help of a pulley system. Changes in the beta band were determined by means of wavelet and Gabor transforms, and compared statistically with a pre-movement period. In this paradigm, a marked beta energy loss (event-related desynchronization, ERD) ...
Tópico(s): Neural dynamics and brain function
2002 - Elsevier BV | Neuroscience Letters
Manuel Alegre, I aki G. Gurtubay, Alberto Labarga, Jorge Iriarte, Armando Malanda, Julio Artieda,
We studied the effect of stimulus predictability on the alpha and beta changes observed in central regions during stimulus-induced movement paradigms. Six young volunteers were instructed to extend briskly their dominant wrist as soon as possible after hearing a 2000 Hz sound. Two sequences of stimuli were presented to each subject, the first rhythmic at 1/6 s and the second with random intervals between 5 and 13s. A time-frequency analysis of nonphase-locked activity in the 7–37 Hz range was performed ...
Tópico(s): Neural dynamics and brain function
2003 - Lippincott Williams & Wilkins | Neuroreport
Jorge Iriarte, Elena Urrestarazu, Miguel Valencia, Manuel Alegre, Armando Malanda, C. Viteri, Julio Artieda,
Summary Independent component analysis (ICA) is a novel technique that calculates independent components from mixed signals. A hypothetical clinical application is to remove artifacts in EEG. The goal of this study was to apply ICA to standard EEG recordings to eliminate well-known artifacts, thus quantifying its efficacy in an objective way. Eighty samples of recordings with spikes and evident artifacts of electrocardiogram (EKG), eye movements, 50-Hz interference, muscle, or electrode artifact were ...
Tópico(s): Neural dynamics and brain function
2003 - Lippincott Williams & Wilkins | Journal of Clinical Neurophysiology
Manuel Alegre, Alberto Labarga, I G Gurtubay, J. Iriarte, Armando Malanda, Julio Artieda,
Tópico(s): Neuroscience and Neural Engineering
2003 - Springer Science+Business Media | Experimental Brain Research
Manuel Alegre, I G Gurtubay, Alberto Labarga, Jorge Iriarte, Armando Malanda, Julio Artieda,
Objective: We studied movement-related electroencephalographic oscillatory changes in the alpha and beta range during a sequence of two movements in 7 healthy volunteers, in order to investigate the relationship between these changes and each component in the sequence. Methods: The sequence consisted of a wrist active extension-passive flexion followed by a first and second finger pincer. A total of 10.5 s sweeps were recorded using the level of surface electromyographic (EMG) activity in wrist extensors ...
Tópico(s): Neuroscience and Neural Engineering
2003 - Elsevier BV | Clinical Neurophysiology
Julio Artieda, Miguel Valencia, Manuel Alegre, O Olaziregi, Elena Urrestarazu, J. Iriarte,
Tópico(s): EEG and Brain-Computer Interfaces
2003 - Elsevier BV | Clinical Neurophysiology
Pablo Villoslada, Gonzalo Arrondo, Jorge Sepulcre, Manuel Alegre, Julio Artieda,
Cognitive dysfunction is very common in multiple sclerosis (MS) and it severely impairs patients' quality of life. Thus, we explored whether memantine might improve cognitive performance in patients with MS.We conducted a pilot trial with memantine (30 mg/day) in patients with MS with cognitive impairment. The trial was designed as a 1-year, randomized, double-blind, crossover study comparing memantine against a placebo in 60 patients with MS and cognitive impairment. Cognitive impairment was defined ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2008 - Lippincott Williams & Wilkins | Neurology
Susana Oquiñena, Mercedes Iñarrairaegui, Juan J. Vila, Félix Alegre, José Manuel Zozaya, Bruno Sangro,
Tópico(s): Cancer Research and Treatments
2008 - Springer Science+Business Media | Digestive Diseases and Sciences
Manuel Alegre, Carla Barbosa, Miguel Valencia, Marta Pérez-Alcázar, Jorge Iriarte, Julio Artieda,
Summary: The amplitude of the auditory amplitude-modulation following responses (AMFR) is variable, depending on the modulation rate. Although 40-Hz responses have higher amplitudes in adults, the AMFR in the 80- to 120-Hz range are less influenced by sleep and more consistent in children. The effect of attention on 40-Hz responses has been addressed in some studies; however, no study to our knowledge has investigated the effect of attention on other stimulation rates. Our aim was to test the effect ...
Tópico(s): Hearing Loss and Rehabilitation
2008 - Lippincott Williams & Wilkins | Journal of Clinical Neurophysiology
Manuel Alegre, I. Alvarez-Gerriko, Miguel Valencia, J. Iriarte, Julio Artieda,
Stimulus-induced movements are accompanied by a definite pattern of oscillatory changes, that include a frontal 15 Hz synchronization, a central peri-movement desynchronization, and a contralateral beta rebound after the movement. Our aim was to study the oscillatory changes related to the forced termination of a single complex motor program (signature) and compare them with those observed after the normal termination of the movement. Fifty-eight reference-free EEG channels were analyzed in 10 healthy ...
Tópico(s): Neuroscience and Neural Engineering
2008 - Elsevier BV | Clinical Neurophysiology
Jorge Iriarte, Elena Urrestarazu, Manuel Alegre, Alfonso Macı́as, Á Mínguez Gómez, Paola Amaro, Julio Artieda, C. Viteri,
Summary Cardiac changes may occasionally occur during vagus nerve stimulation (VNS) used in epileptic patients. As they can be potentially life‐threatening, it is important to detect them, and this is why an intraoperative test is performed during the implantation. Few cases of asystole during this test have been described. Only one patient with late‐onset bradyarrythmia caused by VNS has been reported. This patient had been implanted 2 years and 4 months before the episode. We present another case ...
Tópico(s): EEG and Brain-Computer Interfaces
2008 - Wiley | Epilepsia
Elena Urrestarazu, Jorge Iriarte, Manuel Alegre, Pedro Clavero, María Rodríguez‐Oroz, Jorge Guridi, José Á. Obeso, Julio Artieda,
Abstract The recordings of local field potentials in the subthalamic nucleus in patients with Parkinson's disease (PD), carried out through the stimulators implanted to treat the motor symptoms of the disease, show a prominent basal (“off”) activity in the beta range, which is attenuated after dopaminergic therapy. A recent study described improvement of parkinsonian features during rapid eyes movements (REM) sleep. We describe, for the first time, the changes in activity of the subthlamic nucleus (STN) ...
Tópico(s): Neuroscience and Neuropharmacology Research
2008 - Wiley | Movement Disorders
Jorge Guridi, María Rodríguez‐Oroz, Javier Arbizu, Manuel Alegre, Elena Prieto, Ignacio Landecho, Miguel Manrique, Julio Artieda, José Á. Obeso,
We report a patient with severe orthostatic tremor (OT) unresponsive to pharmacological treatments that was successfully controlled with thalamic (Vim, ventralis intermedius nucleus) deep brain stimulation (DBS) over a 4-year period. Cortical activity associated with the OT revealed by EEG back-averaging and fluoro-deoxi-glucose PET were also suppressed in parallel with tremor arrest. This case suggests that Vim-DBS may be a useful therapeutic approach for patients highly disabled by OT.
Tópico(s): Glycogen Storage Diseases and Myoclonus
2008 - Wiley | Movement Disorders
Jorge Iriarte, Secundino Fernández, Natalia Fernandez-Arrechea, Elena Urrestarazu, Inmaculada Pagola, Manuel Alegre, Julio Artieda,
Tópico(s): Neuroscience of respiration and sleep
2010 - Springer Science+Business Media | Sleep And Breathing
María Rodríguez‐Oroz, Jon López‐Azcárate, David García‐García, Manuel Alegre, Jon B. Toledo, Miguel Valencia, Jorge Guridi, Julio Artieda, José Á. Obeso,
Behavioural abnormalities such as impulse control disorders may develop when patients with Parkinson's disease receive dopaminergic therapy, although they can be controlled by deep brain stimulation of the subthalamic nucleus. We have recorded local field potentials in the subthalamic nucleus of 28 patients with surgically implanted subthalamic electrodes. According to the predominant clinical features of each patient, their Parkinson's disease was associated with impulse control disorders (n = 10), ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2010 - Oxford University Press | Brain
Carmen Unzu, Ana Sampedro, Itsaso Mauleón, Manuel Alegre, Stuart G. Beattie, Rafael Enrı́quez de Salamanca, Jolanda Snapper, Jaap Twisk, Harald Petry, Gloria González‐Aseguinolaza, Julio Artieda, Maria Sol Rodríguez-Peña, Jesús Prìeto, Antonio Fontanellas,
Acute intermittent porphyria (AIP) is characterized by a hereditary deficiency of hepatic porphobilinogen deaminase (PBGD) activity. Clinical features are acute neurovisceral attacks accompanied by overproduction of porphyrin precursors in the liver. Recurrent life-threatening attacks can be cured only by liver transplantation. We developed recombinant adeno-associated virus (rAAV) vectors expressing human PBGD protein driven by a liver-specific promoter to provide sustained protection against induced ...
Tópico(s): Neurological diseases and metabolism
2010 - Elsevier BV | Molecular Therapy
Jon López‐Azcárate, Mikel Tainta, María Rodríguez‐Oroz, Miguel Valencia, R. Reina Gonzalez, Jorge Guridi, Jorge Iriarte, José Á. Obeso, Julio Artieda, Manuel Alegre,
In Parkinson's disease (PD), the oscillatory activity recorded from the basal ganglia shows dopamine-dependent changes. In the “off” parkinsonian motor state, there is prominent activity in the beta band (12–30 Hz) that is mostly attenuated after dopaminergic therapy (“on” medication state). The on state is also characterized by activity in the gamma (60–80 Hz) and high-frequency (300 Hz) bands that is modulated by movement. We recorded local field potentials from a group of 15 PD patients (three females) ...
Tópico(s): Neuroscience and Neural Engineering
2010 - Society for Neuroscience | Journal of Neuroscience
Marta Pérez-Alcázar, María Jesús Nicolás, Miguel Valencia, Manuel Alegre, J. Iriarte, Julio Artieda,
Steady-state potentials are oscillatory responses generated by rhythmic stimulation of a sensory pathway. The frequency of the response, which follows the frequency of stimulation and potentially indicates the preferential working frequency of the auditory neural network, is maximal at a stimulus rate of 40 Hz for auditory stimuli in humans, but may be different in other species. Our aim was to explore the responses to different frequencies in the rat. The stimulus was a tone modulated in amplitude ...
Tópico(s): EEG and Brain-Computer Interfaces
2007 - Elsevier BV | Experimental Neurology
María Jesús Nicolás, Jon López‐Azcárate, Miguel Valencia, Manuel Alegre, Marta Pérez-Alcázar, Jorge Iriarte, Julio Artieda,
Oscillatory activity can be widely recorded in the cortex and basal ganglia. This activity may play a role not only in the physiology of movement, perception and cognition, but also in the pathophysiology of psychiatric and neurological diseases like schizophrenia or Parkinson's disease. Ketamine administration has been shown to cause an increase in gamma activity in cortical and subcortical structures, and an increase in 150 Hz oscillations in the nucleus accumbens in healthy rats, together with ...
Tópico(s): Neural dynamics and brain function
2011 - Public Library of Science | PLoS ONE