Laura Itzel Quintas‐Granados, Hernán Cortés, Manuel González‐Del Carmen, Gerardo Leyva‐Gómez, Lilia Patricia Bustamante-Montes, Miguel Rodríguez-Morales, Edgar Yebrán Villegas-Vázquez, Israel López-Reyes, Sofía Lizeth Alcaráz‐Estrada, Jorge Sandoval-Basilio, Ernesto Soto‐Reyes, Javad Sharifi‐Rad, Gabriela Figueroa‐González, Octavio D. Reyes‐Hernández,
Abstract Background The ESR 1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed cancer in women that is also present in men. Methylation at promoter A of ESR 1 is the worse prognosis in terms of overall survival; thus, the early detection, prognostic, and prediction of therapy involve some methylation biomarkers. Methods Therefore, our study aimed to examine the methylation levels at the ESR 1 gene in samples from Mexican BC patients ...
Tópico(s): Cancer-related gene regulation
2021 - BioMed Central | Cancer Cell International
Gabriela Figueroa‐González, Claudia Vanessa Arellano-Gutiérrez, Hernán Cortés, Gerardo Leyva‐Gómez, Manuel González‐Del Carmen, Lilia Patricia Bustamante-Montes, Miguel Rodríguez-Morales, Israel López-Reyes, Sofía Lizeth Alcaráz‐Estrada, Jorge Sandoval-Basilio, Laura Itzel Quintas‐Granados, Octavio D. Reyes‐Hernández,
Four single-nucleotide polymorphisms (SNPs) in Mexican patients and their association with the development of breast cancer (BC).This work is focused on determining the association of fibroblast growth factor receptor (rs12196489), TOX3 (rs3803662), human telomerase reverse transcriptase (h TERT, rs10069690), and FTO (rs17817449) polymorphisms and BC in a cohort of Mexican women.The study included 56 patients with a confirmed diagnosis of BC and 83 controls. Clinical characteristics were obtained from ...
Tópico(s): Genetic factors in colorectal cancer
2020 - BioMed Central | Journal of Cancer Research and Therapeutics
Claudio Rodriguez Gonzalez, Débora Basílio-Queirós, Anna‐Lena Neehus, Sylvia Merkert, David Tschritter, Sinem Ünal, Jan Hegermann, Matthias Mörgelin, Jacinta Bustamante, Manuel Nietert, Ulrich Martin, Burkhard Tümmler, Antje Munder, Nico Lachmann,
Cystic fibrosis (CF) is a hereditary autosomal recessive disease driven by deleterious variants of the CFTR gene, leading, among other symptoms, to increased lung infection susceptibility. Mucus accumulation in the CF lung is, as of yet, considered as one important factor contributing to its colonization by opportunistic pathogens such as
Tópico(s): Single-cell and spatial transcriptomics
2024 - Frontiers Media | Frontiers in Immunology