Produção Nacional
Revisado por pares
Flávio Leonel Abreu da Silveira, Manuel Ferreira Lima Filho,
A proposta do texto em questão é a de refletir acerca da simbólica do objeto e seus vínculos com a experiência cotidiana dos grupos sociais, imersos em suas paisagens de pertencimento. Portanto, busca situá-lo para além de uma visão reducionista do "objeto museal" desvinculado do vivido. A imaterialidade dos bens culturais emerge, assim, como uma instância das relações dos sujeitos com o mundo social e uma simbólica das coisas que circulam, dispersando sentidos no mundo. Uma antropologia do objeto ...
Tópico(s): Brazilian cultural history and politics
2005 - UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL | Horizontes Antropológicos
Carla M. Sá, Alice A. Ramos, Marisa Frasson de Azevedo, Cristóvão F. Lima, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
Salvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40-50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes' SOD and CAT activities and on Hsp70 expression in lymphocytes were also evaluated. Four weeks sage tea treatment had no effects on plasma ...
Tópico(s): Essential Oils and Antimicrobial Activity
2009 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Cristina P. R. Xavier, Cristóvão F. Lima, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
Epidemiological studies have shown that nutrition is a key factor in modulating sporadic colorectal carcinoma (CRC) risk. Aromatic plants of the genus Salvia (sage) have been attributed many medicinal properties, which include anticancer activity. In the present study, the antiproliferative and proapoptotic effects of water extracts of Salvia fruticosa (SF) and Salvia officinalis (SO) and of their main phenolic compound rosmarinic acid (RA) were evaluated in two human colon carcinoma-derived cell lines, ...
Tópico(s): Plant biochemistry and biosynthesis
2009 - Routledge | Nutrition and Cancer
Marisa Frasson de Azevedo, Çağrı Çamsarı, Carla M. Sá, Cristóvão F. Lima, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
Abstract In the present study, two phytochemicals – ursolic acid (UA) and luteolin‐7‐glucoside (L7G) – were assessed in vivo in healthy rats regarding effects on plasma glucose and lipid profile (total cholesterol, HDL and LDL), as well as liver glycogen content, in view of their importance in the aetiology of diabetes and associated complications. Both UA and L7G significantly decreased plasma glucose concentration. UA also significantly increased liver glycogen levels accompanied by phosphorylation of ...
Tópico(s): Phytochemicals and Antioxidant Activities
2010 - Wiley | Phytotherapy Research
Marisa Frasson de Azevedo, Cristóvão F. Lima, Manuel Fernandes‐Ferreira, M. J. Almeida, Jonathan M. Wilson, Cristina Pereira‐Wilson,
Abstract Scope: Previous results suggested that the effects of Salvia fruticosa tea (SFT) drinking on glucose regulation might be at the intestinal level. Here we aim to characterize the effects of SFT treatment and of its main phenolic constituent – rosmarinic acid (RA) – on the levels and localization of the intestinal Na+/glucose cotransporter‐1 (SGLT1), the facilitative glucose transporter 2 and glucagon‐like peptide‐1 (GLP‐1). Methods and results: Two models of SGLT1 induction in rats were used: through ...
Tópico(s): Diet, Metabolism, and Disease
2011 - Wiley | Molecular Nutrition & Food Research
Cristóvão F. Lima, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
In the present work, the potential hepatoprotective effects of five phenolic compounds against oxidative damages induced by tert-butyl hydroperoxide (t-BHP) were evaluated in HepG2 cells in order to relate in vitro antioxidant activity with cytoprotective effects. t-BHP induced considerable cell damage in HepG2 cells as shown by significant LDH leakage, increased lipid peroxidation, DNA damage as well as decreased levels of reduced glutathione (GSH). All tested phenolic compounds significantly decreased ...
Tópico(s): Phytochemistry and Biological Activities
2006 - Elsevier BV | Life Sciences
Cristóvão F. Lima, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
Tópico(s): Ginger and Zingiberaceae research
2006 - Elsevier BV | Food and Chemical Toxicology
Cristina P. R. Xavier, Cristóvão F. Lima, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
MAP kinase and PI3K/Akt signalling pathways are commonly altered in colorectal carcinoma (CRC) leading to tumor growth due to increased cell proliferation and inhibition of apoptosis. Several species of the genus Hypericum are used in Portugal to prepare herbal teas to which digestive tract effects are attributed. In the present study, the antiproliferative and proapoptotic effects of the water extracts of H. androsaemum (HA) and H. perforatum (HP) were investigated in two human colon carcinoma-derived ...
Tópico(s): Synthesis of Organic Compounds
2012 - Royal Society of Chemistry | Food & Function
Produção Nacional
Revisado por pares
Gabriella de Lima, Nilson Clementino Ferreira, Manuel Eduardo Ferreira,
A determinação da perda superficial dos solos representa uma informação importante no planejamento territorial. O processo de erosão laminar advém de agentes naturais, como a topografia, a chuva e a tipologia de solos, intensificados pela ação antrópica. Na região metropolitana de Goiânia (RMG), tais processos são agravados pela retirada da cobertura vegetal nativa para expansão urbana e implantação de pastagens e culturas agrícolas. A Equação Universal de Perda dos Solos (USLE), aplicada em Sistemas ...
Tópico(s): Environmental and biological studies
2018 - UNIVERSIDADE FEDERAL DE UBERLÂNDIA | Revista Brasileira de Cartografia
Simin Aysel Florescu, Dragos Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Komal Fareed, Aneela Kidwai, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, David Sapsford, Katherine Bongaerts, Peter J Featherstone, Anthony Ng, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Géri, Antoine Vieillard-Baron, Paul D. R. Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C. Vignesh, Nagarajan Ramakrishnan, Augustian James, Evangeline Elvira, Pratheema Ramachandran, Suresh Babu, Rabindrarajan Ebenezer, Sarayu Krishnamoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Simone Piva, Emanuele Focà, Damiano Rizzoni, Gianluca E.M. Boari, Mattia Marchesi, Magdalena Butler, Keri-Anne Cowdrey, Brittany L. Mason, Melissa Woolett, Eamon Duffy, Yan Chen, Hiromi Nakamuro, Caroline O’Connor, Lauren West, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick J. Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Emmet Major, Julie McAuley, Angus Carter, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Marion Campbell, Filipa Santos, Dan Hansen, Dee Mullan, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Manon Bindels, Mirjam Evers, Anton Prinssen, Morgan Matt, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, D. C. Law, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Adrien Auvet, Celine Ravry, Vanessa Creange, Anne-Hélène Boivin, Amélie Barreau, Sophie Vandewoestyne, Pierre-Louis Declercq, Antoine Marchalot, Cécile Saladin, Stéphanie Gelinotte, Jean-Pierre Eraldi, François Bourgerol, Marion Beuzelin, Rigaud Jean-Philippe, Franck Pourcine, Mehran Monchi, Gaël Pradel, Marie-Helene Hausermann, Michel Boudineau, Thi-My-Hue Nguyen-Valat, Christophe Guitton, Rémy Marnai, Marie-Hélène Leroyer, Michaël Landais, Cédric Darreau, Marjorie Saint Martin, Patrice Tirot, Nicolas Chudeau, Aurélie Brasselet, Lev Volkov, Jean-Christophe Callahan, Juliette Meunier, Thomas Douillard, Elliot Le Basnier, Marion Veillard, Dominique Vivier, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeur, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Dominique Bérard, Brian Grondin-Beaudoin, Marc-André Leclair, Olivier Lesur, Michaël Mayette, Yannick Poulin, Hector Quiroz-Martinez, Charles St-Arnaud, Élaine Carbonneau, Brigitte Bolduc, Julie Bélisle, Marie-Pier Bouchard, Line Côté, Joannie Martineau, Alexandra Naisby, Louise Robert-Petit, Marie-Ève Thibault, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, Aslanian Pierre, Sylvain Bélisle, François Martin Carrier, Emmanuel Charbonney, Martin Girard, Jean-Gilles Guimond, Antoine Halwagi, Christophe Kolan, Nicholas Robillard, Dounia Boumahni, Fatna Benettaib, M Cantin, Katherine Coutu-Beaudry, Ali Ghamraoui, F Lamothe, Martine Lebrasseur, Cindy Prié, Maya Salamé, Patrick Archambault, Émilie Côté, Rosalie Beaudoin, Monia Noël-Hunter, Mireille Boutin, Laurie Couture, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre-Yves Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel,
The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.
American Medical Association
Simin Aysel Florescu, Dragos Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Komal Fareed, Aneela Kidwai, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, David Sapsford, Katherine Bongaerts, Peter J Featherstone, Anthony Ng, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Géri, Antoine Vieillard‐Baron, Paul D. R. Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C. Vignesh, Nagarajan Ramakrishnan, Augustian James, Evangeline Elvira, Ramachandran Pratheema, Suresh Babu, Rabindrarajan Ebenezer, Sarayu Krishnamoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Simone Piva, Emanuele Focà, Damiano Rizzoni, Gianluca E.M. Boari, Mattia Marchesi, Magdalena Butler, Keri-Anne Cowdrey, Brittany L. Mason, Melissa Woolett, Eamon Duffy, Yan Chen, Hiromi Nakamuro, Caroline O’Connor, Lauren West, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kathryn Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Emmet Major, Julie McAuley, Angus Carter, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Marion Campbell, Filipa Santos, Dan Hansen, Dee Mullan, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Manon Bindels, Mirjam Evers, Anton Prinssen, Matt Morgan, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, D. C. Law, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Adrien Auvet, Celine Ravry, Vanessa Creange, Anne-Hélène Boivin, Amélie Barreau, Sophie Vandewoestyne, Pierre-Louis Declercq, Antoine Marchalot, Cécile Saladin, Stéphanie Gelinotte, Jean-Pierre Eraldi, François Bourgerol, Marion Beuzelin, Rigaud Jean-Philippe, Franck Pourcine, Mehran Monchi, Gaël Pradel, Marie-Helene Hausermann, Michel Boudineau, Thi-My-Hue Nguyen-Valat, Christophe Guitton, Rémy Marnai, Marie-Hélène Leroyer, Michaël Landais, Cédric Darreau, Marjorie Saint Martin, Patrice Tirot, Nicolas Chudeau, Aurélie Brasselet, Lev Volkov, Jean-Christophe Callahan, Juliette Meunier, Thomas Douillard, Elliot Le Basnier, Marion Veillard, Dominique Vivier, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeur, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Dominique Bérard, Brian Grondin-Beaudoin, Marc-André Leclair, Olivier Lesur, Michaël Mayette, Yannick Poulin, Hector Quiroz-Martinez, Charles St-Arnaud, Élaine Carbonneau, Brigitte Bolduc, Julie Bélisle, Marie-Pier Bouchard, Line Côté, Joannie Martineau, Alexandra Naisby, Louise Robert-Petit, Marie-Ève Thibault, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, Aslanian Pierre, Sylvain Bélisle, François Martin Carrier, Emmanuel Charbonney, Martin Girard, Jean-Gilles Guimond, Antoine Halwagi, Christophe Kolan, Nicholas Robillard, Dounia Boumahni, Fatna Benettaib, M Cantin, Katherine Coutu-Beaudry, Ali Ghamraoui, F Lamothe, Martine Lebrasseur, Cindy Prié, Maya Salamé, Patrick Archambault, Émilie Côté, Rosalie Beaudoin, Monia Noël-Hunter, Mireille Boutin, Laurie Couture, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre-Yves Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel,
Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
American Medical Association
Yaseen M. Arabi, Anthony Gordon, Lennie Derde, Alistair Nichol, Srinivas Murthy, Farah Al Beidh, Djillali Annane, Lolowa Al Swaidan, Abi Beane, Richard Beasley, Lindsay R. Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte Bradbury, Frank M. Brunkhorst, Meredith Buxton, Adrian Buzgau, Allen C. Cheng, Menno D. de Jong, Michelle A. Detry, Eamon Duffy, Lise J Estcourt, Mark Fitzgerald, Rob Fowler, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Alisa M. Higgins, Thomas Hills, Christopher M. Horvat, David T. Huang, Andrew J. King, François Lamontagne, Patrick R. Lawler, Roger Lewis, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Salim Malakouti, Daniel F. McAuley, Anna McGlothlin, Shay McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Susan C. Morpeth, Paul Mouncey, Katrina Orr, Rachael Parke, Rachael Parke, Asad E. Patanwala, Kathy Rowan, Marlene Santos, Christina Saunders, Christopher W. Seymour, Manu Shankar‐Hari, Steven Y. C. Tong, Alexis F. Turgeon, Anne Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Scott Berry, John C. Marshall, Colin McArthur, Derek Angus, Steven A. Webb, Farah Al-Beidh, Derek Angus, Djillali Annane, Yaseen M. Arabi, Abi Beane, Wilma van Bentum-Puijk, Scott Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte Bradbury, Frank Brunkhorst, Meredith Buxton, Allen C. Cheng, Lennie Derde, Lise J Estcourt, Herman Goossens, Anthony Gordon, Cameron Green, Rashan Haniffa, François Lamontagne, Patrick R. Lawler, Edward Litton, John C. Marshall, Colin McArthur, Daniel F. McAuley, Shay McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Paul Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Rachael Parke, Kathy Rowan, Marlene Santos, Christopher W. Seymour, Alexis F. Turgeon, Anne Turner, Frank L. van de Veerdonk, Steve Webb, Ryan Zarychanski, Yaseen M. Arabi, Lewis Campbell, Allen C. Cheng, Lennie Derde, Andrew Forbes, David Gattas, Cameron Green, Stéphane Héritier, Peter Krüger, Edward Litton, Colin McArthur, Shay McGuinness, Alistair Nichol, Rachael Parke, Rachael Parke, Sandra Peake, Jeffrey Presneill, Ian Seppelt, Tony Trapani, Anne Turner, Steve Webb, Paul J. Young, Zahra Bhimani, Brian H. Cuthbertson, Rob Fowler, François Lamontagne, John C. Marshall, Venika Manoharan, Srinivas Murthy, Marlene Santos, Alexis F. Turgeon, Ryan Zarychanski, Diptesh Aryal, Abi Beane, Arjen Dondrop, Cameron Green, Rashan Haniffa, Madiha Hashmi, Issrah Jawad, Deva Jayakumar, John C. Marshall, Colin McArthur, Srinivas Murthy, Timo Tolppa, Vanessa Singh, Steve Webb, Farah Al-Beidh, Derek Angus, Djillali Annane, Wilma van Bentum-Puijk, Scott Berry, Marc J. M. Bonten, Frank Brunkhorst, Maurizio Cecconi, Lennie Derde, Stéphan Ehrmann, Herman Goossens, Anthony Gordon, Colin McArthur, Paul Mouncey, Alistair Nichol, Lorraine Parker, Mathias W. Pletz, Pedro Póvoa, Gernot Rohde, Kathy Rowan, Steve Webb, Brian Alexander, Derek Angus, Kim Basile, Meredith Buxton, Timothy D. Girard, Christopher M. Horvat, David T. Huang, Kelsey Linstrum, Florian Mayr, Bryan J. McVerry, Stephanie K. Montgomery, Christopher W. Seymour, Richard Beasley, Marc J. M. Bonten, Allen C. Cheng, Nick Daneman, Lennie Derde, Robert Fowler, David Gattas, Anthony Gordon, Cameron Green, Peter Krüger, Colin McArthur, Steve McGloughlin, Susan C. Morpeth, Srinivas Murthy, Alistair Nichol, Mathias W. Pletz, David L. Paterson, Gernot Rohde, Steve Webb, Derek Angus, Wilma van Bentum-Puijk, Lennie Derde, Anthony Gordon, Peter Krüger, Edward Litton, John C. Marshall, Colin McArthur, Srinivas Murthy, Alistair Nichol, Balasubramanian Venkatesh, Steve Webb, Derek Angus, Scott Berry, Marc J. M. Bonten, Allen C. Cheng, Lennie Derde, Herman Goossens, Menno D. de Jong, John C. Marshall, Colin McArthur, Srinivas Murthy, Tim Uyeki, Steve Webb, Derek Angus, Yaseen M. Arabi, J. Kenneth Baillie, Richard Beasley, Scott Berry, Marc J. M. Bonten, Allen C. Cheng, Menno D. de Jong, Lennie Derde, Eamon Duffy, Rob Fowler, Herman Goossens, Anthony Gordon, Cameron Green, Thomas Hills, Colin McArthur, Susan C. Morpeth, Srinivas Murthy, Alistair Nichol, Katrina Orr, Rachael Parke, Rachael Parke, Asad E. Patanwala, Kathy Rowan, Steven Y. C. Tong, Tim Uyeki, Frank L. van de Veerdonk, Steve Webb, Derek Angus, Yaseen M. Arabi, J. Kenneth Baillie, Richard Beasley, Scott Berry, Marc J. M. Bonten, Frank Brunkhorst, Allen C. Cheng, Nichola Cooper, Olaf L. Cremer, Menno D. de Jong, Lennie Derde, Eamon Duffy, James Galea, Herman Goossens, Anthony Gordon, Cameron Green, Thomas Hills, Andrew J. King, Helen L. Leavis, John C. Marshall, Florian Mayr, Colin McArthur, Bryan J. McVerry, Susan C. Morpeth, Srinivas Murthy, Mihai G. Netea, Alistair Nichol, Kayode Ogungbenro, Katrina Orr, Rachael Parke, Asad Patawala, Ville Pettilä, Emma Rademaker, Kathy Rowan, Manoj Saxena, Christopher W. Seymour, Steven Tong Wendy Sligl,
To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19). Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). The primary endpoint was an ordinal scale of organ support-free days. Analyses used a Bayesian cumulative logistic model and expressed treatment effects as an adjusted ...
Springer Science+Business Media
Simin Florescu, Delia Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Aneela Kidwai, Sobia Masood, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, János Bélteczki, István Magyar, Ágnes Fazekas, Sándor Kovács, Viktória Szőke, Adrian Donnelly, Martin Kelly, Naoise Smyth, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Geri, Antoine Vieillard-Baron, Paul Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C Vignesh, Bharath TV, N Ramakrishnan, Augustian James, Evangeline Elvira, Devachandran Jayakumar, Ramachandran Pratheema, Suresh Babu, R Ebenezer, S Krishnaoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Eileen Guilder, Magdalena Butler, Keri-Anne Cowdrey, Melissa Robertson, Farisha Ali, Ellie McMahon, Eamon Duffy, Yan Chen, Catherine Simmonds, Rachael McConnochie, Caroline O’Connor, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Manoj Saxena, Margaret Muteithia, Kelsey Dobell‐Brown, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick J. Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Cameron Knott, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Latesh Poojara, Treena Sara, Kiran Nand, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Julia Affleck, Arif Shaikh, Andrew Murray, Mahesh Ramanan, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Ritesh Sanghavi, Deepak Bhonagiri, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Bree McDonald, Natasha Edmunds, Oscar Hoiting, Marco Peters, Els Rengers, Mirjam Evers, Anton Prinssen, Matt Morgan, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Pierre Declerq, Antoine Marchalot, Stéphanie Gélinotte, Eraldi Jean-Pierre, Bourgerol François, Beuzelin Marion, Rigaud Philippe, Franck Pourcine, Mehran Monchi, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeu, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick D’Aragon, Élaine Carbonneau, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, François Martin Carrier, Dounia Boumahni, Fatna Benettaib, Ali Ghamraoui, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel, David Antcliffe, Maie Templeton, Roceld Rojo, Phoebe Coghlan, Joanna Smee, Gareth J. Barker, André Finn, Gabriele Kreb, Uwe Hoff, Carl Hinrichs, Jens Nee, Euan Mackay, Jon Cort, Amanda Whileman, Thomas E. Spencer, Nick Spittle, Sarah Beavis, Anand Padmakumar, Katie Dale, Joanne Hawes, Emma Moakes, Rachel Gascoyne, Kelly Pritchard, Lesley Stevenson, Justin Cooke, Karolina Nemeth-Roszpopa, Basanta Gauli, Sirjana Bastola, Grégoire Müller, Mai-Anh Nay, Toufik Kamel, Dalila Benzekri, Sophie Jacquier, Isabelle Runge, Armelle Mathonnet, François Barbier, Anne Bretagnol, Jay Carter, Kymbalee Van Der Heyden, Jan Mehrtens, Anna Morris, Stacey Morgan, Tara Burke, Emmanuelle Mercier, Delphine Chartier, Charlotte Salmon, Pierre‐François Dequin, Denis Garot, David Bellemare, Ève Cloutier, Rana Daher, Olivier Costerousse, Marie-Claude Boulanger, Émilie Couillard-Chénard, François Lauzier, Charles Francoeur, Bruno François, Alexandra Gay, Fedou Anne-Laure, Mohamed Ramali, Ooi HC, Alison Ghosh, Rawlings Osagie, Malka Arachchige, Melissa D. Hartley, Winston Cheung, Helen Wong, Patrick Seigne, Joe Eustace, Annmarie O’Callaghan, Fionnuala O'Brien,
The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.
American Medical Association
Simin Florescu, Delia Stanciu, Mihaela Zaharia, Alma Kosa, Daniel Codreanu, Aneela Kidwai, Sobia Masood, Callum Kaye, Amanda Coutts, Lynn MacKay, Charlotte Summers, Petra Polgarova, Neda Farahi, Eleonore Fox, Stephen McWilliam, Daniel B. Hawcutt, Laura Rad, Laura O’Malley, Jennifer Whitbread, Dawn Jones, Rachael Dore, Paula Saunderson, Olivia Kelsall, Nicholas Cowley, Laura Wild, Jessica Thrush, Hannah Wood, Karen Austin, János Bélteczki, István Magyar, Ágnes Fazekas, Sándor Kovács, Viktória Szőke, Adrian Donnelly, Martin Kelly, Beverley J. Hunt, Sinéad O’Kane, Declan McClintock, Majella Warnock, Ryan Campbell, Edmund McCallion, Amine Azaiz, Cyril Charron, Mathieu Godement, Guillaume Geri, Antoine Vieillard-Baron, Paul Johnson, Shirley McKenna, Joanne Hanley, Andrew Currie, Barbara Allen, Clare McGoldrick, Moyra McMaster, Ashwin Mani, Meghena Mathew, Revathi Kandeepan, C Vignesh, Bharath TV, N Ramakrishnan, Augustian James, Evangeline Elvira, Devachandran Jayakumar, Pratheema Ramachandran, Suresh Babu, R Ebenezer, S Krishnaoorthy, Lakshmi Ranganathan, Manisha Ganesan, Madhu Shree, Eileen Guilder, Magdalena Butler, Keri-Anne Cowdrey, Melissa Robertson, Farisha Ali, Ellie McMahon, Eamon Duffy, Yan Chen, Catherine Simmonds, Rachael McConnochie, Caroline O’Connor, Khaled El-Khawas, Angus Richardson, Dianne Hill, Robert J. Commons, Hussam Abdelkharim, Rajeev Jha, Michael Kalogirou, Christine Ellis, Srinivas Murthy, Aibhilin O’Connor, Saranya Thurairatnam, Dipak Mukherjee, Agilan Kaliappan, Mark Vertue, Anne Nicholson, Joanne Riches, Gracie Maloney, Lauren Kittridge, Amanda Solesbury, Angelo Ramos, Daniel Collins, Kathy Brickell, Liadain Reid, Michelle Smyth, Patrick Breen, Sandra Spain, Gerard F. Curley, Natalie McEvoy, Pierce Geoghegan, Jennifer Clarke, Jonathan A. Silversides, Peter McGuigan, Kate A. Ward, Aisling O’Neill, Stephanie Finn, Chris Wright, Jackie Green, Érin Collins, Cameron Knott, Julie Smith, Catherine Boschert, Kitty Slieker, Esther Ewalds, Arnate Sanders, Wendy Wittenberg, Heidi Geurts, Brenda Reeve, William Dechert, Barbara Phillips, Laura Oritz-Ruiz de Gordoa, Julia Affleck, Yogesh Apte, Umesh Subbanna, Roland Bartholdy, Thuy Frakking, Jez Pinnell, Matt Robinson, Lisa Gledhill, Tracy Wood, Karuna Keat, Deepak Bhonagiri, Ritesh Sanghavi, Jodie Nema, Megan K. Ford, Harshel G. Parikh, Bronwyn Avard, Mary Nourse, Oscar Hoiting, Marco Peters, Els Rengers, Mirjam Evers, Anton Prinssen, Morgan Matt, Jade Cole, Helen Hill, Michelle Davies, Angharad Williams, Emma Thomas, Rhys Davies, Matt P. Wise, Patrick D. Grimm, Jens Soukup, Richard Wetzold, Madlen Löbel, Lisa Starke, François Lellouche, Patricia Lizotte, Pierre Declerq, Antoine Marchalot, Stéphanie Gélinotte, Eraldi Jean-Pierre, Bourgerol François, Beuzelin Marion, Rigaud Philippe, Franck Pourcine, Mehran Monchi, David Luís, Romain Mercier, Anne Sagnier, Nathalie Verrier, Cecile Caplin, Jack Richecoeu, Danièle Combaux, Shidasp Siami, Christelle Aparicio, Sarah Vautier, Asma Jeblaoui, Delphine Lemaire-Brunel, Frédérick Carbonneau, Julie Leblond, Gaëtan Plantefève, Cécile Leparco, Damien Contou, Muriel Fartoukh, Laura Courtin, Vincent Labbé, Guillaume Voiriot, Sara Salhi, Michaël Chassé, François Martin Carrier, Dounia Boumahni, Fatna Benettaib, Ali Ghamraoui, Arnaud Sement, Alexandre Gachet, Alexis Hanisch, Abdelmagid Haffiane, Anne-Hélène Boivin, Amélie Barreau, Elodie Guerineau, Séverine Poupblanc, Pierre Egreteau, Montaine Lefevre, Simon Bocher, Guillaume Loup, Lenaïg Le Guen, Vanessa Carn, Mélanie Bertel, David Antcliffe, Maie Templeton, Roceld Rojo, Phoebe Coghlan, Joanna Smee, Gareth J. Barker, André Finn, Gabriele Kreß, Uwe Hoff, Carl Hinrichs, Jens Nee, Euan Mackay, Jon Cort, Amanda Whileman, Thomas E. Spencer, Nick Spittle, Sarah Beavis, Anand Padmakumar, Katie Dale, Joanne Hawes, Emma Moakes, Rachel Gascoyne, Kelly Pritchard, Lesley Stevenson, Justin Cooke, Karolina Nemeth-Roszpopa, Basanta Gauli, Sirjana Bastola, Grégoire Müller, Mai-Anh Nay, Toufik Kamel, Dalila Benzekri, Sophie Jacquier, Isabelle Runge, Armelle Mathonnet, François Barbier, Anne Bretagnol, Jay Carter, Kymbalee Van Der Heyden, Jan Mehrtens, Anna Morris, Stacey Morgan, Tara Burke, Emmanuelle Mercier, Delphine Chartier, Charlotte Salmon, Pierre‐François Dequin, Denis Garot, David Bellemare, Ève Cloutier, Rana Daher, Olivier Costerousse, Marie-Claude Boulanger, Émilie Couillard-Chénard, François Francoeur, Bruno François, Alexandra Gay, Fedou Anne-Laure, Mohamed Ramali, Ooi HC, Alison Ghosh, Rawlings Osagie, Malka Arachchige, Melissa D. Hartley, Winston Cheung, Mark Kol, Helen Wong, Asim A. Shah, Atul Wagh, Peter Bamford, Andrew Reid, Kathryn Cawley, Maria Faulkner, Charlotte Pickering, Ashok Raj, Georgios Tsinaslanidis, Reena Khade, Gloria Agha,
Importance The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain. Objective To determine whether antiplatelet therapy improves outcomes for critically ill adults with COVID-19. Design, Setting, and Participants In an ongoing adaptive platform trial (REMAP-CAP) testing multiple interventions within multiple therapeutic domains, 1557 critically ill adult patients with COVID-19 were enrolled between October 30, 2020, and June 23, 2021, from 105 sites in 8 countries and followed ...
American Medical Association
Mariem Hamed, Elisabete Coelho, Rita Bastos, Dmitry V. Evtuguin, Sónia S. Ferreira, Tânia Lima, Manuel Vilanova, Assaâd Sila, Manuel A. Coimbra, Ali Bougatef,
This work studies the extraction and purification of a novel arabinogalactan from pistachio external hull. It was extracted with a simple method from pistachio hull which is considered as unexploited waste. Based on the results of sugar analysis by GC-FID, glycosidic linkage by GC-MS, NMR spectroscopy, and molecular weight by Size Exclusion Chromatography, pistachio hull water soluble polysaccharides (PHWSP) were identified as a type II arabinogalactan (AG), with characteristic terminally linked α- ...
Tópico(s): Phytochemicals and Antioxidant Activities
2021 - Elsevier BV | Food Chemistry
Nuno Rainha, Kamila Kočí, Ana Varela Coelho, Elisabete Lima, José Baptista, Manuel Fernandes‐Ferreira,
LC–UV and LC–MS analysis were used to study the phenolic composition of water extracts of Hypericum undulatum (HU) shoot cultures and wild-growing (WG) plants. Total phenolic content (TPC), determined using the Folin–Ciocalteu assay, and the antioxidant activity measured by two complementary methods were also performed for each sample. Mass spectrometry revealed several phenolics acids with quinic acid moieties, flavonols, mostly quercetin, luteolin and apigenin glycosides, flavan-3-ols (catechin and ...
Tópico(s): Bioactive natural compounds
2012 - Elsevier BV | Phytochemistry
Francisco A.G. Soares Silva, Francisco M. Campos, Manuel Lima Ferreira, Natália Ribeiro, B. Amaral, Tomás Simões, Cristina L.M. Silva,
Abstract BACKGROUND Wine colour is an important quality parameter, being the first sensorial attribute evaluated during wine tasting. The perception of wine colour can be different depending on many factors, including the depth of the sample under observation. The main objectives of the present study were to measure the colour of Port wines using CIE L *, a *, b * parameters at different depths with various instrumental techniques (spectrophotometry and colorimetry), and to compare the obtained results with ...
Tópico(s): Phytochemicals and Antioxidant Activities
2019 - Wiley | Journal of the Science of Food and Agriculture
Produção Nacional
Revisado por pares
Resumo O artigo versa sobre a construção da “Coleção Karajá William Lipkind” composta por 527 (454 localizados) artefatos do acervo do Setor de Etnologia e Etnografia do Museu Nacional, realizada pelo antropólogo estadunidense William Lipkind. Filho de emigrantes judeus-russos, Lipkind chega ao Brasil num período de eminência da Segunda Guerra Mundial, quando permanece por 14 meses, de 1938 a 1939, entre os Karajá do vale do Araguaia. Sua pesquisa é mediada pela diretora do Museu Nacional, Heloísa ...
Tópico(s): Anthropological Studies and Insights
2017 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Mana
Produção Nacional
Revisado por pares
J.A.R.G. Barbosa, Luciano Paulino Silva, Rozeni Chagas Lima Teles, Gisele Ferreira Esteves, Ricardo Bentes Azevedo, Manuel Mateus Ventura, Sônia Maria de Freitas,
The structure of the Bowman-Birk inhibitor from Vigna unguiculata seeds (BTCI) in complex with β-trypsin was solved and refined at 1.55 Å to a crystallographic Rfactor of 0.154 and Rfree of 0.169, and represents the highest resolution for a Bowman-Birk inhibitor structure to date. The BTCI-trypsin interface is stabilized by hydrophobic contacts and hydrogen bonds, involving two waters and a polyethylene glycol molecule. The conformational rigidity of the reactive loop is characteristic of the specificity ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2006 - Elsevier BV | Biophysical Journal
Alice A. Ramos, Cristóvão F. Lima, Maria de Lourdes Pereira, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
In the present study, the chemoprotective effects of quercetin, rutin and ursolic acid on tert-butyl hydroperoxide (t-BHP)-induced DNA damage in a human hepatoma cell line (HepG2) were investigated by the comet assay. To determine whether protection was due to direct chemical interactions alone or to cellular-mediated responses three different types of treatments were used: simultaneous incubation of cells with individual test compounds and the toxicant; pre-treatment with test compound before addition ...
Tópico(s): Phytochemicals and Antioxidant Activities
2008 - Elsevier BV | Toxicology Letters
Bárbara Parente, Henrique Queiroga, E. Teixeira, Renato Sotto‐Mayor, Fernando Barata, A. Sousa, MJ Melo, F João, R. Nêveda, João Cunha, Andresa Guimarães Fernandes, Martínez-Barrera Luis Manuel, T Cardoso, Lucas Lima Ferreira, Fernando Nogueira, J Duarte, E Semedo, U Brito, Francisco Pimentel, Suely Emília de Barros Santos, Filipa Alves da Costa, T Almodôvar, Amanda Souza Araújo,
Resumen pt: O cancro do pulmao e a causa mais comum de cancro no Mundo. A sobrevida global aos 5 anos e de cerca de 15%, sem grandes previsoes de mudanca. Em Portuga...
Tópico(s): Cancer Diagnosis and Treatment
2007 - Elsevier BV | Revista Portuguesa de Pneumologia
Ronaldo Sousa, André Ferreira, Francisco Carvalho, Manuel Lopes‐Lima, Simone Varandas, Amílcar Teixeira,
Abstract Droughts may be responsible for important ecological impacts in freshwater ecosystems, including the death of rare species. This study assessed the mortality of the endangered pearl mussel Margaritifera margaritifera (Linnaeus, 1758) in the Mente, Rabaçal and Tuela rivers (north west of the Iberian Peninsula) during the extreme summer drought of 2017. Mortality occurred as a result of the low river flow, which led to mussel stranding near the banks and consumption (by predation or scavenging) ...
Tópico(s): Soil and Water Nutrient Dynamics
2018 - Wiley | Aquatic Conservation Marine and Freshwater Ecosystems
Ronaldo Sousa, Joana Garrido Nogueira, André Ferreira, Francisco Carvalho, Manuel Lopes‐Lima, Simone Varandas, Amílcar Teixeira,
The freshwater pearl mussel Margaritifera margaritifera is a highly threatened species in Europe. Several mechanisms may be responsible for the decline in distribution and abundance of European pearl mussel populations, but almost no quantitative data exists about the possible negative impacts of invasive alien species (IAS). In this study, we clearly demonstrate that the invasive signal crayfish Pacifastacus leniusculus predates pearl mussels, using a laboratorial experiment followed by in situ ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2019 - Elsevier BV | The Science of The Total Environment
Ronaldo Sousa, André Ferreira, Francisco Carvalho, Manuel Lopes‐Lima, Simone Varandas, Amílcar Teixeira, Belinda Gallardo,
Freshwater mussels are undergoing rapid global declines due to habitat loss and fragmentation, among other factors, but little is known about the effects of small hydropower plants. Here we assessed the impact of small hydropower plants on the abundance and size structure of the imperilled pearl mussel Margaritifera margaritifera. For this, we sampled 66 sites in three Portuguese rivers (Mente, Rabaçal and Tuela) located upstream and downstream of dams and within the reservoirs. Pearl mussels were ...
Tópico(s): Freshwater macroinvertebrate diversity and ecology
2020 - Elsevier BV | The Science of The Total Environment
Produção Nacional
Revisado por pares
Gil Facina, G. Rodrigues de Lima, Manuel de Jesus Simões, Neil Ferreira Novo, Luíz Henrique Gebrim,
Tamoxifen, an anti-estrogenic drug used in the adjuvant treatment of breast cancer, deserves more investigation for the determination of its efficacy as a prophylactic agent against breast cancer in high risk women. Thus, the action of tamoxifen on the human mammary gland was studied by measuring the number of lysosomes in normal mammary epithelium during the administration of tamoxifen.Tamoxifen was administered only during the luteal phase of the menstrual cycle to avoid interference with corpus ...
Tópico(s): Phytoestrogen effects and research
1997 - Elsevier BV | International Journal of Gynecology & Obstetrics
Cristina P. R. Xavier, Cristóvão F. Lima, Ana Preto, Raquel Seruca, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
KRAS and BRAF mutations are frequent in colorectal carcinoma (CRC) and have the potential to activate proliferation and survival through MAPK/ERK and/or PI3K signalling pathways. Because diet is one of the most important determinants of CRC incidence and progression, we studied the effects of the dietary phytochemicals quercetin (Q), luteolin (L) and ursolic acid (UA) on cell proliferation and apoptosis in two human CRC derived cell lines, HCT15 and CO115, harboring KRAS and BRAF activating mutations, ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2009 - Elsevier BV | Cancer Letters
Rita Azevedo, Andreia Peixoto, Cristiana Gaiteiro, Elisabete Fernandes, Manuel Neves, Luís Lima, Lúcio Lara Santos, José Alexandre Ferreira,
... Gaiteiro 1 , Elisabete Fernandes 1,2,4,5 , Manuel Neves 1,2 , Luís Lima 1,4,6 , Lúcio Lara Santos 1,7 and José Alexandre Ferreira 1,2,4,6 1 Experimental Pathology and ...
Tópico(s): Ubiquitin and proteasome pathways
2017 - Impact Journals LLC | Oncotarget
Mariana Hinzmann, Manuel Lopes‐Lima, Iuliu Boboş, Jorge A. Ferreira, Bernardo Domingues, Jorge Machado,
ABSTRACT The freshwater mussel Anodonta cygnea is commonly used as a model organism for biomineralization studies, its peculiar morphofunctional properties also make it an excellent environmental biomonitor. The first detailed on the calcareous concretions from gill and mantle tissue, as well as fluids of the freshwater bivalve A. cygnea , supported by histological, scanning, spectrometry, and spectroscopy analyses. Through these analyses, the morphology, structure, and chemical characterization of ...
Tópico(s): Orthopaedic implants and arthroplasty
2014 - Wiley | Journal of Morphology
Paulo Morais, Bianca Ferreira Gomes, Pedro Luiz Lima dos Santos, Manuel Gomes, Rudolf Gradinger, Martin Schnall, Salar Bozorgi, Thomas Klein, Dominik Fleischhacker, Piotr Warczok, Ahmad Falahati, Ernst Kozeschnik,
Ever-increasing demands of industrial manufacturing regarding mechanical properties require the development of novel alloys designed towards the respective manufacturing process. Here, we consider wire arc additive manufacturing. To this end, Al alloys with additions of Zn, Mg and Cu have been designed considering the requirements of good mechanical properties and limited hot cracking susceptibility. The samples were produced using the cold metal transfer pulse advanced (CMT-PADV) technique, known ...
Tópico(s): Welding Techniques and Residual Stresses
2020 - Multidisciplinary Digital Publishing Institute | Materials
Alice Cunha, João Paulo de Lima Ferreira, Manuel Alves Rodrígues,
Context: Implementation of Computerised Nursing Information Systems (SIE) has generated the need for nurses to develop new skills in providing care, in order...
Tópico(s): Nursing Diagnosis and Documentation
2010 - Health Sciences Research Unit: Nursing (UICISA: E) | Revista de Enfermagem Referência