Duarte F. Gomes, Manuel Lopes, Carlos Vaz de Carvalho,
The global economic crisis makes it necessary to increase business competitiveness. Lean is a manufacturing philosophy that deserves the attention of employers and their employees, since its objectives are to increase productivity, reduce waste, and optimize available resources. The 5S method is a lean tool that can improve productivity by improving the organization of the workplace. A brief survey of the market showed that there are several organizations dedicated to training and sharing this type ...
Tópico(s): Virtual Reality Applications and Impacts
2013 - Institute of Electrical and Electronics Engineers | IEEE Revista Iberoamericana de Tecnologias del Aprendizaje
Produção Nacional
Revisado por pares
Andréa Araújo Brandão, Celso Amodeo, Cristina Alcântara, Eduardo Costa Duarte Barbosa, Fernando Nobre, Fernando Campos Gomes Pinto, José Fernando Vilela-Martin, José Mesquita Bastos, Juan Carlos Yugar‐Toledo, Marco Antônio Mota Gomes, Mário Fritsch Neves, Marcus Vinícius Bolívar Malachias, Manuel de Carvalho Rodrigues, Oswaldo Passarelli, Paulo César Brandão Veiga Jardim, Pedro Cunha, Rui Póvoa, Teresa Fonseca, Vítor Paixão Dias, Weimar Kunz Sebba Barroso, Wille Oigman,
Departamento de Hipertensao Arterial da Sociedade Brasileira de Cardiologia, Rio de Janeiro, RJ - Brazil
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2017 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Ana Gabriela Silva, Caio Fábio Baeta Lopes, Clóvis Gomes de Carvalho Júnior, Ralph Gruppi Thomé, Hélio Batista dos Santos, Rui Manuel Reis, Rosy Iara Maciel de Azambuja Ribeiro,
Despite the standard approaches to treat the highly aggressive and invasive glioblastoma (GBM), it remains incurable. In this sense, cannabinoids highlight as a promising tool, because this tumor overexpresses CB1 and/or CB2 receptors and being, therefore, can be susceptible to cannabinoids treatment. Thus, this work investigated the action of the cannabinoid agonist WIN55-212-2 on GBM cell lines and non-malignant cell lines, in vitro and in vivo. WIN was selectively cytotoxic to GBM cells. These ...
Tópico(s): Cell death mechanisms and regulation
2019 - Elsevier BV | Toxicology in Vitro
João Manuel Fogaça, Lucas Roberto Pereira Gomes, Márcia Souto Couri, Jaime Iván Rodríguez-Fernández, Cláudio José Barros de Carvalho,
Tópico(s): Insect behavior and control techniques
2021 - Q15088586 | Zootaxa
Produção Nacional
Revisado por pares
Manuel Antônio Gordón-Nuñéz, Marianne de Vasconcelos Carvalho, Thaís Gomes Benevenuto, Maria Fernanda Lopes, Leonardo Miguel Madeira Silva, Hébel Cavalcanti Galvão,
Purpose The purpose of this study was to retrospectively analyze the clinical, demographic, and pathologic properties of oral pyogenic granuloma occurring in a Brazilian population. Patients and Methods We retrieved an archival number of 293 cases that were diagnosed as having oral pyogenic granuloma at the Service of Pathological Anatomy, Discipline of Oral Pathology, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil, during a 38-year period, from 1970 to 2008. The ...
Tópico(s): Oral and Maxillofacial Pathology
2010 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Produção Nacional
Revisado por pares
Jeferson Falcão do Amaral, Maria Izabel Gomès Silva, Manuel Rufino de Aquino Neto, Brinell Arcanjo Moura, Alyne Mara Rodrigues de Carvalho, Patrícia Freire de Vasconcelos, José Maria Barbosa‐Filho, Stanley Juan Chavéz Gutierrez, Silvânia Maria Mendes Vasconcelos, Danielle S. Macêdo, Francisca Cléa Florenço de Sousa,
Abstract Dehydrodieugenol, known as bis ‐eugenol, is a eugenol ortho dimer, and both compounds were able to exhibit anti‐inflammatory and antioxidant activities in previous studies. Furthermore, eugenol showed antidepressant‐like effect; however, the biological actions of bis ‐eugenol on experimental models for screening antidepressant activity are still unknown. The present study investigated a possible antidepressant‐like activity of bis ‐eugenol in the forced swimming test ( FST ) and tail suspension ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2012 - Wiley | Fundamental and Clinical Pharmacology
Maria Manuel Pais de Carvalho Martinho Lourenço, Álvaro Azevedo, Isabel Brandão, Pedro S. Gomes,
Tópico(s): Dental Erosion and Treatment
2017 - Springer Nature | Clinical Oral Investigations
Cristóvão F. Lima, Félix Carvalho, Eduarda Fernandes, Maria de Lourdes Bastos, Paula C. Santos-Gomes, Manuel Fernandes‐Ferreira, Cristina Pereira‐Wilson,
For this study the essential oil (EO) of sage (Salvia officinalis L.) was isolated from air-dried vegetative aerial parts of the plants by hydrodistillation and analysed by GC and GC-MS. A total yield of 12.07 mg of EO per g of plant dry mass was obtained and more than 50 compounds identified. The major compounds were cis-thujone (17.4%), alpha-humulene (13.3%), 1,8-cineole (12.7%), E-caryophyllene (8.5%) and borneol (8.3%). The EO fraction of sage tea was also isolated by partition with pentane and the ...
Tópico(s): Hibiscus Plant Research Studies
2004 - Elsevier BV | Toxicology in Vitro
Produção Nacional
Revisado por pares
Glenda Mendieta‐Leiva, Flávio Nunes Ramos, João Pedro Costa Elias, Gerhard Zotz, Margoth Acuña‐Tarazona, Francine Seehaber Alvim, Daniel Elias Ferreira Barbosa, Geicilaine Alves Basílio, Sven P. Batke, Ana María Benavides, Christopher Thomas Blum, Carlos Renato Boelter, Pedro H. S. Brancalion, María Judith Carmona, Luciana P. Carvalho, Edilia de la Rosa‐Manzano, Helena J. R. Einzmann, Manuel Fernández, Samyra Gomes Furtado, André Luís de Gasper, Valeria Guzmán‐Jacob, Peter Hietz, Mariana Victória Irume, Derio Antonio Jiménez‐López, Michael Kessler, Holger Kreft, Thorsten Krömer, Giesta Maria Olmedo Machado, Nayely Martínez‐Meléndez, Pedro Luiz Sanglard Silva Martins, Rodrigo de Macêdo Mello, Alex Mendes, Luiz Menini Neto, Sara Ribeiro Mortara, Camila Nardy, Rodolfo de Paula Oliveira, Ana Clara Alves Pereira, Luis Pillaca, Adriano Costa Quaresma, Calixto Rodríguez Quiel, Edier Soto Medina, Amanda Taylor, Michael S. Vega, Katrin Wagner, Márcio S. Werneck, Florian Werner, Jan Wolf, Charles E. Zartman, Daniel Zuleta, Borja Jiménez‐Alfaro,
Abstract Vascular epiphytes are a diverse and conspicuous component of biodiversity in tropical and subtropical forests. Yet, the patterns and drivers of epiphyte assemblages are poorly studied in comparison with soil‐rooted plants. Current knowledge about diversity patterns of epiphytes mainly stems from local studies or floristic inventories, but this information has not yet been integrated to allow a better understanding of large‐scale distribution patterns. EpIG‐DB, the first database on epiphyte ...
Tópico(s): Lichen and fungal ecology
2020 - Wiley | Journal of Vegetation Science
Produção Nacional
Revisado por pares
João Manuel Fogaça, Lucas Roberto Pereira Gomes, Márcia Souto Couri, Jaime Iván Rodríguez-Fernández, Cláudio José Barros de Carvalho,
Stomopogon Malloch (Diptera, Muscidae) is a Neotropical genus recorded from Argentina, Bolivia, Brazil, Chile and Peru. In this contribution, the genus is revised, and three new species are described, one from Bolivia (Murillo, La Paz), one from Brazil (Palmas, Paraná) and one from Peru (Wayqecha, Cuzco). The descriptions include color images, illustrations and ultrastructural morphology of the terminalia of the adult. We provide an identification key to the species of Stomopogon and an updated map ...
Tópico(s): Diptera species taxonomy and behavior
2021 - Q15088586 | Zootaxa
Produção Nacional
Revisado por pares
Maria Izabel Gomès Silva, Brinell Arcanjo Moura, Manuel Rufino de Aquino Neto, Adriana da Rocha Tomé, Nayrton Flávio Moura Rocha, Alyne Mara Rodrigues de Carvalho, Danielle S. Macêdo, Silvânia Maria Mendes Vasconcelos, Damião Pergentino de Sousa, Glauce Socorro de Barros Viana, Francisca Cléa Florenço de Sousa,
Tópico(s): Ginger and Zingiberaceae research
2009 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Produção Nacional
Revisado por pares
Marcelo José Gomes da Silva, Jorge Luiz Cardoso, Dayane S. Carvalho, L. P. M. Santos, Luís Flávio Gaspar Herculano, Hamilton Ferreira Gomes de Abreu, Juan Manuel Pardal,
The effects of the prior austenite grain sizes in hydrogen embrittlement of Co-containing 18Ni 300 maraging steel were studied employing Slow Strain Rate Testing (SSRT) in 0.6 M NaCl electrolyte under simultaneuos cathodic polarization. The material was susceptible to hydrogen embrittlement in all investigated conditions. In addition, the examination of the fractured surface revealed that the presence of hydrogen in steel promotes the formation of quasi-cleavage regions and hydrogen-induced cracks ...
Tópico(s): Welding Techniques and Residual Stresses
2019 - Elsevier BV | International Journal of Hydrogen Energy
Ana I. Gonçalves, Márcia T. Rodrigues, Pedro P. Carvalho, Manuel Bañobre‐López, Elvira Paz, P. P. Freitas, Manuela E. Gomes,
The application of magnetic nanoparticles (MNPs) in tissue engineering (TE) approaches opens several new research possibilities in this field, enabling a new generation of multifunctional constructs for tissue regeneration. This study describes the development of sophisticated magnetic polymer scaffolds with aligned structural features aimed at applications in tendon tissue engineering (TTE). Tissue engineering magnetic scaffolds are prepared by incorporating iron oxide MNPs into a 3D structure of ...
Tópico(s): Cellular Mechanics and Interactions
2015 - Wiley | Advanced Healthcare Materials
Luís Alves, Miguel Sá, Estrela Ferreira Cruz, Toni Alves, Marcelo de Carvalho Alves, João Fernando Gomes de Oliveira, Manuel Santos, António Miguel Rosado da Cruz,
Textile and clothing is one of the most important industrial sectors, not only due to the significant number of jobs generated, but also because it addresses one of the people’s fundamental needs (clothing). It is, however, a sector with a huge global environmental impact, and also an important negative social impact, especially in developing countries. Sustainability in the textile and clothing value chain is a known issue, concerning both environmental and economic-social facets of sustainability. ...
Tópico(s): Recycling and Waste Management Techniques
2023 - Multidisciplinary Digital Publishing Institute | Sustainability
Fernando De Carvalho Lopes, Patrícia Pinto‐Pinho, Isabel Gaivão, Ana Martins‐Bessa, Zélia Gomes, Osvaldo Moutinho, Maria Manuel Oliveira, Francisco Peixoto, Rosário Pinto‐Leite,
Supraphysiological ROS levels can lead to apoptosis, lipid peroxidation, and DNA and protein damage. This pilot study aimed to investigate the sperm oxidative damage in subfertile men, to describe the relationship between the antioxidant system and ROS. Sixty-four semen samples were categorised according to the evaluated routine parameters (WHO, WHO laboratory manual for the examination and processing of human semen, 2010). Results were cross-referenced with the DNA damage [Comet (n = 53) and TUNEL (n = ...
Tópico(s): Reproductive Biology and Fertility
2021 - Wiley | Andrologia
Produção Nacional
Revisado por pares
Jamil Cade, Gilberto Szarf, Maria Eduarda Menezes de Siqueira, Áurea J. Chaves, Júlio Andrea, Hélio Roque Figueira, Manuel M.R. Gomes, Bárbara Palma Freitas, Juliana Filgueiras Medeiros, Márcio Ricardo dos Santos, Walter Beneduzzi Fiorotto, Augusto Daige, Rosaly Gonçalves, Marcelo José de Carvalho Cantarelli, Cláudia Maria Rodrigues Alves, Leandro Santini Echenique, Fábio Sândoli de Brito, Marco Perin, Daniel Born, Harvey Hecht, Adriano Caixeta,
Aims We sought to present a series of 13 pregnancy-associated spontaneous coronary artery dissection (P-SCAD), their angiographic and multimodal imaging findings, acute phase treatment, and outcomes. Methods and results Between 2005 and 2015, 13 cases of P-SCAD were collected from a database of 11 tertiary hospitals. The mean age was 33.8 ± 3.7 years; most patients had no risk factors for coronary artery disease, and the majority were multiparous. P-SCAD occurred during the puerperium in 12 patients ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2016 - Oxford University Press | European Heart Journal - Cardiovascular Imaging
... Lopes, Thayse Cristina Pereira Bertucci, Luciano Rapagnã, Rafael de Almeida Tubino, Cassiano Monteiro-Neto, Acácio Ribeiro Gomes Tomas, Maria Cristina Tenório, Tânia Lima, Rosa Souza, Jorge Domingo Carrillo-Briceño, Manuel Haimovici, Kita Macario, Carla Carvalho, Orangel Aguilera Socorro, John P. Hart The Path ...
Tópico(s): Archaeological Research and Protection
1988 - University of Chicago Press | Current Anthropology
Produção Nacional
Revisado por pares
Renata Ferreira de Carvalho Leitão, Gerly AC Brito, Reinaldo B. Oriá, Manuel B. Braga Neto, E. A. L. Bellaguarda, Johann V. SILVA, Antoniella S. Gomes, Roberto CP Lima-Júnior, Francisco JWS Siqueira, Rosemeyre Souza Freire, Mariana Lima Vale, Ronaldo A. Ribeiro,
Abstract Background Methotrexate treatment has been associated to intestinal epithelial damage. Studies have suggested an important role of nitric oxide in such injury. The aim of this study was to investigate the role of nitric oxide (NO), specifically iNOS on the pathogenesis of methotrexate (MTX)-induced intestinal mucositis. Methods Intestinal mucositis was carried out by three subcutaneous MTX injections (2.5 mg/kg) in Wistar rats and in inducible nitric oxide synthase knock-out (iNOS -/- ) and wild- ...
Tópico(s): Effects of Radiation Exposure
2011 - BioMed Central | BMC Gastroenterology
Manuel C. Lemos, Leonor Gomes, Margarida Bastos, Valeriano Leite, Edward Limbert, Davide Carvalho, Conceição Bacelar, Mariana P. Monteiro, Fernando Fonseca, Ana Agapito, João Jácome de Castro, Fernando Regateiro, Manuela Carvalheiro,
Summary Objective Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. Design, patients and measurements A multicentric study involving 46 cases of CPHD (17 familial cases belonging to seven kindreds and 29 sporadic cases) selected on the basis of clinical and hormonal evidence of GH ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2006 - Wiley | Clinical Endocrinology
Produção Nacional
Revisado por pares
Tatiana A. Sepúlveda, Diego S. de SOUZA, Lucas Roberto Pereira Gomes, João Manuel Fogaça, Cláudio José Barros de Carvalho,
The Asian neriid fl y genus Telostylus Bigot (Diptera: Neriidae) is revised, including a key and illustrations of its species.Lectotype designations are proposed for four species: Telostylus babiensis de Meijere, T. decemnotatus Hendel, T
Tópico(s): Forensic Entomology and Diptera Studies
2019 - Institute of Entomology | European Journal of Entomology
Produção Nacional
Revisado por pares
Sin Chan Chou, André Lyra, Jorge Luís Gomes, Daniel Andrés Rodríguez, Minella Alves Martins, Nicole Costa Resende, Priscila Tavares, Claudine Pereira Dereczynski, Isabel L. Pilotto, Alessandro Marques Martins, Luís Felipe Alves de Carvalho, José Luiz Lima Onofre, Idalécio Major, Manuel Penhor, Adérito Santana,
Tópico(s): Tropical and Extratropical Cyclones Research
2020 - Springer Science+Business Media | Climate Dynamics
Hélder Dores, Manuel Almeida, Pedro de Araújo Gonçalves, Patrícia Branco, Augusta Gaspar, Henrique Sousa, Ângela Canha Gomes, Maria João Andrade, Maria Salomé Carvalho, Rui Campante Teles, Luís Raposo, Henrique Mesquita Gabriel, Francisco Pereira Machado, Miguel Mendes,
Increased activation of the sympathetic nervous system plays a central role in the pathophysiology of hypertension (HTN). Catheter-based renal denervation (RDN) was recently developed for the treatment of resistant HTN.To assess the safety and efficacy of RDN for blood pressure (BP) reduction at six months in patients with resistant HTN.In this prospective registry of patients with essential resistant HTN who underwent RDN between July 2011 and May 2013, the efficacy of RDN was defined as ≥ 10 mm Hg ...
Tópico(s): Sodium Intake and Health
2014 - Elsevier BV | Revista Portuguesa de Cardiologia
Produção Nacional
Revisado por pares
Victor Manuel Oporto Lopez, Ana Beatriz Alvarez Pérez, Valdir Ambrósio Moisés, Lourdes de Fátima Gonçalves Gomes, Patricia da Silveira Pedreira, Célia C. Silva, Orlando Campos Filho, Antônio Carlos C. Carvalho,
OBJETIVO: Descrever a apresentação clínica cardiológica e a evolução temporal, estimar a incidência de ectasia ânulo-aórtica e de prolapso da valva mitral, e avaliar a tolerância e a efetividade dos betabloqueadores em crianças com síndrome de Marfan. MÉTODOS: Foram submetidas a exame clínico e ecocardiográfico seriado, durante um ano, 21 crianças com síndrome de Marfan. No ecocardiograma foram analisados: presença de prolapso mitral, diâmetro da raiz aórtica, refluxos das valvas mitral e aórtica, ...
Tópico(s): Aortic Disease and Treatment Approaches
2005 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
João Manuel Fogaça, Lucas Roberto Pereira Gomes, Cláudio José Barros de Carvalho,
A new species, Neodexiopsis hirsuta sp. nov. (Diptera, Muscidae), from Palmas, Paraná, Brazil, is described and illustrated here. The proboscis and male terminalia are described using ultrastructural morphology. This new species resembles a member of the Scathophagidae, although the male terminalia have a typical Coenosiini morphology. The maximum-likelihood (ML) and Bayesian Inference (IB) molecular analyses of the cytochrome c oxidase subunit I (COI) sequences for the new species, along with those ...
Tópico(s): Insect behavior and control techniques
2020 - Elsevier BV | Zoologischer Anzeiger
Bárbara Cunha, Tiago Aguiar, Sofia B. Carvalho, Marta M. Silva, Ricardo A. Gomes, Manuel J.T. Carrondo, Patrícia Gomes‐Alves, Cristina Peixoto, Margarida Serra, Paula M. Alves,
To deliver the required cell numbers and doses to therapy, scaling-up production and purification processes (at least to the liter-scale) while maintaining cells' characteristics is compulsory. Therefore, the aim of this work was to prove scalability of an integrated streamlined bioprocess compatible with current good manufacturing practices (cGMP) comprised by cell expansion, harvesting and volume reduction unit operations using human mesenchymal stem cells (hMSC) isolated from bone marrow (BM-MSC) ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2017 - Elsevier BV | Journal of Biotechnology
Produção Nacional
Revisado por pares
Rossana Santiago de Sousa Azulay, Luís Cristóvão Pôrto, Silva Da, Maria da Glória Tavares, Roberta Maria Duailibe Ferreira Reis, Gilvan Cortês Nascimento, Sabrina da Silva Pereira Damianse, Viviane Chaves de Carvalho Rocha, Marcelo Magalhães, Vandílson Pinheiro Rodrigues, Paulo Ricardo Vilas Boas Carvalho, Manuel dos Santos Faria, Marília Brito Gomes,
Abstract This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1 , -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB1*03 and ...
Tópico(s): Digestive system and related health
2021 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Ana Rita Silva, Elizabete Brasil dos Santos, Shelon Cristina Souza Pinto, Osnara María Mongruel Gómes, Irene Pina‐Vaz, Manuel Fontes Carvalho,
The aim of this study was to investigate in vitro the antimicrobial effect and diffusion against E. faecalis of new intracanal medications on the external root surface. The medications tested were a placebo gel (PC); the new formulations with either 3% nitrofurantoin (NIT) or 3% doxycycline hydrochloride (DX) and 2% chlorhexidine (CHX) gel as positive control. The new formulations were tested using the traditional agar diffusion test (ADT) and an adapted agar diffusion method (AADM), where the teeth were ...
Tópico(s): Anesthesia and Pain Management
2014 - Fundação Odontológica de Ribeirão Preto | Brazilian Dental Journal
Produção Nacional
Revisado por pares
Mariana Samôr Lopes, Thayse Bertucci, Luciano Rapagnã, Rafael de Almeida Tubino, Cassiano Monteiro‐Neto, Acácio Ribeiro Gomes Tomás, Maria Cristina Tenório, Tânia Andrade Lima, Rosa Souza, Jorge D. Carrillo-Briceño, Manuel Haimovici, Kita Macário, Carla Carvalho, Orangel Aguilera Socorro,
Brazilian shellmounds are archaeological sites with a high concentration of marine faunal remains. There are more than 2000 sites along the coast of Brazil that range in age from 8,720 to 985 cal BP. Here, we studied the ichthyoarchaeological remains (i.e., cranial/postcranial bones, otoliths, and teeth, among others) at 13 shellmounds on the southern coast of the state of Rio de Janeiro, which are located in coastal landscapes, including a sandy plain with coastal lagoons, rocky islands, islets ...
Tópico(s): Fish biology, ecology, and behavior
2016 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Rossana Santiago de Sousa Azulay, Débora Cristina Ferreira Lago, Glaucia Abreu Silva Santos, Maria da Glória Tavares, Vandílson Pinheiro Rodrigues, Marcelo Magalhães, Roberta Maria Duailibe Ferreira Reis, Nayara Nunes, Ana Gregória Ferreira Pereira de Almeida, Adriana Guimarães Sá, Gilvan Cortês Nascimento, Sabrina S. P. Damianse, Viviane Chaves de Carvalho Rocha, Silva Da, Marília Brito Gomes, Manuel dos Santos Faria,
We aimed to evaluate the Health-related quality of life (HRQoL) of Type 1 diabetes mellitus (T1D) patients in an admixed Brazilian population. This is a cross-sectional study with 152 T1D patients. HRQoL information was obtained from two self-completed questionnaires: Short Form-6 dimensions and EuroQol-5 dimensions with visual analog scale. For inference of global ancestry, the panel of 46 autosomal informational insertion/deletion ancestry markers was used. Demographic and socioeconomic data, presence ...
Tópico(s): Chronic Disease Management Strategies
2022 - Nature Portfolio | Scientific Reports
Grant Mair, Rüdiger von Kummer, Zoë Morris, Anders von Heijne, Nick Bradey, Lesley Cala, André Peeters, Andrew Farrall, Alessandro Adami, Gillian Potter, Geoff Cohen, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Colin Baigent, David Chadwick, Pippa Tyrrell, Gordon Lowe, Martin Dennis, Geoff Cohen, Karen Innes, Heather Goodare, Richard I. Lindley, Graeme J. Hankey, Karl Matz, Michael Brainin, Gord Gubitz, Stephen Phillips, Stefano Ricci, Antonio Araúz, Eivind Berge, Karsten Bruins Slot, Anna Członkowska, Adam Kobayashi, Manuel Correia, Phillippe Lyrer, Stefan T. Engelter, Veronica Murray, Andreas Terént, Bo Norrving, Per Wester, G.S. Venables, Joanna M. Wardlaw, Andrew Farrall, Zoë Morris, Rüdiger von Kummer, Lesley Cala, Anders von Heijne, Alessandro Adami, André Peeters, Gillian Potter, Nick Bradey, Joanna M. Wardlaw, Rüdiger von Kummer, Andrew Farrall, Robin Sellar, Alessandro Adami, Phil White, Andrew M. Demchuk, Matthew Adams, Grant Mair, Bernard Yan, G.S. Venables, C Blank, Helen Bowler, Cara Doyle, Keith Endean, K. Harkness, Edward F. Parker, Marc Randall, Christine Roffe, Naveed Ahmad, Anand Arora, Susan V. Brammer, J Chembala, B. Davies, Sarah J. Ellis, Richard H. Epstein, K. Finney, Chris Jackson, Changez Jadun, Ruth Kinston, Holly Maguire, I Memon, Indira Natarajan, Michael Poulson, R. Sanyal, Sheila Sills, ANNA E. M. VREEBURG, Elizabeth Ward, Peter Sandercock, Rustam Al‐Shahi Salman, Richard Davenport, Martin Dennis, Peter J. Hand, Simon P. Hart, Ingrid Kane, Sarah Keir, Mary Joan MacLeod, L McKinlay, Hazel Milligan, E SANDEMAN, Jennifer Stone, Cathie Sudlow, Peter R. Taylor, Joanna M. Wardlaw, C Warlow, William Whiteley, A. Olufemi Williams, M. Brown, B.S. Athwal, Vanessa Bassan, Neelima Bhupathiraju, John V. Bowler, Charles Davie, David Doig, Renuka Erande, Stephen Gilbert, Lionel Ginsberg, Nan Greenwood, Simone M. Gregoire, Nicola Harding, Nicholas Losseff, Robert Luder, Nathalie Passeron, Richard Perry, Philip Rayson, Robert Simister, Simon Stone, David J. Werring, James Barrett, H Aitken, Sarah Cherian, Ryan L. Davis, Susan Downham, L Godd, V. L. Gott, David José, Victoria Little, David Lowe, L Luxford, Matthew T. McGrory, Paula Owings, N Price, John Richards, Graeme Sangster, Julian Sherlock, Susan Vargese, Ian Wakefield, Pauline Weir, Paul Guyler, T Attygale, Susan M. Chandler, Lucy Coward, S Feasey, C Khuoge, Thayalini Loganathan, Sascha E. Martin, Anne Sibley O'Brien, D Sinha, Vanessa R. Thompson, Sharon Tysoe, Richard Walsh, Kerstin Metcalf, Jeffrey I. Cochius, Ryan P. Fulcher, Nisal Gange, Catherine Green, Jacqui Jagger, M Lee, Phyo Kyaw Myint, John F. Potter, Garth Ravenhill, Stephanie Shields, Naval Shinh, Tom Staunton, Eleanor Thomas, Wendy A. Woodward, P. H. L. WORTH, N. Wyatt, W Sunman, Philip M. Bath, Peter H. Berman, Judith Clarke, Catherine Gaynor, Fiona Hammonds, Rowan Harwood, Kate M. Mitchell, Soumyabrata Munshi, Sarah Pacey, Ashit Shetty, Nikola Sprigg, H Stear, G. Mani Subramanian, Andrew K. Wills, Anthony Rudd, Heinrich J. Audebert, Ajay Bhalla, Jonathan Birns, Rasheda A. Chowdhury, Gillian Cluckie, Ian G. Davies, Charlotte Gibbs, Patrick Holmes, Nicola J. Mitchell, Francesca Schiavone, Eleanor White, Meredith T. Yeung, A. Mehrzad, Vidyagauri P. Baliga, Eli M. Brown, Lewis Burnside, Bernard Esisi, Jennifer L. Kent, Orr P, David Stead, Emma Wayman, R Durairaj, C Cullen, Rohit Kumar, H Martı́n, Dermot T. McDowell, Alka Sharma, Victoria Sutton, Robert M. White, Thomas A. Hughes, Khalid Ali, J. Anderson, Katherine Baker, K Bethune, K Bethune, M Booth, M. Cossburn, Sophie Halpin, M D Hourihan, E. Neil G. Marsh, K. J. Peall, Rebecca Powell, Hamsaraj Shetty, M. Wardle, Michelle A. Williams, K Muhiddin, J. Beavan, M Clarke, R Donneley, Simon Elliott, Peter Fox, Peter H. Gorman, Margaret Harper, M Mangoyana, I Memon, Lisa Mills, L Wright, Liz Warburton, Jean‐Claude Baron, Peter Barry, Diana J. Day, Teresa Harold, Pilar Matía‐Martín, Jennifer Mitchell, Eoin O’Brien, J Rycarte, M Turnham, Geoffrey Cloud, L Y Lois Choy, Ben Clarke, C. J. Griffin, Omid Halse, Ifan Jones, Fiona Kennedy, Uzma Khan, Russell E. Lewis, Alison Loosemore, Caroline Lovelock, Markus Holtmannspötter, B. Moynihan, J. N. O'Reilly, Paul Olowoyo, Anthony Pereira, Martin Punter, Preston B. Rich, Debbie Rolfe, Francesca Schiavone, Martin James, James Bell, A. Bowring, Lucy Boxall, Julie Cageao, H. Eastwood, Salim Elyas, Fiona Hall, S. Harries, Anthony Hemsley,
Objective: To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). Methods: All prerandomization and follow-up (24–48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by masked raters. We assessed whether HAS grew, persisted, shrank, or disappeared at follow-up, the association with 6-month functional outcome, and effect of alteplase. ...
Lippincott Williams & Wilkins