1997 - Gale Group | Chatham House Online Part 2
Mariano Matilla-García, Manuel Ruiz Marín,
... SpainSearch for more papers by this authorManuel Ruiz Marín, Manuel Ruiz Marín Facultad de C.C. de la ... SpainSearch for more papers by this authorManuel Ruiz Marín, Manuel Ruiz Marín Facultad de C.C. de la Empresa, Departamento ...
Tópico(s): Land Use and Ecosystem Services
2011 - Wiley | Geographical Analysis
Marin Manuel, Daniel Zytnicki,
... 6Diversity of Mammalian Motoneurons and Motor UnitsMarcin Bączyk, Marin Manuel, Francesco Roselli and Daniel Zytnicki7 September 2022Ia EPSPs ...
Tópico(s): Ion channel regulation and function
2011 - Imperial College Press | Journal of Integrative Neuroscience
Rafael Alvarez, Ernesto Carmona, José M. Marín, Manuel L. Poveda, Enrique Gutiérrez‐Puebla, Ángeles Monge,
... adducts of molybdenumRafael. Alvarez, Ernesto. Carmona, Jose M. Marin, Manuel L. Poveda, Enrique. Gutierrez-Puebla, and Angeles. MongeCite ...
Tópico(s): Chemistry and Chemical Engineering
1986 - American Chemical Society | Journal of the American Chemical Society
Ernesto Carmona, Luis Sánchez, José M. Marín, Manuel L. Poveda, Jerry L. Atwood, Ralph D. Priester, Robin D. Rogers,
... CO)(PMe3)2Ernesto Carmona, Luis Sanchez, Jose M. Marin, Manuel L. Poveda, Jerry L. Atwood, Ralph D. Priester, ...
Tópico(s): Metalloenzymes and iron-sulfur proteins
1984 - American Chemical Society | Journal of the American Chemical Society
Ernesto Carmona, Karl Döppert, José M. Marín, Manuel L. Poveda, Luis Sánchez, Roberto A. Sánchez‐Delgado,
... tungsten(II)Ernesto Carmona, Karl Doppert, Jose M. Marin, Manuel L. Poveda, Luis Sanchez, and Roberto Sanchez-DelgadoCite ...
Tópico(s): Synthesis and Reactivity of Sulfur-Containing Compounds
1984 - American Chemical Society | Inorganic Chemistry
Ernesto Carmona, José M. Marín, Manuel L. Poveda, Jerry L. Atwood, Robin D. Rogers,
... 2(CO)(PMe3)3]Ernesto Carmona, Jose M. Marin, Manuel L. Poveda, Jerry L. Atwood, and Robin D. ...
Tópico(s): Asymmetric Hydrogenation and Catalysis
1983 - American Chemical Society | Journal of the American Chemical Society
Ana Escrig, Raquel Marín, Manuel Mas,
... BY UPREGULATING CONSTITUTIVE NOS ISOFORMS ANA ESCRIG, RAQUEL MARIN, and MANUEL MAS ANA ESCRIGANA ESCRIG , RAQUEL MARINRAQUEL MARIN , and MANUEL MASMANUEL MAS View All Author Informationhttps://doi.org/ ... ANA ESCRIG More articles by this author RAQUEL MARIN More articles by this author MANUEL MAS More articles by this author Expand All ...
Tópico(s): Urinary Bladder and Prostate Research
1999 - Lippincott Williams & Wilkins | The Journal of Urology
Vicki M. Tysseling, David A. Klein, Rebecca D Imhoff-Manuel, Marin Manuel, C. J. Heckman, Matthew C. Tresch,
After spinal cord injury (SCI), reflexes become hyperexcitable, leading to debilitating muscle spasms and compromised motor function. Previous work has described adaptations in spinal systems that might underlie this hyperexcitability, including an increase in constitutively active 5-HT2C receptors in spinal motoneurons. That work, however, examined adaptations following complete transection SCI, whereas SCI in humans is usually anatomically and functionally incomplete. We therefore evaluated whether ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2017 - American Physiological Society | Journal of Neurophysiology
Manuel Marin A., F. Gary Stiles,
... of the Spot-Fronted Swift Get access Manuel Marín A, Manuel Marín A Western Foundation of Vertebrate Zoology, 439 Calle ...
Tópico(s): Avian ecology and behavior
1993 - Oxford University Press | Ornithological Applications
Manuel Arroyo‐Morales, Nicolás Olea, Marin Manuel Martínez, Amparo Hidalgo-Lozano, Concepción Ruiz-Rodríguez, Lourdes Díaz‐Rodríguez,
Objective: The aim of this study was to evaluate the effect of massage on neuromuscular recruitment, mood state, and mechanical nociceptive threshold (MNT) after high-intensity exercise. Design: This was a prospective randomized clinical trial using between-groups design. Setting: The study was conducted at a university-based sports medicine clinic. Participants: Sixty-two (62) healthy active students age 18–26 participated. Interventions: Participants, randomized into two groups, performed three ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2008 - Mary Ann Liebert, Inc. | The Journal of Alternative and Complementary Medicine
María de Lourdes Martínez-Silva, Rebecca D Imhoff-Manuel, Aarti Sharma, C. J. Heckman, Neil A. Shneider, Francesco Roselli, Daniel Zytnicki, Marin Manuel,
Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a motor unit determines the relative susceptibility of its motoneuron in ALS, then one would expect the most vulnerable motoneurons to display the strongest hyperexcitability prior to their degeneration, whereas the less vulnerable should display a moderate hyperexcitability, if any. We tested this hypothesis in vivo in two unrelated ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2018 - eLife Sciences Publications Ltd | eLife
Marin Manuel, Daniel Zytnicki,
The field of motoneuron and motor unit physiology in mammals has deeply evolved the last decade thanks to the parallel development of mouse genetics and transcriptomic analysis and of in vivo mouse preparations that allow intracellular electrophysiological recordings of motoneurons. We review the efforts made to investigate the electrophysiological properties of the different functional subtypes of mouse motoneurons, to decipher the mosaic of molecular markers specifically expressed in each subtype, ...
Tópico(s): Cardiomyopathy and Myosin Studies
2018 - Elsevier BV | Current Opinion in Physiology
Mehdi Hichor, Venkat Krishnan Sundaram, Stéphanie Eid, Ronza Abdel-Rassoul, Patrice X. Petit, Didier Borderie, Jean Bastin, Assaad A. Eid, Marin Manuel, Julien Grenier, Charbel Massaad,
Reactive oxygen species (ROS) modify proteins and lipids leading to deleterious outcomes. Thus, maintaining their homeostatic levels is vital. This study highlights the endogenous role of LXRs (LXRα and β) in the regulation of oxidative stress in peripheral nerves. We report that the genetic ablation of both LXR isoforms in mice (LXRdKO) provokes significant locomotor defects correlated with enhanced anion superoxide production, lipid oxidization and protein carbonylation in the sciatic nerves despite ...
Tópico(s): Adipose Tissue and Metabolism
2018 - Nature Portfolio | Scientific Reports
Seoan Huh, Ramamurthy Siripuram, Robert H. Lee, Vladimir V. Turkin, Derek O’Neill, Thomas M. Hamm, C. J. Heckman, Marin Manuel,
The majority of studies on the electrical properties of neurons are carried out in rodents, and in particular in mice. However, the minute size of this animal compared with humans potentially limits the relevance of the resulting insights. To be able to extrapolate results obtained in a small animal such as a rodent, one needs to have proper knowledge of the rules governing how electrical properties of neurons scale with the size of the animal. Generally speaking, electrical resistances of neurons ...
Tópico(s): Ion channel regulation and function
2017 - American Physiological Society | Journal of Neurophysiology
C. F. Meehan, Kyle A. Mayr, Marin Manuel, Stan T. Nakanishi, Patrick J. Whelan,
The adult decerebrate mouse model (a mouse with the cerebrum removed) enables the study of sensory-motor integration and motor output from the spinal cord for several hours without compromising these functions with anesthesia. For example, the decerebrate mouse is ideal for examining locomotor behavior using intracellular recording approaches, which would not be possible using current anesthetized preparations. This protocol describes the steps required to achieve a low-blood-loss decerebration in ...
Tópico(s): Neuroscience and Neuropharmacology Research
2017 - Nature Portfolio | Nature Protocols
Barış Genç, Javier H. Jara, Megan C. Schultz, Marin Manuel, Macdonell J. Stanford, Mukesh Gautam, Jodi L. Klessner, Gabriella Sekerková, Daniel B. Heller, Gregory A. Cox, C. J. Heckman, Christine J. DiDonato, P. Hande Özdi̇nler,
Objective The aim of this study was to investigate the role of ubiquitin C-terminal hydrolase-L1 (UCHL1) for motor neuron circuitry and especially in spinal motor neuron (SMN) health, function, and connectivity. Methods Since mutations in UCHL1 gene leads to motor dysfunction in patients, we investigated the role of UCHL1 on SMN survival, axon health, and connectivity with the muscle, by employing molecular and cellular marker expression analysis and electrophysiological recordings, in healthy wild- ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2016 - Wiley | Annals of Clinical and Translational Neurology
Maren Ihlemann, Iasonas Kouveliotis‐Lysikatos, Jiangyi Huang, Jody Dillon, Ciara O’Dwyer, Topi Rasku, Marin Manuel, Kris Poncelet, Juha Kiviluoma,
The transition towards more sustainable energy systems poses new requirements on energy system models. New challenges include representing more uncertainties, including short-term detail in long-term planning models, allowing for more integration across energy sectors, and dealing with increased model complexities. SpineOpt is a flexible, open-source, energy system modelling framework for performing operational and planning studies, consisting of a wide spectrum of novel tools and functionalities. ...
Tópico(s): Distributed and Parallel Computing Systems
2022 - Elsevier BV | Energy Strategy Reviews
Clarissa F. Cavarsan, Preston R. Steele, Landon T. Genry, Emily J. Reedich, Lynn M. McCane, Kay J. LaPre, Alyssa Puritz, Marin Manuel, Natallia Katenka, Katharina A. Quinlan,
Abstract Few studies in amyotrophic lateral sclerosis (ALS) measure effects of the disease on inhibitory interneurons synapsing onto motoneurons (MNs). However, inhibitory interneurons could contribute to dysfunction, particularly if altered before MN neuropathology, and establish a long‐term imbalance of inhibition/excitation. We directly assessed excitability and morphology of glycinergic (GlyT2 expressing) ventral lumbar interneurons from SOD1G93AGlyT2eGFP (SOD1) and wild‐type GlyT2eGFP (WT) mice ...
Tópico(s): Nerve injury and regeneration
2022 - Wiley | The Journal of Physiology
Juha Kiviluoma, Fabiano Pallonetto, Marin Manuel, Pekka T. Savolainen, Antti Soininen, Per Vennström, Erkka Rinne, Jiangyi Huang, Iasonas Kouveliotis‐Lysikatos, Maren Ihlemann, Erik Delarue, Ciara O’Dwyer, Terence O’Donnel, Mikael Amelin, Lennart Söder, Jody Dillon,
The Spine Toolbox is open-source software for defining, managing, simulating and optimising energy system models. It gives the user the ability to collect, create, organise, and validate model input data, execute a model with selected data and finally archive and visualise results/output data. Spine Toolbox has been designed and developed to support the creation and execution of multivector energy integration models. It conveniently facilitates the linking of models with different scopes, or spatio- ...
Tópico(s): Simulation Techniques and Applications
2022 - Elsevier BV | SoftwareX
Seoan Huh, C. J. Heckman, Marin Manuel,
Although amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease, motoneuron electrical properties are already altered during embryonic development. Motoneurons must therefore exhibit a remarkable capacity for homeostatic regulation to maintain a normal motor output for most of the life of the patient. In the present article, we demonstrate how maintaining homeostasis could come at a very high cost. We studied the excitability of spinal motoneurons from young adult SOD1(G93A) ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2021 - Society for Neuroscience | eNeuro
Marcin Bączyk, Najwa Ouali Alami, Nicolas Delestrée, Clémence Martinot, Linyun Tang, Barbara Commisso, David Bayer, Nicolas Doisne, Wayne N. Frankel, Marin Manuel, Francesco Roselli, Daniel Zytnicki,
Excessive excitation is hypothesized to cause motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS), but actual proof of hyperexcitation in vivo is missing, and trials based on this concept have failed. We demonstrate, by in vivo single-MN electrophysiology, that, contrary to expectations, excitatory responses evoked by sensory and brainstem inputs are reduced in MNs of presymptomatic mutSOD1 mice. This impairment correlates with disrupted postsynaptic clustering of Homer1b, Shank, and ...
Tópico(s): Neuroscience and Neuropharmacology Research
2020 - Rockefeller University Press | The Journal of Experimental Medicine
Rémi Bos, Ronald M. Harris‐Warrick, Cécile Brocard, L. E. Demianenko, Marin Manuel, Daniel Zytnicki, S. М. Коrogod, Frédéric Brocard,
Spinal motoneurons are endowed with nonlinear spiking behaviors manifested by a spike acceleration whose functional significance remains uncertain. Here, we show in rodent lumbar motoneurons that these nonlinear spiking properties do not rely only on activation of dendritic nifedipine-sensitive L-type Ca2+ channels, as assumed for decades, but also on the slow inactivation of a nifedipine-sensitive K+ current mediated by Kv1.2 channels that are highly expressed in axon initial segments. Specifically, ...
Tópico(s): Advanced Memory and Neural Computing
2018 - Cell Press | Cell Reports
Marin Manuel, Matthieu K. Chardon, Vicki M. Tysseling, C. J. Heckman,
Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents compared with humans, being smaller and much more excitable. In contrast, feline motoneurons are more similar to those in humans. These scaling differences need to be taken into account for the use of rodents for translational studies of motor output.
Tópico(s): Mitochondrial Function and Pathology
2018 - American Physiological Society | Physiology
Julien Messéant, Alexandre Dobbertin, Emmanuelle Girard, Perrine Delers, Marin Manuel, Francesca Mangione, Alain Schmitt, Dominique Le Denmat, Jordi Molgó, Daniel Zytnicki, Laurent Schaeffer, Claire Legay, Laure Strochlic,
The muscle-specific kinase MuSK is one of the key molecules orchestrating neuromuscular junction (NMJ) formation. MuSK interacts with the Wnt morphogens, through its Frizzled-like domain (cysteine-rich domain [CRD]). Dysfunction of MuSK CRD in patients has been recently associated with the onset of myasthenia, common neuromuscular disorders mainly characterized by fatigable muscle weakness. However, the physiological role of Wnt-MuSK interaction in NMJ formation and function remains to be elucidated. ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2015 - Society for Neuroscience | Journal of Neuroscience
L Ritter, Matthew C. Tresch, C. J. Heckman, Marin Manuel, Vicki M. Tysseling,
The mouse is essential for genetic studies of motor function in both normal and pathological states. Thus it is important to consider whether the structure of motor output from the mouse is in fact analogous to that recorded in other animals. There is a striking difference in the basic electrical properties of mouse motoneurons compared with those in rats, cats, and humans. The firing evoked by injected currents produces a unique frequency-current (F-I) function that emphasizes recruitment of motor ...
Tópico(s): Neural dynamics and brain function
2014 - American Physiological Society | Journal of Neurophysiology
Marin Manuel, Yaqing Li, Sherif M. Elbasiouny, Katie Murray, Anna Griener, C. J. Heckman, David J. Bennett,
N-methyl-d-aspartate (NMDA) receptors are of critical importance for locomotion in the developing neonatal spinal cord in rats and mice. However, due to profound changes in the expression of NMDA receptors in development between the neonatal stages and adulthood, it is unclear whether NMDA receptors are still an important component of locomotion in the adult rodent spinal cord. To shed light on this issue, we have taken advantage of recently developed preparations allowing the intracellular recording ...
Tópico(s): Neuroscience and Neuropharmacology Research
2012 - American Physiological Society | Journal of Neurophysiology
Classical studies of the mammalian neuromuscular system have shown an impressive adaptation match between the intrinsic properties of motoneurons and the contractile properties of their motor units. In these studies, the rate at which motoneurons start to fire repetitively corresponds to the rate at which individual twitches start to sum, and the firing rate increases linearly with the amount of excitation (“primary range”) up to the point where the motor unit develops its maximal force. This allows ...
Tópico(s): Neuroscience and Neural Engineering
2011 - Society for Neuroscience | Journal of Neuroscience
Alain Frigon, Christopher K. Thompson, Michael D. Johnson, Marin Manuel, T. George Hornby, C. J. Heckman,
Extra forces or torques are defined as forces or torques that are larger than would be expected from the input or stimuli, which can be mediated by properties intrinsic to motoneurons and/or to the muscle. The purpose of this study was to determine whether extra forces/torques evoked during electrical stimulation of the muscle or its nerve with variable frequency stimulation are modulated by muscle length/joint angle. A secondary aim was to determine whether extra forces/torques are generated by ...
Tópico(s): Motor Control and Adaptation
2011 - Society for Neuroscience | Journal of Neuroscience
Caroline Iglesias, Claude Meunier, Marin Manuel, Yulia Timofeeva, Nicolas Delestrée, Daniel Zytnicki,
We explain the mechanism that elicits the mixed mode oscillations (MMOs) and the subprimary firing range that we recently discovered in mouse spinal motoneurons. In this firing regime, high-frequency subthreshold oscillations appear a few millivolts below the spike voltage threshold and precede the firing of a full blown spike. By combining intracellular recordings in vivo (including dynamic clamp experiments) in mouse spinal motoneurons and modeling, we show that the subthreshold oscillations are ...
Tópico(s): Neuroscience and Neural Engineering
2011 - Society for Neuroscience | Journal of Neuroscience