Maria Inês Alvelos, João Vinagre, Elsa Fonseca, Eva Barbosa, José Teixeira-Gomes, Manuel Sobrinho‐Simões, Paula Soares,
Primary hyperparathyroidism (pHPT) is characterised by an inappropriate over production of parathyroid hormone and it is the most frequent pathological condition of the parathyroid glands. A minority of the cases belong to familial forms, but most of them are sporadic. The genetic alterations underlying the sporadic forms of pHPT remain poorly understood. The main goal of our study is to perform the molecular characterisation of a series of sporadic pHPT cases.We have studied matched blood and tumour ...
Tópico(s): Genetic Syndromes and Imprinting
2012 - Oxford University Press | European Journal of Endocrinology
Raúl Moreno, David Dobarro, Esteban López de Sá, Mario Prieto, Carmen Morales, Luís Calvo Orbe, Isidro Moreno‐Gómez, David Filgueiras‐Rama, Ángel Sánchez‐Recalde, Guillermo Galeote, Santiago Jiménez‐Valero, J L López-Sendón,
... 96:6, Online publication date: 1-Nov-2020. Manuel A, Almeida J, Guerreiro C, Dias T, Barbosa A, Teixeira P, Ribeiro J, Dias A, Caeiro D, Fonseca ... 431-440), Online publication date: 1-Aug-2020. Manuel A, Almeida J, Guerreiro C, Dias T, Barbosa A, Teixeira P, Ribeiro J, Dias A, Caeiro D, Fonseca ...
Tópico(s): Cardiac pacing and defibrillation studies
2009 - Lippincott Williams & Wilkins | Circulation
Produção Nacional
Revisado por pares
Susana Lopes, José Mesquita‐Bastos, Catarina Garcia, Susana Bertoquini, Verónica Ribau, Manuel Teixeira, Ilda Patrícia Ribeiro, Joana Barbosa Melo, José Oliveira, Daniela Figueiredo, Guilherme Veiga Guimarães, Linda S. Pescatello, Jorge Polónia, Alberto J. Alves, Fernando Ribeiro,
Limited evidence suggests exercise reduces blood pressure (BP) in individuals with resistant hypertension, a clinical population with low responsiveness to drug therapy.To determine whether an aerobic exercise training intervention reduces ambulatory BP among patients with resistant hypertension.The Exercise Training in the Treatment of Resistant Hypertension (EnRicH) trial is a prospective, 2-center, single-blinded randomized clinical trial performed at 2 hospital centers in Portugal from March 2017 ...
Tópico(s): Ophthalmology and Visual Health Research
2021 - American Medical Association | JAMA Cardiology
Produção Nacional
Revisado por pares
Bruno Sousa, Cristiano Soares, Francisca Andréa da Silva Oliveira, Maria Martins, Simão Branco‐Neves, B. L. R. Barbosa, Inês Ataíde, Jorge Teixeira, Manuel Azenha, Ricardo Antunes Azevedo, Fernanda Fidalgo,
Although Solanum nigrum L. is a phytoremediator for different metals, its growth and physiology are still compromised by toxic levels of zinc (Zn). Thus, the development of eco-friendly strategies to enhance its tolerance, maintaining remediation potential is of special interest. This study evaluated the potential of 24-epibrassinolide (24-EBL) to boost S. nigrum defence against Zn towards a better growth rate and remediation potential. After 24 days of exposure, the results revealed that Zn-mediated ...
Tópico(s): Aluminum toxicity and tolerance in plants and animals
2019 - Elsevier BV | Chemosphere
Vanessa Coelho‐Santos, Filipa L. Cardoso, Ana Magalhães, Margarida Ferreira-Teixeira, Ricardo A. Leitão, Célia Gomes, Manuel Rito, Marcos Barbosa, Carlos Ribeiro, Ana Paula Silva,
Methylphenidate (MPH) is the classic treatment for attention deficit hyperactivity disorder (ADHD) among children and adults. Despite its beneficial effects, non-medical use of MPH is nowadays a problem with high impact on society. Thus, our goal was to uncover the neurovascular and cognitive effects of MPH chronic use during a critical period of development in control conditions. For that, male Wistar Kyoto rats were treated with MPH (1.5 or 5 mg/kg/day at weekdays, per os) from P28 to P55. We concluded ...
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - Elsevier BV | European Neuropsychopharmacology
O discurso pedagógico em torno da autonomia não é uma invenção recente, antes se prolonga nos anais da história, pelo menos a meados do século XVIII, altura em que se começaram a vislumbrar os princípios constitutivos de uma pedagogia da autonomia. Recentemente, e numa conjuntura que "obriga" as pessoas a serem autónomas, que as torna responsáveis por todos os aspectos das suas vidas, tenham ou não condições e recursos para os controlarem, esse discurso passou a ocupar um lugar de destaque nas reformas ...
Tópico(s): Diverse Education Studies and Reforms
2019 - Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira | Revista Brasileira de Estudos Pedagógicos
Ana Paula Fernandes Barbosa, Ana Peixoto, Pedro Pinto, Manuela Pinheiro, Manuel R. Teixeira,
Abstract Circulating cell-free DNA (cfDNA) consists of small fragments of DNA that circulate freely in the bloodstream. In cancer patients, a fraction of cfDNA is derived from tumour cells, therefore containing the same genetic and epigenetic alterations, and is termed circulating cell-free tumour DNA. The potential use of cfDNA, the so-called ‘liquid biopsy’, as a non-invasive cancer biomarker has recently received a lot of attention. The present review will focus on studies concerning the potential ...
Tópico(s): Renal cell carcinoma treatment
2018 - Cambridge University Press | Expert Reviews in Molecular Medicine
Produção Nacional
Revisado por pares
Bethany L. Clark, Ana P.B. Carneiro, Elizabeth J. Pearmain, Marie‐Morgane Rouyer, Thomas A. Clay, Win Cowger, Richard A. Phillips, Andrea Manica, Carolina Hazin, Marcus Eriksen, Jacob González‐Solís, Josh Adams, Yuri V. Albores‐Barajas, Joanna Alfaro‐Shigueto, Maria Alho, Deusa Teixeira Araujo, José Manuel Arcos, John P. Y. Arnould, Nadito J. P. Barbosa, Christophe Barbraud, Annalea Beard, Jessie Beck, Elizabeth Bell, Della G. Bennet, Maud Berlincourt, Manuel Biscoito, Oskar K. Bjørnstad, Mark Bolton, Katherine A. Booth Jones, John J. Borg, Karen Bourgeois, Vincent Bretagnolle, Joël Bried, James V. Briskie, M. de L. Brooke, Katherine Brownlie, Leandro Bugoni, Licia Calabrese, Letizia Campioni, Mark J. Carey, Ryan D. Carle, Nicholas Carlile, Ana R. Carreiro, Paulo Catry, Teresa Catry, Jacopo G. Cecere, Filipe R. Ceia, Yves Cherel, Chang‐Yong Choi, Marco Cianchetti‐Benedetti, Rohan H. Clarke, Jaimie Cleeland, Valentina Colodro, Bradley C. Congdon, Jóhannis Danielsen, Federico De Pascalis, Zoe Deakin, Nina Dehnhard, Giacomo Dell’Omo, Karine Delord, Sébastien Descamps, Ben J. Dilley, Herculano Dinis, Jérôme Dubos, Brendon J. Dunphy, Louise Emmerson, Ana Isabel Fagundes, Annette L. Fayet, Jonathan J. Felis, Johannes H. Fischer, Amanda N. D. Freeman, Aymeric Fromant, Giorgia Gaibani, David Barros‐García, Carina Gjerdrum, Ivandra Gomes, Manuela G. Forero, José P. Granadeiro, W. James Grecian, David Grémillet, Tim Guilford, Gunnar Þór Hallgrímsson, Luke R. Halpin, Erpur Snær Hansen, April Hedd, Morten Helberg, Hálfdán H. Helgason, Leeann M. Henry, Hannah F. R. Hereward, Marcos Hernández-Montero, Mark A. Hindell, Peter Hodum, Simona Imperio, Audrey Jaeger, Mark Jessopp, Patrick G. R. Jodice, Carl G. Jones, Christopher W. Jones, Jón Eínar Jónsson, Adam Kane, Sven Kapelj, Yuna Kim, Holly Kirk, Yann Kolbeinsson, Philipp L. Kraemer, Lucas Krüger, Paulo Lago, Todd J. Landers, Jennifer L. Lavers, Matthieu Le Corre, Andreia Leal, Maite Louzao, Jeremy Madeiros, Maria C. Magalhães, Mark L. Mallory, Juan F. Masello, Bruno Massa, Sakiko Matsumoto, Fiona McDuie, Laura McFarlane Tranquilla, Fernando Medrano, Benjamin Metzger, Teresa Militão, William A. Montevecchi, Rosalinda Carmela Montone, Leia Navarro‐Herrero, Verónica C. Neves, David G. Nicholls, Malcolm A. C. Nicoll, Ken Norris, Steffen Oppel, Daniel Oró, Ellie Owen, Oliver Padget, Vítor H. Paiva, David Pála, Jorge M. Pereira, Clara Péron, Maria Virgı́nia Petry, Admilton de Pina, Ariete T. Moreira Pina, Patrick Pinet, Pierre Pistorius, Ingrid L. Pollet, Benjamin J. Porter, Timothée Poupart, Christopher D. Powell, Carolina Proaño, Júlia Pujol-Casado, Petra Quillfeldt, John L. Quinn, André F. Raine, Helen Raine, Iván Ramírez, Jaime A. Ramos, Raül Ramos, Andréas Ravache, Matt J. Rayner, Timothy A. Reid, Gregory J. Robertson, Gérard Rocamora, Dominic P. Rollinson, Robert A. Ronconi, Andreu Rotger, Diego Rubolini, Kevin Ruhomaun, Asunción Ruiz, James C. Russell, Peter G. Ryan, Sarah Saldanha, Ana Sanz‐Aguilar, Mariona Sardà-Serra, Yvan G. Satgé, Katsufumi Sato, Wiebke C. Schäfer, Stefan Schoombie, Scott A. Shaffer, Nirmal Shah, Akiko Shoji, Dave Shutler, Ingvar A. Sigurðsson, Mónica C. Silva, Alison E. Small, Cecilia Soldatini, Hallvard Strøm, C. Surman, Akinori Takahashi, Vikash Tatayah, Graeme A. Taylor, Robert J. Thomas, David R. Thompson, Paul M. Thompson, Þorkell Lindberg Þórarinsson, Diego Vicente‐Sastre, Éric Vidal, Ewan D. Wakefield, Susan M. Waugh, Henri Weimerskirch, Heiko Wittmer, Takashi Yamamoto, Ken Yoda, Carlos B. Zavalaga, Francis Zino, Maria P. Dias,
Abstract Plastic pollution is distributed patchily around the world’s oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2023 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
Susana Lopes, José Mesquita‐Bastos, Catarina Garcia, Cátia Leitão, Verónica Ribau, Manuel Teixeira, Susana Bertoquini, Ilda Patrícia Ribeiro, Joana Barbosa Melo, José Oliveira, Daniela Figueiredo, Guilherme Veiga Guimarães, Linda S. Pescatello, Jorge Polónia, Alberto J. Alves, Fernando Ribeiro,
Tópico(s): Blood Pressure and Hypertension Studies
2023 - Springer Nature | Hypertension Research
Luís Leite, Rogério Teixeira, Manuel Oliveira‐Santos, António Barbosa, Rui Martins, Graça Castro, Lino Gonçalves, Mariano Pêgo,
Degenerative aortic valve disease (AVD) is a complex disorder that goes beyond valve itself, also undermining aortic wall. We aimed to assess the ascending aortic mechanics with two-dimensional speckle tracking echocardiography (2DSTE) in patients with aortic regurgitation (AR) and hypothesized a relationship with degree of AR. Aortic mechanics were then compared with those of similarly studied healthy controls and patients with aortic stenosis (AS); finally, we aimed to assess the prognostic significance ...
Tópico(s): Aortic Disease and Treatment Approaches
2016 - Wiley | Echocardiography
Produção Nacional
Revisado por pares
Márcio Cardoso, Ariane Santos da Silveira, Mateus Rodrigues de Vargas, José Manuel Marques Teixeira de Oliveira, Dante Vinicius Eloy Barbosa, Luiz Felipe Bertoldi de Oliveira, Aline Cambri Fredere, Vinícius Lôndero,
Earth's surface is a result of complex tectonic and erosional processes shaping landscapes and producing transient signs of different evolutionary stages. These transient signs are formed by a gradual adjustment of rivers to an equilibrium stage through channel incision and uplift. Processes have different magnitudes according to lithological contrasts and base-level changes that result in distinct disequilibrium phases of bedrock rivers. This integrated study of geomorphic indices in bedrock rivers ...
Tópico(s): earthquake and tectonic studies
2021 - Elsevier BV | Geomorphology
Ana Peixoto, Pedro Pinto, Joana Guerra, Manuela Pinheiro, Catarina Santos, Carla Pinto, Rui Pedro Santos, Carla Escudeiro, Carla Bartosch, R. Canário, Ana Paula Fernandes Barbosa, Alfredo Gouveia, Almerinda Petiz, Miguel Henriques Abreu, Susana Sousa, Deolinda Pereira, João Silva, Manuel R. Teixeira,
Deleterious variants in the BRCA1/BRCA2 genes and homologous recombination deficiency (HRD) status are considered strong predictors of response to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi). The introduction of PARPi in clinical practice for the treatment of patients with advanced ovarian cancer imposed changes in the molecular diagnosis of BRCA1/BRCA2 variants. BRCA1/BRCA2 tumor testing by next-generation sequencing (NGS) can detect simultaneously both somatic and germline variants, allowing ...
Tópico(s): CRISPR and Genetic Engineering
2020 - Frontiers Media | Frontiers in Oncology
Manuela Pinheiro, Ana Peixoto, Patrícia Rocha, Isabel Veiga, Carla Pinto, Catarina Santos, Pedro Pinto, Joana Guerra, Carla Escudeiro, Ana Paula Fernandes Barbosa, João Silva, Manuel R. Teixeira,
Tópico(s): Genetic factors in colorectal cancer
2022 - Springer Science+Business Media | International Journal of Colorectal Disease
Rute Alvarez, Susana Esteves, Sérgio Chacim, José Pedro Carda, Alexandra Mota, Manuel Guerreiro, Inês Amorim Monteiro Barbosa, Filipa Moita, Adriana Teixeira, Jorge Coutinho, Fernando Prı́ncipe, José Mariz, María Gomes da Silva,
Age is a negative prognostic factor in lymphomas, and elderly patients are often undertreated because of toxicity concerns. The pattern of treatment in elderly patients with diffuse large B-cell lymphoma (DLBCL) in Portugal has not been previously described.We conducted a multicenter retrospective study including 378 elderly patients with DLBCL receiving alkylating agent-containing regimens between 2003 and 2010. We compared the outcome of patients aged 60 to 79 years with patients > 79 years and analyzed ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2014 - Elsevier BV | Clinical Lymphoma Myeloma & Leukemia
Produção Nacional
Revisado por pares
Mayara Baptistucci Ogaki, Daniela R. Teixeira, Rosemary Vieira, Juan Manuel Lírio, João Paulo de Sá Felizardo, Rodrigo Coutinho Abuchacra, Renan Pereira Cardoso, Carlos Leomar Zani, Tânia Maria de Almeida Alves, Policarpo A.S., Silvane Maria Fonseca Murta, Emerson C. Barbosa, Jaquelline Germano de Oliveira, Isabela P. Cerávolo, Patrícia O. Pereira, Carlos A. Rosa, Luiz Henrique Rosa,
We recovered 195 fungal isolates from the sediments of different lakes in the Antarctic Peninsula, which were screened to detect bioactive compounds. Forty-two taxa belonging to the phyla Ascomycota, Basidiomycota, and Mortierellomycota were identified. Thelebolus globosus, Antarctomyces psychrotrophicus, Pseudogymnoascus verrucosus, Vishniacozyma victoriae, and Phenoliferia sp. were found to be the most prevalent. The fungal assemblages showed high diversity and richness, but low dominance values. ...
Tópico(s): Protist diversity and phylogeny
2020 - Elsevier BV | Fungal Biology
Produção Nacional
Revisado por pares
Mario A. Parra, Sandra Báez, Lucas Sedeño, Cecilia González Campo, Hernando Santamaría‐García, Ivan Aprahamian, Paulo Henrique Ferreira Bertolucci, Julián Bustin, Maria Aparecida Camargos Bicalho, Carlos Cano, Paulo Caramelli, Márcia Lorena Fagundes Chaves, Patricia Cogram, Bárbara Costa Beber, Felipe A. Court, Leonardo Cruz de Souza, Nilton Custodio, Andrés Damián, Myriam De la Cruz Puebla, Roberta Diehl Rodriguez, Sônia Maria Dozzi Brucki, Laís Fajersztajn, Gonzalo Farías, Fernanda G. De Felice, Raffaele Ferrari, Fabricio Ferreira de Oliveira, Sérgio T. Ferreira, Renata Eloah de Lucena Ferretti‐Rebustini, Márcio Luiz Figueredo Balthazar, Norberto Anízio Ferreira Frota, Patricio Fuentes, Adolfo M. García, Patricia García, Fábio Henrique de Gobbi Porto, Lissette Duque Peñailillo, Henry Engler, Irene Maier, Ignácio F. Mata, Christian González‐Billault, Oscar L. López, Laura Morelli, Ricardo Nitríni, Yakeel T. Quiroz, Alejandra Guerrero Barragán, David Huepe, Fabricio Joao Pio, Cláudia Kimie Suemoto, Renata Kochhann, Silvia Kochen, Fiona Kumfor, Serggio Lanata, Bruce L. Miller, Letı́cia Lessa Mansur, Mirna Lie Hosogi, Patricia Lillo, Jorge Llibre Guerra, David Lira, Francisco Lopera, Adelina Comas, José Alberto Ávila‐Funes, Ana Luisa Sosa, Cláudia Ramos, Elisa de Paula França Resende, Heather M. Snyder, Ioannis Tarnanas, Jenifer Yokoyama, Juan Llibre, Juan F. Cardona, Kate L Possin, Kenneth S. Kosik, Rosa Montesinos, Sebastián Moguilner, Patricia Cristina Lourdes Solis, Renata Eloah de Lucena Ferretti‐Rebustini, Jeronimo Martin Ramirez, Diana Matallana, Lingani Mbakile‐Mahlanza, Alyne Mendonça Marques Ton, Ronnielly Melo Tavares, Eliane Correa Miotto, Graciela Muñiz‐Terrera, Luis Arnoldo Muñoz‐Nevárez, David Orozco, Maira Okada de Oliveira, Olivier Piguet, Maritza Pintado Caipa, Stefanie Danielle Piña‐Escudero, Lucas Porcello Schilling, André Luiz Rodrigues Palmeira, Mônica Sanches Yassuda, José Manuel Santacruz Escudero, Rodrigo Bernardo Serafim, Jerusa Smid, Andrea Slachevsky, Cecília Serrano, Marcio Soto‐Añari, Leonel Tadao Takada, Lea T. Grinberg, Antônio Lúcio Teixeira, Maira Tonidandel Barbosa, Dominic Trepél, Agustín Ibáñez,
Abstract Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence‐ ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2020 - Wiley | Alzheimer s & Dementia
Inês Moreira, Marta Ferreira, S. Garcia, Pedro Novais, João Martins Gama, Beatriz Ferro, Pedro Leite‐Silva, Cristina Frutuoso, Mónica Pires, Ana Paula Fernandes Barbosa, Carla Pinto, Manuel R. Teixeira, Deolinda Pereira, Carla Bartosch,
Tópico(s): Genetic factors in colorectal cancer
2023 - Elsevier BV | Gynecologic Oncology
João Figueira, David Martins, Bernardete Pessoa, Natália Ferreira, Angelina Meireles, António Sampaio Soares, Ângela Carneiro, F Vaz, João Nascimento, Natacha Moreno, José Roque, Manuel Domingues, Rita Flores, Carla Teixeira, Eduardo Conde, Filipe Henriques, Helena Proença, José Pita Negrão, Marisa Barbosa, Rufino Silva, Sara Vaz-Pereira, Pedro Neves, Nuno Gomes, Miguel Raimundo,
<b><i>Aim:</i></b> Evaluate the real-life experience with ocriplasmin on vitreomacular traction (VMT) release and full-thickness macular hole (FTMH) closure in Portugal. <b><i>Methods:</i></b> Multicentric, retrospective study of 83 eyes of 78 patients who were treated with intravitreal ocriplasmin for VMT with and without FTMH. Primary outcomes were VMT release and FTMH closure. Secondary outcomes included visual acuity changes and structural features on ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2016 - Karger Publishers | Ophthalmic Research
José Garcia‐Pelaez, Rita Barbosa‐Matos, Silvana Lobo, Alexandre Dias, Luzia Garrido, Sérgio Castedo, Sónia Sousa, Hugo Pinheiro, Liliana Sousa, Rita Monteiro, Joaquín J. Maqueda, Susana Fernandes, Fátima Carneiro, Nádia Pinto, Carolina Lemos, Carla Pinto, Manuel R. Teixeira, Stefan Aretz, Svetlana Lagercrantz, Judith Balmañà, Ana Blatnik, Patrick R. Benusiglio, Maud Blanluet, Vincent Bours, Hilde Brems, Joan Brunet, Daniele Calistri, Gabriel Capellá, Sergio Carrera, Chrystelle Colas, Karin Dahan, Robin De Putter, Camille Desseignés, Elena Domínguez‐Garrido, Conceição Egas, D. Gareth Evans, Damien Féret, Eleanor Fewings, Rebecca C. Fitzgerald, Florence Coulet, María Garcia-Barcina, Maurizio Genuardi, Lisa Golmard, Karl Hackmann, Helen Hanson, Elke Holinski‐Feder, Robert Hüneburg, Mateja Krajc, Kristina Lagerstedt‐Robinson, Conxi Lázaro, Marjolijn J.L. Ligtenberg, Cristina Martínez-Bouzas, Sonia Merino, G Michils, Srdjan Novaković, Ana Patiño‐García, Guglielmina Nadia Ranzani, Evelin Schröck, Inês Pires da Silva, Catarina Silveira, José Luís Soto, Isabel Spier, Verena Steinke‐Lange, Gianluca Tedaldi, María‐Isabel Tejada, Emma R. Woodward, Marc Tischkowitz, Nicoline Hoogerbrugge, Carla Oliveíra,
Background Truncating pathogenic or likely pathogenic variants of CDH1 cause hereditary diffuse gastric cancer (HDGC), a tumour risk syndrome that predisposes carrier individuals to diffuse gastric and lobular breast cancer.Rare CDH1 missense variants are often classified as variants of unknown significance.We conducted a genotypephenotype analysis in families carrying rare CDH1 variants, comparing cancer spectrum in carriers of pathogenic or likely pathogenic variants (PV/LPV; analysed jointly) or ...
Tópico(s): Genomics and Rare Diseases
2022 - Elsevier BV | The Lancet Oncology
Ana Mosalina Manuel, João Almeida, Paulo Fonseca, J Monteiro, Cláudio Guerreiro, Ana Raquel Barbosa, Pedro Teixeira, José Ribeiro, Elisabeth Santos, F Rosas, José Ribeiro, Adelaide Dias, Daniel Caeiro, Olga Sousa, Madalena Teixeira, Marco Oliveira, Helena Gonçalves, João Primo, Pedro Braga,
In patients with supraventricular arrhythmias and high ventricular rate, unresponsive to rate and rhythm control therapy or catheter ablation, atrioventricular (AV) node ablation may be performed. To assess long-term outcomes after AV node ablation and to analyze predictors of adverse events. We performed a detailed retrospective analysis of all patients who underwent AV node ablation between February 1997 and February 2019, in a single Portuguese tertiary center. A total of 123 patients, mean age ...
Tópico(s): Cardiac pacing and defibrillation studies
2021 - Elsevier BV | Revista Portuguesa de Cardiologia
Produção Nacional
Revisado por pares
Germana Silva Vasconcelos, Manuel Alves Dos Santos Júnior, Aline Santos Monte, Francisco Eliclécio Rodrigues da Silva, Camila Nayane de Carvalho Lima, Abelardo Barbosa Moreira Lima Neto, Ingridy da Silva Medeiros, Antônio Lúcio Teixeira, David Freitas de Lucena, Silvânia Maria Mendes Vasconcelos, Danielle Macêdo,
Schizophrenia is a severe mental disorder with complex etiopathogenesis. Based on its neurodevelopmental features, an animal model induced by "two-hit" based on perinatal immune activation followed by peripubertal unpredictable stress was proposed. Sex influences the immune response, and concerning schizophrenia, it impacts the age of onset and symptoms severity. The neurobiological mechanisms underlying the influence of sex in schizophrenia is poorly understood. Our study aimed to evaluate sex influence ...
Tópico(s): Neuroendocrine regulation and behavior
2021 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Produção Nacional
Revisado por pares
Morgan Schmidt, Samuel L. Goldberg, Michael Heckenberger, Carlos Fausto, Bruna Franchetto, Jennifer Watling, Helena Pinto Lima, Bruno Moraes, Wetherbee Dorshow, Joshua Toney, Yamalui Kuikuro, Kumessi Waura, Huke Kuikuro, Taku Wate Kuikuro, Takumã Kuikuro, Yahila Kuikuro, Afukaka Kuikuro, Wenceslau Geraldes Teixeira, Bruna Rocha, Vinicius Honorato de Oliveira, Hugo Tavares, Marcos Pereira Magalhães, Carlos Augusto de Melo Barbosa, João Aires da Fonseca, Kelton Mendes, Luís Reynaldo Ferracciú Alleoni, Carlos Eduardo Pellegrino Cerri, Manuel Arroyo‐Kalin, Eduardo Góes Neves, J. Taylor Perron,
Fertile soil known as Amazonian dark earth is central to the debate over the size and ecological impact of ancient human populations in the Amazon. Dark earth is typically associated with human occupation, but it is uncertain whether it was created intentionally. Dark earth may also be a substantial carbon sink, but its spatial extent and carbon inventory are unknown. We demonstrate spatial and compositional similarities between ancient and modern dark earth and document modern Indigenous practices ...
Tópico(s): Isotope Analysis in Ecology
2023 - American Association for the Advancement of Science | Science Advances
Ana Paula Fernandes Barbosa, Pedro Pinto, Ana Peixoto, Joana Guerra, Carla Pinto, Catarina Santos, Manuela Pinheiro, Carla Escudeiro, Carla Bartosch, João Silva, Manuel R. Teixeira,
Since the approval of PARP inhibitors for the treatment of high-grade serous ovarian cancer, in addition to cancer risk assessment, BRCA1 and BRCA2 genetic testing also has therapeutic implications (germline and somatic variants) and should be offered to these patients at diagnosis, irrespective of family history. However, variants in other genes besides BRCA1 and BRCA2 are associated with ovarian cancer predisposition, which would be missed by a genetic testing aimed only at indication for PARP ...
Tópico(s): CRISPR and Genetic Engineering
2020 - Multidisciplinary Digital Publishing Institute | Cancers
João Fonseca, José Eduardo Mateus, Benilde Barbosa, Manuel Teixeira Veríssimo, Armando Carvalho,
Sarcoidosis is a systemic granulomatous disease of unknown etiology with a wide range of clinical presentations. Authors describe the case of a 72-year-old man with severe acute renal injury secondary to granulomatous interstitial nephritis. Despite the suggestive renal biopsy, only the exclusion of other granulomatous diseases enabled the definitive diagnosis of renal sarcoidosis. The patient underwent hemodialysis and therapy with prednisolone 1mg/kg/day. His serum creatinine returned to baseline ...
Tópico(s): Drug-Induced Adverse Reactions
2017 - | The International Annals of Medicine
Joana Gomes, Helena Temido, David Donaire-González, M. G. Petrova, B. Barbosa, Manuel Teixeira Veríssimo, Armando Carvalho,
Tópico(s): Orthopedic Surgery and Rehabilitation
2015 - Elsevier BV | European Geriatric Medicine
J.P.F. Fonseca, Daniel Ferreira, Anabela Mendes, P.L. Lopes, H.C. Hugo, Rosa Ferreira, Hélder Esperto, Marta Simões, B. Barbosa, Manuel Teixeira Veríssimo,
Tópico(s): Congenital heart defects research
2014 - Elsevier BV | European Geriatric Medicine
L. Ruzickova, Catarina Canha, L. Geraldes, Paulo Cesar, José Pedro Carda, Nuno Vasco Costa, B. Barbosa, Manuel Teixeira Veríssimo, J. Costa,
Introduction: Superior vena cava syndrome (SVCS) is a group of symptoms that occurs when vena cava superior is partly or completely blocked. Obstruction can occur due to external pressure, involvement of the vessel by tumour tissue, or thrombotic event. Most SVC syndromes are associated with malignant disease. Primary Mediastinal B-cell lymphoma is a distinctive subtype of Non-Hodgkin lymphoma with specific clinicopathologic aspects and aggressive behaviour. This malignancy is characterized by rapid ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2013 - Elsevier BV | European Journal of Internal Medicine
J.P.F. Fonseca, José Gago, Andreia Chaves, Marília Gomes, Maria del Robledo Avila Castellano, Rita Garcia, B. Barbosa, Manuel Teixeira Veríssimo,
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2012 - Elsevier BV | European Geriatric Medicine
Ana Mosalina Manuel, João Almeida, Cláudio Guerreiro, Tiago Dias, Ana Raquel Barbosa, Pedro Teixeira, José Ribeiro, Adelaide Dias, Daniel Caeiro, Marlene Fonseca, Madalena Teixeira, Marco Oliveira, Helena Gonçalves, João Primo, Alberto Rodrigues, Vasco Gama, Pedro Braga, Ricardo Fontes‐Carvalho,
Transcatheter aortic valve implantation (TAVI) is associated with cardiac electrical disturbances. However, beyond the risks of pacemaker implantation, few studies have performed a detailed assessment of the effects of TAVI on several cardiac electrical properties. To assess the frequency and type of electrocardiographic disturbances following TAVI, according to the type of prostheses and to assess predictors of these disturbances. We performed a detailed retrospective analysis of all electrocardiograms ...
Tópico(s): Cardiac Arrhythmias and Treatments
2020 - Elsevier BV | Revista Portuguesa de Cardiologia
Maria João Martins, Inês Laíns, Bruno Brochado, Manuel Oliveira‐Santos, Pedro Pinto Teixeira, Mariana Brandão, Rui Cerqueira, Ricardo Castro‐Ferreira, Carlos Bernardes, Miguel Nobre Menezes, Bernardo Baptista, Ricardo Ladeiras‐Lopes, Mariana Cruz Rei, Gilberto Pires da Rosa, José Luís Pereira Martins, Maria Sanches, Manuel J. Ferreira‐Pinto, Margarida Rato, Miguel Costa‐Silva, Catarina Policiano, João Beato, João Barbosa‐Breda, João Pimentel Torres, Inês Leal, Sílvia Aguiar Rosa, Bárbara Ribeiro, Francisco Costa, Carolina Palmela, Tiago Cúrdia Gonçalves, Luís Morais, Tiago Reis Marques,
The satisfaction with the medical profession has been identified as an essential factor for the quality of care, the wellbeing of patients and the healthcare systems' stability. Recent studies have emphasized a growing discontent of physicians, mainly as a result of changes in labor relations.To assess the perception of Portuguese medical residents about: correspondence of residency with previous expectations; degree of satisfaction with the specialty, profession and place of training; reasons for ...
Tópico(s): Patient Satisfaction in Healthcare
2015 - Ordem dos Médicos | Acta Médica Portuguesa