Maria Inês Alvelos, João Vinagre, Elsa Fonseca, Eva Barbosa, José Teixeira-Gomes, Manuel Sobrinho‐Simões, Paula Soares,
Primary hyperparathyroidism (pHPT) is characterised by an inappropriate over production of parathyroid hormone and it is the most frequent pathological condition of the parathyroid glands. A minority of the cases belong to familial forms, but most of them are sporadic. The genetic alterations underlying the sporadic forms of pHPT remain poorly understood. The main goal of our study is to perform the molecular characterisation of a series of sporadic pHPT cases.We have studied matched blood and tumour ...
Tópico(s): Genetic Syndromes and Imprinting
2012 - Oxford University Press | European Journal of Endocrinology
Produção Nacional
Revisado por pares
Alexandre Guilherme Zabeu Rossi, Regina Célia Teixeira Gomes, Manuel de Jesus Simões, Ricardo Santos Simões, Patrícia Bedesco de Oliveira, José Maria Soares, Edmund Chada Baracat,
To evaluate the effects of metoclopramide-induced hyperprolactinemia on the prolactin receptor of murine endometrium.Experimental study using the RNA extraction to detect tissue prolactin receptor isoforms by reverse-transcriptase polymerase chain reaction (RT-PCR).University-based laboratory.Seventy-two female swiss albino mice (Mus musculus), approximately 100 days old, were divided into six 12-animal groups: (GI) nonoophorectomized mice given vehicle; (GII) nonoophorectomized mice treated with metoclopramide; ( ...
Tópico(s): Reproductive System and Pregnancy
2009 - Elsevier BV | Fertility and Sterility
Paula Boaventura, Paula Soares, Dina Pereira, José Teixeira-Gomes, Manuel Sobrinho‐Simões,
We read with interest Shifra Shvarts and colleagues' Historical Review on the tinea capitis treatment campaign in 1950s Serbia.1Shvarts S Sevo G Tasic M et al.The tinea capitis campaign in Serbia in the 1950s.Lancet Infect Dis. 2010; 10: 571-576Summary Full Text Full Text PDF PubMed Scopus (21) Google Scholar Treatment of tinea capitis infection that included radiation was also used in Portugal in the same period, in accordance with the same Kienbock-Adamson technique.2Brandão N The roentgentherapy ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2011 - Elsevier BV | The Lancet Infectious Diseases
Filipe Nery, Diana Valadares, Sara Moráis, Manuel Teixeira Gomes, Andrea De Gottardi,
In acute portal vein thrombosis (APVT) unrelated to cirrhosis, anticoagulant therapy is classically started with low molecular weight heparin or vitamin K antagonists. New direct-acting oral anticoagulants (DOACs) are used in the treatment of venous thrombosis outside the splanchnic vascular bed, but not in the latter. We report a young female with APVT occurring in a non-cirrhotic liver linked to heterozygosity of factor V-Leiden and prothrombin G20210A gene mutations. Rivaroxaban was started, with ...
Tópico(s): Case Reports on Hematomas
2017 - | Gastroenterology Research
Sanjay Misra, Manuel Teixeira Gomes, Verghese Mathew, Gregory W. Barsness, Stephen C. Textor, Haraldur Bjarnason, Michael A. McKusick,
Purpose To present clinical outcomes with the use of embolic protection devices (EPDs) and renal artery stents in patients with chronic renal insufficiency (CRI) and renal artery stenosis (RAS). Materials and Methods A retrospective study was conducted in 23 patients with RAS and CRI who were treated with renal artery stent placement with an EPD. Follow-up data were obtained through medical records. Results In 23 patients (18 men; 78%) with an average age of 69.4 years ± 11 (range, 46–86 y), 32 renal arteries ...
Tópico(s): Aortic aneurysm repair treatments
2008 - Elsevier BV | Journal of Vascular and Interventional Radiology
Produção Nacional
Revisado por pares
Filipe Nery, Paula Carneiro, Sofia Correia, Carlos Sampaio Macedo, Judit Gandara, Vítor Lopes, Diana Valadares, Sofia Ferreira, João Oliveira, Manuel Teixeira Gomes, Helena Miranda, Pierre‐Emmanuel Rautou, Dominique Valla,
Various risk factors for portal vein thrombosis (PVT) development in patients with cirrhosis have been identified, but the role of systemic inflammatory reaction is unknown. The study aims to assess the association between markers of systemic inflammation and PVT in cirrhosis.Between January 2014 and October 2015, 107 outpatients with cirrhosis and no PVT were recruited, and followed till February 2017. White blood cell count, serum concentrations of high-sensitive C-reactive protein, ferritin, tumor ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2020 - Lippincott Williams & Wilkins | European Journal of Gastroenterology & Hepatology
Filipe Nery, Sofia Correia, Carlos Sampaio Macedo, Judit Gandara, Vítor Lopes, Diana Valadares, Sofia Ferreira, João Oliveira, Manuel Teixeira Gomes, Raquel Lucas, Pierre‐Emmanuel Rautou, Helena Miranda, Dominique Valla,
Summary Background Nonmalignant portal vein thrombosis is a significant event in the course of cirrhosis that can contraindicate liver transplantation and even impact survival after the surgical procedure. Risk factors are not completely known or validated and are still debated. Aim To identify in patients with cirrhosis the risk factors for portal vein thrombosis that are assessable in clinical practice. Methods Between January 2014 and February 2017, 108 outpatients with cirrhosis and no portal ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2019 - Wiley | Alimentary Pharmacology & Therapeutics
Paula Boaventura, Dina Pereira, Adélia Mendes, Rui Batısta, André Ferreira da Silva, Isabel Guimarães, Mrinalini Honavar, José Teixeira-Gomes, José Manuel Lopes, Valdemar Máximo, Paula Soares,
Basal cell carcinoma (BCC) is the most frequent skin cancer. An elevated prevalence of BCC has been associated with radiation, namely after the Tinea capitis epilation treatment, being these tumors described as more aggressive. Mitochondrial DNA (mtDNA) mutations have been reported in many human tumors, but their occurrence in BCC is poorly documented.The purpose of this work was to evaluate BCC histological subtypes in individuals subjected to X-ray epilation for Tinea capitis treatment when compared ...
Tópico(s): Polyomavirus and related diseases
2013 - Elsevier BV | Journal of Dermatological Science
Paula Boaventura, Dina Pereira, Adélia Mendes, José Teixeira-Gomes, Manuel Sobrinho‐Simões, Paula Soares,
Tópico(s): Cancer Diagnosis and Treatment
2014 - Springer Science+Business Media | Virchows Archiv
Paula Boaventura, Dina Pereira, Ricardo Celestino, Adélia Mendes, Tadao Nakasawa, José Teixeira-Gomes, Manuel Sobrinho‐Simões, Paula Soares,
Exposure to ionizing radiation at young age is the strongest risk factor for the occurrence of papillary thyroid carcinoma (PTC). RET/PTC rearrangements are the most frequent genetic alterations associated with radiation-induced PTC, whereas BRAF and RAS mutations and PAX8-PPARG rearrangement have been associated with sporadic PTC. We decided to search for such genetic alterations in PTCs of patients subjected in childhood to scalp irradiation.We studied 67 thyroid tumors from 49 individuals irradiated ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2013 - Oxford University Press | European Journal of Endocrinology
João Soares‐Fernandes, Roseli Teixeira-Gomes, Romeu Cruz, Manuel Ribeiro, Z Magalhães, Jaime F. Rocha, Lara M. Leijser,
Tópico(s): Neonatal and fetal brain pathology
2008 - Springer Science+Business Media | Pediatric Radiology
Luísa Lobato, Alessandra Ventura, Idalina Beirão, Helena Miranda, R. Seca, Águida Cristina Gomes Henriques, Manuel Teixeira, António Sarmento, Mirian Cláudia de Souza Pereira,
AUTOSOMAL dominant amyloidoses characterized so far are most commonly associated with transthyretin (TTR), a plasma protein synthesized by the liver. The single gene for TTR is located on human chromosome 18; more than 70 TTR mutations have been documented. The most common type of hereditary amyloidosis is familial amyloid polyneuropathy type I (FAP, Portuguese type), a neuropathic form associated with a substitution of methionine for valine at position 30 of the TTR gene, TTR Val30Met. The largest ...
Tópico(s): Trace Elements in Health
2003 - Elsevier BV | Transplantation Proceedings
Vanessa Coelho‐Santos, Filipa L. Cardoso, Ana Magalhães, Margarida Ferreira-Teixeira, Ricardo A. Leitão, Célia Gomes, Manuel Rito, Marcos Barbosa, Carlos Ribeiro, Ana Paula Silva,
Methylphenidate (MPH) is the classic treatment for attention deficit hyperactivity disorder (ADHD) among children and adults. Despite its beneficial effects, non-medical use of MPH is nowadays a problem with high impact on society. Thus, our goal was to uncover the neurovascular and cognitive effects of MPH chronic use during a critical period of development in control conditions. For that, male Wistar Kyoto rats were treated with MPH (1.5 or 5 mg/kg/day at weekdays, per os) from P28 to P55. We concluded ...
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - Elsevier BV | European Neuropsychopharmacology
Márcia T. Rodrigues, Manuela E. Gomes, Carlos Viegas, Jorge Manuel Teixeira de Azevedo, Isabel R. Dias, Fernando Muñóz, Rui L. Reis,
This study aims to assess the in vivo performance of cell-scaffold constructs composed of goat marrow stromal cells (GBMCs) and SPCL (a blend of starch with polycaprolactone) fibre mesh scaffolds at different stages of development, using an autologous model. GBMCs from iliac crests were seeded onto SPCL scaffolds and in vitro cultured for 1 and 7 days in osteogenic medium. After 1 and 7 days, the constructs were characterized for proliferation and initial osteoblastic expression by alkaline phosphatase ( ...
Tópico(s): Periodontal Regeneration and Treatments
2010 - Wiley | Journal of Tissue Engineering and Regenerative Medicine
Clarisse Nobre, Sérgio Sousa, Soraia P. Silva, Ana C. Pinheiro, Elisabete Coelho, A. A. Vicente, Ana Gomes, Manuel A. Coimbra, J. A. Teixeira, L. R. Rodrigues,
The bifidogenic potential of fructo-oligosaccharides (FOS) produced by a newly isolated strain – Aspergillus ibericus was studied. Their activity was compared to FOS produced by Aureobasidium pullulans and to a non-microbial commercial FOS sample (Raftilose® P95). FOS fermentability by a number of probiotic bacteria and their hydrolytic resistance to the simulated harsh conditions of the digestive system was evaluated. Aspergillus ibericus FOS sample effectively promoted probiotic bacteria growth. Overall, ...
Tópico(s): Probiotics and Fermented Foods
2018 - Elsevier BV | Journal of Functional Foods
... Hoffmann, e “Sede de sangue” (1909), do português Manuel Teixeira-Gomes. Embora tenham propostas narrativas e estilos diferentes, procura- ...
Tópico(s): Cultural, Media, and Literary Studies
2022 - UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO | Abusões
Severiano Silva, J. Afonso, Cristina Guedes, Maria José Gomes, Virgínia Santos, Jorge Manuel Teixeira de Azevedo, A. Dias‐da‐Silva,
The relationship between ultrasound measurements and the empty body chemical composition of mature ewes was studied in two breeds. The breeds were a milk-producing breed Churra da Terra Quente—CTQ (n = 33; live weight 42.0 ± 7.3 kg, mean ± SD), and a meat breed Ile de France—IF (n = 23; live weight 60.7 ± 9.1 kg, mean ± SD). Fat and muscle depths were measured in the live animals by real-time ultrasound scanning (RTU; 7.5 MHz probe) over the 13th thoracic, and between the 3rd and 4th lumbar vertebrae, and total ...
Tópico(s): Animal Nutrition and Physiology
2016 - Elsevier BV | Small Ruminant Research
Jorge Lima, José Teixeira-Gomes, Paula Soares, Valdemar Máximo, Mrinalini Honavar, Dillwyn Williams, Manuel Sobrinho‐Simões,
C cell hyperplasia is associated with medullary carcinoma of the thyroid in the inherited MEN2 syndromes, in which the great majority of cases have been shown to be due to a mutation in the RET oncogene. We report a study of a family with C cell hyperplasia and hypercalcitoninemia in which no cases of medullary carcinoma have yet occurred and which lacked an identifiable causative RET mutation. Four of the family members showed hypercalcitoninemia, and marked C cell hyperplasia was present in each ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2003 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Produção Nacional
Revisado por pares
Vitor Tajra, Ramires Alsamir Tibana, Denis César Leite Vieira, Darlan Lopes de Farias, Tatiane Gomes Teixeira, Silvana Schwerz Funghetto, Alessandro de Oliveira Silva, Nuno Manuel Frade de Sousa, Jeffrey M. Willardson, Margô Gomes de Oliveira Karnikowski, Jonato Prestes,
Objectives Resistance exercise is used as a non-pharmacological tool to elicit both gains in and maintenance of physical function in the elderly. Thus, the present study examined the acute response of creatine kinase and interleukin-6 following an eccentric resistance exercise session in elderly obese women classified as high responders or normal responders. Design Cross-sectional field study. Methods Ninety elderly obese women (69.4 ± 6.01 years) were tested for a 10 repetition maximum on the leg ...
Tópico(s): Muscle metabolism and nutrition
2013 - Elsevier BV | Journal of science and medicine in sport
Jorge Malheiro, La Salete Martins, Isabel Fonseca, AC Gomes, Josefina Santos, L. Dias, Jorge Dores, Filomena Oliveira, R. Seca, R. Almeida, Águida Cristina Gomes Henriques, António Cabrita, Manuel Teixeira,
Simultaneous pancreas-kidney transplantation (SPK) is the treatment of choice for selected diabetic patients with end-stage renal disease. Maintenance steroid therapy is associated with significant morbidity and mortality among SPK transplant recipients. Steroid withdrawal regimens are becoming more common, albeit with reservations regarding its safety and efficacy. We performed a retrospective review of 77 SPK transplant recipients from May 2000 to December 2007. The subjects received induction ...
Tópico(s): Neurological Complications and Syndromes
2009 - Elsevier BV | Transplantation Proceedings
Produção Nacional
Revisado por pares
Silvana Schwerz Funghetto, Jonato Prestes, Alessandro de Oliveira Silva, Darlan Lopes de Farias, Tatiane Gomes Teixeira, Denis César Leite Vieira, Vinícius Carius de Souza, Nuno Manuel Frade de Sousa, James W. Navalta, Gislane Ferreira de Melo, Margô Gomes de Oliveira Karnikowski,
The IL-6 gene polymorphism has been associated with disease prevalence and different physiological responses to exercise. Eccentric resistance exercise (ERE) is considered a nonpharmacological tool to prevent the chronic degenerative profile associated with aging and obesity. Consequently, the aim of the present study was to investigate the influence of IL-6 -174G/C polymorphism on acute interleukin-6 (IL-6) and creatine kinase (CK) temporal response to ERE in elderly obese women. Ninety women completed ...
Tópico(s): Muscle metabolism and nutrition
2013 - Elsevier BV | Experimental Gerontology
Produção Nacional
Revisado por pares
Gabriela Carolina C. Cristofani Maioral, Regina C. Teixeira Gomes, Carina Verna, Manuel de Jesus Simões, Helena B. Nader, Ricardo Santos Simões, Edmund Chada Baracat, José Maria Soares,
The aim of this study was to evaluate the amount of non- and sulfated glycosaminoglycans in the ovariectomized mice uterus, after treatment with ovarian steroids. For this purpose, 50 adult female mice were divided into five groups with 10 animals/each: control group: CG (ovary intact), and ovariectomized groups: OG (vehicle), EG (estradiol), PG (progesterone) and EPG (estradiol combined to progesterone). The treatments started 30 days after ovariectomy. All the animals were treated for 50 consecutive ...
Tópico(s): Reproductive Physiology in Livestock
2016 - Informa | Gynecological Endocrinology
Tópico(s): Historical Education and Society
2018 - Fundacao Calouste Gulbenkian | Colóquio. Letras
Tópico(s): History, Culture, and Society
2018 - | Metamorfoses - Revista de Estudos Literários Luso-Afro-Brasileiros
Ana Alexandra Seabra de Carvalho,
Tópico(s): History, Culture, and Society
2010 - Fundacao Calouste Gulbenkian | Colóquio. Letras
João Requicha, Carlos Viegas, Carlos Albuquerque, Jorge Manuel Teixeira de Azevedo, Rui L. Reis, Manuela E. Gomes,
Tópico(s): 3D Printing in Biomedical Research
2012 - Springer Science+Business Media | Stem Cell Reviews and Reports
Produção Nacional
Revisado por pares
Maria Izabel Gomès Silva, Manuel Rufino de Aquino Neto, Paulo Florentino Teixeira Neto, Brinell Arcanjo Moura, Jeferson Falcão do Amaral, Damião Pergentino de Sousa, Silvânia Maria Mendes Vasconcelos, Francisca Cléa Florenço de Sousa,
Isopulegol is a monoterpene alcohol intermediate in the preparation of (-)-menthol and it is present in the essential oils of various plants. This work presents behavioral effects of isopulegol in animal models of open field, elevated plus maze (EPM), rota rod, hole board, barbiturate-induced sleeping time, tail suspension and forced swimming tests in mice. Isopulegol was administered intraperitoneally to male mice at single doses of 25 and 50 mg/kg, while diazepam 1 or 2 mg/kg and imipramine 10 or 30 ...
Tópico(s): Phytochemistry and Biological Activities
2007 - Elsevier BV | Pharmacology Biochemistry and Behavior
Joaquím M. Oliveira, Márcia T. Rodrigues, Simone S. Silva, Patrícia B. Malafaya, Manuela E. Gomes, Carlos Viegas, Isabel R. Dias, Jorge Manuel Teixeira de Azevedo, João F. Mano, Rui L. Reis,
Tópico(s): Silk-based biomaterials and applications
2006 - Elsevier BV | Biomaterials
Produção Nacional
Revisado por pares
Jeferson Falcão do Amaral, Maria Izabel Gomès Silva, Manuel Rufino Aquino de Aquino Neto, Paulo Florentino Teixeira Neto, Brinell Arcanjo Moura, Carla Thiciane Vasconcelos de Melo, Fernando Luiz Oliveira de Araújo, Damião Pergentino de Sousa, Patrícia Freire de Vasconcelos, Silvânia Maria Mendes Vasconcelos, Francisca Cléa Florenço de Sousa,
In the present study were studied the antinociceptives properties of monoterpene R-(+)-limonene (LM) in chemical and thermal models of nociception in mice. The R-(+)-limonene was administered, intraperitoneally (i.p.), at doses of 25 and 50 mg/kg. The results showed significant inhibition produced on chemical nociception induced by intraperitoneal acetic-acid and in the second phase of subplantar formalin test, but did not manifest a significant effect in hot-plate test. The R-(+)-limonene-induced ...
Tópico(s): Pharmacological Effects of Natural Compounds
2007 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Severiano Silva, Maria José Gomes, A. Dias‐da‐Silva, L. F. Gil, Jorge Manuel Teixeira de Azevedo,
The relationship between ultrasound measurements and empty body and carcass chemical composition was investigated. A 500-V real-time ultrasound with a 7.5-MHz probe combined with image analysis was used to make in vivo measurements to predict the empty body and carcass chemical composition of 31 female lambs of two genotypes, ranging in BW from 18.2 to 48.9 kg. Eleven ultrasound measurements of s.c. fat, muscle, and tissue depth were taken at four different sites (over the 13th thoracic vertebra, ...
Tópico(s): Meat and Animal Product Quality
2005 - Oxford University Press | Journal of Animal Science