Thomas Jung, Ivan Milenković, Y. Balcì, Josef Janoušek, Tomáš Kudláček, Zoltán Á. Nagy, B. Baharuddin, J. Bakonyi, Kirk Broders, Santa Olga Cacciola, Ting‐Shou Chang, Nguyen Minh, Tamara Corcobado, Alfredo Cravador, Biljana Đorđević, Álvaro Durán, Manuela Pinheiro Ferreira, Chen Fu, L GARCIA, Ayaka Hieno, H. H. Ho, Chuanxue Hong, Muhammad Junaid, Koji Kageyama, T. Kuswinanti, C. M. B. de F. Maia, Tomáš Májek, Hayato Masuya, G. Magnano di San Lio, Bryan Mendieta-Araica, Nasri Nasri, Leonardo S. S. Oliveira, A. Pane, A. Pérez‐Sierra, Ade Rosmana, Eugenio Sanfuentes, Bruno Scanu, Ritika Singh, Zoran Stanivuković, Marthin Tarigan, Phạm Quang Thu, Ž. Tomić, Michal Tomšovský, Seiji Uematsu, Joan Webber, Huabin Zheng, F.-C. Zheng, C. M. Brasier, Marília Horta Jung,
New species: Phytophthora amamensis T. Jung, K. Kageyama, H. Masuya & S. Uematsu, Phytophthora angustata T. Jung, L. Garcia, B. Mendieta-Araica, & Y. Balci, Phytophthora balkanensis I. Milenković, Ž. Tomić, T. Jung & M. Horta Jung, Phytophthora borneensis T. Jung, A. Durán, M. Tarigan & M. Horta Jung, Phytophthora calidophila T. Jung, Y. Balci, L. Garcia & B. Mendieta-Araica, Phytophthora catenulata T. Jung, T.-T. Chang, N.M. Chi & M. Horta Jung, Phytophthora celeris T. Jung, L. Oliveira, M. Tarigan & I. Milenković, ...
Tópico(s): Botany and Plant Ecology Studies
2024 - Elsevier BV | Studies in Mycology
Manuela Amorim, Hélder Pinheiro, Manuela Pintado,
Establishing of a bio-based and green society makes it possible to take actions to exploit high value resources that can be converted into valuable biological ingredients. Brewer's spent yeast is a natural byproduct from the brewing industry with high biological and nutritional richness. In the present research, the effect of autolysis and subsequent hydrolysis of spent brewer's yeast, using an extract of Cynara cardunculus was investigated by response surface methodology, to define the optimal ...
Tópico(s): Insect Utilization and Effects
2019 - Elsevier BV | LWT
Manuela Amorim, Joana Odila Pereira, David Gomes, Carlos Pereira, Hélder Pinheiro, Manuela Pintado,
Spent brewer's yeast is a natural surplus from brewing industry. In order to up-grade this by-product, isolation of compounds has been tentatively assessed. The main objective of this work focuses on the use of ultrafiltration and nanofiltration pilot system for recovering cell compounds. Initially, yeast was autolyzed and ultrafiltered with a 10 kDa cut-off, and the two fractions obtained were hydrolyzed with Cynara cardunculus extract and nanofiltered with 3 kDa cut-off. Four fractions with different ...
Tópico(s): Consumer Attitudes and Food Labeling
2016 - Elsevier BV | Journal of Food Engineering
Produção Nacional
Revisado por pares
Manuela Amorim, Joana Odila Pereira, Karin Maia Monteiro, Ana Lúcia Tasca Góis Ruiz, João Ernesto de Carvalho, Hélder Pinheiro, Manuela Pintado,
The main objective was to study the antiulcer and antiproliferative potential of yeast peptide extract for further incorporation into functional foods.
Tópico(s): Consumer Attitudes and Food Labeling
2016 - Royal Society of Chemistry | Food & Function
Manuela Amorim, Cláudia Marques, Joana Odila Pereira, L. Guardão, Maria João Martins, Hugo Osório, D. Moura, Conceição Calhau, Hélder Pinheiro, Manuela Pintado,
Numerous studies have investigated dietary approaches to prevent chronic lifestyle-related diseases, including hypertension. Spent brewer’s yeast is the second largest byproduct originated by the brewing industry and it deserves considerable attention because of its high nutritional value, ca. 40% of its dry mass is rich in protein which can be hydrolyzed into biologically active peptides. To upgrade this byproduct, the aim of this study was initially in vitro assessment of biological properties, ...
Tópico(s): Biochemical effects in animals
2018 - Elsevier BV | Process Biochemistry
Marco V. Bernardo, Pedro Fernandes, Ângelo Arrifano, Marc Antonini, Elsa Fonseca, Paulo T. Fiadeiro, António Pinheiro, Manuela Pereira,
Digital holography allows the recording, storage and subsequent reconstruction of both amplitude and phase of the light field scattered by an object. This is accomplished by recording interference patterns that preserve the properties of the original object field essential for 3D visualization, the so-called holograms. Digital holography refers to the acquisition of holograms with a digital sensor, typically a CCD or a CMOS camera, and to the reconstruction of the 3D object field using numerical ...
Tópico(s): Advanced Vision and Imaging
2018 - Elsevier BV | Signal Processing Image Communication
Hosam Alzahrani, Martin Mackey, Emmanuel Stamatakis, Marina B. Pinheiro, Manuela Wicks, Debra Shirley,
To investigate the effectiveness of incidental (non-structured) physical activity interventions for the management of people with low back pain (LBP).Systematic review and meta-analyses of randomised controlled trials.Eligible published trials from the earliest date available to November 2017.People with non-specific LBP aged 18 years or over.Pain, disability and physical activity-related outcomes.Three trials were included (including a total of 422 participants). The quality of trials, assessed by ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2018 - Elsevier BV | Physical Therapy in Sport
Gustavo C Machado, Christopher G. Maher, Paulo H. Ferreira, Richard O. Day, Marina B. Pinheiro, Manuela L. Ferreira,
While it is now clear that paracetamol is ineffective for spinal pain, there is not consensus on the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for this condition. We performed a systematic review with meta-analysis to determine the efficacy and safety of NSAIDs for spinal pain.We searched MEDLINE, EMBASE, CINAHL, CENTRAL and LILACS for randomised controlled trials comparing the efficacy and safety of NSAIDs with placebo for spinal pain. Reviewers extracted data, assessed risk of ...
Tópico(s): Anesthesia and Pain Management
2017 - BMJ | Annals of the Rheumatic Diseases
Marina B. Pinheiro, Manuela L. Ferreira, Kathryn M. Refshauge, Lucía Colodro‐Conde, Francisca González Javier, John L. Hopper, Juan R. Ordoñana, Paulo H. Ferreira,
To investigate whether symptoms of depression increase the risk of low back pain (LBP), after adjusting for genetic and environmental influences.Baseline data of 1607 twins from the Murcia Twin Registry (Spain) were collected in 2009 to 2011 and follow-up data in 2013. Twins answered questions on depression-related symptomatology and LBP. Only participants not reporting chronic LBP (pain >6 mo) at baseline were included. The association between symptoms of depression and LBP was investigated using logistic ...
Tópico(s): Suicide and Self-Harm Studies
2016 - Lippincott Williams & Wilkins | Clinical Journal of Pain
Marina B. Pinheiro, Manuela L. Ferreira, Kathryn M. Refshauge, Christopher G. Maher, Juan R. Ordoñana, Tude B Andrade, Alexandros Tsathas, Paulo H. Ferreira,
Background Context It has been proposed that depression plays an important role in the course of low back pain; however, there is considerable uncertainty on its predictive value. Purpose This systematic review aims to investigate the effect of depression on the course of acute and subacute low back pain. Study Design This is a systematic review. Methods We searched the following databases using optimized search strategies: AMED, CINAHL, EMBASE, Health & Society Database, LILACS, MEDLINE, PsycINFO, ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2015 - Elsevier BV | The Spine Journal
Produção Nacional
Revisado por pares
Marina B. Pinheiro, Manuela L. Ferreira, Kathryn M. Refshauge, Juan R. Ordoñana, Gustavo C Machado, Lucas R. Prado, Christopher G. Maher, Paulo H. Ferreira,
To investigate the contribution of symptoms of depression to future episodes of low back pain (LBP).A search was conducted of AMED, CINAHL, Embase, Health and Society (H&S), LILACS, MEDLINE, PsycINFO, Scopus, and Web of Science databases. We included cohort studies investigating the effect of symptoms of depression on the development of new episodes of LBP, either lifetime incidence or a recurrent episode, in a population free of LBP at baseline. We accepted the original study's definition for a new ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2015 - Wiley | Arthritis Care & Research
Marina B. Pinheiro, Manuela L. Ferreira, Kathryn M. Refshauge, Lucía Colodro‐Conde, Eduvigis Carrillo, John L. Hopper, Juan R. Ordoñana, Paulo H. Ferreira,
In Brief Although the co-occurrence of low back pain (LBP) and depression is common, the nature of this association remains unclear. We aimed to investigate whether symptoms of depression are associated with LBP after adjusting for various confounders, including genetics. We used cross-sectional data from 2148 twins from the Murcia Twin Registry, Spain. All twins answered questions about lifetime prevalence of LBP (outcome variable) and symptoms of depression, collected through two instruments, deriving ...
Tópico(s): Occupational Health and Performance
2015 - Lippincott Williams & Wilkins | Pain
Produção Nacional
Revisado por pares
Rogério Lessa Horta, Bernardo Lessa Horta, Ricardo Tavares Pinheiro, Manuela Krindges,
OBJETIVO: Analisar a associação entre comportamentos violentos de adolescentes e a coabitação parento-filial. MÉTODOS: Estudo transversal de base populacional realizado na área urbana de Pelotas, RS, em 2002, com amostragem em múltiplos estágios. Foram entrevistados 960 adolescentes com utilização de questionário auto-aplicado. As variáveis dependentes (uso de armas e envolvimento em brigas no último ano foram referidos pelos adolescentes) e a variável independente coabitação parento-filial foram ...
Tópico(s): Child Abuse and Trauma
2010 - UNIVERSIDADE DE SÃO PAULO | Revista de Saúde Pública
Simone S. Silva, Antonella Motta, Márcia T. Rodrigues, Ana F. M. Pinheiro, Manuela E. Gomes, João F. Mano, Rui L. Reis, Claudio Migliaresi,
The positive interaction of materials with tissues is an important step in regenerative medicine strategies. Hydrogels that are obtained from polysaccharides and proteins are expected to mimic the natural cartilage environment and thus provide an optimum milleu for tissue growth and regeneration. In this work, novel hydrogels composed of blends of chitosan and Bombyx mori silk fibroin were cross-linked with genipin (G) and were freeze dried to obtain chitosan/silk (CSG) sponges. CSG sponges possess ...
Tópico(s): Antimicrobial Peptides and Activities
2008 - American Chemical Society | Biomacromolecules
Produção Nacional
Revisado por pares
Nayê Balzan Schneider, Tatiane Pastor, André Escremim de Paula, Maria Isabel Achatz, Ândrea Ribeiro‐dos‐Santos, Fernanda Sales Luiz Vianna, Clévia Rosset, Manuela Pinheiro, Patrícia Ashton‐Prolla, María Manuela Martins, Edenir Inêz Palmero,
Abstract Lynch syndrome ( LS ) is the most common hereditary colorectal cancer syndrome, caused by germline mutations in one of the major genes involved in mismatch repair ( MMR ): MLH 1 , MSH 2 , MSH 6 and more rarely, PMS 2 . Recently, germline deletions in EPCAM have been also associated to the syndrome. Most of the pathogenic MMR mutations found in LS families occur in MLH 1 or MSH 2 . Gene variants include missense , nonsense, frameshift mutations, large genomic rearrangements and splice‐site variants and most ...
Tópico(s): Cancer Genomics and Diagnostics
2018 - Wiley | Cancer Medicine
Produção Nacional
Revisado por pares
Ingrid Petroni Ewald, Silvia Liliana Cossio, Edenir Inêz Palmero, Manuela Pinheiro, Ivana Lúcia de Oliveira Nascimento, Taisa Manuela Bonfim Machado, Kiyoko Abe Sandes, Betânia Toralles, Bernardo Garicochea, Patrícia Izetti, Maria Luiza Saraiva Pereira, Hugo Bock, Fernando Regla Vargas, María Manuela Martins, Ana Peixoto, Manuel R. Teixeira, Patrícia Ashton‐Prolla,
Approximately 5-10% of breast cancers are caused by germline mutations in high penetrance predisposition genes. Among these, BRCA1 and BRCA2, which are associated with the Hereditary Breast and Ovarian Cancer (HBOC) syndrome, are the most frequently affected genes. Recent studies confirm that gene rearrangements, especially in BRCA1, are responsible for a significant proportion of mutations in certain populations. In this study we determined the prevalence of BRCA rearrangements in 145 unrelated ...
Tópico(s): Genomic variations and chromosomal abnormalities
2016 - Brazilian Society of Genetics | Genetics and Molecular Biology
Joana G. Guedes, Isabel Veiga, Patrícia Rocha, Pedro Pinto, Carla Pinto, Manuela Pinheiro, Ana Peixoto, Maria Fragoso, A. Raimundo, P. Ferreira, Manuela Machado, Nuno Sousa, Paula Lopes, António Araújo, Joana Martins‐Macedo, Jorge Lino Alves, C. Coutinho, Rui Henrique, Lúcio Lara Santos, Manuel R. Teixeira,
Abstract Background KRAS is an EGFR effector in the RAS/RAF/ERK cascade that is mutated in about 40% of metastatic colorectal cancer (mCRC). Activating mutations in codons 12 and 13 of the KRAS gene are the only established negative predictors of response to anti-EGFR therapy and patients whose tumors harbor such mutations are not candidates for therapy. However, 40 to 60% of wild-type cases do not respond to anti-EGFR therapy, suggesting the involvement of other genes that act downstream of EGFR ...
Tópico(s): Cancer Genomics and Diagnostics
2013 - BioMed Central | BMC Cancer
Joana Savva-Bordalo, João Carvalho, Manuela Pinheiro, Vera L. Costa, Ângelo Rodrigues, Paula C. Dias, Isabel Veiga, Manuela Machado, Manuel R. Teixeira, Rui Henrique, Cármen Jerónimo,
Abstract Background Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene ( DPYD ). Methods In this study, we evaluated DPYD promoter methylation through quantitative methylation-specific PCR and screened DPYD for large intragenic rearrangements in peripheral blood from 45 patients with gastrointestinal cancers who developed severe 5-FU toxicity. DPYD promoter methylation ...
Tópico(s): Gastric Cancer Management and Outcomes
2010 - BioMed Central | BMC Cancer
Manuela Pinheiro, Carla Pinto, Ana Peixoto, Isabel Veiga, Bárbara Mesquita, Rui Henrique, Manuela Baptista, Maria Fragoso, Olga Sousa, Helena Pereira, Carla Marinho, Luís Moreira Dias, Manuel R. Teixeira,
Tópico(s): Colorectal Cancer Screening and Detection
2011 - Elsevier BV | Genetics in Medicine
Produção Nacional
Revisado por pares
Antônio B. Anderson, Hudson T. Pinheiro, Manuela Bernardes Batista, Ronaldo B. Francini‐Filho, L.E.O. Gomes, Ângelo F. Bernardino, Paulo Antunes Horta, J.‐C. Joyeux,
Tópico(s): Marine and coastal plant biology
2022 - Springer Science+Business Media | Biodiversity and Conservation
Carla Pinto, Isabel Veiga, Manuela Pinheiro, Bárbara Mesquita, Cármen Jerónimo, Olga Sousa, Maria Fragoso, Lúcio Lara Santos, Luís Moreira‐Dias, Manuela Baptista, Carlos Lopes, Sérgio Castedo, Manuel R. Teixeira,
Germline MLH1 and MSH2 mutations are scarce in young colorectal cancer patients with negative family history of the disease. To evaluate the contribution of germline MSH6 mutations to early-onset colorectal cancer, we have analysed peripheral blood of 38 patients diagnosed with this disease before 45 years of age and who presented no family history of hereditary nonpolyposis colorectal cancer-related cancers. Blood samples from 108 healthy volunteers were analysed for those genetic alterations suspected ...
Tópico(s): Colorectal Cancer Screening and Detection
2006 - Springer Nature | British Journal of Cancer
Hadi Amirpour, M. Ghanbari, António Pinheiro, Manuela Pereira,
Due to high correlations among the adjacent blocks, several algorithms utilize movement information of spatially and temporally correlated neighbouring blocks to adapt their search patterns to that information. In this paper, this information is used to define a dynamic search pattern. Each frame is divided into two sets, black and white blocks, like a chessboard pattern and a different search pattern is defined for each set. The advantage of this definition is that the number of spatially neighbouring ...
Tópico(s): Video Analysis and Summarization
2019 - Springer Science+Business Media | Multimedia Tools and Applications
Elsa Fonseca, Paulo T. Fiadeiro, Marco V. Bernardo, António Pinheiro, Manuela Pereira,
Digital holography is an emerging imaging technique for displaying and sensing three-dimensional objects. The perceived image quality of a hologram is frequently corrupted by speckle noise due to coherent illumination. Although several speckle noise reduction methods have been developed so far, there are scarce quality assessment studies to address their performance, and they typically focus solely on objective metrics. However, these metrics do not reflect the visual quality perceived by a human ...
Tópico(s): Advanced Optical Imaging Technologies
2019 - Optica Publishing Group | Applied Optics
Produção Nacional
Revisado por pares
André Oliveira Sawakuchi, Eduardo D. Schultz, Fabiano Nascimento Pupim, Dailson José Bertassoli, Daniela Fonseca Melo de Souza, D. F. Cunha, Carlos Eduardo Manjon Mazoca, Manuela Pinheiro Ferreira, Carlos Henrique Grohmann, Ingo Wahnfried, Cristiano Mazur Chiessi, Francisco W. Cruz, Renato Paes de Almeida, Camila C. Ribas,
Spatial arrangement of distinct Amazonian environments through time and its effect on specialized biota remain poorly known, fueling long-lasting debates about drivers of biotic diversification. We address the late Quaternary sediment deposition that assembled the world's largest seasonally flooded ecosystems. Genome sequencing was used to reconstruct the demographic history of bird species specialized in either early successional vegetation or mature floodplain forests. Sediment deposition that ...
Tópico(s): Fish biology, ecology, and behavior
2022 - Nature Portfolio | Nature Communications
Andreia Brandão, Paula Paulo, Sofia Maia, Manuela Pinheiro, Ana Peixoto, Marta Cardoso, María P. Silva, Catarina Santos, Rosalind A. Eeles, Zsofia Kote‐Jarai, Kenneth Muir, Johanna Schleutker, Ying Wang, Nora Pashayan, Jyotsna Batra, Henrik Grönberg, David E. Neal, Børge G. Nordestgaard, Catherine M. Tangen, Melissa C. Southey, Alicja Wolk, Demetrius Albanes, Christopher A. Haiman, Ruth C. Travis, Janet L. Stanford, Lorelei A. Mucci, Catharine West, Sune F. Nielsen, Adam S. Kibel, Olivier Cussenot, Sonja I. Berndt, Stella Koutros, Karina D. Sørensen, Cezary Cybulski, Eli Marie Grindedal, Jong Y. Park, Sue A. Ingles, Christiane Maier, Robert J. Hamilton, Barry S. Rosenstein, Ana Vega, Manolis Kogevinas, Fredrik Wiklund, Kathryn L. Penney, Hermann Brenner, Esther M. John, Radka Kaneva, Christopher J. Logothetis, Susan L. Neuhausen, Kim De Ruyck, Azad Razack, Lisa F. Newcomb, Davor Lessel, Nawaid Usmani, Frank Claessens, Manuela Gago‐Dominguez, Paul A. Townsend, Monique J. Roobol, Manuel R. Teixeira,
The identification of recurrent founder variants in cancer predisposing genes may have important implications for implementing cost-effective targeted genetic screening strategies. In this study, we evaluated the prevalence and relative risk of the
Tópico(s): Ovarian cancer diagnosis and treatment
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Ana Peixoto, Pedro Pinto, Joana Guerra, Manuela Pinheiro, Catarina Santos, Carla Pinto, Rui Santos, Carla Escudeiro, Carla Bartosch, R. Canário, Ana Paula Fernandes Barbosa, Alfredo Gouveia, Almerinda Petiz, Miguel Henriques Abreu, Susana Sousa, Deolinda Pereira, João Silva, Manuel R. Teixeira,
Deleterious variants in the BRCA1/BRCA2 genes and homologous recombination deficiency (HRD) status are considered strong predictors of response to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi). The introduction of PARPi in clinical practice for the treatment of patients with advanced ovarian cancer imposed changes in the molecular diagnosis of BRCA1/BRCA2 variants. BRCA1/BRCA2 tumor testing by next-generation sequencing (NGS) can detect simultaneously both somatic and germline variants, allowing ...
Tópico(s): CRISPR and Genetic Engineering
2020 - Frontiers Media | Frontiers in Oncology
Pedro Pinheiro‐Chagas, Manuela Piazza, Stanislas Dehaene,
Elementary arithmetic is highly prevalent in our daily lives. However, despite decades of research, we are only beginning to understand how the brain solves simple calculations. Here, we applied machine learning techniques to magnetoencephalography (MEG) signals in an effort to decompose the successive processing stages and mental transformations underlying elementary arithmetic. Adults subjects verified single-digit addition and subtraction problems such as 3 + 2 = 9 in which each successive symbol ...
Tópico(s): Neuroscience and Music Perception
2018 - Elsevier BV | Cortex
Ana Paula Fernandes Barbosa, Ana Peixoto, Pedro Pinto, Manuela Pinheiro, Manuel R. Teixeira,
Abstract Circulating cell-free DNA (cfDNA) consists of small fragments of DNA that circulate freely in the bloodstream. In cancer patients, a fraction of cfDNA is derived from tumour cells, therefore containing the same genetic and epigenetic alterations, and is termed circulating cell-free tumour DNA. The potential use of cfDNA, the so-called ‘liquid biopsy’, as a non-invasive cancer biomarker has recently received a lot of attention. The present review will focus on studies concerning the potential ...
Tópico(s): Renal cell carcinoma treatment
2018 - Cambridge University Press | Expert Reviews in Molecular Medicine
Diana Pinto, Carla Pinto, Joana Guerra, Manuela Pinheiro, Rui Santos, Hege Marie Vedeld, Zeremariam Yohannes, Ana Peixoto, Catarina Santos, Pedro Pinto, Paula Lopes, Ragnhild A. Lothe, Guro E. Lind, Rui Henrique, Manuel R. Teixeira,
Constitutional epimutation of the two major mismatch repair genes, MLH1 and MSH2, has been identified as an alternative mechanism that predisposes to the development of Lynch syndrome. In the present work, we aimed to investigate the prevalence of MLH1 constitutional methylation in colorectal cancer (CRC) patients with abnormal expression of the MLH1 protein in their tumors. In a series of 38 patients who met clinical criteria for Lynch syndrome genetic testing, with loss of MLH1 expression in the ...
Tópico(s): Cancer Genomics and Diagnostics
2018 - Wiley | Cancer Medicine
Joana Guerra, Carla Pinto, Diana Pinto, Manuela Pinheiro, Romina Silva, Ana Peixoto, Patrícia Rocha, Isabel Veiga, Catarina Santos, Rui Santos, Verónica Cabreira, Paula Lopes, Rui Henrique, Manuel R. Teixeira,
Abstract Despite all the knowledge already gathered, the picture of somatic genetic changes in colorectal tumorigenesis is far from complete. Recently, germline and somatic mutations in the exonuclease domain of polymerase epsilon, catalytic subunit ( POLE ) gene have been reported in a small subset of microsatellite‐stable and hypermutated colorectal carcinomas ( CRC s), affecting the proofreading activity of the enzyme and leading to misincorporation of bases during DNA replication. To evaluate the ...
Tópico(s): Colorectal Cancer Treatments and Studies
2017 - Wiley | Cancer Medicine