Fabrizio De Benedetti, Jordi Antón, M. Gattorno, Helen Lachmann, I. Kone-Paut, Seza Özen, Joost Frenkel, A. Simon, Andrew Zeft, E. Ben-Chetrit, Hal M. Hoffman, Y. Joubert, K. Lheritier, A. Speziale, J. Guido, Roberta Caorsi, Federica Penco, Alice Grossi, Antonella Insalaco, Maria Alessio, Giovanni Conti, Federico Marchetti, Alberto Tommasini, Silvana Martino, Romina Gallizzi, Annalisa Salis, Francesca Schena, Francesco Caroli, Alberto Martini, Gianluca Damonte, Isabella Ceccherini, Marco Gattorno, Marie‐Louise Frémond, Carolina Uggenti, Lien Van Eyck, Isabelle Melki, Darragh Duffy, Vincent Bondet, Yoann Rose, Bénédicte Neven, Yanick J. Crow, Mathieu P. Rodero, Yvonne Kusche, Johannes Roth, Katarzyna Barczyk‐Kahlert, Giovanna Ferrara, Annalisa Chiocchetti, Silvio Polizzi, Josef Vuch, Diego Vozzi, Anna Mondino, Erica Valencic, Serena Pastore, Andrea Taddio, Flavio Faletra, Umberto Dianzani, Ugo Ramenghi, Alberto Tommasini, Qing Zhou, Xiaomin Yu, Erkan Demirkaya, Natalie Deuitch, Deborah L. Stone, Wanxia Li Tsai, Amanda K. Ombrello, Tina Romeo, Elaine F. Remmers, JaeJin Chae, Massimo Gadina, Steven B. Welch, Seza Özen, Rezan Topaloğlu, Mario Abinun, Daniel L. Kastner, Ivona Aksentijevich, Donatella Vairo, Rosalba Monica Ferraro, Giulia Zani, Jessica Galli, Micaela De Simone, Marco Cattalini, Elisa Fazzi, Silvia Giliani, Ebun Omoyinmi, Ariane Standing, Dorota Rowczenio, Annette Keylock, Sónia Gomes, Fiona Price-Kuehne, Sira Nanthapisal, Claire Murphy, Thomas Cullup, Lucy Jenkins, Kimberly Gilmour, Despina Eleftheriou, Helen Lachmann, Philip N. Hawkins, Nigel Klein, Paul Brogan, Anita Dhanrajani, Mercedes Chan, Stephanie Pau, Janet Ellsworth, Jaime Guzmán, Florence A. Aeschlimann, Marinka Twilt, Simon Eng, Shehla Sheikh, Ronald M. Laxer, Diane Hébert, Damien Noone, Christian Pagnoux, Susanne M. Benseler, Rae S. M. Yeung, Christoph Kessel, Katrin Lippitz, Toni Weinhage, Claas Hinze, Helmut Wittkowski, Dirk Holzinger, N.G. Grün, Dirk Föll, Pieter van Dijkhuizen, Federica Del Chierico, Clara Malattia, Alessandra Russo, Denise Pires Marafon, Nienke M. ter Haar, Silvia Magni‐Manzoni, Sebastiaan J. Vastert, Bruno Dallapiccola, Berent Prakken, Alberto Martini, Fabrizio De Benedetti, Lorenza Putignani, Berna Eren Fidancı, Kenan Barut, Serap Arıcı, Doğan ŞİMŞEK, Mustafa Çakan, Ezgi Deniz Batu, Sezgin Şahin, Ayşenur Kısaarslan, Ebru Yılmaz, Özge Başaran, Ferhat Demir, Kubra Ozturk, Zübeyde Gunduz, Betül Sözeri, Balahan Makay, Nuray Aktay Ayaz, Önder Yavaşcan, Özlem Aydoğ, Yelda Bilginer, Zelal Ekinci, Dilek Yıldız, Faysal Gök, Müferret Ergüven, Erbil Unsal, Özgür Kasapçopur, Seza Özen, Erkan Demirkaya, Hafize Emine Sönmez, Ezgi Deniz Batu, Betül Sözeri, Yonatan Butbul, Yelda Bilginer, Seza Özen, Claudia Bracaglia, Giusi Prencipe, Manuela Pardeo, G Lapeyre, Emiliano Marasco, Antonella Insalaco, Walter G. Ferlin, Robert D. Nelson, Cristina de Min, Fabrizio De Benedetti, Nicolino Ruperto, Hermine I. Brunner, Pierre Quartier, T. Constantin, E. Alexeeva, Isabelle Koné‐Paut, K. Marzan, Nico Wulffraat, R. Schneider, Shai Padeh, V. Chasnyk, C. Wouters, J. B. Kuemmerle‐Deschner, T. Kallinich, Bernard Lauwerys, E. Haddad, E. Nasonov, M. Trachana, Olga Vougiouka, K. Leon, E. Vritzali, K. Lheritier, Alberto Martini, Daniel J. Lovell, Francesca Schena, Stefano Volpi, Roberta Caorsi, Federica Penco, Claudia Pastorino, Francesca Kalli, Alessia Omenetti, Sabrina Chiesa, Arinna Bertoni, Paolo Picco, Gilberto Filaci, Ivona Aksentijevich, Alice Grossi, Isabella Ceccherini, Alberto Martini, Elisabetta Traggiai, Marco Gattorno, Isabelle Melki, Yoann Rose, Carolina Uggenti, Marie‐Louise Frémond, Lien Van Eyck, Naoki Kitabayashi, Marco Gattorno, Stefano Volpi, Oliviero Sacco, Isabelle Meyts, Marie‐Anne Morren, Carine Wouters, Eric Legius, Isabelle Callebaut, Christine Bodemer, Frédéric Rieux‐Laucat, Mathieu P. Rodero, Yanick J. Crow, Marie‐Louise Frémond, Mathieu P. Rodero, Nadia Jeremiah, Alexandre Bélot, Éric Jeziorski, Darragh Duffy, D. Bessis, Guilhem Cros, Gillian Rice, Bruno Charbit, Anne Hulin, Nihel Khoudour, Consuelo Modesto Caballero, Christine Bodemer, Monique Fabrè, Laureline Berteloot, Muriel Le Bourgeois, Philippe Reix, Thierry Walzer, Despina Moshous, Stéphane Blanche, Alain Fischer, Brigitte Bader‐Meunier, Frédéric Rieux‐Laucat, Yanick J. Crow, Bénédicte Neven, Kim V. Annink, Nienke M. ter Haar, Sulaiman M. Al‐Mayouf, Gayane Amaryan, Jordi Antón, KS Barron, Susanne M. Benseler, Paul Brogan, L. Cantarini, Marco Cattalini, Alexis Virgil Cochino, Fabrizio De Benedetti, F. Dedeoglu, A. De Jesus, O. Dellacasa, Erkan Demirkaya, Pavla Doležalová, K. Durrant, Fabio Gavarini, Romina Gallizzi, Raphaela Goldbach‐Mansky, E. Hachulla, Véronique Hentgen, Troels Herlin, M. Hofer, H. Hoffman, Antonella Insalaco, Annette Jansson, T. Kallinich, Isabelle Koné‐Paut, Anastasiia Kozlova, Jasmin Kuemmerle‐Deschner, Helen Lachmann,
Introduction: Gain-of-function mutations in TMEM173 encoding STING (Stimulator of Interferon Genes) underlie a novel type I interferonopathy, minimally responsive to conventional immunosuppressive therapies and associated with high childhood morbidity and mortality.A newly emerging treatment strategy in STING-related inflammation aims to control interferon (IFN) signalling post-binding of the IFN receptor, by targeting JAK1/2.We hypothesized that inhibition of IFN production itself might represent ...
BioMed Central
David Riddell, Dimitri V. Vinogradov, Anita K. Stannard, Nicholas Chadwick, James S. Owen,
... 3′) described elsewhere (9Kim D.H. Magoori K. Inoue T.R. Mao C.C. Kim H.J. Suzuki H. Fujita ... the cytoplasmic insert (9Kim D.H. Magoori K. Inoue T.R. Mao C.C. Kim H.J. Suzuki H. Fujita ... As previously reported (9Kim D.H. Magoori K. Inoue T.R. Mao C.C. Kim H.J. Suzuki H. Fujita ... with equal affinity (9Kim D.H. Magoori K. Inoue T.R. Mao C.C. Kim H.J. Suzuki H. Fujita ...
Tópico(s): Cellular transport and secretion
1999 - Elsevier BV | Journal of Lipid Research
Yonghe Li, Wenyan Lü, María‐Paz Marzolo, Guojun Bu,
... of the genes (41Kim D.H. Magoori K. Inoue T.R. Mao C.C. Kim H.J. Suzuki H. Fujita ... of the genes (41Kim D.H. Magoori K. Inoue T.R. Mao C.C. Kim H.J. Suzuki H. Fujita ... of the genes (41Kim D.H. Magoori K. Inoue T.R. Mao C.C. Kim H.J. Suzuki H. Fujita ...
Tópico(s): Retinal Diseases and Treatments
2001 - Elsevier BV | Journal of Biological Chemistry
Christian Brandes, Larissa Kahr, Walter Stockinger, Thomas Hiesberger, Wolfgang J. Schneider, Johannes Nimpf,
... 350) Google Scholar, 7Kim D.-H. Magoori K. Inoue T.R. Mao C.C. Kim H.-J. Suzuki H. Fujita ... brain as well (7Kim D.-H. Magoori K. Inoue T.R. Mao C.C. Kim H.-J. Suzuki H. Fujita ... for human ApoER2 (7Kim D.-H. Magoori K. Inoue T.R. Mao C.C. Kim H.-J. Suzuki H. Fujita ...
Tópico(s): Signaling Pathways in Disease
2001 - Elsevier BV | Journal of Biological Chemistry
Masaki Shimizu, Yasuo Nakagishi, Natsumi Inoue, Mao Mizuta, Giyo Ko, Yutaka Saikawa, Tomohiro Kubota, Yuichi Yamasaki, Syuji Takei, Akihiro Yachie,
To assess the role of IL-6/IL-18 in the pathogenesis of systemic juvenile idiopathic arthritis (s-JIA) and to investigate the clinical significance of serum IL-18 levels for predicting macrophage activation syndrome (MAS) development, we measured the serum IL-6/IL-18 levels in 76s-JIA patients, including 15 with MAS, and compared them with the clinical features. We identified 2 distinct subsets on the basis of serum IL-6/IL-18 levels. The IL-18-dominant subset had more patients who developed MAS. ...
Tópico(s): Kawasaki Disease and Coronary Complications
2015 - Elsevier BV | Clinical Immunology
Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yoshinori Nakagishi, Akihiro Yachie,
Summary To investigate the clinical significance of soluble tumour necrosis factor receptor (sTNF-R) II/I ratio as an indicator of the diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s-JIA), we measured the serum sTNF-RI and II levels in 117 patients with s-JIA, including 29 patients with MAS, 15 with Epstein–Barr virus-induced haemophagocytic lymphohistiocytosis (EBV-HLH), 15 with Kawasaki disease (KD) and 28 healthy controls (HCs). We determined ...
Tópico(s): Immune Cell Function and Interaction
2017 - Oxford University Press | Clinical & Experimental Immunology
Naoki Inoue, Mao Abe, Ryo Kobayashi, Souichi Yamada,
The development of a cytomegalovirus (CMV) vaccine has become a top priority due to its potential cost-effectiveness and associated public health benefits. However, there are a number of challenges facing vaccine development including the following: (1) CMV has many mechanisms for evading immune responses , and natural immunity is not perfect, (2) the immune correlates for protection are unclear, (3) a narrow range of CMV hosts limits the value of animal models, and (4) the placenta is a specialized organ ...
Tópico(s): Toxoplasma gondii Research Studies
2018 - Springer Nature | Advances in experimental medicine and biology
Asumi Jinkawa, Masaki Shimizu, Keigo Nishida, Shuya Kaneko, M Usami, Naoto Sakumura, Hitoshi Irabu, Maiko Takakuwa, Natsumi Inoue, Mao Mizuta, Yasuhiro Ikawa, Shuhei Fujita, Akihiro Yachie,
The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sTNFR-II levels were determined using enzyme-linked immunosorbent assay in 78 patients with KD, including five with MAS. Results were compared to the clinical features of MAS. Serum neopterin, ...
Tópico(s): Mechanical Circulatory Support Devices
2019 - Elsevier BV | Cytokine
Maiko Takakura, Masaki Shimizu, Hitoshi Irabu, Naoto Sakumura, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie,
Our study aimed to compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s-JIA). Serum cytokine levels (neopterin, IL-18, and CXCL9 and soluble tumor necrosis factor receptor type I (sTNFR-I) and II) were determined by enzyme-linked immunosorbent assay in 78 patients with s-JIA, including 21 with MAS. Receiver operating characteristic curve analysis revealed area under the curve values and cut off values ...
Tópico(s): Adolescent and Pediatric Healthcare
2019 - Elsevier BV | Clinical Immunology
Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie,
To investigate whether serum leucine-rich α 2-glycoprotein (LRG) levels are useful as a marker of disease activity in systemic juvenile idiopathic arthritis (s-JIA), we determined serum LRG levels in fifty-nine s-JIA patients, 15 with other subtypes of JIA, 7 with Kawasaki disease (KD), 7 with influenza A infection (flu), 7 with enterohemorrhagic Escherichia coli (EHEC) infection, and 20 healthy controls (HC). Results were compared with the clinical features of s-JIA and serum cytokine levels including ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2019 - Hindawi Publishing Corporation | Journal of Immunology Research
Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuhiro Ikawa, Akihiro Yachie,
Tópico(s): Multiple Myeloma Research and Treatments
2016 - Oxford University Press | Lara D. Veeken
Masaki Shimizu, Yasuo Nakagishi, Natsumi Inoue, Mao Mizuta, Akihiro Yachie,
To assess the role of leucine-rich α2-glycoprotein (LRG) as a biomarker for monitoring systemic juvenile idiopathic arthritis (s-JIA) disease activity during interleukin (IL)-6 blockade treatment.We serially measured serum LRG levels in four s-JIA patients treated with the anti-IL-6 receptor antibody tocilizumab and determined the correlation between clinical symptoms and other inflammatory biomarkers and proinflammatory cytokines, including IL-18, IL-6, neopterin, and tumor necrosis factor-α receptor ...
Tópico(s): Clusterin in disease pathology
2017 - Oxford University Press | Modern Rheumatology
Masaru Shimizu, Toshihito Mihara, Junya Ohara, Keita Inoue, Mao Kinoshita, Teiji Sawa,
Staphylococcus aureus is the primary cause of bacteremia, and methicillin-resistant S . aureus bacteremia is associated with a high mortality rate. Methicillin-resistant S . aureus clones are widespread worldwide, and molecular epidemiological studies are important. Therefore, this study aimed to determine the characteristics of patients who died due to methicillin-resistant S . aureus bacteremia and microbiological characteristics of methicillin-resistant S . aureus strains in a tertiary teaching hospital. ...
Tópico(s): Bacterial biofilms and quorum sensing
2022 - Public Library of Science | PLoS ONE
Yoh Inoue, Hongwei Mao, Steven B. Suway, Josue Orellana, Andrew B. Schwartz,
Neural prostheses decode intention from cortical activity to restore upper extremity movement. Typical decoding algorithms extract velocity-a vector quantity with direction and magnitude (speed) -from neuronal firing rates. Standard decoding algorithms accurately recover arm direction, but the extraction of speed has proven more difficult. We show that this difficulty is due to the way speed is encoded by individual neurons and demonstrate how standard encoding-decoding procedures produce characteristic ...
Tópico(s): Muscle activation and electromyography studies
2018 - Nature Portfolio | Nature Communications
Tomohiko Taguchi, Ken Kitajima, Sadako Inoue, Yasuo Inoue, Ji-Mao Yang, Harry Schachter, Inka Brockhausen,
UDP-GlcNAc:GlcNAcβ1→(GlcNAcβ1→2) Manα1→R[GlcNAc to Man]β1→4N-acetylglucosaminyltransferase VI (GnT VI) activity was shown to be present in crude homogenates of Medaka fish (Oryzias latipes) ovaries using UDP-[14C]GlcNAc and synthetic GlcNAc β1→6 (GlcNAcβ1→2)Manα1→6Glcβ1→octyl as substrates. Characterization of this activity showed a pH optimum at about pH 7.0 and an absolute requirement for divalent cations. The optimum concentration of Mn2+was at about 25 mM. This finding is the first report on GnT ...
Tópico(s): Carbohydrate Chemistry and Synthesis
1997 - Elsevier BV | Biochemical and Biophysical Research Communications
Hitoshi Irabu, Masaki Shimizu, Shuya Kaneko, Natsumi Inoue, Mao Mizuta, Yuko Tasaki, Kazuhide Ohta, Akihiro Yachie, Taizo Wada,
Tópico(s): Inflammasome and immune disorders
2020 - Springer Nature | Pediatric Research
Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuhisa Sakakibara, Yasuhito Hamaguchi, Akihiro Yachie,
Shimizu, Masaki MD, PhD; Inoue, Natsumi; Mizuta, Mao; Sakakibara, Yasuhisa; Hamaguchi, Yasuhito; Yachie, Akihiro Author Information
Tópico(s): Soft tissue tumor case studies
2018 - Lippincott Williams & Wilkins | JCR Journal of Clinical Rheumatology
Hitoshi Irabu, Masaki Shimizu, Shuya Kaneko, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie,
Tópico(s): Adolescent and Pediatric Healthcare
2020 - Springer Nature | Pediatric Research
Dong-Ho Kim, Kenta Magoori, Takashi Inoue, Chang C. Mao, Hyoun-Ju Kim, Hiroyuki Suzuki, Teizo Fujita, Yuichi Endo, Shigeru Saeki, Tokuo Yamamoto,
Apolipoprotein E receptor 2 is a recently identified receptor that resembles low and very low density lipoprotein receptors. Isolation and characterization of genomic clones encoding human apolipoprotein E receptor 2 revealed that the gene spans ~60 kilobases and contains 19 exons. The positions of the exon/intron boundaries of the gene are almost identical to those of low and very low density lipoprotein receptors. Fluorescent in situ hybridization of human chromosomes revealed that the gene is ...
Tópico(s): Advanced biosensing and bioanalysis techniques
1997 - Elsevier BV | Journal of Biological Chemistry
Toshihito Mihara, Takeshi Kimura, Kyoko Momiyama, Atsushi Kainuma, Koichi Akiyama, Junya Ohara, Keita Inoue, Mao Kinoshita, Masaru Shimizu, Kiyoshi Moriyama, Naohisa Fujita, Teiji Sawa,
The secondary in-hospital epidemiological investigation for drug-resistant Pseudomonas aeruginosa infections was conducted to evaluate the in-hospital situation and identify any associations between exoenzyme genotypes and other genotypes and antimicrobial resistance characteristics, at the University Hospital in Kyoto, Japan, following a reported outbreak of antimicrobial-resistant P. aeruginosa ST357 between 2005 and 2014. Twelve of the 546 P. aeruginosa isolates collected during the follow-up ...
Tópico(s): Antibiotic Use and Resistance
2019 - Elsevier BV | Journal of Infection and Chemotherapy
Hitoshi Irabu, Masaki Shimizu, Shuya Kaneko, Natsumi Inoue, Mao Mizuta, Kazuhide Ohta, Akihiro Yachie,
This study was aimed at investigating the clinical significance of serum galactose-deficient IgA1 (Gd-IgA1) levels measured by a novel lectin-independent enzyme-linked immunosorbent assay (ELISA) using an anti-Gd-IgA1 monoclonal antibody (KM55) as a disease-specific biomarker for IgA nephropathy (IgAN) in children. Thirty-three children with IgAN, 40 with non-IgA glomerular diseases, and 38 age-matched healthy controls (HCs) were enrolled. Serum Gd-IgA1 levels were quantified by ELISA using KM55. Results ...
Tópico(s): Blood groups and transfusion
2020 - Hindawi Publishing Corporation | Journal of Immunology Research
Atsushi Kainuma, Kyoko Momiyama, Takeshi Kimura, Koichi Akiyama, Keita Inoue, Yoshifumi Naito, Mao Kinoshita, Masaru Shimizu, Hideya Kato, Nobuaki Shime, Naohisa Fujita, Teiji Sawa,
Antimicrobial-resistant isolates of Pseudomonas aeruginosa collected from 2005 to 2014 in a university hospital in Kyoto, Japan, were retrospectively analyzed by multilocus sequence typing (MLST), exoenzyme genotype determination, integron characterization, and clinical associations. During the study, 1573 P. aeruginosa isolates were detected, and 41 of these were resistant to more than two classes of antimicrobial agents. Twenty-five (61.0%) isolates were collected from urine. All isolates were resistant ...
Tópico(s): Bacterial biofilms and quorum sensing
2018 - Elsevier BV | Journal of Infection and Chemotherapy
Kei Inoue, Tomoyuki Mao, Hidetoshi Okutomi, Ken Umeno,
Abstract The Lyapunov exponent is used to quantify the chaos of a dynamical system, by characterizing the exponential sensitivity of an initial point on the dynamical system. However, we cannot directly compute the Lyapunov exponent for a dynamical system without its dynamical equation, although some estimation methods do exist. Information dynamics introduces the entropic chaos degree to measure the strength of chaos of the dynamical system. The entropic chaos degree can be used to compute the ...
Tópico(s): Complex Systems and Time Series Analysis
2021 - Springer Science+Business Media | Japan Journal of Industrial and Applied Mathematics
Toshihiro Takami, Kenji Ohata, Naohiro Tsuyuguchi, Ying Mao, Yuichi Inoue, Kenichi Wakasa, Mitsuhiro Hara,
Abstract We report here an extremely rare case of cavernous sinus metastasis from thyroid papillary adenocarcinoma presenting long after initial diagnosis. A 41-year-old patient presented with a cavernous sinus tumor causing progressive diplopia 10 years after treatment for a papillary adenocarcinoma of the thyroid. After 5 years of close observation, subarachnoid hemorrhage developed from the cavernous sinus tumor extending to the cerebellopontine angle, at which point the patient underwent surgical removal ...
Tópico(s): Head and Neck Anomalies
2002 - Elsevier BV | Journal of Clinical Neuroscience
Xuesong Mao, Daisuke Inoue, Satoru Kato, Manabu Kagami,
Doppler laser radar can improve the precision of speed measurement by about two orders of magnitude compared with time-of-flight range finders, which obtain target speeds by range differentiation. However, in a car environment, the usage of traditional Doppler laser radar schemes is limited, because they do not satisfy the requirement of simultaneously measuring the target range together with speed with high precision. First, in this paper, we describe a new in-car laser radar system and show a ...
Tópico(s): Ocular and Laser Science Research
2011 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Intelligent Transportation Systems
Lili Mao, Koichi Inoue, Yisong Tao, G.T. Montelione, Ann E. McDermott, Masayori Inouye,
Tópico(s): RNA and protein synthesis mechanisms
2011 - Springer Science+Business Media | Journal of Biomolecular NMR
Xuesong Mao, Daisuke Inoue, Hiroyuki Matsubara, Manabu Kagami,
Laser radar provides better spatial resolution than millimeter-wave radar (MWR) due to the high directivity of the laser beam. However, commercial in-car laser radar approximates the target speed by a range differentiation method, which has the problems of excessive time consumption and the introduction of large errors. In this paper, a new Doppler laser radar scheme for simultaneously measuring target range and speed in automotive applications is presented. The scheme includes a new laser radar ...
Tópico(s): Ocular and Laser Science Research
2012 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Intelligent Transportation Systems
Jung‐Fu Lin, E. Ercan, Zhu Mao, Toru Inoue, Catherine McCammon, Yuming Xiao, Paul Chow, J. Zhao,
The electronic spin and valence states of iron in lower-mantle silicate perovskite have been previously investigated at high pressures using various experimental and theoretical techniques. However, experimental results and their interpretation remain highly debated. Here we have studied a wellcharacterized silicate perovskite starting sample [(Mg0.9,Fe0.1)SiO3] in a chemically inert Ne pressure medium at pressures up to 120 GPa using synchrotron Mössbauer spectra. Analyses of the Mössbauer spectra ...
Tópico(s): Geological and Geochemical Analysis
2012 - Mineralogical Society of America | American Mineralogist
Makiko Fukaya, Yoshiaki Tamura, Yuko Chiba, Toshihiro Tanioka, Ji Mao, Yoko Inoue, Marina Yamada, Christian Waeber, Yukari Ido-Kitamura, Tadahiro Kitamura, Masao Kaneki,
Nicotinamide rescues β-cell damage and diabetes in rodents, but a large-scale clinical trial failed to show the benefit of nicotinamide in the prevention of type 1 diabetes. Recent studies have shown that Sirt1 deacetylase, a putative protector of β-cells, is inhibited by nicotinamide. We investigated the effects of isonicotinamide, which is a derivative of nicotinamide and does not inhibit Sirt1, on streptozotocin (STZ)-induced diabetes in mice. Male C57BL/6 mice were administered with three different ...
Tópico(s): PARP inhibition in cancer therapy
2013 - Elsevier BV | Biochemical and Biophysical Research Communications
Nadia O. Abutaleb, George A. Truskey,
... Fukunishi T. Bedja D. Suresh A. Chen T. Inoue T. Dietz H.C. Santhanam L. Mao H.Q. et al.Regenerative and durable small- ...
Tópico(s): 3D Printing in Biomedical Research
2020 - Elsevier BV | Cell stem cell