Daniel Luque, Irene Saugar, María Teresa Rejas, José L. Carrascosa, José F. Rodrígúez, José R. Castón,
Genome-binding proteins with scaffolding and/or regulatory functions are common in living organisms and include histones in eukaryotic cells, histone-like proteins in some double-stranded DNA (dsDNA) viruses, and the nucleocapsid proteins of single-stranded RNA viruses. dsRNA viruses nevertheless lack these ribonucleoprotein (RNP) complexes and are characterized by sharing an icosahedral T = 2 core involved in the metabolism and insulation of the dsRNA genome. The birnaviruses, with a bipartite dsRNA ...
Tópico(s): Viral Infections and Vectors
2008 - Elsevier BV | Journal of Molecular Biology
Santiago Vidal, Ahmed El Motiam, Rocío Seoane, Viktorija Preitakaitė, Yanis Hichem Bouzaher, Sergio Gómez‐Medina, Carmen San Martı́n, Dolores Rodrı́guez, María Teresa Rejas, Maite Baz-Martínez, Rosa Barrio, James D. Sutherland, Manuel S. Rodríguez, César Muñoz‐Fontela, Carmen Rivas,
The Ebola virus VP24 protein plays a critical role in escape of the virus from the host innate immune response. Therefore, deciphering the molecular mechanisms modulating VP24 activity may be useful to identify potential targets amenable to therapeutics. Here, we identify the cellular proteins USP7, SUMO, and ubiquitin as novel interactors and regulators of VP24. These interactions may represent novel potential targets to design new antivirals with the ability to modulate Ebola virus replication.
Tópico(s): Hepatitis B Virus Studies
2019 - American Society for Microbiology | Journal of Virology
Alfonso Oyarzábal, Irene Bravo‐Alonso, María Sánchez‐Aragó, María Teresa Rejas, B. Merinero, Àngels García‐Cazorla, Rafael Artuch, Magdalena Ugarte, Pilar Rodríguez‐Pombo,
Mutations on the mitochondrial-expressed Branched Chain α-Keto acid Dehydrogenase Kinase (BCKDK) gene have been recently associated with a novel dietary-treatable form of autism. But, being a mitochondrial metabolism disease, little is known about the impact on mitochondrial performance. Here, we analyze the mitochondrial response to the BCKDK-deficiency in patient's primary fibroblasts by measuring bioenergetics, ultra-structural and dynamic parameters. A two-fold increase in superoxide anion production, ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2016 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Irene Bravo‐Alonso, Alfonso Oyarzábal, María Sánchez‐Aragó, María Teresa Rejas, B. Merinero, Àngels García‐Cazorla, Rafael Artuch, Magdalena Ugarte, Pilar Rodríguez‐Pombo,
This data article contains complementary figures to the research article "Mitochondrial response to the BCKDK-deficiency: some clues to understand the positive dietary response in this form of autism" [1]. Herein we present data relative to the effect of knocking down BCKDK gene on the real time oxygen consumption rate of fibroblasts obtained from a Maple Syrup Urine Disease (MSUD) patient. Interference of BCKDK expression on such cells showing a reduced branched-chain α-ketoacid dehydrogenase (BCKDHc) ...
Tópico(s): Metabolism and Genetic Disorders
2016 - Elsevier BV | Data in Brief
Uxía Gurriarán‐Rodríguez, Kasun Kodippili, David Datzkiw, Ehsan Javandoost, Fan Xiao, María Teresa Rejas, Michael A. Rudnicki,
Intramuscular injection of Wnt7a has been shown to accelerate and augment skeletal muscle regeneration and to ameliorate dystrophic progression in mdx muscle, a model for Duchenne muscular dystrophy (DMD). Here, we assessed muscle regeneration and function in wild type (WT) and mdx mice where Wnt7a was deleted in muscle using a conditional Wnt7a floxed allele and a Myf5-Cre driver. We found that both WT and mdx mice lacking Wnt7a in muscle, exhibited marked deficiencies in muscle regeneration at 21 ...
Tópico(s): Cardiovascular Effects of Exercise
2024 - BioMed Central | Skeletal Muscle
... Priego de Córdoba, 2015, pp. 317-330.Canabal Rodríguez, L., “Clausura en el siglo XVII: el convento dominicano de Jesús y María en Toledo”, Toletana. Cuestiones de Teología e Historia, 14 (2006) pp. 137-160.Canabal Rodríguez, L., “Las comunidades religiosas femeninas de Toledo. Implantación ...
Tópico(s): Historical Studies in Latin America
2019 - University of Castile-La Mancha | Vínculos de Historia Revista del Departamento de Historia de la Universidad de Castilla-La Mancha