Harald Unterweger, Christina Janko, Marc Schwarz, László Dézsi, Rudolf Urbanics, Jasmin Matuszak, Erik Őrfi, Tamás Fülöp, Tobias Bäuerle, János Szebeni, Clément Journé, Aldo R. Boccaccını, Christoph Alexiou, Stefan Lyer, Iwona Cicha,
Abstract: Iron oxide-based contrast agents have been in clinical use for magnetic resonance imaging (MRI) of lymph nodes, liver, intestines, and the cardiovascular system. Superparamagnetic iron oxide nanoparticles (SPIONs) have high potential as a contrast agent for MRI, but no intravenous iron oxide-containing agents are currently approved for clinical imaging. The aim of our work was to analyze the hemocompatibility and immuno-safety of a new type of dextran-coated SPIONs (SPIONdex) and to characterize ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2017 - Dove Medical Press | International Journal of Nanomedicine
Joël LeMaoult, John S. Manavalan, Ruben Dyall, Paul Szabo, Janko Nikolić‐Žugić, Marc E. Weksler,
Previous studies from this laboratory have shown that >85% of old mice have stable B cell clonal populations detectable by Ig heavy chain complementary-determining region 3 mRNA size analysis and confirmed by sequence analysis. B cells from the same clone are frequently detected in several lymphoid compartments of the same mouse. We now report the phenotype of all ten stable B cell clonal populations detected in five 20-month-old C57BL/6 mice. These clonal B cells appear to develop in the periphery ...
Tópico(s): Immune Cell Function and Interaction
1999 - American Association of Immunologists | The Journal of Immunology
Janneke D. M. Verberk, Marieke L. A. de Hoog, Ilse Westerhof, S. van Goethem, Christine Lammens, Greet Ieven, Erwin de Bruin, Dirk Eggink, Julia Bielicki, Samuel Coenen, Janko van Beek, Marc J. M. Bonten, Herman Goossens, Patricia Bruijning‐Verhagen,
Household transmission studies are useful to quantify SARS-CoV-2 transmission dynamics. We conducted a remote prospective household study to quantify transmission, and the effects of subject characteristics, household characteristics, and implemented infection control measures on transmission. Households with a laboratory-confirmed SARS-CoV-2 index case were enrolled < 48 h following test result. Follow-up included digitally daily symptom recording, regular nose-throat self-sampling and paired dried ...
Tópico(s): COVID-19 epidemiological studies
2022 - Springer Science+Business Media | European Journal of Epidemiology
Derek Zieker, Elvira Fehrenbach, Janko Dietzsch, Judith Fliegner, Marc Waidmann, Kay Nieselt, Peter J. Gebicke‐Haerter, Rainer Spanagel, Perikles Simon, Andreas M. Nieß, Hinnak Northoff,
It is generally accepted that exhausting endurance exercise exhibits strong effects on the immune system. Such effects have been attributed to changes in the cellular composition of peripheral blood as well as to changes in the expression of plausible candidate genes. The list of candidate genes is far from being complete, since this issue has not yet been investigated in a systematic way. In this study, we used a custom-made cDNA microarray focused on inflammation as a screening approach to study ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2005 - American Physical Society | Physiological Genomics
Joël LeMaoult, Sylvie Delassus, R Dyall, Janko Nikolić‐Žugić, Philippe Kourilsky, Marc E. Weksler,
The effect of age on the diversity of the murine Ig heavy chain repertoire has been studied in unimmunized C57BL/6 mice. We examined the heterogeneity of complementarity-determining region 3 (CDR3) sizes of Ig mRNA of the IgM and IgG isotypes using two VH families, VHJ558 and VHQ52, which together account for approximately 65% of the Ab repertoire. The broad and bell-shaped profiles representing the diversity of the VHJ558 family in the spleen of 2- to 6-mo-old C57BL/6 mice becomes significantly ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
1997 - American Association of Immunologists | The Journal of Immunology
Stephan Dürr, Christina Janko, Stefan Lyer, Philipp Tripal, Marc Schwarz, Jan Zaloga, Rainer Tietze, Christoph Alexiou,
Abstract Cancer is one of the biggest challenges facing the medical research in our time. The goals are to improve not only the therapeutic outcome, even in the cases of advanced and metastatic cancer, but also the methods of treatment, which often have considerable adverse effects. In addition, the current developments, such as demographic change, population growth, and increasing healthcare costs, have to be taken into consideration. In all likelihood, nanotechnology and, in particular, the use ...
Tópico(s): Chemical Reactions and Isotopes
2013 - De Gruyter | Nanotechnology Reviews
Janko Samardžić, Karel Allegaert, Mélanie Wilbaux, Marc Pfister, John N. van den Anker,
Introduction: For safe and effective neonatal antibiotic therapy, knowledge of the pharmacokinetic parameters of antibacterial agents in neonates is a prerequisite. Fast maturational changes during the neonatal period influence pharmacokinetic and pharmacodynamic parameters and their variability. Consequently, the need for applying quantitative clinical pharmacology and determining optimal drug dosing regimens in neonates has become increasingly recognized.Areas covered: Modern quantitative approaches, ...
Tópico(s): Hemodynamic Monitoring and Therapy
2016 - Taylor & Francis | Expert Opinion on Drug Metabolism & Toxicology
Joël LeMaoult, Ilhem Messaoudi, John S. Manavalan, Heather Potvin, Dragana Nikolich-Žugich, Ruben Dyall, Paul Szabo, Marc E. Weksler, Janko Nikolich‐Žugich,
Abstract Relative diversity and representation of peripheral T cells bearing different TCR Vβ families are remarkably tightly regulated between birth and advanced adulthood. By contrast, individual elderly humans and C3H.SW and B10.BR aged mice display drastic disruption in such regulation. It was suggested that the alterations in the murine aged T cell compartment were due to age-related clonal T cell expansions (TCE). Here, we studied the kinetics of homeostatic dysregulation of T cell populations ...
Tópico(s): T-cell and B-cell Immunology
2000 - American Association of Immunologists | The Journal of Immunology
Guillaume Suárez, Young‐Hyun Jin, Janko Auerswald, Stefan Berchtold, Helmut Knapp, Jean-Marc Diserens, Y. Leterrier, Jan‐Anders E. Månson, Guy Voirin,
A multiplexed immunoassay-based antibiotic sensing device integrated in a lab-on-a-chip format is described. The approach is multidisciplinary and involves the convergent development of a multi-antibiotic competitive immunoassay based on sensitive wavelength interrogated optical sensor (WIOS) technology and a polymer-based self-contained microfluidic cartridge. Immunoassay solutions are pressure-driven through external and concerted actuation of a single syringe pump and multiposition valve. Moreover, ...
Tópico(s): Microfluidic and Bio-sensing Technologies
2009 - Royal Society of Chemistry | Lab on a Chip
Mark Janko, Seth R. Irish, Brian J. Reich, Marc Peterson, Stephanie M. Doctor, Melchior Kashamuka Mwandagalirwa, Joris Losimba Likwela, Antoinette Tshefu, Steven R. Meshnick, Michael Emch,
BackgroundThe relationship between agriculture, Anopheles mosquitoes, and malaria in Africa is not fully understood, but it is important for malaria control as countries consider expanding agricultural projects to address population growth and food demand. Therefore, we aimed to assess the effect of agriculture on Anopheles biting behaviour and malaria risk in children in rural areas of the Democratic Republic of the Congo (DR Congo).MethodsWe did a population-based, cross-sectional, spatial study ...
Tópico(s): Zoonotic diseases and public health
2018 - Elsevier BV | The Lancet Planetary Health
Bosa Mirjanić-Azarić, Jelena Vekić, Aleksandra Zeljković, Zorana Jelić‐Ivanović, Mirjana Djerić, Tatjana Milivojac, Urša Pečar Fonović, Janja Marc, Janko Kos, Darko Černe,
Aim: We hypothesized that, in stable angina patients, atorvastatin therapy lowers the cathepsin S (CTSS) concentrations, as assessed non-invasively according to a plasma analysis. In addition, the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in the plasma were analysed to establish the association between CTSS and lipoprotein metabolism and determine whether this association is atorvastatin-sensitive. Methods: A total of 43 patients with stable angina received ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2014 - Japan Atherosclerosis Society | Journal of Atherosclerosis and Thrombosis
Markus Zabel, Christian Sticherling, Rik Willems, Andrzej Lubiński, Axel Bauer, Leonard Bergau, Frieder Braunschweig, Josép Brugada, Sandro Brusich, David Conen, Iwona Cygankiewicz, Panagiota Flevari, Miloš Táborský, Jim Hansen, Gerd Hasenfuß, Róbert Hatala, Heikki V. Huikuri, Svetoslav Iovev, Stefan Kääb, Gabriela Kaliská, Jarosław D. Kasprzak, Lars Lüthje, Marek Malík, Tomáš Novotný, Nikola Pavlović, Georg Schmidt, Tchavdar Shalganov, Rajeeva Sritharan, Simon Schlögl, Janko Szavits Nossan, Vassil Traykov, Anton E. Tuinenburg, Vasil Velchev, Marc A. Vos, Stefan N. Willich, Tim Friede, Jesper Hastrup Svendsen, Béla Merkely,
Abstract Aims The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU‐CERT‐ICD) aims to assess its current clinical value. Methods and results The EU‐CERT‐ICD is a prospective investigator‐initiated non‐randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European ...
Tópico(s): Cardiac Arrhythmias and Treatments
2018 - Wiley | ESC Heart Failure
H. Daniel Lacorazza, José A. Guevara Patiño, Marc E. Weksler, Dorel L. Radu, Janko Nikolić‐Žugić,
After puberty, the thymus undergoes a dramatic loss in volume, in weight and in the number of thymocytes, a phenomenon termed age-associated thymic involution. Recently, it was reported that age-associated thymic involution did not occur in mice expressing a rearranged transgenic (Tg) TCRalphabeta receptor. This finding implied that an age-associated defect in TCR rearrangement was the major, if not the only, cause for thymic involution. Here, we examined thymic involution in three other widely used ...
Tópico(s): Immune Cell Function and Interaction
1999 - American Association of Immunologists | The Journal of Immunology
Mélanie Wilbaux, Aline Fuchs, Janko Samardžić, Frédérique Rodieux, Chantal Csajka, Karel Allegaert, Johannes N. van den Anker, Marc Pfister,
Abstract Sepsis remains a major cause of mortality and morbidity in neonates, and, as a consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient population. Growth and dynamic maturation processes during the first weeks of life result in large inter‐ and intrasubject variability in the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics. In this review we (1) summarize the available population PK data and models for primarily renally eliminated antibiotics, ( ...
Tópico(s): Hemodynamic Monitoring and Therapy
2016 - Wiley | The Journal of Clinical Pharmacology
C Blum, Daniel Schneeberger, Matthias Läng, Janko Rakic, Marc Michot, Christian Müller,
Introduction . Diagnosis of adrenal crisis and panhypopituitarism in patients with septic shock is difficult but crucial for outcome. Case . A 66-year-old woman with metastasized breast cancer presented to the ED with respiratory insufficiency and septic shock after a 2-day history of the flu. After transfer to the ICU, corticosteroids were started in addition to antibiotics, as the patient was vasopressor-nonresponsive. Diabetes insipidus was diagnosed due to polyuria and treated with 4 mg desmopressin. ...
Tópico(s): Sepsis Diagnosis and Treatment
2017 - Hindawi Publishing Corporation | Case Reports in Critical Care
Markus Zabel, Rik Willems, Andrzej Lubiński, Axel Bauer, Josép Brugada, David Conen, Panagiota Flevari, Gerd Hasenfuß, Martin Svetlošák, Heikki V. Huikuri, Marek Malík, Nikola Pavlović, Georg Schmidt, R. Sritharan, Simon Schlögl, Janko Szavits-Nossan, Vassil Traykov, Anton E. Tuinenburg, Stefan N. Willich, Markus Harden, Tim Friede, Jesper Hastrup Svendsen, Christian Sticherling, Béla Merkely, Béla Merkely, Péter Perge, Zoltán Salló, Gábor Széplaki, Nándor Szegedi, Klaudia Vivien Nagy, Markus Zabel, Lars Lüthje, Simon Schlögl, R. Sritharan, Helge Haarmann, Leonard Bergau, Joachim Seegers, Gerd Hasenfuß, Pascal Muñoz-Exposito, Tobias Tichelbäcker, Aleksandra Kirova, Gerd Hasenfuß, Tim Friede, Markus Zabel, Simon Schlögl, Tim Friede, Markus Harden, Marek Malík, Katerina Hnatkova, Marc A. Vos, Stefan N. Willich, Thomas Reinhold, Rik Willems, Bert Vandenberk, Magdalena Klinika, Janko Szavits-Nossan, Luka Rotkvić, Panayota Flevari, Ανδρέας Κατσιμάρδος, Dimitrios Katsaras, Róbert Hatala, Martin Svetlošák, Andrzej Lubiński, Tomasz Kuczejko, Jim Hansen, Christian Sticherling, David Conen, Nikola Pavlović, Šime Manola, Ozren Vinter, Ivica Benko, Anton E. Tuinenburg, David J. Sprenkeler, Agnieszka Smoczyńska, Marc A. Vos, Axel Bauer, Christine Meyer‐Zürn, Christian Eick, Jesper Hastrup Svendsen, Josép Brugada, Elena Arbelo, Gabriela Kaliská, Jozef Martinek, Georg Schmidt, Michael Dommasch, Alexander Steger, Stefan Kääb, Axel Bauer, Moritz F. Sinner, Konstantinos D. Rizas, Wolfgang Hamm, Vassil Traykov, Iwona Cygankiewicz, Paweł Ptaszyński, Krzysztof Kaczmarek, Izabela Poddębska, Svetoslav Iovev, Tomáš Novotný, Milan Kozák, Heikki V. Huikuri, Tuomas Kenttä, Ari Pelli, Jarosław D. Kasprzak, Dariusz Qavoq, Sandro Brusich, Ervin Avdović, Marina Klasan, Jan Gałuszka, Miloš Táborský, Vasil Velchev, Rüdiger Dißmann, Tchavdar Shalganov, Przemysław Guzik, Tomasz Krauze, Dieter Bimmel, Christiane Lieberz, Klinikum Ludwigsburg, Stefan Stefanow, Norman Rüb, Christian Wolpert, Joachim Seegers, Lars S Meier, Steffen Behrens, Zrinka Jurišić, Frieder Braunschweig, Florian Blaschke, Burkert Pieske, Zoran Bakotić, Ante Anić, Klinikum Weiden, Robert H. G. Schwinger, Pyotr G. Platonov, Gerian Grönefeld, Thomas Klingenheben,
The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter-Defibrillators (EU-CERT-ICD), a prospective investigator-initiated, controlled cohort study, was conducted in 44 centres and 15 European countries. It aimed to assess current clinical effectiveness of primary prevention ICD therapy.We recruited 2327 patients with ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and guideline indications for prophylactic ICD implantation. ...
Tópico(s): Cardiomyopathy and Myosin Studies
2020 - Oxford University Press | European Heart Journal
Hendrik Bonnemeier, Uwe Wiegand,
... 1996; 93: 1043–1065.CrossrefMedlineGoogle Scholar3 Hoffmann E, Janko S, Steinbeck G, et al. Onset scenarios of paroxysmal atrial fibrillation using new diagnostic pacemaker functions. Pacing Clin Electrophysiol. 2000; 23: 656.Abstract.Google ScholarcirculationahaCirculationCirculationCirculation0009-73221524-4539Lippincott Williams & WilkinsResponseBettoni Marco, and Zimmermann Marc, 11022003We were interested in the comments by Drs ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2003 - Lippincott Williams & Wilkins | Circulation
Ari Pelli, Juhani Junttila, Tuomas Kenttä, Simon Schlögl, Markus Zabel, Marek Malík, Tobias Reichlin, Rik Willems, Marc A. Vos, Markus Harden, Tim Friede, Christian Sticherling, Heikki V. Huikuri, Elena Arbelo, Axel Bauer, Frieder Braunschweig, Josép Brugada, David Conen, Iwona Cygankiewicz, Michael Dommasch, Christian Eick, Panagiota Flevari, Tim Friede, Jan Gałuszka, Jim Hansen, Róbert Hatala, Markus Harden, Katerina Hnatkova, Heikki V. Huikuri, Juhani Junttila, Stefan Kääb, Gabriela Kaliská, Jarosław D. Kasprzak, Ανδρέας Κατσιμάρδος, Milan Kozák, Tomasz Kuczejko, Andrzej Lubiński, Jozef Martinek, Béla Merkely, Tomáš Novotný, Marek Malík, Péter Perge, Burkert Pieske, Pyotr G. Platonov, Pawel Ptaczyński, Dariusz Qavoq, Luka Rotkvić, Zoltán Salló, Simon Schlögl, Georg Schmidt, Moritz F. Sinner, Rajeeva Sritharan, Stefan Stefanow, Christian Sticherling, Jesper Hastrup Svendsen, Martin Svetlošák, Janko Szavits-Nossan, Miloš Táborský, Anton E. Tuinenburg, Bert Vandenberk, Marc A. Vos, Rik Willems, Stefan N. Willich, Christian Wolpert, Markus Zabel, Ante Anić, Zoran Bakotić, Steffen Behrens, Dieter Bimmel, Sandro Brusich, Rüdiger Dißmann, Gerian Grönefeld, Przemyzlav Guzik, Svetoslav Iovev, Zrinka Jurišić, Thomas Klingenheben, Nikola Pavlović, Joachim Seegers, Robert H. G. Schwinger, Tchavdar Shalganov, Vassil Traykov, Vasil Velchev,
Abstract Aim The association of standard 12-lead electrocardiogram (ECG) markers with benefits of the primary prophylactic implantable cardioverter-defibrillator (ICD) has not been determined in the contemporary era. We analysed traditional and novel ECG variables in a large prospective, controlled primary prophylactic ICD population to assess the predictive value of ECG in terms of ICD benefit. Methods and results Electrocardiograms from 1477 ICD patients and 700 control patients (EU-CERT-ICD; non- ...
Tópico(s): Cardiac Arrhythmias and Treatments
2021 - Oxford University Press | EP Europace
Lucas Boeck, Joan B. Soriano, Marjolein Brusse‐Keizer, Francesco Blasi, Κonstantinos Κostikas, Wim Boersma, Branislava Milenković, Renaud Louis, Alícia Lacoma, Remco S. Djamin, Joachim G.J.V. Aerts, Antoní Torres, Gernot Rohde, Tobias Welte, Pablo Martínez‐Camblor, Janko Rakic, Andreas Scherr, Michael Koller, Job van der Palen, José M. Marı́n, Inmaculada Alfageme, Pere Almagro, Ciro Casanova, Cristóbal Esteban, Juan José Soler‐Cataluña, Juan P. de‐Torres, Marc Miravitlles, Bartolomé R. Celli, Michael Tamm, Daiana Stolz,
Several composite markers have been proposed for risk assessment in chronic obstructive pulmonary disease (COPD). However, choice of parameters and score complexity restrict clinical applicability. Our aim was to provide and validate a simplified COPD risk index independent of lung function.The PROMISE study (n=530) was used to develop a novel prognostic index. Index performance was assessed regarding 2-year COPD-related mortality and all-cause mortality. External validity was tested in stable and ...
Tópico(s): Emergency and Acute Care Studies
2016 - European Respiratory Society | European Respiratory Journal
Gregory Y.H. Lip, Agnieszka Kotalczyk, Christine Teutsch, Hans‐Christoph Diener, Sérgio Dubner, Jonathan L. Halperin, Changsheng Ma, Kenneth J. Rothman, Sabrina Marler, Venkatesh Kumar Gurusamy, Menno V. Huisman, Dzifa Wosornu Abban, Emad F. Aziz, Marica Bracic Kalan, Nasser Abdul, Luciano Marcelo Backes, Drew Bradman, Atilio Marcelo Abud, Erik Badings, Donald Brautigam, Fran Adams, Ermentina Bagni, Nicolas Breton, Srinivas Addala, Seth Baker, Paul J.A.M. Brouwers, Pedro Adragão, Richard Bala, Kevin F. Browne, Walter Ageno, Antonio Baldi, Jordi Bruguera Cortada, Rajesh Aggarwal, Shigenobu Bando, Adriana Antonella Bruni, Sergio Agosti, Subhash Banerjee, Claude Brunschwig, Piergiuseppe Agostoni, Alan J. Bank, Hervé Buathier, Francisco Aguilar, Gonzalo Barón‐Esquivias, Aurélie Buhl, Julio Aguilar Linares, Craig Barr, John Bullinga, Luis Aguinaga, Maria Bartlett, Jose Walter Cabrera, Jameel Ahmed, Vanja Bašić Kes, Alberto Caccavo, Allessandro Aiello, Giovanni Baula, Shanglang Cai, Paul Ainsworth, Steffen Behrens, Sarah Caine, Jorge Roberto Aiub, Alan Bell, Leonardo Calò, Raed Al-Dallow, Raffaella Benedetti, Valéria Calvi, Lisa Alderson, Juan Benezet Mazuecos, Mauricio Camarillo Sánchez, Jorge Antonio Aldrete Velasco, Bouziane Benhalima, Rui Candeias, Dimitrios Alexopoulos, Jutta Bergler‐Klein, Vincenzo Capuano, Fernando Alfonso Manterola, Jean-Baptiste Berneau, Alessandro Capucci, Pareed Aliyar, Richard A. Bernstein, Ronald Caputo, David Alonso, Percy Berrospi, Tatiana Cárdenas Rizo, Fernando Augusto Alves da Costa, Sergio Berti, Francisco Cardona, José Amado, Andrea Berz, Francisco Darrieux, W. Amara, Elizabeth A. Best, Yan Carlos Duarte Vera, Mathieu Amelot, Paulo Bettencourt, Antonio Carolei, Nima Amjadi, Robert Betzu, Susana Carreño, Fabrizio Ammirati, Ravi Bhagwat, Paula Carvalho, Marianna Andrade, Luna Bhatta, Susanna Cary, Nabil Andrawis, Francesco Biscione, Gavino Casu, Giorgio Annoni, Giovanni Bisignani, Claudio Cavallini, Gerardo Ansalone, Toby Black, Guillaume Cayla, M. Kevin Ariani, Michael J. Bloch, Aldo Celentano, Juan Carlos Arias, Stephen R. Bloom, Tae‐Joon Cha, Sébastien Armero, Edwin Blumberg, Kwang Soo, Chander Arora, Mario Bo, Jei Keon Chae, Muhammad Shakil Aslam, Ellen Bøhmer, Kathrine Chalamidas, M. Asselman, Andreas Bollmann, Krishnan Challappa, Philippe Audouin, Maria Grazia Bongiorni, Sunil Prakash Chand, Charles Augenbraun, Giuseppe Boriani, Harinath Chandrashekar, Şenay Aydın, D. J. Boswijk, Ludovic Chartier, Şenay Aydın, Jochen Bott, Kausik Chatterjee, Ivaneta Ayryanova, E. Bottacchi, Carlos Antero Chavez Ayala, Aamir Cheema, Gershan Davis, Rudolph Evonich, Amjad Cheema, Jean‐Marc Davy, Oksana Evseeva, Lin Chen, Mark Dayer, Andrey Ezhov, Shih‐Ann Chen, Marzia De Biasio, Raed Fahmy, Jyh Hong Chen, Silvana De Bonis, Quan Fang, Fu‐Tien Chiang, Raffaele De Caterina, Ramin Farsad, Francesco Chiarella, Teresiano De Franceschi, Laurent Fauchier, Lin Chih-Chan, Joris R. de Groot, Stefano Favale, Yong Keun Cho, José de Anchieta C. Horta‐Júnior, Maxime Fayard, Jong‐Il Choi, Axel De La Briolle, José Luis Fedele, Dong Ju Choi, Gilberto de la Peña Topete, Francesco Fedele, Guy Chouinard, Ângelo Amato Vicenzo de Paola, Olga Fedorishina, Danny Hoi-Fan Chow, Weimar Kunz Sebba Barroso, Steven R. Fera, Dimitrios Chrysos, A. de Veer, Luís Gustavo Gomes Ferreira, Г. А. Чумакова, Luc De Wolf, Jorge Ferreira, Eduardo Julián José Roberto Chuquiu Valenzuela, Eric Decoulx, Claudio Ferri, Nicoleta Cindea Nica, Sasalu Deepak, Anna Ferrier, David J. Cislowski, Pascal Defaye, Hugo Ferro, Anthony Clay, Freddy Del‐Carpio Munoz, Alexandra Vanessa Finsen, Piers Clifford, Diana Delić-Brkljačić, Brian First, Andrew S. Cohen, N. Joseph Deumite, Stuart G. Fischer, Michael N. Cohen, Silvia Di Legge, Ana Catarina Fonseca, Serge X. Cohen, Igor Diemberger, Luísa Fonseca Almeida, Furio Colivicchi, Denise Dietz, Steven L. Forman, Rónán Collins, Pedro Dionísio, Brad Frandsen, Paolo Colonna, Qiang Dong, William J. French, S. Compton, Fabio Rossi dos Santos, Keith Friedman, Derek Connolly, Elena Dotcheva, Athena Friese, Alberto Conti, Rami Doukky, Ana Gabriela Fruntelata, Gabriel Contreras Buenostro, Anthony D’Souza, Shigeru Fujii, Gregg Coodley, Simon W Dubrey, Stefano Fumagalli, Martin Cooper, Xavier Ducrocq, Marta Fundamenski, Julián Coronel, Dmitry Dupljakov, Yutaka Furukawa, Giovanni Corso, Mauricio Duque, M. Gabelmann, Juan Cosı́n-Sales, Dipankar Dutta, Nashwa Gabra, Yves Cottin, Nathalie Duvilla, Niels Gadsbøll, John Covalesky, A Duygun, Michel Galinier, Aurel Cracan, Rainer Dziewas, Anders Gammelgaard, Filippo Crea, Charles B. Eaton, Priya Ganeshkumar, Peter Crean, William Eaves, Christopher Gans, James Crenshaw, L. A. Ebels-Tuinbeek, Antonio Garcia Quintana, Tina Cullen, Clifford Ehrlich, Olivier Gartenlaub, Harald Darius, Sabine Eichinger-Hasenauer, Achille Gaspardone, Patrick Dary, Steven Eisenberg, Conrad Genz, Olivier Dascotte, Adnan El Jabali, F. Georger, Ira Dauber, Mahfouz El Shahawy, Jean‐Louis Georges, Vicente Davalos, Mauro Esteves Hernandes, Steven Georgeson, Ruth Davies, Ana Etxeberria Izal, Evaldas Giedrimas, Mariusz Gierba, Tetsuya Haruna, Nabil Jarmukli, I. Ortega, Emil Hayek, Robert Jeanfreau,
Abstract Background and purpose Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban ...
Springer Science+Business Media
Markus Zabel, Simon Schlögl, Andrzej Lubiński, Jesper Hastrup Svendsen, Axel Bauer, Elena Arbelo, Sandro Brusich, David Conen, Iwona Cygankiewicz, Michael Dommasch, Panagiota Flevari, Jan Gałuszka, Jim Hansen, Gerd Hasenfuß, Róbert Hatala, Heikki V. Huikuri, Tuomas Kenttä, Tomasz Kucejko, Helge Haarmann, Markus Harden, Svetoslav Iovev, Stefan Kääb, Gabriela Kaliská, Ανδρέας Κατσιμάρδος, Jarosław D. Kasprzak, Dariusz Qavoq, Lars Lüthje, Marek Malík, Tomáš Novotný, Nikola Pavlović, Péter Perge, Christian Röver, Georg Schmidt, Tchavdar Shalganov, Rajeeva Sritharan, Martin Svetlošák, Zoltán Salló, Janko Szavits-Nossan, Vassil Traykov, Bert Vandenberk, Vasil Velchev, Marc A. Vos, Stefan N. Willich, Tim Friede, Rik Willems, Béla Merkely, Christian Sticherling,
BACKGROUND. The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. It is urgently needed to better identify patients who benefit from prophylactic ICD therapy. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) completed in 2019 will assess this issue. SUMMARY. The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, ...
Tópico(s): Cardiomyopathy and Myosin Studies
2019 - Elsevier BV | Journal of Electrocardiology
Marko Kazimirović, Branko Stajić, Nenad Petrović, Janko Ljubičić, Olivera Košanin, Marc Hanewinkel, Dominik Sperlich,
Abstract Key message We applied the generalized algebraic difference approach (GADA) to develop dynamic models of height growth for pedunculate oak ( Quercus robur L.) in Serbia. According to the dominant heights, the studied region comprises some of Europe’s most productive sites for pedunculate oak. Therein, we have generated a map showing the current site index class of stands. Such a map could be used to enhance forest management and evaluate climate change impacts. Context Although sustainable ...
Tópico(s): Forest Management and Policy
2024 - Springer Science+Business Media | Annals of Forest Science
Tópico(s): Themes in Literature Analysis
1955 - Wiley | The Russian Review
Marc Schwarz, Arnd Dörfler, Tobias Engelhorn, Tobias Struffert, Rainer Tietze, Christina Janko, Philipp Tripal, Iwona Cicha, Stephan Dürr, Christoph Alexiou, Stefan Lyer,
Abstract The use of nanoparticles in tumor imaging, molecular imaging, and drug delivery has significantly expanded in the last few years. The relatively new field of “theranostics” combines their capacity for drug delivery with their potential as contrast agents. Depending on the imaging modality used, several types of nanoparticles are available, such as gold for optical imaging or superparamagnetic iron oxide for magnetic resonance imaging. This review will give a short overview of the different ...
Tópico(s): Nanoplatforms for cancer theranostics
2013 - De Gruyter | Nanotechnology Reviews
... Georg Schmidt, Tchavdar Shalganov, Rajeeva Sritharan, Simon Schlögl, Janko Szavits Nossan, Vassil Traykov, Anton E. Tuinenburg, Vasil Velchev, Marc A. Vos, Stefan N. Willich, Tim Friede, Jesper ...
Tópico(s): Heart Failure Treatment and Management
2019 - Wiley | ESC Heart Failure
Mojca Božič Mijovski, Vinko Boc, Urša Pečar Fonović, Janja Marc, Aleš Blinc, Janko Kos, Darko Černe,
We tested the hypothesis that increased levels of cathepsin S and decreased levels of cystatin C in plasma at the time of percutaneous transluminal angioplasty (PTA) are associated with the occurrence of 6-months' restenosis of the femoropopliteal artery (FPA).20 patients with restenosis and 24 matched patients with patent FPA after a 6-months follow-up were in - cluded in this study. They all exhibited disabling claudication or critical limb ischemia and had undergone technically successful PTA. They ...
Tópico(s): Acute Ischemic Stroke Management
2017 - De Gruyter | Journal of Medical Biochemistry
Nasreen Hassoun‐Kheir, C. Henri van Werkhoven, Jake Dunning, Thomas Jaenisch, Janko van Beek, Julia Bielicki, Christopher Butler, Bruno François, Stéphan Harbarth, Ana Catalina Hernandez Padilla, Peter Horby, Marion Koopmans, James Lee, Jesús Rodríguez‐Baño, Evelina Tacconelli, Yrene Themistocleous, Alike W. van der Velden, Marc J. M. Bonten, Herman Goossens, Marlieke E.A. de Kraker,
The increasing threat of emerging infectious diseases and antimicrobial resistance requires more efficient, high-quality research. Perpetual Observational Studies (POS) nested within a clinical research network can improve planning, quality and efficiency of interventional and observational studies, although real-life benefits and challenges need to be assessed. Ecraid (European Clinical Research Alliance on Infectious Diseases) has initiated POS and will monitor the impact for five specific infectious ...
Tópico(s): Meta-analysis and systematic reviews
2022 - Elsevier BV | Clinical Microbiology and Infection
Kristine M. Erlandson, Linda N. Geng, Caitlin Selvaggi, Tanayott Thaweethai, Peter Chen, Nathan Erdmann, Jason D. Goldman, Timothy J. Henrich, Mady Hornig, Elizabeth W. Karlson, Stuart D. Katz, Chun Kim, Sushma K. Cribbs, Adeyinka O. Laiyemo, Rebecca Letts, Janet Lin, Jai Marathe, Sairam Parthasarathy, Thomas F. Patterson, Brittany D. Taylor, Elizabeth R. Duffy, Monika Haack, Boris Jülg, Gabrielle Maranga, Carla Hernandez, Nora G. Singer, Jenny E. Han, Priscilla Pemu, Hassan Brim, Hassan Ashktorab, Alexander W. Charney, Juan P. Wisnivesky, Jenny J. Lin, Helen Y. Chu, Minjoung Go, Upinder Singh, Emily B. Levitan, Paul Goepfert, Janko Ž. Nikolich, Harvey Hsu, Michael J. Peluso, J. Daniel Kelly, Megumi J. Okumura, Valerie J. Flaherman, John G. Quigley, Jerry A. Krishnan, Mary Beth Scholand, Rachel Hess, Torri D. Metz, Maged M. Costantine, Dwight J. Rouse, Barbara S. Taylor, Mark P. Goldberg, Gailen D. Marshall, Jeremy P. Wood, David E. Warren, Leora I. Horwitz, Andrea S. Foulkes, Grace A. McComsey, Jeffrey P. Burns, Serena Spudich, L. Charles Bailey, Mine S. Cicek, Melissa Cortez, Felicia Davis Blakley, Andrea S. Foulkes, David C. Goff, Stuart D. Katz, Jessica Lasky‐Su, Torri D. Metz, Lisa T. Newman, Igho Ofotokun, Sudha Seshadri, Melissa S. Stockwell, James R. Stone, Brittany D. Taylor, PJ Utz, Neely Williams, Hassan Ashktorab, Jeannette M. Beasley, Karyn Bishof, Yu Chen, Lori B. Chibnik, Dani Dumitriu, Jennifer Frontera, Paul Goepfert, Sylvie Goldman, Stephen M. Hewitt, Matthew J. Huentelman, Barbara I. Karp, Jerry A. Krishnan, Sarah Laury, Bruce D. Levy, Janko Nikolich‐Žugich, Margaret J. Ochocinska, Laura Pace, Alice Perlowski, William Reeves, Juan C. Salazar, Lumy Sawaki-Adams, Sujata Thawani, Hannah Valantine, Drenna Waldrop, Dana L. Wolff‐Hughes, Marta Cerda, Victor H. Clash, Felicia Davis Blakley, Brittany Taylor, Mike Zissis, Teresa Akintonwa, Frank Blancero, Heather-Elizabeth Brown, Megan Carmilani, Debra Copeland, Yvonka Hall, Kevin Kondo, Lydia Lerma, Jacqui Lindsay, Heather Marti, Christine Maughan, Tony Minor, Hyatt Vincent, Andra L. Blomkalns, David Warburton, Ingrid V. Bassett, Rebecca G. Clifton, Hannah Davis, Nathan Erdmann, Valerie J. Flaherman, Margot Gage Witvliet, Mark P. Goldberg, Zoe Guan, Jonathan D. Klein, Gregory Laynor, Thomas F. Martínez, Rebecca McGrath, Sairam Parthasarathy, Priscilla Pemu, Erika B. Rosenzweig, Jacqueline Rutter, Hugh Auchincloss, Diana W. Bianchi, Jennifer Moss Breen, Paul M. Brennan, Jeffrey P. Burns, Nakela L. Cook, Felicia Davis Blakley, Betty Diamond, Mitchell S.V. Elkind, Lee Fleisher, Andrea S. Foulkes, Gary H. Gibbons, Laurie Gutmann, Michael F. Iademarco, Stuart D. Katz, Walter J. Koroshetz, Eldrin F. Lewis, Peter Marks, Hilary D. Marston, Mitchell G. Miglis, Lisa A. Newman, Tracy L. Nolen, Carlos A. Pardo, Amy Patterson, Samuel F. Posner, Wendy S. Post, Serena Spudich, Clinton B. Wright, Heather E. Yates, Kanecia O. Zimmerman, Gabriel Anaya, Audie A. Atienza, L. Charles Bailey, R. Graham Barr, Lisa G. Berdan, Andra L. Blomkalns, Melissa L. Bondy, Hassan Brim, Jeffrey P. Burns, Alexander W. Charney, Benjamin K. Chen, Mine S. Cicek, John F. Crary, Dawood Darbar, Kathi Diviak, Ray F. Ebert, Jamie Elifritz, Robert L. Ferrer, Joshua P. Fessel, Aloke V. Finn, Thomas J. Flotte, Paul Fontelo, Andrea S. Foulkes, Emily J. Gallagher, Maria Laura Gennaro, Mary Groesch, Rachel S. Gross, Melissa Haendel, James R. Heath, Rachel Hess, Stephen M. Hewitt, Sally Hodder, Carol R. Horowitz, Leora I. Horwitz, Vanessa L. Jacoby, Sarah E. Jolley, Suzanne E. Judd, Bill G. Kapogiannis, Elizabeth W. Karlson, Barbara I. Karp, Stuart D. Katz, Rainu Kaushal, Lawrence C. Kleinman, Jerry A. Krishnan, Sweta Ladwa, Craig Lefebvre, Lei Lei, Emily B. Levitan, Bruce D. Levy, Daniel Liu, Jeffrey N. Martin, Grace A. McComsey, Robin J. Mermelstein, Torri D. Metz, Lucio Miele, Sindhu Mohandas, Janet Mullington, Shawn N. Murphy, Jane W. Newburger, Lisa A. Newman, Margaret J. Ochocinska, Igho Ofotokun, Princess U. Ogbogu, Michelle Olive, Sairam Parthasarathy, Amy Patterson, Thomas F. Patterson, Gail D. Pearson, Priscilla Pemu, J. Zachary Porterfield, Antonello Punturieri, R. Ross Reichard, Jane E.B. Reusch, Kyung E. Rhee, Kathleen E. Rodgers, Juan C. Salazar, Amy L. Salisbury, Lumy Sawaki-Adams, Lisa Schwartz-Longacre, Sudha Seshadri, Howard D. Sesso, Eyal Shemesh, Allan C. Shipp, Upinder Singh, Jessica Snowden, Serena Spudich, Melissa S. Stockwell, James R. Stone, Jun Sun, Mehul S. Suthar, David M. Systrom, Brittany Taylor, Stephen N. Thibodeau, Andrea B. Troxel, PJ Utz, Tiffany Walker, David Warburton, Gail Weinmann, Neely Williams, Dana L. Wolff‐Hughes, John C. Wood, Khamal Anglin, Emilia Bagiella, Ryan C. Branski, Rodica Pop‐Busui, Marissa Diggs, Vivian S. Gainer, Sunanda Gaur, Linda N. Geng, Sarah E. Jolley, Sarah Laury, Jai Marathe, Lisa McCorkell, Jarrod Mosier, Binita Shah, Dimpy P. Shah, Tiffany Walker, Peter Whitesell, Natasha Altman, Tellen D. Bennett, Soham Dasgupta, Marissa Edminston, Tyler Gustafson, François Haddad, Jennifer Hossain, Priscilla Y. Hsue,
There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2 infection (PASC).
American College of Physicians
Giulio Francesco Romiti, Bernadette Corica, Marco Proietti, Davide Antonio Mei, Juliane Frydenlund, Arnaud Bisson, Giuseppe Boriani, Brian Olshansky, Yi‐Hsin Chan, Menno V. Huisman, Tze-Fan Chao, Gregory Y.H. Lip, Dzifa Wosornu Abban, Nasser Abdul, Atilio Marcelo Abud, Fran Adams, Srinivas Addala, Pedro Adragão, Walter Ageno, Rajesh Aggarwal, Sergio Agosti, Piergiuseppe Agostoni, Francisco Aguilar, Julio Aguilar Linares, Luis Aguinaga, Jameel Ahmed, Allessandro Aiello, Paul Ainsworth, Jorge Roberto Aiub, Raed Al-Dallow, Lisa Alderson, Jorge Antonio Aldrete Velasco, Dimitrios Alexopoulos, Fernando Alfonso Manterola, Pareed Aliyar, David Alonso, Fernando Augusto Alves da Costa, José Amado, W. Amara, Mathieu Amelot, Nima Amjadi, Fabrizio Ammirati, Marianna Andrade, Nabil Andrawis, Giorgio Annoni, Gerardo Ansalone, M. Kevin Ariani, Juan Carlos Arias, Sébastien Armero, Chander Arora, Muhammad Shakil Aslam, M. Asselman, Philippe Audouin, Charles Augenbraun, Şenay Aydın, Ivaneta Ayryanova, Emad F. Aziz, Luciano Marcelo Backes, Erik Badings, Ermentina Bagni, Seth Baker, Richard Bala, Antonio Baldi, Shigenobu Bando, Subhash Banerjee, Alan J. Bank, Gonzalo Barón‐Esquivias, Craig Barr, Maria Bartlett, Vanja Bašić Kes, Giovanni Baula, Steffen Behrens, Alan Bell, Raffaella Benedetti, Juan Benezet Mazuecos, Bouziane Benhalima, Jutta Bergler‐Klein, Jean-Baptiste Berneau, Richard A. Bernstein, Percy Berrospi, Sergio Berti, Andrea Berz, Elizabeth A. Best, Paulo Bettencourt, Robert Betzu, Ravi Bhagwat, Luna Bhatta, Francesco Biscione, Giovanni Bisignani, Toby Black, Michael J. Bloch, Stephen R. Bloom, Edwin Blumberg, Mario Bo, Ellen Bøhmer, Andreas Bollmann, Maria Grazia Bongiorni, Giuseppe Boriani, D.J. Boswijk, Jochen Bott, E. Bottacchi, Marica Bracic Kalan, Drew Bradman, D. H. Brautigam, Nicolas Breton, Paul J.A.M. Brouwers, Kevin F. Browne, Jordi Bruguera Cortada, Adriana Antonella Bruni, Claude Brunschwig, Hervé Buathier, Aurélie Buhl, John Bullinga, Jose Walter Cabrera, Alberto Caccavo, Shanglang Cai, Sarah Caine, Leonardo Calò, Valéria Calvi, Mauricio Camarillo Sánchez, Rui Candeias, Vincenzo Capuano, Alessandro Capucci, Ronald Caputo, Tatiana Cárdenas Rizo, Francisco Cardona, Francisco Darrieux, Yan Carlos Duarte Vera, Antonio Carolei, Susana Carreño, Paula Carvalho, Susanna Cary, Gavino Casu, Claudio Cavallini, Guillaume Cayla, Aldo Celentano, Tae‐Joon Cha, Kwang Soo, Jei Keon Chae, Kathrine Chalamidas, Krishnan Challappa, Sunil Prakash Chand, Harinath Chandrashekar, Ludovic Chartier, Kausik Chatterjee, Carlos Antero Chavez Ayala, Aamir Cheema, Amjad Cheema, Lin Chen, Shih‐Ann Chen, Jyh Hong Chen, Fu‐Tien Chiang, Francesco Chiarella, Lin Chih-Chan, Yong Keun Cho, Jong‐Il Choi, Dong Ju Choi, Guy Chouinard, Danny Hoi-Fan Chow, Dimitrios Chrysos, Г. А. Чумакова, Eduardo Julián José Roberto, Chuquiure Valenzuela, Nicoleta Cindea Nica, David J. Cislowski, Anthony Clay, Piers Clifford, Andrew Cohen, Michael N. Cohen, Serge Cohen, Furio Colivicchi, Rónán Collins, Paolo Colonna, Steve Compton, Derek Connolly, Alberto Conti, Gabriel Contreras Buenostro, Gregg Coodley, Martin Cooper, Julián Coronel, Giovanni Corso, Juan Cosı́n-Sales, Yves Cottin, John Covalesky, Aurel Cracan, Filippo Crea, Peter Crean, James Crenshaw, Tina Cullen, Harald Darius, Patrick Dary, Olivier Dascotte, Ira Dauber, Vicente Davalos, Ruth Davies, Gershan Davis, Jean‐Marc Davy, Mark Dayer, Marzia De Biasio, Silvana De Bonis, Raffaele De Caterina, Teresiano De Franceschi, Joris R. de Groot, José de Anchieta C. Horta‐Júnior, Axel De La Briolle, Gilberto de la Peña Topete, Ângelo Amato Vicenzo de Paola, Weimar Kunz Sebba Barroso, Anne de Veer, Luc De Wolf, Eric Decoulx, Sasalu Deepak, Pascal Defaye, Freddy Del‐Carpio Munoz, Diana Delić-Brkljačić, N. Joseph Deumite, Silvia Di Legge, Igor Diemberger, Denise Dietz, Pedro Dionísio, Qiang Dong, Fabio Rossi dos Santos, Elena Dotcheva, Rami Doukky, Anthony D’Souza, Simon W Dubrey, Xavier Ducrocq, Dmitry Dupljakov, Mauricio Duque, Dipankar Dutta, Nathalie Duvilla, A Duygun, Rainer Dziewas, Charles B. Eaton, William Eaves, Lisa Ehrlich, Sabine Eichinger-Hasenauer, Steven Eisenberg, Adnan El Jabali, Mahfouz El Shahawy, Mauro Esteves Hernandes, Ana Etxeberria Izal, Rudolph Evonich, Oksana Evseeva, Andrey Ezhov, Raed Fahmy, Quan Fang, Ramin Farsad, Laurent Fauchier, Stefano Favale, Maxime Fayard, José Luis Fedele, Francesco Fedele, Olga Fedorishina, Steven R. Fera, Luís Gustavo Gomes Ferreira, Jorge Ferreira, Claudio Ferri, Anna Ferrier, Hugo Ferro, Alexandra Vanessa Finsen, Brian First, Stuart G. Fischer, Ana Catarina Fonseca, Luísa Fonseca Almeida, Steven Forman, Brad Frandsen, William J. French, Keith Friedman, Athena Friese, Ana Gabriela Fruntelata, Shigeru Fujii, Stefano Fumagalli, Marta Fundamenski, Yutaka Furukawa, M. Gabelmann, Nashwa Gabra, Niels Gadsbøll, Michel Galinier, Anders Gammelgaard, Priya Ganeshkumar, Christopher Gans, Antonio Garcia Quintana, Olivier Gartenlaub, Achille Gaspardone, Conrad Genz, F. Georger, Jean‐Louis Georges, Steven Georgeson, Evaldas Giedrimas, Mariusz Gierba, I. Ortega, Eve Gillespie, Alberto Giniger, Michael Giudici, Alexandros Gkotsis,
Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study.From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non- ...
Elsevier BV
Tópico(s): EU Law and Policy Analysis
2010 - British Institute of International and Comparative Law | Common Market Law Review