... org/10.1103/PhysRevE.86.016105Joaquim Fort, Toni Pujol, Marc Vander Linden Modelling the Neolithic Transition in the ...
Tópico(s): Theoretical and Computational Physics
1961 - University of Chicago Press | Current Anthropology
Nicolas Daudet, Philippe Vago, Chantal Ripoll, Ghyslaine Humbert, Rémy Pujol, Marc Lenoir,
Hair cell regeneration is well documented in the inner ear sensory epithelia of lower vertebrates and birds and may occur in the vestibular organs of mammals. By contrast, hair cell loss in the mature mammalian cochlea is considered irreversible. However, recent reports have suggested that an attempt at hair cell regeneration could occur in vivo in aminoglycoside-lesioned cochleas from neonatal rats. After amikacin treatment, atypical cells with apical specialization reminiscent of early differentiating ...
Tópico(s): Cancer-related molecular mechanisms research
1998 - Wiley | The Journal of Comparative Neurology
Bertrand Napoléon, Maxime Palazzo, Anne‐Isabelle Lemaistre, Fabrice Caillol, Laurent Palazzo, Alain Aubert, Louis Buscail, Frédérique Maire, Blandine Mialhe Morellon, B. Pujol, Marc Giovannini,
Needle-based confocal laser endomicroscopy (nCLE) enables observation of the inner wall of pancreatic cystic lesions (PCLs) during an endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). This study prospectively evaluated the diagnostic performance of nCLE for large, single, noncommunicating PCLs using surgical histopathology or EUS-FNA cytohistopathology as a reference diagnosis.From April 2013 to March 2016, consecutive patients referred for EUS-FNA of indeterminate PCLs without evidence ...
Tópico(s): Gastrointestinal disorders and treatments
2018 - Thieme Medical Publishers (Germany) | Endoscopy
Frédéric Relaix, Josiane Demignon, Christine Laclef, Julien Pujol, Marc Santolini, Claire Niro, Mounia Lagha, Didier Rocancourt, Margaret Buckingham, Pascal Maire,
In mammals, several genetic pathways have been characterized that govern engagement of multipotent embryonic progenitors into the myogenic program through the control of the key myogenic regulatory gene Myod. Here we demonstrate the involvement of Six homeoproteins. We first targeted into a Pax3 allele a sequence encoding a negative form of Six4 that binds DNA but cannot interact with essential Eya co-factors. The resulting embryos present hypoplasic skeletal muscles and impaired Myod activation ...
Tópico(s): Ubiquitin and proteasome pathways
2013 - Public Library of Science | PLoS Genetics
David Pujol, Marc Bartrolí, Núria Fiol, Florencio de la Torre, Isabel Villaescusa, Jordi Poch,
Simultaneous sorption of Cr(VI), Cu(II) and Ni(II) onto exhausted coffee waste from binary mixtures was investigated. Equilibrium studies were carried out in binary mixtures in which Cr(VI) and the second metal ion concentration was varied between 0.5 and 12 mM and 0.5 and 8 mM, respectively. Equilibrium isotherms for each metal of the binary mixtures were determined by fixing the initial concentration of the second metal ion. Results showed that both components of the binary mixture exert a synergistic ...
Tópico(s): Extraction and Separation Processes
2013 - Elsevier BV | Chemical Engineering Journal
Sophie Pujol, Marc Berthillier, Jérôme Defrance, Joseph Lardiès, Rémy J. Petit, Hélène Houot, Jean-Pierre Levain, Cyril Masselot, Frédéric Mauny,
To investigate residential exposure to environmental noise among children in an urban area, a noise measurement campaign was performed at the residences of 44 schoolchildren. Outdoor and indoor noise levels were simultaneously recorded during one week inside and outside each child's bedroom and in the other room where each child spent most of his or her time, called "the main room". Associations between equivalent noise levels and familial or environmental characteristics were explored. The recorded ...
Tópico(s): Acoustic Wave Phenomena Research
2012 - Elsevier BV | Applied Acoustics
Jordi López‐Pujol, Marc Martinell, Sergi Massó, Cèsar Blanché, Llorenç Sáez,
Tópico(s): Plant Pathogens and Fungal Diseases
2012 - Springer Science+Business Media | Plant Systematics and Evolution
Joaquim Fort, Toni Pujol, Marc Vander Linden,
Abstract For the Neolithic transition in the Near East and Europe, this paper compares the isochrones predicted by computational models to those obtained by interpolating the archaeological data. This comparison reveals that there is a major inconsistency between the predictions of the models and the archaeological data: according to the models, the Neolithic front would have arrived to Greece in less than half the time interval implied by the data. Our main new results are as follows, (a) This inconsistency ...
Tópico(s): Isotope Analysis in Ecology
2012 - Cambridge University Press | American Antiquity
Claire Pujol, Marc Bailly, Daniel Kern, Laurence Maréchal‐Drouard, H. D. Becker, Anne-Marie Duchêne,
Aminoacyl-tRNAs are generally formed by direct attachment of an amino acid to tRNAs by aminoacyl-tRNA synthetases, but Gln-tRNA is an exception to this rule. Gln-tRNA(Gln) is formed by this direct pathway in the eukaryotic cytosol and in protists or fungi mitochondria but is formed by an indirect transamidation pathway in most of bacteria, archaea, and chloroplasts. We show here that the formation of Gln-tRNA(Gln) is also achieved by the indirect pathway in plant mitochondria. The mitochondrial- ...
Tópico(s): Photosynthetic Processes and Mechanisms
2008 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Sophie Gad, Virginie Caux‐Moncoutier, Sabine Pagès-Berhouet, Marion Gauthier‐Villars, Isabelle Coupier, Pascal Pujol, Marc Frénay, Brigitte Gilbert, Christine Maugard, Yves‐Jean Bignon, Annie Chevrier, Annick Rossi, Jean‐Pierre Fricker, Tan Dat Nguyen, Liliane Demange, Alain Aurias, Aaron Bensimon, Dominique Stoppa‐Lyonnet,
Genetic linkage data have shown that alterations of the BRCA1 gene are responsible for the majority of hereditary breast-ovarian cancers. However, BRCA1 germline mutations are found much less frequently than expected, especially as standard PCR-based mutation detection approaches focus on point and small gene alterations. In order to estimate the contribution of large gene rearrangements to the BRCA1 mutation spectrum, we have extensively analysed a series of 120 French breast-ovarian cancer cases. ...
Tópico(s): Ovarian cancer diagnosis and treatment
2002 - Springer Nature | Oncogene
R. Smalley, José Pujol, Marc Régnier, Jer‐Ming Chiu, Jean‐Luc Chatelain, Bryan L. Isacks, Mario Araújo, N. Puebla,
Data from a digitally recording seismic network in San Juan, Argentina, provide the first images of crustal scale basement faults beneath the Precordillera. This seismicity is near the boundary between the Precordillera (a thin‐skinned thrust belt) and the Sierras Pampeanas (a region of thick‐skinned basement deformation), two seismically active tectonic provinces of the Andean foreland. The seismicity data support models for this region in which crustal thickening, rather than magmatic addition or ...
Tópico(s): Geological and Geophysical Studies Worldwide
1993 - Wiley | Tectonics
Rémy Pujol, Marc Lenoir, Donald Robertson, Michel Eybalin, B. M. Johnstone,
Cochleas of adult guinea pigs and rats, and 6-day-old rat pups, were injected, through the round window, with 2 microliters of artificial classical Konishi perilymph containing 1 nmol kainic acid (KA). 5 min later, they were fixed, removed, and processed for electron microscopy. In all KA-treated cochleas, the injection resulted in a severe swelling of auditory dendrites below the inner hair cells (IHCs). Below the outer hair cells (OHCs), the swelling appeared only in the 6-day-old rats, not in adult ...
Tópico(s): Neuroscience and Neuropharmacology Research
1985 - Elsevier BV | Hearing Research
J.-P. Pujol, Marc Rolland, S Larsy, S Vinet,
1. Only the threads of Mytilacea contain collagen. 2. In Anomia, whose byssus is calcified, the acidic amino acids prevail over the basis ones. Glucosamine is very abundant. 3. Great differences are found between the species with reduced or little functional byssus (Heterodonta) and the species with well-developed and efficient ones (Pteriomorpha). In the first group, histidine appears but at very low level whereas aspartic acid as well as sulphur amino acids are much more abundant than in the second ...
Tópico(s): Cephalopods and Marine Biology
1970 - Pergamon Press | Comparative Biochemistry and Physiology
Marcin Polkowski, Alberto Larghi, Birgit Weynand, C. Boustière, Marc Giovannini, B. Pujol, Jean‐Marc Dumonceau,
This article is the second of a two-part publication that expresses the current view of the European Society of Gastrointestinal Endoscopy (ESGE) about endoscopic ultrasound (EUS)-guided sampling, including EUS-guided fine needle aspiration (EUS-FNA) and EUS-guided Trucut biopsy. The first part (the Clinical Guideline) focused on the results obtained with EUS-guided sampling, and the role of this technique in patient management, and made recommendations on circumstances that warrant its use. The current ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2011 - Thieme Medical Publishers (Germany) | Endoscopy
Sophie Pujol, Marc Berthillier, J. Defrance, Joseph Lardiès, Jean-Pierre Levain, Rémy J. Petit, H. Houot, Frédéric Mauny,
This article aims at evaluating indoor noise levels at home and investigating the factors that may influence their variability. An 8-day noise measurement campaign was conducted in the homes of 44 schoolchildren attending the public primary schools of Besançon (France). The presence of the inhabitants in the dwelling and the noisy events occurring indoors and outdoors was daily collected using a time-location-activity diary (TLAD); 902 time periods were analyzed. The indoor noise level increased significantly ...
Tópico(s): Vehicle Noise and Vibration Control
2014 - Wiley | Indoor Air
Pascal Schmitt, Jean-Marc Péquignot, Christine Garcia, J.F. Pujol, Jean-Marc Péquignot,
The present study was carried out to investigate the influence of long-term hypoxia on tyrosine hydroxylase (TH) protein quantity in some catecholaminergic rat brainstem areas such as the dorsomedial medulla (DMM), the ventrolateral medulla (VLM) and the locus coeruleus (LC). TH protein quantity was also measured in a dopaminergic structure, the substantia nigra (SN). Male Sprague-Dawley rats were exposed to normobaric hypoxia (10% O2/90% N2) for 3, 7, 14 or 22 days. Controls were kept in normoxia for ...
Tópico(s): Neuroscience of respiration and sleep
1993 - Elsevier BV | Brain Research
Pascal Schmitt, Jean-Marc Péquignot, F. Hanchin, Jean‐François Pujol, Jean-Marc Péquignot,
Dihydralazine, which is used in the treatment of hypertension, causes a long-lasting hypotensive action by a direct vasodilator effect on arteriolar smooth muscle. The present study was carried out to investigate the effect of a daily single injection of dihydralazine (20 mg/kg, s.c.) for 14 days on the tyrosine hydroxylase (TH) protein quantity in some catecholaminergic rat brainstem areas such as the dorsomedial medulla (DMM), the ventrolateral medulla (VLM) and the locus coeruleus (LC). This study ...
Tópico(s): Biochemical Analysis and Sensing Techniques
1993 - Elsevier BV | Brain Research
Geneviève Jolimoy Boilleau, Jean-Louis Pujol, Marc Ychou, P. Faurous, Charles Marty‐Ané, François-Bernard Michel, P. Godard,
Mediastinal lymph node metastasis is one of the most important prognostic variables of lung cancer. We designed a study to compare immunoscintigraphy (IS) using iodine-131 anti-carcinoembryonic antigen (CEA) and anti-carbohydrate 19-9 (CA 19-9) monoclonal antibody and computed tomography (CT-scan), in the setting of mediastinal staging. Seventeen patients were involved in a prospective, blind study, to compare IS with CT-scan imaging of the mediastinum. Sensitivity and specificity of both methods were ...
Tópico(s): Neuroendocrine Tumor Research Advances
1994 - Elsevier BV | Lung Cancer
Marc Pujol-González, Jesüs Cerquides, Pedro Meseguer, Juan A. Rodríguez-Aguilar, Milind Tambe,
This paper tackles the problem of allowing a team of UAVs with limited communication range to autonomously coordinate to service requests. We present two MRF-based solutions: one assumes independence between requests; and the other considers also the UAVs’ workloads. Empirical evaluation shows that the latter performs almost as well as state-of-the-art centralized techniques in realistic scenarios.
Tópico(s): Multi-Agent Systems and Negotiation
2013 - Springer Science+Business Media | Lecture notes in computer science
Marc Pujol, Manel López‐Béjar, M.T. Paramio,
The aim of this study was to evaluate the usefulness of the brilliant cresyl blue (BCB) test in the selection of more competent heifer oocytes for in vitro embryo production (IVEP). IVEP from selected BCB heifer oocytes was compared to IVEP from morphologically selected heifer (control group) and cow oocytes. BCB staining determines the activity of glucose-6-phosphate dehydrogenase (G6PD), an enzyme synthesized in growing oocytes but with less activity in grown oocytes. Six hundred and fifty seven heifer ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2003 - Elsevier BV | Theriogenology
Jordi Vilà, Martha Vargas, Joaquı́m Ruiz, Mateu Espasa, Marc Pujol, M Corachán, M. Teresa Jiménez de Anta, Joaquím Gascón,
Enteroaggregative Escherichia coli (EAggEC) isolates were identified as a cause of traveller's diarrhoea in 50 (9%) of 517 patients and their antimicrobial susceptibility was determined. Molecular epidemiological characterisation and investigation of the mechanisms of acquisition of quinolone resistance among nalidixic acid-resistant EAggEC strains was performed. Seventeen (34%) of 50 patients needed antimicrobial therapy, because of persistence of symptoms in nine cases and the severity of symptoms ...
Tópico(s): Salmonella and Campylobacter epidemiology
2001 - Microbiology Society | Journal of Medical Microbiology
Marc Pujol-Riqué, Francis Derouin, Albert García-Quintanilla, M Eugenia Valls, José M. Miró, M. T. Jiménez de Anta,
Summary The aims of the present study were to design an easy and sensitive DNA amplification method for detection of Toxoplasma gondii with low risk of accidental contamination, and to find a rapid method for purification of clinical samples containing potential inhibitors of the amplification reaction. With a pair of primers amplifying a 619-bp fragment of the B1 gene of this parasite it was possible to detect DNA equivalent, to 10 parasites. When a third primer was added to the same tube, sensitivity ...
Tópico(s): Parasitic Infections and Diagnostics
1999 - Microbiology Society | Journal of Medical Microbiology
Francisco Iván Caiza de la Cueva, Marc Pujol, T. Rigau, Sergi Bonet, Jordi Miró, M. Briz, Joan E. Rodríguez‐Gil,
To study the resistance of horse spermatozoa against hyperosmotic stress, cells were incubated in solutions of 600 to 4000 mOsm(undisturbed media). Then, semen was immediately placed into an iso-osmotic solution (disrupted media). Incubation in undisturbed media decreased sperm viability in an osmolarity- and temperature-dependent manner. Viability was further decreased in disrupted media, with the effect dependent upon the initial osmolarity of the media and on the temperature. Treatment with ouabain ...
Tópico(s): Reproductive Biology and Fertility
1997 - Elsevier BV | Theriogenology
Pascal Schmitt, Christine Garcia, V. Soulier, J.F. Pujol, Jean-Marc Péquignot,
Tyrosine hydroxylase (TH) protein was measured in the carotid body and adrenal gland of rats exposed to normobaric hypoxia (10% O2 in nitrogen) for 3, 7, 14 or 22 days. After 22 days of hypoxia, a gradual increase in TH protein content was observed in the carotid body and in the adrenal gland, reaching 168% and 148% of the normoxic controls, respectively. To determine if the increase in TH protein content in the carotid body could alter catecholamine biosynthesis, in vitro TH activity and catecholamine ...
Tópico(s): Muscle metabolism and nutrition
1992 - Elsevier BV | Journal of the Autonomic Nervous System
GianFranco Bottazzo, Toshiaki Hanafusa, Ricardo Pujol‐Borrell, Marc Feldmann,
Tópico(s): Urticaria and Related Conditions
1983 - Elsevier BV | The Lancet
Víctor Casamayor Pujol, Marc Morenza-Cinos, Bernat Gastón, Rafael Pous,
Maintaining an accurate and close to real time inventory of items is crucial for an efficient Supply Chain Management (SCM), which is one of the main pillars of successful business decisions in the retail market. Due to theft and misplacement, perpetual inventory systems are not enough for having an accurate picture of the current inventory. However, even if the retailer has implemented an RFID-based solution, manual inventories using handheld RFID readers tend to be tedious, expensive and inaccurate. ...
Tópico(s): Modular Robots and Swarm Intelligence
2020 - Elsevier BV | Computers in Industry
Marc Pujol-Riqué, Cristina Farriols Danés, M Eugenia Valls, M. Teresa Jiménez de Anta, Llorenç Quintó, Oriol Coll,
Averiguar si es necesario el cribado prenatal de la toxoplasmosis en nuestro hospital desde un punto de vista seroepidemiológico Se ha analizado retrospectivamente la prevalencia de IgG anti-T. gondii en 7.090 mujeres en edad fértil visitadas en el Hospital Clínic de Barcelona desde febrero de 1992 hasta abril de 1999. Se ha comprobado la asociación entre la seroprevalencia y las variables año, edad, lugar de nacimiento (provincia de Barcelona/otras provincias) y de residencia (urbano/rural) Se observó ...
Tópico(s): Cytomegalovirus and herpesvirus research
2000 - Elsevier BV | Medicina Clínica
Sam Ereira, Marine Pujol, Marc Guitart‐Masip, Raymond J. Dolan, Zeb Kurth‐Nelson,
Action is invigorated in the presence of reward-predicting stimuli and inhibited in the presence of punishment-predicting stimuli. Although valuable as a heuristic, this Pavlovian bias can also lead to maladaptive behaviour and is implicated in addiction. Here we explore whether Pavlovian bias can be overcome through training. Across five experiments, we find that Pavlovian bias is resistant to unlearning under most task configurations. However, we demonstrate that when subjects engage in instrumental ...
Tópico(s): Neural dynamics and brain function
2021 - Nature Portfolio | Scientific Reports
Jérôme Solassol, Marion Larrieux, Julie Leclerc, Vincent Ducros, Carole Corsini, Jean Chiésa, Pascal Pujol, Jean‐Marc Rey,
Lynch syndrome (LS) is the most frequent cause of hereditary colorectal cancer. A subset of patients with a history of LS shows no causal germline pathogenic alteration and are identified as having Lynch-like syndrome (LLS). Alu retrotransposons are the most abundant mobile DNA sequences in the human genome and have been associated with numerous human cancers by either disrupting coding regions or altering epigenetic modifications or splicing signals. We report a family first classified as having ...
Tópico(s): RNA modifications and cancer
2019 - Wiley | Human Mutation
Alexandre Prieur, Monica Cappellini, Guillaume Habif, Marie‐Paule Lefranc, Thibault Mazard, Eric Morency, Jean‐Marc Pascussi, Maud Flacelière, Nathalie Cahuzac, Bérengère Vire, Benjamin Dubuc, Amandine Durochat, Pierre Liaud, Jérémy Ollier, Caroline Pfeiffer, Sophie Poupeau, Véronique Saywell, Chris Planque, Éric Assenat, Fréderic Bibeau, Jean‐François Bourgaux, Pascal Pujol, A Sézeur, Marc Ychou, Dominique Joubert,
Purpose: Patients with metastatic colorectal cancer suffer from disease relapse mainly due to cancer stem cells (CSC). Interestingly, they have an increased level of blood progastrin, a tumor-promoting peptide essential for the self-renewal of colon CSCs, which is also a direct β-catenin/TCF4 target gene. In this study, we aimed to develop a novel targeted therapy to neutralize secreted progastrin to inhibit Wnt signaling, CSCs, and reduce relapses.Experimental Design: Antibodies (monoclonal and humanized) ...
Tópico(s): Digestive system and related health
2017 - American Association for Cancer Research | Clinical Cancer Research