Matteo Colina, Walter Zucchini, Giovanni Ciancìo, C Orzincolo, Francesco Trotta, Marcello Govoni,
Adult-onset Still's disease (AOSD) is a potentially crippling or life-threatening rare disease that may be self-limited, intermittent, and chronic. Clinical predictors of outcome are still lacking, as is information on the rate of progress of its chronic course. The main objective is to identify factors that improve our ability to predict the course of AOSD, and factors associated with the rate of progress of its chronic course. A comparison with the literature is included. A retrospective cohort ...
Tópico(s): Immune Cell Function and Interaction
2011 - Elsevier BV | Seminars in Arthritis and Rheumatism
G. Castellino, Roberta Capucci, Stella Bernardi, Melissa Padovan, S. Giacuzzo, Erica Pivato, Alfredo Patella, Francesco Trotta, Marcello Govoni,
To assess the outcome of pregnancy and disease flare or differentiation into well-defined connective tissue disease (CTD), in a cohort of pregnant patients with undifferentiated connective tissue disease (UCTD) and to compare these findings with those obtained from a population of non-pregnant women with UCTD.In total, 55 pregnancies (in 50 UCTD patients) were monitored from the positive pregnancy test until the sixth month after delivery. Likewise, during a 15-month timeframe, the incidence of flares ...
Tópico(s): Systemic Lupus Erythematosus Research
2011 - SAGE Publishing | Lupus
Katia Varani, Melissa Padovan, Fabrizio Vincenzi, Martina Targa, Francesco Trotta, Marcello Govoni, Pier Andrea Borea,
Abstract Introduction The reduction of the inflammatory status represents one of the most important targets in rheumatoid arthritis (RA). A central role of A 2A and A 3 adenosine receptors (ARs) in mechanisms of inflammation has been reported in different pathologies. The primary aim of this study was to investigate the A 2A and A 3 ARs and their involvement in RA progression measured by Disease Activity Score in 28 or 44 joints (DAS28 or DAS). Methods ARs were analyzed by saturation binding assays, ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2011 - BioMed Central | Arthritis Research & Therapy
Antonietta Gerarda Gravina, Raffaele Pellegrino, Tommaso Durante, Giovanna Palladino, Giuseppe Imperio, Giovanbattista D’Amico, Maria Consiglia Trotta, Marcello Dallio, Mario Romeo, Michele D’Amico, Alessandro Federico,
The melanocortin system is a complex set of molecular mediators and receptors involved in many physiological and homeostatic processes. These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory processes. In the latter context, the system has assumed importance in conditions of chronic digestive inflammation, such as inflammatory bowel diseases (IBD), in which numerous experiences have been accumulated in mouse models of colitis. Indeed, information ...
Tópico(s): Regulation of Appetite and Obesity
2023 - Multidisciplinary Digital Publishing Institute | Cells
Alessandra Vultaggio, Emanuele Vivarelli, Gianni Virgili, Ersilia Lucenteforte, Alessandro Bartoloni, Carlo Nozzoli, A Morettini, Andrea Berni, Danilo Malandrino, Oliviero Rossi, Francesca Nencini, Filippo Pieralli, Adriano Peris, Filippo Lagi, Giulia Scocchera, Michele Spinicci, Michele Trotta, Marcello Mazzetti, Paola Parronchi, Lorenzo Cosmi, Francesco Liotta, Paolo Fontanari, Alessio Mazzoni, Lorenzo Salvati, Enrico Maggi, Francesco Annunziato, Fabio Almerigogna, Andrea Matucci,
BackgroundThe early identification of patients at risk of clinical deterioration is of interest considering the timeline of COVID-19 after the onset of symptoms.ObjectiveThe aim of our study was to evaluate the usefulness of testing serum IL-6 and other serological and clinical biomarkers, to predict a short-term negative clinical course of patients with noncritical COVID-19.MethodsA total of 208 patients with noncritical COVID-19 pneumonia at admission were consecutively enrolled. Clinical and ...
Tópico(s): Sepsis Diagnosis and Treatment
2020 - Elsevier BV | The Journal of Allergy and Clinical Immunology In Practice
Elisa Gremese, S. Bernardi, Sara Bonazza, M. Nowik, Giusy Peluso, Alfonso Massara, Barbara Tolusso, L. Messuti, M. Carrie Miceli, A. Zoli, Francesco Trotta, Marcello Govoni, Gianfranco Ferraccioli,
The objective of this study was to determine whether BMI and gender could lead to a different response rate to anti-TNF agents in patients affected by axial SpA.One hundred and seventy patients with active axial SpA (defined as a BASDAI ≥ 4) treated with an anti-TNF agent [adalimumab (ADA), etanercept (ETA), infliximab (IFX)] were retrospectively evaluated. Patients were divided according to the baseline BMI as normal weight (BMI < 25), overweight (BMI 25-30) and obese (BMI ≥ 30). After 12 months of treatment ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2014 - Oxford University Press | Lara D. Veeken
Melissa Padovan, G. Castellino, Alessandra Bortoluzzi, Luisa Caniatti, Francesco Trotta, Marcello Govoni,
Tópico(s): Peripheral Neuropathies and Disorders
2010 - Springer Science+Business Media | Rheumatology International
Giovanni Ciancìo, Matteo Colina, R. La Corte, Andrea Lo Monaco, Francesco De Leonardis, Francesco Trotta, Marcello Govoni,
We report the use of nicotine-patch therapy on active mucocutaneous lesions of Behçet's disease (BD).Five BD ex-smoker patients with refractory active mucocutaneous manifestations were treated with nicotine patches for 6 months.Four out of five patients quickly responded to nicotine-patch therapy and experienced a complete regression of mucocutaneous lesions. Other manifestations of BD did not respond and new manifestations appeared during this treatment. One patient had no benefit from therapy but ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2009 - Oxford University Press | Lara D. Veeken
Matteo Colina, Giovanni Ciancìo, R. Garavini, Marta Helena Souza De Conti, Francesco Trotta, Marcello Govoni,
The aim of this study is to determine the effects of a combination treatment with etanercept and spa rehabilitation versus etanercept alone on function, disability and quality of life in a group of patients with active ankylosing spondylitis (AS). Sixty patients with AS underwent etanercept as suggested by ASAS/EULAR recommendations. As the clinical and laboratory conditions improved, 30 patients accepted the proposal of coupling the medical therapy with a 7-day rehabilitation program in a thermal ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2009 - SAGE Publishing | International Journal of Immunopathology and Pharmacology
G. Castellino, Melissa Padovan, Alessandra Bortoluzzi, Massimo Borrelli, Luciano Feggi, Maria Luisa Caniatti, Francesco Trotta, Marcello Govoni,
To assess the relationship between clinical picture and neuroimaging in patients affected by SLE with and without neuropsychiatric (NP) involvement.One hundred and seven SLE patients including 66 with NP involvement (NPSLE) with focal or diffuse presentation and 41 without underwent single photon emission computed tomography (SPECT) and MRI.After stratification for diffuse or focal NP involvement, in the 52 patients with diffuse presentation, abnormalities detected with MRI or SPECT did not differ ...
Tópico(s): Moyamoya disease diagnosis and treatment
2007 - Oxford University Press | Lara D. Veeken
Melissa Padovan, Luisa Caniatti, Francesco Trotta, Marcello Govoni,
To describe a rare association between rheumatoid arthritis (RA) and amyotrophic lateral sclerosis (ALS). Two new cases of patients with RA who developed amyotrophic lateral sclerosis (ALS), one receiving anti-TNFα agents, were reported. Only other five cases of this rare association have been previously described in literature. The simultaneous presence of the two diseases represents a difficult diagnostic challenge because RA may mimic some musculoskeletal symptoms of ALS. There is no evidence in ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2011 - Springer Science+Business Media | Rheumatology International
G. Castellino, Nicoletta Rizzo, Stella Bernardi, Francesco Trotta, Marcello Govoni,
To describe three cases of meningioma observed in a large cohort of 546 patients with systemic lupus erythematosus (SLE) followed at our Department in the last 15 years. We identified three cases of meningioma among 181 patients with SLE who underwent a brain magnetic resonance imaging (MRI) during their disease course (prevalence 1.65%). All three SLE cases were women with a disease onset at 47-, 18- and 42 -years-old, respectively. All patients presented neuropsychiatric (NP) symptoms and had an incidental ...
Tópico(s): Cerebral Venous Sinus Thrombosis
2009 - SAGE Publishing | Lupus
Maria Carla Re, Katia Marinelli, D Trotta, Alessia Monachetti, Marcello Tavio, Romana del Gobbo, Maria Rosaria Capobianchi, Stefano Menzo, Loredana Nicoletti, Fabio Magurano, Pietro E. Varaldo,
On 10 September 2011, a patient in his 50s was admitted to hospital in Ancona, Italy, after six days of high fever and no response to antibiotics. West Nile virus (WNV) infection was suspected after tests to determine the aetiology of the fever were inconclusive. On 20 September, WNV-specific IgM and IgG antibodies were detected in the patient’s serum. Genomic sequencing of the viral isolate showed that the virus belonged to WNV lineage 2.
Tópico(s): Malaria Research and Control
2011 - European Centre for Disease Prevention and Control | Eurosurveillance
Vincenzo Trotta, Federico C. F. Calboli, Marcello Ziosi, Sandro Cavicchi,
Genetically based body size differences are naturally occurring in populations of Drosophila melanogaster, with bigger flies in the cold. Despite the cosmopolitan nature of body size clines in more than one Drosophila species, the actual selective mechanisms controlling the genetic basis of body size variation are not fully understood. In particular, it is not clear what the selective value of cell size and cell area variation exactly is. In the present work we determined variation in viability, ...
Tópico(s): Genetic diversity and population structure
2007 - Springer Science+Business Media | BMC Evolutionary Biology
Vincenzo Trotta, Federico C. F. Calboli, Marcello Ziosi, Daniela Guerra, Maria Cristina Pezzoli, Jean R. David, Sandro Cavicchi,
Populations of Drosophila melanogaster show differences in many morphometrical traits according to their geographic origin. Despite the widespread occurrence of these differences in more than one Drosophila species, the actual selective mechanisms controlling the genetic basis of such variation are not fully understood. Thermal selection is considered to be the most likely cause explaining these differences. In our work, we investigated several life history traits (body size, duration of development, ...
Tópico(s): Neurobiology and Insect Physiology Research
2006 - Springer Science+Business Media | BMC Evolutionary Biology
Alfonso Massara, Sara Bonazza, G. Castellino, Luisa Caniatti, Francesco Trotta, Massimo Borrelli, Luciano Feggi, Marcello Govoni,
Objectives. To perform an observational retrospective cross-sectional case–control study to evaluate prevalence, clinical patterns and outcomes of CNS involvement in a large cohort of primary SS (pSS) patients. Methods. A total of 424 pSS patients, diagnosed according to the 2002 criteria proposed by the American–European Consensus Group, were checked for CNS involvement after exclusion of secondary causes. Demographic, clinical, seroimmunological data were compared between patients with and without ...
Tópico(s): Systemic Lupus Erythematosus Research
2010 - Oxford University Press | Lara D. Veeken
Melissa Padovan, Matteo Filippini, Anǵela Tincani, E. Lanciano, E Bruschi, Oscar Massimiliano Epis, Pietro Garau, Alessandro Mathieu, Eleonora Celletti, Leopoldo Giani, Paola Tomietto, Fabiola Atzeni, Piercarlo Sarzi‐Puttini, Francesca Zuliani, Salvatore De Vita, Francesco Trotta, Anastasio Grilli, Massimo Puoti, Marcello Govoni,
Rheumatoid arthritis (RA) with concomitant hepatitis B virus (HBV) infection represents a therapeutic challenge due to the risk of HBV reactivation under immunosuppressive treatment. To date there are few data coming from anecdotal case reports that concern HBV reactivation following treatment with abatacept. This observational retrospective study was aimed to assess the safety profile of abatacept in this particular clinical setting.Eleven Italian rheumatologic centers provided data from patients ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2015 - Wiley | Arthritis Care & Research
Paolo Colamussi, Francesco Trotta, R. Ricci, Corrado Cittanti, Marcello Govoni, Giovanna Barbarella, Melchiore Giganti, Gianluigi Bajocchi, Licia Uccelli, C. Trevisan, A Piffanelli,
The diagnosis of central nervous system (CNS) involvement appears to be a major problem in systemic lupus erythematosus (SLE), especially when the clinical signs are non-specific or neuroimaging is unremarkable. Two SLE patients with mild neuropsychiatric manifestations were studied with magnetic resonance imaging (MRI), single photon emission tomography (SPET) and localized proton magnetic resonance spectroscopy (H-1 MRS). MRI was normal in both patients. SPET revealed areas of hypoperfusion in both ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
1997 - Lippincott Williams & Wilkins | Nuclear Medicine Communications
Giovanni Ciancìo, Stefania Volpinari, Maria Fotinidi, Federica Furini, Ilaria Farina, Alessandra Bortoluzzi, Manuela Ferracin, Francesca Bandinelli, C Orzincolo, Francesco Trotta, Marcello Govoni,
Objective . To evaluate the involvement of the bursa located next to the head of the 5th metatarsal bone in patients with psoriatic arthritis (PsA) in comparison with the other seronegative spondyloarthritis (SpA). Methods . All patients with PsA seen during a period of 24 months were enrolled. The control group included healthy subjects and patients with the other SpA. All subjects underwent clinical and ultrasound (US) examination of the lateral surface of the 5th metatarsal. Results . 150 PsA patients ( ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2014 - Hindawi Publishing Corporation | BioMed Research International
Stefania Volpinari, Chiara Monaldini, J.G. Capone, Andrea Lo Monaco, R. La Corte, Francesco Trotta, Marcello Govoni,
Objective: To evaluate the prevalence of headache and its different patterns in patients with Behçet’s disease (BD) with and without neurological involvement and to investigate clinical correlations. Methods: Patients fulfilling the International Study Group criteria for Behçet disease (ISGc) were studied. Patients were invited to fill a “headache questionnaire”, which consisted of two sections: the first one included demographic and anamnestic data, family history for both headache and BD, disease ...
Tópico(s): Retinal and Optic Conditions
2011 - PAGEPress (Italy) | Reumatismo
Lorenzo Zammarchi, Tiziana Lazzarotto, Massimo Andreoni, Irene Campolmi, Lucia Pasquini, Mariarosaria Di Tommaso, Giuliana Simonazzi, Lina Rachele Tomasoni, Francesco Castelli, Luisa Galli, Beatrice Borchi, Pierangelo Clerici, Alessandro Bartoloni, Marcello Tavio, Michele Trotta,
BackgroundCongenital cytomegalovirus (CMV) infection is the leading infectious cause of neurological impairment for which, currently, there are no approved antenatal treatment options.ObjectivesThe aim of this article was to summarize the available evidence on the use of valacyclovir during pregnancy to prevent and treat congenital CMV infection and disease.SourcesTwo databases (PubMed and ClinicalTrial.gov) were reviewed.ContentSix relevant documents were identified, namely one observational study, ...
Tópico(s): Parvovirus B19 Infection Studies
2020 - Elsevier BV | Clinical Microbiology and Infection
Valentina Bagnari, Matteo Colina, Giovanni Ciancìo, Marcello Govoni, Francesco Trotta,
Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder characterised by high spiking fever, an evanescent salmon pink rash and arthritis, frequently accompanied by sore throat, myalgias, lymphadenopathies, splenomegaly and neutrophilic leukocytosis. Aetiology is still unknown, however, it seems that an important role is played by various infectious agents, which would act as triggers in genetically predisposed hosts. Diagnosis is a clinical one and may be lengthy because it requires ...
Tópico(s): Immune Cell Function and Interaction
2009 - Springer Science+Business Media | Rheumatology International
Matteo Colina, Marcello Govoni, Francesco Trotta,
Tópico(s): Parvovirus B19 Infection Studies
2008 - Springer Science+Business Media | Rheumatology International
Alberto Verrotti, L. Lobefalo, Tiziana Priolo, Marcello Rapinese, Daniela Trotta, G Morgese, P.E. Gallenga, Francesco Chiarelli,
The aims of our study were to evaluate whether deficits in color vision exist in epileptic adolescents, to study if monotherapy with valproic acid (VPA) and carbamazepine (CBZ) can affect color vision, and to determine the possible relationship between abnormal color vision tests and AEDs dosage and their serum concentrations.We examined 45 epileptic patients before the beginning of therapy and after 1 year of VPA or CBZ monotherapy and 40 sex- and age-matched healthy controls.Color vision was evaluated ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2004 - Elsevier BV | Seizure
R. La Corte, Gianluigi Bajocchi, A Potena, Marcello Govoni, Francesco Trotta,
OBJECTIVE--To determine the frequency and relative risk of bronchial hyperreactivity to methacholine in systemic sclerosis patients with or without associated Sjögren9s syndrome. METHODS--A prospective study of 56 patients with systemic sclerosis (42 with the diffuse and 14 with the limited variant; 24 with associated Sjögren9s syndrome), 57 with primary Sjögren9s syndrome, and 61 healthy controls. RESULTS--Bronchial hyperreactivity (BH) was present in 6.5% of the healthy controls, 25% of the systemic ...
Tópico(s): Lymphatic System and Diseases
1995 - BMJ | Annals of the Rheumatic Diseases
Alessandra Bortoluzzi, Melissa Padovan, Cristiano Azzini, Alessandro De Vito, Francesco Trotta, Marcello Govoni,
The objectives of this report are to assess the occurrence of microembolic signals (MES) detected by transcranial Doppler ultrasound (TCD) in systemic lupus erythematosus (SLE) patients with (NPSLE) and without (SLE) neuropsychiatric involvement, and to verify the correlation between MES, clinical characteristics, especially the patent foramen ovale (PFO), and the presence of punctuate T2-hyperintense white matter lesions (WMHLs) detected by conventional magnetic resonance imaging (cMRI).A TCD registration ...
Tópico(s): Advanced MRI Techniques and Applications
2015 - SAGE Publishing | Lupus
Melissa Padovan, G. Castellino, Marcello Govoni, Francesco Trotta,
Tópico(s): Spondyloarthritis Studies and Treatments
2006 - Springer Science+Business Media | Rheumatology International
GianMarco Giorgetti, Giovanni Brandimarte, F. Fabiocchi, Salvatore Ricci, Paolo Flamini, Giancarlo Sandri, M.C. Trotta, Walter Elisei, Antônio Penna, P.G. Lecca, Marcello Picchio, Antonio Tursi,
The term “microbiota” means genetic inheritance associated with microbiota, which is about 100 times larger than the guest. The tolerance of the resident bacterial flora is an important key element of immune cell function. A key role in the interaction between the host and the microbiota is played by Paneth cell, which is able to synthesize and secrete proteins and antimicrobial peptides, such as α / β defensins, cathelicidin, 14 β -glycosidases, C-type lectins, and ribonuclease, in response to various ...
Tópico(s): Pediatric health and respiratory diseases
2015 - Hindawi Publishing Corporation | Journal of Immunology Research
Matteo Colina, Letizia Penolazzi, Martina di Ciano, Elisabetta Lambertini, Giovanni Ciancìo, C Orzincolo, Francesco Trotta, Marcello Govoni, Roberta Piva,
The pathogenesis of ankylosing spondylitis (AS) is mainly characterized by inflammation in the axial skeleton initially dominated by mononuclear cell infiltrates and by increased number of osteoclasts (OCs) combined by an enhanced osteoblast activity leading to excessive bone apposition. The complexity of AS pathogenetic pathways has so far prevented the development of an adequate definitive therapy. Among the most studied targets for assessing therapeutic effectiveness, there are the OCs, the primary ...
Tópico(s): Dermatological and Skeletal Disorders
2013 - Elsevier BV | Biomedicine & Preventive Nutrition
Francesco Trotta, L Dovigo, Marcello Govoni, Maria Rosaria Tola, D Chiarini, R Tamarozzi, Paolo Colamussi, A Piffanelli,
Tópico(s): Systemic Lupus Erythematosus Research
1997 - Elsevier BV | European Journal of Internal Medicine