J. Andrés Díaz Pace, Marcelo Campo,
... Argentina UNICEN University, Tandil, Buenos Aires, ArgentinaView Profile , Marcelo R. Campo UNICEN University, Tandil, Buenos Aires, Argentina UNICEN University, ...
Tópico(s): Software Engineering Research
2001 - Association for Computing Machinery | Communications of the ACM
Produção Nacional
Revisado por pares
Edenir Inêz Palmero, Silvana G. P. Campos, Marcelo Campos, Naiara Correa Nogueira-de-Souza, Ismael Dale C. Guerreiro, André Lopes Carvalho, Márcia Maria Chiquitelli Marques,
MicroRNAs are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20-23 nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, ...
Tópico(s): Cancer-related molecular mechanisms research
2011 - Brazilian Society of Genetics | Genetics and Molecular Biology
Eduardo Gallardo‐Toledo, Andreas Tapia-Arellano, Freddy Célis, Tomer Sinai, Marcelo Campos, Marcelo J. Kogan, Amnon Sintov,
The presence of the blood–brain barrier (BBB) limit gold nanoparticles (GNP) accumulation in central nervous system (CNS) after intravenous (IV) administration. The intranasal (IN) route has been suggested as a good strategy for circumventing the BBB. In this report, we used gold nanoprisms (78 nm) and nanospheres (47 nm), of comparable surface areas (8000 vs 7235 nm2) functionalized with a polyethylene glycol (PEG) and D1 peptide (GNPr-D1 and GNS-D1, respectively) to evaluate their delivery to the CNS after ...
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2020 - Elsevier BV | International Journal of Pharmaceutics
Patricia Baré, Ivana Massud, Cecilia Parodi, Liliana Belmonte, Gabriel García, Marcelo Campos Nebel, Marcelo Corti, Miguel Tezanos Pinto, R. Bianco, M Bracco, Rodolfo Campos, Beatriz Ruibal Ares,
In order to investigate hepatitis C virus (HCV) persistence and replication in peripheral blood mononuclear cells (PBMC) from a group of haemophilic individuals, HCV production and release to PBMC culture supernatants (SNs) from HCV singly infected patients and HIV/HCV co-infected patients was studied. HCV RNA+ SNs were found more frequently from HIV/HCV co-infected individuals (89.5 %) with poor reconstitution of their immune status than from singly HCV-infected patients (57 %) or from HIV/HCV co-infected ...
Tópico(s): Systemic Lupus Erythematosus Research
2005 - Microbiology Society | Journal of General Virology
Produção Nacional
Revisado por pares
Ricardo Santos de Oliveira, Marcelo Campos Moraes Amato, Marcelo Volpon Santos, Gustavo Novelino Simão, Hélio Rubens Machado,
Tópico(s): Spinal Fractures and Fixation Techniques
2007 - Springer Science+Business Media | Child s Nervous System
Produção Nacional
Revisado por pares
Karen Bolaños, Freddy Célis, C. Garrido, Marcelo Campos, Fanny Guzmán, Marcelo J. Kogan, Eyleen Araya,
The photothermal conversion efficiency of AuNPr–PEG after albumin corona formation and the effect of irradiation on the protein structure were evaluated.
Tópico(s): Nanoplatforms for cancer theranostics
2020 - Royal Society of Chemistry | Journal of Materials Chemistry B
Pedro Jara-Guajardo, Pablo Cabrera, Freddy Célis, Mónica Soler, Isadora Berlanga, Nicole Parra‐Muñoz, Gerardo Acosta, Fernando Alberício, Fanny Guzmán, Marcelo Campos, Alejandra Álvarez, Francisco Morales-Zavala, Marcelo J. Kogan,
The early detection of the amyloid beta peptide aggregates involved in Alzheimer’s disease is crucial to test new potential treatments. In this research, we improved the detection of amyloid beta peptide aggregates in vitro and ex vivo by fluorescence combining the use of CRANAD-2 and gold nanorods (GNRs) by the surface enhancement fluorescence effect. We synthetized GNRs and modified their surface with HS-PEG-OMe and HS-PEG-COOH and functionalized them with the D1 peptide, which has the capability ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
2020 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Produção Nacional
Revisado por pares
L. Castro, Igor Lima Maldonado, I Campos, Bruno Milen Varjão, Ana Luiza Dias Ângelo, Rodrigo Abensur Athanazio, Marcelo Campos Barbetta, A. Ramos, J.B. Fregoneze, E. de Castro e Silva,
In the present study, we investigated in rats the effect of third ventricle injections of 1-(3-chlorophenyl)piperazine (mCPP), a 5-HT2 receptor agonist, on water intake induced by three different physiological stimuli: fluid deprivation, acute salt load and hypovolemia. Injections of mCPP in the doses of 80 and 160 nmol/rat were able to decrease water intake in all three conditions studied. Third ventricle injections of mCPP (160 nmol/rat) were no longer able to diminish water intake in the groups ...
Tópico(s): Neuropeptides and Animal Physiology
2002 - Elsevier BV | Pharmacology Biochemistry and Behavior
Produção Nacional
Sajjad Hussain, Hammad Khan, Nadeem A. Khan, Saima Gul, Fazal Wahab, Khurram Imran Khan, Shakeel Zeb, Sabir Khan, Ali Baddouh, Muhammad Shozab Mehdi, Ariane Fiorese Maldonado, Marcelo Campos,
This study explores the modeling and optimization of electrochemical influencing parameters on the sunset yellow (SSY) decontamination process by response surface methodology (RSM). Four factors historical data design which include time (X1), pH 03–10 (X2), NaCl concentration 0.02–0.08 M (X3) and current densities 2.5 to 10 mA cm −2 (X4) was employed to correlate the factors with dye removal and electrical energy consumption as responses. Stepwise regression analysis of first order, second order, cubic ...
Tópico(s): Electrochemical Analysis and Applications
2021 - Elsevier BV | Environmental Technology & Innovation
Marcelo Campos Moraes Amato, W G Totty, Louis A. Gilula,
Fifty-six cases of spondylolysis were encountered in 1500 lumbar spine reports reviewed. The frequency of detecting isthmus defects on anteroposterior (AP), lateral, 45-degree right and left oblique, 30-degree up-angled AP, and collimated lateral views was determined. The collimated lateral view showed the largest number of pars defects, 84% of cases. The 30-degree up-angled AP view was more sensitive than the AP view, showing 55% versus 32% of cases. A previously unreported sign of spondylolysis, ...
Tópico(s): Spinal Fractures and Fixation Techniques
1984 - Radiological Society of North America | Radiology
Marco Crasso, Alejandro Zunino, Marcelo Campo,
Tópico(s): Semantic Web and Ontologies
2009 - Springer Science+Business Media | Information Systems Frontiers
Agustin Casamayor, Daniela Godoy, Marcelo Campo,
Early detection of non-functional requirements (NFRs) is crucial in the evaluation of architectural alternatives starting from initial design decisions. The application of supervised text categorization strategies for requirements expressed in natural language has been proposed in several works as a method to help analysts in the detection and classification of NFRs concerning different aspects of software. However, a significant number of pre-categorized requirements are needed to train supervised ...
Tópico(s): Web Data Mining and Analysis
2009 - Elsevier BV | Information and Software Technology
Produção Nacional
Revisado por pares
O artigo relaciona os processos e efeitos entre meios de comunicação de massa e a proposição de políticas públicas sobre o tema da redução da maioridade penal no Brasil. O objetivo é analisar como dois crimes de grande repercussão pública, ocorridos em 2003 e 2007, mobilizaram a tramitação das Propostas de Emenda à Constituição (PEC's) favoráveis à redução da maioridade penal na Câmara dos Deputados. O artigo analisa as matérias veiculadas pela Revista Veja e o Jornal Folha de S.Paulo nos períodos ...
Tópico(s): Youth, Drugs, and Violence
2009 - UNIVERSIDADE ESTADUAL DE CAMPINAS | Opinião Pública
Agustin Casamayor, Analı́a Amandi, Marcelo Campo,
Collaborative learning environments provide a set of tools for students acting in groups to interact and accomplish an assigned task. In this kind of systems, students are free to express and communicate with each other, which usually lead to collaboration and communication problems that may require the intervention of a teacher. In this article, we introduce an intelligent agent approach to assist teachers through monitoring participations made by students within a collaborative distance learning ...
Tópico(s): Intelligent Tutoring Systems and Adaptive Learning
2009 - Elsevier BV | Computers & Education
Produção Nacional
Revisado por pares
Ricardo Santos de Oliveira, Marcelo Campos Moraes Amato, G. N. Simão, Daniel Giansante Abud, E. B. Avidago, C. M. Specian, Hélio Rubens Machado,
Moyamoya disease (MMD) is an uncommon cerebrovascular disorder characterized by progressive stenosis of the terminal portion of the internal carotid artery and its main branches. Direct and indirect bypass techniques have been devised with the aim of promoting neoangiogenesis. The current study aimed to investigate the role of multiple cranial burr hole (MCBH) operations in the prevention of cerebral ischemic attacks in children with MMD. Seven children suffering from progressive MMD were submitted ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2009 - Thieme Medical Publishers (Germany) | Neuropediatrics
Produção Nacional
Revisado por pares
Gervásio Henrique Bechara, Matias Pablo Juán Szabó, W. V. ALMEIDA FILHO, Juliana Noda Bechara, Ricardo José Garcia Pereira, J. E. GARCIA, Marcelo Campos Pereira,
A bstract : This study was conducted in October 1998 and November 1999 in the Emas National Park (131,868 ha), a savanna‐type cerrado region situated in the far south of Goias State, Brazil, near the geographic center of South America (15°‐23° S; 45°‐55° W). Animals were captured with the aid of nets and anesthetized (15 mg/kg ketamine + 1 mg/kg xylasine) in order to collect ticks for identification and to establish laboratory colonies. They included giant anteaters ( Myrmecophaga tridactyla ) ( n = 4 ) and yellow ...
Tópico(s): Mosquito-borne diseases and control
2002 - Wiley | Annals of the New York Academy of Sciences
Marcelo Campo, Andrés Díaz Pace, Mario Zito,
Abstract In this article, we present an approach to architecture‐driven design of object‐oriented frameworks based on the notion of object‐oriented materialization of architectural styles. This approach leads us to the development of the proto‐framework concept, which is a new denomination for an object‐oriented framework that provides the essential basis to build other frameworks that adopt an underlying architectural design derived from non‐object‐oriented styles. In this context, we describe ...
Tópico(s): Advanced Software Engineering Methodologies
2002 - Wiley | Software Practice and Experience
Produção Nacional
Revisado por pares
Benedicto Oscar Colli, Carlos Gilberto Carlotti, João Alberto Assirati, Hélio Rubens Machado, Marcelo Moraes Valênça, Marcelo Campos Moraes Amato,
Cysticercosis is the most frequent parasitosis of the central nervous system. Although anticysticercal drugs have proven efficient in some cases, many patients with NCC require palliative, occasionally curative, surgical procedures. The authors analyzed the data and prognostic factors obtained during the follow-up period (range 1-255 months, median 38 months) in 160 patients with cerebral cysticercosis who underwent surgical treatment.Different surgical approaches were indicated to control increased ...
Tópico(s): Genetic and Kidney Cyst Diseases
2002 - American Association of Neurological Surgeons | Neurosurgical FOCUS
Produção Nacional
Revisado por pares
L. Castro, Rodrigo Abensur Athanazio, Marcelo Campos Barbetta, Ana Cláudia Ramos, Ana Luiza Dias Ângelo, Igor Campos, Bruno Milen Varjão, Hilda Silva Ferreira, J.B. Fregoneze, Emilio de Castro e Silva,
Tópico(s): Neuropeptides and Animal Physiology
2003 - Elsevier BV | Brain Research
Produção Nacional
Revisado por pares
Yves Sabbagh, Guy Boileau, Marcelo Campos, Adriana K. Carmona, Harriet S. Tenenhouse,
The PHEX gene that is mutated in patients with X-linked hypophosphatemia (XLH) encodes a protein homologous to the M13 family of zinc metallopeptidases. The present study was undertaken to assess the impact of nine PHEX missense mutations on cellular trafficking, endopeptidase activity, and protein conformation. Secreted forms of wild-type and mutant PHEX proteins were generated by PCR mutagenesis; these included C85R, D237G, Y317F, G579R, G579V, S711R, A720T, and F731Y identified in XLH patients, ...
Tópico(s): Bone health and treatments
2003 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Produção Nacional
Revisado por pares
Matias Pablo Juán Szabó, Marcelo B. Labruna, Marcelo Campos Pereira, José Maurício Barbanti Duarte,
The lake from Porto-Primavera hydroelectric power station inundated an area of 2,200 km2 at the border of São Paulo and Mato-Grosso do Sul States, Brazil. Infestations by ticks were evaluated on 135 marsh deer, Blastocerus dichotomus (Illiger), captured before and after inundation. Ticks were collected for identification, and infestation level of animals was assessed by scoring. Deer were divided into four groups according to capture location and temporal relation to the inundation. Groups 1, 2, ...
Tópico(s): Study of Mite Species
2003 - Oxford University Press | Journal of Medical Entomology
Matias Pablo Juán Szabó, Marcelo B. Labruna, Marcelo Campos Pereira, José Maurício Barbanti Duarte,
Tópico(s): Study of Mite Species
2003 - Oxford University Press | Journal of Medical Entomology
Produção Nacional
Revisado por pares
Marcelo Campos, Constance COUTURE, Izaura Yoshico Hirata, María A. Juliano, Thomas P. Loisel, Philippe Crine, Luiz Juliano, Guy Boileau, Adriana K. Carmona,
The PHEX gene (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) encodes a protein (PHEX) with structural homologies to members of the M13 family of zinc metallo-endopeptidases. Mutations in the PHEX gene are responsible for X-linked hypophosphataemia in humans. However, the mechanism by which loss of PHEX function results in the disease phenotype, and the endogenous PHEX substrate(s) remain unknown. In order to study PHEX substrate specificity, combinatorial fluorescent- ...
Tópico(s): Peptidase Inhibition and Analysis
2003 - Portland Press | Biochemical Journal
Alejandro Zunino, Marcelo Campo,
Tópico(s): Logic, Reasoning, and Knowledge
2008 - Elsevier BV | Expert Systems with Applications
Produção Nacional
Revisado por pares
Alessandro de Moura Almeida, Almir Galvão Vieira Bitencourt, Nedy Maria Branco Cerqueira Neves, Flávia Branco Cerqueira Serra Neves, Marina da Rocha Lordelo, Kleuber Moreira Lemos, Geila Ribeiro Nuñez, Marcelo Campos Barbetta, Rodrigo Abensur Athanazio, Antônio Nery-Filho,
OBJETIVOS: Avaliar o interesse e o conhecimento sobre ética médica e bioética na graduação médica. MÉTODOS: Estudo transversal e descritivo. Foram utilizados dois questionários auto-aplicáveis, um para docentes e outro para discentes, com questões sobre o interesse em ética médica e bioética e conhecimento sobre o Código de Ética Médica (CEM). RESULTADOS: Foram avaliados 101 professores e 331 estudantes. O CEM brasileiro foi lido por 86,2% dos professores e 100% dos alunos. A importância dada à disciplina ...
Tópico(s): Patient Dignity and Privacy
2008 - Associção Brasileira de Educação Médica | Revista Brasileira de Educação Médica
Alfredo Teyseyre, Marcelo Campo,
Software visualization studies techniques and methods for graphically representing different aspects of software. Its main goal is to enhance, simplify and clarify the mental representation a software engineer has of a computer system. During many years, visualization in 2D space has been actively studied, but in the last decade, researchers have begun to explore new 3D representations for visualizing software. In this article, we present an overview of current research in the area, describing several ...
Tópico(s): Software Engineering Techniques and Practices
2008 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Visualization and Computer Graphics
Marco Crasso, Alejandro Zunino, Marcelo Campo,
Web services have acquired enormous popularity among software developers. This popularity has motivated developers to publish a large number of Web service descriptions in UDDI registries. Although these registries provide search facilities, they are still rather difficult to use and often require service consumers to spend too much time manually browsing and selecting service descriptions. This paper presents a novel search method for Web services called WSQBE that aims at both easing query specification ...
Tópico(s): Semantic Web and Ontologies
2008 - Elsevier BV | Science of Computer Programming
Produção Nacional
Revisado por pares
Juliano P. Nakashima, Célia M. Viégas, Ana L. Fassizoli, Marcelo Campos Rodrigues, Leonardo A.G. Chamon, João H.C. Silva, Fernando Luiz Dias, Carlos M. Araújo,
The role of postoperative radiotherapy (PORT) in head and neck mucosal melanomas (HNMM) is not yet clearly defined. The aim of this study is to report the 21-year experience of the Brazilian National Cancer Institute in such treatment.From January 1983 to December 2003, 31 patients with confirmed histological diagnosis of HNMM underwent treatment at the Brazilian National Cancer Institute. Of these, 20 received radical treatment with surgery alone (8 patients--group 1) or surgery and PORT (12 patients-- ...
Tópico(s): Cancer Diagnosis and Treatment
2008 - Karger Publishers | ORL
Marco Crasso, Alejandro Zunino, Marcelo Campo,
A Web service is a Web accessible software that can be published, located and invoked by using standard Web protocols. Automatically determining the category of a Web service, from several pre-defined categories, is an important problem with many applications such as service discovery, semantic annotation and service matching. This paper describes AWSC (Automatic Web Service Classification), an automatic classifier of Web service descriptions. AWSC exploits the connections between the category of ...
Tópico(s): Text and Document Classification Technologies
2008 - Asociación Española para la Inteligencia Artificial | INTELIGENCIA ARTIFICIAL
Produção Nacional
Revisado por pares
Marcelo Campos, Elizabeth Orika Ono, Carmen Sílvia Fernandes Boaro, João Domingos Rodrigues,
Growth analysis of soybean plants treated with plant growth regulators. This work aimed to verify the effect of plant growth regulators on soybean plant growth and chlorophyll content. In an experiment carriedout in a greenhouse, soybean plants were cultivated (Glycine max (L.) Merrill cv. BRS-184) in 10-liter pots containing soil from the arable layer, corrected and fertilized according to the soil analysis. The treatments used were: control; GA3 100mg.L-1; BAP 100mg.L-1; IBA 100mg.L-1; Stimulate® ( ...
Tópico(s): Plant and animal studies
2008 - UNIVERSIDADE FEDERAL DE SANTA CATARINA | Biotemas