Flora Giudicepietro, M. Orazi, G. Scarpato, Rosario Peluso, Luca D’Auria, P. Ricciolino, D. Lo Bascio, Antonietta M. Esposito, G. Borriello, M. Capello, Antonio C. Caputo, C. Buonocunto, W. De Cesare, G. Vilardo, M. Martini,
... Ricciolino, Domenico Lo Bascio, Antonietta M. Esposito, Giuseppe Borriello, Marco Capello, Antonio Caputo, Ciro Buonocunto, Walter De Cesare, ...
Tópico(s): Landslides and related hazards
2010 - Seismological Society of America | Seismological Research Letters
Silvia Catena, Federica Turrini, Raffaella Boggia, Matilde Borriello, Marco Gardella, Paola Zunin,
The study is focused on the effect of different cooking conditions on the antioxidant content, particularly anthocyanins, of Oryza sativa L. 'Violet Nori', a new black rice cultivar. 10 different cooking tests were performed. The selected cooking conditions allowed to evaluate the effect of boiling, roasting, oven cooking, risotto cooking, and oriental cooking. The total anthocyanins amounts were evaluated by both a spectrophotometric pH differential method and High-Performance Liquid Chromatography ( ...
Tópico(s): Fermentation and Sensory Analysis
2019 - Springer Science+Business Media | European Food Research and Technology
Maria Verde, Alberto De Bonis, Francesco D’Uva, Vincenza Guarino, Francesco Izzo, Concetta Rispoli, Giovanni Borriello, Marco Giglio, Stefano Iavarone, Vincenzo Morra,
The focus of this work is the archaeometric investigation of ceramic wasters found in a dump in the workshop area of Cumae that are mostly represented by important production indicators of pottery produced in the Augustean-Tiberian period. The fragments belong to different ceramic classes and productions, such as: pompeian red ware, common cookwares, parts of kiln vault, thin-walled pottery, terra sigillata, large container, bar, and graue Platten. Provenance of the raw materials used for each ceramic ...
Tópico(s): Conservation Techniques and Studies
2022 - Elsevier BV | Journal of Archaeological Science Reports
Giovanni Pagano, Giuseppe Castello, Marialuisa Gallo, Ilaria Borriello, Marco Guida,
A series of studies investigated the toxicities of tannery-derived complex mixtures, i.e. vegetable tannin (VT) from Acacia sp. or phenol-based synthetic tannin (ST), and wastewater from tannin-based vs. chromium-based tanneries. Toxicity was evaluated by multiple bioassays including developmental defects and loss of fertilization rate in sea urchin embryos and sperm ( Paracentrotus lividus and Sphaerechinus granularis), and algal growth inhibition ( Dunaliella tertiolecta and Selenastrum capricornutum). ...
Tópico(s): Microplastics and Plastic Pollution
2008 - SAGE Publishing | Dose-Response
Produção Nacional
Revisado por pares
Geraldo Duarte, Antônio Fernandes Moron, Artur Timerman, César Eduardo Fernandes, Coríntio Mariani Neto, Gutemberg Leão de Almeida Filho, Heron Werner, Hilka Flavia Barra do Espírito Santo, João Alfredo Piffero Steibel, João Bortoletti Filho, Juvenal Barreto Borriello de Andrade, Marcelo Burlá, Marcos Felipe Silva de Sá, Newton Eduardo Busso, Paulo César Giraldo, Renato Augusto Moreira de Sá, Renato Passini, Rosiane Mattar, Rossana Pulcineli Vieira Francisco,
From the discovery of the Zika virus (ZIKV) in 1947 in Uganda (Africa), until its arrival in South America, it was not known that it would affect human reproductive life so severely. Today, damage to the central nervous system is known to be multiple, and microcephaly is considered the tip of the iceberg. Microcephaly actually represents the epilogue of this infection's devastating process on the central nervous system of embryos and fetuses. As a result of central nervous system aggression by the ...
Tópico(s): Virology and Viral Diseases
2017 - Thieme Medical Publishers (Germany) | Revista Brasileira Ginecologia e Obstetrícia
Stefania Butini, Giuseppe Campiani, Marianna Borriello, Sandra Gemma, Alessandro Panico, Marco Persico, Bruno Catalanotti, Sindu Ros, Margherita Brindisi, Marianna Agnusdei, Isabella Fiorini, Vito Nacci, Ettore Novellino, Tatyana Belinskaya, Ashima Saxena, Caterina Fattorusso,
Protein conformational fluctuations are critical for biological functions, although the relationship between protein motion and function has yet to be fully explored. By a thorough bioinformatics analysis of cholinesterases (ChEs), we identified specific hot spots, responsible for protein fluctuations and functions, and those active-site residues that play a role in modulating the cooperative network among the key substructures. This drew the optimization of our design strategy to discover potent ...
Tópico(s): Medicinal Plants and Neuroprotection
2008 - American Chemical Society | Journal of Medicinal Chemistry
Emanuele Rinninella, Marco D’Angelo, Raffaele Borriello, Tiziano Galasso, Marco Cintoni, Pauline Raoul, Michele Impagnatiello, B.E. Annicchiarico, Antonio Gasbarrini, Maria Cristina Mele,
Background: Refeeding syndrome (RS) is a neglected, potentially fatal syndrome that occurs in malnourished patients undergoing rapid nutritional replenishment after a period of fasting. The American Society for Parenteral and Enteral Nutrition (ASPEN) recently released new criteria for RS risk and diagnosis. Real-life data on its incidence are still limited. Methods: We consecutively enrolled patients admitted to the Internal Medicine and Gastroenterology Unit of our center. The RS risk prevalence ...
Tópico(s): Diet and metabolism studies
2022 - Multidisciplinary Digital Publishing Institute | Nutrients
Sebastiano Bucello, Pietro Annovazzi, Paolo Ragonese, Marta Altieri, Valeria Barcella, Roberto Bergamaschi, Alessia Bianchi, Giovanna Borriello, Maria Chiara Buscarinu, Graziella Callari, Marco Capobianco, Fioravante Capone, Paola Cavalla, Rosella Cavarretta, Antonio Cortese, Giovanna De Luca, Massimiliano Di Filippo, Vincenzo Dattola, Roberta Fantozzi, Elisabetta Ferraro, Maria Maddalena Filippi, Claudio Gasperini, Luigi Maria Grimaldi, Doriana Landi, Marianna Lo Re, Giulia Mallucci, Paolo Manganotti, Girolama Alessandra Marfia, Massimiliano Mirabella, Paola Perini, Marco Pisa, Sabrina Realmuto, Margherita Russo, Valentina Tomassini, Valentina Torri Clerici, Mauro Zaffaroni, Cristina Zuliani, Sofia Zywicki, Massimo Filippi, Luca Prosperini,
Tópico(s): Fungal Plant Pathogen Control
2021 - Springer Science+Business Media | Journal of Neurology
Alessandro Federico, Elena D’Aiuto, Francesco Borriello, Giusi Barra, Antonietta Gerarda Gravina, Marco Romano, Raffaele De Palma,
Obesity is increasingly being recognized as a risk factor for a number of benign and malignant gastrointestinal conditions.However, literature on the underlying pathophysiological mechanisms is sparse and ambiguous.There is compelling evidence that both overnutrition and undernutrition negatively interfere with the immune system.Overnutrition has been found to increase susceptibility to the development of inflammatory diseases, autoimmune diseases and cancer.In the regulation of immune and inflammatory ...
Tópico(s): Lipid metabolism and disorders
2010 - Baishideng Publishing Group | World Journal of Gastroenterology
Debora Bencivenga, Francesco Arcadio, Angelantonio Piccirillo, Marco Annunziata, Fulvio Della Ragione, Nunzio Cennamo, Adriana Borriello, Luigi Zeni, Luigi Guida,
Numerous pieces of evidence demonstrate that oxidative stress impairs biological functions, speeds up aging, and has a role in a variety of human diseases, including systemic and oral inflammatory disorders, and even cancer. Therefore, technologies providing accurate measures of oxidative stress indicators or biomarkers appear essential in the identification/prevention of such diseases, and in their management. Particularly advantageous is the employement of point-of-care tests based on affordable ...
Tópico(s): Advanced Chemical Sensor Technologies
2023 - Elsevier BV | Free Radical Biology and Medicine
R. Gray Huffman, Andrew Leduc, Christoph Wichmann, Marco Di Gioia, Francesco Borriello, Harrison Specht, Jason Derks, Saad Khan, Luke Khoury, Edward Emmott, Aleksandra A. Petelski, David H. Perlman, Jürgen Cox, Ivan Zanoni, Nikolai Slavov,
Major aims of single-cell proteomics include increasing the consistency, sensitivity and depth of protein quantification, especially for proteins and modifications of biological interest. Here, to simultaneously advance all these aims, we developed prioritized Single-Cell ProtEomics (pSCoPE). pSCoPE consistently analyzes thousands of prioritized peptides across all single cells (thus increasing data completeness) while maximizing instrument time spent analyzing identifiable peptides, thus increasing ...
Tópico(s): Mass Spectrometry Techniques and Applications
2023 - Nature Portfolio | Nature Methods
Produção Nacional
Revisado por pares
Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Vincenzo Brescia Morra, Maria Trojano, Gioacchino Tedeschi, Gıancarlo Comı, Mario Alberto Battaglia, Francesco Patti, Yára Dadalti Fragoso, Sedat Şen, Aksel Sıva, Roberto Furlan, Marco Salvetti, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, R. Allegri, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, Mario Alberto Battaglia, A. Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Morra Vincenzo Brescia, Giampaolo Brichetto, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Caniatti, Roberto Cantello, Marco Capobianco, Ruggero Capra, Rocco Capuano, Luca Carmisciano, Patrizia Carta, Paola Cavalla, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Grazia Chisari, Raffaella Clerici, Marinella Clerico, Eleonora Cocco, Gaia Cola, Gıancarlo Comı, Paolo Confalonieri, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Cinzia Cordioli, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d’Ambrosio, Emanuele D’Amico, Maura Danni, Alessia d’Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Rossi, Nicola De Stefano, Marco Della Cava, Mario Di Napoli, Alessia Di Sapio, Renato Docimo, A Dutto, Luana Evangelista, Salvatore Fanara, Diana Ferraro, Maria Teresa Ferrò, Massimo Filippi, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Roberto Furlan, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Paolo Immovilli, Daniele Imperiale, María Teresa Infante, Matilde Inglese, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Doriana Landi, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, Rita L’Episcopo Maria, Serena Leva, Giuseppe Liberatore, Marianna Lo Re, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Mancinelli, Luca Mancinelli, Paolo Manganotti, Teresa Giorgia Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, Alessandra Girolama Marfia, F. Marinelli, Alessandro Marti, Filippo Martinelli Boneschi, Federco Masserano Zoli, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Lucia Moiola, Sara Montepietra, Margherita Monti Bragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile‐Orazio, Agostino Nozzolillo, Marco Onofrj, Doriana Landi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Francesco Patti, Elisabetta Pedrazzoli, Paola Perini, Ilaria Pesci, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M. Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Marta Radaelli, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Marco Salvetti, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Cinzia Scandellari, Ilaria Scarano Giuditta, Valentina Scarano, Irene Schiavetti, Valentina Schillaci, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Maria Pia Sormani, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Laura Emanuela Susani, Giulietta Tabiadon, Francesco Teatini, Gioacchino Tedeschi, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Trojano, Maria Consiglia Trotta, G. Turano, Monica Ulivelli, Valentino Manzo, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Antonio Zito, Luigi Zuliani,
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available.To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test.We evaluated the association between positive serological ...
SAGE Publishing | Multiple Sclerosis Journal
Maria Pia Sormani, Irene Schiavetti, Luca Carmisciano, Cinzia Cordioli, Massimo Filippi, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Nicola De Rossi, Giampaolo Brichetto, Eleonora Cocco, Cinzia Scandellari, Paola Cavalla, Ilaria Pesci, Antonio Zito, Paolo Confalonieri, Girolama Alessandra Marfia, Paola Perini, Matilde Inglese, Maria Trojano, Vincenzo Brescia Morra, Gioacchino Tedeschi, Gıancarlo Comı, Mario Alberto Battaglia, Francesco Patti, Marco Salvetti, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, Beatrice Maria Allegri Rossi, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, A. Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Caniatti, Roberto Cantello, Ruggero Capra, Rocco Capuano, Patrizia Carta, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Grazia Chisari, Raffaella Clerici, Marinella Clerico, Gaia Cola, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d’Ambrosio, Emanuele D’Amico, Maura Danni, Alessia d’Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Stefano, Marco Della Cava, Mario Di Napoli, Alessia Di Sapio, Renato Docimo, A Dutto, Luana Evangelista, Salvatore Fanara, Ferraro Diana, Maria Teresa Ferrò, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Roberto Furlan, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Daniele Imperiale, María Teresa Infante, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Doriana Landi, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, M.R. L'Episcopo, Serena Leva, Giuseppe Liberatore, Marianna Lo Re, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Mancinelli, Luca Mancinelli, Paolo Manganotti, Giorgia Teresa Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, F. Marinelli, Alessandro Marti, Filippo Martinelli Boneschi, Federco Masserano Zoli, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Lucia Moiola, Sara Montepietra, Margherita MontiBragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile‐Orazio, Agostino Nozzolillo, Marco Onofrj, Doriana Landi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Elisabetta Pedrazzoli, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M. Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Giuditta Ilaria Scarano, Valentina Scarano, Valentina Schillaci, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Emanuela Susani, Giulietta Tabiadon, Francesco Teatini, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Consiglia Trotta, G. Turano, Monica Ulivelli, Valentino Manzo, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Luigi Zuliani,
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim of this study is to compare COVID-19-related outcomes collected in an Italian cohort of patients with MS with the outcomes expected in the age- and sex-matched Italian population.Hospitalization, intensive care unit (ICU) admission, and death after COVID-19 diagnosis of 1,362 patients with MS were compared with the age- and sex-matched Italian population in a retrospective observational case-cohort study with population- ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Wolters Kluwer | Neurology Neuroimmunology & Neuroinflammation
Emanuele Rinninella, Raffaele Borriello, Marco D’Angelo, Tiziano Galasso, Marco Cintoni, Pauline Raoul, Michele Impagnatiello, B.E. Annicchiarico, Antonio Gasbarrini, Maria Cristina Mele,
Hospital malnutrition affects nearly 30% of patients in medical wards and correlates with worse outcomes. An early assessment is necessary to stratify the risk of short-term outcomes and mortality. The predictive role of COntrolling NUTritional status (CONUT) score in this context has not yet been elucidated in Western countries. We aimed to test CONUT at admission as a predictive score of hospital outcomes, in an Internal Medicine and Gastroenterology Department of an Italian Tertiary Care University ...
Tópico(s): Clinical Nutrition and Gastroenterology
2023 - Multidisciplinary Digital Publishing Institute | Nutrients
Vincenzo Guarino, Marco Antonio Alvarez‐Perez, Anna Borriello, Teresa Napolitano, Luigi Ambrosio,
Only recently polymers with intrinsic conductive properties have been studied in relation to their incorporation into bioactive scaffolds for use in tissue engineering. The reason for this interest is that such scaffolds could electrically stimulate cells and thus regulate specific cellular activities, and by this means influence the process of regeneration of those tissues that respond to electrical impulses. In our work, macroporous hydrogels are developed with controlled pore morphology and conductive ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2012 - Wiley | Advanced Healthcare Materials
Stefania Loffredo, Maria Bova, Chiara Suffritti, Francesco Borriello, Andrea Zanichelli, Angelica Petraroli, Gilda Varricchi, Massimo Triggiani, Marco Cicardi, Gianni Marone,
Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare inherited genetic disease characterized by recurrent swelling episodes of the skin, gastrointestinal tract, and upper airways. Angioedema attacks result from increased vascular permeability due to the release of bradykinin from high molecular weight kininogen. Currently, there are no biomarkers predicting the frequency of angioedema attacks. Vascular permeability is modulated by several factors, including vascular endothelial ...
Tópico(s): Autoimmune Bullous Skin Diseases
2016 - Wiley | Allergy
Maria Pia Amato, Benedetta Goretti, Vincenzo Brescia Morra, Paolo Gallo, Mauro Zaffaroni, Marco Onofrj, Eleonora Cocco, Giovanna Borriello, Valentina Zipoli, Maria Trojano,
Tópico(s): Multiple Sclerosis Research Studies
2020 - Springer Science+Business Media | Neurological Sciences
Doriana Landi, Francesca Bovis, Alfonso Grimaldi, Pietro Annovazzi, Antonio Bertolotto, Alessia Bianchi, Giovanna Borriello, Vincenzo Brescia Morra, Sebastiano Bucello, Maria Chiara Buscarinu, Francesca Caleri, Marco Capobianco, Ruggero Capra, Maria Cellerino, Diego Centonze, Raffaella Cerqua, Clara Grazia Chisari, Marinella Clerico, Eleonora Cocco, Gaia Cola, Cinzia Cordioli, Erica Curti, Alessandro d’Ambrosio, Emanuele D’Amico, Giovanna De Luca, Massimiliano Di Filippo, Sonia Di Lemme, Roberta Fantozzi, Diana Ferraro, Elisabetta Ferraro, Antonio Gallo, Claudio Gasperini, Franco Granella, Matilde Inglese, Roberta Lanzillo, Lorena Lorefice, Giacomo Lus, Simona Malucchi, Monica Margoni, Giorgia Mataluni, Massimiliano Mirabella, Lucia Moiola, Carolina Gabri Nicoletti, Viviana Nociti, Francesco Patti, Federica Pinardi, Emilio Portaccio, Carlo Pozzilli, Paolo Ragonese, Sarah Rasia, Giuseppe Salemi, Elisabetta Signoriello, Francesca Vitetta, Rocco Totaro, Maria Pia Sormani, Maria Pia Amato, Girolama Alessandra Marfia,
Objective Assessing the risk of clinical and radiological reactivation during pregnancy and post partum in women with multiple sclerosis (MS) treated with natalizumab (NTZ) throughout pregnancy (LONG_EXP) compared with women interrupting treatment before (NO_EXP) and within >−30 days and ≤90 days from conception (SHORT_EXP), and describing newborns’ outcomes. Methods Maternal clinical and radiological outcomes and obstetric and fetal outcomes were retrospectively collected and compared among groups (NO_EXP, ...
Tópico(s): Polyomavirus and related diseases
2022 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Marco Rubatto, Nadia Sciamarrelli, Silvia Borriello, Valentina Pala, Luca Mastorino, Luca Tonella, Simone Ribero, Pietro Quaglino,
Advanced melanoma and non-melanoma skin cancers (NMSCs) are burdened with a dismal prognosis. To improve the survival of these patients, studies on immunotherapy and target therapies in melanoma and NMSCs are rapidly increasing. BRAF and MEK inhibitors improve clinical outcomes, and anti-PD1 therapy demonstrates better results than chemotherapy or anti-CTLA4 therapy in terms of the survival of patients with advanced melanoma. In recent years, the combination therapy of nivolumab plus ipilimumab has ...
Tópico(s): Immunotherapy and Immune Responses
2023 - Frontiers Media | Frontiers in Medicine
Marco Petrillo, Maddalena Borriello, Gilda Fuoco, Francesco Legge, V. Iannone, Gabriella Ferrandina,
In the last decades, the active research in the field of tumor angiogenesis has led to the development of a class of agents providing an effective inhibition of neo-vessel formation through the blockade of VEGF related pathways. More recently, the identification of other factors involved in tumor angiogenesis, such as platelet-derived growth factor, fibroblast growth factor and Angiopoietins has emphasized the need to develop agents targeting multiple pro-angiogenic pathways. Although contrasting ...
Tópico(s): Cancer Treatment and Pharmacology
2012 - Bentham Science Publishers | Current Pharmaceutical Design
Silverio Perrotta, Natascia Di Iorgi, Fulvio Della Ragione, Saverio Scianguetta, Adriana Borriello, Anna Elsa Maria Allegri, Marcella Ferraro, Claudia Santoro, Flavia Napoli, Annalisa Calcagno, Marta Giaccardi, Marco Cappa, Maria Carolina Salerno, Domenico Cozzolino, Mohamad Maghnie,
Objective Idiopathic early-onset central diabetes insipidus (CDI) might be due to mutations of arginine vasopressin–neurophysin II ( AVP–NPII ( AVP )) or wolframin ( WFS1 ) genes. Design and methods Sequencing of AVP and WFS1 genes was performed in nine children with CDI, aged between 9 and 68 months, and negative family history for polyuria and polydipsia. Results Two patients carried a mutation in the AVP gene: a heterozygous G-to-T transition at nucleotide position 322 of exon 2 (c.322G>T) resulting in ...
Tópico(s): Neuroendocrine regulation and behavior
2015 - Oxford University Press | European Journal of Endocrinology
Luigi Guida, Debora Bencivenga, Marco Annunziata, Francesco Arcadio, Adriana Borriello, Fulvio Della Ragione, A. Formisano, Angelantonio Piccirillo, Luigi Zeni, Nunzio Cennamo,
The evaluation of salivary biomarkers has been proposed as a simple and non-invasive aid to the conventional periodontal diagnosis based on clinical-radiographic parameters. Matrix metalloproteinase-8 (MMP-8), especially in its active form, is considered one of the most reliable biomarkers of periodontitis, and point-of-care tests (POCTs) have been proposed for its clinical monitoring. In this proof-of-concept study, a novel highly sensitive POCT based on a plastic optical fiber (POF) biosensor exploiting ...
Tópico(s): Oral Health Pathology and Treatment
2023 - Elsevier BV | Journal of Dentistry
Francesco Borriello, Valentina Poli, Ellen Shrock, Roberto Spreafico, Xin Liu, Novalia Pishesha, Claire Carpenet, Janet Chou, Marco Di Gioia, Marisa E. McGrath, Carly Dillen, Nora A. Barrett, Lucrezia Lacanfora, Marcella E. Franco, Laura Marongiu, Yoichiro Iwakura, Ferdinando Pucci, Michael Kruppa, Zuchao Ma, Douglas W. Lowman, Harry E. Ensley, Etsuro Nanishi, Yoshine Saito, Timothy R. O’Meara, Hyuk‐Soo Seo, Sirano Dhe‐Paganon, David J. Dowling, Matthew B. Frieman, Stephen J. Elledge, Ofer Levy, Darrell J. Irvine, Hidde L. Ploegh, David L. Williams, Ivan Zanoni,
Summary Activation of the innate immune system via pattern recognition receptors (PRRs) is key to generate lasting adaptive immunity. PRRs detect unique chemical patterns associated with invading microorganisms, but whether and how the physical properties of PRR ligands influence the development of the immune response remains unknown. Through the study of fungal mannans, we show that the physical form of PRR ligands dictates the immune response. Soluble mannans are immunosilent in the periphery but elicit ...
Tópico(s): Bacterial Infections and Vaccines
2022 - Cell Press | Cell
Marco Annunziata, Francesco Arcadio, Adriana Borriello, Debora Bencivenga, Angelantonio Piccirillo, Emanuela Stampone, Luigi Zeni, Nunzio Cennamo, Fulvio Della Ragione, Luigi Guida,
The analysis of salivary biomarkers as expression of periodontal health conditions has been proposed as a useful aid to conventional diagnostic approaches. In this study, we present a point-of-care test (POCT) exploiting a surface plasmon resonance (SPR)-based optical biosensor to detect salivary macrophage inflammatory protein (MIP)-1α, a promising marker of periodontitis. A plastic optical fiber (POF) was suitably modified and functionalized by an antibody self-assembled monolayer against MIP-1α for ...
Tópico(s): Salivary Gland Disorders and Functions
2023 - Cell Press | iScience
Stefania Loffredo, Francesco Borriello, Raffaella Iannone, Anne Lise Ferrara, Maria Rosaria Galdiero, Vincenzo Gigantino, Pasquale Esposito, Gilda Varricchi, Gérard Lambeau, Marco A. Cassatella, Francescopaolo Granata, Gianni Marone,
Secreted phospholipases A2 (sPLA2s) are extracellular enzymes that catalyze the release of free fatty acids and lysophospholipids from membrane phospholipids and also bind to different receptors (e.g., PLA2R1 or integrins). To date, 12 mammalian sPLA2s have been identified, which play a critical role in pathophysiological processes including inflammation and cancer. sPLA2s activate immune cells such as human neutrophils (PMNs) by enzymatic activity- or receptor-mediated mechanisms. In addition, human ...
Tópico(s): Phagocytosis and Immune Regulation
2017 - Frontiers Media | Frontiers in Immunology
Stefania Loffredo, Anne Lise Ferrara, Maria Bova, Francesco Borriello, Chiara Suffritti, Nóra Veszeli, Angelica Petraroli, Maria Rosaria Galdiero, Gilda Varricchi, Francescopaolo Granata, Andrea Zanichelli, Henriette Farkas, Marco Cicardi, Gérard Lambeau, Gianni Marone,
Background: Hereditary angioedema (HAE) caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) is a disabling, potentially fatal condition characterized by recurrent episodes of swelling. We have recently found that patients with C1-INH-HAE have increased plasma levels of vascular endothelial growth factors (VEGFs) and angiopoietins (Angs), which have been associated with vascular permeability in several diseases. Among these and other factors, blood endothelial ...
Tópico(s): Autoimmune Bullous Skin Diseases
2018 - Frontiers Media | Frontiers in Immunology
Nunzio Cennamo, Angelantonio Piccirillo, Debora Bencivenga, Francesco Arcadio, Marco Annunziata, Fulvio Della Ragione, Luigi Guida, Luigi Zeni, Adriana Borriello,
Point-of-Care tests based on biomarkers, useful to monitor acute and chronic inflammations, are required for advances in medicine. In this scope, a key role is played by pro-inflammatory cytokines, of which interleukin 6 (IL-6) is generally thought as one of the most relevant. To use IL-6 in real scenarios, detection in ultra-low concentration ranges is required. In this work, two IL-6 biosensors are obtained by exploiting the combination of the same antibody self-assembled monolayer with two different ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2023 - Elsevier BV | Talanta
Marco Confalonieri, Djillali Annane, Caterina Antonaglia, Mario Santagiuliana, Ediva Myriam Borriello, G. Umberto Meduri,
Community-acquired pneumonia (CAP) has a significant impact on public health in terms of short-term and long-term morbidity and mortality. Irrespective of microbiological etiology, the host's inability to fully downregulate systemic inflammation is the dominant pathogenetic process contributing to acute and long-term morbidity and mortality in CAP. Glucocorticoids are the natural regulators of inflammation, and their production increases during infection. There is consistent evidence that downregulation ...
Tópico(s): Adrenal Hormones and Disorders
2013 - Springer Science+Business Media | Current Infectious Disease Reports
Gian Luca Forni, Valeria Pinto, Marco Musso, Marco Mori, Domenico Girelli, Ilaria Caldarelli, Adriana Borriello, Fulvio Della Ragione,
The combination of marked hypersideremia, hypertransferrinemia, and monoclonal gammopathy of underdetermined significance (MGUS) should alert clinicians to the possible presence of an anti-transferrin immunoglobulin, an uncommon acquired disorder also defined as transferrin-immune complex disease (TICD). The authors have previously described a case of TICD with 100% transferrin saturation and liver iron overload. However, the findings in the few cases so far reported are heterogeneous, and the presence ...
Tópico(s): Erythrocyte Function and Pathophysiology
2013 - Wiley | American Journal of Hematology
Mauro Percudani, Adelaide Panariello, Giacomo Deste, Roberta Bassetti, Giuseppina Borriello, Filippo Cecchetto, Valerio Di Marco, Alessio Falini, Gabriele Nibbio, Irene Calzavara‐Pinton, Domenico Gulizia, Andrea Lassini, Lisa Lavatelli, Deborah Levi, Francesca Lise, F. Malchiodi, Lorenzo Mosca, Piccinini Gianluca, Anna Radice, Giuseppina Romagnoni, Francesca Ruzzi, Stefania Turati, Alberto Zanobio, Antonio Vita,
During the first Covid-19 outbreak, the Niguarda Hospital of Milan featured two Psychiatry wards, one for SARS-CoV-2 positive patient and one for patients requiring hospitalization and negative for SARS-CoV-2. The two groups of patients were compared and were similar in distribution of psychiatric diagnosis, duration of illness and previous hospitalizations. SARS-CoV-2 positive participants had a lower severity of symptoms both at admission and discharge, a lower frequency of psychotic symptoms ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2022 - Elsevier BV | Psychiatry Research