J. Michael O’Donnell, Carlota Sumbilla, Hailun Ma, Iain K. Farrance, Marco Cavagna, Michael G. Klein, Giuseppe Inesi,
Abstract —Collateral effects of exogenous sarcoendoplasmic reticulum Ca 2+ ATPase (SERCA) expression were characterized in neonatal rat and chicken embryo cardiac myocytes, and the conditions required to produce acceleration of Ca 2+ transients with minimal toxicity were established. Cultured myocytes were infected with adenovirus vector carrying the cDNA of wild-type SERCA1, an inactive SERCA1 mutant, or enhanced green fluorescence protein under control of the cytomegalovirus promoter. Controls were ...
Tópico(s): RNA Interference and Gene Delivery
2001 - Lippincott Williams & Wilkins | Circulation Research
Marco Cavagna, J. Michael O’Donnell, Carlota Sumbilla, Giuseppe Inesi, Michael G. Klein,
1 Sarco-endoplasmic reticulum Ca2+-ATPase from fast skeletal (SERCA1) or cardiac muscle (SERCA2a) was expressed in embryonic chicken and neonatal rat cardiac myocytes by adenovirus vectors, with c-myc tags on both constructs to compare expression and distinguish exogenous from endogenous SERCA2a in myocytes. 2 Expression of the two isoforms was similar (approximately 3-fold higher than endogenous SERCA). However, SERCA1 activity was 2-fold greater than SERCA2a activity, due to intrinsic differences ...
Tópico(s): Viral Infections and Immunology Research
2000 - Wiley | The Journal of Physiology
Carlota Sumbilla, Marco Cavagna, Lilin Zhong, Hailun Ma, David Y. Lewis, Iain K. Farrance, Giuseppe Inesi,
Cultured COS-1 cells, as well as chicken embryonic and neonatal rat cardiac myocytes, were infected with recombinant adenovirus vectors to define limiting factors in the expression and Ca 2+ transport function of recombinant sarcoplasmic-endoplasmic reticulum Ca 2+ (SERCA) isoforms. Titration experiments showed that all COS-1 cells and myocytes in culture could be infected by an adenovirus titer of 10 plaque-forming units (pfu) per seeded cell. Raising the adenovirus titer further yielded higher protein ...
Tópico(s): Ion channel regulation and function
1999 - American Physical Society | AJP Heart and Circulatory Physiology
Christopher Strock, Marco Cavagna, Wendy E. Peiffer, Carlota Sumbilla, David E. Lewis, Giuseppe Inesi,
Single mutations of specific amino acids within the membrane-bound region of the sarco-endoplasmic reticulum Ca2+ (SERCA)-1 ATPase interfere with Ca2+inhibition of ATPase phosphorylation by Pi (1Clarke D.M. Loo T.W. Inesi G. MacLennan D.H. Nature. 1989; 339: 476-478Crossref PubMed Scopus (505) Google Scholar), suggesting that these residues may be involved in complexation of two Ca2+ that are known to bind to the enzyme. However, direct measurements of Ca2+ binding in the absence of ATP have been limited ...
Tópico(s): Erythrocyte Function and Pathophysiology
1998 - Elsevier BV | Journal of Biological Chemistry
Konstantinos Triantafyllias, M. De Blasi, Freya Lütgendorf, Lorenzo Cavagna, Marco Stortz, Julia Weinmann‐Menke, Stavros Konstantinides, Peter R. Galle, Andreas Schwarting,
... Blasi : None declared, Freya Lütgendorf: None declared, Lorenzo Cavagna: None declared, Marco Stortz: None declared, Julia Weinmann-Menke : None declared, ...
Tópico(s): Cardiovascular Disease and Adiposity
2019 - BMJ | Annals of the Rheumatic Diseases
Giulia Dei, Paola Rebora, Martina Catalano, Marco Sebastiani, Paola Faverio, Maria Rosa Pozzi, Andreina Manfredi, Paolo Cameli, Francesco Salton, Carlo Salvarani, Lorenzo Cavagna, Marco Confalonieri, Elena Bargagli, Fabrizio Luppi, Alberto Pesci,
Antisynthetase syndrome (ASSD) is a rare autoimmune disease characterized by serologic positivity for antisynthetase antibodies. Anti-Jo1 is the most frequent, followed by anti PL-7, anti PL-12, anti EJ, and anti OJ antibodies. The lung is the most frequently affected organ, usually manifesting with an interstitial lung disease (ILD), which is considered the main determinant of prognosis. Some evidences suggest that non-anti-Jo-1 antibodies may be associated with more severe lung involvement and possibly ...
Tópico(s): Systemic Sclerosis and Related Diseases
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Piero Angeli, Franco Cantalamessa, Roberto Cavagna, Paola Conti, Marco De Amici, Carlo De Micheli, Anna Gamba, Gabriella Marucci,
The four homochiral 4-deoxy-4,4-difluoromuscarine stereoisomers (difluoromuscarines) were prepared in very high enantiomeric excess. A convenient sequence based on the use of natural as well as "unnatural" ethyl lactate allowed the synthesis of target compounds, whose absolute configuration is dictated by that of the starting synthon. Quaternary ammonium salts (+)-5, (−)-5, (−)-6, and (+)-6 were tested in vitro on guinea pig tissues, and their muscarinic potency was evaluated at M2 (heart) and M3 (ileum and bladder) ...
Tópico(s): Fluorine in Organic Chemistry
1997 - American Chemical Society | Journal of Medicinal Chemistry
Marco Fogante, Enrico Cavagna, Giovanni Rinaldi,
To evaluate the radiological sequelae of coronavirus disease (COVID-19) in a mid-term follow-up and investigate their relationship with clinical-radiological findings.This prospective study included COVID-19 patients who underwent a CXR three months after discharge. The relationship between CXR score at three months after discharge and clinical findings and previous CXR scores, at admission and before the discharge, were evaluated. Then, based on mid-term follow-up CXR score, patients were divided ...
Tópico(s): Pericarditis and Cardiac Tamponade
2021 - Elsevier BV | Radiography
Veronica Codullo, Emanuela Cova, Laura Pandolfi, S. Breda, Monica Morosini, Vanessa Frangipane, Manuela Malatesta, Laura Calderan, Maddalena Cagnone, Chiara Pacini, Lorenzo Cavagna, Helios Recalde, Jörg H. W. Distler, Marco Giustra, Davide Prosperi, Miriam Colombo, Federica Meloni, Carlomaurizio Montecucco,
Interstitial lung involvement in Systemic Sclerosis (SSc-ILD) is a complication with high morbidity and mortality. Specifically, engineered gold nanoparticles (GNPs) are proposed as targeted delivery system increasing efficacy of drugs with antifibrotic effect, such as tyrosine kinases. We aimed to test in vitro and in vivo the activity of targeted Imatinib (Im)-loaded GNP on SSc-ILD patients derived cells and in experimental model of lung fibrosis. GNPs functionalized with anti-CD44 and loaded with ...
Tópico(s): Eosinophilic Disorders and Syndromes
2019 - Elsevier BV | Journal of Controlled Release
Lorenzo Cavagna, Miguel Á. González‐Gay, Yannick Allanore, Marco Matucci‐Cerinic,
IPAF classification criteria include several autoimmune conditions with different evolution. The progression into established CTD is common and a continuous up-to-date process of classification criteria of both IPAF and CTD is mandatory. http://ow.ly/pXNW30knUzl
Tópico(s): Inflammatory Myopathies and Dermatomyositis
2018 - European Respiratory Society | European Respiratory Review
Pietro Canzi, Federico Aprile, Marco Manfrin, Irene Avato, Marianna Magnetto, Domenico Minervini, Lorenzo Cavagna, Marco Benazzo,
Polyarteritis nodosa (PAN) is a systemic vasculitis affecting the small- and medium-sized arteries that may present with hearing impairment. In rare cases, PAN may be associated with progressive labyrinthitis ossificans (LO), an otologic emergency requiring early cochlear implantation (CI) to restore hearing before the complete, irreversible cochlear ossification. We report the first case in the literature of a patient affected by PAN with bilateral sudden sensorineural hearing loss and rapid LO who ...
Tópico(s): Inflammasome and immune disorders
2018 - AVES | The Journal of International Advanced Otology
Francesco Dela Pierre, Pierangelo Clari, Elisa Bernardi, Marcello Natalicchio, Emanuele Costa, Simona Cavagna, Francesca Lozar, Stefano Lugli, Vinicio Manzi, Marco Roveri, Donata Violanti,
The seven Messinian microbial carbonate-rich layers cropping out in the Pollenzo section (Tertiary Piedmont Basin, NW Italy) are interbedded with a precession-related cyclic succession composed of euxinic shale/marl couplets and straddle the onset of the Messinian salinity crisis (MSC). A sharp change of sedimentological, compositional and geochemical characteristics was observed from the onset of the MSC onward, suggesting strong differences in the mechanisms responsible for carbonate precipitation. ...
Tópico(s): Paleontology and Stratigraphy of Fossils
2012 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology
Gianluca Sambataro, Domenico Sambataro, Lucia Spicuzza, Federica Meloni, Giorgio Lorini, Lorenzo Malatino, Michele Colaci, Gian Domenico Sebastiani, Anna Iuliano, Claudia Canofari, Fabrizio Luppi, Giovanni Franco, Umberto Zanini, Andreina Manfredi, Filippo Gozzi, Marco Sebastiani, Stefano Palmucci, Lorenzo Cavagna, Carlo Vancheri,
ObjectiveTo evaluate the rate of progression towards specific autoimmune diseases (SADs) of a prospective, multi-centre cohort of patients classifiable as interstitial pneumonia with autoimmune features (IPAF). Methods IPAF patients were enrolled based on specific research criteria, and jointly followed by rheumatologists and pulmonologists for at least one year with clinical check-ups, serological exams including autoimmunity, capillaroscopyand high-resolution computed tomography (HRCT).Diagnostic ...
Tópico(s): Inflammatory Myopathies and Dermatomyositis
2022 - Springer Vienna | Clinical and Experimental Rheumatology
Marco Fornaro, Francesco Girolamo, Lorenzo Cavagna, Franco Franceschini, Margherita Giannini, Angela Amati, Annamaria Lia, Marilina Tampoia, Dario D’Abbicco, Lorenzo Maggi, Micaela Fredi, Giovanni Zanframundo, Liala Moschetti, L. Coladonato, Florenzo Iannone,
The aim of our study was to investigate clinical and histopathological findings in adult DM patients positive for anti-Mi2 (anti-Mi2+) antibodies compared with DM patients negative for anti-Mi2 (anti-Mi2-).Clinical data of adult DM patients, who fulfilled EULAR/ACR 2017 classification criteria, were gathered from electronic medical records of three tertiary Rheumatology Units. Histopathological study was carried out on 12 anti-Mi2+ and 14 anti-Mi2- muscle biopsies performed for diagnostic purpose. ...
Tópico(s): Skin Diseases and Diabetes
2020 - Oxford University Press | Lara D. Veeken
Pasquale Capaccio, Pietro Canzi, Sara Torretta, Verónica Rossi, Marco Benazzo, Anna Bossi, Claudio Vitali, Lorenzo Cavagna, Lorenzo Pignataro,
Abstract Objectives To evaluate the effectiveness of interventional sialendoscopy alone or combined with outpatient intraductal steroid irrigations in patients with sialadenitis due to Sjögren's syndrome ( SS ). Design A pilot therapeutic study. Setting ENT Clinics, Universities of Milan and Pavia. Study Population We included 22 patients with SS of whom 12 underwent interventional sialendoscopy followed by intraductal steroid irrigations (group A), and 10 interventional sialendoscopy alone (group B). ...
Tópico(s): Oral Health Pathology and Treatment
2017 - Wiley | Clinical Otolaryngology
Renzo Mignani, Cristiana Corsi, Mariangela De Marco, Enrico G. Caiani, Gioele Santucci, Enrico Cavagna, Stefano Severi, L Cagnoli,
Total renal volume (TRV) is an important index to evaluate the progression of autosomal-dominant polycystic kidney disease (ADPKD). TRV has been assessed by manually tracing renal contours from CT or MR scans, often employing contrast medium (CM). We developed a fast and nearly automated technique based on the analysis of MR images acquired without CM injection for TRV quantification.30 ADPKD patients underwent MRI. After the selection of one point inside each kidney for the entire volume, the automatic ...
Tópico(s): Pediatric Urology and Nephrology Studies
2011 - Karger Publishers | American Journal of Nephrology
Francesco Dela Pierre, Elisa Bernardi, Simona Cavagna, Pierangelo Clari, Rocco Gennari, Andrea Irace, Francesca Lozar, Stefano Lugli, Vinicio Manzi, Marcello Natalicchio, Marco Roveri, Donata Violanti,
The Alba succession (Tertiary Piedmont Basin, NW Italy) preserves the northernmost record of the Messinian salinity crisis (MSC) and was deposited on the southern margin of a wide wedge-top basin, related to the involvement of the Piedmont Basin in the Apennine compressional tectonics. Pre-MSC sediments consist of a cyclic succession of marine euxinic shales and calcareous marls, deposited under the influence of precession-modulated climate changes, and document the progressive restriction of the ...
Tópico(s): Hydrocarbon exploration and reservoir analysis
2011 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology
Micaela Fredi, Ilaria Cavazzana, Angela Ceribelli, Lorenzo Cavagna, Simone Barsotti, Elena Bartoloni, Maurizio Benucci, Ludovico De Stefano, Andrea Doria, Giacomo Emmi, Martina Fabris, Marco Fornaro, Federica Furini, Maria Grazia Giudizi, Marcello Govoni, Anna Ghirardello, Luca Iaccarino, Florenzo Iannone, María Infantino, Natasa Isailovic, Maria Grazia Lazzaroni, Mariangela Manfredi, Alessandro Mathieu, Emiliano Marasco, Paola Migliorini, Carlomaurizio Montecucco, Boaz Palterer, Paola Parronchi, Matteo Piga, Federico Pratesi, Valeria Riccieri, Carlo Selmi, Marilina Tampoia, Alessandra Tripoli, Giovanni Zanframundo, Antonella Radice, Roberto Gerli, Franco Franceschini,
Abstract The identification of anti-NXP2 antibodies is considered a serological marker of dermatomyositis (DM), with calcinosis, severe myositis and, in some reports, with cancer. Historically, these associations with anti-NXP2 antibodies have been detected by immunoprecipitation (IP), but in the last few years commercial immunoblotting assays have been released. The aim of this collaborative project was to analyse the clinical features associated to anti-NXP2 antibodies, both with commercial line ...
Tópico(s): Dermatological and Skeletal Disorders
2022 - Springer Nature | Clinical Reviews in Allergy & Immunology
Marco Sebastiani, Konstantinos Triantafyllias, Andreina Manfredi, Miguel Á. González‐Gay, Natalia Palmou‐Fontana, Giulia Cassone, Ulrich Drott, Christiane Delbrück, Jorge Rojas‐Serrano, Chiara Bertolazzi, Laura Nuño, Margherita Giannini, Florenzo Iannone, Esther Vicente, Santos Castañeda, Albert Selva-O’Callaghan, Ernesto Trallero‐Araguás, Giacomo Emmi, Annamaria Iuliano, Jutta Bauhammer, N. Miehle, Simone Parisi, Lorenzo Cavagna, Veronica Codullo, Carlomaurizio Montecucco, Francisco Javier López-Longo, Julia Martínez‐Barrio, Juan Carlos Nieto‐González, Silvia Vichi, Marco Confalonieri, Paola Tomietto, Raoul Bergner, Alberto Sulli, Francesco Bonella, Federica Furini, Carlo Alberto Scirè, Alessandra Bortoluzzi, Christof Specker, Simone Barsotti, R Neri, Marta Mosca, Marzia Caproni, Julia Weinmann‐Menke, Andreas Schwarting, Vanessa Smith, Maurizio Cutolo,
Objective. To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease. Methods. We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non–anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, ...
Tópico(s): Skin Diseases and Diabetes
2018 - The Journal of Rheumatology Publishing Company Limited | The Journal of Rheumatology
Quentin Wehrung, Linda Pastero, Davide Bernasconi, Andrea Cotellucci, Marco Bruno, Simona Cavagna, Enrico Destefanis, Caterina Caviglia, Alessandrο Pavese,
The impact of operational parameters on the CO2 absorption rate (η(t)) during Ca(OH)2 aqueous carbonation has been investigated, including the reagent concentration, CO2 volumetric flow rate, temperature, Na- and K-salt impurity concentration, ionic strength, and mixing system. The carbonation mechanisms were numerically investigated with the modeling tool Phreeqc. Positive correlations were predicted and confirmed between η(t) and Ca(OH)2 initial concentrations, reduced volumetric flow rate, elevated ...
Tópico(s): Carbon Dioxide Capture Technologies
2024 - American Chemical Society | Energy & Fuels
Produção Nacional
Revisado por pares
Nicola Dalbeth, H. Ralph Schumacher, Jaap Fransen, Tuhina Neogi, Tim Jansen, Melanie Brown, Worawit Louthrenoo, Janitzia Vázquez‐Mellado, М. С. Елисеев, Géraldine McCarthy, Lisa K. Stamp, Fernando Perez‐Ruiz, Francisca Sivera, Hang‐Korng Ea, Martijn Gerritsen, Carlo Alberto Scirè, Lorenzo Cavagna, Ching-Tsai Lin, Yin‐Yi Chou, Anne‐Kathrin Tausche, Geraldo da Rocha Castelar Pinheiro, M. Janssen, Jiunn‐Horng Chen, Marco A. Cimmino, Till Uhlig, William J. Taylor,
Objective To identify the best‐performing survey definition of gout from items commonly available in epidemiologic studies. Methods Survey definitions of gout were identified from 34 epidemiologic studies contributing to the Global Urate Genetics Consortium (GUGC) genome‐wide association study. Data from the Study for Updated Gout Classification Criteria (SUGAR) were randomly divided into development and test data sets. A data‐driven case definition was formed using logistic regression in the development ...
Tópico(s): Case Reports on Hematomas
2016 - Wiley | Arthritis Care & Research
Veronica Codullo, Ilaria Cavazzana, Claudia Bonino, Claudia Alpini, Lorenzo Cavagna, Franco Cozzi, Nicoletta Del Papa, Franco Franceschini, Serena Guiducci, Gabriella Morozzi, Amelia Ruffatti, Clodoveo Ferri, Roberto Giacomelli, Marco Matucci‐Cerinic, Gabriele Valentini, Carlomaurizio Montecucco,
Objective. To analyze clinical and serological characteristics of subjects with scleroderma renal crisis (SRC) in Italian patients with systemic sclerosis (SSc). Methods. A retrospective analysis of medical records from 9 Italian rheumatologic referral centers was carried out. All patients with SRC and an available serum sample at the time of crisis were included. Antinuclear antibodies (ANA) by indirect immunofluorescence, anti-topoisomerase (topo) I by enzyme-linked assay (ELISA), anti-RNA polymerases ( ...
Tópico(s): Dermatologic Treatments and Research
2009 - The Journal of Rheumatology Publishing Company Limited | The Journal of Rheumatology
Luca Cavagna, Alessandro Fumagalli, Pierangelo Masarati, Marco Morandini, Paolo Mantegazza,
Wind-turbines represent an important means to extract energy from the environment in a 'green' manner. The concept of extracting energy from the wind dates back thousands of years, including not only power generation (e.g. mills, water pumps) but also direct locomotion (e.g. sailing). Modern wind-energy technology relies on efficient aerodynamic design and durable mechanical systems.
Tópico(s): Vibration and Dynamic Analysis
2010 - Springer Nature (Netherlands) | Computational methods in applied sciences
Produção Nacional
Revisado por pares
R Naveen, Ioannis Parodis, Mrudula Joshi, Parikshit Sen, Julius Lindblom, Vishwesh Agarwal, James B Lilleker, Ai Lyn Tan, Arvind Nune, Samuel Katsuyuki Shinjo, Babur Salim, Nelly Ziadé, Tsvetelina Velikova, Abraham Edgar Gracia‐Ramos, Miguel Ángel Saavedra, Jessica Day, Ashima Makol, Oliver Distler, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta, Elena Nikiphorou, Bhupen Barman, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C Pandya, Rakesh Kumar Pilania, Aman Sharma, Matthew Antony Manoj, Vikas Gupta, Chengappa Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arun Kumar R Pandey, Kunal Chandwar, Sinan Kardeş, Döndü Üsküdar Cansu, Min‐Chul Kim, Ashima Makol, Tulika Chatterjee, John D Pauling, Chris Wincup, Lorenzo Cavagna, Nicoletta Del Papa, Gianluca Sambataro, Fabiola Atzeni, Marcello Govoni, Simone Parisi, Elena Bartoloni, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Dr Marcin Milchert, Lisa S Traboco, Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas‐Serrano, Ignacio Garcı́a-De La Torre, Jesús Loarce-Martos, Sergio Prieto‐González, Albert Gil‐Vila, Raquel González, Masataka Kuwana, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Johannes Knitza, Stylianos Tomaras, Margarita Aleksandrovna Gromova, Or Aharonov, Tamer A. Gheita, Ihsane Hmamouchi, Leonardo Santos Hoff, Margherita Giannini, F. Maurier, J. Campagne, Alain Meyer, Melinda Nagy‐Vincze, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Marie Hudson, Océane Landon‐Cardinal, Syahrul Sazliyana Shaharir, Wilmer Gerardo Rojas Zuleta, José António Pereira Silva, João Eurico Fonseca, Olena Zimba,
Abstract Objectives The COVID-19 vaccination in autoimmune diseases (COVAD) study aimed to assess short-term COVID-19 vaccination-related adverse events (AEs) in RA patients. Methods An online self-reported questionnaire (March–December 2021) was used to capture data related to COVID-19 vaccination-related AEs in RA, other autoimmune rheumatic diseases (AIRDs) (excluding RA and inflammatory myositis), non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs). Descriptive and multivariable regression ...
Tópico(s): Immunotherapy and Immune Responses
2022 - Oxford University Press | Lara D. Veeken
Gian Luca Erre, Marco Sebastiani, Maria Antonietta Fenu, Angelo Zinellu, Alberto Floris, Lorenzo Cavagna, Elisabetta Renzoni, Andreina Manfredi, Giuseppe Passiu, Richard Woodman, Arduino A. Mangoni,
Background: There is a paucity of head-to-head comparisons of the efficacy and harms of pharmacological treatments for systemic sclerosis-related interstitial lung disease (SSc-ILD). Methods: We conducted a network meta-analysis (NMA) in order to compare the effects of different treatments with the placebo on change in forced vital capacity (FVC), change in diffusion lung capacity for CO (DLCO), serious adverse events (SAEs), discontinuation for adverse events and mortality in SSc-ILD. Standardized mean ...
Tópico(s): Inflammatory Myopathies and Dermatomyositis
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Produção Nacional
Revisado por pares
William J. Taylor, Jaap Fransen, Tim Jansen, Nicola Dalbeth, H. Ralph Schumacher, Melanie Brown, Worawit Louthrenoo, Janitzia Vázquez‐Mellado, М. С. Елисеев, Géraldine McCarthy, Lisa K. Stamp, Fernando Perez‐Ruiz, Francisca Sivera, Hang‐Korng Ea, Martijn Gerritsen, Carlo Alberto Scirè, Lorenzo Cavagna, Ching-Tsai Lin, Yin‐Yi Chou, A.-K. Tausche, Ana Beatriz Vargas‐Santos, M. Janssen, Jiunn‐Horng Chen, Ole Slot, Marco A. Cimmino, Till Uhlig, Tuhina Neogi,
Objective To determine which clinical, laboratory, and imaging features most accurately distinguished gout from non‐gout. Methods We performed a cross‐sectional study of consecutive rheumatology clinic patients with ≥1 swollen joint or subcutaneous tophus. Gout was defined by synovial fluid or tophus aspirate microscopy by certified examiners in all patients. The sample was randomly divided into a model development (two‐thirds) and test sample (one‐third). Univariate and multivariate association between ...
Tópico(s): Alcohol Consumption and Health Effects
2015 - Wiley | Arthritis Care & Research
William J. Taylor, Jaap Fransen, Nicola Dalbeth, Tuhina Neogi, H Ralph Schumacher, Melanie Brown, Worawit Louthrenoo, Janitzia Vazquez-Mellado, М. С. Елисеев, Géraldine McCarthy, Lisa K Stamp, Fernando Perez‐Ruiz, Francisca Sivera, Hang‐Korng Ea, Martijn Gerritsen, Carlo A Scire, Lorenzo Cavagna, Chingtsai Lin, Yin-Yi Chou, Anne-Kathrin Tausche, Geraldo da Rocha Castelar Pinheiro, M. Janssen, Jiunn-Horng Chen, Ole Slot, Marco Cimmino, Till Uhlig, Tim L Jansen,
Objective. To determine the frequency of adverse events of diagnostic arthrocentesis in patients with possible gout. Methods. Consecutive patients underwent arthrocentesis and were evaluated at 6 weeks to determine adverse events. The 95% CI were obtained by bootstrapping. Results. Arthrocentesis was performed in 910 patients, and 887 (97.5%) were evaluated for adverse events. Any adverse event was observed in 12 participants (1.4%, 95% CI 0.6–2.1). There was 1 case (0.1%, 95% CI 0–0.34) of septic ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2015 - The Journal of Rheumatology Publishing Company Limited | The Journal of Rheumatology
R Naveen, Elena Nikiphorou, Mrudula Joshi, Parikshit Sen, Julius Lindblom, Vishwesh Agarwal, James B Lilleker, Ai Lyn Tan, Babur Salim, Nelly Ziadé, Tsvetelina Velikova, Abraham Edgar Gracia‐Ramos, Masataka Kuwana, Jessica Day, Ashima Makol, Oliver Distler, Hector Chinoy, Lisa S Traboco, Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas‐Serrano, Ignacio Garcı́a-De La Torre, Bhupen Barman, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C Pandya, Rakesh Kumar Pilania, Aman Sharma, Manesh Manoj, Vikas Gupta, Chengappa Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arun Kumar R Pandey, Kunal Chandwar, Sinan Kardeş, Döndü Üsküdar Cansu, Minchul Kim, Ashima Makol, Tulika Chatterjee, John D Pauling, Chris Wincup, Lorenzo Cavagna, Nicoletta Del Papa, Gianluca Sambataro, Fabiola Atzeni, Marcello Govoni, Simone Parisi, Elena Bartoloni, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Marcin Milchert, Lisa S Traboco, Suryo Anggoro Kusumo Wibowo, Erick Adrian Zamora Tehozol, Jorge Rojas‐Serrano, Ignacio Garcı́a-De La Torre, Jesús Loarce-Martos, Sergio Prieto‐González, Albert Gil‐Vila, Raquel González, Masataka Kuwana, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Johannes Knitza, Stylianos Tomaras, Margarita Aleksandrovna Gromova, Or Aharonov, Tamer A. Gheita, Ihsane Hmamouchi, Leonardo Santos Hoff, Margherita Giannini, F. Maurier, J. Campagne, Alain Meyer, Melinda Nagy‐Vincze, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Marie Hudson, Océane Landon‐Cardinal, Syahrul Sazliyana Shaharir, Wilmer Gerardo Rojas Zuleta, José António Pereira Silva, João Eurico Fonseca, Olena Zimba, Rohit Aggarwal, Latika Gupta, Vikas Agarwal, Ioannis Parodis,
Abstract Objective To determine COVID-19 vaccine-related adverse events (AEs) in the seven-day post-vaccination period in patients with SLE vs autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HC). Methods Data were captured through the COVID-19 Vaccination in Autoimmune Diseases (COVAD) questionnaire (March–December 2021). Multivariable regression models accounted for age, gender, ethnicity, vaccine type and background treatment. Results Among 9462 ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2022 - Oxford University Press | Lara D. Veeken
Produção Nacional
Revisado por pares
William J. Taylor, Jaap Fransen, Nicola Dalbeth, Tuhina Neogi, H. Ralph Schumacher, Melanie Brown, Worawit Louthrenoo, Janitzia Vázquez‐Mellado, М. С. Елисеев, Géraldine McCarthy, Lisa K. Stamp, Fernando Perez‐Ruiz, Francisca Sivera, Hang‐Korng Ea, Martijn Gerritsen, Carlo Alberto Scirè, Lorenzo Cavagna, Ching-Tsai Lin, Yin-Yi Chou, Anne-Kathrin Tausche, Geraldo da Rocha Castelar Pinheiro, M. Janssen, Jiunn-Horng Chen, Ole Slot, Marco A. Cimmino, Till Uhlig, Tim Jansen,
To compare the sensitivity and specificity of different classification criteria for gout in early and established disease.This was a cross-sectional study of consecutive rheumatology clinic patients with joint swelling in which gout was defined by presence or absence of monosodium urate crystals as observed by a certified examiner at presentation. Early disease was defined as patient-reported onset of symptoms of 2 years or less.Data from 983 patients were collected and gout was present in 509 (52%). ...
Tópico(s): Urticaria and Related Conditions
2014 - BMJ | Annals of the Rheumatic Diseases
Chiara Tani, Dina Zucchi, Isabell Haase, Maria Gerosa, Maddalena Larosa, Lorenzo Cavagna, Alessandra Bortoluzzi, Francesca Crisafulli, Johanna Mücke, Francesca Anna Letizia Strigini, Laura Baglietto, Marco Fornili, Francesca Monacci, Elena Elefante, Roberta Erra, Elisa Bellis, Melissa Padovan, Laura Andréoli, Lavinia Agra Coletto, Giovanni Zanframundo, Marcello Govoni, Luca Iaccarino, Anǵela Tincani, Andrea Doria, Rebecca Fischer‐Betz, Marta Mosca,
Objective It is still a matter of debate whether low-dose acetylsalicylic acid (LDASA) should be prescribed to all patients with SLE during pregnancy. This study aimed at investigating the impact of LDASA on pregnancy outcomes in patients with SLE without history of renal involvement and without antiphospholipid antibodies (aPL). Methods This is a retrospective analysis of prospectively monitored pregnancies at seven rheumatology centres. Previous/current renal involvement and aPL positivity were ...
Tópico(s): Pregnancy and preeclampsia studies
2022 - BMJ | Lupus Science & Medicine