Giovenzio Genestreti, Francesco Grossi, Carlo Genova, Marco Angelo Burgio, Alberto Bongiovanni, Giampaolo Gavelli, Marco Bartolotti, Monica Di Battista, Giovanna Cavallo, Alba A. Brandes,
Non-small-cell lung cancer (NSCLC) treatment has led to improved efficacy and compliance due to individual tailoring of the therapeutic options and the use of strategies based on both clinical characteristics and histological and biological features of the disease. In nonsquamous NSCLC, novel agents, such as pemetrexed and bevacizumab, have improved survival in the first-line setting. Maintenance therapy with pemetrexed and erlotinib resulted in improved progression-free survival compared with second- ...
Tópico(s): Colorectal Cancer Treatments and Studies
2014 - Future Medicine | Future Oncology
Q. L. Niu, He Shuchang, Wu Sheng, Mario Di Gioacchino, N. Verna, Anna Rita Volpe, Luca Di Giampaolo, Marco Carmignani, P Boscolo,
Objective of this study was to assess effects of manganese (Mn) exposure on 56 workers employed in a Mn welding workshop of a machine building factory in Taiyuan (Shanxi Province, P.R. China) for a mean period of 16.1 years. The mean air Mn level in the workshop was 138.4 microg/m3. Neurobehavioral Core Test Battery (NCTB), including the Profile fo Mood States, (POMS), was performed. Blood pressure (BP) increase following immediate stand-up (BP-IS), serum prolactin (PRL) and plasma renin activity (PRA) ...
Tópico(s): Mercury impact and mitigation studies
2004 - SAGE Publishing | International Journal of Immunopathology and Pharmacology
Paolo Muratori, Marco Carbone, Giorgia Stangos, Lisa Perini, Claudine Lalanne, Vincenzo Ronca, Nora Cazzagon, Giampaolo Bianchi, Marco Lenzi, Annarosa Floreani, Pietro Invernizzi, Luigi Muratori,
Autoimmune Hepatitis (AIH) can present under clinical profile as acute hepatitis of unexplained cause. We analyzed clinical, therapeutical and prognostic implications of AIH presenting as acute hepatitis in a cohort of patients admitted to 3 referral Centres in Italy. AIH onset was considered acute when transaminases were higher than 10 times the normal limit and/or bilirubin higher than 5 mg/ml (irrespectively from the histology, available only in 62% of cases). Among 479 patients diagnosed as AIH, ...
Tópico(s): Hepatitis B Virus Studies
2018 - Elsevier BV | Digestive and Liver Disease
Giovanni De Carne, Giampaolo Buticchi, Marco Liserre, Constantine Vournas,
In the last years, the energy production share of power electronics-based generators has kept increasing with respect to the synchronous generation. These power electronics-resources do not offer rotational inertia, resulting in a decrease of the total system inertia and thus in larger frequency deviations during disturbances. Among several corrective solutions studied in the literature, controlling the load consumption is a promising one. Fast in power response and widely distributed in the grid, ...
Tópico(s): Power System Optimization and Stability
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Smart Grid
Laura Bonzano, Ludovico Pedullà, Matteo Pardini, Andrea Tacchino, Paola Zaratin, Mario Alberto Battaglia, Giampaolo Brichetto, Marco Bove,
Cognitive impairment and related abnormal brain activity are common in people with multiple sclerosis (PwMS). Adaptive training based on working memory (WM) has been shown to ameliorate cognitive symptoms, although the effects at a neural level are unclear. The aim of this study was to expand the existing research on the effects of an adaptive WM rehabilitative intervention on brain functional activity in PwMS. A sample of eighteen PwMS performed an 8-week home-based cognitive rehabilitation treatment ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2018 - Springer Science+Business Media | Brain Imaging and Behavior
Domenico De Berardis, Gabriella Rapini, Luigi Olivieri, Domenico Di Nicola, Carmine Tomasetti, Alessandro Valchera, Michele Fornaro, Fabio Di Fabio, Giampaolo Perna, Marco Di Nicola, Gianluca Serafini, Alessandro Carano, Maurizio Pompili, Federica Vellante, Laura Orsolini, Giovanni Martinotti, Massimo Di Giannantonio,
Clozapine, a dibenzodiazepine developed in 1961, is a multireceptorial atypical antipsychotic approved for the treatment of resistant schizophrenia. Since its introduction, it has remained the drug of choice in treatment-resistant schizophrenia, despite a wide range of adverse effects, as it is a very effective drug in everyday clinical practice. However, clozapine is not considered as a top-of-the-line treatment because it may often be difficult for some patients to tolerate as some adverse effects ...
Tópico(s): Electroconvulsive Therapy Studies
2018 - SAGE Publishing | Therapeutic Advances in Drug Safety
Pramod Kumar Prasobhu, Vivek Raveendran, Giampaolo Buticchi, Marco Liserre,
The new packaging technologies used for gallium nitride (GaN) devices avoid wire bonds and leads in order to completely utilize their switching performance. This also means that thermomechanical fatigue that used to exist within the device may no longer be a reliability problem. And one of the main bottlenecks for reliability will be the solder joints between the device and the printed circuit board (PCB). To limit the thermal cycling induced failures in these points, an active thermal control scheme ...
Tópico(s): Semiconductor materials and devices
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industry Applications
Domenico De Berardis, Michele Fornaro, Alessandro Valchera, Marilde Cavuto, Giampaolo Perna, Marco Di Nicola, Gianluca Serafini, Alessandro Carano, Maurizio Pompili, Federica Vellante, Laura Orsolini, Annastasia Fiengo, Antonio Ventriglio, Yong‐Ku Kim, Giovanni Martinotti, Massimo Di Giannantonio, Carmine Tomasetti,
Despite the continuous advancement in neurosciences as well as in the knowledge of human behaviors pathophysiology, currently suicide represents a puzzling challenge. The World Health Organization (WHO) has established that one million people die by suicide every year, with the impressive daily rate of a suicide every 40 s. The weightiest concern about suicidal behavior is how difficult it is for healthcare professionals to predict. However, recent evidence in genomic studies has pointed out the ...
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Levy F. Costa, Giampaolo Buticchi, Marco Liserre,
The modular smart transformer (ST) is composed by several basic converters rated for lower voltage and power. In this paper, the quadruple active bridge (QAB) is used as the basic block for the modular ST. In this application, the efficiency and cost are the most important design parameters. Therefore, the paper focus on the design of the converter, with the aim to optimize its efficiency, taking the cost into consideration. To do so, the losses of all components are carefully modeled and a computer- ...
Tópico(s): Multilevel Inverters and Converters
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Youngjong Ko, Markus Andresen, Giampaolo Buticchi, Marco Liserre,
With the increasing renewable energy injected into the electrical distribution grid, the reliability of the power converter is gaining importance for the power system. In order to address the wear-out caused failure mechanisms of power semiconductors and thereby increasing the reliability, this paper aims at balancing the thermal stress caused during operation between different power converters in a wind park. An active thermal control strategy based on the discontinuous pulsewidth modulation is ...
Tópico(s): Advanced DC-DC Converters
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Vito Giuseppe Monopoli, Abraham Marquez, José I. Leon, Youngjong Ko, Giampaolo Buticchi, Marco Liserre,
Among multilevel converter topologies, the cascaded H-bridge (CHB) converter is one suitable solution for multiple applications, such as flexible ac transmission systems and motor drives. CHB presents a natural high modularity because it is formed by the serial connection of H-bridges. This paper deals with a CHB where the cells do not have the same aging because the maintenance during the years of operation forces to replace some damaged cells of the converter with new or repaired ones. A method ...
Tópico(s): Silicon Carbide Semiconductor Technologies
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Zhixiang Zou, Giampaolo Buticchi, Marco Liserre,
The interaction of the smart transformer (ST) with the grid-converter-based distributed energy resources (DERs) could trigger instability. Recent research efforts have been made to study the stability issues of the DERs in an ST-fed grid and the corresponding stabilization methods. Differently from the previous investigation focused on the DERs' stability, this paper studies the impacts of the increasing penetration of grid-converter-based devices on the ST low voltage side converter, in particular ...
Tópico(s): HVDC Systems and Fault Protection
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Levy F. Costa, Felix Hoffmann, Giampaolo Buticchi, Marco Liserre,
In this paper, the quadruple active bridge (QAB) dc–dc converter is proposed to be used as a building block to implement the dc–dc stage of a smart transformer (ST). Different configurations (symmetrical, asymmetrical, and rated for voltage/power) for this converter are considered for investigation. Four different architectures of ST, including one based on the dual active bridge converter as a benchmark and three based on the QAB converter, are presented and compared in terms of cost, efficiency, ...
Tópico(s): Semiconductor materials and devices
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Produção Nacional
Revisado por pares
Michele Fornaro, Domenico De Berardis, Giampaolo Perna, Marco Solmi, Nicola Veronese, Laura Orsolini, Elisabetta Filomena Buonaguro, Felice Iasevoli, Cristiano A. Köhler, André F. Carvalho, Andrea de Bartolomeis,
Introduction . A burgeoning number of systematic reviews considering lurasidone in the treatment of bipolar depression have occurred since its Food and Drug Administration extended approval in 2013. While a paucity of available quantitative evidence still precludes preliminary meta-analysis on the matter, the present quality assessment of systematic review of systematic reviews, nonetheless, aims at highlighting current essential information on the topic. Methods . Both published and unpublished systematic ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2017 - Hindawi Publishing Corporation | BioMed Research International
Vito Giuseppe Monopoli, Youngjong Ko, Giampaolo Buticchi, Marco Liserre,
This paper analyzes the performances of different carrier phase-shifting pulse width modulation (PWM) techniques to be used with a multilevel cascaded H-bridge converter in case of unbalanced operational conditions. In fact, in many practical applications, the ideal condition of equal dc voltages and equal reference signals for each H-bridge cannot be achieved. In such conditions, the conventional carrier phase-shifting PWM technique loses its harmonic canceling capabilities and then the multilevel ...
Tópico(s): Microgrid Control and Optimization
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Ambra Bisio, Ludovico Pedullà, Laura Bonzano, Andrea Tacchino, Giampaolo Brichetto, Marco Bove,
Abstract Handwriting is an important activity of daily living, which requires sensorimotor and cognitive skills that could deteriorate in presence of neurological diseases. Handwriting impairments are common in people with multiple sclerosis (PwMS). Aims of the present study were to characterize handwriting movement features of PwMS in comparison with those of healthy adults, and to evaluate the relationship between kinematic parameters of handwriting movements and the results of the assessment of ...
Tópico(s): Assistive Technology in Communication and Mobility
2017 - Nature Portfolio | Scientific Reports
Chandan Kumar, Rongwu Zhu, Giampaolo Buticchi, Marco Liserre,
A smart transformer (ST), which is a power-electronic-based transformer with control and communication functionalities, can be the optimal solution for integrating a battery energy storage system (BESS) in an electric distribution system. In fact, a comparison of energy efficiency for the conventional BESS and the ST-based BESS is carried out, which demonstrates that the ST-based BESS operation is more efficient during charging and discharging, as compared to the conventional BESS. It has been shown ...
Tópico(s): Advanced DC-DC Converters
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Levy F. Costa, Giampaolo Buticchi, Marco Liserre,
The series-resonant converter (SRC) has been used in several application and it recently became popular for smart transformers (STs). In this application, the efficiency and reliability are of paramount importance. Although many papers have addressed the design challenges to improve the converter efficiency, discussions about the reliability are still missing in the literature. In this context, this paper presents a design procedure focusing on the efficiency and reliability improvement of the SRC ...
Tópico(s): Wireless Power Transfer Systems
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Youngjong Ko, Markus Andresen, Giampaolo Buticchi, Marco Liserre,
Modular power converters are expected to play a major role in medium- and high-voltage/power applications. Normally, each module processes the same amount of power; however, this does not take into consideration that different modules can have a different remaining useful lifetime. This paper proposes the concept of power routing for cascaded H-bridge (CHB) converters, with the purpose of delaying the failure of the system. A third-harmonic injection into the duty cycles allows extending the imbalance ...
Tópico(s): HVDC Systems and Fault Protection
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Frederik Hahn, Markus Andresen, Giampaolo Buticchi, Marco Liserre,
The modular multilevel converter (MMC) has become a very attractive solution for interfacing high voltages in hybrid networks. The MMC enables scalability to different power levels, full controllability provided by insulated-gate bipolar transistors, and can achieve very high efficiencies by using a low-switching-frequency method as the nearest level modulation. However, the nearest level modulation requires a capacitor voltage-balancing algorithm, which can result in unbalanced loading for the power ...
Tópico(s): High-Voltage Power Transmission Systems
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Levy F. Costa, Giampaolo Buticchi, Marco Liserre,
The series-resonant dc-dc converter (SRC) is widely applied in a large range of voltage and power. In most applications, fault tolerance is a highly desired feature and it is obtained through redundancy. This paper proposes a fault-tolerance solution for the SRC, which could drastically reduce the need of redundancy. Using the proposed scheme, the full-bridge-based SRC or multilevel-based SRC can be reconfigured in a half-bridge topology, in order to keep the converter operational even with the failure ( ...
Tópico(s): HVDC Systems and Fault Protection
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industry Applications
Levy F. Costa, Giovanni De Carne, Giampaolo Buticchi, Marco Liserre,
The solid-state transformer (SST) was conceived as a replacement for the conventional power transformer, with both lower volume and weight. The smart transformer (ST) is an SST that provides ancillary services to the distribution and transmission grids to optimize their performance. Hence, the focus shifts from hardware advantages to functionalities. One of the most desired functionalities is the dc connectivity to enable a hybrid distribution system. For this reason, the ST architecture shall be ...
Tópico(s): Advanced DC-DC Converters
2017 - Institute of Electrical and Electronics Engineers | IEEE Power Electronics Magazine
Johannes Falck, Giampaolo Buticchi, Marco Liserre,
The reliable operation of the power electronics system of an electric drive is a critical design target. Thermal cycling of the semiconductors in the power module is one of the main stressors. Active thermal control is a possibility to control the junction temperatures of power modules in order to reduce the thermal stress. In this paper, the finite control set model predictive control is designed for thermal stress based driving of electric drives converters. The optimal switching vector is selected ...
Tópico(s): Advanced DC-DC Converters
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industry Applications
Markus Andresen, Vivek Raveendran, Giampaolo Buticchi, Marco Liserre,
The use of a smart transformer-based electrical distribution could be an effective approach to reorganizing the electric grid and solving the problems and challenges of distributed generation systems and active loads. While lower efficiency and higher cost compared with the conventional transformer are well known and investigated limiting factors, the required higher maintenance, related to the use of electronics systems in the electric grid, is seldom targeted. In fact, high maintenance cost would ...
Tópico(s): HVDC Systems and Fault Protection
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Zhixiang Zou, Giampaolo Buticchi, Marco Liserre,
The stability of the grid-connected inverters adopted in distributed energy resources (DERs) highly depends on the characteristics of the grid impedance. Hence, various active damping methods and adaptive control algorithms have been proposed for the control of the grid inverters. Differently from those existing solutions, this paper proposes to use a smart transformer (ST) to shape the grid impedance to interact with the controllers of local inverters, aiming at improving the stability of the local ...
Tópico(s): Advanced DC-DC Converters
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Rongwu Zhu, Giampaolo Buticchi, Marco Liserre,
High-frequency (HF) switching and ac-side unbalanced loads challenge smart transformer (ST)-fed hybrid grids (both ac and dc), causing common-mode (CM) voltage variations and dc-link oscillation. The HF switching introduces an HF CM voltage and the ac grid unbalanced loads introduce a fundamental frequency CM voltage in hybrid grids. The CM voltage in ST-fed distributed grids degrades the power quality, threatens the safety of the connected devices, and potentially constitutes a health risk for the ...
Tópico(s): Microgrid Control and Optimization
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Youngjong Ko, Holger Jedtberg, Giampaolo Buticchi, Marco Liserre,
Back-to-back converters for wind turbine systems feature capacitors in the dc-link to maintain a stable voltage and to decouple a generator from the electric grid. The electrolytic capacitors are typically chosen for their advantages; a higher energy density and a higher capacitance at lower costs. Long-term field experiences and recorded failure data revealed that the capacitors are one of the most frequent failure reasons for the wind turbine system. The current profile of the capacitors is highly ...
Tópico(s): Advanced Battery Technologies Research
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Zhixiang Zou, Giovanni De Carne, Giampaolo Buticchi, Marco Liserre,
The smart transformer (ST), a solid-state transformer with control and communication functionalities, that interfaces medium voltage (MV) and low voltage (LV) grids, enables the control of the frequency in the LV grid independently from the MV one. In a ST-fed distribution grid, the ST can interact with the droop controllers of local generators and loads frequency characteristic to control the LV power demand. However, most of the existing controllers for power converters cannot guarantee good harmonic ...
Tópico(s): Islanding Detection in Power Systems
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Youngjong Ko, Markus Andresen, Giampaolo Buticchi, Marco Liserre,
A widely adopted multilevel converter topology is the cascaded H-bridge (CHB), as it can provide voltage and power scalability. However, since the CHB converter can be composed by cells with different remaining lifetime, it could be useful to delay a fault of higher aged cells in order to prolong the entire converter's lifetime. In this paper, a thermally compensated discontinuous pulse width modulation (DPWM) strategy is proposed in order to reduce the thermal stress for power semiconductors in power ...
Tópico(s): Silicon Carbide Semiconductor Technologies
2017 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Riccardo Schiavina, Andrea Mari, Alessandro Antonelli, Riccardo Bertolo, Giampaolo Bianchi, Marco Borghesi, Eugenio Brunocilla, Cristian Fiori, Nicola Longo, Giuseppe Martorana, Vincenzo Mirone, Giuseppe Morgia, Giacomo Novara, F. Porpiglia, B. Rovereto, Sergio Serni, Claudio Simeone, M. Sodano, Carlo Terrone, Marco Carini, Andrea Minervini,
Introduction: Nephron-sparing surgery (NSS) has become the standard of care for the surgical management of small and clinically localized renal cell carcinoma (RCC).The conservative management of those RCCs is increasing over time.Aim of this study was to report a snapshot of the clinical, perioperative and oncological results after NSS for RCC in Italy.Material and methods: We evaluated all patients who underwent conservative surgical treatment for renal tumours between January 2009 and December ...
Tópico(s): Renal and related cancers
2014 - Elsevier BV | European Journal of Surgical Oncology