Marco Ladetto, Mara Compagno, Irene Ricca, Marco Pagano, Alberto Rocci, Monica Astolfi, Daniela Drandi, Paola Francia di Celle, Maria Elena Dell’Aquila, Barbara Mantoan, Sonia Vallet, G Pagliano, Federica De Marco, Roberto Francese, Loredana Santo, Alessandra Cuttica, Carlo Marinone, Mario Boccadoro, Corrado Tarella,
In this study we investigated telomere restriction fragment (TRF) length in a panel of mature B-cell lymphoproliferative disorders (MBCLDs) and correlated this parameter with histology and histopathogenesis in relation to the germinal center (GC). We assessed 123 MBCLD samples containing 80% or more tumor cells. TRF length was evaluated by Southern blot analysis using a chemiluminescence-based assay. GC status was assessed through screening for stable and ongoing somatic mutations within the immunoglobulin ...
Tópico(s): Cytomegalovirus and herpesvirus research
2004 - Elsevier BV | Blood
Concetta Ruocco, Benedetta de Caprariis, Vincenzo Palma, A. Petrullo, Antonio Ricca, Marco Scarsella, Paolo De Filippis,
Dry reforming could become an effective route to mitigate CO2 emission. The process required high temperatures due to its endothermicity and its accompanied by coke formation; therefore, the development of suitable catalysts is fundamental. In this work, ternary perovskites type oxides, AZrRuO3, were synthetized and used in the methane dry reforming. The influences of the preparation method, modified citrate and autocombustion method, and of substitution of the A cation within alkaline earth metals ( ...
Tópico(s): Catalytic Processes in Materials Science
2019 - Elsevier BV | Journal of CO2 Utilization
Filippo Ricca, Marco Torchiano, Maurizio Leotta, Alessandro Tiso, Giovanna Guerrini, Gianna Reggio,
Context: Model-driven approaches are well-known in the academia but one possible showstopper to a wider adoption in the industry is the limited empirical evidence for their claimed advantages and benefits, that could convince the decision makers. Objective: The aim of this work is gauging one of the claimed benefits of model-driven approaches, namely improvement in maintainability, with respect to a code-centric approach. Method: We conducted a family of five experiments involving 100 students that ...
Tópico(s): Advanced Software Engineering Methodologies
2017 - Springer Science+Business Media | Empirical Software Engineering
Vincenzo Palma, Antonio Ricca, Marco Martino, Eugenio Meloni,
The use of structured catalysts based on highly conductive carriers may allow a flattened radial temperature gradient along the catalytic bed due to a better heat transfer, so obtaining a consequently higher performance. The effect of thermal conductivity of structured carriers on highly endothermic Methane Steam Reforming (MSR) reaction is investigated. The performance of the structured catalysts, prepared starting by Silicon Carbide (SiC) monoliths, in the "wall flow" (WF) and "flow through" (FT) geometric ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2017 - Elsevier BV | Chemical Engineering and Processing - Process Intensification
Mariano Ceccato, Massimiliano Di Penta, Paolo Falcarin, Filippo Ricca, Marco Torchiano, Paolo Tonella,
Context: code obfuscation is intended to obstruct code understanding and, eventually, to delay malicious code changes and ultimately render it uneconomical. Although code understanding cannot be completely impeded, code obfuscation makes it more laborious and troublesome, so as to discourage or retard code tampering. Despite the extensive adoption of obfuscation, its assessment has been addressed indirectly either by using internal metrics or taking the point of view of code analysis, e.g., considering ...
Tópico(s): Security and Verification in Computing
2013 - Springer Science+Business Media | Empirical Software Engineering
Filippo Ricca, Marco Torchiano, Massimiliano Di Penta, Mariano Ceccato, Paolo Tonella,
Tópico(s): Software Testing and Debugging Techniques
2008 - Elsevier BV | Information and Software Technology
G. Gatto, Teresa Ricca, Marco Randazzo, Sonia Di Piazza, Alberto Maringhini, Giovanna Di Trapani, P. Baccelliere, L.M. Montalbano, Luca Barresi,
Tópico(s): Microscopic Colitis
1992 - Elsevier BV | Current Therapeutic Research
Fikru Getachew Debele, Michela Meo, Daniela Renga, Marco Ricca, Yi Zhang,
Being cheap and easy to deploy, dense WLANs are becoming the most popular solution to providing Internet access in locations where the population of users is large, such as on campuses, large enterprises, etc. The large density of access points (APs) comes from the need to have enough capacity to carry the traffic generated at peak hours although, in these scenarios, traffic varies a lot on a daily, weekly, or seasonal basis. During low or no traffic periods, APs are underutilized, even if they are ...
Tópico(s): Advanced Wireless Network Optimization
2015 - Institute of Electrical and Electronics Engineers | IEEE Journal on Selected Areas in Communications
Fatemeh Ganji, Łukasz Budzisz, Fikru Getachew Debele, Nanfang Li, Michela Meo, Marco Ricca, Yi Zhang, Adam Wolisz,
The past years have witnessed a significant increase in the number of WLANs deployed in most of the enterprises, campuses and public areas to provide high-speed Internet connectivity. These WLANs typically consist of APs densely installed to assure enough capacity to meet users demand during the peak period of activity. At the same time, it translates into a serious energy wastage during low-utilization periods, when capacity is not needed at the APs. To reduce this wastage, many proposed solutions ...
Tópico(s): Caching and Content Delivery
2014 - Elsevier BV | Computer Networks
Fikru Getachew Debele, Nanfang Li, Michela Meo, Marco Ricca, Yi Zhang,
WLAN becomes a necessary facility for exible Internet provisioning in enterprise networks. Usually this connection provisioning is designed to handle a peak load with high density of Access Points (APs) to guarantee a desired level of quality of service (QoS). This design approach however leads to energy inefficiency due to the daily demand variability. In fact the off-peak period of the daily behavior is usually quite long and hence some resources consume power without any beneficiary activity. Resource- ...
Tópico(s): Network Traffic and Congestion Control
2014 - Association for Computing Machinery | ACM SIGMETRICS Performance Evaluation Review
Marco Ladetto, Sonia Vallet, Andreas Trojan, Maria Elena Dell’Aquila, Luigia Monitillo, Rosalba Rosato, Loredana Santo, Daniela Drandi, Alessandra Bertola, Patrizia Falco, Federica Cavallo, Irene Ricca, Federica De Marco, Barbara Mantoan, Beata Bode‐Lesniewska, G Pagliano, Roberto Francese, Alberto Rocci, Monica Astolfi, Mara Compagno, Sara Mariani, Laura Godio, Lydia Marino, Marina Ruggeri, Paola Omedè, Antonio Palumbo, Mario Boccadoro,
Cyclooxygenase 2 (COX-2) is an inflammation-associated enzyme involved in the pathogenesis of many solid tumors, but little is known about its presence and role in hematologic neoplasms. Multiple myeloma (MM) is known to involve a deregulated cytokine network with secretion of inflammatory mediators. We thus decided to investigate the involvement of COX-2 in this neoplasm. Western blotting (WB) was used to evaluate 142 bone marrow (BM) specimens, including MM and monoclonal gammopathy of undetermined ...
Tópico(s): Peptidase Inhibition and Analysis
2005 - Elsevier BV | Blood
Matteo Nicola Dario Di Minno, Mariasanta Napolitano, Anna Chiara Giuffrida, Erminia Baldacci, Christian Carulli, Elena Boccalandro, Clarissa Bruno, Eleonora Forneris, Irene Ricca, Walter Passeri, Marco Martinelli, Gianna Franca Rivolta, Luigi Piero Solimeno, Carlo Martinoli, Angiola Rocino, Gianluigi Pasta,
Although synovitis is recognized as a marker of joint disease activity, its periodic assessment is not included in routine clinical surveillance of patients with haemophilia (PwH). In order to evaluate the current knowledge and to identify controversial issues, a preliminary literature search by the Musculoskeletal Committee of the Italian Association of Haemophilia Centres (AICE) has been conducted. Statements have been established and sent to the Italian AICE members to collect their level of agreement ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2021 - Wiley | British Journal of Haematology
Produção Nacional
Revisado por pares
Angelica D’Amore, Alessandra Tessa, Carlo Casali, Maria Teresa Dotti, Alessandro Filla, Gabriella Silvestri, Antonella Antenora, Guja Astrea, Melissa Barghigiani, Roberta Battini, Carla Battisti, Irene Bruno, Cristina Cereda, Clemente Dato, Giuseppe Di Iorio, Vincenzo Donadio, Monica Felicori, Nicola Fini, Chiara Fiorillo, Salvatore Gallone, Federica Gemignani, Gian Luigi Gigli, Claudio Graziano, Renzo Guerrini, Fiorella Gurrieri, Ariana Kariminejad, Maria Lieto, Charles Marques Lourenço, Alessandro Malandrini, Paola Mandich, Christian Marcotulli, Francesco Mari, Luca Massacesi, Mariarosa Anna Beatrice Melone, Andrea Mignarri, Roberta Milone, Olimpia Musumeci, Elena Pegoraro, Alessia Perna, Antonio Petrucci, Alessandro Pini, Francesca Pochiero, Maria Roser Pons, Ivana Ricca, Salvatore Rossi, Marco Seri, Franco Stanzial, Francesca Tinelli, António Toscano, Mariarosaria Valente, Antonio Federico, Anna Rubegni, Filippo M. Santorelli,
Hereditary spastic paraplegia (HSP) refers to a group of genetically heterogeneous neurodegenerative motor neuron disorders characterized by progressive age-dependent loss of corticospinal motor tract function, lower limb spasticity, and weakness. Recent clinical use of next generation sequencing (NGS) methodologies suggests that they facilitate the diagnostic approach to HSP, but the power of NGS as a first-tier diagnostic procedure is unclear. The larger-than-expected genetic heterogeneity-there ...
Tópico(s): Neurological diseases and metabolism
2018 - Frontiers Media | Frontiers in Neurology
Benedetta de Caprariis, Paolo De Filippis, Vincenzo Palma, A. Petrullo, Antonio Ricca, Concetta Ruocco, Marco Scarsella,
In recent years dry reforming of methane has received considerable attention as a promising alternative to steam reforming for synthesis gas (H2 and CO) production, yielding a syngas with a H2/CO ratio close to 1 and thus suitable for many chemical processes. The major drawback of the process is the endothermicity of the reaction that implies the use of a suitable catalyst to work at relatively low temperatures (923–1023 K). In this work methane dry reforming over three ternary perovskite type oxides ...
Tópico(s): Catalysis and Oxidation Reactions
2016 - Elsevier BV | Applied Catalysis A General
Antonio Ricca, Vincenzo Palma, Marco Martino, Eugenio Meloni,
Tópico(s): Catalysis and Hydrodesulfurization Studies
2016 - Elsevier BV | Fuel
Filippo Ricca, Giuseppe Scanniello, Marco Torchiano, Gianna Reggio, Egidio Astesiano,
Over the last few years, the software engineering community has proposed a number of modeling methods to represent functional requirements. Among them, use cases are recognized as an easy to use and intuitive way to capture and define such requirements. Screen mockups (also called user-interface sketches or user interface-mockups) have been proposed as a complement to use cases for improving the comprehension of functional requirements. In this article, we aim at quantifying the benefits achievable ...
Tópico(s): Advanced Software Engineering Methodologies
2014 - Association for Computing Machinery | ACM Transactions on Software Engineering and Methodology
Filippo Ricca, Alessandro Marchetto, Marco Torchiano,
In spite of the potential relevance for managers and even though the Truck Factor definition is well-known in the "agile world" for many years, shared and validated measurements, algorithms, tools, thresholds and empirical studies on this topic are still lacking. In this paper, we explore the situation implementing the only approach proposed in literature able to compute the Truck Factor. Then, using our tool, we conduct an exploratory study with 37 open source projects for discovering limitations ...
Tópico(s): Open Source Software Innovations
2011 - Springer Science+Business Media | Lecture notes in computer science
Irene Ricca, Mara Compagno, Marco Ladetto, Albero Rocci, Maria Elena Dell’Aquila, Paola Omedè, F De Marco, Sergio D’Antico, Daniele Caracciolo, Dario Ferrero, Carmelo Carlo‐Stella, Corrado Tarella,
The purpose of the study was to compare telomere length (TL) in peripheral blood progenitor cells (PBPC) collected after two tightly spaced high-dose (hd) chemotherapy courses. We assessed 37 previously untreated lymphoma patients undergoing a hd-chemotherapy program with autografting. They sequentially received hd-cyclophosphamide (CY) and hd-Ara-C, both followed by PBPC harvesting. Both post-CY and post-Ara-C harvests were assessed for TL by Southern blot analysis. In 12 patients, the assay was also ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2005 - Springer Nature | Leukemia
Luisa Tondelli, Alfredo Ricca, Michele Laus, Marco Lelli, Gennaro Citro,
c-myb antisense oligonucleotides (AS ODNs) were reversibly immobilized to a novel polymeric core shell nanosphere and their cellular uptake and inhibitory effect on HL60 leukemia cell proliferation studied. The nanosphere surface was so designed as to directly bind ODNs via ionic interactions and reversibly release them inside the cells. Compared with the cellular uptake of free oligonucleotide, the use of AS ODN (immobilized to the nanospheres) produced a 50-fold increase in the intracellular concentration. ...
Tópico(s): DNA and Nucleic Acid Chemistry
1998 - Oxford University Press | Nucleic Acids Research
Luciana Randazzo, Michela Ricca, Silvestro Antonio Ruffolo, Marco Aquino, Barbara Davidde Petriaggi, Flavio Enei, Mauro Francesco La Russa,
This paper aims to carry out an archaeometric characterization of mortar samples taken from an underwater environment. The fishpond of the archaeological site of Castrum Novum (Santa Marinella, Rome, Italy) was chosen as a pilot site for experimentation. The masonry structures reached the maximum thickness at the apex of the fishpond (4.70 m) and consisted of a concrete conglomerate composed of slightly rough stones of medium size bound with non-hydraulic mortar. After sampling, for a complete characterization ...
Tópico(s): Conservation Techniques and Studies
2019 - Multidisciplinary Digital Publishing Institute | Minerals
Filippo Ricca, Massimiliano Di Penta, Marco Torchiano, Paolo Tonella, Mariano Ceccato,
In recent years, several design notations have been proposed to model domain-specific applications or reference architectures. In particular, Conallen has proposed the UML Web Application Extension (WAE): a UML extension to model Web applications. The aim of our empirical investigation is to test whether the usage of the Conallen notation supports comprehension and maintenance activities with significant benefits, and whether such benefits depend on developers ability and experience. This paper reports ...
Tópico(s): Software Engineering Techniques and Practices
2009 - IEEE Computer Society | IEEE Transactions on Software Engineering
Andrea Bianco, Paolo Giaccone, Marco Ricca,
Optical switching is a promising technology to scale the performance of data centers. We address two scenarios: hybrid data centers, in which an optical circuit switching network operates in parallel to an electronic packet switching network that interconnect the servers, and full optical data centers, in which all the traffic is switched in the optical domain. The traffic on the optical network is scheduled proactively by configuring the optical fabric according to a precomputed sequence of configurations. ...
Tópico(s): Semiconductor Lasers and Optical Devices
2016 - Elsevier BV | Computer Networks
Marco Ruella, Alberto Rocci, Irene Ricca, Cristiana Carniti, C Labetti Bodoni, Marco Ladetto, Daniele Caracciolo, Mario Boccadoro, Carmelo Carlo‐Stella, Paolo Corradini, Corrado Tarella,
Tópico(s): Tissue Engineering and Regenerative Medicine
2009 - Springer Nature | Bone Marrow Transplantation
Pietro Giuseppe Mazzara, Luca Massimino, Marta Pellegatta, Giulia Ronchi, A Ricca, Angelo Iannielli, Serena Giannelli, Marco Cursi, Cinzia Cancellieri, Alessandro Sessa, Ubaldo Del Carro, Angelo Quattrini, Stefano Geuna, Angela Gritti, Carla Taveggia, Vania Broccoli,
Abstract Schwann cells (SCs) generate the myelin wrapping of peripheral nerve axons and are promising candidates for cell therapy. However, to date a renewable source of SCs is lacking. In this study, we show the conversion of skin fibroblasts into induced Schwann cells (iSCs) by driving the expression of two transcription factors, Sox10 and Egr2. iSCs resembled primary SCs in global gene expression profiling and PNS identity. In vitro , iSCs wrapped axons generating compact myelin sheaths with regular ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2017 - Nature Portfolio | Nature Communications
Francesco Ricca, Giovanni Grasso, Mario Alviano, Marco Manna, Vincenzino Lio, Salvatore Iiritano, Nicola Leone,
Abstract The seaport of Gioia Tauro is the largest transshipment terminal of the Mediterranean coast. A crucial management task for the companies operating in the seaport is team-building: the problem of properly allocating the available personnel for serving the incoming ships. Teams have to be carefully arranged in order to meet several constraints, such as allocation of employees with appropriate skills, fair distribution of the working load, and turnover of the heavy/dangerous roles. This makes ...
Tópico(s): Constraint Satisfaction and Optimization
2011 - Cambridge University Press | Theory and Practice of Logic Programming
Alfredo Ricca, Annamaria Biroccio, Daniela Trisciuoglio, Marco Cippitelli, Gabriella Zupi, Donatella Del Bufalo,
We previously demonstrated that bcl-2 over-expression increases the malignant behaviour of the MCF7 ADR human breast cancer cell line and enhances nuclear factor-kappa B (NF-kB) transcriptional activity. Here, we investigated the direct effect of increased NF-kB activity on the tumorigenicity of MCF7 ADR cells by over-expressing the NF-kB subunit relA/p65. Surprisingly, our results demonstrated that over-expression of relA determines a considerable reduction of the tumorigenic ability in nude mice ...
Tópico(s): interferon and immune responses
2001 - Springer Nature | British Journal of Cancer
Gaetano Isola, Angela Alibrandi, Monica Currò, Marco Matarese, Sergio Ricca, Giovanni Matarese, Riccardo Ientile, Thomas Kocher,
Asymmetric dimethylarginine (ADMA) plays a crucial role in endothelial function and maybe a link for the known interaction of periodontitis and coronary heart disease (CHD). In this pilot study, we compared the impact of gingival health, periodontitis (CP), CHD, or of both diseases (CP + CHD) on salivary and serum ADMA levels.The clinical and periodontal characteristics, serum, and saliva samples were collected from 35 patients with CP, 33 patients with CHD, 35 patients with both CP + CHD, and 35 healthy ...
Tópico(s): Inflammatory mediators and NSAID effects
2020 - Wiley | Journal of Periodontology
Eugenio Meloni, Marco Martino, Antonio Ricca, Vincenzo Palma,
Hydrogen is a potential green energy vector. Since the heating of the reforming processes commonly used for its production is obtained by burning hydrocarbons, it has a substantial CO2 footprint. One of the most critical aspects in the methane steam reforming (MSR) reaction is the heat transfer to the catalytic volume, due to the high heat fluxes required to obtain high methane conversions. Consequently, the reactor has complex geometries, along with the heating medium being characterized by temperatures ...
Tópico(s): Catalytic Processes in Materials Science
2020 - Elsevier BV | International Journal of Hydrogen Energy
Martin Gebser, Marco Maratea, Francesco Ricca,
Abstract Answer Set Programming (ASP) is a prominent knowledge representation language with roots in logic programming and non-monotonic reasoning. Biennial ASP competitions are organized in order to furnish challenging benchmark collections and assess the advancement of the state of the art in ASP solving. In this paper, we report on the design and results of the Seventh ASP Competition, jointly organized by the University of Calabria (Italy), the University of Genova (Italy), and the University of ...
Tópico(s): Advanced Algebra and Logic
2019 - Cambridge University Press | Theory and Practice of Logic Programming
Mario Alviano, Giovanni Amendola, Carmine Dodaro, Nicola Leone, Marco Maratea, Francesco Ricca,
Answer Set Programming (ASP) is a well-established declarative programming language based on logic. The success of ASP is mainly due to the availability of efficient ASP solvers, therefore their development is still an important research topic. In this paper we report the recent improvements of the well-known ASP solver wasp. The new version of wasp includes several improvements of the main solving strategies and advanced reasoning techniques for computing paracoherent answer sets. Indeed, wasp is ...
Tópico(s): Logic, programming, and type systems
2019 - Springer Science+Business Media | Lecture notes in computer science