David Roura‐Martínez, Marcos Ucha, Javier Orihuel, Inmaculada Ballesteros‐Yáñez, Carlos Alberto Castillo, Alberto Marcos, Emilio Ambrosio, Alejandro Higuera‐Matas,
Abstract Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues—incubation of drug craving—has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug withdrawal (or using a natural reinforcer). Although much progress has been made, an integrated approach simultaneously studying different drug classes and natural reward and ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - Wiley | Addiction Biology
Santiago M. Coria, David Roura‐Martínez, Marcos Ucha, María Amparo Assis, Miguel Miguéns, Carmen Garcı́a-Lecumberri, Alejandro Higuera‐Matas, Emilio Ambrosio,
The Lewis (LEW) and Fischer 344 (F344) rat strains have been proposed as a model to study certain genetic influences on drug use. These strains differ in terms of the self-administration of several drugs, and in their expression of various components of the dopaminergic, glutamatergic, GABAergic and endogenous opioid neurotransmitter systems. As the endocannabinoid system is linked to these systems, we investigated whether these two strains exhibit differences in cannabinoid receptor binding and in ...
Tópico(s): Neuroscience and Neuropharmacology Research
2014 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Javier Orihuel, Roberto Capellán, David Roura‐Martínez, Marcos Ucha, Emilio Ambrosio, Alejandro Higuera‐Matas,
Abstract Background Cannabis exposure during adolescence is associated with emotional and motivational alterations that may entail an enhanced risk of developing psychiatric disorders. In rodent models, exposure to cannabinoids during adolescence leads to increased self-administration of opiates and cocaine, however, the psychological and neural mechanisms and the sex-specificity of this phenomenon are largely unknown. Methods We exposed male and female adolescent rats to Δ9-tetrahydrocannabinol ( ...
Tópico(s): Neuroscience and Neuropharmacology Research
2021 - University of Oxford | The International Journal of Neuropsychopharmacology
Marcos Ucha, David Roura‐Martínez, Emilio Ambrosio, Alejandro Higuera‐Matas,
Exposure to drugs of abuse induces neuroadaptations in critical nodes of the so-called reward systems that are thought to mediate the transition from controlled drug use to the compulsive drug-seeking that characterizes addictive disorders. These neural adaptations are likely to require protein synthesis, which is regulated, among others, by the mechanistic target of the rapamycin kinase (mTOR) signalling cascade.We have performed a narrative review of the literature available in PubMed about the ...
Tópico(s): Ion channel regulation and function
2020 - SAGE Publishing | Journal of Psychopharmacology
María J. Simón, Alejandro Higuera‐Matas, David Roura‐Martínez, Marcos Ucha, Raquel Santos‐Toscano, Carmen Garcı́a-Lecumberri, Emilio Ambrosio, Amadeo Puerto,
Intracranial self-stimulation (ICSS) of the lateral hypothalamus (LH) is involved in the activation of neuroanatomical systems that are also associated with the processing of natural and other artificial rewarding stimuli. Specific components of this behavior (hedonic impact, learning, and motor behavior) may involve changes in different neurotransmitters, such as dopamine and opioids. In this study, quantitative autoradiography was used to examine changes in mu-opioid and D1/D2-dopamine receptor expression ...
Tópico(s): Sleep and Wakefulness Research
2015 - Elsevier BV | Neurobiology of Learning and Memory
Marcos Ucha, David Roura‐Martínez, Ana Contreras, Sheyla Pinto-Rivero, Javier Orihuel, Emilio Ambrosio, Alejandro Higuera‐Matas,
The orbitofrontal cortex (OFC) is a key brain region for decision-making, action control and impulsivity. Quite notably, previous research has identified a double dissociation regarding the role of this cortical territory in impulsive choice. While medial orbitofrontal lesions increase preference for a large but delayed reward, lateral orbitofrontal lesions have the opposite effect. However, there are no data regarding this anatomical dissociation in impulsive action. The neurochemical basis of impulsivity ...
Tópico(s): Memory and Neural Mechanisms
2019 - Frontiers Media | Frontiers in Behavioral Neuroscience
David Roura‐Martínez, Paula Díaz-Bejarano, Marcos Ucha, Raquel R. Paiva, Emilio Ambrosio, Alejandro Higuera‐Matas,
Relapse into drug use is a significant problem for people recovering from addiction. The ability that conditioned cues have to reinstate and reinvigorate drug-seeking is potentiated over time (incubation of seeking), posing an additional difficulty for maintaining abstinence. While the prefrontal cortex has been involved in the incubation phenomenon and the extracellular matrix, perineuronal nets (PNNs) in particular, may play a vital role in brain plasticity associated to drug relapse, there are ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2020 - Elsevier BV | Neuropharmacology
Roberto Capellán, Mario G. Moreno, Javier Orihuel, David Roura‐Martínez, Marcos Ucha, Emilio Ambrosio, Alejandro Higuera‐Matas,
Prenatal infections are environmental risk factors for neurodevelopmental disorders. In addition, traumatic experiences during adolescence in individuals exposed to infections during gestation could increase the risk of schizophrenia. It is of the most crucial importance to discover potential markers of the disease in its early stages or before its onset, so that therapeutic strategies may be implemented. In the present study, we combined a proposed two-hit model of schizophrenia-related symptoms ...
Tópico(s): Gut microbiota and health
2019 - Elsevier BV | Schizophrenia Research
Raquel Santos‐Toscano, Érika Borcel, Marcos Ucha, Javier Orihuel, Roberto Capellán, David Roura‐Martínez, Emilio Ambrosio, Alejandro Higuera‐Matas,
Although cocaine abuse is up to three times more frequent among schizophrenic patients, it remains unclear why this should be the case and whether sex influences this relationship. Using a maternal immune activation model of schizophrenia, we tested whether animals at higher risk of developing a schizophrenia-like state are more prone to acquire cocaine self-administration behavior, and whether they show enhanced sensitivity to the reinforcing actions of cocaine or if they are resistant to extinction. ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2016 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Javier Orihuel, Laura Gómez-Rubio, Claudia Valverde, Roberto Capellán, David Roura‐Martínez, Marcos Ucha, Emilio Ambrosio, Alejandro Higuera‐Matas,
It has been suggested that cannabis consumption during adolescence may be an initial step to cocaine use in adulthood. Indeed, previous preclinical data show that adolescent exposure to cannabinoids (both natural and synthetic) potentiates cocaine self-administration in rats. Here we aimed at gaining a deeper understanding of the cellular activation patterns induced by cocaine as revealed by Fos imaging and how these patterns may change due to adolescent exposure to THC. Male and female Wistar rats ...
Tópico(s): Neuroscience and Neuropharmacology Research
2021 - Elsevier BV | Brain Research
Marcos Ucha, Santiago M. Coria, Adrián E Núñez, Raquel Santos‐Toscano, David Roura‐Martínez, Javier Fernández‐Ruíz, Alejandro Higuera‐Matas, Emilio Ambrosio,
Addiction is a chronic disorder with a high risk of relapse. The neural mechanisms mediating addictions require protein synthesis, which could be relevant for the development of more effective treatments. The mTOR signaling pathway regulates protein synthesis processes that have recently been linked to the development of drug addiction.To assess the effects of morphine self-administration and its subsequent extinction on the expression of several genes that act in this pathway, and on the levels ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2019 - SAGE Publishing | Journal of Psychopharmacology
Marcos Ucha, David Roura‐Martínez, Raquel Santos‐Toscano, Roberto Capellán, Emilio Ambrosio, Alejandro Higuera‐Matas,
The development of substance use disorders involves long-lasting adaptations in specific brain areas that result in an elevated risk of relapse. Some of these adaptations are regulated by the mTOR network, a signalling system that integrates extracellular and intracellular stimuli and modulates several processes related to plasticity. While the role of the mTOR network in cocaine- and alcohol-related disorders is well established, little is known about its participation in opiate use disorders.To ...
Tópico(s): Pancreatic function and diabetes
2022 - Springer Science+Business Media | Psychopharmacology
Produção Nacional
Revisado por pares
Patrícia Fernanda Felipe Pinheiro, Tânia Mara Segatelli, C.C.D. Almeida Francia, M. Martinez, Carlos Roberto Padovani, Marcos R. Franchi, Francisco Eduardo Martinez,
The extreme use of ethanol causes metabolic and pathologic changes in testes and urogenital system in different animal species. The enzyme alcohol dehydrogenase (ADH) catalyses the conversion of ethanol into carcinogenic metabolite acetaldehyde which is partly excreted into the urine. However, papers relating the chronic ethanol consumption to the urethral morphology are unknown. This work evaluates the toxic effect of the chronic ethanol ingestion on the urethral epithelium of UChA and UChB rats. ...
Tópico(s): Neuropeptides and Animal Physiology
2007 - Elsevier BV | Micron
Alberto Marcos, Mario G. Moreno, Javier Orihuel, Marcos Ucha, Ana de Paz, Alejandro Higuera‐Matas, Roberto Capellán, Antonio L. Crego, María‐Rosa Martínez‐Larrañaga, Emilio Ambrosio, Arturo Anadón,
Under paradigms of combined intravenous cocaine and ethanol self-administration, the effects on behavior have been poorly explored. Numerous studies have found sex differences in amino acids profile and behavioral responses to each drug, yet few have focused on the interactions between cocaine and ethanol. The main objective of this work was to explore the acquisition and maintenance of intravenous self-administration behavior with a combination of cocaine and ethanol in male and female young adult ...
Tópico(s): Forensic Toxicology and Drug Analysis
2020 - Public Library of Science | PLoS ONE
A. Marcos, Javier Orihuel, Dênis Martinez, Marcos Ucha, Ana Matas, Emilio Ambrosio, Arturo Anadón,
Cocaine addiction is a persistent mental illness and there is no effective therapy so far. The precise mechanisms underlying cocaine addictive responses remain unclear. A growing body of evidence suggests that ion channels in the brain reward circuits are believed to play an important role in cocaine addiction. Recently, proton has been identified as a neurotransmitter and one of the candidates for sensing proton is acid-sensing ion channels (ASICs). ASICs are highly expressed in the brain reward ...
Tópico(s): Receptor Mechanisms and Signaling
2016 - Elsevier BV | Toxicology Letters
David Roura‐Martínez, Marcos Ucha, Santiago M. Coria, Alejandro Higuera‐Matas, Emilio Ambrosio,
The Lewis (LEW) and Fischer 344 (F344) rat strains are widely used as models of genetic vulnerability to drug addiction, par- ticularly since these two strains show different patterns of drug self- administration. We previously performed an unbiased and genome- wide microarray analysis to define the differences in gene expression in the nucleus accumbens (NAcc) and prefrontal cortex between LEW and F344 rats. In this study, we set out to determine the strain differences in the NAcc and amygdala at ...
Tópico(s): Ion channel regulation and function
2014 - | Journal of Drug and Alcohol Research
Natalia de Las Heras-Martínez, Jairo Acosta-Vargas, Marcos Ucha-Tortuero, Alejandro Higuera‐Matas,
Tópico(s): Vaccine Coverage and Hesitancy
2023 - Elsevier BV | IBRO Neuroscience Reports
Mario G. Moreno, Víctor Luján, Shishir Baliyan, Celia Poza, Roberto Capellán, Natalia de Las Heras-Martínez, Miguel A. Morcillo, Marta Oteo, Emilio Ambrosio, Marcos Ucha, Alejandro Higuera‐Matas,
Tópico(s): Birth, Development, and Health
2025 - Elsevier BV | Biological Psychiatry Global Open Science
Jairo Acosta-Vargas, Natalia De Las Heras-Martínez, Lucia Garrido Matilla, María Roca, Natalia Puig Martínez, Mario Moreno Fernández, Ana Belén Sanz Martos, Shishir Baliyan, Marcos Ucha-Tortuero, Alejandro Higuera‐Matas,
Tópico(s): Sex and Gender in Healthcare
2023 - Elsevier BV | IBRO Neuroscience Reports
Juan Carlos Vázquez-Ucha, Alejandro Seoane-Estévez, Bruno K. Rodiño‐Janeiro, Mónica González-Bardanca, Kelly Conde‐Pérez, Marta Martínez-Guitián, Laura Álvarez-Fraga, Jorge Arca-Suárez, Cristina Lasarte-Monterrubio, Marta Gut, Marta Gut, Miguel Álvarez-Tejado, Marina Oviaño, Alejandro Beceiro, Germán Bou, Irene Merino, Emilia Cercenado, Rosa Gómez, Tamara Soler, Irene Gracia-Ahufinger, L. Hibberd Martin, Fátima Galán‐Sánchez, Nuria Tormo, Juan Carlos Rodrı́guez, Sílvia Capilla, Francesc Marco, María Dolores Quesada, Emma Padilla, Fé Tubau, Juanjo González, Ana Isabel López‐Calleja, José Luís del Pozo, María Inmaculada García, Mariela Martínez, Jorge Calvo, Xavier Mulet, F. J. García Peña, Ana Isabel Rodríguez, María José Gude, Ana Fernández‐Palacín, Javier Fernández,
Imipenem/relebactam is a novel carbapenem/β-lactamase inhibitor combination, developed to act against carbapenemase-producing Enterobacterales (CPE).To assess the in vitro activity of imipenem/relebactam against a Spanish nationwide collection of CPE by testing the susceptibility of these isolates to 16 widely used antimicrobials and to determine the underlying β-lactam resistance mechanisms involved and the molecular epidemiology of carbapenemases in Spain.Clinical CPE isolates (n = 401) collected ...
Tópico(s): Pneumonia and Respiratory Infections
2021 - Oxford University Press | Journal of Antimicrobial Chemotherapy
P. Fanlo, Borja Gracia-Tello, Eva Fonseca Aizpuru, Jorge Álvarez Troncoso, Andrés González García, Sergio Prieto‐González, M. Freire, Ana Argibay, Lucio Pallarés, José Todolí, Mercedes Pérez, Segundo Buján-Rivas, Berta Ibáñez, Rubén Arnáez, Elisa Huarte, Julio Sánchez, Eva Zabalza, Ruth Garcia-Rey, Maria Belen Gonzalo, Laura Diez-Galán, Marisa de la Rica Escuín, Luis Martínez‐Lostao, Adela Marín Ballvé, María Luisa Taboada-Martínez, Rubén Pampín Sánchez, Cristina Helguera-Amézua, R. Fernández-Madera-Martínez, Estela García-Coya, Ana María Álvarez-Suarez, Ángel Ricardo Galarza Robles, Ana García‐Noblejas, Clara Soto, Elena Martínez, Francisco Arnalich, Coral Arévalo, Angélica López-Rodríguez, Pilar Cobeta, Fernando José Alcantarilla Hidalgo, Sergio Diz, Paula González, Nuria Bara, M. Fabregate, Judith Jiménez, Svetlana Zhilina Zhilina, Martina Pellicer-Ariño, Olga Núñez, Joan Ribot Grabalosa, Míriam Costafreda-Mas, Adrián Tomé-Pérez, Teresa Hospital-Vidal, Andrea Ladino-Vázquez, Alma Morancho-Sesé, Adelaido Salazar-Rustarazo, Cristina Gabara-Xancó, Arturo Gonzalez -Quintela, B. Sopeña, Rosario Alende -Sixto, Helena Esteban, Nuria Rodríguez‐Núñez, Ariadna Helena Andrade-Piña, Maria Ángeles Sanchidrian-Chapinal, Pablo Varela, Manuel Taboada, Brenda Maure-Noia, Ana López-Domínguez, Carmen Filloy-Mato, Beatriz Gimena-Reyes, Marisol Samartín‐Ucha, C. Vázquez-Triñanes, Julian Fernández-Martín, A Paradela Carreiro, Ana María Regueira‐Arcay, Eva Esteban-Marcos, Luisa Martin-Pena, Juan Antonio Fernández-Navarro, Noelia Abdilla-Bonias, Jaume Mestre-Torres, Joana Marques‐Soares, José Pardos‐Gea,
COVID-19 pneumonia is often associated with hyperinflammation. The efficacy and safety of anakinra in treating patients with severe COVID-19 pneumonia and hyperinflammation are still unclear.To assess the efficacy and safety of anakinra vs standard of care alone for patients with severe COVID-19 pneumonia and hyperinflammation.The Clinical Trial of the Use of Anakinra in Cytokine Storm Syndrome Secondary to COVID-19 (ANA-COVID-GEAS) was a multicenter, randomized, open-label, 2-group, phase 2/3 clinical ...
Tópico(s): Sepsis Diagnosis and Treatment
2023 - American Medical Association | JAMA Network Open
Jorge Arca-Suárez, Bruno K. Rodiño‐Janeiro, Astrid Pérez, Paula Guijarro-Sánchez, Juan Carlos Vázquez-Ucha, Fernando Cruz, Jèssica Gómez‐Garrido, Tyler Alioto, Miguel Álvarez-Tejado, Marta Gut, Marta Gut, Marina Oviaño, Alejandro Beceiro, Germán Bou, Irene Merino, Emilia Cercenado, Rosa Gómez, Tamara Soler, Irene Gracia-Ahufinger, L. Hibberd Martin, Fátima Galán‐Sánchez, Nuria Tormo, Juan Carlos Rodrı́guez, Sílvia Capilla, Francesc Marco, María Dolores Quesada, Emma Padilla, Fé Tubau, Juanjo González, Ana Isabel López‐Calleja, José Luís del Pozo, María Inmaculada García, Mariela Martínez, Jorge Calvo, Xavier Mulet, F. J. García Peña, Ana Isabel Rodríguez, María José Gude, Ana Fernández‐Palacín, Javier Fernández,
Tópico(s): Mycobacterium research and diagnosis
2021 - Elsevier BV | International Journal of Antimicrobial Agents