... Neuroscience: A Role for Brain Imaging Marcus E. Raichle, Marcus E. Raichle 1 Washington University, St. Louis, USA [ ... more papers by this author 1 Marcus E. Raichle, Marcus E. Raichle 1 Washington University, St. Louis, USA [email protected] ...
Tópico(s): Neurobiology of Language and Bilingualism
2003 - Wiley | Political Psychology
... Phrenology: Maps of Human Cortical Function MARCUS E. RAICHLE, MARCUS E. RAICHLE Professor of Radiology, Neurology, and Neurobiology, ... for more papers by this author MARCUS E. RAICHLE, MARCUS E. RAICHLE Professor of Radiology, Neurology, and Neurobiology, Washington University ...
Tópico(s): Functional Brain Connectivity Studies
1999 - Wiley | Annals of the New York Academy of Sciences
Marcus E. Raichle, Joel S. Perlmutter, Peter T. Fox,
... pharmacological approaches with positron emission tomography Marcus E. Raichle MD, Marcus E. Raichle MD Edward Mallinckrodt Institute of Radiology, ... for more papers by this author Marcus E. Raichle MD, Marcus E. Raichle MD Edward Mallinckrodt Institute of Radiology, The McDon ...
Tópico(s): Parkinson's Disease and Spinal Disorders
1984 - Wiley | Annals of Neurology
Joel S. Perlmutter, Marcus E. Raichle,
... 63110Search for more papers by this authorMarcus E. Raichle MD, Marcus E. Raichle MD Washington University School of Medicine, ... 63110Search for more papers by this authorMarcus E. Raichle MD, Marcus E. Raichle MD Washington University School of Medicine, St. Louis, ...
Tópico(s): Retinal Development and Disorders
1986 - Wiley | Annals of Neurology
Michael J. Welch, Marcus E. Raichle, Michael R. Kilbourn, Mark A. Mintun,
... 63110Search for more papers by this authorMarcus E. Raichle MD, Marcus E. Raichle MD Edward Mallinckrodt Institute of Radiology, ... 63110Search for more papers by this authorMarcus E. Raichle MD, Marcus E. Raichle MD Edward Mallinckrodt Institute of Radiology, Washington University ...
Tópico(s): Takotsubo Cardiomyopathy and Associated Phenomena
1984 - Wiley | Annals of Neurology
H. Brent Clark, Hartman Boyd K., Raichle Marcus E., Preskorn Sheldon H., Kenneth B. Larson,
A small volume (5 μl) common carotid arterial injection method is described for the quantitation of cerebral vascular extraction fractions (Et) of diffusion limited tracer molecules in the rat. The method is a modification of a technique diffusion duced by Oldendorf and widely used for the study of blood-brain barrier phenomena. While the Oldendorf technique has proven valuable for estimating the relative permeabilities of substances, it is limited in measuring Et under conditions of physiologically ...
Tópico(s): Neuroscience and Neuropharmacology Research
1981 - Elsevier BV | Brain Research
... Metabolic and Circulatory Requirements of Cognition MARCUS E. RAICHLE, Corresponding Author MARCUS E. RAICHLE Washington University School of Medicine 4525 ... for more papers by this author MARCUS E. RAICHLE, Corresponding Author MARCUS E. RAICHLE Washington University School of Medicine 4525 Scott Avenue ...
Tópico(s): Functional Brain Connectivity Studies
1997 - Wiley | Annals of the New York Academy of Sciences
Noé Brasier, Christina J. Raichle, Marcus Dörr, Adrian Becke, Vivien Nohturfft, Stefan Weber, Fabienne Bulacher, Lorena Salomon, Thierry Noah, Ralf Birkemeyer, Jens Eckstein,
Early detection of atrial fibrillation (AF) is essential for stroke prevention. Emerging technologies such as smartphone cameras using photoplethysmography (PPG) and mobile, internet-enabled electrocardiography (iECG) are effective for AF screening. This study compared a PPG-based algorithm against a cardiologist's iECG diagnosis to distinguish between AF and sinus rhythm (SR). In this prospective, two-centre, international, clinical validation study, we recruited in-house patients with presumed AF ...
Tópico(s): ECG Monitoring and Analysis
2018 - Oxford University Press | EP Europace
Marcus E. Raichle, Peter Herscovitch, Mark A. Mintun, W. R. Wayne Martin, William E. Powers,
... function in humans with positron emission tomography Dr Marcus E. Raichle MD, Corresponding Author Dr Marcus E. Raichle MD Edward Mallinckrodt Institute of Radiology, The McDonnell ... 63110Search for more papers by this author Dr Marcus E. Raichle MD, Corresponding Author Dr Marcus E. Raichle MD Edward Mallinckrodt Institute of Radiology, The McDonnell ...
Tópico(s): Optical Imaging and Spectroscopy Techniques
1984 - Wiley | Annals of Neurology
Michel M. Ter‐Pogossian, David C. Ficke, Mark A. Mintun, Peter Herscovitch, Peter T. Fox, Marcus E. Raichle,
... 63110Search for more papers by this authorMarcus E. Raichle MD, Marcus E. Raichle MD Edward Mallinckrodt Institute of Radiology, ... 63110Search for more papers by this authorMarcus E. Raichle MD, Marcus E. Raichle MD Edward Mallinckrodt Institute of Radiology, Department of ...
Tópico(s): Atomic and Subatomic Physics Research
1984 - Wiley | Annals of Neurology
Yi Su, Tyler Blazey, Abraham Z. Snyder, Marcus E. Raichle, Daniel S. Marcus, Beau M. Ances, Randall J. Bateman, Nigel J. Cairns, Patricia Aldea, Lisa Cash, Jon Christensen, Karl A. Friedrichsen, Russ C. Hornbeck, Angela Farrar, Christopher J. Owen, Richard Mayeux, Adam M. Brickman, William E. Klunk, Julie C. Price, Paul M. Thompson, B. Ghetti, Andrew J. Saykin, Reisa A. Sperling, Keith A. Johnson, Peter R. Schofield, Virginia Buckles, John C. Morris, Tammie L.S. Benzinger,
Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders. As positron emission tomography (PET) scanners have limited spatial resolution, measured signals are distorted by partial volume effects. Various techniques have been proposed for correcting partial volume effects, but there is no consensus as to whether these techniques are necessary in amyloid imaging, and, if so, how they should be implemented. We evaluated a two-component partial volume correction technique ...
Tópico(s): Lanthanide and Transition Metal Complexes
2014 - Elsevier BV | NeuroImage
Nico U.F. Dosenbach, Marcus E. Raichle, Evan M. Gordon,
Tópico(s): Neural dynamics and brain function
2025 - Nature Portfolio | Nature reviews. Neuroscience
H. B. Barlow, Colin Blakemore, Miranda Weston-Smith, Rank Prize Funds,
... Blakemore 18. Images of the functioning human brain Marcus Raichle 19. Thinking with a computer Daniel Dennett 20. ...
Tópico(s): Aesthetic Perception and Analysis
1991 - Association of College and Research Libraries | Choice Reviews Online
... pioneering groups worldwide, most notably the group of Marcus Raichle in St Louis, to an ambitious program to ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2008 - Cell Press | Neuron
... the Center for Cognitive Neuroscience at Dartmouth College; Marcus Raichle of the Washington University School of Medicine in ...
Tópico(s): Neuroethics, Human Enhancement, Biomedical Innovations
2006 - Association of College and Research Libraries | Choice Reviews Online
... in St Louis led by William Powers and Marcus Raichle, Hachinski reported that the London, Ontario, group had ...
Tópico(s): Cardiovascular Health and Disease Prevention
1998 - Lippincott Williams & Wilkins | Stroke
Brenda Milner, Larry R. Squire, Eric R. Kandel,
... to cognitive problems. This major advance, pioneered by Marcus Raichle and Michael Posner and by Seiji Ogawa, Ken ...
Tópico(s): Memory Processes and Influences
1998 - Cell Press | Neuron
... current study used the experimental data summarized by Marcus E. Raichle to investigate the neural mechanisms underlying the degradation ... activity, which matched the experimental data summarized by Marcus E. Raichle. Our results further the understanding of the information ...
Tópico(s): Retinal Development and Disorders
2020 - Springer Science+Business Media | Cognitive Neurodynamics
... the default mode network (47–49). In 2001, Marcus Raichle and colleagues described a baseline brain state during ...
Tópico(s): Neural and Behavioral Psychology Studies
2021 - American Psychiatric Association | American Journal of Psychiatry
Tammie L.S. Benzinger, Tyler Blazey, Clifford R. Jack, Robert A. Koeppe, Yi Su, Chengjie Xiong, Marcus E. Raichle, Abraham Z. Snyder, Beau M. Ances, Randall J. Bateman, Nigel J. Cairns, Anne M. Fagan, Alison Goate, Daniel S. Marcus, Paul Aisen, Jon Christensen, Lindsay Ercole, Russ C. Hornbeck, Angela Farrar, Patricia Aldea, Mateusz S. Jasielec, Christopher J. Owen, Xianyun Xie, Richard Mayeux, Adam M. Brickman, Eric McDade, William E. Klunk, Chester A. Mathis, John M. Ringman, Paul M. Thompson, Bernardino Ghetti, Andrew J. Saykin, Reisa A. Sperling, Keith A. Johnson, Stephen Salloway, Stephen Correia, Peter R. Schofield, Colin L. Masters, Christopher C. Rowe, Victor L. Villemagne, Ralph N. Martins, Sébastien Ourselin, Martin N. Rossor, Nick C. Fox, David M. Cash, Michael W. Weiner, David M. Holtzman, Virginia Buckles, Krista L. Moulder, John C. Morris,
Significance Beta-amyloid plaque accumulation, glucose hypometabolism, and neuronal atrophy are hallmarks of Alzheimer’s disease. However, the regional ordering of these biomarkers prior to dementia remains untested. In a cohort with Alzheimer’s disease mutations, we performed an integrated whole-brain analysis of three major imaging techniques: amyloid PET, [ 18 F]fluro-deoxyglucose PET, and structural MRI. We found that most gray-matter structures with amyloid plaques later have hypometabolism followed ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2013 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Anthony P. Fletcher, Norma Alkjærsig, Andrew Davies, M H Lewis, John E. Brooks, William B. Hardin, William Landau, Marcus E. Raichle,
Plasma fibrinogen chromatography is a method for quantification of high molecular weight fibrinogen complexes (HMWFC), native fibrinogen and other fibrinogen derivatives in plasma. Enchanced formation of fibrin, intravascular coagulation, thrombus formation, etc., are reflected by elevation of plasma HMWFC, and the method distinguishes between subjects with normal and pathological rates of fibrin formation. Serial standard blood coagulation assays, including plasma fibrinogen chromatography, and ...
Tópico(s): Neurological Disorders and Treatments
1976 - Lippincott Williams & Wilkins | Stroke
Anthony P. Fletcher, Norma Alkjærsig, M H Lewis, V. Tulevski, Andrew Davies, John E. Brooks, William B. Hardin, William M. Landau, Marcus E. Raichle,
Thirty-one patients with acute cerebral infarction were treated with the thrombolytic agent urokinase for either a single or a double infusion period, each of ten hours. The effects of urokinase therapy administered at dosage rates of 1,200, 1,500 or 1,700 CTA urokinase units per pound of body weight per hour were followed by serial blood coagulation and other biochemical studies. In the dosage used, urokinase produced a prompt sustained increase, 20-fold to 40-fold, of plasma thrombolytic activity ...
Tópico(s): Alzheimer's disease research and treatments
1976 - Lippincott Williams & Wilkins | Stroke
• To test the hypothesis that regional cerebral blood flow (rCBF) is normally regulated by regional metabolic activity, rCBF and the regional cerebral metabolic rate for oxygen (rCMRO 2 ) were compared in selected human subjects. In normal subjects and patients with chronic, stable diseases of brain, rCBF correlated well with rCMRO 2 . In one individual with mild dementia, rCBF and rCMRO 2 were measured before and during exercise of the hand and forearm contralateral to the hemisphere studied. Appropriate ...
Tópico(s): S100 Proteins and Annexins
1976 - American Medical Association | Archives of Neurology
Marcus E. Raichle, Boyd K. Hartman, John O. Eichling, L. G. Sharpe,
Anatomical studies employing the immunofluorescence localization of dopamine-beta-hydroxylase [= dopamine beta-monooxygenase; 3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase (beta-hydroxylating); EC 1.14.17.1] have demonstrated in brain central noradrenergic nerve fibers on small intraparenchymal blood vessels, including capillaries. This system is distinct from the peripheral noradrenergic system inervating the large extraparenchymal blood vessels. From these anatomical findings evolved ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
1975 - National Academy of Sciences | Proceedings of the National Academy of Sciences
John O. Eichling, Marcus E. Raichle, Robert L. Grubb, Kenneth B. Larson, M. M. Ter-Pogossian,
A method for the in vivo determination of cerebral blood volume was tested in 15 adult rhesus monkeys. The technique utilized external residue detection and required the serial measurement of two mean transit times, namely, that of an intravascular tracer, C15O-hemoglobin, and that of a diffusible tracer, H215O. In computing the mean transit time for the intravascular tracer, the conventional Hamilton extrapolation of the downslope of the recording obtained for the washout of the tracer from the ...
Tópico(s): Advanced MRI Techniques and Applications
1975 - Lippincott Williams & Wilkins | Circulation Research
Robert L. Grubb, Marcus E. Raichle, Michael E. Phelps, Robert A. Ratcheson,
✓ The relationship of cerebral blood volume (CBV) to cerebral perfusion pressure (CPP), cerebral blood flow (CBF), and the cerebral metabolic rate for oxygen (CMRO 2 ) was examined in rhesus monkeys. In vivo tracer methods employing radioactive oxygen-15 were used to measure CBV, CBF, and CMRO 2 . Cerebral perfusion pressure was decreased by raising the intracranial pressure (ICP) by infusion of artificial cerebrospinal fluid (CSF) into the cisterna magna. The production of progressive intracranial hypertension ...
Tópico(s): MRI in cancer diagnosis
1975 - American Association of Neurological Surgeons | Journal of neurosurgery
Milton J. Hernández-Pérez, Marcus E. Raichle, H. L. Stone,
The effect of chronic, unilateral superior cervical ganglionectomy on cerebral blood flow and blood flow autoregulation to changes in perfusion pressure was examined in seven phencyclidine anesthetized monkeys. Ten to 14 days prior to the experiments Doppler ultrasonic flow transducers were placed on both carotid arteries after ligation of the external carotid branches and removal of one superior cervical ganglion. Autoregulation was tested by exsanguination and metaraminol infusion with the monkeys ...
Tópico(s): Neurosurgical Procedures and Complications
1975 - Lippincott Williams & Wilkins | Stroke
Robert L. Grubb, MILTON J. HERNANDEZ-PERIZ, Marcus E. Raichle, Michael E. Phelps,
The effects of an iodinated contrast agent, Renografin-76® upon cerebral autoregulation was studied in rhesus monkeys. This was done by measuring the effects of an intravenous injection of Renografin-76 upon: (1) the response of baseline CBF as measured by the washout of a carotid bolus of H 2 15 O during and after the injection of Renografin-76, (2) the response of CBF monitored continuously by a Doppler flow probe technique to changes in the mean arterial blood pressure (MABP) before and after an ...
Tópico(s): Acute Ischemic Stroke Management
1974 - Lippincott Williams & Wilkins | Stroke
John O. Eichling, Marcus E. Raichle, Robert L. Grubb, Michel M. Ter‐Pogossian,
The extraction of 15 O-labeled water by the brain during a single capillary transit was studied in vivo in 20 adult rhesus monkeys by external detection of the time course of the tracer subsequent to the internal carotid injection of 0.2 ml of whole blood labeled with H 2 15 O. The data showed that labeled water does not freely equilibrate with the exchangeable water in the brain when the mean cerebral blood flow exceeds 30 ml/100 g min -1 . At the normal cerebral blood flow in the rhesus monkey (∼50 ...
Tópico(s): Chemical Reactions and Isotopes
1974 - Lippincott Williams & Wilkins | Circulation Research
Robert L. Grubb, Marcus E. Raichle, John O. Eichling, Michel M. Ter‐Pogossian,
The relationships between cerebral blood volume (CBV), cerebral blood flow (CBF), and the cerebral vascular mean transit time (t v ) during acute changes in the Pa CO 2 over a range of 15 to 76 torr were investigated in vivo in rhesus monkeys by serially determining the mean transit time of a vascular tracer, 15 O-labeled carboxyhemoglobin, and the mean transit time of a diffusible tracer, 15 O-labeled water. Over this range of Pa CO 2 , a significant linear relationship of CBV = 0.041 Pa CO 2 + 2.0 was found. ...
Tópico(s): Cerebrospinal fluid and hydrocephalus
1974 - Lippincott Williams & Wilkins | Stroke