... and (CH3)2O ⃛ DCl complexes Marek J. Wójcik, Marek J. Wójcik The James Franck Institute, The University ... for more papers by this author Marek J. Wójcik, Marek J. Wójcik The James Franck Institute, The University of Chicago, ...
Tópico(s): Spectroscopy and Laser Applications
1986 - Wiley | International Journal of Quantum Chemistry
Mateusz Z. Brela, Marek J. Wójcik, Marek Boczar, Łukasz J. Witek, Mitsuru Yasuda, Yukihiro Ozaki,
We studied proton dynamics of a hydrogen bonds of the crystalline l-ascorbic acid. Our approach was based on the Car-Parrinello molecular dynamics. The focal point of our study was simulation of the infrared spectra of l-ascorbic acid associated with the O-H stretching modes that are very sensitive to the strength of hydrogen bonding. In the l-ascorbic acid there are four kinds of hydrogen bonds. We calculated their spectra by using anharmonic approximation and the time course of the dipole moment ...
Tópico(s): Free Radicals and Antioxidants
2015 - American Chemical Society | The Journal of Physical Chemistry B
Mateusz Z. Brela, Marek J. Wójcik, Marek Boczar, Rauzah Hashim,
The nature of strong intermolecular hydrogen bonding in oxalic acid dihydrate in the crystal phase was examined by infrared spectroscopy and Car–Parrinello molecular dynamics simulation. We studied region of infrared spectra associated with the O—H modes. The spectra were calculated using harmonic approximation with crystal field and time course of the dipole moment as obtained from Car–Parrinello simulation with quantization of the O—H motion, and isotopic substitution. We obtained good agreement ...
Tópico(s): Solid-state spectroscopy and crystallography
2013 - Elsevier BV | Chemical Physics Letters
Marek J. Wójcik, Marek Boczar, T.A. Ford,
The interaction energies, structures and vibrational band wavenumbers of the binary complexes formed between water and carbon oxysulfide, and water and nitrous oxide, have been predicted by means of ab initio molecular orbital theory. The results are discussed in the light of high resolution gas phase infrared and microwave, and matrix isolation infrared spectroscopic studies, and of previous theoretical calculations on similar and containing carbon dioxide complexes.
Tópico(s): Molecular Spectroscopy and Structure
2001 - Elsevier BV | Chemical Physics Letters
Radoslaw Wojcik, Marek R. Baranowski, Łukasz Markiewicz, Dorota Kubacka, Marcelina Bednarczyk, Natalia Baran, Anna Wojtczak, Pawel J. Sikorski, Joanna Zuberek, Joanna Kowalska, Jacek Jemielity,
Dinucleotide analogs of the messenger RNA cap (m7GpppN) are useful research tools and have potential applications as translational inhibitors or reagents for modification of in vitro transcribed mRNAs. It has been previously reported that replacing the methyl group at the N7-position with benzyl (Bn) produces a dinucleotide cap with superior properties. Here, we followed up on this finding by synthesizing 17 novel Bn7GpppG analogs and determining their structure-activity relationship regarding translation ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Abhishek Kumar Patel, Dariusz Siemiaszko, Julita Dworecka-Wójcik, Marek Polański,
Despite many years having passed since it was discovered, FeTi alloys remain one of the most important low-temperature hydrogen storage alloys due to its high capacity, characteristics and low price. However, the main technological issue is its initial activation, which is usually conducted at relatively high temperature and pressure. This paper is the first to show that the complicated process can be replaced by intense movement of the powder or even chunks of alloy under hydrogen pressure without ...
Tópico(s): Ammonia Synthesis and Nitrogen Reduction
2021 - Elsevier BV | International Journal of Hydrogen Energy
Justyna Hajtuch, Nadhim Kamil Hante, Ewelina Tomczyk, Michał Wójcik, Marek Radomski, María José Santos-Martínez, Iwona Inkielewicz‐Stępniak,
We studied the effects of silver nanoparticles (AgNPs) on human blood platelet function. We hypothesized that AgNPs, a known antimicrobial agent, can be used as blood-compatible, "ideal material'' in medical devices or as a drug delivery system. Therefore, the aim of the current study was to investigate if functionalized AgNPs affect platelet function and platelets as well as endothelial cell viability in vitro.AgNPs, functionalized with reduced glutathione (GSH), polyethylene glycol (PEG) and lipoic ...
Tópico(s): Polymer Surface Interaction Studies
2019 - Dove Medical Press | International Journal of Nanomedicine
Magdalena Kumor, Magdalena Lipczyńska, Elżbieta Katarzyna Biernacka, Anna Klisiewicz, Anna Wójcik, Marek Konka, Katarzyna Kożuch, Piotr Szymański, Piotr Hoffmań,
Tópico(s): Cardiac Valve Diseases and Treatments
2018 - Elsevier BV | Journal of Cardiology
Piotr Wójcik, Marek Jasiówka, E. Strycharz, Monika Sobol, Diana Hodorowicz‐Zaniewska, Piotr Skotnicki, Tomasz Byrski, Paweł Blecharz, Elżbieta Marczyk, Ida Cedrych, Jerzy Jakubowicz, Jan Lubiński, Victoria Sopik, Steven A. Narod, Piotr Pierzchalski,
Mutations in the BRCA1, BRCA2 and PALB2 genes are well-established risk factors for the development of breast and/or ovarian cancer. The frequency and spectrum of mutations in these genes has not yet been examined in the population of Southern Poland.We examined the entire coding sequences of the BRCA1 and BRCA2 genes and genotyped a recurrent mutation of the PALB2 gene (c.509_510delGA) in 121 women with familial and/or early-onset breast or ovarian cancer from Southern Poland.A BRCA1 mutation was ...
Tópico(s): Genomic variations and chromosomal abnormalities
2016 - BioMed Central | Hereditary Cancer in Clinical Practice
Leanne de Kock, Talia Boshari, Fabio Martinelli, Elżbieta Wójcik, Marek Niedziela, William D. Foulkes,
In Brief Both germline and somatic mutations in the microRNA processing gene DICER1 can occur in adult-onset cervical embryonal rhabdomyosarcoma.
Tópico(s): Tumors and Oncological Cases
2015 - Lippincott Williams & Wilkins | Journal of Lower Genital Tract Disease
Toshiyuki Ohtani, Sylvain Bouix, Amanda E. Lyall, Taiga Hosokawa, Yukiko Saito, Eric D. Melonakos, Carl‐Fredrik Westin, Larry J. Seidman, Jill M. Goldstein, Raquelle I. Mesholam‐Gately, Tracey L. Petryshen, Joanne Wojcik, Marek Kubicki,
The medial orbitofrontal cortex (mOFC) and rostral part of anterior cingulate cortex (rACC) have been suggested to be involved in the neural network of salience and emotional processing, and associated with specific clinical symptoms in schizophrenia. Considering the schizophrenia dysconnectivity hypothesis, the connectivity abnormalities between mOFC and rACC might be associated with clinical characteristics in first episode schizophrenia patients (FESZ). After parcellating mOFC into the anterior ...
Tópico(s): Schizophrenia research and treatment
2015 - Elsevier BV | Cortex
Dominick J. Angiolillo, Robert C. Welsh, Dietmar Trenk, Franz‐Josef Neumann, Pamela B. Conley, Matthew W. McClure, Gill Stephens, Janusz Kochman, Lisa K. Jennings, Paul A. Gurbel, Jarosław Wójcik, Marek Dąbrowski, Jorge F. Saucedo, Juergen Stumpf, Michael Buerke, Samuel Broderick, Robert A. Harrington, Sunil V. Rao,
Elinogrel is the only selective, competitive and reversible platelet P2Y(12) inhibitor available in both intravenous (IV) and oral formulations.This substudy of the Intravenous and Oral Administration of Elinogrel to Evaluate Tolerability and Efficacy in Nonurgent Percutaneous Coronary Intervention patients (INNOVATE-PCI) trial evaluated the pharmacokinetic and pharmacodynamic effects of two dosing regimens of IV followed by oral elinogrel (120 mg IV plus 100 mg oral twice daily; 120 mg IV plus 150 ...
Tópico(s): Inflammatory mediators and NSAID effects
2012 - Lippincott Williams & Wilkins | Circulation Cardiovascular Interventions
J Lamprecht, Cezary Wójcik, Marek Jakóbisiak, Micheal Stoehr, Dieter Schrorter, Neidhard Paweletz,
We examined the effects of lovastatin, a common anti‐atherosclerotic drug and a blocker of the cell cycle, on the process of mitosis. It is known that lovastatin induces an arrest or a retardation of the cell cycle in many cell types not only at the G 1 phase, but also at the G 2 /M transition. After 24–48h incubation of epithelial PtK 2 , T24, HeLa cells and fibroblastic L929 cells in the presence of 1.0–60.0μm lovastatin, diverse mitotic perturbations have been observed. The most noteworthy phenomena ...
Tópico(s): Protein Structure and Dynamics
1999 - Wiley | Cell Biology International
Gabriela Mochol, Daniel K. Wójcik, Marek Wypych, Andrzej Wróbel, Wioletta J. Waleszczyk,
Visually responding neurons in the superficial, retinorecipient layers of the cat superior colliculus receive input from two primarily parallel information processing channels, Y and W, which is reflected in their velocity response profiles. We quantified the time-dependent variability of responses of these neurons to stimuli moving with different velocities by Fano factor (FF) calculated in discrete time windows. The FF for cells responding to low-velocity stimuli, thus receiving W inputs, increased ...
Tópico(s): Visual perception and processing mechanisms
2010 - Society for Neuroscience | Journal of Neuroscience
Magdalena Paczkowska, Emilia Szymańska, Katarzyna Winnicka, Dominik Szwajgier, Ewa Baranowska‐Wójcik, Marek Ruchała, Marek Šimon, Judyta Cielecka‐Piontek,
Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of resveratrol and to assure its high content in plant material, an ultrasound-assisted extraction method was applied. The addition of cyclodextrin was found to increase the extraction efficiency of resveratrol ( ...
Tópico(s): Advanced Drug Delivery Systems
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Mateusz Z. Brela, M. Wójcik, Marek Boczar, Erika Onishi, Harumi Sato, Takahito Nakajima, Yukihiro Ozaki,
Abstract Proton dynamics of hydrogen bonds (HBs) in the α and γ form of Nylon 6 were investigated by Born–Oppenheimer molecular dynamics (BOMD). Our results show differences in the dynamic effects of interchain HB interactions between the α form and the γ form of Nylon 6. Analysis of the time course of the geometrical parameters of HBs along the BOMD simulations has shown that HBs are dynamically favored in the γ form of Nylon. The quantization of the NH stretching mode enables a detailed discussion ...
Tópico(s): Polymer Nanocomposites and Properties
2018 - Wiley | International Journal of Quantum Chemistry
Paweł Płudowski, Beata Kos‐Kudła, Mieczysław Walczak, Andrzej Fal, Dorota Zozulińska‐Ziółkiewicz, Piotr Sieroszewski, Jarosław Peregud‐Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewiński, Robert Spaczyński, Mirosław Wielgoś, Jarosław Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchała, Arkadiusz Zygmunt, Mieczysław Szalecki, Artur Bossowski, Justyna Czech‐Kowalska, Marek Wójcik, Beata Pyrżak, Michał A. Żmijewski, Paweł Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spyridon Ν. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski,
All epidemiological studies suggest that vitamin D deficiency is prevalent among the Polish general population. Since vitamin D deficiency was shown to be among the risk factors for many diseases and for all-cause mortality, concern about this problem led us to update the previous Polish recommendations.
Tópico(s): Healthcare cost, quality, practices
2023 - Multidisciplinary Digital Publishing Institute | Nutrients
Agnieszka Janiec, Paulina Halat-Wolska, Łukasz Obrycki, Elżbieta Ciara, Marek Wójcik, Paweł Płudowski, Aldona Wierzbicka, Ewa Kowalska, Janusz Książyk, Zbigniew Kułaga, Ewa Pronicka, Mieczysław Litwin,
Infantile hypercalcaemia (IH) is a vitamin D3 metabolism disorder. The molecular basis for IH is biallelic mutations in the CYP24A1 or SLC34A1 gene. These changes lead to catabolism disorders (CYP24A1 mutations) or excessive generation of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] (SLC34A1 mutations). The incidence rate of IH in children and the risk level for developing end-stage renal disease (ESRD) are still unknown. The aim of this study was to analyse the long-term outcome of adolescents and young adults ...
Tópico(s): Bone Metabolism and Diseases
2020 - Oxford University Press | Nephrology Dialysis Transplantation
Kamil Piska, Paulina Koczurkiewicz, Dawid Wnuk, Elżbieta Karnas, Adam Bucki, Katarzyna Wójcik‐Pszczoła, Marek Jamrozik, Marta Michalik, Marcin Kołaczkowski, Elżbieta Pękala,
One of the causes of therapeutic failure of chemotherapy is cancer cell resistance. In the case of anthracyclines, many resistance mechanisms have been described. One of them assumes the role of carbonyl reductase 1 (CBR1), a cytosolic enzyme that is responsible for the biotransformation process of anthracyclines to less active, undesirable metabolites. Therefore, CBR1 inhibitors are considered for use as a chemosensitizing agents. In the present study, piperlongumine (PL), a Piper longum L. alkaloid ...
Tópico(s): Synthesis and Biological Evaluation
2019 - Elsevier BV | Chemico-Biological Interactions
P. Caban, Dominika Teklińska, Paweł Piotr Michałowski, J. Gaca, Marek Wójcik, Justyna Grzonka, P. Ciepielewski, M. Możdżonek, Jacek Baranowski,
Boron nitride films were grown on 2-inch sapphire substrates using the MOCVD technique. The growth was performed using a pulsed source injection mode with triethylborane (TEB) and ammonia (NH3) with a high V/III ratio, which corresponds to the self-terminated growth mode. Two different carrier gases, H2 and Ar, were used to investigate their influence on the growth mechanism, while all the other growth parameters were kept the same. The BN films thus obtained were examined using XRR, SIMS, Raman spectroscopy, ...
Tópico(s): Boron and Carbon Nanomaterials Research
2018 - Elsevier BV | Journal of Crystal Growth
Ewa Pronicka, Elżbieta Ciara, Paulina Halat, Agnieszka Janiec, Marek Wójcik, E Rowińska, Dariusz Rokicki, Paweł Płudowski, Ewa Wojciechowska, Aldona Wierzbicka, Janusz Książyk, Agnieszka Jacoszek, Martin Konrad, Karl P. Schlingmann, Mieczysław Litwin,
Idiopathic infantile hypercalcemia (IIH) is a mineral metabolism disorder characterized by severe hypercalcemia, failure to thrive, vomiting, dehydration, and nephrocalcinosis. The periodical increase in incidence of IIH, which occurred in the twentieth century in the United Kingdom, Poland, and West Germany, turned out to be a side effect of rickets over-prophylaxis. It was recently discovered that the condition is linked to two genes, CYP24A1 and SLC34A1. The aim of the study was to search for ...
Tópico(s): Adrenal Hormones and Disorders
2017 - Springer Nature | Journal of Applied Genetics
Harjit Pal Bhattoa, Jerzy Konstantynowicz, Natalia Łaszcz, Marek Wójcik, Paweł Płudowski,
Tópico(s): Nutrition and Health in Aging
2016 - Springer Science+Business Media | Reviews in Endocrine and Metabolic Disorders
Louise Moody, Janet Saunders, Marjan Leber, Marzena Wójcik‐Augustyniak, Marek Szajczyk, Nataša Rebernik,
Background: The European Disability Strategy (2010–2020) seeks to significantly raise the proportion of people with disabilities working in the open labour market. The ERGO WORK project is a collaboration of academic and industrial partners in six European countries, focused on understanding and tackling barriers to workplace inclusion for workers with disabilities.Methods: This study sought to explore the perceptions and needs of stakeholders in terms of workplace adaptation to the needs of employees ...
Tópico(s): Environmental Sustainability in Business
2016 - Informa | Disability and Rehabilitation
Agnieszka Wójcik-Mazur, Marek Szajt,
In this paper we analyse the determinants of liquidity risk of commercial banks by comparing dependencies in two dichotomous groups, including banks operating in the countries of the so-called Old European Union (Austria, Belgium, Germany, Denmark, Spain, Finland, France, the UK, Greece, Ireland, Italy, Portugal) and the countries of the so-called New European Union (Bulgaria, the Czech Republic, Hungary, Poland, Romania, Slovenia, Slovakia). On the basis of two indicators of liquidity risk, we estimate ...
Tópico(s): Credit Risk and Financial Regulations
2015 - | Argumenta Oeconomica
Marek J. Wójcik, Jacek Kwiendacz, Marek Boczar, Łukasz Boda, Yukihiro Ozaki,
Theoretical simulation of the bandshape and fine structure of the N–H(D) stretching band is presented for imidazole and its deuterated derivative taking into account adiabatic coupling between the high-frequency N–H(D) stretching and the low-frequency N⋯N stretching vibrations, anharmonicity of the potentials for the low-frequency vibrations in the ground and excited state of the N–H(D) stretching mode, Fermi resonance between the N–H(D) stretching and the first overtone of the N–H(D) bending vibrations, ...
Tópico(s): Photochemistry and Electron Transfer Studies
2010 - Elsevier BV | Chemical Physics
Marek J. Wójcik, Łukasz Boda, Marek Boczar,
Ab initio CIS/6-311++G(d,p) calculations of geometry and vibrational frequencies have been carried out in the à state of tropolone. The grids of potential energy surfaces along the coordinates of high frequency tunneling vibration and the low-frequency coupled vibration have been calculated. Two-dimensional model potentials, formed from symmetric mode coupling potential and squeezed double well potential, have been fitted to the calculated potential energy surfaces and used to analyze proton dynamics. ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2009 - American Institute of Physics | The Journal of Chemical Physics
Marek Wójcik, Jan Lindgren, Jörgen Tegenfeldt,
A simple intra- and inter-molecular potential for water molecules engaged in hydrogen bonding has been used in a one-dimensional approximation for a theoretical interpretation of the experimental correlation vOH/vOD versus vOH in solid hydrates. The variation in the equilibrium OH(D) distance has also been considered.
Tópico(s): Spacecraft and Cryogenic Technologies
1983 - Elsevier BV | Chemical Physics Letters
Mateusz Z. Brela, Marek J. Wójcik, Łukasz J. Witek, Marek Boczar, Ewa Wrona, Rauzah Hashim, Yukihiro Ozaki,
In this study, the proton dynamics of hydrogen bonds for two forms of crystalline aspirin was investigated by the Born-Oppenheimer molecular dynamics (BOMD) method. Analysis of the geometrical parameters of hydrogen bonds using BOMD reveals significant differences in hydrogen bonding between the two crystalline forms of aspirin, Form I and Form II. Analysis of the trajectory for Form I shows spontaneous proton transfer in cyclic dimers, which is absent in Form II. Quantization of the O-H stretching ...
Tópico(s): Analytical Chemistry and Chromatography
2016 - American Chemical Society | The Journal of Physical Chemistry B
Marek J. Wójcik, Krzysztof Szczeponek, Marek Boczar,
Ab initio B3LYP/6-311++G** calculations have been carried out for the benzoic acid dimer for the stable and saddle point structures. The energy barrier for the proton tunneling amounts to 6.5 kcal/mol. The normal mode frequencies have been computed including modes coupled to the proton tunneling mode. Two-dimensional model potentials, formed from symmetric mode coupling potential and squeezed double well potential, have been fitted to the calculated energy barrier, geometries and frequencies, and ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2003 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Willem Siebrand, Marek Z. Zgierski, Francesco Zerbetto, Marek J. Wójcik, Marek Boczar, Tapas Chakraborty, William G. Kofron, Edward C. Lim,
Fluorescence excitation spectra covering the origin–band region of the two partially methyl-deuterated toluenes (α-deuterotoluene, C6H5CH2D and α-dideuterotoluene, C6H5CHD2) are reported. The spectra, observed in a cold supersonic beam, show transitions between low methyl–rotor levels, and are analyzed in terms of vibrationally adiabatic torsional potentials with two-, four-, and sixfold periodicity. To interpret the resulting potential parameters, ab initio vibrational force field calculations are ...
Tópico(s): Quantum, superfluid, helium dynamics
1997 - American Institute of Physics | The Journal of Chemical Physics