Bariş Gencer, Marco Bonomi, Maria Pia Adorni, Cesare R. Sirtori, François Mach, Massimiliano Ruscica,
Abstract The cardiovascular (CV) benefit and safety of treating low testosterone conditions is a matter of debate. Although testosterone deficiency has been linked to a rise in major adverse CV events, most of the studies on testosterone replacement therapy were not designed to assess CV risk and thus excluded men with advanced heart failure or recent history of myocardial infarction or stroke. Besides considering observational, interventional and prospective studies, this review article evaluates ...
Tópico(s): Pharmacology and Obesity Treatment
2021 - Springer Science+Business Media | Reviews in Endocrine and Metabolic Disorders
Jeness Campodonico, Flavia Nicoli, Irene Motta, Margherita Migone De Amicis, Alice Bonomi, Maria Domenica Cappellini, Piergiuseppe Agostoni,
In heart failure (HF) iron deficiency (ID) is frequently observed and represents a major mortality risk factor. Purpose of this study was to evaluate the correlation between mortality and ID in a cohort of 661 consecutive patients hospitalized for HF worsening.Patients were grouped: (i)according to presence(+)/absence(-) of anaemia (A) and ID defined following World Health Organization (WHO) and European Society of Cardiology (ESC)-American College of Cardiology/American Heart Association/HF society of ...
Tópico(s): Dialysis and Renal Disease Management
2021 - Oxford University Press | European Journal of Preventive Cardiology
Mauro Marengo, Aristodemo Carpen, Francesco Bonomi, Maria Cristina Casiraghi, Erika Meroni, L. Quaglia, Stefania Iametti, Maria Ambrogina Pagani, Alessandra Marti,
Pulse flour may be used to improve nutritional traits of gluten and gluten‐free formulations in traditional food such as bread or pasta. However, owing to some intrinsic nutritional, textural, and sensory properties, the use of pulses as ingredients for production of enriched food remains limited. In this study, we investigated the modification in macromolecules and micronutrients in industrial‐scale flour from partially sprouted chickpeas to define its possible use as an ingredient in cereal‐based ...
Tópico(s): Phytoestrogen effects and research
2016 - Wiley | Cereal Chemistry
Alessandra Marti, Mauro Marengo, Francesco Bonomi, Maria Cristina Casiraghi, L. Franzetti, Maria Ambrogina Pagani, Stefania Iametti,
The effects of fermentation of teff flour by a mixture of lactic acid bacteria and yeasts present in a gluten-free sourdough have been considered. Fermentation had a major impact on the physicochemical properties of teff starch and on its pasting behavior, and a somewhat more limited impact on teff proteins, leaving essentially intact protein components of possible relevance for formation of a protein network. Either fermented or non-fermented teff were added to a 25% level to a commercial corn- ...
Tópico(s): Phytase and its Applications
2016 - Elsevier BV | LWT
Donata Paternicò, Marta Manes, Enrico Premi, Maura Cosseddu, Stefano Gazzina, Antonella Alberici, Silvana Archetti, Elisa Bonomi, Maria Sofia Cotelli, Maria Cotelli, Marinella Turla, Anna Micheli, Roberto Gasparotti, Alessandro Padovani, Barbara Borroni,
Abstract Variations within genes associated with dyslexia result in a language network vulnerability, and in patients with Frontotemporal Dementia (FTD), language disturbances represent a disease core feature. Here we explored whether variations within three related-dyslexia genes, namely KIAA0319 , DCDC2 , and CNTNAP , might affect cortical thickness measures in FTD patients. 112 FTD patients underwent clinical and neuropsychological examination, genetic analyses and brain Magnetic Resonance Imaging (MRI). ...
Tópico(s): Epilepsy research and treatment
2016 - Nature Portfolio | Scientific Reports
Angelica Miccolis, Michele Galluccio, Chiara Nitride, Teresa Anna Giancaspero, Pasquale Ferranti, Stefania Iametti, Cesare Indiveri, Francesco Bonomi, Maria Barile,
Tópico(s): Mitochondrial Function and Pathology
2014 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Alberto Barbiroli, Francesco Bonomi, Maria Cristina Casiraghi, Stefania Iametti, Maria Ambrogina Pagani, Alessandra Marti,
Structural changes of starch and proteins in rice pasta were investigated as a function of raw-materials and pasta-making conditions, and their impact on cooking behaviour and glycaemic index was assessed. Rice pasta was prepared from untreated or parboiled rice flour by conventional extrusion or by extrusion-cooking. Starch structure was studied by assessing starch accessibility to specific enzymes (α-amylase and pullulanase), and by evaluating the molecular properties of fragments from enzymatic ...
Tópico(s): Proteins in Food Systems
2012 - Elsevier BV | Carbohydrate Polymers
Hernán R. Bonomi, María Inés Marchesini, Sebastián Klinke, Juan E. Ugalde, Vanesa Zylberman, Rodolfo A. Ugalde, Diego J. Comerci, Fernando A. Goldbaum,
Brucellosis is a worldwide zoonosis that affects livestock and humans and is caused by closely related Brucella spp., which are adapted to intracellular life within cells of a large variety of mammals. Brucella can be considered a furtive pathogen that infects professional and non-professional phagocytes. In these cells Brucella survives in a replicative niche, which is characterized for having a very low oxygen tension and being deprived from nutrients such as amino acids and vitamins. Among these ...
Tópico(s): Bacteriophages and microbial interactions
2010 - Public Library of Science | PLoS ONE
Verónica A. Vega, Ana Cecilia Anzulovich, Silvia M. Varas, Mirtha Ruth Bonomi, María S. Giménez, Liliana Oliveros,
We studied the effect of dietary vitamin A deprivation on lipid composition and mRNA expression of regulatory enzymes involved in rat heart energetic lipid metabolism and its relation to the expression of peroxisome proliferator-activated receptor (PPAR) and retinoid X receptor (RXR) genes. Male Wistar 21-d-old rats were fed for 3 mo with a vitamin A–free diet (vitamin A–deficient group) and the same diet plus 8 mg of retinol palmitate per kilogram of diet (control group). One group of deficient animals ...
Tópico(s): Adipose Tissue and Metabolism
2009 - Elsevier BV | Nutrition
Stefania Iametti, Francesco Bonomi, Maria Ambrogina Pagani, M. Zardi, Cristina Cecchini, M. G. D’Egidio,
The time course of compositional changes in the polysaccharide and protein fractions, and of changes in protein structural properties, was investigated in grains of two Italian durum wheat cultivars, Ofanto and Duilio, and the pattern of changes was found to be specific to each cultivar. The fructo-oligosaccharide content in ripening kernels was different between cultivars, as was the pattern of starch accumulation. Evaluation of gluten proteins by Western-blotting using broad-specificity anti-gliadin ...
Tópico(s): Phytase and its Applications
2006 - American Chemical Society | Journal of Agricultural and Food Chemistry
Leandro Cerchietti, Alfredo Navigante, Maribel A. Lutteral, M. Castro, Ricardo Kirchuk, Marcelo Bonomi, María E. Cabalar, Berta Roth, Graciela Negretti, Beatriz Sheinker, Patricia Uchima,
Tópico(s): Salivary Gland Disorders and Functions
2006 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
L. Mazzarella, Giovanna Bonomi, Maria C. Lubrano, Antonello Merlino, Antonio Riccio, Alessandro Vergara, Luigi Vitagliano, Cinzia Verde, Guido di Prisco,
The cathodic hemoglobin component of the Antarctic fish Trematomus newnesi (HbCTn) is a Root-effect protein. The interpretation of its functional properties in relation to its sequence is puzzling. Indeed, HbCTn sequence is characterized by an extremely low histidyl content, and in particular by the lack of His146beta and His69beta, which are believed to be important in Bohr and Root effects, respectively. Furthermore, previous analyses suggested that the local environment of Asp95alpha, Asp99beta, ...
Tópico(s): Erythrocyte Function and Pathophysiology
2005 - Wiley | Proteins Structure Function and Bioinformatics
Marco Bonomi, Maria Carla Proverbio, Giovanna Weber, G Chiumello, Paolo Beck-Peccoz, Luca Persani,
Inheritable isolated central hypothyroidism (ICH) due to mutations of TSHβ gene has been reported in few patients. For this reason the diagnostic criteria are vague. The disorder is usually characterized by undetectable TSH levels, although low/normal serum TSH, depending on TSH measurement methods, has been documented in some patients. Here we report an Egyptian girl with ICH due to a novel nonsense mutation of the TSHβ gene (Q49X). She was referred at 75 days of age for severe clinical signs of ...
Tópico(s): Regulation of Appetite and Obesity
2001 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Marco Bonomi, Maria Carla Proverbio, Giovanna Weber, G Chiumello, Paolo Beck‐Peccoz, Luca Persani,
Inheritable isolated central hypothyroidism (ICH) due to mutations of TSHβ gene has been reported in few patients. For this reason the diagnostic criteria are vague. The disorder is usually characterized by undetectable TSH levels, although low/normal serum TSH, depending on TSH measurement methods, has been documented in some patients. Here we report an Egyptian girl with ICH due to a novel nonsense mutation of the TSHβ gene (Q49X). She was referred at 75 days of age for severe clinical signs of ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2001 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
David Cella, Lesbia Hernández, Amy E. Bonomi, María Eugenia Jiménez Corona, Maria Vaquero, Gail Shiomoto, Luis Báez,
There is a need in the United States for culture-equivalent assessment of health-related quality of life, particularly among people who speak different languages and among those with low literacy skills. This report summarizes the adaptation of the Functional Assessment of Cancer Therapy (FACT) Scales for use with Spanish-speaking cancer patients, including those with low literacy.The Spanish language version of the general Functional Assessment of Cancer Therapy scale plus five disease-specific ...
Tópico(s): Global Cancer Incidence and Screening
1998 - Lippincott Williams & Wilkins | Medical Care
Francesco Bonomi, Maria Luisa Ganadu, Giuseppe Lubinu, Silvia Pagani,
Incubation of native, reduced Clostridium pasteurianum ferredoxin with different metals gave a range of modifications in the electronic and EPR spectrum of the protein, or made the signals disappear. The reduced protein, isolated after incubation with different metals under identical conditions (50 μM protein, 1 mM metal, 1 h incubation) was found to contain amounts of foreign metals increasing with their thiophylicity, i.e. Cd 2+ ≫ Zn 2+ > Co 2+ . Little, if any, incorporation was observed for Ni 2+ , Cu ...
Tópico(s): Electrochemical Analysis and Applications
1994 - Wiley | European Journal of Biochemistry
Mauro Marengo, Hannah Akoto, M. Zanoletti, Aristodemo Carpen, Simona Buratti, S. Benedetti, Alberto Barbiroli, Paa‐Nii T. Johnson, Esther Sakyi‐Dawson, Firibu Kwesi Saalia, Francesco Bonomi, Maria Ambrogina Pagani, John Manful, Stefania Iametti,
Snacks were produced by extruding blends of partially-defatted soybean flour with flours from milled or parboiled African-grown rice. The interplay between composition and processing in producing snacks with a satisfactory sensory profile was addressed by e-sensing, and by molecular and rheological approaches. Soybean proteins play a main role in defining the properties of the protein network in the products. At the same content in soybean flour, use of parboiled rice flour increases the snack's ...
Tópico(s): Sensory Analysis and Statistical Methods
2016 - Multidisciplinary Digital Publishing Institute | Foods
Giovanni Luca Ceresoli, Maria Bonomi, Maria Grazia Sauta,
Tópico(s): Management of metastatic bone disease
2016 - Taylor & Francis | Expert Review of Anticancer Therapy
Giulia Grizzi, Massimiliano Salati, Maria Bonomi, Margherita Ratti, Lauren Holladay, Maria Caterina De Grandis, Daniele Spada, Gian Luca Baiocchi, Michele Ghidini,
Gastric cancer (GC) is still one of the most aggressive cancers with a few targetable alterations and a dismal prognosis. A liquid biopsy allows for identifying and analyzing the DNA released from tumor cells into the bloodstream. Compared to tissue-based biopsy, liquid biopsy is less invasive, requires fewer samples, and can be repeated over time in order to longitudinally monitor tumor burden and molecular changes. Circulating tumor DNA (ctDNA) has been recognized to have a prognostic role in all ...
Tópico(s): Lung Cancer Treatments and Mutations
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
José Antonio Sainz‐Bueno, Maria Bonomi, Carmen Suárez-Serrano, Esther M. Medrano-Sánchez, Alberto Armijo, Ana Fernández‐Palacín, José Antonio García‐Mejido,
We believe that physiotherapy with muscle training (MT) of the postpartum pelvic floor may lead to a change in the clinical management of patients with avulsion of the puborectal portion of the levator ani muscle (LAM). Our objective is to assess whether physiotherapy with MT of the postpartum pelvic floor in patients with LAM avulsion produces changes in pelvic floor morphology evaluated by 3/4D transperineal ultrasound.This parallel randomized controlled trial (RCT) included 97 primiparous patients. ...
Tópico(s): Anorectal Disease Treatments and Outcomes
2022 - AME Publishing Company | Quantitative Imaging in Medicine and Surgery
Produção Nacional
Revisado por pares
Jesús M. Mercado, Francisco Gómez-Jakobsen, Nathalie Korbee, Antonio Avilés, José Bonomi‐Barufi, María Muñoz, Andreas Reul, Félix L. Figueroa,
Time series of temperature, salinity and nutrients in the Strait of Gibraltar (SoG) were researched to analyze which factors explain the invasive success of Rugulopteryx okamurare, which has colonized wide coastal areas at the Spanish and Moroccan coasts since 2016. Temperature and salinity were higher in the SoG compared to its native habitat, implying that the alga is active during the whole seasonal cycle and grows optimally at the high salinities occurring in the SoG. Nitrate removal experiments ...
Tópico(s): Coastal wetland ecosystem dynamics
2022 - Elsevier BV | Marine Pollution Bulletin
Mattia Giuliani, Anna Ichino, Alice Bonomi, Riccardo Maria Martoni, Stefania Cammino, Alessandra Gorini,
Crucial to the success of the COVID-19 vaccination campaign is the rate of people who adhere to it. This study aimed to investigate the reasons underlying people’s willingness to get vaccinated in a sample of Italian adults, considering the effects of different individual characteristics and psychological variables upon positive vs. negative/hesitant vaccination intentions, as well as subjects’ self-reported motivations for such intentions. An anonymous cross-sectional survey was distributed online ...
Tópico(s): Misinformation and Its Impacts
2021 - Multidisciplinary Digital Publishing Institute | Vaccines
Carmine Pinto, Paolo Andrea Zucali, Maria Pagano, Federica Grosso, Giulia Pasello, Marina Chiara Garassino, Marcello Tiseo, Héctor Soto Parrà, Francesco Grossi, Federico Cappuzzo, Filippo de Marinis, Paolo Pedrazzoli, Maria Bonomi, Letizia Gianoncelli, Matteo Perrino, Armando Santoro, Francesca Zanelli, Candida Bonelli, Antonio Maconi, Stefano Frega, Erika Gervasi, Luca Boni, Giovanni Luca Ceresoli,
There is a preclinical rationale for inhibiting angiogenesis in mesothelioma. We aimed to assess the efficacy and safety of the anti-VEGFR-2 antibody ramucirumab combined with gemcitabine in patients with pretreated malignant pleural mesothelioma.RAMES was a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial done at 26 hospitals in Italy. Eligible patients were aged 18 years or older, had Eastern Cooperative Oncology Group performance status 0-2, and histologically proven malignant ...
Tópico(s): Neuroblastoma Research and Treatments
2021 - Elsevier BV | The Lancet Oncology
Sabrina Rossi, Giovanna Finocchiaro, Vincenzo Di Noia, Maria Bonomi, Eleonora Cerchiaro, Fiorenza De Rose, Davide Franceschini, Pierina Navarria, Giovanni Luca Ceresoli, Giordano Beretta, Ettore D’Argento, Marta Scorsetti, Armando Santoro, Luca Toschi,
Aim: The association of tyrosine kinase inhibitors (TKIs) and local radiotherapy in EGFR-mutated non-small-cell lung cancer patients experiencing disease progression under TKIs could be a valid an option. Patients & methods: We included 131 patients experiencing disease progression during first-line TKI. In group A, patients received TKI beyond progression and site(s) of progression were irradiated; in group B, patients remained on TKI alone beyond progression; and group C stopped TKI at first disease ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2019 - Future Medicine | Future Oncology
José Antonio Sainz‐Bueno, José Antonio García‐Mejido, Adriana Aquise, Carlota Borrero, Maria Bonomi, Ana Fernández‐Palacín,
Complicated operative vaginal deliveries are associated with high neonatal morbidity and maternal trauma, especially if the procedure is unsuccessful and a cesarean delivery is needed. The decision to perform an operative vaginal delivery has traditionally been based on a subjective assessment by digital vaginal examination combined with the clinical expertise of the obstetrician. Currently there is no method for objectively quantifying the likelihood of successful delivery. Intrapartum ultrasound ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2018 - Elsevier BV | American Journal of Obstetrics and Gynecology
Sabrina Rossi, Luca Toschi, Giovanna Finocchiaro, Vincenzo Di Noia, Maria Bonomi, Eleonora Cerchiaro, Giovanni Luca Ceresoli, Giordano Beretta, Ettore D’Argento, Armando Santoro,
Common epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs), with exon 19 deletions being associated with better outcome compared to L858R mutations. We aimed to investigate the impact of different exon 19 deletions on patient outcome in EGFR-mutant NSCLC treated with first-line TKIs.In this retrospective analysis, 106 patients with metastatic NSCLC harboring EGFR exon 19 deletions and treated with first- ...
Tópico(s): Lung Cancer Research Studies
2018 - Elsevier BV | Clinical Lung Cancer
José Antonio Sainz‐Bueno, José Antonio García‐Mejido, Adriana Aquise, Maria Bonomi, Carlota Borrero, Paloma De La Fuente, Ana Fernández‐Palacín,
The objective of this study was to investigate the predictive value of intrapartum transperineal ultrasound in the identification of complicated operative (vacuum or forceps) deliveries in nulliparous women.Prospective observational study of nulliparous women with an indication for operative delivery who underwent intrapartum transperineal ultrasound before fetal extraction. Managing obstetricians were blinded to the ultrasound data. Intrapartum transperineal ultrasound was performed immediately ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2017 - Informa | Acta Obstetricia Et Gynecologica Scandinavica
Maria Bonomi, Costantino De Filippis, Egesta Lopci, Letizia Gianoncelli, Giovanna Rizzardi, Eleonora Cerchiaro, Luigi Bortolotti, Alessandro Zanello, Giovanni Luca Ceresoli,
Abstract: Malignant pleural mesothelioma (MPM) is a disease with limited therapeutic options, the management of which is still controversial. Diagnosis is usually made by thoracoscopy, which allows multiple biopsies with histological subtyping and is indicated for staging purposes in surgical candidates. The recommended and recently updated classification for clinical use is the TNM staging system established by the International Mesothelioma Interest Group and the International Association for the ...
Tópico(s): Medical Imaging and Pathology Studies
2017 - Dove Medical Press | Lung Cancer Targets and Therapy
Paolo Andrea Zucali, Egesta Lopci, Giovanni Luca Ceresoli, Laura Giordano, Matteo Perrino, Gianluigi Ciocia, Letizia Gianoncelli, Elena Lorenzi, Matteo Simonelli, Fabio De Vincenzo, Lucia Setti, Cristiana Bonifacio, Maria Bonomi, Emilio Bombardieri, Arturo Chiti, Armando Santoro,
Abstract The aim of this study was to evaluate the role of metabolic parameters analyzed at baseline and at interim FDG‐PET in predicting disease outcome in unresectable MPM patients receiving pemetrexed‐based chemotherapy. A consecutive series of MPM patients treated between February 2004 and July 2013 with first‐line pemetrexed‐based chemotherapy, and evaluated by FDG‐PET and CT scan at baseline and after two cycles of chemotherapy, was reviewed. Best CT scan response was assessed according to ...
Tópico(s): Medical Imaging and Pathology Studies
2017 - Wiley | Cancer Medicine
Produção Nacional
Revisado por pares
Eduardo A. Haddad, Ana Maria Bonomi Barufi,
• Workers with longer daily commuting are less productive. • Workers with higher accessibility to jobs are more productive. • Policy choices in the past may impose strong costs to spatial sustainability in the present. • Geography and history reinforced the patterns of inequality of opportunity in the labor market in SPMR.
Tópico(s): Spatial and Panel Data Analysis
2017 - Elsevier BV | Habitat International