Raymond Snoddy Media Editor, Joanna Hunter, John Williams, (Assistant Secretary, Layfield Committee), Richard Whitehead, Portia Colwell, K. T. Norcott, Le Gallois, Andrew Pierce, Mike Spence, Brian Greer, Adrian Lee, Rob Hughes, Sarah Potter, Nigel Colborn, Jez Ford, Daisy Waugh, Jane MacQuitty, Simon Barnes, Gary Neville, John Morgan, Paul Hoggart, Richard Hobson, Jonathan Noakes, Karen Woolfson, Ivo Tennant, Gavin Lumsden, Matt Gibson, Richard Otley, Philip Howard, Dominic Kennedy and Helen Rumbelow, Hannah Betts, Gary Ansell, Russell Jenkins North-West Correspondent, Jeremy Kingston, James Bone, David Stokes, Kate Reardon, Guy Mortimer, Richard Eaton, Michael Evans, Defence Editor, Dominic Bradbury, Kevin Eason, Christine Buckley Industrial Correspondent, John Stewart, Chairman, Raymond Snoddy, Gerald Davies, Clare Stewart, Roland Watson Political Correspondent, Giles Coren, Peter Wilson, John Thicknesse, Pat Gibson, Paul Fitzpatrick, Noam Friedlander, Diane Wilson, Robert Sheehan, D. R., Steve Keenan, robin eggar, Dominic Walsh, Jerome Boyd Maunsell, Shirley English, Debra Craine, Stephen Geraint, Mike Pattenden, Anne Ashworth, Personal Finance Editor, Alix Ramsay Tennis Correspondent, Nick Nuttall Technology Correspondent, Richard Ford Home Correspondent, Peter Hughes, Candida Crewe, Stephen Farrell, Alan Hamilton, Nicholas Davidson, Jenny MacArthur, T. P., Alice Lagnado, John O'Leary, Eve-Ann Prentice, Jayne Dowle, James Landale Political Correspondent, Jonathan Hart, barry j holmes, Keith Pike, Frances Bissell, Fraser Nelson and Arthur Leathley, David Hands, P. B., Jason Allardyce, Scottish Political Reporter, Helen Foster, John Fletcher, Fiona Fleck, Peter Barnard, Paul Rider, Simon Beckett, Derwent May, Victoria Fletcher, peter zownir, Jasper Gerard, Russell Kempson, Paula Hawkins, Maria Harding, Daniel McGrory, Paul Armstrong, Nicole Swengley, Richard Colwill, Tony Lyons, Paul Durman, Stephen Anderton, Michael Lynagh, Chris Smith, Rowan O'neill, Adam Edwards, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Melanie Bien, Stephen Wood, John Beyer, Adam Jones, Ann Wickham, Raymond Keene, Daniel Roper, Christine Buckley, Matthew Pryor, John Russell Taylor, David Robinson, Matt Dickinson, Paul Wilkinson, Stefano Hatfield, James Allcock, Jeannette Hyde, Pamela Spearing, Arabella Warner, Clive Petty, Caroline Merrell, Nigel Hawkes, Robert Stevens, Oliver James, James Bennett, Oliver Holt, Richard Owen, John Pitcher, Gerald Burke, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Diana Bentley, David Kettle, Roger Boyes, Nigel Hawkes, Science Editor, Sarah Cunningham, Martin Woods, John Cherry, Louise Nicholson, Jamie Terrell, John diamond, Stephanie Billen, Dalya Alberge, Oliver Holt, Football Correspondent, Adam Fresco, Henry Harris's, Nick Szczepanik, David Young, David Churchill, Giles Whittell, Christopher Walker, James Pringle, Saeed Shah, Jason Nissé, Kevin McCarra, Matthew Parris, Andre Camara, Jeanne Kerr, Mark Hodkinson, Anna Franklyn, George Caulkin, Chris McGrath, Tim Wapshott, F. R. Smale, Clarissa Hyman, Alan Lee, Ben MacIntyre, Helen Pridham, Paul Sebastian, Richard Beeston, David Bowker, Richard Miles, Graham Searjeant, Lea Paterson, Fraser Nelson, Tom Jones, Tim Jones, Michael Binyon, Diplomatic Editor, Mark Henderson, Christopher Harrison, Martin Waller, Geoffrey Rowell, Danny Baker, Eric Phillips, Mark Baldwin, Fran Littlewood, Lottie Moggach, Ian S. Menzies, Benedict Nightingale, Jill Crawshaw, Andrew Bartlett, Alyson Rudd, Chris Moore, Jack Bailey, Joe Warwick, Tom Chesshyre, Paul Connolly, Fred Dellar, Alex O'connell, mick armson, Michael Evans, Alasdair Murray, Susie Steiner, Sally Patten, Tony Kelly, Cath Urquhart Travel Editor, Richard Knight, Penny Perrick, Walter Ellis, Colin McQuillan, Terry George, Lisa Verrico, Helen Rumbelow and Dominic Kennedy, Susan Emmett,
... Lee Evans Exhibitions Major/museums The Big Show: Clementina Lady Hawarden Don't Miss Vh RG Royal ...
1999 - Gale Group | TDA
Silvia Baroncelli, P. Villani, Liliana Elena Weimer, Nicoletta Ladisa, Daniela Francisci, Chiara Tommasi, Vincenzo Vullo, Roberta Preziosi, Stefania Cicalini, Maria Cusato, Clementina Maria Galluzzo, Marco Floridia, Mario Regazzi,
BACKGROUND: Raltegravir and maraviroc represent new, important resources for HIV-infected patients with intolerance or resistance to other antiretroviral agents. The safety and efficacy of both drugs have been investigated, but there is no information on possible pharmacokinetic interactions between these 2 drugs in clinical practice. OBJECTIVE: To evaluate raltegravir plasma concentrations in heavily treatment-experienced patients receiving salvage regimens and explore, in a preliminary assessment, ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2010 - SAGE Publishing | Annals of Pharmacotherapy
"D. JORDAN.", CLEMENTINA BLACK., BEATRICE M. SAMUEL, , STANHOPE., G. TITUS BARHAM., EDWARD A. WILSON., JOHN H. WALTER., MILLICENT GARRETT FAWCETT, , LAW AND ORDER., D. A. LYNCH., SIDNEY LEE., ALICE O. WOODS., JOSEPH H. HERTZ., G. L. BRUCE., HENRY E. J. BEVAN., D. C. LATHBURY., BY J. A. JENKINSON AND CHARLES TRAVIS., ASHURST, MORRIS, CRISP, , FRANK MORRIS., SIDNEY S. KENNEDY., FRANK HYLAND., P. A. PETERSEN., "M.",
... Street Physician As Beneficiary. In The Estate Of Maria Mattingley, Deceased-Starke v. Clark And Others., Posing ...
1913 - Gale Group | TDA
E.M. Galati, M.T. Monforte, Natalizia Miceli, Monica Mondello, Maria Fernanda Taviano, Clementina Maria Galluzzo, M.M. Tripodo,
Abstract Opuntia ficus indica cladodes possess a protective action against ethanol‐induced ulcer in the rat. The major components of cladodes are carbohydrate polymers, mainly mucilages and pectin. To clarify the cytoprotective effects of cladodes on experimental ethanol‐induced ulcer in rat, mucilages and pectin were extracted and were administered instead of cladodes. The above mentioned effects induced by cladodes may be attributed to mucilages, and not significantly to pectin. Copyright © 2007 ...
Tópico(s): Botany, Ecology, and Taxonomy Studies
2007 - Wiley | Phytotherapy Research
E.M. Galati, Monica Mondello, Eugenia Rita Lauriano, Maria Fernanda Taviano, Clementina Maria Galluzzo, Natalizia Miceli,
The protective effects of the juice of Opuntia ficus indica fruit (prickly pear) against carbon tetrachloride (CCl4)-induced hepatotoxicity were examined in rats. The animals were treated orally with the juice (3 mL/rat) 2 h after administration of the hepatotoxic agent. Preventive effects were studied by giving the juice (3 mL/rat) for 9 consecutive days. On day 9 the rats received the hepatotoxic agent. Morphological and biochemical evaluations were carried out 24, 48 and 72 h after induction of the ...
Tópico(s): Cassava research and cyanide
2005 - Wiley | Phytotherapy Research
Lucia Palmisano, Marina Giuliano, Emanuele Nicastri, Maria Franca Pirillo, Mauro Andreotti, Clementina Maria Galluzzo, Raffaella Bucciardini, Vincenzo Fragola, Massimo Andreoni, Stefano Vella,
To determine factors associated with < 2.5 copies/ml plasma HIV RNA in subjects treated with highly active antiretroviral therapy (HAART) and with viraemia < 50 copies/ml.Cross-sectional analysis of 84 HIV-positive patients taking HAART with plasma HIV RNA < 50 copies/ml for at least 6 months and no history of virological failure.Current HAART therapy was based on a non-nucleoside reverse transcriptase inhibitor (NNRTI) in 66%, a protease inhibitor in 26% and nucleoside reverse transcriptase inhibitors ...
Tópico(s): HIV/AIDS Research and Interventions
2005 - Lippincott Williams & Wilkins | AIDS
Annita Pintor, Maria Teresa Tebano, Alberto Martire, Rosa Grieco, Clementina Maria Galluzzo, María Luisa Scattoni, Antonella Pèzzola, Roberto Coccurello, Fabio Felici, V. Cuomo, Daniele Piomelli, Gemma Calamandrei, Patrizia Popoli,
The ability of CB1 receptors to regulate the release of glutamate in the striatum, together with the finding that, in experimental models of Huntington disease (HD), both endocannabinoid levels and CB1 receptor densities are reduced, has prompted the investigation on the neuroprotective role of the cannabinoids in HD. Quinolinic acid (QA) is an excitotoxin that, when injected in the rat striatum reproduces many features of HD and that acts by stimulating glutamate outflow. The aim of the present study ...
Tópico(s): Genetic Neurodegenerative Diseases
2006 - Elsevier BV | Neuropharmacology
Catarina Tomás, Emanuel Oliveira, Daniellen Cristina Ferreira Sousa, Matheus Uba Chupel, Guilherme Eustáquio Furtado, Clara Rocha, Ana Teixeira, Pedro Lopes Ferreira, C. Alves, Stefan Gisin, Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Américo Silva Bonfim, Carina Silva, Débora Franco, Jesús Alcoba González, Maria Helena de Agrela Gonçalves Jardim, Rita Silva, Cristina Lavareda Baixinho, Ma Helena Presado, Ma Fátima Marques, Mário E. Cardoso, Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto, João Frade, Carla Nunes, João R. Mesquita, María Säo José Nascimento, Guilherme Gonçalves, Conceição Castro, Alice Mártires, M. João Monteiro, Conceição Rainho, Francisco P. Caballero, Fátima M. Monago, José T. Guerrero, Rocio M. Monago, Africa P. Trigo, Milagros L. Gutierrez, Gemma M. Milanés, Mercedes G. Reina, Ana G. Villanueva, Ana S. Piñero, Isabel R. Aliseda, Francisco Buitrago Ramírez, Andrea Ribeiro, Ana Quelhas, Maria Conceição Manso, Francisco P. Caballero, José T. Guerrero, Fátima M. Monago, Rafael Brito Santos, Nuria R. Jimenez, Cristina G. Nuñez, Inmaculada Rodríguez Gómez, Ma Jose L. Fernandez, Laura A. Marquez, Ana L. Moreno, Ma Jesus Tena Huertas, Francisco Buitrago Ramírez, Daniel Seabra, Ma Céu Salvador, Luciene Muniz Braga, Pedro Parreira, Anabela Salgueiro‐Oliveira, Cristina Arreguy-Sena, Bibiana F. Oliveira, Ma Adriana Henriques, Joana Santos, Sara Lebre, Alda Marques, Clarinda Festas, Sandra Rodrigues, Andrea Ribeiro, José Lumini‐Oliveira, Ana Gabriela Figueiredo, Francisco J. Hernandez-Martinez, Liliana Campi, Ma Pino Quintana-Montesdeoca, Juan F. Jimenez-Diaz, Bienvenida C. Rodriguez-De-Vera, Alexandra Parente, Ma Augusta Mata, Ana Ma Pereira, Adília Fernandes, Manuel Brás, Ma Rosário Pinto, Pedro Parreira, Marta Lima Basto, Ana C. Rei, Lisete Mónico, Gilberta Sousa, Clementina Morna, Otília Freitas, Gregório Freitas, Ana Carolina Gomes Jardim, Rita P. Vasconcelos, Lina G. Horta, Roger dos Santos Rosa, Luís Fernando Kranz, Rita C. Nugem, Mariana Santiago Siqueira, Ronaldo Bordin, Rosiane Kniess, Josimari Telino de Lacerda, Joana Guedes, Idalina Machado, Sidalina Almeida, Adriano Zilhão, Hélder Alves, Óscar Ribeiro, Ana Paula Martins Amaral, Ana Maria Ribeiro dos Santos, Joana Monteiro, Ma Clara Rocha, Rui Cruz, Ana Paula Martins Amaral, Marina Lourenço, Ma Clara Rocha, Rui Cruz, Sandra Regina Masetto Antunes, Verónica Mendonça, Isabel Andrade, Nádia Osório, Ana Valado, Armando Caseiro, Antonio Padua y Gabriel, Anabela Correia Martins, Fernando Mendes, Lídia Cabral, Manuela Ferreira, Amadeu Gonçalves, Tatiana Durão D`Ávila Luz, Leonardo Gomes de Oliveira Luz, Raúl A. Martins, Alice Murteira Morgado, Maria da Luz Vale-Dias, Rui Porta-Nova, Tânia Cristina Malezan Fleig, Éboni Marília Reuter, Miriam Beatris Froemming, Sabrina Luciane Camara Guerreiro, Lisiane Lisbôa Carvalho, Daniel Guedelha, Pedro S. Coelho, A.T. Pereira, António Calha, Raúl Cordeiro, Ana Gonçalves, Ana Certo, Ana Cristina Araújo de Andrade Galvão, Ma Augusta Mata, Aline Welter, Elayne Crestani Pereira, Sandra Aparecida Ribeiro, Márcia Regina Kretzer, Juan-Fernando Jiménez-Díaz, Carla Jiménez-Rodríguez, Francisco-José Hernández-Martínez, Bienvenida-Del-Carmen Rodríguez-De-Vera, Alexandre Marques-Rodrigues, Patrícia Brazil Pereira Coelho, Tiago Bernardes, Alexandre de Araújo Pereira, Patrícia Sousa, João Ghizzo Filho, Nazaré Otília Nazário, Márcia Regina Kretzer, Odete Amaral, António Garrido, Nélio Veiga, Carla Nunes, Ana Rita Pedro, Carlos Pereira, António Almeia, Hélder Miguel Fernandes, Carlos Vasconcelos, Nélson Sousa, Víctor Machado Reis, M. João Monteiro, Romeu Mendes, Isabel Pinto, Tânia C. S. P. Pires, João Gama, Vera Preto, Norberto Silva, Carlos Pires Magalhães, Matilde Martins, Mafalda Duarte, Constança Paúl, Ignácio Martín, Arminda Pinheiro, Sandra Doria Xavier, J. Azevedo, E. Bento, C. Marques, M. Marques, A. Macedo, A.T. Pereira, José Pedro Almeida, António Almeida, Josiane Alves, Nélson Sousa, Francisco Saavedra, Romeu Mendes, Ana S. Maia, Michelle Teixeira Oliveira, Anderson Reis de Sousa, Paulo P. Ferreira, Luci S. Lopes, Eujcely C. Santiago, Sílvia Monteiro, Ângelo Jesus, Armanda Colaço, Antônio Ivo de Carvalho, Rita P. Silva, Agostinho Cruz, Ana Ferreira, Catarina Marques, João Paulo Figueiredo, Susana Paix�ão, Ana Ferreira, Carla Lopes, Fernando Moreira, João Paulo Figueiredo, Ana Ferreira, Diana Ribeiro, Fernando Moreira, João Paulo Figueiredo, Susana Paix�ão, Telma Fernandes, Diogo Amado, Jéssica Denise Vieira Leal, Marcelo Costa Velho Mendes de Azevedo, Sónia Ramalho, Catarina Mangas, Jaime Ribeiro, Rita Maria de Abreu Gonçalves, Amélia Fernandes Nunes, Ana Rita Tuna, Carlos Martins, Henriqueta D. Forte, Cláudia Costa, José António Tenedório, Paula Santana, José Augusto Andrade, Joana Pinto, C. Campofiorito, S. C. Nunes, Ana Sofia Carmo, A. Kaliniczenco, Bárbara Erllen da Silva Alves, Francisco Mendes, Carlos Jesus, Felipe Paiva Fonseca, Flávia de Sousa Gehrke, Carlos Albuquerque, Rita Batista, Madalena Cunha, António Dias, Olivério Ribeiro, Rosa Maria Grangeiro Martins, Teresa Madeira, Catarina Peixoto-Plácido, Nuno Rebelo dos Santos, Osvaldo Santos, Astrid Bergland, Asta Bye, Carla Lopes, Violeta Alarcão, Beatriz Goulão, Nuno Mendonça, Paulo Nicola, J. Gorjão Clara, João Gomes, Ana Querido, Catarina Tomás, Daniel Carvalho, Marina Cordeiro, Marlene Rosa, Alda Marques, Daniela Brandão, Óscar Ribeiro, Lia Araújo, Constança Paúl, Beatriz Minghelli, Sylvina Richaud, Ana Laura Mendes, Joana Marta‐Simões, Inês A. Trindade, Cláudia Ferreira, Teresa Carvalho,
S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion ...
BioMed Central
Maurizio Cianfriglia, Maria Luisa Dupuis, Agnese Molinari, Antonio Verdoliva, Roberta Costi, Clementina Maria Galluzzo, Mauro Andreotti, Andrea Cara, Roberto Di Santo, Lucia Palmisano,
The discovery of diketoacid-containing derivatives as inhibitors of HIV-1 Integrase (IN) (IN inhibitors, IINs) has played a major role in validating this enzyme as an important target for antiretroviral therapy. Since the in vivo efficacy depends on access of these drugs to intracellular sites where HIV-1 replicates, we determined whether the IINs are recognized by the multidrug transporter MDR1-P-glycoprotein (P-gp) thereby reducing their intracellular accumulation. To address the effect of IINs on ...
Tópico(s): HIV Research and Treatment
2007 - BioMed Central | Retrovirology
Paola Casolini, Maria Rosaria Domenici, Carlo Cinque, G Alemà, Valentina Chiodi, Clementina Maria Galluzzo, Maria Musumeci, Jérôme Mairesse, Anna Rita Zuena, P. Matteucci, Giuseppe Marano, Stefania Maccari, Ferdinando Nicoletti, A. Catalani,
A growing body of evidence underscores the importance of early life events as predictors of health in adulthood. Abnormalities in maternal care or other forms of early postnatal stress induce long-term changes in behavior and influence the vulnerability to illnesses throughout life. Some of these changes may be produced by the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which is invariably associated with stress. We used a model in which neonate rats are fed by mothers drinking water ...
Tópico(s): Tryptophan and brain disorders
2007 - Society for Neuroscience | Journal of Neuroscience
Raffaella Bucciardini, Albert W. Wu, Marco Floridia, Vincenzo Fragola, D. Ricciardulli, Carlo Tomino, Liliana Elena Weimer, Maria Franca Pirillo, M. Mirra, Massimo Marzi, Giacomo Giannini, Clementina Maria Galluzzo, Mauro Andreotti, Maurizio Massella, Stefano Vella,
Objectives To evaluate the quality of life outcomes in antiretroviral-naive patients randomized to zidovudine plus didanosine versus zidovudine plus didanosine plus nevirapine for treatment of advanced HIV disease (the Istituto Superiore di Sanità 047 trial). Design A 48-week randomized, double-blind trial. Methods Sixty patients were enrolled and evaluated over 24 weeks. Quality of life was assessed using a modified version of the Medical Outcomes Study-HIV Health Survey. For analysis, we calculated ...
Tópico(s): HIV Research and Treatment
2000 - Lippincott Williams & Wilkins | AIDS
Marco Floridia, Raffaella Bucciardini, D. Ricciardulli, Vincenzo Fragola, Maria Franca Pirillo, Liliana Elena Weimer, Carlo Tomino, Giacomo Giannini, Clementina Maria Galluzzo, Mauro Andreotti, A. Cargnel, F Alberici, Bruno De Rienzo, F Leoncini, F Fiaccadori, Daniela Francisci, W Grillone, L Ortona, M Piazza, Alfredo Scalzini, E. Nigra, Fabio Tumietto, Stefano Vella,
Summary: The immunologic and virologic activity of nevirapine in combination with two nucleosides (zidovudine [ZDV] and didanosine [ddI]) was evaluated in antiretroviral-naive patients with a CD4 count <200/mm3 or clinical AIDS. In all, 68 patients were enrolled in a 48-week double-blind, placebo-controlled trial. A group of 32 patients received ZDV + ddI + nevirapine, and 36 patients received ZDV + ddI. Primary efficacy parameters were the activity on HIV-1 RNA and on peripheral blood CD4+ cells, with differences ...
Tópico(s): HIV/AIDS Research and Interventions
1999 - Lippincott Williams & Wilkins | Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology
Leonardo Palombi, Maria Franca Pirillo, Emilia Marchei, Haswell Jere, Jean‐Baptiste Sagno, Richard Luhanga, Marco Floridia, Mauro Andreotti, Clementina Maria Galluzzo, Simona Pichini, Ruben Mwenda, S Mancinelli, Maria Cristina Marazzi, Stefano Vella, Giuseppe Liotta, Marina Giuliano,
To evaluate antiretroviral drug concentrations in mothers and infants enrolled under the Option B-Plus approach for the prevention of HIV mother-to-child transmission in Malawi and to assess the maternal virological response after 1 year of treatment. Forty-seven women and 25 children were studied. Mothers were administered during pregnancy a combination of tenofovir, lamivudine and efavirenz and continued it during breastfeeding (up to 2 years) and thereafter. Drug concentrations were evaluated ...
Tópico(s): HIV Research and Treatment
2015 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Leonardo Palombi, Maria Franca Pirillo, Mauro Andreotti, Giuseppe Liotta, Fulvio Erba, Jean‐Baptiste Sagno, Martin Maulidi, Susanna Ceffa, Haswell Jere, Emilia Marchei, Simona Pichini, Clementina Maria Galluzzo, Maria Cristina Marazzi, Stefano Vella, Marina Giuliano,
Limited information is available on antiretroviral concentrations in women/infant pairs receiving prophylaxis for breastfeeding transmission of HIV and on the relationship between drug levels and the virological and haematochemistry parameters.Patient population included HIV-positive pregnant women receiving antiretroviral prophylaxis from gestational week 25 until 6 months after delivery and their breastfed infants. Blood and breast milk samples were collected at delivery, and at months 1, 3 and ...
Tópico(s): HIV Research and Treatment
2012 - SAGE Publishing | Antiviral Therapy
Francesca Romana Mauro, Diana Giannarelli, Clementina Maria Galluzzo, Candida Vitale, Andrea Visentin, Costantino Riemma, Serena Rosati, Marika Porrazzo, Sara Pepe, Marta Coscia, Livio Trentin, Massimo Gentile, Sara Raponi, Alessandra Micozzi, Giuseppe Gentile, Silvia Baroncelli,
Tópico(s): Lymphoma Diagnosis and Treatment
2020 - Springer Nature | Leukemia
Daniela Angela Covino, Cristina Purificato, Laura Catapano, Clementina Maria Galluzzo, Maria Cristina Gauzzi, Stefano Vella, Éric Lefebvre, Star Seyedkazemi, Mauro Andreotti, Laura Fantuzzi,
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) family members are cytidine deaminases that play crucial roles in innate responses to retrovirus infection. The mechanisms by which some of these enzymes restrict HIV-1 replication have been extensively investigated in vitro. However, little is known regarding how APOBEC3 proteins affect the pathogenesis of HIV-1 infection in vivo and how antiretroviral therapy influences their expression. In this work, a longitudinal analysis ...
Tópico(s): Cytomegalovirus and herpesvirus research
2018 - Frontiers Media | Frontiers in Immunology
Annalisa Trama, Roberto Boffi, Paolo Contiero, Carlotta Buzzoni, Roberta Pacifici, Lucìa Mangone, Vincenzo Coviello, Carlotta Buzzoni, Mario Fusco, Alessandro Barchielli, Francesco Cuccaro, Roberta De Angelis, Adriano Giacomin, Stefano Luminari, G. Randi, Lucìa Mangone, Guido Mazzoleni, A. Bulatko, E. Devigili, B Tschugguel, E De Valiere, G Facchinelli, Martin Falk, Fabio Vittadello, Vincenzo Coviello, Francesco Cuccaro, Angela Calabrese, Anna Di Pinto, Giorgio Cannone, M. Vitali, Rocco Galasso, Luciana Del Riccio, Domenico Napolitano, Giuseppe Sampietro, S Ghisleni, L Giavazzi, Anne Zanchi, Alberto Zucchi, Adriano Giacomin, Pc Vercellino, Sara Andreone, Monica Fedele, Antonella Barale, F Germinetti, Michele Magoni, O Salvi, M Puleio, C Gerevini, R Chiesa, Fulvio Lonati, Luca Cavalieri d’Oro, M Rognoni, L Rose, E Merlo, A Bracchi, L Negrino, Laura Pezzuto, A Ardizzone, G Spagnolo, Emma Cozzi, L De Lorenzism, F Lotti, MC Pagliara, Angelo D’Argenzio, M D'Abronzo, Davide De Francesco, MCM Pereira da Silva, Vincenzo G. Menditto, E. Perrotta, MT Pesce, Aurelio Sessa, Salvatore Sciacca, Salvatore Sciacchitano, M Fidelbo, Giacomo Di Benedetto, A. Benedetto, L Calabretta, AM Caruso, Marine Castaing, AA Di Prima, YM Dinaro, P Fidelbo, Giuseppe Grosso, A Ippolito, Eleonora Irato, Antonio Leone, F Paderni, P. Pesce, Sebastiano Pollina Addario, A Savasta, C Sciacchitano, A Torrisi, A Torrisi, Massimo Varvarà, C Viscosi, Angela Sardo, Alex Tiong Heng Sia, Santo Scalzi, AM Lavecchia, Pamela Mancuso, V. Nocera, Francesco Mancusi, Sergio Duca, G Gola, M Corti, Maria Clara Caparelli, Stefano Ferretti, L Marzola, E Migliari, N Carletti, Patrizia Biavati, Cara Petrucci, Diego Serraino, T Angelin, Ettore Bidoli, Silvia Birri, Luigino Dal Maso, Margherita de Dottori, E De Santis, O Forgiarini, Antonella Zucchetto, Loris Zanier, Fabio Pannozzo, S. Busco, Marta Rossi, S Curatella, E Bugliarello, L Macci, E Bernazza, Francesca Calabretta, S Tamburrino, Isabella Sperduti, L Tamburo, Gianluca Serafini, F Quarta, Anna Melcarne, MG Golizia, C Arciprete, Vanda Maria, R. Filiberti, Claudia Casella, Enza Marani, Antonella Puppo, Mv Celesia, R Cogno, Susanna Vitarelli, Paolo Ricci, M. Autelitano, Sara Ghilardi, Roberto Leone, L Filipazzi, A Bonini, C Giubelli, Antonio Russo, Michael R. Quattrocchi, R Distefano, Emerico Panciroli, Alice Bellini, Michele Pinon, S Spinosa, Gianbattista Spagnoli, Giuliano Carrozzi, Claudia Cirilli, K Valla, Veronica Amendola, Mario Fusco, C Bellatalla, Valerio Ciullo, Marco Di Buono, Mario Fusco, MariaGrazia Panico, C Perrotta, M.F. Vitale, M. Usala, Filomena Pala, Gm Sini, Nicholas Pintori, L Canu, G Demurtas, N Doa, Francesco Vitale, Rosanna Cusimano, A. Traina, A Guttadauro, MA Cascio, Rita Mannino, Barbara Ravazzolo, MA Brucculeri, Giuseppa Rudisi, M Adamo, Rosalba Amodio, Ana Rute Costa, Maurizio Zarcone, R Sunseri, G Bucalo, C Trapani, R. Staiti, Maria Michiara, F Bozzani, Paolo Sgargi, Lorenza Boschetti, Simona Migliazza, Enrico Reggiani, N Incardona, Elisabetta Borciani, Pietro Seghini, R Prazzoli, Roberto Zanetti, S Rosso, S Patriarca, Rosanna Prandi, I Sobrato, F Gilardi, P Busso, Lidia Sacchetto, Rosario Tumino, Giuseppe Cascone, Graziella Frasca, MC Giurdanella, Caterina Martorana, Giovanni Morana, Carmela Nicita, P Rollo, MG Ruggeri, Eugenia Spata, Sara Rita Vacirca, Lucìa Mangone, Massimo Vicentini, E. Di Felice, Annamaria Pezzarossi, Francesca Ferrari, Francesca Roncaglia, Claudio Sacchettini, Stefania Caroli, Fabio Falcini, Americo Colamartini, Lauro Bucchi, Maria Michiara, Marcello Ravegnani, Benedetta Vitali, C Cordaro, L Caprara, Orietta Giuliani, Sabrina Giorgetti, Michael Palumbo, Rosa Vattiato, Alessandra Ravaioli, Silvia Mancini, AL Caiazzo, Rossella Cavallo, AFG Colavolpe, Antonio d’Alessandro, Antonio Iannelli, Claudio Lombardo, G Senatore, Flavio Sensi, R. Cesaraccio, D Pirino, Francesco Mura, M.L. Contrino, A Madeddu, F. Tisano, YM Dinaro, Alfredo Muni, M Mizzi, F. Bella, L Rossitto, G Sacco, P Aletta, Antonio Ziino, S. Maspero, A.C. Fanetti, I Cometti, L Cecconami, Sante Minerba, Antonia Mincuzzi, Simona Carone, Margherita Tanzarella, Clementina Maria Galluzzo, Alessandro Barchielli, Carlotta Buzzoni, Adele Caldarella, A Corbinelli, T. Intrieri, PP Di Dia, Gianfranco Manneschi, L Nemcova, Carmen Beatriz Visioli, Marco Zappa, Giuseppa Candela, T. Scuderi, G Crapanzano, Viktoria Taranto, Silvano Piffer, M Gentilini, R Rizzello,
The epidemiology of lung cancer is changing worldwide, with smoking being the key driver of lung cancer incidence and mortality. Our aim is to analyze the incidence, survival and mortality trends in Italy in the framework of the 2017 survey on smoking behavior in Italy.AIRTUM 2017 reports on cancer survival and incidence; 2017 survey on smoking behavior in Italy.Men achieved progress in lung cancer control characterized by a decrease in incidence and mortality and an increase in survival. The decreasing ...
SAGE Publishing
Gabriella d’Ettorre, Silvia Baroncelli, Luca Micci, Giancarlo Ceccarelli, Mauro Andreotti, Prachi Sharma, Gianfranco Fanello, Fausto Fiocca, Eugenio Nelson Cavallari, Noemi Giustini, Alessandra Mallano, Clementina Maria Galluzzo, Stefano Vella, Claudio Maria Mastroianni, Guido Silvestri, Mirko Paiardini, Vincenzo Vullo,
Introduction During HIV infection the severe depletion of intestinal CD4+ T-cells is associated with microbial translocation, systemic immune activation, and disease progression. This study examined intestinal and peripheral CD4+ T-cell subsets reconstitution under combined antiretroviral therapy (cART), and systemic immune activation markers. Methods This longitudinal single-arm pilot study evaluates CD4+ T cells, including Th1 and Th17, in gut and blood and soluble markers for inflammation in HIV- ...
Tópico(s): Immune Cell Function and Interaction
2014 - Public Library of Science | PLoS ONE
Gabriella d’Ettorre, Marco Francone, Massimo Mancone, Giancarlo Ceccarelli, Adriano Ascarelli, Francesco Vullo, Silvia Baroncelli, Clementina Maria Galluzzo, Carlo Catalano, Stefano Strano, Francesco Fedele, Claudio Maria Mastroianni, Lucia Palmisano, Vincenzo Vullo,
increased incidence of acute coronary events, high rate of abnormal surrogate markers of atherosclerosis and increased amount of coronary calcium have been described in HIV infected population. To expand knowledge on coronary artery disease (CAD) in HIV patients, cardiac CT scan was performed in asymptomatic subjects with low cardiovascular (CV) risk.A cross-sectional study using dual-source CT (MDCT) coronary angiography.was conducted in HIV-infected subjects with the following characteristics: Framingham ...
Tópico(s): HIV-related health complications and treatments
2011 - Elsevier BV | Journal of Infection
Zuleika Michelini, Clementina Maria Galluzzo, Donatella Negri, Pasqualina Leone, Roberta Amici, Roberta Bona, Vincenzo Summa, Roberto Di Santo, Roberta Costi, Yves Pommier, Christophe Marchand, Lucia Palmisano, Stefano Vella, Andrea Cara,
Macrophages represent an important site for productive infection of HIV-1 and the evaluation of integrase (IN) inhibitors on this cell subset is of fundamental importance. In this report, preclinical evaluation of IN inhibitors on primary human macrophages was attempted successfully using a 96-well microtiter phenotypic assay developed recently for the evaluation of IN inhibitors in a cell-based system by taking advantage of HIV-derived lentiviral vectors expressing luciferase. IN inhibitors were ...
Tópico(s): HIV/AIDS Research and Interventions
2010 - Elsevier BV | Journal of Virological Methods
Lucia Palmisano, Clementina Maria Galluzzo, Marina Giuliano,
To the Editor: In the September first issue of Journal of Acquired Immune Deficiency Syndrome, RS Diaz et al1 report the detection of resistance mutations in the proviral DNA of patients with plasma viremia levels below 400 copies per milliliter at the end of a clinical trial of indinavir-based highly active antiretroviral therapy (HAART). Because the limit of detection of the assay used for measuring HIV RNA was 400 copies per milliliter, the authors could not rule out the possibility that low-level ...
Tópico(s): HIV/AIDS Research and Interventions
2009 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Silvia Baroncelli, Clementina Maria Galluzzo, Maria Franca Pirillo, Maria Grazia Mancini, Liliana Elena Weimer, Mauro Andreotti, Roberta Amici, Stefano Vella, Marina Giuliano, Lucia Palmisano,
Recent data have shown that plasma levels of lipopolysaccharide (LPS) are a quantitative indicator of microbial translocation in HIV infected individuals. To assess the impact of residual viral replication on plasma LPS in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA and to evaluate LPS changes during repeated HAART interruptions not exceeding 2-month duration. LPS was measured in 44 HIV+ subjects at T0 (during HAART) and at day 15 of the first and fourth HAART interruption. Ten uninfected, ...
Tópico(s): HIV/AIDS drug development and treatment
2009 - Elsevier BV | Journal of Clinical Virology
Roberto Di Santo, Roberta Costi, Alessandra Roux, Gaetano Miele, Giuliana Cuzzucoli Crucitti, Alberto Iacovo, Federica Rosi, Antonio Lavecchia, Luciana Marinelli, Carmen Di Giovanni, Ettore Novellino, Lucia Palmisano, Mauro Andreotti, Roberta Amici, Clementina Maria Galluzzo, Lucia Nencioni, Anna Teresa Palamara, Yves Pommier, Christophe Marchand,
Novel quinolinonyl diketo acids were designed to obtain integrase (IN) inhibitors selectively active against the strand transfer (ST) step of the HIV integration process. Those new compounds are characterized by a single aryl diketo acid (DKA) chain in comparison to 4, a bifunctional diketo acid reported by our group as an anti-IN agent highly potent against both the 3′-processing and ST steps. Compound 6d was the most potent derivative in IN enzyme assays, while 6i showed the highest potency against ...
Tópico(s): Biochemical and Molecular Research
2008 - American Chemical Society | Journal of Medicinal Chemistry
Lucia Palmisano, Marina Giuliano, Raffaella Bucciardini, Vincenzo Fragola, Mauro Andreotti, Clementina Maria Galluzzo, Maria Franca Pirillo, Liliana Elena Weimer, Romano Arcieri, Elena Germinario, Roberta Amici, Maria Grazia Mancini, Antonella d’Arminio Monforte, Francesco Castelli, P Caramello, Stefano Vella,
Factors influencing the outcome of structured treatment interruptions (STIs) in HIV chronic infection are not fully elucidated.In ISS-PART, 273 subjects were randomly assigned to arm A (137 assigned to continuous highly active antiretroviral therapy [HAART]) and arm B (136 assigned to 5 STIs of 1, 1, 2, 2, and 3 months' duration, each followed by 3 months of therapy). Main outcome measures were the proportion of subjects with a CD4 count >500 cells/mm3, the rate of virologic failure, and the emergence ...
Tópico(s): HIV Research and Treatment
2007 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Roberto Di Santo, Roberta Costi, Alessandra Roux, Marino Artico, Antonio Lavecchia, Luciana Marinelli, Ettore Novellino, Lucia Palmisano, Mauro Andreotti, Roberta Amici, Clementina Maria Galluzzo, Lucia Nencioni, Anna Teresa Palamara, Yves Pommier, Christophe Marchand,
The virally encoded integrase protein is an essential enzyme in the life cycle of the HIV-1 virus and represents an attractive and validated target in the development of therapeutics against HIV infection. Drugs that selectively inhibit this enzyme, when used in combination with inhibitors of reverse transcriptase and protease, are believed to be highly effective in suppressing the viral replication. Among the HIV-1 integrase inhibitors, the beta-diketo acids (DKAs) represent a major lead for anti- ...
Tópico(s): Click Chemistry and Applications
2006 - American Chemical Society | Journal of Medicinal Chemistry
Roberta Bona, Mauro Andreotti, Viviana Buffa, Pasqualina Leone, Clementina Maria Galluzzo, Roberta Amici, Lucia Palmisano, Maria Grazia Mancini, Zuleika Michelini, Roberto Di Santo, Roberta Costi, Alessandra Roux, Yves Pommier, Christophe Marchand, Stefano Vella, Andrea Cara,
Therapeutic strategies aimed at inhibiting human immunodeficiency virus type 1 (HIV-1) replication employ a combination of drugs targeted to two viral enzymes (reverse transcriptase and protease) and to the viral entry/fusion step. However, the high propensity of HIV-1 to develop resistance makes the development of novel compounds targeting different steps of the HIV-1 life cycle essential. Among these, integrase (IN) inhibitors have successfully passed the early phases of clinical development. By ...
Tópico(s): HIV/AIDS Research and Interventions
2006 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
E.M. Galati, Natalizia Miceli, Clementina Maria Galluzzo, Maria Fernanda Taviano, Olga Tzakou,
Several cyclopentanoid monoterpenes related to the iridoid compounds (nepetalactones) have been isolated and characterized in many Nepeta species. We studied the neuropharmacological activity of Nepeta sibthorpii Bentham essential oil (1.5 mg/kg i.p.), methanol extract (50 mg/kg i.p. and p.o.), and fraction containing epinepetalactone (Fraction I) obtained from methanol extract (dose corresponding to 50 mg/kg of methanol extract i.p. and p.o.) in rodents. N. sibthorpii preparations produced definite ...
Tópico(s): Medicinal Plants and Neuroprotection
2004 - Taylor & Francis | Pharmaceutical Biology
Marco Floridia, Raffaella Bucciardini, Vincenzo Fragola, Clementina Maria Galluzzo, Giacomo Giannini, Maria Franca Pirillo, Roberta Amici, Mauro Andreotti, D. Ricciardulli, Carlo Tomino, Stefano Vella,
Most of the studies evaluating rash in HIV-positive patients have focused on nonnucleoside reverse transcriptase inhibitors (NNRTI), particularly nevirapine, and little is known about the occurrence of rash and the risk factors for its development in patients receiving regimens not based on NNRTI.We evaluated all cases of rash observed during a 48-week randomized multicentre trial in 1251 nucleoside-experienced patients who started treatment with protease inhibitors (ritonavir or indinavir) at CD4 ...
Tópico(s): HIV/AIDS Research and Interventions
2004 - Wiley | HIV Medicine
Annita Pintor, Clementina Maria Galluzzo, Rosa Grieco, Antonella Pèzzola, Rosaria Reggio, Patrizia Popoli,
Abstract Active uptake by neurons and glial cells is the main mechanism for maintaining extracellular glutamate at low, non‐toxic concentrations. Activation of adenosine A 2A receptors increases extracellular glutamate levels, while A 2A receptor antagonists reduce stimulated glutamate outflow. Whether a modulation of the glutamate uptake system is involved in the effects elicited by A 2A receptor blockers has never been investigated. This study examined the ability of adenosine A 2A receptor antagonists ...
Tópico(s): Molecular Sensors and Ion Detection
2004 - Wiley | Journal of Neurochemistry
Loredana Sarmati, Emanuele Nicastri, Ilaria Uccella, Gabriella d’Ettorre, Saverio Giuseppe Parisi, Lucia Palmisano, Clementina Maria Galluzzo, Ercole Concia, Vincenzo Vullo, Stefano Vella, Massimo Andreoni,
ABSTRACT In 32 patients for whom highly active antiretroviral therapy was failing, a good agreement between drug resistance-associated mutations in plasma and peripheral blood mononuclear cells (PBMCs) was found ( k = 0.85). The mutations with the lowest agreement were 20R, 63P, and 84V in the protease gene and 184V in the reverse transcriptase gene. In eight patients, primary drug resistance mutations were detected only in PBMCs.
Tópico(s): HIV/AIDS Research and Interventions
2003 - American Society for Microbiology | Journal of Clinical Microbiology