Malcolm Brown, William Kay, Barbara Hall, John Jay City Editor, Mitchell Cotts, John Davison, Philip Norman, Martin Redfern, Rob Hughes, Dr K Hillard, John Peter, Eric Dymock, Brian Deer Social Affairs Correspondent, John Jay, Neville Hodgkinson Medical Correspondent, Graham Rose, Mark Lawson, John Kerr, Frederic Raphael, Dalbert Hallenstein, Jason Tomas, Mark Hosenball, Henry Porter, Jancis Robinson, John Westwell, Jon Craig, Judi Bevan Deputy City Editor, Patrick Stoddart, Ralph Lauren, Robert Sandall, Irwin Stelzer, John Newell, Robert Hewison, Ivan Fallon, Deryk Brown, Roger Eglin Business News Editor, Keith Botsford, Franco Zeffirelli, Jane Bird, Roux Brothers, Kingsley Amis, John Witherow, Philip Beresford Industrial Editor, Don Simpson, Jane de Wardener, Michael Bryant, David Cairns, Adrianne Blue, David Connett, Carol Price, Mick Cleary, Giles Merritt, Moutet Anne-Elisabeth, Geoff Whitten, Hugh St Clair, Paul Bailey, Christine Toomey, Bernard Cafferty, R Bown, Tana de Zulueta, Jerry Bruckheimer, Tim Gillham President, Nigella Lawson, Boris Schapiro, Patricia Craig, Rose Tremain, Tim Haines, Anne Jacobs Local Government Correspondent, Mazher Mahmood, Brian Jackman, Lesley Dobson, Brian Morris, John Hopkins, Askold Krushelnycky, Liz Jobey, Judi Bevan, Maria Laura, Timothy Mo, Holly Smith, Jonathan Raban, Kazuo Ishiguro, Simon Freeman, Stephen Pile, Steve Ellis, James Wilson, Diana Wright, Christopher Smallwood, James Adams Defence Correspondent, Stephen Jones, Ed Blunt, Richard Evans, Brian Deer, Patricia Davis, Meriel McCooey, Norman Lebrecht, Brian Welden, Tom Zimberoff, Bruce Kemble Education Correspondent, Stephen Davis, T Moore, Dilys Powell, David Skan, Brough Scott, Deyan Sudjic, Norman Stone, David Profumo, Tony Osman, Stuart Alexander, Louise Branson, Richard Woods, David Browne, Simon Winchester, Max Prangnell, Paloma Picasso, Margaret Atwood, Barrie Penrose, David Hughes Political Correspondent, Igor Aleksander, Tim Blackstone, Michael Jones Political Editor, Philip Beresford, Godfrey Smith, Stephen Dorrell, James Truman, Annabel Walker, Charles Oulton, David Parsons, Brian Clarke, Brian Glanville, John Carey, Dr John Havard Secretary British Medical Association, David Sinclair, Tony Urquhart, Peter Gold, Bob Brunning, Rowena Webster, Marie Colvin Tyre, Douglas Lovelock, Minette Marrin, Simon Rose, Peter Jenkins, Marina Vaizey, Margaret Park, Robertson Davies, Penny Perrick, Jim Belushi, Tony Hetherington, Peter Roebuck, Roger Ratcliffe, Jon Connell, Leslie Geddes-Brown, Georgina Howell,
... check The Sunday Times Nun Run: Sister Mary Perpetua, 72,… Teacher pay deal is set to collapse ...
1986 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Thais P. Pivetta, Letícia B. Silva, Camila Martins Kawakami, Margarete Moreno de Araújo, Maria Perpétua F.M. Del Lama, Rose Mary Zumstein Georgetto Naal, Silvya Stuchi Maria‐Engler, Lorena Rigo Gaspar, Priscyla D. Marcato,
Skin aging might happen due to extrinsic and intrinsic factors that usually can induce the increase of free radicals and generate oxidative stress, which lead to skin alterations. Thus, there is a search for antioxidant substances that can control these effects. Quercetin (QT) is a flavonoid with antioxidant potential however presents poor percutaneous permeation, low stability and phototoxicity. Therefore, the encapsulation in nanoparticles is an interesting strategy to overcome these challenges. ...
Tópico(s): Olfactory and Sensory Function Studies
2019 - Elsevier BV | Journal of Drug Delivery Science and Technology
Produção Nacional
Revisado por pares
Daniela A. Cunha, Leonardo Bartkevihi, Julia de Macedo Robert, Eliane Pereira Cipolatti, André Ferreira, Danielle Maria Perpétua de Oliveira, Francisco Gomes‐Neto, Rodrigo Volcan Almeida, Roberto Fernandéz‐Lafuente, Denise Maria Guimarães Freire, Cristiane Dinis Anobom,
Lipase B from Candida antarctica (CalB) is the most widely used lipase, including in many industrial sectors, such as in biodiesel and pharmaceuticals production. CalB has been produced by heterologous expression using Pichia pastoris under PGK constitutive promoter (named LipB). Here, we have studied the structural features of commercial CalB and LipB enzymes using circular dichroism and fluorescence under different conditions. In the presence of denaturing agents CalB was more stable than LipB, ...
Tópico(s): Photosynthetic Processes and Mechanisms
2019 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Valdemir da Costa Silva, Abiane M. G. S. Silva, Jacqueline Arantes Diniz Basílio, Jadriane A. Xavier, Ticiano Gomes do Nascimento, Rose Mary Zumstein Georgetto Naal, Maria Perpetua del Lama, Laila A. D. Leonelo, Naianny Lívia Oliveira Nascimento Mergulhão, Fernanda Cristina de Albuquerque Maranhão, Denise Maria Wanderlei Silva, Robert W. Owen, I. Rodrigues, Laisa Carolina Gomes de Bulhões, Irinaldo Diniz Basílio Júnior, Marília Oliveira Fonseca Goulart,
The main objectives of this study were to evaluate the chemical constitution and allergenic potential of red propolis extract (RPE). They were evaluated, using high performance liquid chromatography (HPLC) and the release of β-hexosaminidase, respectively. A plethora of biologically active polyphenols and the absence of allergic responses were evinced. RPE inhibited the release of β-hexosaminidase, suggesting that the extract does not stimulate allergic responses. Additionally, the physicochemical ...
Tópico(s): Microencapsulation and Drying Processes
2020 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Luciane Macedo de Menezes, Maria Perpétua Mota Freitas, Tatiana Siqueira Gonçalves,
O objetivo deste trabalho é apresentar uma revisão sobre os conceitos relacionados à biocompatibilidade dos materiais empregados em Ortodontia. Fatos relacionados às reações de hipersensibilidade aos diversos materiais ortodônticos são discutidos, sendo apresentadas as condutas recomendáveis nestas situações.
Tópico(s): Endodontics and Root Canal Treatments
2009 - Dental Press Editora | Revista Dental Press de Ortodontia e Ortopedia Facial
Produção Nacional
Revisado por pares
Maria Perpétua Mota Freitas, Hugo Mitsuo Silva Oshima, Luciane Macedo de Menezes, Denise Cantarelli Machado, Christian Viezzer,
Abstract Objective: To test the null hypothesis that the silver soldering employed in orthodontics is not cytotoxic for fibroblasts. Materials and Methods: This in vitro study was performed using a culture of mice fibroblasts (lineage NIH/3T3), divided into four groups (n = 10 each): control, negative control (stainless steel archwire), positive control (amalgam disks), and test group (silver soldering). After cell culture in complete Dulbecco modified eagle medium and achievement of confluence in 80%, ...
Tópico(s): Marine Biology and Environmental Chemistry
2009 - E.H Angle Education and Research Foundation | The Angle Orthodontist
Produção Nacional
Revisado por pares
Fabio M. Gomes, Danielle Maria Perpétua de Oliveira, Lucimar S. Motta, Isabela Ramos, Kildare Miranda, Ednildo A. Machado,
Abstract Inorganic polyphosphate (poly P) is a polymer of phosphate residues that has been shown to act as modulator of some vertebrate cathepsins. In the egg yolk granules of Rhodnius prolixus , a cathepsin D is the main protease involved in yolk mobilization and is dependent on an activation by acid phosphatases. In this study, we showed a possible role of poly P stored inside yolk granules on the inhibition of cathepsin D and arrest of yolk mobilization during early embryogenesis of these insects. ...
Tópico(s): Protease and Inhibitor Mechanisms
2009 - Wiley | Journal of Cellular Physiology
Produção Nacional
Marcio Fontenele, K. Carneiro, Rodrigo A. Agrellos, Danielle Maria Perpétua de Oliveira, A. Oliveira-Silva, Viviane Cristina Vieira, Érika Negreiros, Ednildo A. Machado, Helena Araujo,
Regulation of NFκB activity is central to many processes during development and disease. Activation of NFκB family members depends on degradation of inhibitory IκB proteins. In Drosophila, a nuclear gradient of the NFκB/c-rel protein Dorsal subdivides the embryonic dorsal–ventral axis, defining the extent and location of mesodermal and ectodermal territories. Activation of the Toll pathway directs Dorsal nuclear translocation by inducing proteosomal degradation of the IκB homologue Cactus. Another ...
Tópico(s): NF-κB Signaling Pathways
2009 - Elsevier BV | Mechanisms of Development
Produção Nacional
Revisado por pares
Marcelo Neves de Medeiros, Danielle Maria Perpétua de Oliveira, Gabriela O. Paiva‐Silva, Mário A.C. Silva-Neto, Alexandre Romeiro, Marcelo T. Bozza, Hatisaburo Masuda, Ednildo A. Machado,
The participation of eicosanoids and second messengers on the regulation of RHBP endocytosis by the ovaries was investigated, using [125I]RHBP in experiments in vivo and in vitro. Addition of PGE2 (one of the products of the cyclooxygenase pathway) decreased in vitro the uptake of RHBP by 35%. The rate of RHBP endocytosis increased in the presence of indomethacin, a potent cyclooxigenase inhibitor, up to 50% in vitro and up to 55% in vivo, thus giving support to the role of cyclooxygenase derivatives ...
Tópico(s): Protein Structure and Dynamics
2002 - Elsevier BV | Insect Biochemistry and Molecular Biology
Produção Nacional
Revisado por pares
Marı́lia Gama Sauaia, Elia Tfouni, R.H.A. Santos, Maria Teresa do Prado Gambardella, Maria Perpétua F.M. Del Lama, Luiz Fernando Lopes Guimarães, Roberto Santana da Silva,
Tópico(s): Molecular Sensors and Ion Detection
2003 - Elsevier BV | Inorganic Chemistry Communications
Produção Nacional
Revisado por pares
Lucimar S. Motta, Wagner Seixas da‐Silva, Danielle Maria Perpétua de Oliveira, Wanderley de Souza, Ednildo A. Machado,
The H+-PPase activity was characterized in membrane fractions of ovary and eggs of Rhodnius prolixus. This activity is totally dependent on Mg2+, independent of K+ and strongly inhibited by NaF, IDP and Ca2+. The membrane proteins of eggs were analyzed by western blot using antibodies to the H+-PPase from Arabidopsis thaliana. The immunostain was associated with a single 65-kDa polypeptide. This polypeptide was immunolocalized in yolk granule membranes by optical and transmission electron microscopy. ...
Tópico(s): Electron Spin Resonance Studies
2003 - Elsevier BV | Insect Biochemistry and Molecular Biology
Produção Nacional
Revisado por pares
Pierina Sueli Bonato, Maria Perpétua F.M. Del Lama, Roberto de Carvalho,
The enantioselective analysis of ibuprofen (IBU), a chiral nonsteroidal anti-inflammatory drug, in human plasma was carried out by high-performance liquid chromatography (HPLC)–mass spectrometry (LC–MS–MS). The plasma samples were prepared by liquid–liquid extraction using hexane:ethyl acetate (8:2, v/v). The HPLC chiral resolution of IBU was obtained using a chiral stationary phase based on a tris-(3,5-dimethylphenylcarbamate) amylose derivative, under reversed phase conditions (CHIRALPAK AD-RH column), ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2003 - Elsevier BV | Journal of Chromatography B
Produção Nacional
Revisado por pares
Danielle Maria Perpétua de Oliveira, Isabela Ramos, Flavia C. G. Reis, Ana Paula C. A. Lima, Ednildo A. Machado,
In this work, we characterized the activities of two classes of proteases and AcP during early embryogenesis of Periplaneta americana. AcP activity was first detected at day 6 and reached a maximum level at day 10 of development. Using phosphoamino acids, phosphatase activity was shown to be directed only against phosphotyrosine at day 6 while at day 10 it was also active against phosphoserine. In parallel, two classes of proteases were detected and located within yolk granules: a clan CA-cysteine ...
Tópico(s): Phytase and its Applications
2008 - Elsevier BV | Journal of Insect Physiology
Produção Nacional
Revisado por pares
Maria Perpétua Mota Freitas, H. Ōshima, Luciane Macedo de Menezes,
The objective of this study was to test the hypothesis that toxic metallic ions in silver solder used in orthodontics are released into saliva.The sample included 60 children, 8 to 14 years of age, divided into 2 groups (n = 30 in each group): the control group and the study group (needing maxillary expansion with the hyrax appliance). For analysis of the release of metallic ions, saliva samples from each patient were collected at 6 times in both groups: before placement of the appliance and 10 minutes, ...
Tópico(s): Facial Trauma and Fracture Management
2011 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
Produção Nacional
Revisado por pares
Marcelo Neves de Medeiros, Isabela Ramos, Danielle Maria Perpétua de Oliveira, Rodrigo C.B. da Silva, Fabio M. Gomes, Luciano Neves de Medeiros, Eleonora Kurtenbach, Luciana B. Chiarini, Hatisaburo Masuda, Wanderley de Souza, Ednildo A. Machado,
In this work we characterized the degenerative process of ovarian follicles of the bug Rhodnius prolixus challenged with the non-entomopathogenic fungus Aspergillus niger. An injection of A. niger conidia directly into the hemocoel of adult R. prolixus females at the onset of vitellogenesis caused no effect on host lifespan but elicited a net reduction in egg batch size. Direct inspection of ovaries from the mycosed insects revealed that fungal challenge led to atresia of the vitellogenic follicles. ...
Tópico(s): Neurobiology and Insect Physiology Research
2011 - Elsevier BV | Journal of Insect Physiology
Produção Nacional
Revisado por pares
Isabela Ramos, Kildare Miranda, Wanderley de Souza, Danielle Maria Perpétua de Oliveira, Ana Paula C. A. Lima, Marcos Henrique Ferreira Sorgine, Ednildo A. Machado,
SUMMARY This study examined the process of membrane fusion of yolk granules (YGs)during early embryogenesis of Rhodnius prolixus. We show that eggs collected at days 0 and 3 after oviposition contain different populations of YGs, for example day-3 eggs are enriched in large YGs (LYGs). Day-3 eggs also contain the highest free [Ca2+] during early embryogenesis of this insect. In vitro incubations of day-0 YGs with [Ca2+]similar to those found in day-3 eggs resulted in the formation of LYGs, as observed ...
Tópico(s): Trypanosoma species research and implications
2006 - The Company of Biologists | Journal of Experimental Biology
Produção Nacional
Revisado por pares
Eloi Feitosa, Marcelo Rodrigo Savério Brazolin, Rose Mary Zumstein Georgetto Naal, Maria Perpétua Freire de Morais Del Lama, Josias R. Lopes, Watson Loh, Marilena Vasilescu,
We used dynamic light scattering (DLS), steady-state fluorescence, time resolved fluorescence quenching (TRFQ), tensiometry, conductimetry, and isothermal titration calorimetry (ITC) to investigate the self-assembly of the cationic surfactant cetyltrimethylammonium sulfate (CTAS) in aqueous solution, which has SO(2-)4 as divalent counterion. We obtained the critical micelle concentration (cmc), aggregation number (N(agg)), area per monomer (a0), hydrodynamic radius (R(H)), and degree of counterion dissociation ( ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
2006 - Elsevier BV | Journal of Colloid and Interface Science
Produção Nacional
Revisado por pares
Luciana Borges Retamoso, Tatiana Blaya Luz, Daniel Rodrigo Marinowic, Denise Cantarelli Machado, Luciane Macedo de Menezes, Maria Perpétua Mota Freitas, Hugo Mitsuo Silva Oshima,
Introduction In this study, we evaluated the cellular viability of various esthetic, metallic, and nickel-free orthodontic brackets. Methods The sample was divided into 11 groups (n = 8): cellular control, negative control, positive control, metallic, polycarbonate, 2 types of monocrystalline ceramic, 3 types of nickel free, and polycrystalline ceramic brackets. Cell culture (NIH/3T3-mice fibroblasts) was added to the plates of 96 wells containing the specimens and incubated in 5% carbon dioxide at ...
Tópico(s): 3D Printing in Biomedical Research
2012 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
Produção Nacional
Revisado por pares
Marcela de Souza Santos, Willian Jonis Andrioli, Maria Perpétua Freire de Morais Del Lama, Jairo Kenupp Bastos, N. P. Dhammika Nanayakkara, Rose Mary Zumstein Georgetto Naal,
Mast cells play a critical role during the development of an allergic response. Upon activation by an antigen and IgE, via FcεRI receptors, mast cells release histamine and other mediators that initiate and propagate immediate hypersensitivity reactions. Mast cells also secrete cytokines that regulate the immune responses. In this way, inhibitors of mast cell activity could work as promising therapeutics for allergic disorders. In the present work, we investigated the capacity of pyridovericin, ...
Tópico(s): Allergic Rhinitis and Sensitization
2013 - Elsevier BV | International Immunopharmacology
Produção Nacional
Revisado por pares
Marcela de Souza Santos, Maria Perpétua Freire de Morais Del Lama, Amando Siuiti Ito, Rose Mary Zumstein Georgetto Naal,
The pharmacological action of chloroquine relies on its ability to cross biological membranes in order to accumulate inside lysosomes. The present work aimed at understanding the basis for the interaction between different chloroquine species and ionic micelles of opposite charges, the latter used as a simple membrane model. The sensitivity of absorbance and fluorescence of chloroquine to changes in its local environment was used to probe its interaction with cetyltrimethylammonium micelles presenting ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2013 - Elsevier BV | Journal of Luminescence
Produção Nacional
Revisado por pares
Marcela de Souza Santos, Maria Perpétua Freire de Morais Del Lama, Laila Aparecida Deliberto, Flávio da Silva Emery, Mônica Tallarico Pupo, Rose Mary Zumstein Georgetto Naal,
Tópico(s): Plant chemical constituents analysis
2013 - Springer Nature | Archives of Pharmacal Research
Produção Nacional
Revisado por pares
Marcio Fontenele, Bomyi Lim, Danielle Maria Perpétua de Oliveira, Márcio Buffolo, Hyun Joo An, Trudi Schüpbach, Helena Araujo,
Calcium-dependent cysteine proteases of the calpain family are modulatory proteases that cleave their substrates in a limited manner. Among their substrates, calpains target vertebrate and invertebrate IκB proteins. Because proteolysis by calpains potentially generates novel protein functions, it is important to understand how this affects NFκB activity. We investigate the action of Calpain A (CalpA) on the Drosophila melanogaster IκB homologue Cactus in vivo. CalpA alters the absolute amounts of ...
Tópico(s): Neurobiology and Insect Physiology Research
2013 - American Society for Cell Biology | Molecular Biology of the Cell
Produção Nacional
Revisado por pares
Guilherme Thiesen, Bruno Frazāo Gribel, Maria Perpétua Mota Freitas,
Abstract The term "asymmetry" is used to make reference to dissimilarity between homologous elements, altering the balance between structures. Facial asymmetry is common in the overall population and is often presented subclinically. Nevertheless, on occasion, significant facial asymmetry results not only in functional, but also esthetic issues. Under these conditions, its etiology should be carefully investigated in order to achieve an adequate treatment plan. Facial asymmetry assessment comprises ...
Tópico(s): dental development and anomalies
2015 - Dental Press Editora | Dental Press Journal of Orthodontics
Produção Nacional
Revisado por pares
Danilo L. Menaldo, Carolina P. Bernardes, Karina Furlani Zoccal, Anna L. Jacob‐Ferreira, Tássia R. Costa, Maria Perpétua F.M. Del Lama, Rose Mary Zumstein Georgetto Naal, Fabiani Gai Frantz, Lúcia Helena Faccioli, Suely Vilela Sampaio,
Bothrops envenomations can promote severe inflammatory responses by inducing edema, pain, leukocyte recruitment and release of chemical mediators by local cells. In the present study, two toxins from Bothrops atrox venom (the P-I metalloprotease Batroxase and the acidic phospholipase A2 BatroxPLA2) were evaluated in relation to their inflammatory effects induced in vivo and in vitro, mainly focusing on the participation of different immune cells and inflammatory mediators. Both toxins mainly promoted ...
Tópico(s): Pain Mechanisms and Treatments
2017 - Elsevier BV | Molecular Immunology
Produção Nacional
Revisado por pares
Guilherme Thiesen, Bruno Frazāo Gribel, Ki Beom Kim, Keila Cristina Rausch Pereira, Maria Perpétua Mota Freitas,
Background: This study aimed to estimate the prevalence of mandibular asymmetry and investigate some associated factors. Methods: Tomographic images of 952 individuals aged from 18 to 75 years old were analyzed. The investigated outcome was mandibular asymmetry. The explanatory variables included gender, age, absence of posterior teeth, and sagittal jaw relationship of the individuals. Statistical analyses included the chi-squared and the Poisson regression with robust variance. Results: Mandibular ...
Tópico(s): Dental Radiography and Imaging
2017 - Lippincott Williams & Wilkins | Journal of Craniofacial Surgery
Produção Nacional
Revisado por pares
Paulo Floriani Kramer, Luciana Melo Pereira, Mariana Cézar Ilha, Tássia Silvana Borges, Maria Perpétua Mota Freitas, Carlos Alberto Feldens,
ABSTRACT Objective: To investigate the association between malocclusion/dentofacial anomalies and traumatic dental injuries (TDI) in adolescents. Materials and Methods: The sample of this cross-sectional study comprised 509 adolescents aged 11 to 14 years enrolled at public schools in the city of Osório, southern Brazil. Parents answered a structured questionnaire addressing demographic and socioeconomic characteristics. An examiner who had undergone a training and calibration exercise recorded malocclusion/ ...
Tópico(s): dental development and anomalies
2017 - E.H Angle Education and Research Foundation | The Angle Orthodontist
Produção Nacional
Revisado por pares
Guilherme Thiesen, Maria Perpétua Mota Freitas, Eustáquio A. Araújo, Bruno Frazāo Gribel, Ki Beom Kim,
Introduction Our objective was to analyze the characteristics that affect skeletal Class I adults with mandibular asymmetries using cone-beam computerized tomography. Methods The sample included cone-beam computerized tomography images of 120 subjects. Asymmetry was determined by the deviation of gnathion from the midsagittal plane and classified as relative symmetry, moderate asymmetry, or severe asymmetry. Maxillary and mandibular measurements were made, and the differences between the contralateral side ...
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2018 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
Produção Nacional
Revisado por pares
Guilherme Thiesen, Bruno Frazāo Gribel, Maria Perpétua Mota Freitas, D.R. Oliver, Ki Beom Kim,
ABSTRACT Objectives: To estimate the prevalence of mandibular asymmetries in orthodontic and orthognathic surgery patients and to investigate demographic and skeletal factors associated with this disharmony. Materials and Methods: Cone-beam computed tomography images of 1178 individuals aged 19 through 60 years with complete dentitions were analyzed. Outcomes were classified as relative mandibular symmetry, moderate asymmetry, and severe asymmetry. Factors recorded included sex, age, side of mandibular ...
Tópico(s): Facial Trauma and Fracture Management
2018 - E.H Angle Education and Research Foundation | The Angle Orthodontist
Produção Nacional
Revisado por pares
Andreza R. Garcia, Danielle Maria Perpétua de Oliveira, Ana Cláudia F. Amaral, Jéssica B. de Jesus, Ana Carolina Rennó Sodero, Alessandra Mendonça Teles de Souza, Claudiu T. Supuran, Alane Beatriz Vermelho, Igor A. Rodrigues, Anderson S. Pinheiro,
Inhibition of Leishmania arginase leads to a decrease in parasite growth and infectivity and thus represents an attractive therapeutic strategy. We evaluated the inhibitory potential of selected naturally occurring phenolic substances on Leishmania infantum arginase (ARGLi) and investigated their antileishmanial activity in vivo. ARGLi exhibited a Vmax of 0.28 ± 0.016 mM/min and a Km of 5.1 ± 1.1 mM for L-arginine. The phenylpropanoids rosmarinic acid and caffeic acid (100 µM) showed percentages of inhibition ...
Tópico(s): Trypanosoma species research and implications
2019 - Taylor & Francis | Journal of Enzyme Inhibition and Medicinal Chemistry
Produção Nacional
Revisado por pares
Maria Perpétua do Socorro Beserra Soares,
O presente artigo apresenta os resultados de uma pesquisa acerca da formação continuada de professores dos anos iniciais do Ensino Fundamental em uma escola da rede pública da cidade de São Paulo - SP e o objetivo geral é analisar os alcances e limites da formação continuada de professores para a prática pedagógica comprometida com a construção de uma escola democrática. O aporte teórico fundamenta-se na Pedagogia de Paulo Freire (2001, 2013a, 2015 e 2016), Imbernón (2009, 2010) e Saul (2010). A investigação ...
Tópico(s): Rural and Ethnic Education
2019 - UNIVERSIDADE ESTADUAL DO CEARÁ | Educação & Formação