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Artigo Acesso aberto Revisado por pares

Antón Barreiro‐Iglesias, Daniel Sobrido‐Cameán, Marı́a Celina Rodicio,

... Isabel Rodríguez-Moldes, José Manuel López, Juan José Pita, María E. Cameán, Jesús Torres, José Pumares, Verónica Rodríguez, ...

Tópico(s): Traumatic Brain Injury Research

2018 - Medknow | Neural Regeneration Research

Artigo Acesso aberto Revisado por pares

Antón Barreiro‐Iglesias, Daniel Romaus‐Sanjurjo, Marı́a Celina Rodicio,

... Isabel Rodríguez-Moldes, José Manuel López, Juan José Pita, María E. Cameán, Jesús Torres, José Pumares, Verónica Rodríguez, ...

Tópico(s): Neuroendocrine regulation and behavior

2019 - Medknow | Neural Regeneration Research

Artigo Revisado por pares

Florencia Corbelle,

Tópico(s): Latin American Literature Studies

2010 - University of Buenos Aires | Cuadernos de antropología social

Jornais Acesso aberto

Srikumar Sen, Boxing Correspondent, Peter Brookes, Clifford Longley, Andrew Billen, Patricia Davies, William Stephens, Jane MacQuitty, Simon Barnes, Richard Thomson Banking Correspondent, Paul Bompard, David Miller Chief Sports Correspondent, Mark Souster, Ronald Faux, David Rhys Jones, Tom Pocock, Ivo Tennant, Desmond Douglas, Michael Seely, Racing Correspondent, Ian Murray, Andrea Adams, Michael Binyon, Jeremy Kingston, Jeremy Flint, Yvonne Thomas, Anthony Evans, Colin Narbrough, Gerald Davies, Joe Joseph, Howard Foster, Francesca Greenoak, Michael Fisher, Henry Gee, DTI, Peter Davenport, Peter Ball, Richard Ford Political Correspondent, John Hungerford, Louise Taylor, Lawrence Lever, Rodney Cowton, Transport Correspondent, Roland Rudd Employment Affairs Reporter, Mick Cleary, Meghnad Desai, Martin Andrew, W. H. Weston-Davies, Michael Evans, Defence Correspondent, Robin Young, Rosemary Unsworth, D. A. Hearn, Rawlinson, Michael Clark, Martin Fletcher, Political Reporter, John Young, John Dorman, Frances Bissell, David Hands, Charles Bremner, J. P. Crowther, R. Hugh MacDougall, Richard Thomson, Banking Correspondent, Conor Cruise O'Brien, Neil Wright, Jane Rackham, George Rae, Rex Bellamy Tennis Correspondent, Paul Vallely, Wolfgang Munchau, Sydney Friskin, Barry Millington, Mitchell Platts Golf Correspondent, (Michael Phillips), Celia Brayfield, John Higgins, Christopher Goulding, Kerry Gill, Raymond Keene, D. R. C. Jonas, Emma Wilkins, Barbara Amiel, A. C. Rose-Innes, Paul Griffiths, Peter Bryan, Alexandra Jackson, Richard Evans, John Eventt, Martin Trew, John Blunsden, John Holland, Barry Pickthall, Pat Butcher, Peter Brimelow, Richard Bassett, Keith MacKlin, Michael S. Darby, Deyan Sudjic, David Brewerton, Mr. L. F. Flint, Sarah Jane Art Market Correspondent, George Ace, John Goodbody, Ian Smith, Thomas Willesden, Peter Aykroyd, Sam Kiley, Higher Education Reporter, Graham Searjeant, Financial Editor, Clive White, Paul Newman, K. C. Bass, Jonathan Rendall, Michael Seely, Susannah Herbert, Peter Dear, G. H. Turner, Sarah Jane Checkland, P. D., Thomson Prentice and Martin Fletcher, David Sinclair, Martin Waller, Tom Tickell, Sarah Jane, Jonathan Meades, David Tytler, Education Editor, Pat Butcher Athletics Correspondent, Richard Morrison, Sam Kiley, Anne McElvoy, Kensington Palace, Maria Scott, Richard Ford, Political Correspondent, Naim Attallah, Alec Cairncross, Tony Hetherington, Conal Gregory, Shona Crawford Poole, Judy Froshaug, Kenneth Flett, David Hands, Rugby Correspondent, A. Graham Hellier, Richard Williams,

... heal the chores Wine Buys Brandy Asbach Uralt PITA Multiple Display Advertising Items Entertainments Multiple Display Advertising ...

1988 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

T. Ventura, Manuel C. Gomes, Ana María Simón Pita, Maria Teresa Neto, Alyx Taylor,

The 2D:4D digit ratio is sexually-dimorphic, probably due to testosterone action through the perinatal period. We characterize the 2D:4D ratio in newborn (NB) infants, in between the pre- and postnatal surges of testosterone, and relate it to the mother's 2D:4D and to testosterone levels in the amniotic fluid (AF). Testosterone was assayed in samples of maternal plasma and AF collected at amniocentesis. Shortly after birth, 106 NBs and their mothers were measured for 2D:4D ratio. NB males had lower ...

Tópico(s): Urological Disorders and Treatments

2012 - Elsevier BV | Early Human Development

Artigo Acesso aberto Revisado por pares

Mauro Federico Andreu, María Eugenia Dotta, Marco Bezzi, Silvina Borello, Gimena Paola Cardoso, Paula C Dib, Silvina L García Schustereder, Alejandra M Galloli, Daniela Rocío Castro, Victoria L Di Giorgio, Federico J Villalba, Matías Nicolás Bertozzi, Juan Manuel Carballo, M.C. Martín Delgado, Carla Candela Brovia, María C Pita, María P Pedace, María F De Benedetto, Julieta Delli Carpini, Patricio Aguirre, Gisela Montero,

BACKGROUND: Laboratory studies suggest applying positive pressure without endotracheal suction during cuff deflation and extubation. Although some studies reported better physiological outcomes (e.g. arterial blood gases) with this technique, the safety of positive pressure extubation technique has not been well studied. The aim of this study was to determine the safety of the positive-pressure extubation technique compared with the traditional extubation technique in terms of incidence of complications. METHODS: ...

Tópico(s): Cardiac Arrest and Resuscitation

2019 - American Association for Respiratory Care | Respiratory Care

Artigo Acesso aberto Revisado por pares

Laura Remacha, María Currás-Freixes, Raúl Torres, Francesca Schiavi, Rafael Torres‐Pérez, Bruna Calsina, Rocío Letón, Iñaki Comino‐Méndez, Juan María Roldán‐Romero, Cristina Montero‐Conde, María Santos, Lucía Inglada‐Pérez, Guillermo Pita, María R. Alonso, Emiliano Honrado, Susana Pedrinaci, Benedicto Crespo‐Facorro, Antonio Percesepe, Maurizio Falcioni, Sandra Rodríguez, Esther Korpershoek, Santiago Ramón‐Maiques, Giuseppe Opocher, Cristina Rodríguez‐Antona, Mercedes Robledo, Alberto Cascón,

The high percentage of patients carrying germline mutations makes pheochromocytomas/paragangliomas the most heritable of all tumors. However, there are still cases unexplained by mutations in the known genes. We aimed to identify the genetic cause of disease in patients strongly suspected of having hereditary tumors.Whole-exome sequencing was applied to the germlines of a parent-proband trio. Genome-wide methylome analysis, RNA-seq, CRISPR/Cas9 gene editing, and targeted sequencing were also performed. ...

Tópico(s): Glioma Diagnosis and Treatment

2018 - Elsevier BV | Genetics in Medicine

Artigo Acesso aberto Revisado por pares

Juan Corredoira-Sánchez, Fernando Garcı́a-Garrote, Ramón Rabuñal Rey, Leopoldo López-Rosés, Ma José García-Pais, Esmeralda Gracián-Castro, R. Gonzalez-Soler, Amparo Coira, J. Pita, María López-Álvarez, Marı́a Pilar Alonso, J. Varela,

Background. The association between bacteremia by Streptococcus gallolyticus subsp. gallolyticus (SGG) and colorectal neoplasia (CRN) is well established but the frequency of the association varies widely in different studies. We conducted a case-control study to assess the association between SGG bacteremia and CRN.

Tópico(s): Colorectal Cancer Screening and Detection

2012 - Oxford University Press | Clinical Infectious Diseases

Artigo Acesso aberto Revisado por pares

C. DeLucchi, M.L. Pita, María José Faus, J. A. Molina, Ricardo Uauy, Ángel Gil,

Human milk contains relatively high amounts of acid-soluble nucleotides, mainly CMP, AMP. UMP. IMP, and UDP sugars, and lacks orotate. On the contrary, cow's milk and adapted formulas contain high amounts of orotate and very low amounts of CMP and AMP. Nucleotides may he modulators of metabolic functions in gut and liver. To evaluate the possible role of dietary nucleotides in newborn fatty acid metabolism, we studied the polyunsaturated fatty acid (PUFA) composition of erythrocyte membrane phospholipids ...

Tópico(s): Fatty Acid Research and Health

1987 - Lippincott Williams & Wilkins | Journal of Pediatric Gastroenterology and Nutrition

Artigo Acesso aberto Revisado por pares

M.L. Pita, María Reyes Pérez Fernández, C. DeLucchi, Antonio Medina, Antonio Martínez‐Valverde, Ricardo Uauy, Ángel Gil,

Summary: The fatty acid profile of red blood cell phospholipids and the total phospholipid and cholesterol contents of erythrocyte membrane in preterm infants in the first month of life were studied. Influences of human milk and adapted formula and dietary nucleotides supplementation at a level similar to that found in human milk were evaluated. Nineteen preterm newborn infants with adequate weight for gestational age were fed their own mother's preterm human milk, 18 with a standard milk formula ...

Tópico(s): Neonatal Health and Biochemistry

1988 - Lippincott Williams & Wilkins | Journal of Pediatric Gastroenterology and Nutrition

Artigo Revisado por pares

C. DeLucchi, M.L. Pita, María José Faus, J.L. Periago, Ángel Gil,

The fatty acid and cholesterol contents of tissue membranes are determinants of their stability and functionality. This study was designed to evaluate the influences of diet and postnatal age on the polyunsaturated fatty acid (PUFA) composition of erythrocyte membrane phospholipid fractions and on the red blood cell membrane cholesterol and phosphorus contents in newborn infants during the 1st month of life. A group of infants was fed on human milk and another group on adapted milk formula. Blood ...

Tópico(s): Neonatal and fetal brain pathology

1988 - Karger Publishers | Annals of Nutrition and Metabolism

Artigo

Susana Mellor‐Pita, María Jesús Citores, Raquel Castejón, M. Yebra‐Bango, Pablo Tutor‐Ureta, Silvia Rosado, José Luís Andreu, Juan A. Vargas,

To investigate the contribution of T lymphocytes and monocytes to cytokine production in systemic lupus erythematosus (SLE).Forty-five SLE patients and 19 healthy volunteers were included. Serum levels of tumor necrosis factor alpha (TNFalpha), interferon gamma (IFN gamma), interleukin (IL)-6, and IL10 were quantified by ELISA. The cytokine production capacities of peripheral blood mononuclear cells were assessed by culturing in vitro with PMA+Ionomycin or LPS. The intracellular cytokine expression ...

Tópico(s): Immune Cell Function and Interaction

2009 - Wiley | Cytometry Part B Clinical Cytometry

Artigo Acesso aberto Revisado por pares

Adriana Gama-Teixeira, Maria Regina Lorenzeti Simionato, Silvia Nagib Elian, Maria Ângela Pita Sobral, Maria Aparecida Alves de Cerqueira Luz,

The aim of this study was to define, in vitro, the potential to inhibit secondary caries of restorative materials currently used in dental practice. Standard cavities were prepared on the buccal and lingual surfaces of fifty extracted human third molars. The teeth were randomly divided into five groups, each one restored with one of the following materials: glass ionomer cement (GIC); amalgam; light-cured composite resin; ion-releasing composite; and light-cured, fluoride-containing composite resin. ...

Tópico(s): Oral microbiology and periodontitis research

2007 - Brazilian Society of Dental Research | Brazilian Oral Research

Revisão Revisado por pares

M. Fernández Castro, Susana Mellor‐Pita, María Jesús Citores, Pilar Muñoz, Pablo Tutor‐Ureta, Lúcia de Fátima da Silva, Juan A. Vargas, M. Yebra‐Bango, José Luís Andreu,

The development of common variable immunodeficiency (CVID) or hypogammaglobulinemia in systemic lupus erythematosus (SLE) is rare. The purpose of this article is to provide a detailed review of lupus-associated CVID and to identify clinical characteristics and laboratory features in patients with SLE-associated CVID.We describe 2 patients with SLE and CVID and review the cases published in the English literature highlighting both the demographic and the clinical characteristics and the laboratory ...

Tópico(s): Chronic Lymphocytic Leukemia Research

2007 - Elsevier BV | Seminars in Arthritis and Rheumatism

Artigo Revisado por pares

Sílvia O. Diaz, Joana Pinto, Gonçalo Graça, Iola F. Duarte, António S. Barros, Eulália Galhano, Cristina Pita, Maria do Céu Almeida, Brian J. Goodfellow, Isabel M. Carreira, Ana M. Gil,

This work describes an exploratory NMR metabonomic study of second trimester maternal urine and plasma, in an attempt to characterize the metabolic changes underlying prenatal disorders and identify possible early biomarkers. Fetal malformations have the strongest metabolic impact in both biofluids, suggesting effects due to hypoxia (leading to hypoxanthine increased excretion) and a need for enhanced gluconeogenesis, with higher ketone bodies (acetone and 3-hydroxybutyric acid) production and TCA ...

Tópico(s): Gestational Diabetes Research and Management

2011 - American Chemical Society | Journal of Proteome Research

Artigo Revisado por pares

Gonçalo Graça, Ana S. P. Moreira, Ana João V. Correia, Brian J. Goodfellow, António S. Barros, Iola F. Duarte, Isabel M. Carreira, Eulália Galhano, Cristina Pita, Maria do Céu Almeida, Ana M. Gil,

This work describes a mid-infrared (MIR) metabolic profiling study of 2nd trimester amniotic fluid in relation to selected prenatal disorders, with results focusing on fetal malformations (FM), preterm delivery (PTD) and premature rupture of membranes (PROM), the latter two conditions occurring later in pregnancy. Partial least squares-discriminant analysis (PLS-DA) models were obtained for FM and pre-PTD subject groups, supported by Monte Carlo Cross Validation (MCCV), and identified specific MIR profile ...

Tópico(s): Metabolomics and Mass Spectrometry Studies

2012 - Elsevier BV | Analytica Chimica Acta

Artigo Revisado por pares

Sílvia O. Diaz, António S. Barros, Brian J. Goodfellow, Iola F. Duarte, Isabel M. Carreira, Eulália Galhano, Cristina Pita, Maria do Céu Almeida, Ana M. Gil,

In this work, untargeted NMR metabonomics was employed to evaluate the effects of pregnancy on the metabolite composition of maternal urine, thus establishing a control excretory trajectory for healthy pregnancies. Urine was collected for independent groups of healthy nonpregnant and pregnant women (in first, second, third trimesters) and multivariate analysis performed on the corresponding NMR spectra. Models were validated through Monte Carlo Cross Validation and permutation tests and metabolite ...

Tópico(s): Folate and B Vitamins Research

2012 - American Chemical Society | Journal of Proteome Research

Artigo Acesso aberto Revisado por pares

Geneviève Verdo,

Apres le succes de l’Histoire des Femmes en Occident, publiee a Buenos Aires en 1993, ces deux volumes presentent une synthese des travaux sur l’histoire des femmes et du genre developpes en Argentine au cours des annees 1990. Les 25 contributions abordent des thematiques diverses, allant du XVIIe au XXe siecle, organisees en trois rubriques. La premiere d’entre elles, « Enfermements et sujetions », analyse la place et la situation des femmes dans divers contextes, en les rapportant systemati...

Tópico(s): Argentine historical studies

2004 - Q23047551 | Clio

Artigo Acesso aberto Brasil Produção Nacional

Maria Ângela Pita Sobral, Maria Aparecida Alves de Cerqueira Luz, Adriana Gama-Teixeira, Narciso Garone Netto,

O objetivo deste trabalho foi estudar a importância do pH da dieta líquida na etiologia e prevenção das lesões de erosão dental, bem como conhecer o pH de algumas bebidas e sucos, supostamente ácidos, mais consumidos em nosso meio, para que fosse possível estabelecer uma comparação destes valores a fim de controlar a dieta dos pacientes portadores de lesões de erosão dental. Um único exemplar de cada fruta madura foi processado puro de modo a ser liquefeito e o pH foi medido utilizando-se um pH- ...

Tópico(s): Oral microbiology and periodontitis research

2000 - UNIVERSIDADE DE SÃO PAULO | Pesquisa Odontológica Brasileira

Artigo Revisado por pares

Joana Pinto, M. Rosário M. Domingues, Eulália Galhano, Cristina Pita, Maria do Céu Almeida, Isabel M. Carreira, Ana M. Gil,

The stability of human plasma composition was investigated by NMR, considering different collection tubes, time at room temperature (RT), short- and long-term storage conditions and up to 5 consecutive freeze–thaw cycles.

Tópico(s): Alcohol Consumption and Health Effects

2014 - Royal Society of Chemistry | The Analyst

Artigo Revisado por pares

Joana Pinto, António S. Barros, M. Rosário M. Domingues, Brian J. Goodfellow, Eulália Galhano, Cristina Pita, Maria do Céu Almeida, Isabel M. Carreira, Ana M. Gil,

This work presents the first NMR metabolomics study of maternal plasma during pregnancy, including correlation between plasma and urine metabolites. The expected decrease in circulating amino acids early in pregnancy was confirmed with six amino acids being identified as required by the fetus in larger extents. Newly observed changes in citrate, lactate, and dimethyl sulfone suggested early adjustments in energy and gut microflora metabolisms. Alterations in creatine levels were also noted, in addition ...

Tópico(s): Birth, Development, and Health

2014 - American Chemical Society | Journal of Proteome Research

Revisão Brasil Produção Nacional Revisado por pares

P. G. Rodhouse, Graham J. Pierce, Owen C. Nichols, WHH Sauer, Alexander I. Arkhipkin, Vladimir Laptikhovsky, M. Lipiński, Jorge E. Ramos, Michaël Gras, Hideaki Kidokoro, Kazuhiro Sadayasu, João Pereira, Evgenia Lefkaditou, Cristina Pita, Maria A. Gasalla, Manuel Haimovici, Mitsuo Sakai, Nicola Downey,

Cephalopods are a relatively small class of molluscs (~800 species), but they support some large industrial scale fisheries and numerous small-scale, local, artisanal fisheries. For several decades, landings of cephalopods globally have grown against a background of total finfish landings levelling off and then declining. There is now evidence that in recent years, growth in cephalopod landings has declined. The commercially exploited cephalopod species are fast-growing, short-lived ecological opportunists. ...

Tópico(s): Marine and fisheries research

2014 - Elsevier BV | Advances in marine biology

Artigo Acesso aberto Revisado por pares

José Antonio Muñoz‐Reyes, Miguel Pita, Maria Arjona, Santiago Sánchez‐Pagés, Enrique Turiégano,

Abstract The present paper analyzes the extent to which attractiveness-related variables affect cooperative behavior in women. Cooperativeness is evaluated through a Prisoner's Dilemma Game (PDG). We consider several morphometric variables related to attractiveness: fluctuating asymmetry (FA), waist–hip ratio (WHR), body mass index (BMI) and facial femininity (FF). These variables have been shown to predict human behavior. We also include as a control variable a score for self-perceived attractiveness ( ...

Tópico(s): Primate Behavior and Ecology

2013 - Elsevier BV | Evolution and Human Behavior

Artigo Revisado por pares

Iñaki Comino‐Méndez, Aguirre A. de Cubas, C. Bernal Bellido, Cristina Álvarez‐Escolá, Carolina Sánchez-Malo, César L. Ramírez-Tortosa, Susana Pedrinaci, Elena Rapizzi, Tonino Ercolino, Giampaolo Bernini, Alessandra Bacca, Rocío Letón, Guillermo Pita, María R. Alonso, Luis J. Leandro‐García, Álvaro Gómez-Graña, Lucía Inglada‐Pérez, Veronika Mančíková, Cristina Rodríguez‐Antona, Massimo Mannelli, Mercedes Robledo, Alberto Cascón,

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are chromaffin-cell tumors that arise from the adrenal medulla and extra-adrenal paraganglia, respectively. The dysfunction of genes involved in the cellular response to hypoxia, such as VHL, EGL nine homolog 1, and the succinate dehydrogenase (SDH) genes, leads to a direct abrogation of hypoxia inducible factor (HIF) degradation, resulting in a pseudo-hypoxic state implicated in PCC/PGL development. Recently, somatic post-zygotic mutations in EPAS1 ( ...

Tópico(s): Neuroblastoma Research and Treatments

2013 - Oxford University Press | Human Molecular Genetics

Artigo Revisado por pares

Sílvia O. Diaz, António S. Barros, Brian J. Goodfellow, Iola F. Duarte, Eulália Galhano, Cristina Pita, Maria do Céu Almeida, Isabel M. Carreira, Ana M. Gil,

Given the recognized lack of prenatal clinical methods for the early diagnosis of preterm delivery, intrauterine growth restriction, preeclampsia and gestational diabetes mellitus, and the continuing need for optimized diagnosis methods for specific chromosomal disorders (e.g., trisomy 21) and fetal malformations, this work sought specific metabolic signatures of these conditions in second trimester maternal urine, using 1H Nuclear Magnetic Resonance (1H NMR) metabolomics. Several variable importance ...

Tópico(s): Neonatal and fetal brain pathology

2013 - American Chemical Society | Journal of Proteome Research

Artigo Revisado por pares

Carlos Sáenz de la Calzada, Violeta Sánchez Sánchez, Maite Velázquez Martín, Rocío Tello de Meneses, Miguel A. Gómez Sánchez, Juan F. Delgado, Pilar Escribano Subías, Francisco García Gallego, Javier Ortigosa Aso, Antonio Melero Pita, María Salvador, Raúl Gascueña Rubia, Pedro Hernández Simón,

Primary pulmonary hypertension is a progressive disease. Most affected patients are young and middle-aged women. Etiology is unknown, although a familial and genetic factor is present in up to 6% of cases. Endothelial dysfunction and abnormalities in calcium channels of smooth muscle fibers are the present pathogenetics theories. Diagnostic tests try to exclude secondary causes of pulmonary hypertension and to evaluate its severity. Acute vasodilatory test is vital in the selection of treatment. ...

Tópico(s): Atrial Fibrillation Management and Outcomes

2001 - Elsevier BV | Revista Española de Cardiología