Malcolm Brown, Barbara Hall, Will Ellsworth-Jones, John Jay City Editor, John Davison, Jon Swain, Anthony Clare, Chris Ryder, Catherine Boruett, Rob Hughes, John Peter, Dr G. A. Rodgers, Frank Akers-Douglas, Eric Dymock, Christopher Smallwood Economics Editor, Jane Bird Computer Correspondent, John Jay, Ian MacGregor, Neville Hodgkinson Medical Correspondent, Graham Rose, Wayne Lintott, Diana Wright Personal Finance Editor, E. Jenkins, John Dillon, Brian Waiden, Mark Lawson, Shamim Khan, Phillip Hickey, Julian Symons, Marten Julian, Steve Jordan, W. Eugene Smith, Peter Woolrich, Jason Tomas, Henry Porter, Cal McCrystal, Tony Hurd, Jancis Robinson, Bruce Kemble, Nigel Lawson, John Westwell, Judi Bevan Deputy City Editor, Patrick Stoddart, Neville Hodgkinson, Susans Raby, George Feifer, Irwin Stelzer, John Newell, Robert Hewison, Ivan Fallon, Deryk Brown, Roger Eglin Business News Editor, Keith Botsford, Franco Zeffirelli, David Dougill, John Mortimer, Malcolm Bradbury, John Witherow, Gareth Daniels, Michael Bryant, Russell Harty, Sheri Tullah, David Cairns, Len Brooks, Norman Harris, Marthias Bamert, David Connett, Toby Moore, Nicholas Ashehov, Giles Merritt, Paul Eddy, Geoff Whitten, John McGrath, Yvonne Roberts, Anthony Quinton, Jenny MacArthur, George Perry, J Hendeles, Peta Hunt, Gforgina Howell, Bernard Cafferty, Brian Moynahan, James Power, Amit Roy, Bryon Rogers, Angela Newing, Robert Muller, Anne Jacobs Local Government Correspondent, David Leppard, Martin Bashir, Tim Rayment, John Witherow Diplomatic Correspondent, C. S-J., Askold Krushelnycky, Liz Jobey, Judi Bevan, Jill Neville, Philip Riley, David Toop, Eric Marsden, Julia Hide, Steve Ellis, Cheryl Taylor, Paul Gooch, Norman Lebreckt, Diana Wright, Christopher Smallwood, James Adams Defence Correspondent, Stephen Jones, Melvyn Bragg, Dr D. G. Boyle Lecturer in Psychology, Patrick Rowley, Bruce Kemble Education Correspondent, Dilys Powell, D. G. Rhys Smmt Professor of Motor Industry Economics, Brough Scott, Deyan Sudjic, Norman Stone, Clive Everton, Richard Woods, Samantha Fox, Louise Branson, Peter Johnson, Simon Winchester, Maurice Chittenden, Barrie Penrose, J. McE, David Hughes Political Correspondent, Mitchell Plotts, Tim Blackstone, Michael Jones Political Editor, Matthew Parris, Anthony Summers, Mihir Bose, Simon Callow, Philip Beresford, Godfrey Smith, Annabel Walker, Charles Oulton, Gordon Smith, Brian Glanville, John Carey, Bill Martin, David Sinclair, Jack Rosenthal, Will Elisworth-Jones, Nicholas Asheshov The Sunday Times Correspondent, Neil Sanderson, Ian Williams, Simon Rose, Peter Jenkins, John Bellany, Marina Vaizey, Margaret Park, Tony Hetherington, Ray Whitney, Roger Ratcliffe, Jon Connell, Leslie Geddes-Brown, Guy Williams, Mark Brennan,
... Rose Coloured Spectacles Poet, Philosopher and Existential Cook? Silvia Ziranek is All of These and a Leading ...
1986 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Luíz Tadeu Moraes Figueiredo, Marcos Costa Simões, Sílvia Maria Baéta Cavalcante,
... this author on: Oxford Academic PubMed Google Scholar Silvia Maria Baêta Cavalcante Silvia Maria Baêta Cavalcante Virology Department, Oswaldo Cruz Foundation, Ministry ...
Tópico(s): Vector-borne infectious diseases
1989 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene
Angela Thorpe, Frances Gibb, Legal Affairs Correspondent, Juan Carlos Gumucio, Chris Petit, Clifford Longley, J. E. Humphrey, Vivien Goldsmith Family Money Editor, Peter Shaffer, Andrew Billen, Simon O'Hagan, Jane MacQuitty, Victor Zorza and Veenu Sandal, Simon Barnes, S. C. P, Peter Philp, Philip Greig, Bruce Hiscock, Qamar Ahmed, Michael Seely, Racing Correspondent, Philip Howard, John Bell, City Editor, Jeremy Kingston, James Bone, James Capel, W. M. Mackean, Sheila Frewin, Director, Jeremy Flint, David Hay, Mark Souster and Harvey Elliott, Mario Modiano, S. Prebble, Editor, Colin Narbrough, Vivien Goldsmith, Howard Foster, Francesca Greenoak, Henry Gee, Andrew Rowe, Christopher Shennan, Peter Davenport, Michael Tate, Hilary Doling, Pearce Wright Science Editor, Richard Burton, Andrew Moger, Louise Taylor, Lawrence Lever, Liz Forgan, Mick Cleary, Craig Seton, Ian Smith, and Sam Kiley, Peter Bills, Rowan Bosworth-Davies, Robin Young, Robert Nye, Martin Fletcher, Political Reporter, Peter Sutherland, Frances Bissell, Peter Davelle, Rex Bellamy, David Hands, Charles Bremner, Michael Grylls, Richard Thomson, Banking Correspondent, Edward Gorman, Peter Lewis, Max Harrison, Sam Kiley, Universities Reporter, Jack Waterman, Harvey Elliott, Air Correspondent, Andrew Hislop, James G. Bradshaw, George Brock, Sydney Friskin, Robert Matthews Technology Correspondent, Nigel Andrew, Mel Webb La Moye, Roger Boyes, Pallanza, and Richard Owen, Roger FitzGERALD, Christopher Goulding, Michael Watkins, Raymond Keene, David Brewerton Executive Editor, Roy Hay, R. Applebee, Elisabeth A. Otter, Paul Griffiths, Steve Acteson, Peter Bryan, David Hunt, W. J. Burroughs, R. A. W. Longden, Tony Levene, Richard Evans, Martin Trew, Iain Liddell, Craig Seton, John Blunsden, Richard Evans Media Editor, Raymond Plant, David Young, Energy Correspondent, Martin Searby, Barry Pickthall, Irving Wardle, Roger Boyes, Ian Ross, Derek Harris, Industrial Editor, Keith MacKlin, Deyan Sudjic, Kenneth Fleet, Christopher Thomas, Anne Campbell Dixon, Philip Webster Chief Political Correspondent, Christopher Walker, Madsen Pirie, President, Carol Ferguson, Brian Alderson, Eamonn Butler, Director, Clive White, Michael Horsnell and Andrew Moger, Sarah Jane Checkland Art Market Correspondent, James Platt, Peter Clarke, Michael Seely, David Gollob, Michael Clark and Geoffrey Foster, P. D., Andrew Lycett, David Sinclair, Stephen Pettitt, Tim Jones, Martin Waller, Harvey Elliot, Air Correspondent, Rachel Warren, Edward Frewin, Managing Director, Michael Schluter, Bailey Morris, Frances Dickenson and Caz Gorham, Jonathan Meades, Hugh Thompson, Michael Evans Defence Correspondent, Veronica Heath, Maria Scott, Pearce Wright, Science Editor, Colin Campbell, Shona Crawford Poole, Judy Froshaug, Philip Jacobson, David Hands, Rugby Correspondent, J. Bunting, Michael Schluter, Director, David Walker, Public Administration Correspondent, Philip Ray, Richard Williams,
... Riding Centre Linkwood Equestrian Centre Outgrown your Pony? Silvia Stanier L. V. O The Quantock Riding Centre ...
1988 - Gale Group | TDA
Produção Nacional
Revisado por pares
Priscila Dabaghi-Barbosa, Priscila Dabaghi-Barbosa, Andreia Mariante Rocha, Priscila Dabaghi-Barbosa, Andreia Mariante Rocha, Anderson Franco da Cruz Lima, Priscila Dabaghi-Barbosa, Andreia Mariante Rocha, Anderson Franco da Cruz Lima, Brás Heleno de Oliveira, Priscila Dabaghi-Barbosa, Andreia Mariante Rocha, Anderson Franco da Cruz Lima, Brás Heleno de Oliveira, Maria Benigna Martinelli de Oliveira, Priscila Dabaghi-Barbosa, Andreia Mariante Rocha, Anderson Franco da Cruz Lima, Brás Heleno de Oliveira, Maria Benigna Martinelli de Oliveira, Eva Gunilla Skäre Carnieri, Priscila Dabaghi-Barbosa, Andreia Mariante Rocha, Anderson Franco da Cruz Lima, Brás Heleno de Oliveira, Maria Benigna Martinelli de Oliveira, Eva Gunilla Skäre Carnieri, Sílvia Maria Suter Correia Cadena, Priscila Dabaghi-Barbosa, Andreia Mariante Rocha, Anderson Franco da Cruz Lima, Brás Heleno de Oliveira, Maria Benigna Martinelli de Oliveira, Eva Gunilla Skäre Carnieri, Sílvia Maria Suter Correia Cadena, Maria Eliane Merlin Rocha, Priscila Dabaghi-Barbosa, Andreia Mariante Rocha, Anderson Franco da Cruz Lima, Brás Heleno de Oliveira, Maria Benigna Martinelli de Oliveira, Eva Gunilla Skäre Carnieri, Sílvia Maria Suter Correia Cadena, Maria Eliane Merlin Rocha,
Hispidulin (6-methoxy-5,7,4′-trihydroxyflavone) and eupafolin (6-methoxy-5,7,3′,4′-tetrahydroxyflavone), are flavonoids found in the leaves of Eupatorium litoralle. They have recognized antioxidant and antineoplastic properties, although their action mechanisms have not been previously described. We now report the effects of hispidulin on the oxidative metabolism of isolated rat liver mitochondria (Mit) and have also investigated the prooxidant and antioxidant capacity of both flavonoids. Hispidulin ( ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2005 - Taylor & Francis | Free Radical Research
Silvia Caimmi, Enrica Manca, Davide Caimmi, Gian Luigi Marseglia, Pascal Demoly,
... Letters to the Editor NSAID hypersensitivity in twins Silvia Maria Elena Caimmi, Silvia Maria Elena Caimmi [email protected] Department of Pediatrics, Foundation ... Paris, FranceSearch for more papers by this author Silvia Maria Elena Caimmi, Silvia Maria Elena Caimmi [email protected] Department of Pediatrics, Foundation ...
Tópico(s): Asthma and respiratory diseases
2014 - Wiley | Pediatric Allergy and Immunology
Olga Vaccaro, Maria Masulli, Antonio Nicolucci, Enzo Bonora, Stefano Del Prato, Aldo P. Maggioni, Angela A. Rivellese, Sebastiano Squatrito, Carlo Giorda, Giorgio Sesti, Paolo Mocarelli, Giuseppe Lucisano, Michele Sacco, Stefano Signorini, Fabrizio Cappellini, G. Perriello, A.C. Babini, Annunziata Lapolla, Giovanna Gregori, Carla Giordano, L. Corsi, Raffaella Buzzetti, Gennaro Clemente, Graziano Di Cianni, R. Iannarelli, Renzo Cordera, Olga La Macchia, Chiara Zamboni, Cristiana Scaranna, Massimo Boemi, C Iovine, Davide Lauro, Sergio Leotta, Elisabetta Dall’Aglio, Emanuela Cannarsa, Laura Tonutti, Giuseppe Pugliese, Antonio Bossi, Roberto Anichini, Francesco Dotta, A. Di Benedetto, Giuseppe Citro, D. Antenucci, Lucia Ricci‐Vitiani, Francesco Giorgino, Costanza Santini, Agostino Gnasso, Salvatore De Cosmo, D. Zavaroni, Monica Vedovato, Agostino Consoli, Maria Calabrese, Paolo Di Bartolo, Paolo Fornengo, Gabriele Riccardi, Olga Vaccaro, Maria Masulli, Antonio Nicolucci, Aldo P. Maggioni, Giorgio Sesti, Paolo Mocarelli, Giuseppe Lucisano, Michele Sacco, Stefano Signorini, Fabrizio Cappellini, Gabriele Riccardi, Massimo Boemi, Federica D’Angelo, R. Giansanti, Laura Tanase, Luigi Lanari, I Testa, Lucia Ricci‐Vitiani, Francesca Pancani, A. Ranchelli, Paolo Vagheggi, Alessia Scatona, Lucia Fontana, Francesco Giorgino, Luigi Laviola, Lucia Tarantino, Claudia Ippolito, Vittoria Gigantelli, Mariangela Manicone, Eleonora Conte, Roberto Trevisan, Cristiana Scaranna, Rossella Rota, A. Corsi, Alessandro Roberto Dodesini, Giulio Marchesini, Luca Montesi, Natalia Mazzella, Gabriele Forlani, Chiara Caselli, Raffaella Di Luzio, Arianna Mazzotti, Antimo Aiello, Angelina Barrea, Antonio Musto, Fiorentina D'Amico, Sebastiano Squatrito, Tiziana Sinagra, Sara Longhitano, Vanessa Trowpea, Maria Sparti, Salvatore Italia, Enrico Lisi, Giuseppe Grasso, V. Pezzino, F. Insalaco, Agostino Gnasso, Claudio Carallo, Concetta Arianna Scicchitano, Maria Serena De Franceschi, Costanza Santini, Arianna Mazzotti, Chiara Caselli, Giovanni Calbucci, R Ripani, L. Corsi, Giacomo Cuneo, Simona Corsi, Carlo Giorda, Francesco Romeo, A Lesina, Marco Comoglio, Caterina Bonetto, Anna Robusto, Elisa Nada, Vincenzo Asprino, Rosa Cetraro, M Impieri, Giuseppe Lucchese, Giovanna Donnarumma, Biagio Tizio, Gennaro Clemente, Lazzaro Lenza, Pia Paraggio, Franco Tomasi, Chiara Zamboni, Nicoletta Dozio, Egle Scalambra, Edoardo Mannucci, Caterina Lamanna, Mauro Cignarelli, Olga La Macchia, Stefania Fariello, Maria Rosaria Sorrentino, Ivano Franzetti, Raffaella Radin, Renzo Cordera, Francesca Annunziata, Laura Affinito Bonabello, Arianna Durante, Mara Dolcino, Fiorenza Gallo, Chiara Mazzucchelli, Anna Aleo, P Melga, L. Briatore, Davide Maggi, Daniela Storace, Francesca Cecoli, D. Antenucci, Ercole D'Ugo, Mario Pupillo, M Baldassarre, Filippo Salvati, A Minnucci, Angelo De Luca, Antonella Zugaro, Livia Santarelli, Angela Bosco, Vittorio Petrella, Grazia Giovanna La Verghetta, R. Iannarelli, Antonella De Gregorio, Settimio D’Andrea, Anna Elisa Giuliani, w Lorella Polidoro, Alessandra Sperandio, Filomena Sciarretta, Alfonso Pezzella, Raffaella Buzzetti, Angela Carlone, Stella Potenziani, Chiara Venditti, Chiara Foffi, Salvatore Carbone, Laura Cipolloni, Chiara Moretti, Gaetano Leto, Rosalia Serra, Francesca Petrachi, Isabella Romano, Graziano Di Cianni, Emilia Lacaria, Laura Russo, Chiara Goretti, Claudia Sannino, Giovanna Gregori, Maria Dolci, L Bruselli, Mary Mori, Fabio Baccetti, Maria Del Freo, Lucia Fontana, A. Di Benedetto, Domenico Cucinotta, Loretta Giunta, Maria Concetta Ruffo, Domenico Cannizzaro, Basilio Pintaudi, Giovanni Perrone, P Pata, Francesco Ragonese, Gabriele Lettina, Teresa Mancuso, Aldo Coppolino, Pier Marco Piatti, Lucilla D. Monti, Michela Stuccillo, Pietro Lucotti, Manuela Setola, Giulia Valentina Crippa, Cinzia Loi, Matteo Oldani, Maria Luisa Bottalico, Beatrice Pellegata, Matteo Bonomo, Laura Silvia Maria Menicatti, Veronica Resi, Federico Bertuzzi, Olga Disoteo, Gianluigi Pizzi, Angela A. Rivellese, Giovanni Annuzzi, Brunella Capaldo, Rossella Nappo, Stefania Auciello, Anna Turco, Lucia Costagliola, C Iovine, Giuseppina Della Corte, P. Vallefuoco, Francesca Nappi, Marilena Vitale, Sara Cocozza, Ornella Ciano, Elena Massimino, Nadia Garofalo, Angelo Avogaro, Monica Vedovato, G. Guarneri, Annunziata Lapolla, Domenico Fedele, Giovanni Sartore, Nino Cristiano Chilelli, Silvia Burlina, Barbara Bonsembiante, Carla Giordano, Aldo Galluzzo, Vittoria Torregrossa, Elisabetta Dall’Aglio, Giovanni Luigi Francesco Mancastroppa, L Arsenio, F. Cioni, S Caronna, Matteo Papi, Massimiliano Babini, G. Perriello, Fausto Santeusanio, Gioia Calagreti, A. Timi, Alice Tantucci, Cecilia Marino, Agostino Consoli, Federica Ginestra, Rosamaria Di Biagio, Merilda Taraborelli, Stefano Del Prato, Roberto Miccoli, Cristina Bianchi, Monia Garofolo, Konstantina Savina Politi, Giuseppe Penno, D. Zavaroni, Stefania Livraga, F. Calzoni, Giovanni Luigi Francesco Mancastroppa, Roberto Anichini, Elisa Corsini, Anna Tedeschi, Maria Sole Gaglianò, Giulio Ippolito,
Summary Background The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. Methods TOSCA.IT was a multicentre, randomised, pragmatic clinical trial, in which patients aged 50–75 years with type 2 diabetes inadequately controlled with metformin ...
Elsevier BV
Produção Nacional
Ana Paula Melo Mariano, Esther Nascimento Santos, Talita Nogueira dos Santos, Tilson Nunes Mota, Juliana Almeida‐Silva, Sílvia Maria Santos Carvalho, Marcelo Fernandes da Silva,
... Santos, Tilson Nunes Mota, Juliana Almeida da Silva1, Silvia Maria Santos Carvalho, Marcelo Fernandes da Silva Abstract Intestinal ...
Tópico(s): Parasitic Infections and Diagnostics
2015 - | International Journal of Health Sciences (IJHS)
Produção Nacional
Revisado por pares
Juliana Cordeiro de Sousa, Mayumi Ito, Marília Braga Costa, Izabelle Rocha Farias, Daniela de Paula Borges, Roberta Taiane de Oliveira, Kiyoshi F. Fukutani, Carolina Hassibe Thomé, Camila Maria da Silva Martinelli, Fabio Myajima, Daniel Onofre Vidal, Sílvia Maria Meira Magalhães, Lorena Lôbo Figueiredo-Pontes, Ronald Feitosa Pinheiro,
... more papers by this authorSilvia Maria Meira Magalhães, Silvia Maria Meira Magalhães Cytogenomic Laboratory, Postgraduate Medical Science, University ... more papers by this authorSilvia Maria Meira Magalhães, Silvia Maria Meira Magalhães Cytogenomic Laboratory, Postgraduate Medical Science, University ...
Tópico(s): Lymphoma Diagnosis and Treatment
2019 - Wiley | Hematological Oncology
Produção Nacional
Revisado por pares
Renata Bressan Pepe, Ana Maria Lottenberg, Clarissa Tamie Hiwatashi Fujiwara, Mônica Beyruti, Dennys E. Cintra, Roberta Marcondes Machado, Alessandra Rodrigues, Natália Sanchez Oliveira Jensen, Ana Paula Silva Caldas, Ariana Ester Fernandes, Carina Rossoni, Fernanda Mattos, João Henrique Fabiano Motarelli, Josefina Bressan, Juliana F. Saldanha, Lis Mie Masuzawa Beda, Maria Sílvia Ferrari Lavrador, Mariana Del Bosco, patricia cruz, Poliana Espíndola Correia, Priscila Maximino, Sílvia Pereira, Sílvia Leite Faria, Silvia Maria Fraga Piovacari,
Obesity is a chronic disease resulting from multifactorial causes mainly related to lifestyle (sedentary lifestyle, inadequate eating habits) and to other conditions such as genetic, hereditary, psychological, cultural, and ethnic factors. The weight loss process is slow and complex, and involves lifestyle changes with an emphasis on nutritional therapy, physical activity practice, psychological interventions, and pharmacological or surgical treatment. Because the management of obesity is a long- ...
Tópico(s): Consumer Attitudes and Food Labeling
2023 - BioMed Central | Diabetology & Metabolic Syndrome
Produção Nacional
Revisado por pares
Idam de Oliveira‐Junior, Cristiano Ribeiro Viana, Silvia Maria Prioli de Souza Sabino, Lígia Maria Kerr, René Aloísio da Costa Vieira,
... authorSilvia Maria Prioli de Souza Sabino MD, MSc, Silvia Maria Prioli de Souza Sabino MD, MSc Radiology Division, ... authorSilvia Maria Prioli de Souza Sabino MD, MSc, Silvia Maria Prioli de Souza Sabino MD, MSc Radiology Division, ...
Tópico(s): Oral and Maxillofacial Pathology
2016 - Wiley | The Breast Journal
Maria Silvia Guidetti, Colombina Vincenzi, Mauro Papi, Antonellá Tosti,
... Sclerodcrmatous skin reaction after vitamin K1 injections Maria Silvia Guidetti, Maria Silvia Guidetti Department of Dermatology, University of Bologna, ... ItalySearch for more papers by this author Maria Silvia Guidetti, Maria Silvia Guidetti Department of Dermatology, University of Bologna, Via ...
Tópico(s): Dermatological and Skeletal Disorders
1994 - Wiley | Contact Dermatitis
Maria Silvia Guidetti, Colombina Vincenzi, Liliana Guerra, Antonellá Tosti,
... 282 Contact dermatitis due to imidazole antimycotics Maria Silvia Guidetti, Maria Silvia Guidetti Department of Dermatology, University of Bologna, ... ItalySearch for more papers by this author Maria Silvia Guidetti, Maria Silvia Guidetti Department of Dermatology, University of Bologna, Via ...
Tópico(s): Nail Diseases and Treatments
1995 - Wiley | Contact Dermatitis
Maria Silvia Guidetti, Colombina Vincenzi, Liliana Guerra, Antonellá Tosti,
... 261 Contact dermatitis due to oleyl alcohol Maria Silvia Guidetti, Maria Silvia Guidetti Department of Dermatology, University of Bologna, ... ItalySearch for more papers by this author Maria Silvia Guidetti, Maria Silvia Guidetti Department of Dermatology, University of Bologna, Via ...
Tópico(s): Occupational exposure and asthma
1994 - Wiley | Contact Dermatitis
Produção Nacional
Revisado por pares
M Cardia, Ileana Gabriela Sanchez Rubio, Geraldo Medeiros‐Neto,
... preceded or not by human recombinant TSH Maria Silvia Cardia, Maria Silvia Cardia University São Paulo Medical School, Thyroid ... BrazilSearch for more papers by this author Maria Silvia Cardia, Maria Silvia Cardia University São Paulo Medical School, Thyroid Unit, ...
Tópico(s): Thyroid Disorders and Treatments
2006 - Wiley | Clinical Endocrinology
Silvia Maria Sirchia, Silvia Tabano, Laura Monti, Maria Paola Recalcati, Manuela Gariboldi, Francesca Romana Grati, Giovanni Porta, Palma Finelli, Paolo Radice, Monica Miozzo,
A role of X chromosome inactivation process in the development of breast cancer have been suggested. In particular, the relationship between the breast cancer predisposing gene BRCA1 and XIST, the main mediator of X chromosome inactivation, has been intensely investigated, but still remains controversial. We investigated this topic by assessing XIST behaviour in different groups of breast carcinomas and in a panel of breast cancer cell lines both BRCA1 mutant and wild type. In addition, we evaluated ...
Tópico(s): CRISPR and Genetic Engineering
2009 - Public Library of Science | PLoS ONE
Davide Gentilini, Daniela Mari, Davide Castaldi, Daniel Remondini, Giulia Ogliari, Rita Ostan, Laura Bucci, Silvia Maria Sirchia, Silvia Tabano, Francesco Cavagnini, Daniela Monti, Claudio Franceschi, Anna Maria Di Blasio, Giovanni Vitale,
The role of epigenetics in the modulation of longevity has not been studied in humans. To this aim, (1) we evaluated the DNA methylation from peripheral leukocytes of 21 female centenarians, their 21 female offspring, 21 offspring of both non-long-lived parents, and 21 young women through ELISA assay, pyrosequencing analysis of Alu sequences, and quantification of methylation in CpG repeats outside CpG islands; (2) we compared the DNA methylation profiles of these populations through Infinium array ...
Tópico(s): Identity, Memory, and Therapy
2012 - Springer Science+Business Media | AGE
Elena Lesma, Silvia Maria Sirchia, Silvia Ancona, Stephana Carelli, Silvano Bòsari, Filippo Ghelma, E. Montanari, Anna Maria Di Giulio, Alfredo Gorio,
Tuberous sclerosis complex (TSC) is an autosomal-dominant disease that is caused by mutations in either the TSC1 or TSC2 gene. Smooth muscle-like cells (ASMs) were isolated from an angiomyolipoma of a patient with TSC. These cells lacked tuberin, were labeled by both HMB45 and CD44v6 antibodies, and had constitutive S6 phosphorylation. The cells bear a germline TSC2 intron 8-exon 9 junction mutation, but DNA analysis and polymerase chain reaction amplification failed to demonstrate loss of heterozygosity. ...
Tópico(s): Vascular Tumors and Angiosarcomas
2009 - Elsevier BV | American Journal Of Pathology
Laura Fontana, Maria Francesca Bedeschi, Silvia Maitz, Anna Cereda, Claudia Farè, S. Motta, Agostino Seresini, Pasqualina D’Ursi, Alessandro Orro, Vanna Pecile, Mariarosaria Calvello, Angelo Selicorni, Faustina Lalatta, Donatella Milani, Silvia Maria Sirchia, Monica Miozzo, Silvia Tabano,
The identification of multilocus imprinting disturbances (MLID) appears fundamental to uncover molecular pathways underlying imprinting disorders (IDs) and to complete clinical diagnosis of patients. However, MLID genetic associated mechanisms remain largely unknown. To characterize MLID in Beckwith-Wiedemann (BWS) and Silver-Russell (SRS) syndromes, we profiled by MassARRAY the methylation of 12 imprinted differentially methylated regions (iDMRs) in 21 BWS and 7 SRS patients with chromosome 11p15.5 ...
Tópico(s): Prenatal Screening and Diagnostics
2018 - Landes Bioscience | Epigenetics
Lluc Coll, M Parriego, Silvia María Mateo, Sílvia García-Monclús, Ignacio Rodríguez, Montserrat Boada, Buenaventura Coroleu, Nikolaos P. Polyzos, Francesca Vidal, Anna Veiga,
Research question Are intrinsic or extrinsic factors associated with embryo mosaicism prevalence in IVF cycles? Design Retrospective cohort study of preimplantation genetic testing for aneuploidy (PGT-A) cycles carried out at a university-affiliated IVF clinic between October 2017 and October 2019. Trophectoderm biopsies were analysed by next generation sequencing. Mosaicism prevalence, type of anomaly and the chromosomes involved were analysed. Intrinsic and extrinsic factors potentially inducing ...
Tópico(s): Reproductive Health and Technologies
2020 - Elsevier BV | Reproductive BioMedicine Online
Flavia Cerrato, Angela Sparago, Francesca Ariani, Fulvia Brugnoletti, Luciano Calzari, Fabio Coppedè, Alessandro De Luca, Cristina Gervasini, Emiliano Giardina, Fiorella Gurrieri, Cristiana Lo Nigro, Giuseppe Merla, Monica Miozzo, Silvia Russo, Eugenio Sangiorgi, Silvia Maria Sirchia, Gabriella Maria Squeo, Silvia Tabano, Elisabetta Tabolacci, Isabella Torrente, Maurizio Genuardi, Giovanni Neri, Andrea Riccio,
DNA methylation in the human genome is largely programmed and shaped by transcription factor binding and interaction between DNA methyltransferases and histone marks during gamete and embryo development. Normal methylation profiles can be modified at single or multiple loci, more frequently as consequences of genetic variants acting in cis or in trans, or in some cases stochastically or through interaction with environmental factors. For many developmental disorders, specific methylation patterns ...
Tópico(s): Cancer-related gene regulation
2020 - Multidisciplinary Digital Publishing Institute | Genes
Fabrizio Lirer, Luca Maria Foresi, Silvia Maria Iaccarino, Gianfranco Salvatorini, Elena Turco, Claudia Cosentino, Francisco Javier Sierro, Antonio Caruso,
Tópico(s): earthquake and tectonic studies
2019 - Elsevier BV | Earth-Science Reviews
Eleonora Bonaparte, Chiara Pesenti, Laura Fontana, Rossella Falcone, Leda Paganini, Anna Marzorati, Stefano Ferrero, Mario Nosotti, Paolo Mendogni, Claudia Bareggi, Silvia Maria Sirchia, Silvia Tabano, Silvano Bòsari, Monica Miozzo,
Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tumor heterogeneity, frequent material scarcity, and the large number of loci to be investigated, must be taken into account in selecting the most appropriate technique. MALDI-TOF mass spectrometry (MS), which allows multiplexed genotyping, has been adopted in routine diagnostics as a sensitive, ...
Tópico(s): Genomics and Phylogenetic Studies
2018 - BioMed Central | Diagnostic Pathology
Produção Nacional
Revisado por pares
Carlos Eduardo Alves de Souza, Helen de Morais Alves de Souza, Maria Carolina Stipp, Cláudia Rita Corso, Claudia Martins Galindo, Carolina R. Cardoso, Rosângela Locatelli Dittrich, Edneia Amancio de Souza Ramos, Giseli Klassen, Rose Maria Carlos, Sílvia Maria Suter Correia Cadena, Alexandra Acco,
The present study evaluated the in vivo antitumor effects and toxicity of a new Ru(II) compound, cis-(Ru[phen]2[ImH]2)2+ (also called RuphenImH [RuC]), against Walker-256 carcinosarcoma in rats. After subcutaneous inoculation of Walker-256 cells in the right pelvic limb, male Wistar rats received 5 or 10mgkg-1 RuC orally or intraperitoneally (i.p.) every 3 days for 13 days. A positive control group (2mgkg-1 cisplatin) and negative control group (vehicle) were also used. Tumor progression was checked ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2017 - Elsevier BV | Free Radical Biology and Medicine
Paolo Mereghetti, Paola Antonia Corsetto, Andrea Cremona, Angela Maria Rizzo, Silvia Maria Doglia, Diletta Ami,
Detergent resistant membranes (DRMs) are a useful model system for the in vitro characterization of cell membrane domains. Indeed, DRMs provide a simple model to study the mechanisms underlying several key cell processes based on the interplay between specific cell membrane domains on one hand, and specific proteins and/or lipids on the other. Considering therefore their biological relevance, the development of methods capable to provide information on the composition and structure of membrane domains ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2014 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Anna Caretti, Silvia Maria Sirchia, Silvia Tabano, Aı́da Zulueta, Fabio Dall’Olio, Marco Trinchera,
The native promoter of β1,3 galactosyltransferase β3Gal-T5 contributes to the expression of the enzyme and its oligosaccharide products, such as Lewis antigens, in many tissues. It is mainly sensitive to nuclear factor NF-Y and located nearby two CpG islands. To elucidate the regulation of the native promoter, we analyzed NF-Y protein and β3Gal-T5 mRNA, and found that NF-Y is scarcely modulated among various cell lines and biopsies from normal or cancerous colon. Conversely, β3Gal-T5 expression ...
Tópico(s): Genomics and Chromatin Dynamics
2011 - Elsevier BV | The International Journal of Biochemistry & Cell Biology
Luca Maria Foresi, Silvia Maria Iaccarino, Gianfranco Salvatorini,
A new subspecies of Neogloboquadrina atlantica atlantica previously reported under different names, is here distinguished and named Neogloboquadrina atlantica praeatlantica . Its first occurrence into the Mediterranean dated at 11.78 Ma, is not evolutionary appearance but is related to a global climatic cooling which pushed southwards from high latitude this taxon; however, the area of its evolutionary appearance is not clearly defined; its extinction occurs within the Globigerinoides obliquus extremus ...
Tópico(s): Mollusks and Parasites Studies
2002 - University of Milan | RIVISTA ITALIANA DI PALEONTOLOGIA E STRATIGRAFIA
Silvia Russo, Luciano Calzari, Alessandro Mussa, Ester Mainini, Matteo Cassina, Stefania Di Candia, Maurizio Clementi, Sara Guzzetti, Silvia Tabano, Monica Miozzo, Silvia Maria Sirchia, Palma Finelli, Paolo Prontera, Silvia Maitz, Giovanni Sorge, Annalisa Calcagno, Mohamad Maghnie, Maria Teresa Divizia, Daniela Melis, Emanuela Manfredini, Giovanni Battista Ferrero, Vanna Pecile, Lidia Larizza,
Multiple (epi)genetic defects affecting the expression of the imprinted genes within the 11p15.5 chromosomal region underlie Silver-Russell (SRS) and Beckwith-Wiedemann (BWS) syndromes. The molecular diagnosis of these opposite growth disorders requires a multi-approach flowchart to disclose known primary and secondary (epi)genetic alterations; however, up to 20 and 30 % of clinically diagnosed BWS and SRS cases remain without molecular diagnosis. The complex structure of the 11p15 region with variable ...
Tópico(s): Prenatal Screening and Diagnostics
2016 - BioMed Central | Clinical Epigenetics
Produção Nacional
Revisado por pares
Marianna Manes, Mariana de Souza Aranha Garcia-Gomes, Thaísa Meira Sandini, Julia Zaccarelli‐Magalhães, Jorge Camilo Flório, Sandra Regina Alexandre-Ribeiro, Danilo Wadt, Maria Martha Bernardi, Sílvia Maria Gomes Massironi, Cláudia Madalena Cabrera Mori,
Otoconia are crucial for the correct processing of positional information and orientation. Mice lacking otoconia cannot sense the direction of the gravity vector and cannot swim properly. This study aims to characterize the behavior of mergulhador (mlh), otoconia-deficient mutant mice. Additionally, the central catecholamine levels were evaluated to investigate possible correlations between behaviors and central neurotransmitters. A sequence of behavioral tests was used to evaluate the parameters ...
Tópico(s): Vestibular and auditory disorders
2018 - Elsevier BV | Behavioural Brain Research
Produção Nacional
Revisado por pares
C R de Farias, Bárbara Rita Cardoso, G M B de Oliveira, Izabel Cristina Guazzelli, Regina Maria Catarino, Maria Cristina Chammas, Sílvia Maria Franciscato Cozzolino, Meyer Knobel,
Tópico(s): Vitamin D Research Studies
2015 - Springer Science+Business Media | Journal of Endocrinological Investigation
Produção Nacional
Revisado por pares
Marcella Bonanomi, Antonino Natalello, Cristina Visentin, Valentina Pastori, Amanda Penco, Giuseppina Cornelli, Giorgio Colombo, Maria Grazia Malabarba, Silvia Maria Doglia, Annalisa Relini, Maria Elena Regonesi, Paolo Tortora,
The polyglutamine (polyQ)-containing protein ataxin-3 (AT3) triggers the neurodegenerative disease spinocerebellar ataxia type 3 (SCA3) when its polyQ tract is expanded beyond a critical length. This results in protein aggregation and generation of toxic oligomers and fibrils. Currently, no effective treatment is available for such and other polyQ diseases. Therefore, plenty of investigations are being carried on to assess the mechanism of action and the therapeutic potential of anti-amyloid agents. ...
Tópico(s): Prion Diseases and Protein Misfolding
2014 - Oxford University Press | Human Molecular Genetics