Ronald McLaren, St Andrews, Giles Smith, Gabriele Marcotti, Phil Yates, Jon Ashworth, Carol Lewis, Tony Travers, Robert Cole, Andrew Pierce, Richard Irving and Adam Sherwin, P. A. Lee, St John, Jersey, Adam Sherwin Media Reporter, James Ducker and Tom Dart, Frances Gibb Legal Editor, Gary Duncan, Peter Lansley, Richard Beeston, Roger Maynard and David Adams, Dr Thomas Stuttuford, Mark Souster, Tim Phillips, Richard Hobson, David Rose, J. Armistead, Michael Evans Defence Editor, Trevor Openshaw, Philip Howard, Hannah Betts, Jason Solomons, Christine Seib, David Chater, Angela McManus, Rachel Campbell-Johnston, James Bone, James Ducker, Alexandra Frean Social Affairs Correspondent, Richard Irving, Carl Mortished, Tom Baldwin and Helen Rumbelow, Sean O'Neill and Ian Evans, John E. Stiles, Sam Marlowe, Wendy Ide, Jeremy Whittle, Kevin Eason, Shobana Jeyasingh, Geoff Brown, Andrew Norfolk, Ben Webster Transport Correspondent, Jamie Tosh, Pat Gibson, David McVay, Lord Harris, Betty Jackson, Stewart Tendler Crime Correspondent, Anthea Del Mar, Dominic Walsh, Tom Bawden, Gary Jacob, Jill Dupleix, Tim Reid, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Paul Hegarty, Richard Ford Home Correspondent, Nicholas Blanford, Anatole Kaletsky, David Hands, Charles Bremner, J. P. Johnson, Brian B. Scott, Robert Balfour, Edward Gorman, Hugo Rifkind, Michael Howard, Russell Kempson, Jack Perris, Dan Silver, Tony Halpin Education Editor, Daniel McGrory, Gary Duncan Economics Editor, Selwyn Goodacre, Dan Brennan, Alex Lee, John Westerby, Patrick Hosking Investment Editor, Martyn Palmer, Jill Sherman Whitehall Editor, Ann Treneman, Robert Carruthers, Andrew Pierce and Adam Fresco, Neil Harman Tennis Correspondent, Lewis Smith, Matthew Pryor, Sean MacAulay, Matt Dickinson, Jean Noble, John Nash, Steve Coomber, Kaveh Solhekol, Rosemary Bennett Deputy Political Editor, Jeremy Page, Caroline Merrell, Chris Campling, Patrick Hosking, Peter Dixon, Gabriel Rozenberg Economics Reporter, Clive Campling, Shebbear, David Hands Rugby Correspondent, Tony Cascarino, Kevin Maher, Julian Muscat, Mike Mulvihill, Michelle Henery, Nick Szczepanik, John Goodbody, Dominic Kennedy, James Doran, Richard Bristow, Jane Shilling, Andrew Cooper (Senior Chaplain), Carol Williamson, Mel Webb, Ian Johns, Roger Maynard and Richard Ford, Annie Kelly, Sophie Kirkham, Mike Rosewell, Nic Hopkins Stock Markets, Dileep Premachandran, Caitlin Moran, Neil Fisher, James and Barbara Wilson, Tony Dawe, Catherine Philp, Martin Waller, Chris Ayres, Nigel Hawkes Health Editor, John Plummer, Benedict Nightingale, Bill Edgar, Hilary Gilfoy, James Christopher, Leigh Singer, Abigail Rayner, Terence Conran, Brian Clarke Fishing Correspondent, Jenny Davey, Peter Klinger, Anthony Browne and Rory Watson, Christopher Irvine,
... I really do belive Satan is Interview Paul Schrader's Exorcist prequel was binned. Now it's been resurrected. James Christopher saw it Maria Full of Grace Tic off the old block ...
2005 - Gale Group | TDA
Ulrich Flögel, Sebastian Temme, Christoph Jacoby, Thomas Oerther, Petra Keul, Vera Flocke, Xiaowei Wang, Florian Bönner, Fabian Nienhaus, Karlheinz Peter, Jürgen Schrader, Maria Grandoch, Malte Kelm, Bodo Levkau,
Prediction of the transition from stable to acute coronary syndromes driven by vascular inflammation, thrombosis with subsequent microembolization, and vessel occlusion leading to irreversible myocardial damage is still an unsolved problem. Here, we introduce a multi-targeted and multi-color nanotracer platform technology that simultaneously visualizes evolving danger patterns in the development of progressive coronary inflammation and atherothrombosis prior to spontaneous myocardial infarction ...
Tópico(s): Lanthanide and Transition Metal Complexes
2021 - Nature Portfolio | Nature Communications
Ernest Jones, J. Cotterill, T. Ainsworth, S. Howarth, J. H. Powell, John Brown,
... A Happy Aristocratic Connexion, Lewis and Cooper V. Schrader—The Lady and the ... to Lydia Maria Child, Squaring the Circle, Denmark, Germany, Reform in ...
1859 - Gale Group | NCCO BritishPolitics
Claudia Schrader, Maria Reichelt, Steffi Zander,
Tópico(s): Innovative Teaching and Learning Methods
2018 - Springer Science+Business Media | Educational Technology Research and Development
Chris Peachment, Michael Moore, Anna Moore, P. W. Bryant, Country Planning Officer, Michael Syrett, Victoria McKee, Juan Carlos Gumucio, Michael Keall (Junior Bursar), Anne Billson, Richard Thomson, David Lee, David Rhys Jones, Robin Oakley, Simon Hughes, Philip Howard, John Bell, City Editor, Ian Murray, David Walker Public Administration Correspondent, Michael Binyon, Jeremy Kingston, James Bone, John Lewis Political Staff, Carol Leonard, Philip Webster and Richard Ford, Richard Eaton, Henry Gee, Yehudi Menuhin, Sam Kiley Higher Education Reporter, Mitchell Platts, Golf Correspondent, Peter Davenport, Michael Tate, John Lewis, Political Staff, Norman Hammond, Archaeology Correspondent, Peter Ball, T. Bain Smith, Anthony Grant, Jill Sherman, Social Services Correspondent, Jamie Dettmer, Irish Affairs Correspondent, Chris Pomery, Rodney Lord, Louise Taylor, Huon Mallalieu, Alexandra King, Michael Evans, Defence Correspondent, Alan Hamilton, Charles Byrne, Jenny MacArthur, Charles Bremner, John Percival, Edward Gorman, Conor Cruise O'Brien, D. A. H. Byatt, Stephen Thorpe Kingstown, George Rae, Sydney Friskin, Justus De Goede, Alec Kenny, Dennis Signy, Chris Thau, David Miller, Aleksandr Shaginyan, (Michael Phillips), Peter Dear and Jane Shilling, Celia Brayfield, Wolfgang Münchau, Brook Horowitz, Michael Horsnell and Peter Davenport, David Brewerton Executive Editor, Dennis Shaw, Raymond Keene, Chess Correspondent, Craig Brown, Kate Finch, Martin Trew, Richard Ford, Legal Affairs Reporter, Barry Pickthall, Richard Bassett, Keith MacKlin, Simon Tait, Arts Correspondent, Charles Knevitt, Architecture Correspondent, David Hands Rugby Correspondent, Harry J. Eves (Development Manager), Jamie Dettmer, David Brewerton, John Goodbody, Jane Bidder, N. E. Points, L. D. Points, Sam Kiley, Higher Education Reporter, Clive White, Matthew Parris, Sarah Jane Checkland Art Market Correspondent, Paul Harrison, Sallie Ecroyd, Jonathan Rendall, John Cox, ChairmanRICHARD Winward, Michael Clark and Geoffrey Foster, Dr Jim Riordan, Andrew Lycett, David Sinclair, Stephen Pettitt, Cliff Feltham, David Brewerton and Rodney Hobson, Noël Goodwin, Andrew McEwen and Mary Dejevsky, Philip Howard, Literary Editor, David Nicholson-Lord, Vivien Tomlinson, Derek Harris Industrial Editor, Steve Turner, Maria Scott, Colin Campbell, David Fallows, R. L. Marshall,
... on, charge! Chris Peachment meets film-maker Paul Schrader, whose Patty Heart opens here this week To ...
1989 - Gale Group | TDA
Stefan Schrader, Maria Notara, Stephen J. Tuft, Michèle Beaconsfield, Gerd Geerling, Julie T. Daniels,
To evaluate a serum-free system where mitotically active subconjunctival fibroblasts were co-cultured with conjunctival epithelial cells to mimic a niche environment for conjunctival progenitor cells.Human conjunctival epithelial cells were expanded in vitro and evaluated for their colony-forming efficiency and clonal ability. The cells were then transferred to a serum-free co-culture system and cultured in the presence of mitotically active subconjunctival fibroblasts (human conjunctival epithelial ...
Tópico(s): Immunotherapy and Immune Responses
2010 - Future Medicine | Regenerative Medicine
Andrew Robson, Dr Thomas Stuttaford Medical Briefing, (Dominic Walsh), Amanda Andrews, Simon Barnes Chief Sports Writer, Alyn Shipton, David Barrie Director, Andy Bull, Peter Lansley, Mark Souster, David McKirdy, Alexandra Frean Education Editor, Jenni Rutherford, Philip Howard, John Bunting, Hilary Finch, Jonny Wilkinson, Christine Seib, David Chater, Michael Binyon, Joanna Bale, James Bone, (Caroline Merrell), Dalya Alberege Arts Correspondent, Carol Sarler, Gabrielle Starkey, Patrick Kidd, Will Pavia, Sam Marlowe, Kevin Eason, Geoff Brown, Gemma Clarke, Joe Joseph, John Percy, Robin Pagnamenta, Martin Fletcher, Ben Webster Transport Correspondent, Antony Browne, Jane MacArtney, John Evans, Lewis Smith Science Reporter, (Martin Waller), Dominic Walsh, Rory Watson, Gary Jacob, Richard Ford Home Correspondent, Alan Hamilton, David Driver Head of design, Andy Stephens, Anatole Kaletsky Economic Briefing, Richard Lloyd Parry, Ron Lewis, Adam Sherwin Media Correspondent, Robert Skidelsky, Russell Kempson, Gary Duncan Economics Editor, Oliver Kay, Jane Wheatley, Mark Henderson Science Editor, Keveh Solhekol, James Harding Business Editor, Julian Evans, Rick Broadbent, Sir John Morgan, Jill Sherman Whitehall Editor, Christopher Martin-Jenkins, Pete Paphides, Alice Olins, Bernard Lagan, Neil Harman Tennis Correspondent, Raymond Keene, Ian Evans, Matthew Pryor, Matt Hughes, Rebecca O'Connor, Sean O'Neill, Dr Tanya Byron, Marcus Binney Architecture Correspondent, Jeremy Page, Caroline Merrell, Chris Campling, Bronwen Maddox, Simon Montague, Richard Owen, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Peter Dixon, Gabriel Rozenberg Economics Reporter, David Hands Rugby Correspondent, Richard Gregson, Tom Dart, Paul Simons, Nick Szczepanik, Philip Webster Political Editor, Tim Hames, Michele Kirsch, Peter Oppenheimer, Dominic Maxwell, Anthony Browne Chief Political Correspondent, Anjana Ahuja, Lorraine Parkin, George Caulkin, Caitlin Moran, Alan Lee, Anne Francis, Walter Gammie, Josh Ball, Kaven Solhekol, Rajeev Syal, David Sanderson, David Sinclair, Bojan Pancevski, Lewis Stuart, Mark Henderson, Martin Waller, Danny Baker, Amanda Andrews Media reporter, Mark Baldwin, Nigel Hawkes Health Editor, Benedict Nightingale, Louise Cohen, Rachel Campbell-Johnston Chief Art Critic, Dr Thomas Stuttaford, Richard Beeston and Michael Evans, Maria Ryan, Stephen Gardiner, Ben Hoyle, Stephen Dalton, David Powell, Pat Gibson and John Westerby, Alyson Rudd, Tony Halpin, Bill Edgar, Galway Kinnell, Owen Slot, Olav Bjortomt, Gerard Baker us Editor, Sacha Bonsor, Christopher Irvine, Lucina Ganderton,
... 15, 2006, aged 82 Lives in brief Leonard Schrader, film writer, was born on November 30, 1943. ...
2006 - Gale Group | TDA
Stefan Schrader, Maria Notara, Michèle Beaconsfield, Stephen J. Tuft, Gerd Geerling, Julie T. Daniels,
Transplantation of tissue-engineered conjunctival epithelial cell sheets has proven to be a promising technique for conjunctival reconstruction. The ability to cryopreserve conjunctival epithelial cells and maintain their stem cell population would improve their availability for clinical use. The aim of this study was to evaluate whether cryopreservation and long-term in vitro culture has an effect on the proliferative capacity and the progenitor-like cell characteristics of conjunctival epithelial ...
Tópico(s): Polydiacetylene-based materials and applications
2009 - Future Medicine | Regenerative Medicine
Stefan Schrader, Maria Notara, Michèle Beaconsfield, Stephen J. Tuft, Julie T. Daniels, Gerd Geerling,
Reconstruction of the conjunctiva is an essential part of ocular surface regeneration, especially if an extensive area or the whole ocular surface is affected, such as in patients with ocular cicatricial pemphigoid, Stevens-Johnson syndrome, toxic epidermal necrolysis, or chemical/thermal burns. In these situations, corneal reconstruction almost inevitably fails unless the conjunctival surface is first repaired and a deep fornix is restored. The growing field of tissue engineering and advances in ...
Tópico(s): Silk-based biomaterials and applications
2009 - Taylor & Francis | Current Eye Research
Marco Colleoni, Weixiu Luo, Per Karlsson, Jacquie Chirgwin, Stefan Aebi, Guy Jérusalem, Patrick Neven, Erika Hitre, Marie-Pascale Graas, Edda Simoncini, Claus Kamby, Alastair M. Thompson, Sibylle Loibl, Joaquín Gavilá, Katsumasa Kuroi, Christian Marth, Bettina Müller, Séamus O’Reilly, Vincenzo Di Lauro, Andrea Gombos, Thomas Ruhstaller, Harold J. Burstein, Karin Ribi, Jürg Bernhard, Giuseppe Viale, Rudolf Maibach, Manuela Rabaglio, Richard D. Gelber, Alan S. Coates, Angelo Di Leo, Meredith M. Regan, Aron Goldhirsch, A. Vandebroek, Martine Berlière, C. Mitine, Peter Vuylsteke, Marleen Borms, Randal D’hondt, Philippe Glorieux, Jeroen Mebis, Didier Verhoeven, Michael Coibion, Frédéric Forget, Lionel Duck, Didier Verhoeven, Wim Wyendaele, Annelore Barbeaux, Jean-Paul Salmon, Patrick Berteloot, Joanna Vermeij, Vincent R. Richard, Saverio Cinieri, Lorenzo Gianni, Mario Clerico, Graziella Pinotti, Antônio Bernardo, Laura Biganzoli, Alessandra Gennari, Claudio Graiff, Dino Amadori, Rodolfo Passalacqua, John Forbes, Prudence A. Francis, Serene S. Foo, Frances Boyle, Andrew Redfern, André van der Westhuizen, Craig Lewis, Sharad Sharma, Philip Beale, Ian Byard, Stephen Begbie, Frank Sardelic, Ehtesham Abdi, D.D. Clark, Aaron Chindewere, Stephen Della‐Fiorentina, Ray Asghari, Mohammed Islam, Lee Na Teo, Shane White, Linda Gilbert, Katherine Gardner, Catarina Uhlmann, Daniel Rauch, Meinrad Mannhart, Katharina Buser, Konstantin J. Dedes, Andreas Mueller, Christoph Rageth, Stephanie von Orelli, Hans Joerg Senn, Olivia Pagani, A Pedrazzini, Christoph Rochlitz, Alexandre Bodmer, Sandro Anchisi, Khalil Zaman, Roger von Moos, Daniel Betticher, Elena Kralidas, Răzvan Popescu, Mathias K. Fehr, Per Olof Nyman, Anja Jungquist, Chaido Chamalidou, Theodoros Foukakis, Charlotta Dabrosin, Antonis Valachis, Istvan Lang, Zsuzsanna Kahán, Javier Retamales, Ulloa Roberto Torres, Marcela Fritis, Sebastián Solé, Soledad Torres, Jaime Letzkus, Paula Escobar, Ines Vigneaux, Jorge Arancibia, Juana Bernardita Cardemil, Patricio Huidobro, Henry Gómez, Julie Wetter, Daniel Vorobiof, G. B. McMichael, Justus Apffelstaedt, И. К. Воротников, Joel Schwartz, Thomas H. Openshaw, Hervé Bonnefoi, Jean-Philippe Jacquin, Natalie Bonichon-Lamichhane, Simona Borstner, Ashwini Budrukkar, Marianne Ewertz, Oscar Zambrano Quispe, Peter Michael Vestlev, Hella Danø, Ditte Nielsen, Erik Jakobsen, Inger Hoejris, Jurij Bogovic, Britta Bjerregaard Jensen, Knud Aage Møller, Eric Lars Stenbygaard, Ravi Sharma, C. Bedi, Maria Bews-Hair, Glyn Neades, Mike McKirdy, Matthew Barber, Abdulla Alhasso, Diana Ritchie, Judith Fraser, Lucy Scott, Frances Yuille, Alison Lannigan, Dermot Murphy, Mike Shere, Christian Jackisch, Oliver Tomé, S Steer, Doris Augustin, Kristina Lübbe, Christian Jackisch, Heike Köcker-Korus, Jörg-Uwe Deuker, Andrea Stefek, Marianne Just, Uwe Rhein, Christina Bechtner, Dirk-Toralf Baerens, Iris Schrader, Eva‐Maria Grischke, Ralf Lorenz, Wolfgang Dietz, Jörg Thomalla, Jörg Schilling, A. Rempen, Heiko Graf, Gabriele Doering, Steffi Busch, Georg Heinrich, Hans Tesch, Christoph Uleer, Petra Krabisch, Siegfried Rösel, Christian M. Kurbacher, Horst Ostertag, Klaus-M Josten, Carsten Hielscher, Isolde Gröll, Ute Marie Mattner, A. Prechtl, Tilmann Lantzsch, Eva Ciruelos, Isabel Garau, Meritxell Bellet, Miguel Ángel Climent, Rafael López‐López, Juan Antonio Virizuela, Begoña Bermejo, Noelia Martínez-Jáñez, Kepa Amillano, Raúl Márquez, Joan Dorca, María José Godes, Santiago González, Shinji Ohno, Tomoyuki Aruga, Daisuke Yotsumoto, Yutaka Yamamoto, Tomohiko Aihara, Takashi Morimoto, Hiroko Bando, Norikazu Masuda, Masakazu Toi, Kenjiro Aogi, Nobuaki Sato, Morihito Okada, Masato Takahashi, Eriko Tokunaga, Hiroji Iwata, Takashi Fujita, Michael Fridrik, Gunda Pristauz, Claudia Hackl, Christian F. Singer, V. Wette, Michael Gnant, Josef Thaler, Richard Greil, Burghard Abendstein, Dietmar Heck, D. Manfreda, P. Sevelda, I. Thiel, F Tuttlies, Herbert Stöger, W. Neunteufel, John Crown, John Kennedy, Arnold Hill, John McCaffrey, Conleth G. Murphy, Linda Coate, Maccon Keane, Michael J. Martin, Miriam O’Connor, Karen Duffy, Barbara Ruepp, Martine Piccart, Dimitrios Zardavas,
Background In animal models of breast cancer, resistance to continuous use of letrozole can be reversed by withdrawal and reintroduction of letrozole. We therefore hypothesised that extended intermittent use of adjuvant letrozole would improve breast cancer outcome compared with continuous use of letrozole in postmenopausal women. Methods We did the multicentre, open-label, randomised, parallel, phase 3 SOLE trial in 240 centres (academic, primary, secondary, and tertiary care centres) in 22 countries. ...
Tópico(s): Advanced Breast Cancer Therapies
2017 - Elsevier BV | The Lancet Oncology
Yvonne Klaile, Katrin Schlack, Martin Boegemann, Julie Steinestel, Andres J. Schrader, Laura‐Maria Krabbe,
Abstract: Bladder cancer (BC) is a frequent type of carcinoma with an estimated incidence of approximately 100,000 men and women each year in the European Union (EU) with an associated mortality of 30,000 of these patients. In more than 70% the disease is diagnosed in a non-muscle invasive stage with the chance of minimally invasive, local treatment only, which might be required repetitively due to high rate of recurrence. In contrast, muscle invasive or metastatic stages need multimodal treatment ...
Tópico(s): Infectious Disease Case Reports and Treatments
2016 - AME Publishing Company | Translational Andrology and Urology
Produção Nacional
Revisado por pares
Luiz Guilherme Martins Castro, Renato Marchiori Bakos, João Pedreira Duprat Neto, Flávia Vasques Bittencourt, Thais Helena Bello Di Giacomo, Sérgio Schrader Serpa, Maria Cristina de Lorenzo Messina, Walter Refkalefsky Loureiro, Ricardo Macarenco, Hamílton Ometto Stolf, Gabriel Gontijo,
The last Brazilian guidelines on melanoma were published in 2002. Development in diagnosis and treatment made updating necessary. The coordinators elaborated ten clinical questions, based on PICO system. A Medline search, according to specific MeSH terms for each of the 10 questions was performed and articles selected were classified from A to D according to level of scientific evidence. Based on the results, recommendations were defined and classified according to scientific strength. The present ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2016 - Elsevier BV | Anais Brasileiros de Dermatologia
Katrin Schlack, Martin Boegemann, Julie Steinestel, Andres J. Schrader, Laura‐Maria Krabbe,
Bladder cancer is a common type of cancer with an estimated incidence of more than 70,000 patients and had a mortality of 16,000 patients in the US in 2015. In more than 70% of cases the disease is diagnosed at the non-muscle invasive stage. However, muscle invasive or metastatic stages need multimodal treatment strategies including surgical treatment and chemotherapy in a neoadjuvant, adjuvant or palliative setting. Gemcitabine is a pyrimidine antimetabolite that has shown efficacy when used systemically ...
Tópico(s): Viral-associated cancers and disorders
2016 - Taylor & Francis | Expert Review of Anticancer Therapy
Martin Boegemann, Katrin Schlack, Ann-Kathrin Fischer, Joachim Gerß, Julie Steinestel, Axel Semjonow, Andres J. Schrader, Laura‐Maria Krabbe,
Even though the exact mechanism is largely unknown until now, statins are supposed to improve survival outcomes in various malignancies. For prostate cancer however, statins are known to compete with dehydroepiandrosterone (DHEAS) for the transport into the cytosol both using the cell by the Solute Carrier Transporter and thus diminish the cellular uptake of DHEAS as a precursor of androgens. Abiraterone inhibits CYP17A1 and thus effectively decreases the production of all relevant androgens including ...
Tópico(s): Lipoproteins and Cardiovascular Health
2016 - Public Library of Science | PLoS ONE
Martin Boegemann, Andres-Jan Schrader, Laura‐Maria Krabbe, Edwin Herrmann,
Introduction: Recently, an increasing number of systemic therapies with life extending capacity have become available in metastatic castration resistant prostate cancer (mCRPC) i.e. Abiraterone acetate, Enzalutamide, Sipuleucel-T, Docetaxel, Cabazitaxel and Radium-223. More compounds are currently being evaluated in promising pivotal trials (e.g. Tasquinimod, ARN-509, ODM-201, and more). Limitations of the currently available biomarkers make treatment decisions challenging. Considering the ever increasing ...
Tópico(s): Estrogen and related hormone effects
2015 - Bentham Science Publishers | Current Cancer Drug Targets
Markus Krumbholz, Diethilde Theil, Tobias Derfuß, Andreas Rosenwald, Frank Schrader, Camelia‐Maria Monoranu, Susan L. Kalled, Donna M. Hess, Barbara Serafini, Francesca Aloisi, Hartmut Wekerle, Reinhard Hohlfeld, Edgar Meinl,
We report that B cell–activating factor of the tumor necrosis factor (TNF) family (BAFF) is expressed in the normal human brain at ∼10% of that in lymphatic tissues (tonsils and adenoids) and is produced by astrocytes. BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. Cultured human astrocytes secreted functionally active BAFF after stimulation with interferon-γ and TNF-α via a furin- ...
Tópico(s): Immunotherapy and Immune Responses
2005 - Rockefeller University Press | The Journal of Experimental Medicine
Pascal Bouvain, Zhaoping Ding, Shiwa Kadir, Patricia Kleimann, Nils Kluge, Zeynep-Büsra Tiren, Bodo Steckel, Vera Flocke, Ria Zalfen, Patrick Petzsch, Thorsten Wachtmeister, John C. Gordon, Nirojah Subramaniam, Wolfgang Krämer, Tobias Strasdeit, Mehrnaz Mehrabipour, Jens M. Moll, Rolf Schubert, Mohammad Reza Ahmadian, Florian Bönner, Udo Boeken, Ralf Westenfeld, Daniel R. Engel, Malte Kelm, Jürgen Schrader, Karl Köhrer, Maria Grandoch, Sebastian Temme, Ulrich Flögel,
Neutrophils play a complex role during onset of tissue injury and subsequent resolution and healing. To assess neutrophil dynamics upon cardiovascular injury, here we develop a non-invasive, background-free approach for specific mapping of neutrophil dynamics by whole-body magnetic resonance imaging using targeted multimodal fluorine-loaded nanotracers engineered with binding peptides specifically directed against murine or human neutrophils. Intravenous tracer application before injury allowed ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2023 - Nature Portfolio | Nature Cardiovascular Research
Sophie Schrader, Andreas Westhoff, Maria Carla Piastra, Tuuli Miinalainen, Sampsa Pursiainen, Johannes Vorwerk, Heinrich Brinck, Carsten H. Wolters, Christian Engwer,
Accurate and efficient source analysis in electro- and magnetoencephalography using sophisticated realistic head geometries requires advanced numerical approaches. This paper presents DUNEuro, a free and open-source C++ software toolbox for the numerical computation of forward solutions in bioelectromagnetism. Building upon the DUNE framework, it provides implementations of modern fitted and unfitted finite element methods to efficiently solve the forward problems of electro- and magnetoencephalography. ...
Tópico(s): Wireless Body Area Networks
2021 - Public Library of Science | PLoS ONE
Karla Eggert, Christoph Schrader, Michaela Hahn, María Stamelou, Anne Rüssmann, Reinhard Dengler, Wolfgang H. Oertel, Per Odin,
Objectives: We report here on the experience with continuous jejunal levodopa infusion in 13 German parkinsonian patients who have motor and nonmotor complications despite individually optimized oral treatment. The tolerability, efficacy, and the need for dose adjustment of levodopa infusion were followed-up prospectively. Thereby, we describe clinically relevant details for how to successfully initiate and handle this new treatment strategy. Methods: Thirteen patients with advanced Parkinson disease ( ...
Tópico(s): Restless Legs Syndrome Research
2008 - Lippincott Williams & Wilkins | Clinical Neuropharmacology
Luigi Ippolito, Alberto Marini, Lorenzo Cavallini, Andrea Morandi, Laura Pietrovito, Gianfranco Pintus, Elisa Giannoni, Thomas Schräder, Martin Puhr, Paola Chiarugi, Maria Letizia Taddei,
... Gianfranco Pintus 5, 6 , Elisa Giannoni 1 , Thomas Schrader 2 , Martin Puhr 3 , Paola Chiarugi 1, 4, * , Maria Letizia Taddei 7, * 1 Department of Experimental and ...
Tópico(s): Cancer, Lipids, and Metabolism
2016 - Impact Journals LLC | Oncotarget
Roberto C. Arduino, Esteban C. Nannini, Maria Rodriguez- Barradas, Shannon Schrader, Marcelo Losso, Kiat Ruxrungtham, Maria C. Allende, Sean Emery, Lisa Fosdick, James D. Neaton, Jorge A. Tavel, Richard T. Davey, H. Clifford Lane,
In advance of a large clinical end point trial evaluating the effectiveness of subcutaneous interleukin 2 (scIL-2) for treatment of patients with human immunodeficiency virus (HIV) infection, 3 identically designed Vanguard trials were conducted in Buenos Aires, Argentina; Bangkok, Thailand; and Houston, Texas. To more precisely quantitate the effect on CD4 cell response of 3 different doses of scIL-2 that were administered twice daily for 5 days every 8 weeks, the results of these 3 trials were pooled ...
Tópico(s): Immunotherapy and Immune Responses
2004 - Oxford University Press | Clinical Infectious Diseases
B. Schrader, Anna-Maria Bünker, Charis Conradi, Stephan Lüders, Bernhard Vaske, Michael Koziolek, Hermann Haller, Albrecht Elsässer, Joachim Schrader,
It is well documented that insufficient physical activity (PA) contributes substantially to cardiovascular diseases. The number of physically active people in Germany is still too low.In ELITE study in Germany, 4602 participants are regularly examined for cardiovascular risk factors (CVRF). The aim is to motivate participants to improve their CVRF through individual recommendations and regular follow-up. Here, the PA data are presented in correlation with CVRF at baseline. A feature of this presentation ...
Tópico(s): Cardiac Health and Mental Health
2022 - Dove Medical Press | International Journal of General Medicine
Produção Nacional
Revisado por pares
Greice Schrader, Sofia Palagi, Maria Angélica Silveira Padilha, Patrícia Tuerlinckx Noguez, Maíra Buss Thofehrn, Daiane Dal Pai,
Objetivou-se conhecer a percepção dos enfermeiros que atuam nas unidades básicas de saúde de Pelotas, Rio Grande do Sul, sobre a sua qualidade de vida no trabalho (QVT). Tratou-se de estudo qualitativo, exploratório e descritivo, realizado com sete enfermeiros por meio de entrevistas semiestruturadas. As falas dos participantes foram submetidas à análise temática. Condições inadequadas para o trabalho, desvalorização profissional e suporte insuficiente dos gestores foram categorias relacionados à ...
Tópico(s): Workplace Health and Well-being
2012 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Carlos M. Baeza, O. Schrader, Eduardo Ruíz, María A. Negritto,
A B S T R A C T Alstroemeria (Alstroemeriaceae) is an endemic genus of South America with two major distribution centers in the continent: Chile and Brazil. In Chile the genus is distributed from the North, near Iquique (20o13’ S, 70o09’ W) to the Chilean and Argentine Patagonia (53o10’ S, 70o54’ W). The central zone of Chile presents the highest number of species. A. presliana Herb. grows from Curico (34o59’ S, 71o14’ W) to Cautin (38o45’ S, 72o34’ W) in Chile and Neuquen (36o50’ S, 71o05’ W), Argentina. ...
Tópico(s): Plant and animal studies
2008 - Instituto de Investigaciones Agropecuarias, INIA | Chilean journal of agricultural research
Christian Görgens, Anja Patricia Ramme, Sven Guddat, Yvonne Schrader, Annika Winter, Eva‐Maria Dehne, Reyk Horland, Mario Thevis,
A fundamental challenge in preventive doping research is the study of metabolic pathways of substances banned in sport. However, the pharmacological predictions obtained by conventional in vitro or in vivo animal studies are occasionally of limited transferability to humans according to an inability of in vitro models to mimic higher order system physiology or due to various species-specific differences using animal models. A more recently established technology for simulating human physiology is ...
Tópico(s): Hormonal and reproductive studies
2021 - Wiley | Drug Testing and Analysis
Martin Boegemann, Katrin Schlack, Stefan Thomes, Julie Steinestel, Kambiz Rahbar, Axel Semjonow, Andres J. Schrader, Martin Aringer, Laura‐Maria Krabbe,
The purpose of this study was to examine the prognostic capability of baseline neutrophil-to-lymphocyte-ratio (NLR) and NLR-change under Abiraterone in metastatic castration-resistant prostate cancer patients. The impact of baseline NLR and change after eight weeks of treatment on progression-free survival (PFS) and overall survival (OS) was analyzed using Kaplan-Meier-estimates and Cox-regression. 79 men with baseline NLR 5 were analyzed. In baseline analysis of PFS NLR >5 was associated with non-significantly ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2017 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Stephen O. Duke, Franck E. Dayan, Agnes M. Rimando, Kevin K. Schrader, Giovanni Aliotta, Anna Maria Oliva, Joanne G. Romagni,
Natural products represent a vast repository of materials and compounds with evolved biological activity, including phytotoxicity. Some of these compounds can be used directly or as templates for herbicides. The molecular target sites of these compounds are often unique. Strategies for the discovery of these materials and compounds are outlined. Numerous examples of individual phytotoxins and crude preparations with weed management potential are provided. An example of research to find a natural ...
Tópico(s): Plant-derived Lignans Synthesis and Bioactivity
2002 - Cambridge University Press | Weed Science
B. Schrader, Joachim Schrader, Albrecht Elsässer, Anna-Maria Bünker, Berit Hillmann, Bernhard Vaske, Hermann Haller, Stephan Lüders,
Background: In ELITE (Ernährung, Lebensstil und individuelle Information zur Verhinderung von Herzinfarkt, Schlaganfall und Demenz; german for: Nutrition, Lifestyle and Individual Information for the Prevention of Heart Attack, Stroke and Dementia) data on cardiovascular risk factors, cognitive function and quality of life are prospectively collected, which will be improved through targeted individual information. The aim is to improve the health of the participants and identify the reasons for the ...
Tópico(s): Dementia and Cognitive Impairment Research
2020 - Lippincott Williams & Wilkins | Journal of Hypertension
Jürgen Schrader, D.G.A.B. Oonincx, Maria Pontes Ferreira,
Eating insects is not a common Northern American practice today. However, in the past a variety of insect species was consumed in Northern America (north of Mexico including Greenland). The aim of this literature review is to provide an historical overview of North American entomophagy based upon both peer and non-peer reviewed sources on this topic. Regional differences in insect consumption and reasons for being underreported are discussed. We show that North American natives, and in certain cases ...
Tópico(s): Neurobiology and Insect Physiology Research
2016 - | Journal of Insects as Food and Feed
Nelson Ferreira, Alda Pereira-Henriques, Aida Attar, Frank‐Gerrit Klärner, Thomas Schräder, Gal Bitan, Luı́s Gales, Maria João Saraiva, Maria Rosário Almeida,
Transthyretin (TTR) amyloidoses comprise a wide spectrum of acquired and hereditary diseases triggered by extracellular deposition of toxic TTR aggregates in various organs. Despite recent advances regarding the elucidation of the molecular mechanisms underlying TTR misfolding and pathogenic self-assembly, there is still no effective therapy for treatment of these fatal disorders. Recently, the "molecular tweezers", CLR01, has been reported to inhibit self-assembly and toxicity of different amyloidogenic ...
Tópico(s): Cellular transport and secretion
2014 - Springer Science+Business Media | Neurotherapeutics