Maria Elena Remoli, Elena Giacomini, Elisa Petruccioli, Valérie Gafa, Martina Severa, Maria Cristina Gagliardi, Elisabetta Iona, Richard Pine, Roberto Nisini, Eliana M. Coccia,
Mycobacterium tuberculosis (Mtb) evades the immune response by impairing the functions of different antigen‐presenting cells. We have recently shown that Mtb hijacks differentiation of monocytes into dendritic cells (DCs). To further characterize the mechanisms underlying this process, we investigated the consequences of inducing dendritic cell differentiation using interferon‐α and granulocyte‐macrophage colony‐stimulating factor in the presence of supernatants (SNs) obtained from monocyte cultures ...
Tópico(s): Immunotherapy and Immune Responses
2010 - Wiley | Immunology and Cell Biology
Martina Severa, Maria Elena Remoli, Elena Giacomini, Viviana Annibali, Valérie Gafa, Roberto Lande, Mark A. Tomai, Marco Salvetti, Eliana M. Coccia,
Abstract TLRs interact with a growing list of pathogen-derived products and these interactions drive the activation of innate and adaptive immune responses. Dendritic cells (DC) play a key role in these events expressing a heterogeneous repertoire of TLRs. We have previously demonstrated the production of type I IFNs in DC following bacterial infections and TLR triggering. In this study, we sought to characterize the transcriptome specifically induced in human DC by IFN-β production stimulated upon ...
Tópico(s): NF-κB Signaling Pathways
2007 - American Association of Immunologists | The Journal of Immunology
Martina Severa, Maria Elena Remoli, Elena Giacomini, Josiane Ragimbeau, Roberto Lande, Gilles Uzé, Sandra Pellegrini, Eliana M. Coccia,
Abstract In human monocyte-derived dendritic cells (DC), infection with Mycobacterium tuberculosis and viruses or stimulation with Toll-like receptor type 3 and 4 agonists causes the release of type I interferon (IFN). Here, we describe that the IFN-β released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such ...
Tópico(s): Immune Cell Function and Interaction
2006 - Oxford University Press | Journal of Leukocyte Biology
Elena Giacomini, Ambar Sotolongo, Elisabetta Iona, Martina Severa, Maria Elena Remoli, Valérie Gafa, Roberto Lande, Lanfranco Fattorini, Issar Smith, Riccardo Manganelli, Eliana M. Coccia,
The Mycobacterium tuberculosis genome encodes 13 sigma factors. We have previously shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and can attenuate the virulence phenotype. In this work, we focused on extracytoplasmic factor sigmaE and studied the effects induced by the deletion of its structural gene (sigE) in the infection of human monocyte-derived dendritic cells (MDDC). We found that the wild-type M. tuberculosis ...
Tópico(s): Immunotherapy and Immune Responses
2006 - American Society for Microbiology | Infection and Immunity
Arlene Caban, Elizabeth A. Walker, Severa Sanchez, Maria S. Mera,
Background. Studies on Hispanics/Latinos with diabetes have largely focused on Mexican-American populations. This qualitative study explored psychosocial issues that affect diabetes self-management for Hispanic men and women of primarily Caribbean ancestry. Methods. Thirty-seven adults with diabetes in Bronx, N.Y., were recruited to seven focus groups, which were conducted in Spanish and English,audiotaped, transcribed, and subjected to qualitative analysis. Results. New themes emerged that are ...
Tópico(s): Obesity and Health Practices
2008 - American Diabetes Association | Diabetes Spectrum
Valérie Gafa, Roberto Lande, Maria Cristina Gagliardi, Martina Severa, Elena Giacomini, Maria Elena Remoli, Roberto Nisini, Carlo Ramoni, Paolo Di Francesco, Delphine Aldebert, R. Grillot, Eliana M. Coccia,
Aspergillus fumigatus is the most prevalent airborne fungal pathogen and causes fatal invasive aspergillosis in immunocompromised patients. Given the essential role of dendritic cells (DC) in initiating and regulating immune responses, we investigated the impact of A. fumigatus conidial infection on human DC. A. fumigatus conidia were rapidly internalized and induced the release of tumor necrosis factor alpha within the first 8 h. After A. fumigatus infection, the majority of DC underwent full maturation, ...
Tópico(s): Infectious Diseases and Mycology
2006 - American Society for Microbiology | Infection and Immunity
Gerson A. Salcedo-Rivera, José A. Fuentes-Mario, José Tovar-Márquez, Luis Fernando Crespo Montes, César Rojano, Leonardo Arias-Bernal, José F. González‐Maya,
Durante los días 5 y 9 de abril de 2018, entre las 17h00 y 18h00 aproximadamente, se realizaron avistamientos de un individuo macho aislado con signos compatibles con acariasis severa en la misma localidad (9°31ʼ47,215ˮN-75°21ʼ06,185ˮW; 165,7 msnm; Figura 1). Durante la primera observación, el individuo se encontró dentro de una oquedad formada entre un tronco caído (Fabaceae) y el suelo; posteriormente se le vio dentro de un lugar con alto crecimiento herbáceo y se denotó dificultad para el movimiento. ...
Tópico(s): Animal Behavior and Welfare Studies
2018 - | Mammalogy Notes
María Ángeles Jiménez-Fuentes, Joaquim Gea, Oriol Pallàs, Ferrán Gallego, M A Félez, J.M. Broquetas,
Las características generales de la morfometría del músculo intercostal externo (IE) de pacientes con patología respiratoria crónica han sido ampliamente descritas. Por su accesibilidad, este músculo puede ser un modelo ideal en estudios longitudinales utilizando biopsias consecutivas de ambos lados. Sin embargo, se desconoce si existe o no homogeneidad en el fenotipo fibrilar del IE entre el lado dominante (D) y el no dominante (ND). Se han evaluado las posibles diferencias estructurales del IE entre ...
Tópico(s): Medical research and treatments
1998 - Elsevier BV | Archivos de Bronconeumología
Eliana M. Coccia, Martina Severa, Elena Giacomini, Danièle Monneron, Maria Elena Remoli, Ilkka Julkunen, Marina Cella, Roberto Lande, Gilles Uzé,
Abstract In humans, the type I interferon (IFN) family consists of 13 IFN‐α subtypes, IFN‐β and IFN‐o the newly discovered IFN‐like family consists of IFN‐λ1, ‐λ2 and ‐λ3. We have investigated the expression of type I and λ IFN genes following virus infections or Toll‐like receptor (TLR) triggering in monocyte‐derived DC (MDDC) and plasmacytoid DC (pDC). We found thatall IFN‐α, ‐β, ‐o and ‐λ subtypes are expressed in influenza‐virus‐infected MDDC or pDC. Conversely, differential type I IFN gene transcription ...
Tópico(s): T-cell and B-cell Immunology
2004 - Wiley | European Journal of Immunology
Roberto Lande, Valérie Gafa, Barbara Serafini, Elena Giacomini, Andrea Visconti, Maria Elena Remoli, Martina Severa, Marc Parmentier, Giovanni Ristori, Marco Salvetti, Francesca Aloisi, Eliana M. Coccia,
The roles of plasmacytoid dendritic cells (pDCs) and their response to interferon (IFN)-β therapy in multiple sclerosis (MS) patients are poorly understood. We identified pDC accumulation in white matter lesions and leptomeninges of MS brains and abundant expression of the Type I IFN-induced protein MxA, mainly in perivascular CD3+ lymphocytes in lesions, indicating Type I IFN production by activated pDCs. The pDC chemoattractant chemerin was detected in intralesional cerebrovascular endothelial cells, ...
Tópico(s): T-cell and B-cell Immunology
2008 - Oxford University Press | Journal of Neuropathology & Experimental Neurology
Verónica Hernández, María José Caño, Pilar Escribano, Miguel A. Gómez Sánchez,
Detection of pulmonary artery aneurysms (PAA) in pulmonary arterial hypertension (PAH) is increasing. We sought to determine the frequency of PAA in a PAH cohort, variables related to its development and its prognostic impact. We conducted a retrospective analysis of PAH patients who underwent a computed tomography or magnetic resonance. PAA was defined as a pulmonary artery >40 mm. Baseline, echocardiographic, and hemodynamic findings at PAH diagnosis were compared. Freedom from death or lung transplant ...
Tópico(s): Trauma Management and Diagnosis
2010 - Elsevier BV | Revista Española de Cardiología
Produção Nacional
Revisado por pares
Maria Helena Hasselmann, Cláudia S. Lopes, Michael Eduardo Reichenheim,
INTRODUÇÃO: Como parte do programa de investigação sobre violência familiar e desnutrição severa na infância, especificamente um estudo do tipo caso-controle foi avaliada a confiabilidade dos instrumentos utilizados no processo de obtenção de dados. Estudou-se a confiabilidade de quatro componentes do instrumento principal: (a) as Escalas sobre Táticas de Conflitos (Conflicts Tactics Scales - CTS) que medem o grau de conflito/violência familiar; (b) o instrumento CAGE (Cut-down; Annoyed; Guilty & Eye-opener) ...
Tópico(s): Resilience and Mental Health
1998 - UNIVERSIDADE DE SÃO PAULO | Revista de Saúde Pública
Luca Lacitignola, Pasquale De Luca, Rossella Santovito, Maria Severa Di Comite, Antonio Crovace,
Nutritional secondary hyperparathyroidism (NSH) is uncommon in horses. Aim of this report is evaluate an alternative therapeutic approach and provide more information on the diagnostic procedures, through detailed microscopic findings of the bone lesions pony with NSH. Administration of tiludronate along with a balanced diet can be used in a treatment protocol for ponies with NSH. This case report suggests that tiludronate can be used to ameliorate the clinical signs of NSH.
Tópico(s): Parathyroid Disorders and Treatments
2018 - University of Tripoli | Open Veterinary Journal
Labibe do Socorro Haber de Menezes, Vera Regina Palácios, Maria Severa Alcântara, Cléa Nazaré Carneiro Bichara,
Tópico(s): Cytomegalovirus and herpesvirus research
2012 - | Jornal Brasileiro de Doenças Sexualmente Transmissíveis
Luciana Orlando, Laura Maria Michetti, Barbara Belelli Marchesini, Paolo Papeschi, Fabio Giannino,
Abstract The Etruscan site of Pyrgi extended over 10 ha along the Tyrrhenian coastline. Fieldwork has so far brought to light the sanctuary and a ceremonial complex at the southern edge of the settlement, whereas additional evidence is provided by a section cut by sea erosion across the site. The archaeological layer is about 2 m thick and includes dry masonry buildings arranged into lots; the most superficial features are disturbed by deep agricultural activities and the top layer includes scattered ...
Tópico(s): Geophysical and Geoelectrical Methods
2019 - Wiley | Archaeological Prospection
María Del Pilar Valdés A., Francisca Schroeder H, Vicky Roizen G, Juan Honeyman M, Leonardo Sánchez M,
Efficacy of infliximab in patients with moderate and severe psoriasis treated with infliximab (Remicade ® )Background: Psoriasis has a moderate or severe course in 25% of patients, requiring systemic therapy that is not always successful.Infliximab is a human-murine monoclonal anti tumor necrosis alpha (TNF-α) antibody.This mediator has a role in the pathogenesis of psoriasis.Aim: To evaluate the use of infliximab in psoriatic patients resistant to conventional therapies.Material and Methods: An open ...
Tópico(s): Dermatology and Skin Diseases
2006 - Q16635223 | Revista médica de Chile
Nazaret María Pizarro Vega, P. Valer López-Fando, Gema de la Poza Gómez, Belén Piqueras Alcol, Marina Gil Santana, Paloma Ruiz Fuentes, Marcos Alfredo Rodríguez Amado, Fernando Bermejo San José,
Tópico(s): Kawasaki Disease and Coronary Complications
2022 - Elsevier BV | Gastroenterología y Hepatología
Eva María Rodríguez Gómez, F. Gómez, M. J. Merino, Angélica Natalia Montañez Robledo, J M López Domínguez, F. Girón, J. González Martínez,
espanolLa leucoencefalopatia posterior reversible es una alteracion del sistema nervio- so central que cursa clinicamente con cefalea, nauseas y vomitos, alteraciones vi- suales, disminucion del nivel de conciencia, crisis convulsivas y ocasionalmente signos de focalidad neurologica. Suele asociarse con hipertension arterial malig- na, toxemia del embarazo o el uso de inmunosupresores. Son fundamentales un diagnostico precoz y tratamiento adecuado. Se presenta un caso de leucoencefa- lopatia posterior ...
Tópico(s): Brain Metastases and Treatment
2001 - Elsevier BV | Nefrología
Françesc Formiga, María José Robles, Isabel Fort-Gallifa,
Because of the aging population, the incidence and prevalence of dementia has increased. The most common form of dementia is Alzheimer's disease. The present review focuses on the progression and prognosis of this disease, although many of the issues discussed can be extrapolated to other types of dementia. Despite public education efforts in recent years, dementia continues to have a tremendous impact on the patient, the primary caregiver and/or family and society in general. A diagnosis of dementia ...
Tópico(s): Frailty in Older Adults
2009 - Elsevier BV | Revista Española de Geriatría y Gerontología
Angela Pia Cazzolla, Vincenzo Brescia, Roberto Lovero, Antonietta Fontana, Arcangela Giustino, Mario Dioguardi, Maria Severa Di Comite, Francesca Di Serio, Domenico Ciavarella, Vito Crincoli,
The aim of this study was to evaluate changes in the concentration of N-terminal type I collagen extension pro-peptide (PINP), tartrate-resistant acid phosphatase (TRAcP), and parathyroid hormone-related protein (PTHrP) in saliva during orthodontic treatment in order to evaluate whether changes in bone turnover marker (BTM) concentration can help highlight the effects of orthodontic mechanical loading in the absence of clinical evidence of tooth movement in terms of tooth movement. Saliva samples from ...
Tópico(s): Oral microbiology and periodontitis research
2024 - Multidisciplinary Digital Publishing Institute | Dentistry Journal
Lucía Dolores Martínez González, María Teresa Robles Rendón, Bertha Ramos del Río, Fredy Santiesteban Macario, Ma. Elena García Valdés, M G Enriquez, Laura García Leaños,
Cerebral Palsy is defined as a motion disorder which affects both position and corporal movement due to a cerebral alteration during the encephalon’s development. Those patients who suffer cerebral palsy might require a caregiver, who is the person that takes care of all the activities the patient cannot perform by itself and takes responsibility for their treatment and wellbeing. The purpose of the study was to determine work perceived by the Primary Informal Family Caregiver (PIFC) of Cerebral ...
Tópico(s): Cerebral Palsy and Movement Disorders
2008 - | Revista Mexicana de Medicina Física y Rehabilitación
Ángel M. Alonso Gómez, María C. Belló Mora, Fernando Arós Borau, Alfonso Torres Bosco, J B Martinez Ferrer, Ignacio Camacho Azcargorta,
Exercise in mitral stenosis produces an increase in cardiac output and heart rate which determines the increment in the transmitral gradient. However, it has not yet been established what level is reached by the gradients on exercise in severe mitral stenosis nor whether the rise in the gradient during such exercise is different to that occurring in non-severe stenosis.To evaluate the effect of exercise in patients with severe mitral stenosis on the mitral valve gradients in absolute values and ...
Tópico(s): Cardiac Imaging and Diagnostics
1997 - Elsevier BV | Revista Española de Cardiología
Produção Nacional
Revisado por pares
Estela Maris Losso, Maria Cristina R. Tavares, Juliana Y. B. da Silva, Cı́cero de Andrade Urban,
OBJETIVO: Fornecer informações para auxiliar o médico pediatra a reconhecer os fatores de risco para o início da cárie precoce na infância e da cárie severa na infância (CSI), possibilitando a intervenção precoce de tais fatores, e, assim, evitar a instalação dessa doença prevenível e as suas consequências. FONTES DOS DADOS: As informações foram coletadas a partir de artigos científicos publicados nas bases de dados SciELO, MEDLINE e PUBMED nos últimos 25 anos, livros técnicos e publicações de consenso ...
Tópico(s): Dental Research and COVID-19
2009 - Elsevier BV | Jornal de Pediatria
DARWIN IÑAGUAZO S, MARÍA J ASTUDILLLO A,
Tópico(s): Intraperitoneal and Appendiceal Malignancies
2009 - Elsevier BV | Revista Chilena de Cirugía
Laura Férriz Romeral, María Patricia Navas, José Antonio Gómez Fraguela, Jorge Sobral Fernández,
35 (p < .001). Se estableció un modelo predictivo con una única variable moderadora: el tipo de delito, mostrando que la importancia de la desconexión moral aumenta notablemente cuando se incrementa la gravedad del delito (r = .45,p < .001).Se concluye que la tendencia a la desconexión moral puede considerarse como un factor de riesgo relevante para la delincuencia juvenil y más relevante todavía en relación con delitos graves.Este resultado contribuye a consolidar a las dimensiones morales como un factor ...
Tópico(s): Social Issues and Policies in Latin America
2019 - Konrad Lorenz Fundación Universitaria | Revista Latinoamericana de Psicología
Fabiana Rizzo, Elena Giacomini, Rosella Mechelli, Maria Chiara Buscarinu, Marco Salvetti, Martina Severa, Eliana M. Coccia,
Growing evidences put B lymphocytes on a central stage in multiple sclerosis (MS) immunopathology. While investigating the effects of interferon‐β (IFN‐β) therapy, one of the most used first‐line disease‐modifying drugs for the treatment of relapsing‐remitting MS, in circulating B‐cell sub‐populations, we found a specific and marked decrease of CD27 + memory B cells. Interestingly, memory B cells are considered a population with a great disease‐driving relevance in MS and resulted to be also target ...
Tópico(s): T-cell and B-cell Immunology
2016 - Wiley | Immunology and Cell Biology
Valérie Gafa, Maria Elena Remoli, Elena Giacomini, Martina Severa, R. Grillot, Eliana M. Coccia,
Although data show the importance of type I interferons (IFNs) in the regulation of the innate and adaptive immunity elicited in response to viral, bacterial and parasitic infections, the functional activities of these cytokines during fungal infections are poorly understood. We examined here the impact of IFN-β on the response of human monocyte-derived dendritic cells (DCs) infected in vitro with Aspergillus fumigatus. Having found that A. fumigatus-infected DCs do not express IFN-β, we evaluated ...
Tópico(s): Immunotherapy and Immune Responses
2010 - Wiley | Immunology
Valérie Gafa, Maria Elena Remoli, Elena Giacomini, Maria Cristina Gagliardi, Roberto Lande, Martina Severa, R. Grillot, Eliana M. Coccia,
Given the role played by chemokines in the selective homing of immune cells, we sought to characterize the profile of chemokines produced by human dendritic cells (DC) following in vitro Aspergillus fumigatus infection and their ability to recruit cells involved in the antifungal defense. At the onset of A. fumigatus infection, DC released elevated amounts of CXCL8 that promote the migration of polymorphonuclear cells (PMN). Moreover, soluble factors released from A. fumigatus-infected DC increased ...
Tópico(s): Fungal Infections and Studies
2007 - Elsevier BV | Microbes and Infection
Martina Severa, Fabiana Rizzo, Sundararajan Srinivasan, Marco Di Dario, Elena Giacomini, Maria Chiara Buscarinu, Melania Cruciani, Marilena P. Etna, Silvia Sandini, Rosella Mechelli, Antonella Farina, Pankaj Trivedi, Paul J. Hertzog, Marco Salvetti, Cinthia Farina, Eliana M. Coccia,
Alteration in endogenous Interferon (IFN) system may profoundly impact immune cell function in autoimmune diseases. Here, we provide evidence that dysregulation in IFN-regulated genes and pathways are involved in B cell- and monocyte-driven pathogenic contribution to Multiple Sclerosis (MS) development and maintenance. In particular, by using an Interferome-based cell type-specific approach, we characterized an increased susceptibility to an IFN-linked caspase-3 dependent apoptotic cell death in both ...
Tópico(s): Viral Infections and Immunology Research
2019 - Elsevier BV | Journal of Autoimmunity
Carlos Raymundo Martínez López, Bertha Ramos del Río, María Teresa Robles Rendón, Lucía Dolores Martínez González, Carlos Gonzalo Figueroa López,
El objetivo de este estudio fue determinar la correlacion entre la carga del cuidador y la dependencia percibida en una muestra de cuidadores informales de ninos con paralisis cerebral severa. Participo una muestra intencional de 88 menores del Centro de Rehabilitacion Infantil Teleton del Estado de Mexico. Se utilizo un diseno de tipo exploratorio, transversal, y correlacional. Los datos analizados corresponden a la Encuesta de Salud del Cuidador Primario Informal, la Entrevista de Carga del Cuidador ...
Tópico(s): Family and Disability Support Research
2012 - Universidad Veracruzana | Psicología y Salud