Emilio Matricciani, Liberato De,
... of literary works written by the Italian mystic Maria Valtorta to assess similarities and differences in her writings, ... indicates that the literary works explicitly attributable to Maria Valtorta differ significantly from her other literary works, which ... literature is very striking. A single author, namely Maria Valtorta, seems to be able to write texts so ...
Tópico(s): Topic Modeling
2018 - Multidisciplinary Digital Publishing Institute | Religions
Liberato De, Fernando La Greca, Emilio Matricciani,
... on the Vatican Hill. The recent studies on Maria Valtorta’s mystical writings have shown that they contain ... data not ascribable to her skills and awareness. Maria Valtorta describes also Peter’s first burial site, which, ... Rome. A mathematical estimate of the probability that Maria Valtorta, by chance, invented the data that lead to ...
Tópico(s): Archaeology and Historical Studies
2020 - Multidisciplinary Digital Publishing Institute | J — Multidisciplinary Scientific Journal
Emilio Matricciani, Liberato De,
... in The Gospel as revealed to me by Maria Valtorta to assess: (i) similarities and differences of the ... of the places and occasions for delivering them. Maria Valtorta wrote extraordinary speeches that she attributed to the ...
Tópico(s): Cognitive Science and Education Research
2020 - Multidisciplinary Digital Publishing Institute | J — Multidisciplinary Scientific Journal
Emilio Matricciani, Liberato De,
In The Gospel as revealed to me, Maria Valtorta reports a lot of information on the Holy Land at the time of Jesus: historical, archaeological, astronomical, geographical, meteorological. She states she has ...
Tópico(s): Biblical Studies and Interpretation
2017 - Multidisciplinary Digital Publishing Institute | Religions
Vanessa Zambelli, Giuseppe Di Grigoli, Margherita Scanziani, Silvia Valtorta, Maria Amigoni, Sara Belloli, Cristina Messa, Antonio Pesenti, Ferruccio Fazio, Giacomo Bellani, Rosa Maria Moresco,
This study investigates whether positron emission tomography (PET) can be used to monitor the inflammatory response and its correlation with the later fibroproliferative phase in an experimental model of acute lung injury.Hydrochloric acid (0.1 N, pH 1, 1.5 ml/kg) was instilled into the right bronchus of mice. A group of mice underwent a micro-computed tomography (CT) scan 1 h after lung injury and a series of 2-[(18)F]fluorine-2-deoxy-D: -glucose (FDG)-PET scans (6, 24 and 48 h and 7 days after surgery). ...
Tópico(s): Sepsis Diagnosis and Treatment
2012 - Springer Science+Business Media | Intensive Care Medicine
Fabio Benfenati, Flavia Valtorta, Maria Cecilia Rossi, Franco Onofri, Talvinder S. Sihra, Paul Greengard,
Synapsin I is a synaptic vesicle-specific phosphoprotein composed of a globular and hydrophobic head and of a proline-rich, elongated and basic tail. Synapsin I binds with high affinity to phospholipid and protein components of synaptic vesicles. The head region of the protein has a very high surface activity, strongly interacts with acidic phospholipids and penetrates the hydrophobic core of the vesicle membrane. In the present paper, we have investigated the possible functional effects of the ...
Tópico(s): Photoreceptor and optogenetics research
1993 - Rockefeller University Press | The Journal of Cell Biology
Flavia Valtorta, Maria Pennuto, Dario Bonanomi, Fabio Benfenati,
Abstract Synaptophysin (Syp) was the first synaptic vesicle (SV) protein to be cloned. Since its discovery in 1985, it has been used by us and by many laboratories around the world as an invaluable marker to study the distribution of synapses in the brain and to uncover the basic features of the life cycle of SVs. Although single gene ablation of Syp does not lead to an overt phenotype, a large body of experimental data both in vitro and in vivo indicate that Syp (alone or in association with homologous ...
Tópico(s): Neuroscience and Neuropharmacology Research
2004 - Wiley | BioEssays
Christopher E. Heise, Elham Taha, Luca Murru, Luisa Ponzoni, Angela Cattaneo, Fabrizia Claudia Guarnieri, Caterina Montani, Adele Mossa, Elena Vezzoli, Giulio Ippolito, Jonathan Zapata, Iliana Barrera, Alexey G. Ryazanov, James M. Cook, Michael M. Poe, Michael Rajesh Stephen, Maksym V. Kopanitsa, Roberta Benfante, Francesco Rusconi, Daniela Braida, Maura Francolini, Christopher G. Proud, Flavia Valtorta, Maria Passafaro, Mariaelvina Sala, Angela Bachi, Chiara Verpelli, Kobi Rosenblum, Carlo Sala,
Alterations in the balance of inhibitory and excitatory synaptic transmission have been implicated in the pathogenesis of neurological disorders such as epilepsy. Eukaryotic elongation factor 2 kinase (eEF2K) is a highly regulated, ubiquitous kinase involved in the control of protein translation. Here, we show that eEF2K activity negatively regulates GABAergic synaptic transmission. Indeed, loss of eEF2K increases GABAergic synaptic transmission by upregulating the presynaptic protein Synapsin 2b ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2016 - Oxford University Press | Cerebral Cortex
Danilo De Gregorio, Mirko Manchia, Bernardo Carpiniello, Flavia Valtorta, Maria Nobile, Gabriella Gobbi, Stefano Comai,
Antidepressants have a low rate of response paired with a delayed onset of action. Translational studies are thus seeking for novel targets for antidepressant drug development. Preclinical evidence has demonstrated that the endocannabinoid system plays an important role in mood and stress response, even if drugs targeting this system have not yet become available for clinical use. The dietary supplement N-Palmitoylethanolamide (PEA) is a fatty acid amide belonging to the endocannabinoid system with ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2018 - Elsevier BV | Journal of Affective Disorders
Alessandro Gabbiadini, Cristina Baldissarri, Federica Durante, Roberta Rosa Valtorta, Maria De Rosa, Marcello Gallucci,
The ongoing pandemic of COVID-19 has forced governments to impose a lockdown, and many people have suddenly found themselves having to reduce their social relations drastically. Given the exceptional nature of similar situations, only a few studies have investigated the negative psychological effects of forced social isolation and how they can be mitigated in a real context. In the present study, we investigated whether the amount of digital communication technology use for virtual meetings (i.e., ...
Tópico(s): Digital Mental Health Interventions
2020 - Frontiers Media | Frontiers in Psychology
Laura Guarnaccia, Giovanni Marfia, Matteo Maria Masseroli, Stefania Elena Navone, Melissa Balsamo, Manuela Caroli, Silvia Valtorta, Rosa Maria Moresco, Rolando Campanella, Emanuele Garzia, Laura Riboni, Marco Locatelli,
Glioblastoma is the most common primitive tumor in adult central nervous system (CNS), classified as grade IV according to WHO 2016 classification. Glioblastoma shows a poor prognosis with an average survival of approximately 15 months, representing an extreme therapeutic challenge. One of its distinctive and aggressive features is aberrant angiogenesis, which drives tumor neovascularization, representing a promising candidate for molecular target therapy. Although several pre-clinical studies and ...
Tópico(s): Cancer-related Molecular Pathways
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Angelo Corti, Anna Maria Gasparri, Michela Ghitti, Angelina Sacchi, Francesco Sudati, Martina Fiocchi, Valentina Buttiglione, Laura Perani, Alessandro Gori, Silvia Valtorta, Rosa Maria Moresco, Fabio Pastorino, Mirco Ponzoni, Giovanna Musco, Flavio Curnis,
NGR (asparagine-glycine-arginine) is a tumor vasculature-homing peptide motif widely used for the functionalization of drugs, nanomaterials and imaging compounds for cancer treatment and diagnosis. Unfortunately, this motif has a strong propensity to undergo rapid deamidation. This reaction, which converts NGR into isoDGR, is associated with receptor switching from CD13 to integrins, with potentially important manufacturing, pharmacological and toxicological implications. It is found that glycine ...
Tópico(s): Neuropeptides and Animal Physiology
2017 - Wiley | Advanced Functional Materials
Valentina Agnusdei, Sonia Minuzzo, Chiara Frasson, Angela Grassi, Fumiko Axelrod, Sanjeev Satyal, Austin Gurney, Timothy Hoey, Elena Seganfreddo, Giuseppe Basso, Silvia Valtorta, Rosa Maria Moresco, A. Amadori, Stefano Indraccolo,
Tópico(s): Acute Myeloid Leukemia Research
2013 - Springer Nature | Leukemia
Rosanna Mezzapelle, Eltjona Rrapaj, Elena Gatti, Chiara Ceriotti, Francesco De Marchis, Alessandro Preti, Antonello E. Spinelli, Laura Perani, Massimo Venturini, Silvia Valtorta, Rosa Maria Moresco, Lorenza Pecciarini, Claudio Doglioni, Michela Frenquelli, Luca Crippa, Camilla Recordati, Eugenio Scanziani, Hilda de Vries, Anton Berns, Roberta Frapolli, Renzo Boldorini, Maurizio D’Incalci, Marco E. Bianchi, Massimo P. Crippa,
Abstract Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2016 - Nature Portfolio | Scientific Reports
Sara Belloli, Michele Morari, Valentina Murtaj, Silvia Valtorta, Rosa Maria Moresco, Maria Carla Gilardi,
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the appearance of α-synuclein insoluble aggregates known as Lewy bodies. Neurodegeneration is accompanied by neuroinflammation mediated by cytokines and chemokines produced by the activated microglia. Several studies demonstrated that such an inflammatory process is an early event, and contributes to oxidative stress and mitochondrial dysfunctions. α-synuclein fibrillization ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2020 - Frontiers Media | Frontiers in Aging Neuroscience
... applied the theory to the literary corpus of Maria Valtorta, an Italian mystic of the XX-century. The ...
Tópico(s): Authorship Attribution and Profiling
2022 - Scientific Research Publishing | Open Journal of Statistics
Lorenzo Taiarol, Chiara Bigogno, Silvia Sesana, Marcelo Kravicz, Francesca Viale, E Pozzi, L Monza, Valentina Carozzi, C Meregalli, Silvia Valtorta, Rosa Maria Moresco, Marcus Koch, Federica Barbugian, Laura Russo, Giulio Dondio, Christian Steinkühler, Francesca Re,
Glioblastoma is the most common and aggressive brain tumor, associated with poor prognosis and survival, representing a challenging medical issue for neurooncologists. Dysregulation of histone-modifying enzymes (HDACs) is commonly identified in many tumors and has been linked to cancer proliferation, changes in metabolism, and drug resistance. These findings led to the development of HDAC inhibitors, which are limited by their narrow therapeutic index. In this work, we provide the proof of concept ...
Tópico(s): Peptidase Inhibition and Analysis
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Laura Guarnaccia, Stefania Elena Navone, Matteo Maria Masseroli, Melissa Balsamo, Manuela Caroli, Silvia Valtorta, Rosa Maria Moresco, Rolando Campanella, Luigi Schisano, Giorgio Fiore, Valentina Galiano, Emanuele Garzia, Giuseppe Ciniglio Appiani, Marco Locatelli, Laura Riboni, Giovanni Marfia,
Glioblastoma is the most aggressive primary brain malignancy in adults, with a poor prognosis of about 14 months. Recent evidence ascribed to metformin (MET), an antihyperglycemic drug, the potential to reduce cancer incidence and progression, but the molecular mechanisms underlying these effects need to be better investigated.Here, we tested the efficacy of MET on n = 10 primary glioblastoma endothelial cells (GECs), by viability and proliferation tests, as MTT and Live/Dead assays, apoptosis tests, ...
Tópico(s): Caveolin-1 and cellular processes
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Jacopo Maria Valtorta, Alessio Martino, Francesca Cuomo, Domenico Garlisi,
Internet of Things (IoT) devices are starting to play a predominant role in our everyday life. Application systems like Amazon Echo and Google Home allow IoT devices to answer human requests, or trigger some alarms and perform suitable actions. In this scenario, any data information, related device and human interaction are stored in databases and can be used for future analysis and improve the system functionality. Also, IoT information related to the network level (wireless or wired) may be stored ...
Tópico(s): Bluetooth and Wireless Communication Technologies
2019 - Springer Science+Business Media | Lecture notes in computer science
Maria Valtorta (1897-1961, Italian mystic)—bedridden since 1934 because paralyzed—wrote in Italian 13,193 pages of ... average value of fast handwriting speed, applicable to Maria Valtorta. She wrote for 1340 days, about 3.67 ...
Tópico(s): Mathematics, Computing, and Information Processing
2022 - Scientific Research Publishing | Open Journal of Statistics
Jenny Sassone, Giulia Maia Serratto, Flavia Valtorta, Vincenzo Silani, Maria Passafaro, Andrea Ciammola,
Loss of function mutations in the gene PARK2, which encodes the protein parkin, cause autosomal recessive juvenile parkinsonism, a neurodegenerative disease characterized by degeneration of the dopaminergic neurons localized in the substantia nigra pars compacta. No therapy is effective in slowing disease progression mostly because the pathogenesis of the disease is yet to be understood. From accruing evidence suggesting that the protein parkin directly regulates synapses it can be hypothesized ...
Tópico(s): Neurological disorders and treatments
2017 - Oxford University Press | Brain
Liberato De, Fernando La Greca, Emilio Matricciani,
The literary work of the mystical writer Maria Valtorta (1897-1961) contains a detailed life of Jesus, without any explicit dates with respect to the Julian calendar. She sets Jesus’ birth (Nativity) ...
Tópico(s): Literature, Language, and Rhetoric Studies
2023 - Scientific Research Publishing | Open Journal of Social Sciences
Roberta Rosa Valtorta, Maria Grazia Monaci,
Objectification is a form of dehumanization that implies the perception of others as mere objects. The present study aimed to expand research on objectification in the work domain by exploring the relationships between objectifying job features, self-objectification, and affective organizational commitment within a real work setting. Building on previous literature, we hypothesized that the execution of objectifying work activities would be positively related to workers' tendency to objectify themselves. ...
Tópico(s): Workaholism, burnout, and well-being
2023 - PsychOpen | Europe’s Journal of Psychology
V. Monafò, Mohamad Maghnie, Luigi Terracciano, A. Valtorta, Margherita Massa, Filiberto Maria Severi,
ABSTRACT. No further reports of associated X‐linked hypogammaglobulinemia and isolated growth hormone deficiency have appeared in the literature since the description of the first affected family, two brothers and two maternal uncles, by Fleisher et al. in 1980. We report here a 13‐year‐old boy with X‐linked agammaglobulinemia and isolated growth hormone deficiency, also probably inherited as an X‐linked trait. The height of an older agammaglobulinemic brother who died at 6 years of age was below ...
Tópico(s): Gastrointestinal disorders and treatments
1991 - Wiley | Acta Paediatrica
Alessia Lo Dico, Silvia Valtorta, Luisa Ottobrini, Rosa Maria Moresco,
Hypoxia is a key driver of tumor adaptation promoting tumor progression and resistance to therapy. Hypoxia related pathways might represent attractive targets for the treatment of Glioblastoma Multiforme (GBM), that up to date is characterized by a poor prognosis. Primary aim of this study was to investigate the role of hypoxia and hypoxia-related modifications in the effect of temozolomide (TMZ) given alone or in association with the antidiabetic agent Metformin (MET) or the PI3K/mTOR blocker, BEZ235. ...
Tópico(s): Mitochondrial Function and Pathology
2019 - Frontiers Media | Frontiers in Oncology
Serena Redaelli, Donatella Conconi, Elena Sala, Nicoletta Villa, Francesca Crosti, Gaia Roversi, Ilaria Catusi, Chiara Valtorta, Maria Paola Recalcati, Leda Dalprà, Marialuisa Lavitrano, Angela Bentivegna,
Improvements in microarray-based comparative genomic hybridization technology have allowed for high-resolution detection of genome wide copy number alterations, leading to a better definition of rearrangements and supporting the study of pathogenesis mechanisms. In this study, we focused our attention on chromosome 8p. We report 12 cases of 8p rearrangements, analyzed by molecular karyotype, evidencing a continuum of fragility that involves the entire short arm. The breakpoints seem more concentrated ...
Tópico(s): Congenital Ear and Nasal Anomalies
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Mauro Bozzola, Luciano Tatò, M. Cisternino, C Nava, A. Valtorta, Maria Chiesa, Filiberto Maria Severi, D Gaburro,
Tópico(s): Growth Hormone and Insulin-like Growth Factors
1986 - Springer Science+Business Media | Journal of Endocrinological Investigation
Chiara Leoni, Andrea Menegon, Fabio Benfenati, Daniela Toniolo, Maria Pennuto, Flavia Valtorta,
We have investigated the process leading to differentiation of PC12 cells. This process is known to include extension of neurites and changes in the expression of subsets of proteins involved in cytoskeletal rearrangements or in neurosecretion. To this aim, we have studied a PC12 clone (trk-PC12) stably transfected with the nerve growth factor receptor TrkA. These cells are able to undergo both spontaneous and neurotrophin-induced morphological differentiation. However, both undifferentiated and ...
Tópico(s): Nerve injury and regeneration
1999 - American Society for Cell Biology | Molecular Biology of the Cell
Michela Rigoni, Giampietro Schiavo, Anne Weston, Paola Caccin, Federica Allegrini, Maria Pennuto, Flavia Valtorta, Cesare Montecucco, Ornella Rossetto,
The mechanisms of action of four snake presynaptic phospholipase A2 neurotoxins were investigated in cultured neurons isolated from various parts of the rat brain. Strikingly, physiological concentrations of notexin, β-bungarotoxin, taipoxin or textilotoxin induced a dose-dependent formation of discrete bulges at various sites of neuronal projections. Neuronal bulging was paralleled by the redistribution of the two synaptic vesicle markers synaptophysin I (SypI) and vesicle-attached membrane protein ...
Tópico(s): Ion channel regulation and function
2004 - The Company of Biologists | Journal of Cell Science
Mauro Bozzola, M. Cisternino, I. Biscaldi, Mohamad Maghnie, A. Valtorta, Antonia Moretta, Filiberto Maria Severi,
Tópico(s): Genetics and Neurodevelopmental Disorders
1988 - Springer Science+Business Media | European Journal of Pediatrics