Produção Nacional
Revisado por pares
Maria Da Glória S. Carvalho, Maria Da Conceição E. Vianni, John A. Elliott, Michael Reeves, Richard R. Facklam, Lúcia Martins Teixeira,
Information on the role of some bacterial species, such as Lactococcus garvieae and Enterococcus gallinarum, in animal as well as human infections remains scarce. Difficulties in the precise laboratory identification and possible misidentification as other better known related microorganism can, at least in part, account for the limitation of the data available6.
Tópico(s): Probiotics and Fermented Foods
1997 - Springer Nature | Advances in experimental medicine and biology
José Francisco Carvalho, María da Gloria Carvalho, William C. Merrick,
Previous studies have indicated that the high-molecular-weight form of elongation factor 1 (EF-1H) contained four subunits (alpha, beta, gamma, and delta). Using the conventional methods of gel-filtration and ion-exchange chromatography, various forms of elongation factor 1 (EF-1 alpha, EF-1 beta delta, EF-1 beta gamma delta) have been purified from rabbit reticulocyte lysate. The procedure described allows one to purify these factors from a single batch of lysate in sufficient amounts for physical ...
Tópico(s): Biochemical Analysis and Sensing Techniques
1984 - Elsevier BV | Archives of Biochemistry and Biophysics
Produção Nacional
Revisado por pares
Maria-Cristina de C. Brandileone, Rosemeire Cobo Zanella, Samanta Cristine Grassi Almeida, Angela Pires Brandão, Ana Freitas Ribeiro, Telma-Regina M.P. Carvalhanas, Helena Sato, Ana Lúcia Andrade, Jennifer R. Verani, Maria-Luiza L. S. Guerra, Lincoln S. do Prado, Sérgio Bokermann, Ana-Paula S. Lemos, Maria-Cecília O. Gorla, Bernadete L. Liphaus, Gabriela Policena, María da Gloria Carvalho, Ana Paula Sayuri Sato, Maria-Lígia Nerger, Mônica Tilli Reis Pessôa Conde,
In March 2010, Brazil introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in the routine infant immunization program using a 4-dose schedule and catch-up for children <23 months. We investigated PCV10 effect on nasopharyngeal carriage with vaccine-type Streptococcus pneumoniae (Spn) and non-typeable Haemophilus influenzae (NTHi) among children in São Paulo city. Cross-sectional surveys were conducted in 2010 (baseline) and 2013 (post-PCV10). Healthy PCV-naïve children aged 12–23 months were ...
Tópico(s): Respiratory viral infections research
2016 - Elsevier BV | Vaccine
Produção Nacional
Revisado por pares
Juliana de Saldanha da Gama Fischer, Lujian Liao, Paulo C. Carvalho, Valmir C. Barbosa, Gilberto B. Domont, María da Gloria Carvalho, John R. Yates,
Perillyl alcohol (POH) is a naturally occurring terpene and a promising chemotherapeutic agent for glioblastoma multiform; yet, little is known about its molecular effects. Here we present results of a semi-quantitative proteomic analysis of A172 cells exposed to POH for different time-periods (1′, 10′, 30′, 60′, 4 h, and 24 h). The analysis identified more than 4000 proteins; which were clustered using PatternLab for proteomics and then linked to Ras signaling, tissue homeostasis, induction of apoptosis, ...
Tópico(s): Microbial Natural Products and Biosynthesis
2010 - Elsevier BV | Journal of Proteomics
Produção Nacional
Revisado por pares
Paulo C. Carvalho, Xuemei Han, Tao Xu, Daniel Cociorva, María da Gloria Carvalho, Valmir C. Barbosa, John R. Yates,
Abstract Summary: XDIA is a computational strategy for analyzing multiplexed spectra acquired using electron transfer dissociation and collision-activated dissociation; it significantly increases identified spectra (∼250%) and unique peptides (∼30%) when compared with the data-dependent ETCaD analysis on middle-down, single-phase shotgun proteomic analysis. Increasing identified spectra and peptides improves quantitation statistics confidence and protein coverage, respectively. Availability: The software ...
Tópico(s): Anomaly Detection Techniques and Applications
2010 - Oxford University Press | Bioinformatics
Produção Nacional
Revisado por pares
Milena Soares dos Santos, J. Fraga De Azevedó, Ana Paula de O. Menezes, Soraia Machado Cordeiro, Eliane Cunegundes Escobar, Josilene Borges Torres Lima, Leila Carvalho Campos, Maria da Glória S. Carvalho, Mitermayer Galvão dos Reis, Albert I. Ko, Joice Neves Reis,
Hospital-based surveillance for pneumococcal meningitis has been conducted since January 1996 in the city of Salvador, Brazil. The purpose of this study was to describe the temporal evolution of Penicillin Non-Susceptible Streptococcus pneumoniae (PNSSP) in regards to serotype distributions and clonal diversity recovered from meningitis cases over 17 years. Broth microdilution was used to identify pneumococcal isolates that were PNSSP (Minimum Inhibitory Concentration > 0.12 μg/ml). The annual incidence ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2015 - BioMed Central | BMC Infectious Diseases
Produção Nacional
Revisado por pares
Leila Carvalho Campos, Maria da Glória S. Carvalho, Bernard Beall, Soraia Machado Cordeiro, Daniele Takahashi, Mitermayer Galvão dos Reis, Albert I. Ko, Joice Neves Reis,
The newly described Streptococcus pneumoniae serotype 6C accounted for 2.3% (16/709) of meningitis cases and 3.2% (3/95) of nasopharyngeal isolates from healthy individuals in Brazil. The strains were multidrug resistant (18.8%) and genetically diverse. Despite low serotype 6C prevalence, continuous surveillance is necessary to guide vaccine strategies.
Tópico(s): Respiratory viral infections research
2009 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Produção Nacional
Revisado por pares
Juliana de Saldanha da Gama Fischer, Paulo C. Carvalho, Clóvis Orlando da Fonseca, Lujian Liao, Wim Degrave, María da Gloria Carvalho, John R. Yates, Gilberto B. Domont,
Glioblastoma multiform (GBM) is by far the most malignant glioma. We have introduced a new treatment for GBMs that comprises the inhalation of a naturally occurring terpene with chemotherapeutic properties known as perillyl alcohol (POH). Clinical trial results on recurrent GBM patients showed that POH extends the average life by more than eight months, temporarily slows tumor growth, and in some cases even decreases tumor size. After approximately seven months, the tumor continues to grow and leads ...
Tópico(s): Biotin and Related Studies
2010 - American Chemical Society | Journal of Proteome Research
Produção Nacional
Revisado por pares
Paulo C. Carvalho, Juliana S. G. Fischer, Emily I. Chen, Gilberto B. Domont, María da Gloria Carvalho, Wim Degrave, John R. Yates, Valmir C. Barbosa,
Abstract Background Spectral counting is a shotgun proteomics approach comprising the identification and relative quantitation of thousands of proteins in complex mixtures. However, this strategy generates bewildering amounts of data whose biological interpretation is a challenge. Results Here we present a new algorithm, termed GO Explorer (GOEx), that leverages the gene ontology (GO) to aid in the interpretation of proteomic data. GOEx stands out because it combines data from protein fold changes ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2009 - BioMed Central | Proteome Science
Produção Nacional
Revisado por pares
Lúcia Martins Teixeira, Maria Da Glória S. Carvalho, Vânia Lúcia Carreira Merquior, Arnold G. Steigerwalt, Maria da Glória Martins Teixeira, D J Brenner, Richard R. Facklam,
Tópico(s): Genomics and Phylogenetic Studies
1997 - Springer Nature | Advances in experimental medicine and biology
Produção Nacional
Revisado por pares
Marcelo Soares da Mota e Silva, María da Gloria Carvalho, Josino Costa Moreira, Emiliano Barreto, Karol Fireman de Farias, Cristiane Araújo Nascimento, Francisca Maria Nunes da Silva, Tiago Gomes de Andrade, Ronir Raggio Luiz, Rodrigo S. Moura‐Neto, Fernanda Lattario Ribeiro,
Green Tobacco Sickness (GTS) is an occupational illness caused by dermal absorption of nicotine from tobacco leaves. It affects thousands of farm workers worldwide. Brazil is the second tobacco producer in the world; despite this, there are few studies on GTS among Brazilian harvesters. This study aimed to determine the prevalence of GTS among a population of tobacco workers from a producing area in northeastern Brazil and investigate whether the occurrence of the disease was influenced by factors ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2018 - BioMed Central | BMC Research Notes
Produção Nacional
Revisado por pares
Ana Paula de O. Menezes, J. Fraga De Azevedó, Mariela C. Leite, Leila Carvalho Campos, Marcelo Cunha, Maria da Glória S. Carvalho, Mitermayer Galvão dos Reis, Albert I. Ko, Daniel M. Weinberger, Guilherme S. Ribeiro, Joice Neves Reis,
Information on pneumococcal carriage in the pre-vaccine period is essential to predict and assess the impact of PCV in settings where disease surveillance is particularly difficult. Therefore, we present data on pneumococcal carriage before the introduction of the 10-valent-pneumococcal conjugate vaccine (PCV10) in Brazil. We conducted a prospective study on a cohort of 203 children aged <5 years old, randomly selected in an urban community located in the periphery of the city of Salvador, Brazil ...
Tópico(s): Bacterial Infections and Vaccines
2015 - Elsevier BV | Vaccine
Fabiana Cristina Pimenta, Benild Moiane, Robert E. Gertz, Sopio Chochua, Paula M. Snippes Vagnone, Ruth Lynfield, Betuel Sigaúque, María da Gloria Carvalho, Bernard Beall,
The pneumococcal serogroup 15 comprises four capsular polysaccharide serotypes (15A, 15B, 15C, 15F) that collectively account for an impactful disease burden (1, 2). These four serotypes are defined by Quellung reaction typing, employing specific serologic factor sera to visualize the capsule (3) (Table 1). Each of these four serotypes shares an identical pentasaccharide repeat unit that forms an identical linear structure in types 15A and 15F, and a distinct branched structure in types 15B and 15C ( ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2021 - American Society for Microbiology | Journal of Clinical Microbiology
Osatohamwen I. Idubor, Miwako Kobayashi, Linus Ndegwa, Mary Okeyo, Tura Galgalo, Rosalia Kalani, Susan Githii, Elizabeth Hunsperger, Arunmozhi Balajee, Jennifer R. Verani, María da Gloria Carvalho, Jonas M. Winchell, Chris Van Beneden, Marc‐Alain Widdowson, Lyndah Makayotto, Sandra S. Chaves,
Piloted in Kenya, the Detection and Response to Respiratory Events (DaRRE) strategy could serve as a model for other countries in the region to build capacity for prevention, detection, and response to respiratory disease outbreaks.
Tópico(s): Influenza Virus Research Studies
2020 - Centers for Disease Control and Prevention | MMWR Morbidity and Mortality Weekly Report
Fabiana Cristina Pimenta, Robert E. Gertz, Sohee Park, Ellie Kim, Iaci Moura, Jennifer Milucky, Nadine Rouphael, Monica M. Farley, Lee H. Harrison, Nancy M. Bennett, Godfrey Bigogo, Daniel R. Feikin, Robert F. Breiman, Fernanda C. Lessa, Cynthia G. Whitney, Gowrisankar Rajam, Jarad Schiffer, María da Gloria Carvalho, Bernard Beall,
.Streptococcus pneumoniae is a highly impactful bacterial pathogen on a global scale. The principal pneumococcal virulence factor and target of effective vaccines is its polysaccharide capsule, of which there are many structurally distinct forms. Here we describe four distinct strains of three Mitis group commensal species (Streptococcus infantis, Streptococcus mitis, and Streptococcus oralis) recovered from upper respiratory tract specimens from adults in Kenya and the United States that were PCR- ...
Tópico(s): Respiratory viral infections research
2019 - Frontiers Media | Frontiers in Microbiology
Fernanda C. Lessa, Jennifer Milucky, Nadine Rouphael, Nancy M. Bennett, H. Keipp Talbot, Lee H. Harrison, Monica M. Farley, Jeremy Walston, Fabiana Cristina Pimenta, Robert E. Gertz, Gowrisankar Rajam, María da Gloria Carvalho, Bernard Beall, Cynthia G. Whitney,
Streptococcus pneumoniae's polysaccharide capsule is an important virulence factor; vaccine-induced immunity to specific capsular polysaccharide effectively prevents disease. Serotype 1 S. pneumoniae is rarely found in healthy persons, but is highly invasive and a common cause of meningitis outbreaks and invasive disease outside of the United States. Here we show that genes for polysaccharide capsule similar to those expressed by pneumococci were commonly detected by polymerase chain reaction among ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2018 - Nature Portfolio | Scientific Reports
Tolulope Adebanjo, Fernanda C. Lessa, Hélio Mucavele, Benild Moiane, Alberto Chaúque, Fabiana Cristina Pimenta, Sérgio Massora, María da Gloria Carvalho, Cynthia G. Whitney, Betuel Sigaúque,
Background Pneumococcal colonization is a precursor to pneumonia, and pneumococcal conjugate vaccines (PCV) can decrease vaccine-type (VT) colonization. Pneumococcal colonization studies are traditionally done among healthy children in the community; however, VT colonization prevalence may differ between these children and those with pneumonia. We assessed overall and VT pneumococcal colonization and factors associated with colonization among children with and without pneumonia after Mozambique introduced ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2018 - Public Library of Science | PLoS ONE
Jennifer R. Verani, Sérgio Massora, Sozinho Acácio, R. Santos, Delfino Vubil, Fabiana Cristina Pimenta, Iaci Moura, Cynthia G. Whitney, Maria Helena Costa, Eusébio Macete, Maria Benigna Matsinhe, María da Gloria Carvalho, Betuel Sigaúque,
Nasopharyngeal carriage is a precursor for pneumococcal disease and can be useful for evaluating pneumococcal conjugate vaccine (PCV) impact. We studied pre-PCV pneumococcal carriage among HIV-infected and -uninfected children in Mozambique. Between October 2012 and March 2013, we enrolled HIV-infected children age <5 years presenting for routine care at seven HIV clinics in 3 sites, including Maputo (urban-south), Nampula (urban-north), and Manhiça (rural-south). We also enrolled a random sample of HIV- ...
Tópico(s): Respiratory viral infections research
2018 - Public Library of Science | PLoS ONE
Betuel Sigaúque, Benild Moiane, Sérgio Massora, Fabiana Cristina Pimenta, Jennifer R. Verani, Hélio Mucavele, Alberto Chaúque, Llorenç Quintó, R. Santos, María da Gloria Carvalho, Cynthia G. Whitney, Fernanda C. Lessa,
Background: Pneumococcal carriage is a precursor of invasive pneumococcal disease. Mozambique introduced 10-valent pneumococcal conjugate vaccine (PCV10) in April 2013, using a 3-dose schedule without a booster. We evaluated PCV10 impact on pneumococcal carriage and colonization density by HIV status. Methods: We conducted 2 cross-sectional surveys (pre and post PCV10 introduction) among children 6 weeks to 59 months old. Participants included HIV-infected children presenting for routine care at outpatient ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2018 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Betuel Sigaúque, Miwako Kobayashi, Delfino Vubil, Ariel Nhacolo, Alberto Chaúque, Benild Moaine, Sérgio Massora, Inácio Mandomando, Tacilta Nhampossa, Quique Bassat, Fabiana Cristina Pimenta, Clara Menéndez, María da Gloria Carvalho, Eusébio Macete, Stephanie J. Schrag,
Background Maternal group B streptococcal (GBS) vaccines under development hold promise to prevent GBS disease in young infants. Sub-Saharan Africa has the highest estimated disease burden, although data on incidence and circulating strains are limited. We described invasive bacterial disease (IBD) trends among infants <90 days in rural Mozambique during 2001–2015, with a focus on GBS epidemiology and strain characteristics. Methods Community-level birth and mortality data were obtained from Manhiça' ...
Tópico(s): Pneumonia and Respiratory Infections
2018 - Public Library of Science | PLoS ONE
Miwako Kobayashi, Laura Conklin, Godfrey Bigogo, Geofrey Jagero, Lee M. Hampton, Katherine E. Fleming-Dutra, Muthoni Junghae, María da Gloria Carvalho, Fabiana Cristina Pimenta, Bernard Beall, Thomas H. Taylor, Kayla F. Laserson, John Vulule, Chris Van Beneden, Lindsay Kim, Daniel R. Feikin, Cynthia G. Whitney, Robert F. Breiman,
Pneumococci are spread by persons with nasopharyngeal colonization, a necessary precursor to invasive disease. Pneumococcal conjugate vaccines can prevent colonization with vaccine serotype strains. In 2011, Kenya became one of the first African countries to introduce the 10-valent pneumococcal conjugate vaccine (PCV10) into its national immunization program. Serial cross-sectional colonization surveys were conducted to assess baseline pneumococcal colonization, antibiotic resistance patterns, and ...
Tópico(s): Respiratory viral infections research
2017 - BioMed Central | BMC Infectious Diseases
Laura Conklin, Godfrey Bigogo, Geofrey Jagero, Lee M. Hampton, Muthoni Junghae, María da Gloria Carvalho, Fabiana Cristina Pimenta, Bernard Beall, Thomas H. Taylor, Brian D. Plikaytis, Kayla F. Laserson, John Vulule, Chris Van Beneden, Cynthia G. Whitney, Robert F. Breiman, Daniel R. Feikin,
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis and sepsis in developing countries, particularly among children and HIV-infected persons. Pneumococcal oropharyngeal (OP) or nasopharyngeal (NP) colonization is a precursor to development of invasive disease. New conjugate vaccines hold promise for reducing colonization and disease. Prior to introduction of 10-valent pneumococcal conjugate vaccine (PCV10), we conducted a cross-sectional survey among HIV-infected parents of children ...
Tópico(s): Respiratory viral infections research
2015 - BioMed Central | BMC Infectious Diseases
Produção Nacional
Revisado por pares
Thaís Messias McCormick, Nathalie HS Canedo, Yara Furtado, Filomena Aste Silveira, Roberto Lima, Andréa DF Rosman, Gutemberg L Almeida Filho, María da Gloria Carvalho,
Human papillomavirus (HPV) inactivates the retinoblastoma 1 (RB1) gene by promoter methylation and reduces cellular E-cadherin expression by overexpression of DNA methyltransferase 1 (DNMT1). The Epstein-Barr virus (EBV) is an oncogenic virus that may be related to cervical carcinogenesis. In gastric cancer, it has been demonstrated that E-cadherin gene (CDH1) hypermethylation is associated with DNMT1 overexpression by EBV infection. Our aim was to analyze the gene promoter methylation frequency of RB1 ...
Tópico(s): Viral-associated cancers and disorders
2015 - BioMed Central | Diagnostic Pathology
Produção Nacional
Revisado por pares
Ana Lúcia Andrade, Yves Mauro Fernandes Ternes, María Aparecida Vieira, Weslley Garcia Moreira, Juliana Lamaro‐Cardoso, André Kipnis, Maria Regina Alves Cardoso, Maria Cristina C. Brandileone, Iaci Moura, Fabiana Cristina Pimenta, María da Gloria Carvalho, Fabrícia Oliveira Saraiva, Cristiana M. Toscano, Ruth Minamisava,
Background 10-valent conjugate pneumococcal vaccine/PCV10 was introduced in the Brazilian National Immunization Program along the year of 2010. We assessed the direct effectiveness of PCV10 vaccination in preventing nasopharyngeal/NP pneumococcal carriage in infants. Methods A cross-sectional population-based household survey was conducted in Goiania Brazil, from December/2010-February/2011 targeting children aged 7–11 m and 15–18 m. Participants were selected using a systematic sampling. NP swabs, ...
Tópico(s): Bacterial Infections and Vaccines
2014 - Public Library of Science | PLoS ONE
María da Gloria Carvalho, Fabiana Cristina Pimenta, Iaci Moura, Alexis Roundtree, Robert E. Gertz, Zhongya Li, Geofrey Jagero, Godfrey Bigogo, Muthoni Junghae, Laura Conklin, Daniel R. Feikin, Robert F. Breiman, Cynthia G. Whitney, Bernard Beall,
We performed culture-based and PCR-based tests for pneumococcal identification and serotyping from carriage specimens collected in rural and urban Kenya. Nasopharyngeal specimens from 237 healthy children 98.7%) with the reference cmPCR amplicon for the st, while cmPCR amplicons from lytA-negative specimens were generally more divergent. Separate testing of 56 A-OPs and 56 A-NPs revealed that ∼94% of the positive cmPCR results from A-NP/OPs were from OP microbiota. In contrast, A-NPs yielded >2- ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2013 - PeerJ, Inc. | PeerJ
Fabiana Cristina Pimenta, Alexis Roundtree, Ahmet Soysal, Mustafa Bakır, Mignon du Plessis, Nicole Wolter, Anne von Gottberg, Lesley McGee, María da Gloria Carvalho, Bernard Beall,
We developed and validated a real-time PCR assay consisting of 7 triplexed reactions to identify 11 individual serotypes plus 10 small serogroups representing the majority of disease-causing isolates of Streptococcus pneumoniae. This assay targets the 13 serotypes included within the 13-valent conjugate vaccine and 8 additional key serotypes or serogroups. Advantages over other serotyping assays are described. The assay will be expanded to 40 serotypes/serogroups. We will provide periodic updates ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2012 - American Society for Microbiology | Journal of Clinical Microbiology
María da Gloria Carvalho, Godfrey Bigogo, Muthoni Junghae, Fabiana Cristina Pimenta, Iaci Moura, Alexis Roundtree, Zhongya Li, Laura Conklin, Daniel R. Feikin, Robert F. Breiman, Cynthia G. Whitney, Bernard Beall,
Monitoring pneumococcal carriage serotype distributions is increasingly used to study pneumococcal biology, disease epidemiology, and vaccine impact. Potentially complicating DNA-based carriage assessment is the well-documented history of genetic recombination between pneumococci and related species
Tópico(s): Pneumonia and Respiratory Infections
2012 - American Society for Microbiology | Journal of Clinical Microbiology
Produção Nacional
Revisado por pares
Renata F. Fonseca, Márcia Tie Kawamura, José Antônio de Oliveira, Anselmo Teixeira, Gilda Alves, María da Gloria Carvalho,
Members of the Herpesviridae family have been implicated in a number of tumours in humans. At least 75% of the human population has had contact with cytomegalovirus (HCMV). In this work, we screened 75 Brazilian glioma biopsies for the presence of HCMV DNA sequences. HCMV DNA was detected in 36% (27/75) of the biopsies. It is possible that HCMV could be a co-factor in the evolution of brain tumours.
Tópico(s): Toxoplasma gondii Research Studies
2012 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Dolly Sharma, Wendy Baughman, Amy Holst, Stephanie Thomas, Delois Jackson, María da Gloria Carvalho, Bernard Beall, Sarah W. Satola, Robert Jerris, Shabnam Jain, Monica M. Farley, J. Pekka Nuorti,
Nasopharyngeal (NP) carriage and invasive pneumococcal disease (IPD) attributable to serotypes in the 7-valent pneumococcal conjugate vaccine (PCV7) declined dramatically after vaccine introduction, whereas non-PCV7 serotypes increased modestly. Characteristics of pneumococcal carriage and IPD among children in Atlanta, GA, were compared during 2 time periods: before PCV7 introduction and before 13-valent PCV (PCV13) introduction.NP swabs from 231 and 451 children 6-59 months old receiving outpatient ...
Tópico(s): Bacterial Infections and Vaccines
2012 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Produção Nacional
Revisado por pares
David Esquenazi, Ivo Bussoloti Filho, María da Gloria Carvalho, Fernando Souza de Barros,
The human papillomavirus (HPV) is a DNA virus, which belongs to papillomaviridae family, being of low and high risk, which infect the skin and mucous membranes and can induce benign and malign tumor formation. In the oral mucosa they have been associated with oral papilloma, focal epithelial hyperplasia, leucoplakia and oral neoplasia.to study the frequency of HPV finding in oral mucosa of normal people.Prospective study, cross-sectional cohort. One hundred volunteers, young adults, healthy, aged ...
Tópico(s): Oral Health Pathology and Treatment
2010 - Elsevier BV | Brazilian Journal of Otorhinolaryngology