Produção Nacional
Revisado por pares
Cynthia Meira de Almeida Godoy, Luana Celi Silva Aprígio, Eudes Paiva de Godoy, Mariana Câmara Martins Bezerra Furtado, Daniel Coelho, Lourdes Bernadete Rocha de Souza, Antònio Manuel Goveial de Oliveira,
Tópico(s): Body Contouring and Surgery
2018 - Springer Science+Business Media | Obesity Surgery
Produção Nacional
Revisado por pares
Patrícia F. Laranjeiro, Daniel Merchán, Leonardo A. Godoy, Mariana Giannotti, Hugo Tsugunobu Yoshida Yoshizaki, Matthias Winkenbach, Cláudio Barbieri da Cunha,
Large-scale urban sensing data, such as vehicle global positioning system (GPS) traces, are emerging as an important data source for urban planning. However, the widespread availability of commercial truck GPS data comes with a large diversity of sources with different operational characteristics. In this context, motivated by addressing ongoing challenges in urban logistics from the perspective of transport geography, we describe an approach to exploring and analyzing a large amount of vehicle GPS ...
Tópico(s): Urban Transport and Accessibility
2019 - Elsevier BV | Journal of Transport Geography
Produção Nacional
Revisado por pares
Guilherme Tavares de Arruda, Patrícia Driusso, Jéssica Cordeiro Rodrigues, Amanda Garcia de Godoy, Mariana Arias Ávila,
Objective: To evaluate the numerical rating scale (NRS) measurement properties in women with dysmenorrhea. Methods: This was an online clinimetric study. Brazilian women aged over 18 years old with internet access to respond to online instruments were included in the study. We evaluated criterion validity (comparing women with and without dysmenorrhea), construct validity between the NRS and the bodily pain domain of the SF-36, test-retest reliability, and measurement errors (in women with dysmenorrhea). ...
Tópico(s): Complementary and Alternative Medicine Studies
2022 - Informa | Gynecological Endocrinology
Produção Nacional
Revisado por pares
José Maria Pereira de Godoy, Gleison Juliano da Silva Russeff, Carolina Hungaro Cunha, Debora Yuri Sato, Desirée Franccini Del Frari Silva, Henrique José Pereira de Godoy, Mariana Orate Menezes da Silva, Henrique Amorim, Marina Morães Lopes Soares, Maria de Fátima Guerreiro Godoy,
Among the multiple complex pathophysiological mechanisms underlying Covid-19 pneumonia, immunothrombosis has been shown to play a key role.The aim of the present study was to assess the monthly prevalence of deep venous thrombosis in a university hospital that admitted 5159 patients with Covid-19 in the medical ward and intensive care unit (ICU) and investigate whether there has been an increase in the prevalence of deep vein thrombosis and dead recently.A clinical trial was conducted evaluating ...
Tópico(s): Long-Term Effects of COVID-19
2021 - SAGE Publishing | Phlebology The Journal of Venous Disease
Produção Nacional
Revisado por pares
Carmen Regina Leal de Assumpção, Tatiana M.C. Brunini, Natália Rodrigues Pereira, Amélio F. Godoy‐Matos, Mariana A.S. Siqueira, Giovanni E. Mann, Antônio Claúdio Mendes‐Ribeiro,
Nitric oxide (NO) is a short-lived gaseous messenger with multiple physiological functions including regulation of blood flow, platelet adhesion and aggregation inhibition. NO synthases (NOS) catalyze the conversion of cationic amino acid l-arginine in l-citrulline and NO. Despite an increasing prevalence of obesity and metabolic syndrome (MetS) in the last decades, the exact mechanisms involved in the pathogenesis and cardiovascular complications are not fully understood. We have examined the effects ...
Tópico(s): Diabetes Treatment and Management
2010 - Elsevier BV | Blood Cells Molecules and Diseases
Produção Nacional
Revisado por pares
Eddie Fernando Cândido Murta, Hélio Godoy Franca, Mariana Corrêa Carneiro, Mário Sérgio Silva Gomes Caetano, Sheila Jorge Adad, Maria Azniv Hazarabedian de Souza,
Objetivo: analisar a paridade e o início da atividade sexual de mulheres com câncer de colo uterino invasivo. Métodos: foram estudados retrospectivamente 362 casos de câncer de colo uterino tratados no Ambulatório de Oncologia Ginecológica da Faculdade de Medicina do Triângulo Mineiro de 1978 a 1995. Foram analisadas a idade do início da atividade sexual e a paridade, em períodos, de acordo com a data do diagnóstico, de 1978 a 1983 (65 casos), de 1984 a 1989 (127 casos) e de 1990 a 1995 (170 casos). ...
Tópico(s): Women's cancer prevention and management
1999 - Thieme Medical Publishers (Germany) | Revista Brasileira Ginecologia e Obstetrícia
María Roqué, Clara Pott Godoy, Mariana Castellanos, Eduardo Pusiol, Luis S. Mayorga,
Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population. The disease can be caused by one of the more than 900 different mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. However, the deletion of the phe508-codon is the most prevalent mutation observed. Our aim was to perform a screening for this mutation (ΔF508, or F508del) in the population of Mendoza, Argentina. For the screening, 1,000 blood samples were obtained from CF asymptomatic ...
Tópico(s): Congenital Ear and Nasal Anomalies
2001 - Wiley | Human Mutation
Produção Nacional
Revisado por pares
Margarete Ribeiro-Dasilva, Sérgio Roberto Peres Line, Maria Cristina Leme Godoy dos Santos, Mariana Trevisani Arthuri, Wei Hou, Roger B. Fillingim, Célia Marisa Rizzatti‐Barbosa,
Temporomandibular joint disorders (TMJD) affect women with greater frequency than men, and sex hormones may contribute to this female predominance. Therefore, this study investigated whether estrogen receptor-alpha (XbaI/PvuII) single nucleotide polymorphisms (SNPs) are associated with TMJD in women. DNA was obtained from 200 women with TMJD (100 with chronic pain and 100 with signs of TMJD but no pain) diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD) and ...
Tópico(s): Osteoarthritis Treatment and Mechanisms
2009 - Elsevier BV | Journal of Pain
Produção Nacional
Revisado por pares
Lúcio Souza Gonçalves, Dennis de Carvalho Ferreira, Nicholas C. K. Heng, Fábio Vidal, Henrique Fragoso dos Santos, Diogo Godoy Zanicotti, Mariana M. Vasconcellos, Mayra Stambovsky, Blair Lawley, Norma de Paula Motta Rubini, Kátia Regina Netto dos Santos, G. J. Seymour,
This study compared the oral bacteriome between HIV-1-infected and non-HIV-1-infected Brazilian children/teenagers.Whole saliva, biofilm from the dorsal surface of the tongue and biofilm from supragingival and subgingival sites were collected from 27 HIV-1-infected and 30 non-HIV-1-infected individuals. Bacterial genomic DNA was extracted and 16S rRNA genes were sequenced using next-generation sequencing technology (Ion Torrent).In the supragingival biofilm, the phylum Firmicutes and genus Streptococcus ...
Tópico(s): Oral and gingival health research
2019 - Wiley | Journal Of Clinical Periodontology
Produção Nacional
Revisado por pares
Maria Luísa Buffo de Cápua, Flávia Eiras Dela Coleta, Ana Paula Massae Nakage Canesin, Aline Vieira Godoy, Sabryna Gouveia Calazans, Mariana Rodrigues Miotto, Carlos Roberto Daleck, Áureo Evangelista Santana,
O linfoma é uma neoplasia de elevada incidência na população canina mundial, e que apresenta sinais clínicos diversos, dependentes da classificação anatômica e da extensão da doença. Este estudo objetivou avaliar as características clínicas e hematológicas de cães com linfoma no momento do diagnóstico, além da evolução clínica dos mesmos ao longo do tratamento com o protocolo de Madison-Wisconsin. Dos 18 cães inseridos no estudo, 50% apresentaram a forma multicêntrica da doença e 33% a forma cutânea. ...
Tópico(s): Infectious Diseases and Mycology
2011 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural
Produção Nacional
Revisado por pares
Jessika Cadavid Sierra, Diana Borges Dock‐Nascimento, THAYSE EMANUELLI GODOY BEHNE, Mariana Borges Silva Thé, Hadassa Hillary Novaes Pereira Rodrigues, Francilene Oliveira Andreo, MARISTELA LUFT PALAURO, José Eduardo de Aguilar‐Nascimento,
ABSTRACT Objectives : to investigate the impact of oncological surgical procedures on the muscle function of patients with and without nutritional risk. Methods: cross-sectional study conducted with cancer patients undergoing major operations between July 2018 to March 2019 in Cuiabá, Mato Grosso, Brazil. Patients were assessed preoperatively for the nutritional risk by the Nutricional Risk Screening-2002, and handgrip strength (FPP) was assessed both on the pre- and 2nd and 5th postoperative days ( ...
Tópico(s): Frailty in Older Adults
2020 - Brazilian College of Surgeons | Revista do Colégio Brasileiro de Cirurgiões
Produção Nacional
Revisado por pares
Fernanda Gabriela Colombo Drumond Santos, Mariana Godoy-Leite, Eduardo Augusto Resende Penido, Kennad Alves Ribeiro, Maria da Glória Rodrigues‐Machado, Bruno Almeida Rezende,
Abstract Background Childhood obesity is a major cardiovascular risk factor because it predisposes individuals to comorbidities that are implicated in an increased risk of cardiovascular events. Its origin may be related to poor eating habits, such as the intake of foods of low nutritional value or inadequate eating behaviours related to emotional factors. This work aims to evaluate the relationship between the total body mass of children and adolescents and its association with eating habits, quality ...
Tópico(s): Health and Lifestyle Studies
2023 - BioMed Central | BMC Pediatrics
Produção Nacional
Revisado por pares
Carolina Hungaro Cunha, Debora Yuri Sato, José Maria Pereira de Godoy, Gleison Juliano da Silva Russeff, Desirée Franccini Del Frari Silva, Henrique José Pereira de Godoy, Mariana Orate Menezes da Silva, Henrique Amorim Santos, Maria de Fátima Guerreiro Godoy,
The SARS-CoV-2 disease predisposes infected individuals to thrombosis, the underlying mechanisms of which are not fully understood. The balance between pro-coagulant factors and natural coagulation inhibitors in critically ill patients with Covid-19 is fundamental to the prevention and treatment of complications. The aim of the present study was to investigate the pulmonary injury patterns in Covid-19 having higher mortality in the presence of deep vein thrombosis in comparison to patients without ...
Tópico(s): Long-Term Effects of COVID-19
2022 - Dove Medical Press | Vascular Health and Risk Management
Produção Nacional
Revisado por pares
Naiara Vieira Godoy, Mariana Gava Segatelli,
In this study, hybrid polymeric networks were prepared by hydrosilylation reaction as precursors to silicon oxycarbide (SiOC) glass.The polymeric networks were prepared from poly(methylsiloxane) (PMS) and divinylbenzene (DVB) in the 80:20 and 20:80 (PMS/DVB) compositions, with or without activated charcoal (AC), which was used as additional carbon source.Following, polymeric precursors were pyrolysed at 1000 °C, under Ar atmosphere, resulting in SiOC glasses.The effectiveness of the hydrosilylation reaction ...
Tópico(s): Glass properties and applications
2015 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Revisado por pares
William E. Magnusson, Carlos Eduardo Viveiros Grelle, Márcia C. M. Marques, Carlos Frederico Duarte Rocha, Braulio Ferreira de Souza Dias, Carla Suertegaray Fontana, Helena Godoy Bergallo, Gerhard E. Overbeck, Mariana M. Vale, Walfrido Moraes Tomás, Rui Cerqueira, Rosane G. Collevatti, Valério D. Pillar, Luiz Roberto Malabarba, Ana Carolina Borges Lins-e-Silva, Selvino Neckel‐Oliveira, Bruno Martinelli, Alberto Akama, Domingos de Jesus Rodrigues, Luís Fábio Silveira, Aldicìr Scariot, Geraldo Wilson Fernandes,
The effects of Brazil´s political crisis on biodiversity conservation are likely to be global. Brazil is not only the World´s most biodiverse nation, it is responsible for the greater part of the Amazon forest, which regulates the climate and provides rain to much of southern South America. Brazil was a World leader in satellite monitoring of land-use change, in-situ biodiversity monitoring, reduction in tropical-forest deforestation, protection of indigenous lands, and a model for other developing ...
Tópico(s): Land Use and Ecosystem Services
2018 - Frontiers Media | Frontiers in Ecology and Evolution
Produção Nacional
Revisado por pares
Louise Moraes, Andréia Vasconcelos-dos-Santos, Fernando Cleber Santana, Mariana Araya de Godoy, Paulo Henrique Rosado-de-Castro, J. Jasmin, Ricardo L. Azevedo-Pereira, W M Cintra, Emerson L. Gasparetto, Marcelo F. Santiago, Rosalia Méndez‐Otero,
Bone marrow mesenchymal stem cells (MSC) have been tested and proven effective in some neurodegenerative diseases, but their tracking after transplantation may be challenging. Our group has previously demonstrated the feasibility and biosafety of rat MSC labeling with iron oxide superparamagnetic nanoparticles (SPION). In this study, we investigated the therapeutic potential of SPION-labeled MSC in a rat model of Huntington's disease, a genetic degenerative disease with characteristic deletion of ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2012 - Elsevier BV | Stem Cell Research
Produção Nacional
Revisado por pares
Mariana Araya de Godoy, Amanda S. Souza, Mônica Lobo, Omar Vidal Kress Sampaio, Louise Moraes, Marcelo R. Baldanza, Tatiana Magri, João Pedro Saar Wernerck de Castro, Maria das Graças Tavares do Carmo, Márcia Soares-Mota, Mônica S. Rocha, Rosalia Méndez‐Otero, Marcelo F. Santiago,
There is no consensus about the effects of protein restriction on neurogenesis and behavior. Here, for the first time, we evaluated the effects of protein restriction during gestation and lactation, on the two major neurogenic regions of the adult brain, the subgranular zone (SGZ) of the hippocampal dentate gyrus and the subventricular zone (SVZ), simultaneously. We also assessed different types of behavior relevant to each region. After mating, pregnant Wistar rats were divided into a control group ( ...
Tópico(s): Anesthesia and Neurotoxicity Research
2012 - Elsevier BV | Brain Research
Produção Nacional
Revisado por pares
Marco Antônio Seiki Kadowaki, Paula M. R. Higasi, Mariana Ortiz de Godoy, Rolf A. Prade, Igor Polikarpov,
Cellobiohydrolases hydrolyze cellulose, a linear polymer with glucose monomers linked exclusively by β‐1,4 glycosidic linkages. The widespread hydrogen bonding network tethers individual cellulose polymers forming crystalline cellulose, which prevent the access of hydrolytic enzymes and water molecules. The most abundant enzyme secreted by Myceliophthora thermophila M77 in response to the presence of biomass is the cellobiohydrolase Mt Cel7A, which is composed by a GH 7‐catalytic domain ( CD ), a linker, ...
Tópico(s): Enzyme Production and Characterization
2017 - Wiley | FEBS Journal
Produção Nacional
Revisado por pares
Mariana Araya de Godoy, Leonardo Saraiva, Luiza Carvalho, Andréia Vasconcelos-dos-Santos, Hellen J. V. Beiral, Alane Bernardo Ramos, Livian R. de Paula Silva, Renata B. Leal, Victor Hugo S. Monteiro, Carolina V. Braga, Carlla Assis Araújo-Silva, Leandro Cardoso Sinis, Victor Bodart‐Santos, Taís Hanae Kasai-Brunswick, Carolina de Lima Alcantara, Ana Paula C. A. Lima, Narcisa L. da Cunha-e Silva, Antônio Galina, Adalberto Vieyra, Fernanda G. De Felice, Rosalia Méndez‐Otero, Sérgio T. Ferreira,
Alzheimer’s disease (AD) is a disabling and highly prevalent neurodegenerative condition, for which there are no effective therapies. Soluble oligomers of the amyloid-β peptide (AβOs) are thought to be proximal neurotoxins involved in early neuronal oxidative stress and synapse damage, ultimately leading to neurodegeneration and memory impairment in AD. The aim of the current study was to evaluate the neuroprotective potential of mesenchymal stem cells (MSCs) against the deleterious impact of AβOs ...
Tópico(s): Extracellular vesicles in disease
2017 - Elsevier BV | Journal of Biological Chemistry
Produção Nacional
Revisado por pares
Marco Antônio Seiki Kadowaki, Mariana Ortiz de Godoy, Patricia S. Kumagai, Antonio J. Costa‐Filho, Andrew J. Mort, Rolf A. Prade, Igor Polikarpov,
Myceliophthora thermophyla is a thermophilic industrially relevant fungus that secretes an assortment of hydrolytic and oxidative enzymes for lignocellulose degradation. Among them is glyoxal oxidase (MtGLOx), an extracellular oxidoreductase that oxidizes several aldehydes and α-hydroxy carbonyl substrates coupled to the reduction of O2 to H2O2. This copper metalloprotein belongs to a class of enzymes called radical copper oxidases (CRO) and to the “auxiliary activities” subfamily AA5_1 that is based ...
Tópico(s): Biofuel production and bioconversion
2018 - Multidisciplinary Digital Publishing Institute | Catalysts
Produção Nacional
Revisado por pares
Victor Bodart‐Santos, Luiza Carvalho, Mariana Araya de Godoy, André F. Batista, Leonardo Saraiva, Luize Goncalves Lima, Carla Andreia Abreu, Fernanda G. De Felice, Antônio Galina, Rosalia Méndez‐Otero, Sérgio T. Ferreira,
Abstract Background Mesenchymal stem cells (MSCs) have been explored as promising tools for treatment of several neurological and neurodegenerative diseases. MSCs release abundant extracellular vesicles (EVs) containing a variety of biomolecules, including mRNAs, miRNAs, and proteins. We hypothesized that EVs derived from human Wharton’s jelly would act as mediators of the communication between hMSCs and neurons and could protect hippocampal neurons from damage induced by Alzheimer’s disease-linked ...
Tópico(s): Circular RNAs in diseases
2019 - BioMed Central | Stem Cell Research & Therapy
Produção Nacional
Revisado por pares
Teresa Puig‐Pijuan, Mariana Araya de Godoy, Luiza Carvalho, Victor Bodart‐Santos, Rafael Soares Lindoso, Pedro M. Pimentel‐Coelho, Rosalia Méndez‐Otero,
Aim: Mesenchymal stem cells (MSCs) have neuroprotective and immunomodulatory properties, which are partly mediated by extracellular vesicles (EVs) secretion. We aimed to evaluate the effects of human Wharton's jelly-derived MSCs (WJ-MSCs) and their EVs on rat hippocampal cultures subjected to hydrogen peroxide (H2O2). Materials & methods: Hippocampal dissociated cultures were either co-cultured with WJ-MSCs or treated with their EVs prior to H2O2 exposure and reactive oxygen species levels and cell viability ...
Tópico(s): MicroRNA in disease regulation
2020 - Future Science Ltd | Future Science OA
Produção Nacional
Revisado por pares
G.D. Noske, Ellen de Souza Silva, Mariana Ortiz de Godoy, Isabela Dolci, R.S. Fernandes, Rafael V. C. Guido, Peter Sjö, Glaucius Oliva, André S. Godoy,
SARS-CoV-2 is the causative agent of COVID-19. The main viral protease (Mpro) is an attractive target for antivirals. The clinically approved drug nirmatrelvir and the clinical candidate ensitrelvir have so far showed great potential for treatment of viral infection. However, the broad use of antivirals is often associated with resistance generation. Herein, we enzymatically characterized 14 naturally occurring Mpro polymorphisms that are close to the binding site of these antivirals. Nirmatrelvir ...
Tópico(s): Research on Leishmaniasis Studies
2023 - Elsevier BV | Journal of Biological Chemistry
Marco Zarattini, Massimiliano Corso, Marco Antônio Seiki Kadowaki, Antonielle Vieira Monclaro, Silvia Magri, Irma Milanese, Sylvie Jolivet, Mariana Ortiz de Godoy, Christian Hermans, Mathilde Fagard, David Cannella,
Lytic Polysaccharide Monooxygenases (LPMOs) are powerful redox enzymes able to oxidatively cleave recalcitrant polysaccharides. Widely conserved across biological kingdoms, LPMOs of the AA9 family are deployed by phytopathogens to deconstruct cellulose polymers. In response, plants have evolved sophisticated mechanisms to sense cell wall damage and thus self-triggering Damage Triggered Immunity responses. Here, we show that Arabidopsis plants exposed to LPMO products triggered the innate immunity ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2021 - Nature Portfolio | Communications Biology
Produção Nacional
Revisado por pares
Milena Soriano Marcolino, Magda Carvalho Pires, Lucas Emanuel Ferreira Ramos, Rafael T. Silva, Luana Martins Oliveira, Rafael Lima Rodrigues de Carvalho, Rodolfo Lucas Silva Mourato, Adrián Sánchez‐Montalvá, Berta Raventós, Fernando Anschau, José Miguel Chatkin, Matheus Carvalho Alves Nogueira, Milton Henriques Guimarães Júnior, Giovanna Grünewald Vietta, Helena Duani, Daniela Ponce, Patrícia Klarmann Ziegelmann, Luís César de Castro, Karen Brasil Ruschel, Christiane Corrêa Rodrigues Cimini, Saionara Cristina Francisco, Maiara Anschau Floriani, Guilherme Fagundes Nascimento, Bárbara Lopes Farace, Luanna S. Monteiro, Maíra Viana Rego Souza-Silva, Thaís Lorenna Souza Sales, Karina Paula Medeiros Prado Martins, Israel Júnior Borges do Nascimento, Tatiani Oliveira Fereguetti, Daniel T. M. O. Ferrara, Fernando Antônio Botoni, Ana Paula Beck da Silva Etges, Alexandre Vargas Schwarzbold, Amanda O. Maurílio, Ana Luiza Bahia Alves Scotton, André P. Weber, André S. Costa, Andressa Barreto Glaeser, Angélica Aparecida Coelho Madureira, Angelinda Rezende Bhering, Bruno Mateus de Castro, Carla Thais C.A. da Silva, Carolina Marques Ramos, Caroline Danubia Gomes, Cíntia Alcântara de Carvalho, Daniel Vitório Silveira, Edilson Cezar, Elayne Crestani Pereira, Emanuele Marianne Souza Kroger, Felipe Barbosa Vallt, Fernanda Barbosa Lucas, Fernando Graça Aranha, Frederico Bartolazzi, Gabriela Petry Crestani, Gisele Alsina Nader Bastos, Glícia Cristina de Castro Madeira, Helena Carolina Noal, Heloísa Reniers Vianna, Henrique Cerqueira Guimarães, Isabela Moraes Gomes, Israel Molina, Joanna d’Arc Lyra Batista, Joice Coutinho de Alvarenga, Júlia di Sabatino Santos Guimarães, Júlia Drumond Parreiras de Morais, Juliana Machado-Rugolo, Karen Cristina J.R. Pontes, Kauane Aline Maciel dos Santos, Leonardo Seixas de Oliveira, Lílian Santos Pinheiro, Liliane Souto Pacheco, Lucas de Deus Sousa, Luciana Siuves Ferreira Couto, Luciane Kopittke, Luis Cesar Souto de Moura, Luísa Elem Almeida Santos, Máderson A.S. Cabral, Maíra Dias Souza, Marcela Gonçalves Trindade Tofani, Marcelo Carneiro, Maria Angélica Pires Ferreira, Maria Aparecida Camargos Bicalho, Maria Clara Pontello Barbosa Lima, Mariana Frizzo de Godoy, Marília Mastrocolla de Almeida Cardoso, Meire Pereira de Figueiredo, Natália C.S. Sampaio, Natália L. Rangel, Natália T. Crespo, Neimy Ramos de Oliveira, Pedro Ledic Assaf, Petrônio José de Lima Martelli, Rafaela Santos Charão de Almeida, Raphael Castro Martins, Raquel Lutkmeier, Reginaldo Aparecido Valácio, Renan Goulart Finger, Ricardo Bertoglio Cardoso, Roberta Pozza, Roberta Xavier Campos, Rochele Mosmann Menezes, Roger Mendes de Abreu, Rufino de F. Silva, Silvana Mangeon Mereilles Guimarães, Silvia Ferreira Araújo, Susany Anastácia Pereira, Talita Fischer Oliveira, Tatiana Kurtz, Thainara Conceição de Oliveira, Thaíza Simônia M.A. Araújo, Thulio Henrique Oliveira Diniz, Veridiana Baldon dos Santos, Virgínia Mara Reis Gomes, Vitor Augusto Lima do Vale, Yuri Carlotto Ramires, Eric Boersma, Carísi Anne Polanczyk,
The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones.Consecutive patients (≥ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed ...
Tópico(s): Sepsis Diagnosis and Treatment
2021 - Elsevier BV | International Journal of Infectious Diseases
Produção Nacional
Revisado por pares
Marjorie Caroline Liberato Cavalcanti Freire, G.D. Noske, Natália Vitória Bitencourt, Paulo R. S. Sanches, Norival A. Santos‐Filho, Victor O. Gawriljuk, Eduardo Pereira de Souza, Victor H. R. Nogueira, Mariana Ortiz de Godoy, A.M. Nakamura, R.S. Fernandes, André S. Godoy, María A. Juliano, Bianca de Miranda Peres, Cecília Gomes Barbosa, Carolina Borsoi Moraes, Lúcio H. Freitas-Júnior, Eduardo Maffud Cilli, Rafael V. C. Guido, Glaucius Oliva,
The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years, peptide-based therapeutics have been widely studied and developed to treat infectious diseases, including viral infections. Herein, the antiviral effects of the lysine linked dimer des-Cys11, Lys12,Lys13-(pBthTX-I)2K ((pBthTX-I)2K)) and derivatives against SARS-CoV-2 are reported. The lead peptide (pBthTX-I)2K and derivatives showed attractive inhibitory ...
Tópico(s): vaccines and immunoinformatics approaches
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Revisado por pares
José Maria Pereira de Godoy, Flávia Mariana Valente, Lina Maria O. Azoubel, Moacir Fernandes de Godoy,
Aim The aim of this study was to investigate the effects of manual and mechanical lymph drainage on the bioelectrical composition of body tissues of patients with lymphoedema of the lower limbs. Method Twenty-one patients with lymphoedema of one leg were evaluated using single frequency bioelectrical impedance with four electrodes (SF-BIA4) immediately before and after a combination of manual and mechanical lymph drainage. Statistical analysis used the two-tailed paired t-test with an alpha error ...
Tópico(s): Body Contouring and Surgery
2011 - SAGE Publishing | Phlebology The Journal of Venous Disease
Produção Nacional
Revisado por pares
Marco Antônio Seiki Kadowaki, Paula M. R. Higasi, Mariana Ortiz de Godoy, Evandro Ares de Araújo, André S. Godoy, Rolf A. Prade, Igor Polikarpov,
Background Fungal aryl-alcohol oxidases (AAOx) are extracellular flavoenzymes that belong to glucose-methanol-choline oxidoreductase family and are responsible for the selective conversion of primary aromatic alcohols into aldehydes and aromatic aldehydes to their corresponding acids, with concomitant production of hydrogen peroxide (H2O2) as by-product. The H2O2 can be provided to lignin degradation pathway, a biotechnological property explored in biofuel production. In the thermophilic fungus Thermothelomyces ...
Tópico(s): Enzyme Catalysis and Immobilization
2020 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Marco Antônio Seiki Kadowaki, Silvia Magri, Mariana Ortiz de Godoy, Antonielle Vieira Monclaro, Marco Zarattini, David Cannella,
Lytic polysaccharide monooxygenases (LPMOs) are industrially important enzymes able to enhance the enzymatic lignocellulose saccharification in synergism with classical glycoside hydrolases. Fungal LPMOs have been classified as AA9, AA11, and AA13-16 families showing a diverse specificity for substrates such as soluble and insoluble beta-glucans, chitin, starch, and xylan, besides cellulose. These enzymes are still not fully characterized, and for example this is testify by their mechanism of oxidation ...
Tópico(s): Enzyme Catalysis and Immobilization
2020 - Elsevier BV | Enzyme and Microbial Technology
Ricardo Godoy, Elizabeth Goodman, Richard Levins, Mariana Caram, Craig Seyfried,
Tópico(s): Employment and Welfare Studies
2006 - Elsevier BV | Economics & Human Biology