Luis F. Pacheco, Mariana Altrichter, Harald Beck, Damayanti Buchori, Erasmus H. Owusu,
Tópico(s): Climate Change Policy and Economics
2018 - Oxford University Press | BioScience
Produção Nacional
Revisado por pares
Mohammad Saeid Rezaee‐Zavareh, Yee Hui Yeo, Tielong Wang, Zhiyong Guo, Parissa Tabrizian, Stephen C. Ward, Fatma Barakat, Tarek Hassanein, Shravan Dave, Veeral Ajmera, Sherrie Bhoori, Vincenzo Mazzaferro, David M. Chascsa, Margaret C. Liu, Elizabeth S. Aby, John R. Lake, Miguel Sogbe, Bruno Sangro, Maen Abdelrahim, Abdullah Esmail, Andreas Schmiderer, Yasmina Chouik, Mark Rudolph, Davendra Sohal, Héloïse Giudicelli, Manon Allaire, Mehmet Akce, Jessica Guadagno, Clara Tow, Hatef Massoumi, Paolo De Simone, Elise Kang, Robyn D. Gartrell, Mercedes Martínez, Ricardo Paz‐Fumagalli, Beau B. Toskich, Nguyen H. Tran, Gabriela Azevedo Solino, Mariana Poltronieri Pacheco, Richard Kalman, Vatche G. Agopian, Neil Mehta, Neehar D. Parikh, Amit G. Singal, Ju Dong Yang,
Highlights•The published literature reports an acceptable risk of allograft rejection, cancer recurrence, and mortality among patients with HCC who receive ICIs prior to liver transplantation.•Each 10-year increase in a patient's age and one-week increase in ICI washout period was associated with 28% (1, 47 %) and 8% (1, 14 %) reduced chance of allograft rejection, respectively.•A median ICI washout period of 94 days or more was associated with a risk of allograft rejection ≤ 20%.•Over 80% of allograft rejection ...
Tópico(s): Hepatitis C virus research
2024 - Elsevier BV | Journal of Hepatology
Produção Nacional
Revisado por pares
Gabriela Abdalla, Cassamo U. Mussagy, Giovana Sant’Ana Pegorin Brasil, Mateus Scontri, J Sasaki, Yanjin Su, Camila Calderan Bebber, Raildis Ribeiro Rocha, Ana Paula de Sousa Abreu, Rogério Penna Gonçalves, Betina Sayeg Burd, Mariana Ferraz Pacheco, Karoline Mansano Romeira, Flávio Pereira Picheli, Nayrim Brizuela Guerra, Neda Farhadi, Juliana Ferreira Floriano, Samuel C. Forster, Siqi He, Huu Tuan Nguyen, Arne Peirsman, Zuzana Tirpáková, Shuyi Huang, Mehmet R. Dokmeci, Ernando Silva Ferreira, Lindomar Soares dos Santos, Rodolfo Debone Piazza, Rodrigo Fernando Costa Marques, Alejandro Goméz, Glaucio Ribeiro Silva, Vadim Jucaud, Bingbing Li, Henriette Monteiro Cordeiro de Azeredo, Rondinelli Donizetti Herculano,
Films and coatings manufactured with bio-based renewable materials, such as biopolymers and essential oils, could be a sustainable and eco-friendly alternative for protecting and preserving agricultural products. In this work, we developed films and coatings from pectin and chitosan to protect strawberries (Fragaria x ananassa Duch.) from spoilage and microbial contamination. We developed three coatings containing equal amounts of glycerol and Sicilian lemon essential oil (LEO) nanoemulsion. We identified ...
Tópico(s): Essential Oils and Antimicrobial Activity
2023 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Mayara Hilgert Pacheco, Mariana Sversut Gibin, Marcelo Antônio de Souza Silva, Guilherme Henrique Montagnini, Ronaldo Celso Viscovini, A. Steimacher, Franciana Pedrochi, Vitor Santaella Zanuto, Robson Ferrari Muniz,
This paper reports on a study aimed at investigating the physical properties and radiation shielding capability of a low-cost, high-transparency silicate glassy system reinforced with barium oxide. The prepared glasses' elementary and modified network structures were analyzed using X-ray diffraction and Raman spectroscopy, confirming their glass nature and revealing the progressive network depolymerization with BaO inclusion. Differential scanning calorimetry was employed to determine the glass ...
Tópico(s): Glass properties and applications
2023 - Elsevier BV | Journal of Alloys and Compounds
Felipe Melo-González, Jorge A. Soto, Liliana A González, Jorge Onrubia Fernández, Luisa F. Duarte, Bárbara M. Schultz, Nicolás M. S. Gálvez, Gaspar A. Pacheco, Mariana Ríos, Yaneisi Vázquez, Daniela Rivera-Pérez, Daniela Moreno-Tapia, Carolina Iturriaga, Omar P. Vallejos, Roslye V. Berríos-Rojas, Guillermo Hoppe-Elsholz, Marcela Urzúa, Nicole Bruneau, Rodrigo Fasce, Judith Mora, Alba Grifoni, Alessandro Sette, Daniela Weiskopf, Gang Zeng, Weining Meng, José Vicente González-Aramúndiz, Pablo A. González, Katia Abarca, Eugenio Ramı́rez, Alexis M. Kalergis, Susan M. Bueno,
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible of the current pandemic ongoing all around the world. Since its discovery in 2019, several circulating variants have emerged and some of them are associated with increased infections and death rate. Despite the genetic differences among these variants, vaccines approved for human use have shown a good immunogenic and protective response against them. In Chile, over 70% of the vaccinated population is ...
Tópico(s): Vaccine Coverage and Hesitancy
2021 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Cristiana Maria Pedroso Yoshida, Murilo Santos Pacheco, Mariana Agostini de Moraes, Patrícia Santos Lopes, Patrícia Severino, Eliana B. Souto, Classius Ferreira da Silva,
Chitosan films have been extensively studied as dressings in formulations for the treatment of chronic wounds. The incorporation of aloe vera (Aloe barbadensis Miller) into chitosan dressings could potentialize the healing process since aloe vera shows several pharmacological activities. This work aimed to evaluate the effect of aloe vera and chitosan concentrations on the physicochemical properties of the developed films. The films were obtained by casting technique and characterized with respect ...
Tópico(s): Essential Oils and Antimicrobial Activity
2021 - Multidisciplinary Digital Publishing Institute | Polymers
C. Hernández-Aguilar, A. Domínguez-Pacheco, Mariana Palma-Tenango, C. Valderrama-Bravo, Marcos Soto‐Hernández, A. Cruz–Orea, José Ordoñez-Miranda,
Tópico(s): Seed and Plant Biochemistry
2020 - Springer Science+Business Media | Journal of Plant Growth Regulation
C. Hernández-Aguilar, A. Domínguez-Pacheco, Mariana Palma-Tenango, C. Valderrama-Bravo, Marcos Soto‐Hernández, A. Cruz–Orea, José Ordoñez-Miranda,
The pro-health action of germinated lentils could be useful to be added with wheat flour in the production of box bread. In this work, we spectroscopically evaluate the germinated and non-germinated lentils, and use them at the concentrations of 5 and 10% for the production of box bread. The chemical and physical tests of the bread and its determination of phenolic acids and flavonoids (by HPLC) were also performed. As well as the evaluation of the quality of flour and dough used to produce the bread ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2019 - Springer Science+Business Media | Journal of Food Science and Technology
Produção Nacional
Revisado por pares
Fernanda Saloum Neves Manta, Raquel Rodrigues Barbieri, Suelen Justo Maria Moreira, Paulo T. S. Santos, José A. C. Nery, Nádia Cristina Düppre, Anna Maria Sales, Antônio Guilherme Pacheco, Mariana A. Hacker, Alice Machado, Euzenir Nunes Sarno, Milton Ozório Moraes,
Abstract Household contacts (HHC) of leprosy patients exhibit high-risk of developing leprosy and contact tracing is helpful for early diagnosis. From 2011 to 2018,2,437 HHC were examined in a clinic in Rio de Janeiro, Brazil and 16S qPCR was used for diagnosis and monitoring of contacts. Fifty-four HHCs were clinically diagnosed with leprosy at intake. Another 25 exhibited leprosy-like skin lesions at intake, 8 of which were confirmed as having leprosy (50% of which were qPCR positive) and 17 of ...
Tópico(s): Dermatological diseases and infestations
2019 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Isabel Cristina Olegário, Anna Luisa de Brito Pacheco, Mariana Pinheiro Araújo, Nathalia de Miranda Ladewig, Clarissa Calil Bonifácio, José Carlos Pettorossi Imparato, Daniela Prócida Raggio,
The high costs of the worldwide recommended GICs might be a barrier for the implementation of ART. To overcome this problem, low cost GIC are used even though there is a lack of evidence for the survival rate of restorations.To evaluate the performance of low-cost GICs used on occlusal ART restorations after one year.A total of 150 primary molars in 150 children with occlusal caries lesions were selected in 4-8 year-old children. The patients were randomly allocated in three groups: G1-GC Gold Label ...
Tópico(s): Dental materials and restorations
2016 - Elsevier BV | Journal of Dentistry
Produção Nacional
Revisado por pares
Priscila F. M. Lopes, S. Pacheco, Mariana Clauzet, Renato Azevedo Matias Silvano, Alpina Begossi,
Tópico(s): Coastal and Marine Management
2015 - Elsevier BV | Ecosystem Services
Cristiana Lima Dora, Luis Felipe Costa Silva, Letícia Mazzarino, Jarbas Mota Siqueira, Daniel Fernandes, Letícia Kramer Pacheco, Mariana Franzoni Maioral, Maria Cláudia Santos‐Silva, Ana Luiza Muccillo‐Baisch, Jamil Assreuy, Elenara Lemos‐Senna,
Quercetin is a natural compound that has several biological activities including anticancer activity. However, the use of this drug has been limited mostly because of its poor water solubility and low bioavailability. Therefore, the development of quercetin-loaded nanocarrier systems may be considered a promising advance to exploit its therapeutic properties in clinical setting including cancer treatment. This study evaluates the effect of orally administered nanosized emulsion containing quercetin ( ...
Tópico(s): Computational Drug Discovery Methods
2015 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology
Produção Nacional
Revisado por pares
Marcílio Cunha‐Filho, Carmen Alvarez‐Lorenzo, Ramón Martínez‐Pacheco, Mariana Landín,
This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral β -lapachone ( β LAP). Pluronic dispersions prepared at various concentrations in the absence and the presence of ethanol and randomly methylated β -cyclodextrin (RM β CD) were characterized regarding their rheological properties, drug solubilization capacity, and in vitro release. Pluronic F127 (18–23%) formulations combined high ...
Tópico(s): Pharmacological Effects of Natural Compounds
2012 - Hindawi Publishing Corporation | The Scientific World JOURNAL
Marcílio Cunha‐Filho, Ramón Martínez‐Pacheco, Mariana Landín,
Tópico(s): Cancer therapeutics and mechanisms
2008 - Elsevier BV | European Journal of Pharmaceutics and Biopharmaceutics
Produção Nacional
Revisado por pares
Daniela Zanardi, Daniel Holthausen Nunes, Alexsandra da Silva Pacheco, Mariana Quirino Tubone, Jorge José de Souza Filho,
FUNDAMENTOS: As onicomicoses são infecções fúngicas responsáveis por 15 a 40% das doenças ungueais. Apesar do pleno conhecimento de seus agentes etiológicos e do surgimento de inúmeros medicamentos antifúngicos, mantêm-se as dificuldades para se estabelecer diagnóstico correto. OBJETIVOS: Comparar o exame micológico direto, o histopatológico e a cultura dos pacientes com suspeita de onicomicose e verificar a sensibilidade e especificidade de cada método. MÉTODO: Foram selecionados 40 pacientes com ...
Tópico(s): Fungal Infections and Studies
2008 - Elsevier BV | Anais Brasileiros de Dermatologia
Marcílio Cunha‐Filho, Ramón Martínez‐Pacheco, Mariana Landín,
The objective of the present study was to evaluate the compatibility of the β-lapachone (βLAP), an antitumoral drug in clinical phase, with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Differential scanning calorimetry (DSC) was used for a first screening to find small variations in peak temperatures and/or their associated enthalpy for six drug/excipient combinations (magnesium stearate, sodium estearyl fumarate, dicalcium ...
Tópico(s): Synthesis and bioactivity of alkaloids
2007 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis
Marcílio Cunha‐Filho, B. Dacunha-Marinho, Juan J. Torres‐Labandeira, Ramón Martínez‐Pacheco, Mariana Landín,
The purpose of this research was to explore the utility of β cyclodextrin (βCD) and β cyclodextrin derivatives (hydroxypropyl-β-cyclodextrin [HPβCD], sulfobutylether-β-CD [SB\CD], and a randomly methylated-β-CD [RMβCD]) to form inclusion complexes with the antitumoral drug, β-lapachone (βLAP), in order to overcome the problem of its poor water solubility. RMβCD presented the highest efficiency for βLAP solubilization and was selected to develop solid-state binary systems. Differential scanning calorimetry ( ...
Tópico(s): Microwave-Assisted Synthesis and Applications
2007 - Springer Science+Business Media | AAPS PharmSciTech
Miguel Viveiros, Clara Leandro, Liliana Rodrigues, J. M. Das Neves Almeida, Rosário Bettencourt, Isabel Couto, Lurdes Carrilho, José Diogo, Ana Mafalda Fonseca, Luís Lito, João Lopes, Teresa Pacheco, Mariana Pessanha, Judite Quirim, Luísa Sancho, Max Salfinger, Leonard Amaral,
ABSTRACT The INNO-LiPA Rif.TB assay for the identification of Mycobacterium tuberculosis complex strains and the detection of rifampin (RIF) resistance has been evaluated with 360 smear-positive respiratory specimens from an area of high incidence of multidrug-resistant tuberculosis (MDR-TB). The sensitivity when compared to conventional identification/culture methods was 82.2%, and the specificity was 66.7%; the sensitivity and specificity were 100.0% and 96.9%, respectively, for the detection of ...
Tópico(s): Pneumonia and Respiratory Infections
2005 - American Society for Microbiology | Journal of Clinical Microbiology
Produção Nacional
Revisado por pares
Marcílio Cunha‐Filho, Ana Estévez‐Braun, Elisa Pérez-Sacau, Magdalena Echezarreta-López, Ramón Martínez‐Pacheco, Mariana Landín,
The purpose of this work was to study the chemical stability of the new antitumoral β-lapachone (βLAP) to determine the degradation pathway/s of the molecule and the degradation kinetics in addition to identifying several degradation products.Samples of βLAP in solution were stored under conditions of darkness and illumination at 40°C at which the pseudo-first order rate constants for the βLAP degradation were determined. Furthermore, drug degraded solutions were concentrated and purified using Sephadex ...
Tópico(s): Synthesis and Biological Evaluation
2011 - Oxford University Press | Journal of Pharmacy and Pharmacology
Produção Nacional
Revisado por pares
Marcílio Cunha‐Filho, Ramón Martínez‐Pacheco, Mariana Landín,
Abstract Objectives In this work, the effects of several technological factors on the stability of β-lapachone (βLAP) in solution and in the solid state were investigated. Methods The effects of relative humidity and light on the stability of βLAP in the solid state were studied. Samples were characterized by liquid chromatography, thermal analysis, X-ray powder diffraction and optical microscopy. In solution, the effects of light conditions and additives (cyclodextrins) were also evaluated. Molecular ...
Tópico(s): Multicomponent Synthesis of Heterocycles
2013 - Oxford University Press | Journal of Pharmacy and Pharmacology
Produção Nacional
Revisado por pares
Isabela Pacheco Borges, Mariana Ferreira Silva, Fernanda Maria Santiago, Lucas Silva de Faria, Álvaro Ferreira Júnior, Rafaela José da Silva, Mônica Soares Costa, Vitor de Freitas, Kelly Aparecida Geraldo Yoneyama, Eloísa Amália Vieira Ferro, Daiana Silva Lopes, Renata Santos Rodrigues, Veridiana de Melo Rodrigues,
Activities of phospholipases (PLAs) have been linked to pathogenesis in various microorganisms, and implicated in cell invasion and so the interest in these enzymes as potential targets that could contribute to the control of parasite survival and proliferation. Chicken eggs immunized with BnSP-7, a Lys49 phospholipase A2 (PLA2) homologue from Bothrops pauloensis snake venom, represent an excellent source of polyclonal antibodies with potential inhibitory activity on parasite PLAs. Herein, we report ...
Tópico(s): Rabies epidemiology and control
2018 - Elsevier BV | International Journal of Biological Macromolecules
Joy Banks, Taucia González, Carlyn Mueller, Mariana Pacheco, LaRon A. Scott, Audrey A. Trainor,
Qualitative research (QR) has gained visibility and acceptance in the field of special education due to early efforts to identify quality indicators focused on technical and methodological aspects of QR. Whereas these indicators focused on credibility and trustworthiness of data, this article articulates additional QR quality indicators to enhance the value and power of researcher reflexivity as a means to expand the capacity of purpose- and equity-driven special education research. First, the need ...
Tópico(s): Educational Assessment and Improvement
2023 - SAGE Publishing | Exceptional Children
João Guerreiro, Mariana Pacheco,
An increasing interest in environmental problems around the world has significantly expanded the demand for green goods, transforming green marketing into an effective tool for businesses to achieve competitive advantage. Yet, as more firms become aware of this strategic advantage, greenwashing activities can also flourish, and customers grow more cautious about green efforts by firms. The present research examines how greenwashing expectations of customers affect their green buying decisions by ...
Tópico(s): Digital Marketing and Social Media
2021 - Multidisciplinary Digital Publishing Institute | Sustainability
Maciej Szydłowski, Filip Garbicz, Ewa Jabłońska, Patryk Górniak, Dorota Komar, Beata Pyrzyńska, Kamil Bojarczuk, Monika Prochorec–Sobieszek, Anna Szumera‐Ciećkiewicz, Grzegorz Rymkiewicz, Magdalena Cybulska, Małgorzata Statkiewicz, Marta Gajewska, Michał Mikula, Aniela Gołas, J Domagała, Magdalena Winiarska, Agnieszka Graczyk‐Jarzynka, Emilia Białopiotrowicz, Anna Polak, Joanna Barankiewicz, Bartosz Puła, Michał Pawlak, Dominika Nowis, Jakub Gołąb, Andrea Tomirotti, Krzysztof Brzózka, Mariana Pacheco‐Blanco, Kristýna Kupcová, Michael R. Green, Ondřej Havránek, Bjoern Chapuy, Przemysław Juszczyński,
Abstract The family of PIM serine/threonine kinases includes three highly conserved oncogenes, PIM1, PIM2, and PIM3, which regulate multiple prosurvival pathways and cooperate with other oncogenes such as MYC. Recent genomic CRISPR-Cas9 screens further highlighted oncogenic functions of PIMs in diffuse large B-cell lymphoma (DLBCL) cells, justifying the development of small-molecule PIM inhibitors and therapeutic targeting of PIM kinases in lymphomas. However, detailed consequences of PIM inhibition ...
Tópico(s): Multiple Myeloma Research and Treatments
2021 - American Association for Cancer Research | Cancer Research
Mariana Pacheco, Colleen Hamilton,
Dual language immersion (DLI) education opens possibilities to leverage Latina/o/x bilingual students’ borderlands subjectivities and sensitivities. Yet persistent hegemonic discourses and the instantiation of linguistic and ideological borders in schools denigrate these sensibilities. By drawing on the concepts of bilanguaging and bilanguaging love (Mignolo, 2012), in this study the researchers examine the embodied epistemologies and knowledges a group of Latina/o/x students made visible as they ...
Tópico(s): EFL/ESL Teaching and Learning
2020 - Wiley | TESOL Quarterly
Dana Pru̇ková, Ladislav Anděra, Zuzana Nahácka, Jana Karolová, Michael Svatoň, Magdalena Klánová, Ondřej Havránek, J. Soukup, Karla Svobodová, Zuzana Zemanová, Diana Tušková, Eva Pokorná, Karel Helman, Kristina Forsterová, Mariana Pacheco‐Blanco, Petra Vočková, Adéla Berková, Eva Froňková, Marek Trněný, Pavel Klener,
Abstract Purpose: Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over)expression of BCL2. A BCL2-targeting drug, venetoclax, has promising anticancer activity in MCL. We analyzed molecular mechanisms of venetoclax resistance in MCL cells and tested strategies to overcome it. Experimental Design: We confirmed key roles of proapoptotic proteins BIM and NOXA in mediating venetoclax-induced cell death in MCL. Both BIM and NOXA are, however, differentially ...
Tópico(s): Cancer-related gene regulation
2019 - American Association for Cancer Research | Clinical Cancer Research
Joanna Latasiewicz, Annette Artz, Jing Ding, Mariana Pacheco Blanco, S. Currie, Martha Velázquez Avila, Michael Schnoor, Dietmar Vestweber,
Neutrophil extravasation is a critical step of the innate immune system's response to inflammation. This multistep process is tightly regulated by adhesion and signaling molecules in the endothelium and neutrophils. Activation of the β2 integrin LFA-1 is critical for adhesion of leukocytes to postcapillary venules. This step requires coordinated activation of signaling pathways in chemokine-stimulated neutrophils, including GTPase activation and cytoskeletal remodeling, leading to conformational ...
Tópico(s): Blood disorders and treatments
2017 - Oxford University Press | Journal of Leukocyte Biology
Debashree Goswami, Sigrid März, Yu‐Tung Li, Annette Artz, Kerstin Schäfer, Ruth Seelige, Mariana Pacheco‐Blanco, Jing Ding, M. Gabriele Bixel, Masatake Araki, Kimi Araki, Ken‐ichi Yamamura, Dietmar Vestweber,
Key Points Only CD99 on endothelial cells, not on neutrophils, participates in neutrophil extravasation in vivo. A new function was found for CD99: support of chemokine-induced β2-integrin activation and neutrophil arrest by binding to PILR.
Tópico(s): Immune Response and Inflammation
2017 - Elsevier BV | Blood
Produção Nacional
Revisado por pares
Marco Túlio Pacheco Coelho, Mariana Raniero, Marina Isidoro Silva, Érica Hasui,
In the current scenario of human transformation of natural landscapes, fragmentation and habitat loss is considered one of the major threats to biodiversity. The characteristics of altered landscapes and remaining habitat patches influence the persistence of species and, as a direct consequence, the functioning of ecological processes. The main focus of studies at landscape scale is to understand how human modifications in natural areas lead to changes in abundance and richness of species. However, ...
Tópico(s): Species Distribution and Climate Change
2016 - Wilson Ornithological Society | The Wilson Journal of Ornithology
Érika González-Domínguez, Ángeles Domínguez‐Soto, Concha Nieto, José Luis Flores-Sevilla, Mariana Pacheco‐Blanco, Victoria Campos‐Peña, Marco Antonio Meraz‐Ríos, Miguel A. Vega, Ángel L. Corbí, Carmen Sánchez‐Torres,
Human CD14(++)CD16(-) and CD14(+/lo)CD16(+) monocyte subsets comprise 85 and 15% of blood monocytes, respectively, and are thought to represent distinct stages in the monocyte differentiation pathway. However, the differentiation fates of both monocyte subsets along the macrophage (Mϕ) lineage have not yet been elucidated. We have now evaluated the potential of CD14(++) CD16(-) and CD16(+) monocytes to differentiate and to be primed toward pro- or anti-inflammatory Mϕs upon culture with GM-CSF or ...
Tópico(s): TGF-β signaling in diseases
2016 - American Association of Immunologists | The Journal of Immunology