Alexis Parada‐Bustamante, Pedro A. Orihuela, Mariana Ríos, Patricia A. Navarrete-Gómez, Catherina A. Cuevas, Luís Velásquez, Manuel Villalón, Horacio B. Croxatto,
Estradiol (E(2)) accelerates oviductal egg transport through intraoviductal nongenomic pathways in cyclic rats and through genomic pathways in pregnant rats. This shift in pathways, which we have provisionally designated as intracellular path shifting (IPS), is caused by mating-associated signals and represents a novel and hitherto unrecognized phenomenon. The mechanism underlying IPS is currently under investigation. Using microarray analysis, we identified several genes the expression levels of ...
Tópico(s): Reproductive Biology and Fertility
2007 - Oxford University Press | Biology of Reproduction
Mariana Ríos, Marcela A. Hermoso, Trinidad Sánchez, Horacio B. Croxatto, Manuel Villalón,
The oviducal transport of eggs to the uterus normally takes 72–96 h in the rat, but this is reduced to less than 20 h after a single injection of oestradiol (E2). This accelerated transport is associated with an increased frequency of pendular movements in the isthmic segment of the oviduct, with increased levels of the gap junction (GJ) component Connexin (Cx) 43, and is antagonised by progesterone (P). In the present study, we investigated the effect of these hormones on the instant and directional ...
Tópico(s): Bee Products Chemical Analysis
2007 - CSIRO Publishing | Reproduction Fertility and Development
Mariana Ríos, Jorge Onrubia Fernández, Piedad Roldan Jaramillo, Vanessa Paredes, J L Sanchez, V. Alberto Laguna-Torres, Jean K. Carr, Eugenio Ramı́rez,
We examined the genetic makeup of 221 HIV-1 strains from Chilean persons living with HIV/AIDS by HMA and DNA sequencing of the env gene: 143 cases were infected by sexual contact with an already-infected partner, 76 were infected by mother-to-child transmission, and 2 were transfusion related. We found env HIV-1 subtype B in 202 cases (91.4%) and subtype F in 19 cases (8.6%). Subtype B strains were found throughout the country whereas subtype F viruses were predominantly found in cases from the metropolitan/ ...
Tópico(s): HIV/AIDS Research and Interventions
2005 - Mary Ann Liebert, Inc. | AIDS Research and Human Retroviruses
María C. Brañes, Bernardo Morales, Mariana Ríos, Manuel Villalón,
The volume of oviductal fluid fluctuates during the estrous cycle, suggesting that water availability is under hormonal control. It has been postulated that sex-steroid hormones may regulate aquaporin (AQP) channels involved in water movement across cell membranes. Using a functional assay (oocytes of Xenopus laevis), we demonstrated that the rat oviductal epithelium contains mRNAs coding for water channels, and we identified by RT-PCR the mRNAs for AQP5, -8, and -9, but not for AQP2 and -3. The immunoreactivity ...
Tópico(s): Magnesium in Health and Disease
2005 - American Physical Society | AJP Cell Physiology
Pedro A. Orihuela, Mariana Ríos, Horacio B. Croxatto,
Previously, we found that the dose of estradiol (E2) required to accelerate egg transport increases 5- to 10-fold, in mated compared to cyclic rats. Here we examined protein synthesis in the oviduct of mated and cyclic rats following a single injection of E2 known to accelerate oviductal egg transport or after concomitant treatment with progesterone (P4) known to block this acceleration. On Day 1 of the cycle or pregnancy, E2, P4, or E2 + P4 were injected s.c., and 4 h later oviducts were removed and ...
Tópico(s): Ovarian function and disorders
2001 - Oxford University Press | Biology of Reproduction
Jorge Luis Torres-Fuentes, Mariana Ríos, Ricardo D. Moreno,
The acrosome reaction (AR) is the exocytosis of the acrosomal vesicle in response to different physiological and non‐physiological stimuli. Particularly in mammals, the AR is needed for sperm to fuse with the oocyte plasma membrane, and it occurs only in capacitated sperm. Previous evidence in the literature indicates that extracellular ATP induces the AR in capacitated human and bovine spermatozoa, but its receptor has not yet been identified. The aim of this work was to define a putative ATP receptor ...
Tópico(s): Adenosine and Purinergic Signaling
2015 - Wiley | Journal of Cellular Physiology
Enrico Di Minin, Álvaro Soutullo, Lucía Bartesaghi, Mariana Ríos, María Nube Szephegyi, Atte Moilanen,
Gaps in research exist for country-wide analyses to identify areas of particular importance for biodiversity and ecosystem services to help reach Aichi Target 11 in developing countries. Here we provide a spatial conservation prioritization approach that ranks landowners for maximizing the representation of biodiversity features and ecosystem services, while exploring the trade-offs with agricultural and commercial forestry production and land cost, using Uruguay as a case study. Specifically, we ...
Tópico(s): Economic and Environmental Valuation
2016 - Elsevier BV | Biological Conservation
Karla Droguett, Mariana Ríos, Daniela V. Carreño, Camilo Navarrete, Christian Fuentes, Manuel Villalón, Nelson P. Barrera,
Key points Extracellular ATP, in association with [Ca 2+ ] i regulation, is required to maintain basal ciliary beat frequency. Increasing extracellular ATP levels increases ciliary beating in airway epithelial cells, maintaining a sustained response by inducing the release of additional ATP. Extracellular ATP levels in the millimolar range, previously associated with pathophysiological conditions of the airway epithelium, produce a transient arrest of ciliary activity. The regulation of ciliary beat ...
Tópico(s): Connexins and lens biology
2017 - Wiley | The Journal of Physiology
Produção Nacional
Revisado por pares
Dóris Catharine Cornelie Knatz Kowaltowski, Elisa Atália Daniel Muianga, Ariovaldo Denis Granja, Daniel de Carvalho Moreira, Sidney Piochi Bernardini, Mariana Rios Castro,
A recent expansion of mass-housing programmes has occurred in emerging economies. The analysis of research on programmes raises questions about what type of research is produced and what its impact is on housing. The Brazilian 'My House, My Life' (Minha Casa, Minha Vida – MCMV) programme demonstrates that more of the same type of housing is produced and that the focus of most research repeats the same mistakes. Three million homes have been built and the research community has examined the programme' ...
Tópico(s): Urban Planning and Governance
2018 - Taylor & Francis | Building Research & Information
Karen Böhmwald, Nicolás M. S. Gálvez, Mariana Ríos, Alexis M. Kalergis,
Central Nervous System (CNS) infections are one of the most critical problems in public health, as frequently patients exhibit neurologic sequelae. Usually, CNS pathologies are caused by known neurotropic viruses such as measles virus, herpes virus and human immunodeficiency virus, among others. However, nowadays respiratory viruses have placed themselves as relevant agents responsible for CNS pathologies. Among these neuropathological viruses are the human respiratory syncytial virus (hRSV), the ...
Tópico(s): Influenza Virus Research Studies
2018 - Frontiers Media | Frontiers in Cellular Neuroscience
Samanta C. Funes, Mariana Ríos, Jorge Escobar‐Vera, Alexis M. Kalergis,
Macrophages are extremely heterogeneous and plastic cells with an important role not only in physiological conditions, but also during inflammation (both for initiation and resolution). In the early 1990s, two different phenotypes of macrophages were described: one of them called classically activated (or inflammatory) macrophages (M1) and the other alternatively activated (or wound-healing) macrophages (M2). Currently, it is known that functional polarization of macrophages into only two groups is an ...
Tópico(s): Immune Response and Inflammation
2018 - Wiley | Immunology
Samanta C. Funes, Mariana Ríos, Felipe Gómez‐Santander, Ayleen Fernández‐Fierro, María J. Altamirano‐Lagos, Daniela Rivera-Pérez, Raul Pulgar‐Sepúlveda, Evelyn Jara, Diego Rebolledo‐Zelada, Alejandra Villarroel, Juan Carlos Roa, Juan Pablo Mackern‐Oberti, Alexis M. Kalergis,
Summary Current treatments for systemic autoimmune diseases partially improve the health of patients displaying low pharmacological efficacy and systemic immunosuppression. Here, the therapeutic potential of transferring tolerogenic dendritic cells (tolDCs) generated with heme‐oxygenase inductor cobalt (III) protoporphyrin IX (CoPP), dexamethasone and rosiglitazone for the treatment of systemic autoimmunity was evaluated in two murine models of systemic lupus erythematosus (SLE), MRL‐Fas lpr and NZM2410 ...
Tópico(s): Immune Cell Function and Interaction
2019 - Wiley | Immunology
Karen Böhmwald, Jorge A. Soto, Catalina A. Andrade, Ayleen Fernández‐Fierro, Janyra A. Espinoza, Mariana Ríos, Eliseo A. Eugenín, Pablo A. González, María Cecilia Opazo, Claudia A. Riedel, Alexis M. Kalergis,
The human respiratory syncytial virus (hRSV) is the most common infectious agent that affects children before two years of age. hRSV outbreaks cause a significant increase in hospitalizations during the winter season associated with bronchiolitis and pneumonia. Recently, neurologic alterations have been associated with hRSV infection in children, which include seizures, central apnea, and encephalopathy. Also, hRSV RNA has been detected in cerebrospinal fluids (CSF) from patients with neurological ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2020 - Elsevier BV | Brain Behavior and Immunity
Samanta C. Funes, Mariana Ríos, Ayleen Fernández‐Fierro, Camila Covián, Susan M. Bueno, Claudia A. Riedel, Juan Pablo Mackern‐Oberti, Alexis M. Kalergis,
Heme-oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. ...
Tópico(s): Climate Change and Health Impacts
2020 - Frontiers Media | Frontiers in Immunology
Ayleen Fernández‐Fierro, Samanta C. Funes, Mariana Ríos, Camila Covián, Jorge González, Alexis M. Kalergis,
The heme oxygenase (HO) system involves three isoforms of this enzyme, HO-1, HO-2, and HO-3. The three of them display the same catalytic activity, oxidating the heme group to produce biliverdin, ferrous iron, and carbon monoxide (CO). HO-1 is the isoform most widely studied in proinflammatory diseases because treatments that overexpress this enzyme promote the generation of anti-inflammatory products. However, neonatal jaundice (hyperbilirubinemia) derived from HO overexpression led to the development ...
Tópico(s): Hemoglobin structure and function
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Álvaro Soutullo, Mariana Ríos, Natalia Zaldúa, Franco Teixeira de Mello,
Summary Soybean has undergone the greatest expansion of any global crop, fuelled by the emergence of herbicide-resistant crops. In Uruguay, soybean croplands have increased from virtually zero to more than 1 million ha in 20 years. Uruguay is also implementing its system of protected areas. Here, we assess the presence of pesticides within a Ramsar site and protected area, in a basin dominated by croplands. We consider pesticides as surrogates of the subtle impacts of agribusiness on conservation ...
Tópico(s): Agricultural Innovations and Practices
2020 - Cambridge University Press | Environmental Conservation
Felipe Melo-González, Jorge A. Soto, Liliana A González, Jorge Onrubia Fernández, Luisa F. Duarte, Bárbara M. Schultz, Nicolás M. S. Gálvez, Gaspar A. Pacheco, Mariana Ríos, Yaneisi Vázquez, Daniela Rivera-Pérez, Daniela Moreno-Tapia, Carolina Iturriaga, Omar P. Vallejos, Roslye V. Berríos-Rojas, Guillermo Hoppe-Elsholz, Marcela Urzúa, Nicole Bruneau, Rodrigo Fasce, Judith Mora, Alba Grifoni, Alessandro Sette, Daniela Weiskopf, Gang Zeng, Weining Meng, José Vicente González-Aramúndiz, Pablo A. González, Katia Abarca, Eugenio Ramı́rez, Alexis M. Kalergis, Susan M. Bueno,
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible of the current pandemic ongoing all around the world. Since its discovery in 2019, several circulating variants have emerged and some of them are associated with increased infections and death rate. Despite the genetic differences among these variants, vaccines approved for human use have shown a good immunogenic and protective response against them. In Chile, over 70% of the vaccinated population is ...
Tópico(s): Vaccine Coverage and Hesitancy
2021 - Frontiers Media | Frontiers in Immunology
Luisa F. Duarte, Nicolás M. S. Gálvez, Carolina Iturriaga, Felipe Melo-González, Jorge A. Soto, Bárbara M. Schultz, Marcela Urzúa, Liliana A González, Yaneisi Vázquez, Mariana Ríos, Roslye V. Berríos-Rojas, Daniela Rivera-Pérez, Daniela Moreno-Tapia, Gaspar A. Pacheco, Omar P. Vallejos, Guillermo Hoppe-Elsholz, María S Navarrete, Álvaro Rojas, Rodrigo Fasce, Jorge Fernández, Judith Mora, Eugenio Ramı́rez, Gang Zeng, Weining Meng, José Vicente González-Aramúndiz, Pablo A. González, Katia Abarca, Susan M. Bueno, Alexis M. Kalergis,
Constant efforts to prevent infections by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are actively carried out around the world. Several vaccines are currently approved for emergency use in the population, while ongoing studies continue to provide information on their safety and effectiveness. CoronaVac is an inactivated SARS-CoV-2 vaccine with a good safety and immunogenicity profile as seen in phase 1, 2, and 3 clinical trials around the world, with an effectiveness of 65.9% for ...
Tópico(s): Vaccine Coverage and Hesitancy
2021 - Frontiers Media | Frontiers in Immunology
Susan M. Bueno, Katia Abarca, Pablo A. González, Nicolás M. S. Gálvez, Jorge A. Soto, Luisa F. Duarte, Bárbara M. Schultz, Gaspar A. Pacheco, Liliana A González, Yaneisi Vázquez, Mariana Ríos, Felipe Melo-González, Daniela Rivera-Pérez, Carolina Iturriaga, Marcela Urzúa, Angélica Domínguez, Catalina A. Andrade, Roslye V. Berríos-Rojas, Gisela Canedo-Marroquín, Camila Covián, Daniela Moreno-Tapia, Farides Saavedra, Omar P. Vallejos, Paulina Donato, Pilar Espinoza, Daniela Fuentes, Marcela González, Paula Guzmán, Paula Muñoz Venturelli, Carlos M. Pérez, Marcela Potı́n, Álvaro Rojas, Rodrigo Fasce, Jorge Onrubia Fernández, Judith Mora, Eugenio Ramı́rez, Aracelly Gaete-Argel, Aarón Oyarzún-Arrau, Fernando Valiente‐Echeverría, Ricardo Soto‐Rifo, Daniela Weiskopf, Alessandro Sette, Gang Zeng, Weining Meng, José Vicente González-Aramúndiz, Alexis M. Kalergis,
The development of effective vaccines against coronavirus disease 2019 is a global priority. CoronaVac is an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine with promising safety and immunogenicity profiles. This article reports safety and immunogenicity results obtained for healthy Chilean adults aged ≥18 years in a phase 3 clinical trial.Volunteers randomly received 2 doses of CoronaVac or placebo, separated by 2 weeks. A total of 434 volunteers were enrolled, 397 ...
Tópico(s): Vaccine Coverage and Hesitancy
2021 - Oxford University Press | Clinical Infectious Diseases
Camila Covián, Mariana Ríos, Roslye V. Berríos-Rojas, Susan M. Bueno, Alexis M. Kalergis,
Vaccines represent an important strategy to protect humans against a wide variety of pathogens and have even led to eradicating some diseases. Although every vaccine is developed to induce specific protection for a particular pathogen, some vaccine formulations can also promote trained immunity, which is a non-specific memory-like feature developed by the innate immune system. It is thought that trained immunity can protect against a wide variety of pathogens other than those contained in the vaccine ...
Tópico(s): Viral Infections and Outbreaks Research
2021 - Frontiers Media | Frontiers in Immunology
Bárbara M. Schultz, Felipe Melo-González, Luisa F. Duarte, Nicolás M. S. Gálvez, Gaspar A. Pacheco, Jorge A. Soto, Roslye V. Berríos-Rojas, Liliana A González, Daniela Moreno-Tapia, Daniela Rivera-Pérez, Mariana Ríos, Yaneisi Vázquez, Guillermo Hoppe-Elsholz, Catalina A. Andrade, Omar P. Vallejos, Alejandro Piña-Iturbe, Carolina Iturriaga, Marcela Urzúa, María S Navarrete, Álvaro Rojas, Rodrigo Fasce, Jorge Onrubia Fernández, Judith Mora, Eugenio Ramı́rez, Aracelly Gaete-Argel, Mónica L. Acevedo, Fernando Valiente‐Echeverría, Ricardo Soto‐Rifo, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Gang Zeng, Weining Meng, José Vicente González-Aramúndiz, Pablo A. González, Katia Abarca, Alexis M. Kalergis, Susan M. Bueno,
CoronaVac is an inactivated SARS-CoV-2 vaccine approved by the World Health Organization (WHO). Previous studies reported increased levels of neutralizing antibodies and specific T cells 2 and 4 weeks after two doses of CoronaVac; these levels were significantly reduced at 6 to 8 months after the two doses. Here, we report the effect of a booster dose of CoronaVac on the anti-SARS-CoV-2 immune response generated against the variants of concern (VOCs), Delta and Omicron, in adults participating in ...
Tópico(s): Vaccine Coverage and Hesitancy
2022 - American Society for Microbiology | mBio
Samanta C. Funes, Mariana Ríos, Ayleen Fernández‐Fierro, María Silvia Di Genaro, Alexis M. Kalergis,
A dysregulated immune response toward self-antigens characterizes autoimmune and autoinflammatory (AIF) disorders. Autoantibodies or autoreactive T cells contribute to autoimmune diseases, while autoinflammation results from a hyper-functional innate immune system. Aside from their differences, many studies suggest that monocytes and macrophages (Mo/Ma) significantly contribute to the development of both types of disease. Mo/Ma are innate immune cells that promote an immune-modulatory, pro-inflammatory, ...
Tópico(s): Immune cells in cancer
2022 - Frontiers Media | Frontiers in Immunology
Jorge A. Soto, Felipe Melo-González, Cristián Gutiérrez-Vera, Bárbara M. Schultz, Roslye V. Berríos-Rojas, Daniela Rivera-Pérez, Alejandro Piña-Iturbe, Guillermo Hoppe-Elsholz, Luisa F. Duarte, Yaneisi Vázquez, Daniela Moreno-Tapia, Mariana Ríos, Pablo A Palacios, Richard García-Betancourt, Álvaro Santibáñez, Gaspar A. Pacheco, Constanza Méndez, Catalina A. Andrade, Pedro H. Silva, Benjamín Diethelm‐Varela, Patricio Astudillo, Mario Calvo, Antonio Cárdenas, Marcela González, Macarena Goldsack, Valentina Gutiérrez, Marcela Potı́n, Andrea Schilling, Lorena Tapia, Loreto Twele, Rodolfo Villena, Alba Grifoni, Alessandro Sette, Daniela Weiskopf, Rodrigo Fasce, Jorge Onrubia Fernández, Judith Mora, Eugenio Ramı́rez, Aracelly Gaete-Argel, Mónica L. Acevedo, Fernando Valiente‐Echeverría, Ricardo Soto‐Rifo, Angello Retamal‐Díaz, Nathalia Muñoz-Jofré, Xing Meng, Qianqian Xin, Eduardo Alarcón‐Bustamante, José Vicente González-Aramúndiz, Nicole Le Corre, María Javiera Álvarez-Figueroa, Pablo A. González, Katia Abarca, Cecilia Perret, Leandro J. Carreño, Susan M. Bueno, Alexis M. Kalergis, Patricio Astudillo, Epifanía Hernández Jara, Héctor Morán Fernández, Javiera Arenas Urra, Stephani Ascui Baeza, María Olivia Cabrera, José Romero Muñoz, Gonzalo Alarcón Andrade, Rocío Rodríguez Espósito, Anwar Gutiérrez Silva, Fernanda Pérez Gutiérrez, Alma Muñoz, Marcela Potin Santander, S.Mezquita Lopez, Tania Weil, Macarena Goldsack, Deidyland Arenas, Andrea Araya, Javiera Moore, Lorena Pilicita, Vania Valenzuela, Catalina Campos, Mauricio Soto, Andrea Schilling, Alberto Trautmann, Ana Fritis, Daniela Pavez, Javiera Arancibia, Lilian Rubio, Paula Viviani, Vinka Basic, Cassandra Cárcamo, Mario Calvo Gil, M. Wenzel, Nicole Carey, Roberto Aretxaga Burgos, Loreto Twele, Daniel Beltrán, Silvana Grandón, Carlos Tovar, Marcela González, Daniela Fuentes, Teresa Ramírez, Mariela Corrales, Nataly Martínez López, Valentina Gutiérrez, Felipe Reyes, Armando Lavayen, Melissa L. González, Monserrat Gutiérrez, Noris Rengifo, Carla Ortega, Florencia Saver, Lorena Tapia, Mirta Acuña, J. Carrillo de Albornoz, Tania Cariqueo, Alejandro Velásquez, Yennybeth Leiva Chamorro, Rodolfo Villena, Paola Flores, Francisca Bartsch, Belén Sepúlveda, Daniela Garmendia, Lorena González, Antonio Cárdenas, Angello Retamal, Carmen Ludeña, Carolina Hermosilla, Gustavo Keilhold, Francisco Cammarata‐Scalisi, Jessica Capón Álvarez, Jessica Romero, Pía Villarroel, Francisca Muñoz, Jorge Maya, Andrés Canales, Margarita K. Lay, Christian Muñoz, Roylester Araya,
Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been evaluated in clinical trials. However, trials addressing the immune response in the pediatric population are scarce. The inactivated vaccine CoronaVac has been shown to be safe and immunogenic in a phase 1/2 clinical trial in a pediatric cohort in China. Here, we report interim safety and immunogenicity results of a phase 3 clinical trial for CoronaVac in healthy children and adolescents in Chile. Participants ...
Tópico(s): Viral gastroenteritis research and epidemiology
2022 - American Society for Microbiology | mBio
María Elvira Balcells, Nicole Le Corre, Josefina Durán, María Elena Ceballos, Cecilia Vizcaya, Sebastián Mondaca, Martín Dib, Ricardo Rabagliati, Mauricio Sarmiento, Paula I. Burgos, Manuel Espinoza, Marcela Ferrés, Constanza Martínez-Valdebenito, Cinthya Ruiz-Tagle, Catalina Ortiz, Patricio Ross, Sigall Budnik, Sandra Solari, María de los Ángeles Vizcaya, Hanns Lembach, Roslye V. Berríos-Rojas, Felipe Melo-González, Mariana Ríos, Alexis M. Kalergis, Susan M. Bueno, Bruno Nervi,
Abstract Background Inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been widely implemented in low- and middle-income countries. However, immunogenicity in immunocompromised patients has not been established. Herein, we aimed to evaluate immune response to CoronaVac vaccine in these patients. Methods This prospective cohort study included 193 participants with 5 different immunocompromising conditions and 67 controls, receiving 2 doses of CoronaVac 8–12 weeks ...
Tópico(s): Vaccine Coverage and Hesitancy
2022 - Oxford University Press | Clinical Infectious Diseases
Pedro A. Orihuela, Lidia M. Zúñiga, Mariana Ríos, Alexis Parada‐Bustamante, Walter Sierralta, Luís Velásquez, Horacio B. Croxatto,
Mating changes the mode of action of 17beta-estradiol (E2) to accelerate oviductal egg transport from a nongenomic to a genomic mode, although in both pathways estrogen receptors (ER) are required. This change was designated as intracellular path shifting (IPS). Herein, we examined the subcellular distribution of ESR1 and ESR2 (formerly known as ER-alpha and ER-beta) in oviductal epithelial cells of rats on day 1 of cycle (C1) or pregnancy (P1) using immunoelectron microscopy for ESR1 and ESR2. The effect ...
Tópico(s): Reproductive System and Pregnancy
2009 - BioMed Central | Reproductive Biology and Endocrinology
Alexis Parada‐Bustamante, Pedro A. Orihuela, Mariana Ríos, Catherina A. Cuevas, María L. Oróstica, Luís Velásquez, Manuel Villalón, Horacio B. Croxatto,
Estradiol (E 2 ) accelerates oviductal egg transport through intraoviductal non-genomic pathways in unmated rats and through genomic pathways in mated rats. This shift in pathways has been designated as intracellular path shifting (IPS), and represents a novel and hitherto unrecognized effect of mating on the female reproductive tract. We had reported previously that IPS involves shutting down the E 2 non-genomic pathway up- and downstream of 2-methoxyestradiol. Here, we evaluated whether IPS involves ...
Tópico(s): Reproductive Biology and Fertility
2009 - Bioscientifica | Reproduction
Dóris Catharine Cornelie Knatz Kowaltowski, Ariovaldo Denis Granja, Daniel de Carvalho Moreira, Sílvia Aparecida Mikami Gonçalves Pina, Carolina Asensio Oliva, Mariana Rios Castro,
The Brazilian Federal Housing Program "Minha Casa Minha Vida" -PMCMV (My House My Life) is part of a large housing policy to eradicate the housing deficit, estimated at around five million homes in the country. The Ministry for Cities created a network of independent research organizations to evaluate the program, and the PMCMV has attracted many studies. Despite the inherent worth of these individual studies, there is a need for a holistic evaluation. A Systematic Literature Review (SLR) is seen as ...
Tópico(s): Urban and Rural Development Challenges
2015 - | Journal of the Korean housing association
Claudia González, Marisol Espinosa, María Trinidad Sánchez, Karla Droguett, Mariana Ríos, Ximena Fonseca, Manuel Villalón,
Background . Mucociliary transport (MCT) is a defense mechanism of the airway. To study the underlying mechanisms of MCT, we have both developed an experimental model of cultures, from human adenoid tissue of ciliated and secretory cells, and characterized the response to local chemical signals that control ciliary activity and the secretion of respiratory mucins in vitro . Materials and Methods . In ciliated cell cultures, ciliary beat frequency (CBF) and intracellular Ca 2+ levels were measured in response ...
Tópico(s): Tracheal and airway disorders
2013 - Hindawi Publishing Corporation | BioMed Research International
Llilian Arzola-Martínez, Rebeca Benavente, Génesis Vega, Mariana Ríos, Wendy Fonseca, Andrew J. Rasky, Susan H. Morris, Nicholas W. Lukacs, Manuel Villalón,
Allergic asthma is a chronic airway inflammatory response to different triggers like inhaled allergens. Excessive ATP in fluids from patients with asthma is considered an inflammatory signal and an important autocrine/paracrine modulator of airway physiology. Here, we investigated the deleterious effect of increased extracellular ATP (eATP) concentration on the mucociliary clearance (MCC) effectiveness and determined the role of ATP releasing channels during airway inflammation in an ovalbumin (OVA)- ...
Tópico(s): Vagus Nerve Stimulation Research
2021 - American Physical Society | AJP Lung Cellular and Molecular Physiology
Victoria I. Weisz, Mariana Ríos, Pablo Argibay,
... from a behavioral test in ratsVictoria I. Weisz, Mariana B. Rios, and Pablo F. ArgibayVictoria I. WeiszUnit of Cognitive Science, Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Potosí 450, C1199ACL, Buenos Aires, Argentina, Mariana B. RiosUnit of Cognitive Science, Instituto de Ciencias ...
Tópico(s): Neuroendocrine regulation and behavior
2012 - Imperial College Press | Journal of Integrative Neuroscience