John Huxley, Barbara Hall, Marjorie Orr, Toby Moore Agriculture Correspondent, Victoria Glendinning, Will Ellsworth-Jones, Miriam Bona, Jean Rafferty, Richard Brooks Communications Correspondent, Jon Swain, Anne Spackman, Chris Ryder, Rob Hughes, John Peter, George Jones Political Correspondent, Chris Tighe, Mrs Thatcher, Patrick Bishop, Peter Harland, Graham Rose, Cei Owen, Robert Key, Diana Wright Personal Finance Editor, Mark Lawson, Jonathan Seybold, Councillor David Williams, Stephen Milligan, Nick Pitt, Julian Symons, John Huxley Industrial Editor, Siemens, Henry Porter, Jason Tomas, Mark Hosenball, Laurel Brunner, Cal McCrystal, Ian Bruce Director General, Baris Panrose, Patrick Stoddart, Andrew Rutherford, Michael Grade, Caroline Holden, Iain Johnstone, Peter Godwin, Alan Price, Ivan Fallon, Deryk Brown, Veronica Horwell, Gail Kemp, John Witherow, Andrew, Dr Martin Cole, Cel Owen, Susan Crosland, Norman Harris, Anne Jacobs, David Connett, David Blundy, Christa McAuliffe, Giles Merritt, Geoff Whitten, Peter Ackroyd, Thompson twin, Brian Wilson, Des O'Sullivan, Rose Shepherd, Byron Rogers, Philip Robinson, Anita Brookner, Bernard Cafferty, Brian Moynahan, Max Hastings, Julie, Bill Kay, Nigella Lawson, Sue Smith, Philips, Rick Shearman, John Luke, Paul Driver, Sean French, Boris Schapiro, Rocky Horror, Richard Brooks, Mr Mogg, Tim Rayment, Brian Jackman, David Lister, Tavleen Singh, Nick Gilbert, Ian McKellen, Terry Wilkinson, Liz Jobey, Timothy Mo, Howard Goorney, Bryan Silcock, Simon Freeman, Stephen Pile, Malcolm Winton, Lendi, Simon Frith, Stephen Jones, Robert Elms, Henry Fell Chairman, Patrick Rowley, Kim Fletcher Labour Correspondent, David Lipsey, Dilys Powell, Chris Salewicz, Brough Scott, Paufa Youens, Norman Stone, Clive Everton, Caroline McGhie, Louise Branson, John, J Watson, Simon Winchester, Maurice Chittenden, Barrie Penrose, John Irvine, Sue Summers, Tim Blackstone, Michael Jones Political Editor, J. Blackmore, Philip Beresford, Godfrey Smith, Irwin M Stelzer, Brian Glanville, John Carey, Tim McGirk, Smith, Shimon Peres, Donald Farrow, Colin Clifford, Michael Green, Gareth Davies, Neil Collins City Editor, Winnie Mandela, Ian Williams, Robb Wilmot, Cadbury Schweppes, Peter Jenkins, Frank Allaun Vice-President, Marina Vaizey, Dorothy Wade, Dian Wright, David Black, George Jones, Nick Higham, Tony Hetherington, Neil Collins, Maggie Drummond, David Sawers, Rudyard Kipling, Kathryn Davies, Jon Connell, Leslie Geddes-Brown, Isabel Hilton, Georgina Howell,
... Women first Beyond Power: Men, Women & Morals by Marilyn French/Cape £15 pp640 Eilat Ski Freedom Francophiles ... Relative Values Claire Nielson and her daughter, Peggy Vance, both Cambridge undergraduates, talk to Lucy Pinney Holiday ...
1986 - Gale Group | Sunday Times HA GDA
Allison E. Ashley‐Koch, Laine E Elliott, Melanie E. Kail, Laura M. De Castro, Jude Jonassaint, Terry L. Jackson, Jennifer L. Price, Kenneth I. Ataga, Marc C. Levesque, J. Brice Weinberg, Eugene P. Orringer, Ann L. Collins, Jeffery M. Vance, Marilyn J. Telen,
Abstract Up to 30% of adult patients with sickle cell disease (SCD) will develop pulmonary hypertension (pHTN), a complication associated with significant morbidity and mortality. To identify genetic factors that contribute to risk for pHTN in SCD, we performed association analysis with 297 single nucleotide polymorphisms (SNPs) in 49 candidate genes in patients with sickle cell anemia (Hb SS) who had been screened for pHTN by echocardiography (n = 111). Evidence of association was primarily identified ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2008 - Elsevier BV | Blood
Rosemary Righter, Alex Finer, J R Halliwell Director, James Margach, John Fryer, Simon Blakey, Jon Swain, Harold Hobson, Philip Norman, Chris Ryder, Rob Hughes, Edmund Crispin, John Lambert, J G McIntyre, Paul Jennings, Berry Ritchie, Graham Rose, Antony Terry, Leonard Schapiro, Julian Symons, Jason Tomas, George Bruce, Henry Brandon, John Russell, Brian James, Andrew Robertson, Deryk Brown, Keith Botsford, Derek Jewell, Phnom Penh, Vivian Jenkins, (Mrs) Linda Lubin, Peter Watson, Norman Harris, Sue Read, Geoff Whitten, Michael Jones, Bill Glenton, (Mrs) G. M. Mitchell, Robin Marlar, Stella Fitzsimons, Cyril Connolly, Peter Wilsher Editor of Business News, Roger Eglin, Peter Lennon, Michael Howard, Raymond Mortimer, Boris Schapiro, David Holden, Maxwell Boyd, Tony Geraghty, Philip Magnus, Anthony Storr, John Hopkins, (Mrs) M J Thomas, Geoffrey Dean, Bryan Sllcock, (Mrs) D J Pomfret, Robert Lacey, Eric Marsden, J. C. Wright, Bryan Silcock, Rory Brown, Patricia Connor, Eric Jacobs, Roger Mortimer, Malcolm Winton, Edward Bond, Fred Lee Mp, Ted Clark, D. A. Trigwell, John Bell, Patrick Rowley, Lanning Roper, F. H. P. Barber, Ronald Butt, Dilys Powell, Tony Rocca, Elkan Allan, (Mrs) Verina Pettigrew, Tim Brown, Dudley Doust, Ian Nairn, Carla Markham, Felix Aprahamian, (Mrs) Helen Hawton, (Mrs) Ursula d'Arch Smith, Tony Dawe, Michael Moynihan, Brian Glanville, Graham Searjeant, Anthony Holden, Peter Dunn, Michael Roberts, Peter Walker, Michael Green, C. H. O'd. Alexander, Martin Meredith, Roy Perrott, Michael Parkinson, Roman Eisenstein, (Mrs) M. Davies, Shella Kitzinger, Graham Searjeani, Len Wood, Allan Hall, Brenda Jones, Malcolm Crawford, Roland Adburgham, Logan Gourlay, Peter Ryde, Muriel Bowen,
... a song, film a film Friday Mailer's Marilyn, Borrow's Wales Saturday Yale Safe Oil men ...
1973 - Gale Group | Sunday Times HA GDA
Laine E Elliott, Allison E. Ashley‐Koch, Laura M. De Castro, Jude Jonassaint, Jennifer L. Price, Kenneth I. Ataga, Marc C. Levesque, Jason B. Weinberg, James R. Eckman, Eugene P. Orringer, Jeffery M. Vance, Marilyn J. Telen,
Summary Priapism occurs in 30–45% of male patients with sickle cell disease (SCD), but the possible influence of genetic risk factors on the incidence of priapism is not well understood. We examined genetic polymorphisms in 199 unrelated, adult (>18 years), male patients with Hb SS and Hb S β 0 ‐thalassaemia, 83 (42%) of whom reported a history of priapism. Candidate genes for association with priapism were identified based on their involvement in adhesion, coagulation, inflammation and cell signalling. ...
Tópico(s): Genital Health and Disease
2007 - Wiley | British Journal of Haematology
Jeremy Kingston's assessment of theatre showing, D. E. A. Luxton, Anatol Lieven, Kevin Eason and Nicholas Wood, Sam Kiley Africa Correspondent, M. Rawlence, Richard Ford, Home Correspondent, Ronald Faux, Dawn Smith, Philip Howard, Elizabeth Tonge, Matthew D'Ancona, Hilary Finch, K. D. Robinson, Ian Murray, Michael Binyon, Norman De Mesquita, James Bone, C. E. Bazlinton, Carol Leonard, Robert Sheldon (Chairman, Public Accounts Committee), Lynne Truss, Wolfgang Münchau, European Business Correspondent, D. Bloom, Richard Streeton, Emrhys Barrell, Stuart Jones Football Correspondent, Neil Bennett, Banking Correspondent, Tom Walker, Martin E. Simons, Colin Narbrough, World Trade Correspondent, Edward N. Addison Chairman, Ray Clancy, Jeremy Laurance, Health Services Correspondent, Ruth Gledhill, Religion Correspondent, Christopher Elliott and Angela MacKay, Ralph Blumenau, Nicholas Wood Political Correspondent, Peter Ball, Alison Roberts, Arts Reporter, Michael Evans and Roger Boyes, Peter Bills, Michael Evans, Defence Correspondent, Jeremy Laurance Health Services Correspondent, Michael Clark, Philip Robinson, John Young, Michael Hamlyn, David Hands, Geoff Brown's assessment of films, Charles Bremner, Neil Bennett Banking Correspondent, Sarah Bagnall, John Percival, Barbara Jackson, Brian Crozier, Susan Gilchrist, Nigel L. Stockwell Managing Director, Oscar Moore, Adam Lebor, Terence Bendixson, Tim Denby, David Cowan, Robert Kirley, Robert Rhodes James, Janet Daley, Nicholas Harling, G. S. Gresty (County Trading Standards Officer), Dennis Signy, Kari Knight, David Miller, Lin Jenkins, Wolfgang Münchau, Marcus Binney, John Russell Taylor, Raymond Keene, Chess Correspondent, Craig Brown, Robert Morgan, Political Staff, Michael Clark and Philip Pangalos, Nigel Hawkes, Barry Pickthall, Keith Wheatley, David Pannick QC, Kate Alderson, K. Alsop, David Hands Rugby Correspondent, Jamie Dettmer, Adam Fresco, Roger Boyes, East Europe Correspondent, Martin Waller, Deputy City Editor, Joanna Pitman, John Goodbody, John England, James Pringle, Craig Lord, Malcolm McKeag, Richard Evans Racing Correspondent, Richard Hope, Scrivenor, David Askham, Ben MacIntyre, Richard Beeston, William Paton, Philip Pangalos, Ben Lynfield, Nigel Hawkes Science Editor, Derek Harris, Sam Kiley, Anne McElvoy, Vince Wright, Martin Waller Deputy City Editor, Alan Jackson, David Watts Diplomatic Correspondent, John Marshall, Christopher Irvine, Geoffrey Lee Williams,
... Marjorie Wallace interviewed for The Times campaign was Marilyn and Alan Lazarus and their daughter Lorraine, diagnosed ...
1993 - Gale Group | TDA
Adam C. Naj, Gyungah Jun, Christiane Reitz, Brian W. Kunkle, William Perry, Yo Son Park, Gary W. Beecham, Ruchita Rajbhandary, Kara L. Hamilton‐Nelson, Li-San Wang, John Kauwe, Matthew J. Huentelman, Amanda Myers, Thomas D. Bird, Bradley F. Boeve, Clinton T. Baldwin, Gail P. Jarvik, Paul K. Crane, Ekaterina Rogaeva, M. Michael Barmada, F. Yesim Demirci, Carlos Cruchaga, Patricia L. Kramer, Nilüfer Ertekin‐Taner, John Hardy, Neill R. Graff‐Radford, Robert C. Green, Eric B. Larson, Peter St George‐Hyslop, Joseph D. Buxbaum, Denis A. Evans, Julie A. Schneider, Kathryn L. Lunetta, M. Ilyas Kamboh, Andrew J. Saykin, Eric M. Reiman, Philip L. De Jager, David Bennett, John C. Morris, Thomas J. Montine, Alison Goate, Deborah Blacker, Debby W. Tsuang, Hákon Hákonarson, Walter A. Kukull, Tatiana Foroud, Eden R. Martin, Jonathan L. Haines, Richard Mayeux, Lindsay A. Farrer, Gerard D. Schellenberg, Margaret A. Pericak‐Vance, Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Robert W. Barber, Lisa L. Barnes, Thomas G. Beach, James T. Becker, Duane Beekly, Eileen H. Bigio, James D. Bowen, Adam Boxer, James R. Burke, Nigel J. Cairns, Laura B. Cantwell, Chuanhai Cao, Chris Carlson, Regina M. Carney, Minerva M. Carrasquillo, Steven L. Carroll, Helena C. Chui, David G. Clark, Jason J. Corneveaux, David H. Cribbs, Elizabeth Crocco, Charles DeCarli, Steven T. DeKosky, Malcolm Dick, Dennis W. Dickson, Ranjan Duara, Kelley M. Faber, Kenneth B. Fallon, Martin R. Farlow, Steven H. Ferris, Matthew P. Frosch, Douglas Galasko, Mary Ganguli, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Jonathan D. Glass, John H. Growdon, Ronald L. Hamilton, Lindy E. Harrell, Elizabeth Head, Lawrence S. Honig, Christine M. Hulette, Bradley T. Hyman, Gregory A. Jicha, Lee‐Way Jin, Anna Karydas, Jeffrey Kaye, Ronald Kim, Edward H. Koo, Neil W. Kowall, Joel H. Kramer, Frank M. LaFerla, James J. Lah, James B. Leverenz, Allan I. Levey, Ge Li, Andrew P. Lieberman, Chiao‐Feng Lin, Oscar L. López, Constantine G. Lyketsos, Wendy J. Mack, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Wayne C. McCormick, Susan M. McCurry, Andrew McDavid, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Jill R. Murrell, John Olichney, V. Shane Pankratz, Joseph E. Parisi, Henry L. Paulson, Elaine R. Peskind, Ronald Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray A. Raskind, Barry Reisberg, John M. Ringman, Erik D. Roberson, Howard J. Rosen, Roger N. Rosenberg, Mary Sano, Lon S. Schneider, William W. Seeley, Amanda Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Rudolph E. Tanzi, Tricia A. Thornton‐Wells, John Q. Trojanowski, Juan C. Troncoso, Otto Valladares, Vivianna M. Van Deerlin, Linda J. Van Eldik, Badri N. Vardarajan, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Jennifer Williamson, Sarah Wishnek, Randall L. Woltjer, Clinton B. Wright, Steven G. Younkin, Chang‐En Yu, Lei Yu,
IMPORTANCEBecause APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants.OBJECTIVES To investigate the effects of known Alzheimer disease risk loci in modifying AAO and to estimate their cumulative effect on AAO variation using data from genome-wide association studies in the Alzheimer Disease Genetics Consortium. DESIGN, SETTING, ...
Tópico(s): Epigenetics and DNA Methylation
2014 - American Medical Association | JAMA Neurology
Anthony Harris, Jon Ashworth, Nicholas Wood, Political Correspondent, Anatol Lieven, Alison Roberts Arts Reporter, Sarah Bagnall, Insurance Correspondent, Douglas McWilliams, Neil Bennett, Williams of Elvel, Graeme Crosby, Sheila Gunn, Political Correspondent, Ruth Newbury, Ross Tieman, Industrial Correspondent, Matt Wolf, Philip Howard, Ian Murray, Michael Binyon, Jeremy Kingston, Clive Davis, Lynne Truss, Carl Mortished, Kevin Eason, Geoff Brown, Bernard Levin, Aubrey Wilson, Jeremy Laurance, Health Services Correspondent, Martin Fletcher, Michael Dynes Whitehall Correspondent, Sally Rich, Alan Lee Williams (Director), Gerard Quinn, Patricia Tehan, Peter Ball, James Bone and Michael Evans Defence Correspondent, Rodney Sturdee, Louise Taylor, Hermann Bondi (Chairman), Martin Fletcher and Julia Llewellyn Smith, Martin Barrow, Nigel Waterson, Richard Ford Home Correspondent, Daniel Johnson, M. Mowlem, Andrew Cunningham, Michael Hamlyn, Tim Jones and Sheila Gunn, A. J. Clark, David Hands, Charles Bremner, Woodrow Wyatt, Jeremy Laurance Social Services Correspondent, Sarah Bagnall, John Percival, Annabel Ferriman, Philip Bassett, Industrial Editor, Aileen Ballantyne, Patricia Tehan, Banking Correspondent, J. P. Griffin, Director, Susan Gilchrist, Edward Fennell, Anne Imse, John Woodcock, George Brock, Michael Theodoulou, Martin Hoyle, Lin Jenkins, Martin Fletcher and Anatol Lieven, Barry Millington, Wolfgang Münchau and Harvey Elliott, Wolfgang Münchau, Catherine Sampson, John L. Ferguson, Jonathan Prynn, Patrick A. H. Baily (Chartered accountant and registered auditor), Peter Davalle, James D. Zirin, Raymond Keene, Chess Correspondent, Michael Clark and Philip Pangalos, Richard Evans, Tim Judah and Joel Brand, Frances Gibb and David Conn and Michael Simmons, Brian Lile, Brian Beel, Michael Hornsby, Agriculture Correspondent, Kate Alderson, David Hands Rugby Correspondent, Michael Smedley (Chairman), S. Grundy, Adam Fresco, Christopher Thomas, Joanna Pitman, John Goodbody, Edward Gorman, Ireland Correspondent, Alan Copps, Ann Savours (Mrs Shirley), Nick Nuttall, Technology Correspondent, Ross Tieman Industrial Correspondent, Adrian Deevoy, Christopher Browne, Matthew Parris, Michael Hornsby, Michael Seely, Scrivenor, Peter Riddell, Ben MacIntyre, Richard Beeston, Philip Webster and Nicholas Wood, Marilyn J. Gibbon, Nadine Meisner, David Sinclair, Philip Pangalos, Stephen Pettitt, Lionel Harrod (Secretary), G. F. Wooldridge, Nigel Hawkes Science Editor, Paul Viney (Fine Art Consultant), Derek Harris, Tom Rhodes, Dr Thomas Stuttaford, Frances Gibb Legal Correspondent, Edward Gorman and Ronald Faux, Nigel Plant, Peter Strafford, Frances Gibb, Vince Wright, Robert Morgan and Jonathan Prynn, Lindsay Cook and Sara McConnell, Mike Rosewell, Rowing Correspondent, James Macnair (Chairman), Geoffrey Lee Williams,
... ready for tugh action, Bosnia should accept the Vance-Owen peace plan, laeving the Serbs isolated Sarajevo ...
1993 - Gale Group | TDA
Sirisha Peddibhotla, Mohamed M. Khalifa, Frank J. Probst, Jennifer Stein, Leslie L. Harris, Debra L. Kearney, Gail H. Vance, Marilyn J. Bull, Dorothy K. Grange, Gunter Scharer, Sue‐Hae L. Kang, Paweł Stankiewicz, Carlos A. Bacino, Sau Wai Cheung, Ankita Patel,
Abstract Structural rearrangements of chromosome 19p are rare, and their resulting phenotypic consequences are not well defined. This is the first study to report a cohort of eight patients with subtelomeric 19p13.3 microdeletions, identified using clinical chromosomal microarray analysis (CMA). The deletion sizes ranged from 0.1 to 0.86 Mb. Detailed analysis of the patients' clinical features has enabled us to define a constellation of clinical abnormalities that include growth delay, multiple congenital ...
Tópico(s): Chromatin Remodeling and Cancer
2013 - Wiley | American Journal of Medical Genetics Part A
Holly N. Cukier, Brian W. Kunkle, Badri N. Vardarajan, Sophie Rolati, Kara L. Hamilton‐Nelson, Martin Kohli, Patrice L. Whitehead, Beth A. Dombroski, Derek Van Booven, Rosalyn Lang, Derek M. Dykxhoorn, Lindsay A. Farrer, Michael L. Cuccaro, Jeffery M. Vance, John R. Gilbert, Gary W. Beecham, Eden R. Martin, Regina M. Carney, Richard Mayeux, Gerard D. Schellenberg, Goldie S. Byrd, Jonathan L. Haines, Margaret A. Pericak‐Vance, Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig Atwood, Clinton T. Baldwin, M. Michael Barmada, Lisa L. Barnes, Sandra Barral, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, David A. Bennett, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, Adam Boxer, James R. Burke, Jeffrey M. Burns, Joseph D. Buxbaum, Goldie S. Byrd, Guiqing Cai, Nigel J. Cairns, Laura B. Cantwell, Chuanhai Cao, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Steven L. Carroll, Helena C. Chui, David G. Clark, David H. Cribbs, Elizabeth Crocco, Carlos Cruchaga, Philip L. De Jager, Charles DeCarli, F. Yesim Demirci, Malcolm Dick, Dennis W. Dickson, Ranjan Duara, Nilüfer Ertekin‐Taner, Denis A. Evans, Kelley Faber, M. Daniele Fallin, Kenneth B. Fallon, David W. Fardo, Martin R. Farlow, Lindsay A. Farrer, Steven H. Ferris, Tatiana Foroud, Matthew P. Frosch, Douglas Galasko, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Rodney C.P. Go, Alison Goate, Neill R. Graff‐Radford, Robert C. Green, Patrick Griffith, John H. Growdon, Jonathan L. Haines, Hákon Hákonarson, Ronald L. Hamilton, Kara L. Hamilton‐Nelson, Vahram Haroutunian, Lindy E. Harrell, Lawrence S. Honig, Ryan Huebinger, Christine M. Hulette, Bradley T. Hyman, Gregory A. Jicha, Lee‐Way Jin, Gyungah Jun, M. Ilyas Kamboh, Anna Karydas, John S. K. Kauwe, Jeffrey Kaye, Ronald Kim, Neil W. Kowall, Joel H. Kramer, Walter A. Kukull, Brian W. Kunkle, Frank M. LaFerla, James J. Lah, Rosalyn Lang-Walker, Eric B. Larson, James B. Leverenz, Allan I. Levey, Li Ge, Andrew P. Lieberman, Mark W. Logue, Oscar L. López, Kathryn L. Lunetta, Constantine G. Lyketsos, Wendy J. Mack, Jennifer J. Manly, Daniel Marson, Eden R. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Richard Mayeux, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, John C. Morris, Jill R. Murrell, Adam C. Naj, Thomas O. Obisesan, John Olichney, V. Shane Pankratz, Joseph E. Parisi, Amanda Partch, Henry L. Paulson, Margaret A. Pericak‐Vance, William Perry, Elaine R. Peskind, Ronald Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Towfique Raj, Murray A. Raskind, Eric M. Reiman, Barry Reisberg, Christiane Reitz, John M. Ringman, Erik D. Roberson, Howard J. Rosen, Roger N. Rosenberg, Mark A. Sager, Mary Sano, Andrew J. Saykin, Gerard D. Schellenberg, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Russell H. Swerdlow, Rudolph E. Tanzi, Tricia A. Thornton‐Wells, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Otto Valladares, Vivianna M. Van Deerlin, Linda J. Van Eldik, Badri N. Vardarajan, Harry V. Vinters, Jean Paul Vonsattel, Li‐San Wang, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Jennifer Williamson, Thomas S. Wingo, Sarah Wishnek, Randall L. Woltjer, Clinton B. Wright, Steven G. Younkin, Chang‐En Yu, Lei Yu,
Objective: To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) in the ATP-binding cassette, subfamily A ( ABC1 ), member 7 ( ABCA7 ) gene, a known risk factor for late-onset AD. Methods: Custom capture sequencing was performed on ∼150 kb encompassing ABCA7 in 40 AA cases and 37 AA controls carrying the AA risk allele (rs115550680). Association testing was performed for an ABCA7 deletion identified in large AA data sets (discovery n = 1,068; replication n = 1,749) and whole ...
Tópico(s): MicroRNA in disease regulation
2016 - Wolters Kluwer | Neurology Genetics
Patricia G. Wheeler, David D. Weaver, Mercy O. Obeime, Gail H. Vance, Marilyn J. Bull, Luis Escobar,
We present the findings of 13 additional cases of the urorectal septum malformation (URSM) sequence, and review the literature. The URSM sequence consists of ambiguous genitalia concurrent with absence of perineal and anal openings. The sex ratio of the 13 new cases was 7 males to 6 females and from the literature 21 males and 28 females. In addition, 11 of the 13 new cases had anorectal atresia with 5 of the cases also having partial agenesis of the colon. Bilateral renal agenesis was present in ...
Tópico(s): Pediatric Urology and Nephrology Studies
1997 - Wiley | American Journal of Medical Genetics
Allison E. Ashley‐Koch, Laura M. De Castro, Felicia Lennon‐Graham, Jude Jonassaint, Terry L. Jackson, Jennifer L. Price, Jason Galloway, Susan Jones, Eldrida Randall, Charles H. Packman, Charles Knupp, James R. Eckman, Eugene P. Orringer, Jeffery M. Vance, Marilyn J. Telen,
Abstract The life expectancy of many patients with sickle cell disease (SCD) is well into the 5th and 6th decade, but this remains extremely variable. Little is known about the biological factors that protect certain SCD patients from early demise while others never reach mid-adulthood. Recently, McKerrell and colleagues (2004) compared the clinical and laboratory profiles of SCD patients aged 40 years and over with SCD patients who were between 21 and 30 years of age. Similarly, we have compared ...
Tópico(s): Iron Metabolism and Disorders
2005 - Elsevier BV | Blood
Allison E. Ashley‐Koch, Laura M. De Castro, Felicia Lennon‐Graham, Jude Jonassaint, Terry L. Jackson, Jennifer L. Price, Jason Galloway, Ken I. Ataga, Eugene P. Orringer, Jeffery M. Vance, Marilyn J. Telen,
Tópico(s): Hemoglobinopathies and Related Disorders
2004 - Elsevier BV | Blood
Sara E. Cosgrove, Gloria Vigliani, Marilyn Campion, Vance G. Fowler, Elías Abrutyn, G. Ralph Corey, Donald P. Levine, Mark E. Rupp, Henry F. Chambers, Adolf W. Karchmer, Helen W. Boucher,
The safety of adding initial low-dose gentamicin to antistaphylococcal penicillins or vancomycin for treatment of suspected Staphylococcus aureus native valve endocarditis is unknown. This study evaluated the association between this practice and nephrotoxicity.We performed a prospective cohort study of safety data from a randomized, controlled trial of therapy for S. aureus bacteremia and native valve infective endocarditis involving 236 patients from 44 hospitals in 4 countries. Patients either ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2009 - Oxford University Press | Clinical Infectious Diseases
Alasdair Vance, Katrina Harris, Marilyn Boots, Jessica Talbot, Mary Karamitsios,
Attention deficit hyperactivity disorder, combined type (ADHD-CT), dysthymic disorder, and anxiety disorders frequently co-occur in primary school age children, although there have been no published data describing their association. We investigated the association of anxiety, defined from a parent or child perspective, with primary school-age children with ADHD-CT with and without dysthymic disorder.One hundred and forty-six medication naïve children with ADHD-CT were studied. Two groups with and ...
Tópico(s): Cognitive Functions and Memory
2003 - SAGE Publishing | Australian & New Zealand Journal of Psychiatry
Li-San Wang, Adam C. Naj, Robert Graham, Paul K. Crane, Brian W. Kunkle, Carlos Cruchaga, Josue D. Gonzalez Murcia, Lisa Cannon‐Albright, Clinton T. Baldwin, Henrik Zetterberg, Kaj Blennow, Walter A. Kukull, Kelley M. Faber, Nicole Schupf, Maria C. Norton, JoAnn T. Tschanz, Ronald G. Munger, Christopher Corcoran, Ekaterina Rogaeva, Chiao‐Feng Lin, Beth A. Dombroski, Laura B. Cantwell, Amanda Partch, Otto Valladares, Hákon Hákonarson, Peter St George‐Hyslop, Robert C. Green, Alison Goate, Tatiana Foroud, Regina M. Carney, Eric B. Larson, Timothy W. Behrens, John Kauwe, Jonathan L. Haines, Lindsay A. Farrer, Margaret A. Pericak‐Vance, Richard Mayeux, Gerard D. Schellenberg, Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Robert W. Barber, M. Michael Barmada, Lisa L. Barnes, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, David A. Bennett, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James R. Burke, Joseph D. Buxbaum, Nigel J. Cairns, Chuanhai Cao, Chris Carlson, Steven L. Carroll, Helena C. Chui, David G. Clark, David H. Cribbs, Elizabeth Crocco, Charles DeCarli, Steven T. DeKosky, F. Yesim Demirci, Malcolm Dick, Dennis W. Dickson, Ranjan Duara, Nilüfer Ertekin‐Taner, Kenneth B. Fallon, Martin R. Farlow, Steven H. Ferris, Matthew P. Frosch, Douglas Galasko, Mary Ganguli, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Jonathan D. Glass, Neill R. Graff‐Radford, John H. Growdon, Ronald L. Hamilton, Kara L. Hamilton‐Nelson, Lindy E. Harrell, Elizabeth Head, Lawrence S. Honig, Christine M. Hulette, Bradley T. Hyman, Gail P. Jarvik, Gregory A. Jicha, Lee‐Way Jin, Gyungah Jun, M. Ilyas Kamboh, Anna Karydas, Jeffrey Kaye, Ronald Kim, Edward H. Koo, Neil W. Kowall, Joel H. Kramer, Patricia Kramer, Frank M. LaFerla, James J. Lah, James B. Leverenz, Allan I. Levey, Ge Li, Andrew P. Lieberman, Oscar L. López, Kathryn L. Lunetta, Constantine G. Lyketsos, Wendy J. Mack, Daniel Marson, Eden R. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Wayne C. McCormick, Susan M. McCurry, Andrew McDavid, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, John C. Morris, Jill R. Murrell, John Olichney, Joseph E. Parisi, William Perry, Elaine R. Peskind, Ronald Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray A. Raskind, Eric M. Reiman, Barry Reisberg, Christiane Reitz, John M. Ringman, Erik D. Roberson, Howard J. Rosen, Roger N. Rosenberg, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Rudolph E. Tanzi, Tricia A. Thornton‐Wells, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. Van Eldik, Badri N. Vardarajan, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Jennifer Williamson, Sarah Wishnek, Randall L. Woltjer, Clinton B. Wright, Steven G. Younkin, Chang‐En Yu, Lei Yu,
Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.To determine the frequency of the APP A673T ...
Tópico(s): Genetic Associations and Epidemiology
2014 - American Medical Association | JAMA Neurology
Patricia G. Wheeler, David D. Weaver, Mercy O. Obeime, Gail H. Vance, Marilyn J. Bull, Luis Escobar,
We present the findings of 13 additional cases of the urorectal septum malformation (URSM) sequence, and review the literature. The URSM sequence consists of ambiguous genitalia concurrent with absence of perineal and anal openings. The sex ratio of the 13 new cases was 7 males to 6 females and from the literature 21 males and 28 females. In addition, 11 of the 13 new cases had anorectal atresia with 5 of the cases also having partial agenesis of the colon. Bilateral renal agenesis was present in ...
Tópico(s): Pediatric Urology and Nephrology Studies
1997 - Wiley | American Journal of Medical Genetics
A. James Mamary, Jeffery I. Stewart, Gregory L. Kinney, John E. Hokanson, Kartik Shenoy, Mark T. Dransfield, Marilyn G. Foreman, Gwendolyn B. Vance, Gerard J. Criner,
The COPD Genetic Epidemiology (COPDGene®) study provides a rich cross-sectional dataset of patients with substantial tobacco smoke exposure, varied by race, gender, chronic obstructive pulmonary disease (COPD) diagnosis, and disease. We aimed to determine the influence of race, gender and Global
Tópico(s): Asthma and respiratory diseases
2018 - COPD Foundation | Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation
Allison M. Cushman‐Vokoun, Josh Lauring, John D. Pfeifer, Damon R. Olson, Anna B. Berry, John Thorson, Karl V. Voelkerding, Jonathan Myles, James M. Barbeau, Pranil Chandra, Marilyn M. Li, Gail H. Vance, Brad W. Jensen, Molly Y. Hansen, Sophia Yohe,
Context.— Next-generation sequencing is a powerful clinical tool for cancer management but can produce incidental/secondary findings that require special consideration. Objective.— To discuss clinical and laboratory issues related to incidental or secondary germline findings in the clinical setting of tumor testing and inform future guidelines in this area. Design.— A College of American Pathologists workgroup including representation from the American Society of Clinical Oncology, the Association ...
Tópico(s): Genomics and Rare Diseases
2021 - American Medical Association | Archives of Pathology & Laboratory Medicine
Tahaniyat Lalani, Jerome J. Federspiel, Helen W. Boucher, Thomas H. Rude, In‐Gyu Bae, Michael J. Rybak, Giang T. Tonthat, G. Ralph Corey, Martín E. Stryjewski, George Sakoulas, Vivian H. Chu, Jeff Alder, Judith N. Steenbergen, Steven A. Luperchio, Marilyn Campion, Christopher W. Woods, Vance G. Fowler,
We investigated associations between the genotypic and phenotypic features of Staphylococcus aureus bloodstream isolates and the clinical characteristics of bacteremic patients enrolled in a phase III trial of S. aureus bacteremia and endocarditis. Isolates underwent pulsed-field gel electrophoresis, PCR for 33 putative virulence genes, and screening for heteroresistant glycopeptide intermediate S. aureus (hGISA). A total of 230 isolates (141 methicillin-susceptible S. aureus and 89 methicillin-resistant ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2008 - American Society for Microbiology | Journal of Clinical Microbiology
Perry G. Ridge, Kaitlyn B. Hoyt, Kevin L. Boehme, Shubhabrata Mukherjee, Paul K. Crane, Jonathan L. Haines, Richard Mayeux, Lindsay A. Farrer, Margaret A. Pericak‐Vance, Gerard D. Schellenberg, John S. K. Kauwe, Perrie M. Adams, Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig Atwood, Clinton T. Baldwin, Robert C. Barber, M. Michael Barmada, Lisa L. Barnes, Sandra Barral, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, David A. Bennett, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James R. Burke, Jeffrey M. Burns, Joseph D. Buxbaum, Nigel J. Cairns, Laura B. Cantwell, Chuanhai Cao, Chris Carlson, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Steven L. Carroll, Helena C. Chui, David G. Clark, Jason J. Corneveaux, Paul K. Crane, David H. Cribbs, Elizabeth Crocco, Carlos Cruchaga, Philip L. De Jager, Charles DeCarli, F. Yesim Demirci, Malcolm Dick, Dennis W. Dickson, Rachelle S. Doody, Ranjan Duara, Nilüfer Ertekin‐Taner, Denis A. Evans, Kelley Faber, Thomas Fairchild, Kenneth B. Fallon, David W. Fardo, Martin R. Farlow, Steven H. Ferris, Tatiana M. Foroud, Matthew P. Frosch, Douglas Galasko, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Alison Goate, Neill R. Graff‐Radford, Robert C. Green, John H. Growdon, Hákon Hákonarson, Ronald L. Hamilton, Kara L. Hamilton‐Nelson, John Hardy, Lindy E. Harrell, Lawrence S. Honig, Ryan Huebinger, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Gail P. Jarvik, Gregory A. Jicha, Lee‐Way Jin, Gyungah Jun, M. Ilyas Kamboh, Anna Karydas, Mindy J. Katz, John S. K. Kauwe, Jonathan Kaye, Ronald Kim, Neil W. Kowall, Joel H. Kramer, Walter A. Kukull, Brian W. Kunkle, Frank M. LaFerla, James J. Lah, Eric B. Larson, James B. Leverenz, Allan I. Levey, Ge Li, Andrew P. Lieberman, Chiao‐Feng Lin, Richard B. Lipton, Oscar L. López, Kathryn L. Lunetta, Constantine G. Lyketsos, Wendy J. Mack, Daniel Marson, Eden R. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Wayne C. McCormick, Susan M. McCurry, Andrew McDavid, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, John C. Morris, Shubhabrata Mukherjee, Jill R. Murrell, Amanda Myers, Adam C. Naj, Sid E. O’Bryant, John Olichney, V. Shane Pankratz, Joseph E. Parisi, Amanda Partch, Henry L. Paulson, William Perry, Elaine R. Peskind, Ronald Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray A. Raskind, Eric M. Reiman, Barry Reisberg, Joan Reisch, Christiane Reitz, John M. Ringman, Erik D. Roberson, Ekaterina Rogaeva, Howard J. Rosen, Roger N. Rosenberg, Donald R. Royall, Mark A. Sager, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda Smith, Joshua A. Sonnen, Salvatore Spina, Peter St George‐Hyslop, Robert A. Stern, Russell H. Swerdlow, Rudolph E. Tanzi, Tricia A. Thornton‐Wells, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Otto Valladares, Vivianna M. Van Deerlin, Linda J. Van Eldik, Badri N. Vardarajan, Harry V. Vinters, Jean Paul Vonsattel, Li-San Wang, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Jens R. Wendland, Kirk C. Wilhelmsen, Jennifer Williamson, Thomas S. Wingo, Ashley R. Winslow, Sarah Wishnek, Randall L. Woltjer, Clinton B. Wright, Chuang‐Kuo Wu, Steven G. Younkin, Chang‐En Yu, Lei Yu,
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated with AD. Recently, several rare variants have been identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin Receptor C (UNC5C) that affect risk for AD. Despite the many successes, the genetic architecture of AD remains unsolved. We used Genome-wide Complex Trait Analysis to (1) estimate ...
Tópico(s): GDF15 and Related Biomarkers
2016 - Elsevier BV | Neurobiology of Aging
Thomas L. Ortel, Craig S. Kitchens, Doruk Erkan, Leonardo R. Brandão, Susan Hahn, Allison James, Roshni Kulkarni, Marilyn J. Manco‐Johnson, Margaret A. Pericak‐Vance, Jeffery M. Vance,
Thrombotic storm represents an extreme prothrombotic phenotype, characterized by multiple thrombotic events affecting diverse vascular beds occurring over a brief period of time. Thrombotic events involve venous and arterial circulation, including unusual locations, such as cerebral sinus venous thrombosis, intra-abdominal thromboembolic occlusions and microvascular events. Some patients will have antiphospholipid antibodies, but a significant number have no identifiable hypercoagulable state. The ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2012 - Taylor & Francis | Expert Review of Hematology
Matthew R. Sanders, Yolanda Arduca, Mary Karamitsios, Marilyn Boots, Alasdair Vance,
Internalizing and externalizing disorders are frequently comorbid with attention deficit hyperactivity disorder, combined type (ADHD-CT) and dysthymic disorder (DD) in referred primary school-age children, yet there has been relatively little systematic research of the nature of these comorbid disorders. We describe the characteristics of parent- and child-reported internalizing and externalizing disorders in primary school-age children with ADHD-CT and DD.A cross-sectional study of 45 clinically ...
Tópico(s): Bipolar Disorder and Treatment
2005 - SAGE Publishing | Australian & New Zealand Journal of Psychiatry
Marilyn N. Vera-Chang, Thomas W. Moon, Vance L. Trudeau,
Fluoxetine (FLX), the active ingredient in well-known therapeutic drugs such as Prozac, is highly prescribed worldwide to treat affective disorders even among pregnant women and adolescents. Given that FLX readily crosses the placenta, a fetus from a treated pregnant woman is potentially at risk from unintended effects of the chemical. Moreover, FLX reaches aquatic ecosystems at biologically active levels through sewage release, so fish may also be inadvertently affected. We previously demonstrated ...
Tópico(s): Reproductive biology and impacts on aquatic species
2019 - Elsevier BV | Toxicology and Applied Pharmacology
Marilyn N. Vera-Chang, Thomas W. Moon, Vance L. Trudeau,
Owing to the prevalence of depression during childbearing, mothers can be prescribed multiple antidepressants; however, little is known about the risk and consequences to the offspring or subsequent generations. Fluoxetine (FLX) is usually the first-line of pharmacological treatment for affective disorders in pregnant women, with venlafaxine (VEN) used as secondary treatment. Given that FLX and VEN readily cross the placenta, a fetus from a treated pregnant woman is potentially at risk of the endocrine ...
Tópico(s): Stress Responses and Cortisol
2019 - Oxford University Press | Endocrinology
Zeina A. Kanafani, Helen W. Boucher, Vance G. Fowler, Christopher H. Cabell, Bruno Hoen, José M. Miró, Tahaniyat Lalani, Gloria Vigliani, Marilyn Campion, Ralph Corey, Donald P. Levine,
In a recent randomized trial of Staphylococcus aureus bacteremia and native valve endocarditis, daptomycin was found not inferior to standard therapy. We summarized findings in the subgroup of patients with endocarditis according to the Duke criteria. Patients were randomly assigned to receive daptomycin 6 mg/kg/day or standard therapy (vancomycin 1 g every 12 h or antistaphylococcal penicillin 2 g every 4 h, both with gentamicin 1 mg/kg every 8 h for the first 4 days). The primary end point was ...
Tópico(s): Antifungal resistance and susceptibility
2010 - Elsevier BV | Enfermedades Infecciosas y Microbiología Clínica
C. Britt Bousman, Michael B. Collins, Paul Goldberg, Thomas W. Stafford, Jan Guy, Barry W. Baker, D. Gentry Steele, Marvin Kay, Anne C. Kerr, Glen G. Fredlund, Phil Dering, Vance T. Holliday, Diane E. Wilson, W. A. Gose, Susan Dial, Paul Takac, Robin Balinsky, Marilyn A. Masson, Joseph F. Powell,
The transition from Palaeoindian to Archaic societies in North America is often viewed as a linear progression over a brief but time-transgressive period. New evidence from the Wilson-Leonard site in Texas suggests social experimentation by Palaeoindians over a 2500-year period eventually resulted in Archaic societies. The process was neither short nor linear, and the evidence shows that different but contemporaneous lifeways existed in a variety of locales in the south-central US in the Early Holocene.
Tópico(s): Geology and Paleoclimatology Research
2002 - Cambridge University Press | Antiquity
Mahdi Ghani, Christiane Reitz, Rong Cheng, Badri N. Vardarajan, Gyungah Jun, Christine Sato, Adam C. Naj, Ruchita Rajbhandary, Li San Wang, Otto Valladares, Chiao‐Feng Lin, Eric B. Larson, Neill R. Graff‐Radford, Denis A. Evans, Philip L. De Jager, Paul K. Crane, Joseph D. Buxbaum, Jill R. Murrell, Towfique Raj, Nilüfer Ertekin‐Taner, Mark Logue, Clinton T. Baldwin, Robert C. Green, Lisa L. Barnes, Laura B. Cantwell, M. Daniele Fallin, Rodney C.P. Go, Patrick Griffith, Thomas O. Obisesan, Jennifer J. Manly, Kathryn L. Lunetta, M. Ilyas Kamboh, Oscar L. López, David A. Bennett, Hugh C. Hendrie, Kathleen Hall, Alison Goate, Goldie S. Byrd, Walter A. Kukull, Tatiana M. Foroud, Jonathan L. Haines, Lindsay A. Farrer, Margaret A. Pericak‐Vance, Joseph H. Lee, Gerard D. Schellenberg, Peter St George‐Hyslop, Richard Mayeux, Ekaterina Rogaeva, Marilyn Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Robert C. Barber, M. Michael Barmada, Thomas G. Beach, Gary W. Beecham, Duane Beekly, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James R. Burke, Guiqing Cai, Nigel J. Cairns, Chuanhai Cao, Chris Carlson, Regina M. Carney, Steven L. Carroll, Helena C. Chui, David G. Clark, David H. Cribbs, Elizabeth Crocco, Carlos Cruchaga, Charles DeCarli, Steven T. DeKosky, F. Yesim Demirci, Malcolm Dick, Kelley M. Faber, Kenneth B. Fallon, Steven H. Ferris, Matthew P. Frosch, Douglas Galasko, Mary Ganguli, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Sid Gilman, Jonathan D. Glass, John H. Growdon, Hakon Hakonarson, Ronald L. Hamilton, Kara L. Hamilton‐Nelson, Vahram Haroutunian, Lindy E. Harrell, Lawrence S. Honig, Christine M. Hulette, Bradley T. Hyman, Gail P. Jarvik, Gregory A. Jicha, Lee Way Jin, Anna Karydas, John Kauwe, Jonathan Kaye, Ronald Kim, Edward H. Koo, Neil W. Kowall, Joel H. Kramer, Patricia Kramer, Frank M. LaFerla, James J. Lah, Rosalyn Lang-Walker, James B. Leverenz, Allan I. Levey, Ge Li, Andrew P. Lieberman, Constantine G. Lyketsos, Wendy J. Mack, Daniel Marson, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Wayne C. McCormick, Susan M. McCurry, Andrew McDavid, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Kathleen S. Montine, John C. Morris, John Olichney, Joseph E. Parisi, Elaine R. Peskind, Ronald C. Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray A. Raskind, Eric M. Reiman, Barry Reisberg, John M. Ringman, Erik D. Roberson, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Rudolph E. Tanzi, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. Van Eldik, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Jennifer Williamson, Randall L. Woltjer, Clinton B. Wright, Steven G. Younkin, Chang En Yu, Lei Yu,
Importance Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nucleotide polymorphism (SNP) arrays. Objective To evaluate the association between ROHs and AD in an African American population known to have a risk for AD up to 3 times higher than white individuals. Design, Setting, and Participants ...
Tópico(s): Genomic variations and chromosomal abnormalities
2015 - American Medical Association | JAMA Neurology
Catherine G. Palmer, Jean‐Louis Blouin, Marilyn J. Bull, P P Breitfeld, Gail H. Vance, Timothy Van Meter, David D. Weaver, Nyla A. Heerema, Steve Colbern, Julie R. Korenberg, Stylianos E. Antonarakis, X. Chen,
Abstract We describe a patient with an asymmetric double ring 21 in mosaic form, 45,XX,‐21/46, XX,‐21,+r(21), who has limited manifestations of Down syndrome and who developed acute myelofibrosis and megakaryocytic leukemia (AMKL), FAB M7, a hematologic disorder particularly common in Down syndrome patients. In situ hybridization studies, gene dosage, and DNA polymorphism analysis showed that the ring chromosome carries a duplicated region which extends from D21S406 on the centromeric side and includes ...
Tópico(s): Chronic Lymphocytic Leukemia Research
1995 - Wiley | American Journal of Medical Genetics
Logan Dumitrescu, Lisa L. Barnes, Madhav Thambisetty, Gary W. Beecham, Brian W. Kunkle, William S. Bush, Katherine A. Gifford, Lori B. Chibnik, Shubhabrata Mukherjee, Philip L. De Jager, Walter A. Kukull, Paul K. Crane, Susan M. Resnick, C. Dirk Keene, Thomas J. Montine, Gerard D. Schellenberg, Yuetiva Deming, Michael J. Chao, Matt Huentelman, Eden R. Martin, Kara L. Hamilton‐Nelson, Leslie M. Shaw, John Q. Trojanowski, Elaine R. Peskind, Carlos Cruchaga, Margaret A. Pericak‐Vance, Alison Goate, Nancy J. Cox, Jonathan L. Haines, Henrik Zetterberg, Kaj Blennow, Eric B. Larson, Sterling C. Johnson, Marilyn Albert, David Bennett, Julie A. Schneider, Angela L. Jefferson, Timothy J. Hohman,
Abstract Autopsy measures of Alzheimer’s disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). However, despite evidence of sex differences in Alzheimer’s disease risk, sex-stratified models have not been incorporated into previous GWAS analyses. We looked for sex-specific genetic associations with Alzheimer’s disease endophenotypes from six brain bank data repositories. The pooled dataset included 2701 males and 3275 females, the majority ...
Tópico(s): Dementia and Cognitive Impairment Research
2019 - Oxford University Press | Brain
Katrina Harris, Marilyn Boots, Jessica Talbot, Alasdair Vance,
Tópico(s): Perfectionism, Procrastination, Anxiety Studies
2006 - Springer Science+Business Media | Child Psychiatry & Human Development