Silvia Casarotto, Leonor J. Romero Lauro, Valentina Bellina, Adenauer G. Casali, Mario Rosanova, Andrea Pigorini, Stefano Defendi, Maurizio Mariotti, Marcello Massimini,
Background High-density electroencephalography (hd-EEG) combined with transcranial magnetic stimulation (TMS) provides a direct and non-invasive measure of cortical excitability and connectivity in humans and may be employed to track over time pathological alterations, plastic changes and therapy-induced modifications in cortical circuits. However, the diagnostic/monitoring applications of this technique would be limited to the extent that TMS-evoked potentials are either stereotypical (non-sensitive) ...
Tópico(s): Advanced MRI Techniques and Applications
2010 - Public Library of Science | PLoS ONE
Marcello Massimini, Mélanie Boly, Adenauer G. Casali, Mario Rosanova, Giulio Tononi,
How do we evaluate a brain's capacity to sustain conscious experience if the subject does not manifest purposeful behaviour and does not respond to questions and commands? What should we measure in this case? An emerging idea in theoretical neuroscience is that what really matters for consciousness in the brain is not activity levels, access to sensory inputs or neural synchronization per se, but rather the ability of different areas of the thalamocortical system to interact causally with each other ...
Tópico(s): Neural dynamics and brain function
2009 - Elsevier BV | Progress in brain research
Fernando Luíz Finger, Maria Edith Della-Justina, Vicente Wagner Dias Casali, Mário Puiatti,
Little information is available on the influence of temperature on plastic films wrapped okra (Albelmoschus esculentus) for their postharvested conservation. This works investigated the influence of the temperature and PVC film on the development of chilling injury and storability from one of the most popular Brazilian cultivar of okra cv. Amarelinho in fruits stored at 5, 10ºC and at 25ºC. Fruits were harvest at commercial maturity stage with length ranging from 8 to 12 cm, and immediately wrapped ...
Tópico(s): Plant Physiology and Cultivation Studies
2008 - UNIVERSIDADE DE SÃO PAULO | Scientia Agricola
Elisabetta Pennacchioli, Marcello Deraco, Luigi Mariani, Marco Fiore, Chiara Mussi, Paola Collini, Patrizia Olmi, Paolo G. Casali, Mario Santinami, Alessandro Gronchi,
Tópico(s): Bone Tumor Diagnosis and Treatments
2006 - Springer Science+Business Media | Annals of Surgical Oncology
Francesco Santini, Gianluca Casali, Mario Lusini, Augusto D’Onofrio, Enrico Barbieri, Giorgio Rigatelli, Gianfranco Franco, Alessandro Mazzucco,
Objective: To analyze the results of extensive reconstruction of the left anterior descending coronary artery (LAD) by an autologous vein patch, with or without endarterectomy (EA), associated with left internal mammary artery grafting onto the patch. Methods: Between January 1994 and April 2001, among 5871 myocardial revascularizations, 83 patients (1.4%), 77 male (93%), with a mean age±SD of 64±8 years (range 44–84) underwent the above mentioned procedure. Seventy-three of them (88%) were in Canadian ...
Tópico(s): Coronary Interventions and Diagnostics
2002 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
Claudio Bruschi, Isa Cerveri, Maria C. Zoia, Francesco Fanfulla, Marilina Fiorentini, Lucio Casali, Mario Grassi, C Grassi,
The aim of our study was to measure values of maximal inspiratory (MIP) and expiratory (MEP) mouth pressures in 625 (266 male, 359 female) clinically and functionally normal subjects drawn out of a sample representative of the general population. MEP (near TLC and FRC) was found to be significantly higher when compared with MIP (near RV and FRC), and pressures in male subjects were significantly higher than those in female subjects. MEP values at TLC and FRC were found to be closely related, as were ...
Tópico(s): Reliability and Agreement in Measurement
1992 - American Thoracic Society | American Review of Respiratory Disease
Anna Maria Stabile, Alessandra Pistilli, Lucia Crispoltoni, Claudia Montagnoli, Roberto Tiribuzi, Lucio Casali, Mario Rende,
Nerve growth factor and its receptors, TrkA and p75NTR, are involved in inflammation and airways diseases, but their role in chronic obstructive pulmonary disease is still unclear and not well investigated. our data indicate the stage dependent variation of nerve growth factor and its receptors in chronic obstructive pulmonary disease progression. In fact, for the first time, this study evaluates the presence of nerve growth factor and its receptors in serum and in peripheral blood mononuclear cells ...
Tópico(s): Pediatric health and respiratory diseases
2015 - De Gruyter | Biological Chemistry
Produção Nacional
Revisado por pares
Adenauer G. Casali, Olivia Gosseries, Mario Rosanova, Mélanie Boly, Simone Sarasso, Karina Rabello Casali, Silvia Casarotto, Marie-Aurélie Bruno, Steven Laureys, Giulio Tononi, Marcello Massimini,
A theory-derived index of consciousness, which quantifies the complexity of the brain’s response to a stimulus, measures the level of consciousness in awake, sleeping, anesthetized, and brain-damaged subjects.
Tópico(s): Neural dynamics and brain function
2013 - American Association for the Advancement of Science | Science Translational Medicine
Produção Nacional
Revisado por pares
Simone Sarasso, Adenauer G. Casali, Silvia Casarotto, Mario Rosanova, Corrado Sinigaglia, Marcello Massimini,
Over the last years, a surge of empirical studies converged on complexity-related measures as reliable markers of consciousness across many different conditions, such as sleep, anesthesia, hallucinatory states, coma, and related disorders. Most of these measures were independently proposed by researchers endorsing disparate frameworks and employing different methods and techniques. Since this body of evidence has not been systematically reviewed and coherently organized so far, this positive trend ...
Tópico(s): Functional Brain Connectivity Studies
2021 - University of Oxford | Neuroscience of Consciousness
Claudio F. Donner, S. Amaducci, Elena Bacci, Sandra Baldacci, Maria Laura Bartoli, Gianfranco Maria Beghi, Alida Benfante, Sara Brighindi, Lucio Casali, Daniela Castiglia, Mario Cazzola, Alessandro Celi, Silvana Cianchetti, Giorgio Lorenzo Colombo, Claudia Crimi, Federico L. Dente, Giuseppe Di Maria, Annalisa Di Maria, Manuela Latorre, Federico Lavorini, Sara Maio, Claudia Mannini, Riccardo Messina, Pier Luigi Paggiaro, Patrizia Pignatti, David Price, Nicola Scichilone, Marzia Simoni, Antonio Spanevello, Martina Stagno dâ€TMAlcontres, Shawna Tan, Roberto Torchio, Giovanni Viegi, Dina Visca, Emiel F.�M. Wouters, Shaylynn Yu Hui Xin,
Proceedings of the European Seminars in Respiratory Medicine course, Inhalation therapy in the next decade: Determinants of adherence to treatment in asthma and COPD, held in Taormina, Italy, on 3-4 March, 2017
Tópico(s): Inhalation and Respiratory Drug Delivery
2018 - PAGEPress (Italy) | Monaldi Archives for Chest Disease
Martino Napolitani, Olivier Bodart, Paola Canali, Francesca Seregni, Adenauer G. Casali, Steven Laureys, Mario Rosanova, Marcello Massimini, Olivia Gosseries,
Background: This review discusses the advantages of transcranial magnetic stimulation combined with high-density electroencephalography (TMS-hdEEG) over other current techniques of brain imaging.Methods and results: Its application was reviewed, focusing particularly on disorders of consciousness, in the perspective of recent theories of consciousness. Assessment of non-communicative patients with disorders of consciousness remains a clinical challenge and objective measures of the level of consciousness ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2014 - Taylor & Francis | Brain Injury
Adenauer G. Casali, Silvia Casarotto, Mario Rosanova, Maurizio Mariotti, Marcello Massimini,
Transcranial magnetic stimulation (TMS) combined with simultaneous high-density electroencephalography (hd-EEG) represents a straightforward way to gauge cortical excitability and connectivity in humans. However, the analysis, classification and interpretation of TMS-evoked potentials are hampered by scarce a priori knowledge about the physiological effect of TMS and by lack of an established data analysis framework. Here, we implemented a standardized, data-driven procedure to characterize the electrical ...
Tópico(s): EEG and Brain-Computer Interfaces
2009 - Elsevier BV | NeuroImage
Giovanni Battista Migliori, Marco Ambrosetti, Giorgio Besozzi, L Casali, Mario Raviǵlione,
Cohort analysis of treatment outcomes is the most informative technique to evaluate the tuberculosis (TB) control programme. The aim of the study was to assess treatment outcomes comparing the smear- versus the culture-based methods, using data on TB patients treated under programme conditions in Italy. This was a prospective monitoring study based on the standardized collection of forms from a representative sample of Italian TB Units. The forms, with individual data, were reviewed and analysed ...
Tópico(s): Diagnosis and treatment of tuberculosis
1999 - European Respiratory Society | European Respiratory Journal
Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Mario Meloni, Giulio Riboldazzi, Roberta Zangaglia, Andrea Sturchio, Carlo Casali, Cherubino Di Lorenzo, Brigida Minafra, Mario Clerici,
The etiology of Parkinson's disease (PD) is presumably multifactorial and likely involves interactions between genetic and environmental factors, as well as mitochondrial dysfunction, oxidative stress and inflammation. Among environmental factors, Vitamin D was reported to associate with the risk of PD. Vitamin D activity is mediated by its binding to the vitamin D Receptor (VDR), a transcriptional factor for almost 3% of human genes. We genotyped for ApaI, BsmI, TaqI, FokI and rs1989969 VDR single ...
Tópico(s): Biotin and Related Studies
2021 - Elsevier BV | Journal of the Neurological Sciences
Luigi Ruffo Codecasa, Nicola Murgia, Maurizio Ferrarese, Monica Delmastro, Alice Claudia Repossi, L Casali, Giorgio Besozzi, Giovanni Ferrara, Mario Raviǵlione,
Villa Marelli Institute (VMI), Niguarda Ca'Granda Hospital, Milan, Italy.A recent report on the fatal side effects of isoniazid preventive therapy (IPT) from the United States has re-ignited discussion on the safety of this intervention.To evaluate IPT feasibility, treatment completion and adverse events (AE) and their determinants under field conditions.Data from consecutive subjects undergoing IPT at the VMI were recorded in an electronic database from 1992 to 2009. Logistic regression analysis was ...
Tópico(s): Infectious Encephalopathies and Encephalitis
2013 - International Union Against Tuberculosis and Lung Disease | The International Journal of Tuberculosis and Lung Disease
Francesco Santini, Gianluca Casali, Gianluigi Franchi, Stefano Auriemma, Mario Lusini, Luca Barozzi, Alessandro Favaro, Antonio Messina, Alessandro Mazzucco,
Tópico(s): Nitric Oxide and Endothelin Effects
2005 - Elsevier BV | International Journal of Cardiology
Christian Casali, Alessandro Stefani, Giulio Rossi, Mario Migaldi, Stefania Bettelli, A Parise, Uliano Morandi,
Large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine tumor of the lung that shares some clinicopathologic and molecular features with small cell lung carcinoma (SCLC). Optimal treatment has not yet been standardized and significant prognostic factors are lacking. Because c-kit protein overexpression has been recently reported as a negative prognostic factor in SCLC we investigated its expression and prognostic value in a series of LCNEC.Resected LCNEC fulfilling the morphologic ...
Tópico(s): Peptidase Inhibition and Analysis
2004 - Elsevier BV | The Annals of Thoracic Surgery
Giulio Rossi, Alberto Cavazza, Alessandro Marchioni, Lucia Longo, Mario Migaldi, Giuliana Sartori, Nazzarena Bigiani, Laura Schirosi, Christian Casali, Uliano Morandi, Nicola Facciolongo, Antonino Maiorana, Mario Bavieri, Leonardo M. Fabbri, Élisabeth Brambilla,
Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a relatively uncommon, high-grade neuroendocrine tumor sharing several features with small-cell lung carcinoma (SCLC) but currently considered as a variant of non-SCLC and accordingly treated with poor results. Little is known about the optimal therapy of LCNEC and the possible therapeutic molecular targets.We reviewed 83 patients with pure pulmonary LCNEC to investigate their clinicopathologic features, therapeutic strategy, and immunohistochemical ...
Tópico(s): Gyrotron and Vacuum Electronics Research
2005 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Florian Bodranghien, Amy J. Bastian, Carlo Casali, Mark Hallett, Elan D. Louis, Mario Manto, Peter Mariën, Dennis A. Nowak, Jeremy D. Schmahmann, Mariano Serrao, Katharina M. Steiner, Michael Strupp, Caroline Tilikete, Dagmar Timmann, Kim van Dun,
The cerebellum is involved in sensorimotor operations, cognitive tasks and affective processes. Here, we revisit the concept of the cerebellar syndrome in the light of recent advances in our understanding of cerebellar operations. The key symptoms and signs of cerebellar dysfunction, often grouped under the generic term of ataxia, are discussed. Vertigo, dizziness, and imbalance are associated with lesions of the vestibulo-cerebellar, vestibulo-spinal, or cerebellar ocular motor systems. The cerebellum ...
Tópico(s): Ophthalmology and Eye Disorders
2015 - Springer Science+Business Media | The Cerebellum
Olivier Bodart, Olivia Gosseries, Sarah Wannez, Aurore Thibaut, Jitka Annen, Mélanie Boly, Mario Rosanova, Adenauer G. Casali, Silvia Casarotto, Giulio Tononi, Marcello Massimini, Steven Laureys,
Making an accurate diagnosis in patients with disorders of consciousness remains challenging. 18F-fluorodeoxyglucose (FDG)–PET has been validated as a diagnostic tool in this population, and allows identifying unresponsive patients with a capacity for consciousness. In parallel, the perturbational complexity index (PCI), a new measure based on the analysis of the electroencephalographic response to transcranial magnetic stimulation, has also been suggested as a tool to distinguish between unconscious ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2017 - Elsevier BV | NeuroImage Clinical
Produção Nacional
Revisado por pares
Alberto Pisoni, Giulia Mattavelli, Costanza Papagno, Mario Rosanova, Adenauer G. Casali, Leonor J. Romero Lauro,
Increasing evidence shows that anodal transcranial direct current stimulation (tDCS) enhances cognitive performance in healthy and clinical population. Such facilitation is supposed to be linked to plastic changes at relevant cortical sites. However, direct electrophysiological evidence for this causal relationship is still missing. Here, we show that cognitive enhancement occurring in healthy human subjects during anodal tDCS is affected by ongoing brain activity, increasing cortical excitability ...
Tópico(s): Vestibular and auditory disorders
2017 - Oxford University Press | Cerebral Cortex
Produção Nacional
Revisado por pares
Simone Sarasso, Mario Rosanova, Adenauer G. Casali, Silvia Casarotto, Matteo Fecchio, Mélanie Boly, Olivia Gosseries, Giulio Tononi, Steven Laureys, Marcello Massimini,
We normally assess another individual’s level of consciousness based on her or his ability to interact with the surrounding environment and communicate. Usually, if we observe purposeful behavior, appropriate responses to sensory inputs, and, above all, appropriate answers to questions, we can be reasonably sure that the person is conscious. However, we know that consciousness can be entirely within the brain, even in the absence of any interaction with the external world; this happens almost every ...
Tópico(s): Traumatic Brain Injury Research
2014 - SAGE Publishing | Clinical EEG and Neuroscience
Giulia Mattavelli, Mario Rosanova, Adenauer G. Casali, Costanza Papagno, Leonor J. Romero Lauro,
Neuroimaging and electrophysiological studies have shown the involvement of a fronto-temporo-occipital network in face processing, but the functional relation among these areas remains unclear. We used transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) to explore the local and global cortical excitability at rest and during two different face processing behavioral tasks. Single-pulse TMS was delivered (100 ms after face stimulus onset) over the right medial prefrontal ...
Tópico(s): Neural and Behavioral Psychology Studies
2013 - Elsevier BV | NeuroImage
Mario Rosanova, Adenauer G. Casali, Valentina Bellina, F. Resta, Maurizio Mariotti, Marcello Massimini,
The frequency tuning of a system can be directly determined by perturbing it and by observing the rate of the ensuing oscillations, the so called natural frequency. This approach is used, for example, in physics, in geology, and also when one tunes a musical instrument. In the present study, we employ transcranial magnetic stimulation (TMS) to directly perturb a set of selected corticothalamic modules (Brodmann areas 19, 7, and 6) and high-density electroencephalogram to measure their natural frequency. ...
Tópico(s): Neural dynamics and brain function
2009 - Society for Neuroscience | Journal of Neuroscience
Giulia Mattavelli, Mario Rosanova, Adenauer G. Casali, Costanza Papagno, Leonor J. Romero Lauro,
Neuroimaging and electrophysiological studies provide evidence of hemispheric differences in processing faces and, in particular, emotional expressions. However, the timing of emotion representation in the right and left hemisphere is still unclear. Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) was used to explore cortical responsiveness during behavioural tasks requiring processing of either identity or expression of faces. Single-pulse TMS was delivered 100ms ...
Tópico(s): Visual perception and processing mechanisms
2016 - Elsevier BV | Brain and Cognition
Produção Nacional
Revisado por pares
Simone Sarasso, Mélanie Boly, Martino Napolitani, Olivia Gosseries, Vanessa Charland‐Verville, Silvia Casarotto, Mario Rosanova, Adenauer G. Casali, J. F. Brichant, Pierre Boveroux, Steffen Rex, Giulio Tononi, Steven Laureys, Marcello Massimini,
A common endpoint of general anesthetics is behavioral unresponsiveness [1Sanders R.D. Tononi G. Laureys S. Sleigh J.W. Unresponsiveness ≠ unconsciousness.Anesthesiology. 2012; 116: 946-959Crossref PubMed Scopus (277) Google Scholar], which is commonly associated with loss of consciousness. However, subjects can become disconnected from the environment while still having conscious experiences, as demonstrated by sleep states associated with dreaming [2Stickgold R. Malia A. Fosse R. Propper R. Hobson ...
Tópico(s): Neural dynamics and brain function
2015 - Elsevier BV | Current Biology
Fabio Guerini, Ettore Beghi, Giulio Riboldazzi, Roberta Zangaglia, C. Pianezzola, G. Bono, Carlo Casali, Cherubino Di Lorenzo, Cristina Agliardi, Giuseppe Nappi, Mario Clerici, E. Martignoni,
Background and purpose: A possible association between Parkinson’s disease (PD) and the polymorphism of Brain Derived Neurotrophic Factor (BDNF) G196A (Val66Met) has been suggested by different studies that nevertheless yielded‐contrasting result. The purpose of this study was to analyze such possible association in a cohort of Italian PD patients. Methods: The BDNF polymorphisms were analyzed in 294 Italian patients with PD; results were compared to those obtained in 233 age‐ and sex‐matched healthy ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2009 - Wiley | European Journal of Neurology
Silvia Stacchiotti, Paolo G. Casali, Salvatore Lo Vullo, Luigi Mariani, Elena Palassini, Mario Mercuri, Marco Alberghini, Silvana Pilotti, Licciana Zanella, Alessandro Gronchi, Piero Picci,
Tópico(s): Oral and Maxillofacial Pathology
2009 - Springer Science+Business Media | Annals of Surgical Oncology
Produção Nacional
Revisado por pares
Rodrigo Parisi Dutra, Daniel Casali, Rafaela Velloso Missagia, Germán Mariano Gasparini, Fernando A. Perini, Mário Alberto Cozzuol,
Tópico(s): Genetic diversity and population structure
2016 - Springer Science+Business Media | Journal of Mammalian Evolution
Maria Elisabetta Zanolin, Cristian Pattaro, Angelo Guido Corsico, Massimiliano Bugiani, Laura Carrozzi, L Casali, Rossano Dallari, Marcello Ferrari, Alessandra Marinoni, Enrica Migliore, Mario Olivieri, Pietro Pirina, Giuseppe Verlato, Simona Villani, Roberto de Marco,
Background: Variations in the prevalence of respiratory symptoms according to geo‐climatic factors could provide important clues to the knowledge of the aetiology of asthma. Methods: Geo‐climatic variations in the prevalence of current asthma, allergic rhinitis and chronic cough, and phlegm were assessed on a random sample of 18 873 subjects (response rate = 72.7%) from different climatic regions of Italy. An ecological analysis, supported by robust statistical methods, was employed to investigate ...
Tópico(s): Air Quality and Health Impacts
2004 - Wiley | Allergy