Jurica Ševa, David Luis Wiegandt, Julian Götze, Mario Lamping, Damian Rieke, Reinhold Schäfer, Patrick Jähnichen, Madeleine Kittner, Steffen Pallarz, Johannes Starlinger, Ulrich Keilholz, Ulf Leser,
Diagnosis and treatment decisions in cancer increasingly depend on a detailed analysis of the mutational status of a patient's genome. This analysis relies on previously published information regarding the association of variations to disease progression and possible interventions. Clinicians to a large degree use biomedical search engines to obtain such information; however, the vast majority of scientific publications focus on basic science and have no direct clinical impact. We develop the Variant- ...
Tópico(s): Bioinformatics and Genomic Networks
2019 - BioMed Central | BMC Bioinformatics
Sandra Wende, Serena Bonin, Otto Götze, Heike Betat, Mario Mörl,
CCA-adding enzymes synthesize and maintain the C-C-A sequence at the tRNA 3′-end, generating the attachment site for amino acids. While tRNAs are the most prominent substrates for this polymerase, CCA additions on non-tRNA transcripts are described as well. To identify general features for substrate requirement, a pool of randomized transcripts was incubated with the human CCA-adding enzyme. Most of the RNAs accepted for CCA addition carry an acceptor stem-like terminal structure, consistent with ...
Tópico(s): RNA Research and Splicing
2015 - Oxford University Press | Nucleic Acids Research
Andrés Folguera, Zuzana Alasonati Tašárová, Hans‐Jürgen Götze, Emilio Rojas Vera, Mario Giménez, Víctor A. Ramos,
The Andean retroarc between 35° and 40°S is the locus of debate regarding its Pliocene to Quaternary tectonic setting. Retroarc volcanic eruptions since 6 Ma to the Present are, based on some hypotheses, associated with widespread extension. In these works, geological data point to the existence of normal faults affecting previous (Late Cretaceous to Miocene) contractional structures. In order to evaluate such interpretations we have collected data from various geological and geophysical studies ...
Tópico(s): High-pressure geophysics and materials
2012 - Elsevier BV | Journal of South American Earth Sciences
Madeleine Kittner, Mario Lamping, Damian Rieke, Julian Götze, Bariya Bajwa, Ivan Jelas, Gina Rüter, Hanjo Hautow, Mario Sänger, Maryam Habibi, Marit Zettwitz, Till de Bortoli, Leonie Ostermann, Jurica Ševa, Johannes Starlinger, Oliver Kohlbacher, Nisar P. Malek, Ulrich Keilholz, Ulf Leser,
Abstract Objective We present the Berlin-Tübingen-Oncology corpus (BRONCO), a large and freely available corpus of shuffled sentences from German oncological discharge summaries annotated with diagnosis, treatments, medications, and further attributes including negation and speculation. The aim of BRONCO is to foster reproducible and openly available research on Information Extraction from German medical texts. Materials and Methods BRONCO consists of 200 manually deidentified discharge summaries ...
Tópico(s): Natural Language Processing Techniques
2021 - University of Oxford | JAMIA Open
Deepak Vangala, Swetlana Ladigan, Sven T. Liffers, Soha Noseir, Abdelouahid Maghnouj, Tina-Maria Götze, Berlinda Verdoodt, Susanne Klein‐Scory, Laura Godfrey, Martina K. Zowada, Mario Huerta, Daniel L. Edelstein, Jaime Martínez de Villarreal, Miriam Marqués, Jörg Kumbrink, Andreas Jung, Tobias S. Schiergens, Jens Werner, Volker Heinemann, Sebastian Stintzing, Doris Lindoerfer, Ulrich Mansmann, Michael Pohl, Christian Teschendorf, Christiane Bernhardt, Heiner Wolters, J. Stern, Selami Usta, Richard Viebahn, Jakob Admard, Nicolas Casadei, Stefan Fröhling, Claudia R. Ball, Jens T. Siveke, Hanno Glimm, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn,
Abstract Background The development of secondary resistance (SR) in metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully understood at the molecular level. Here we tested in vivo selection of anti-EGFR SR tumors in CRC patient-derived xenograft (PDX) models as a strategy for a molecular dissection of SR mechanisms. Methods We analyzed 21 KRAS, NRAS, BRAF, and PI3K wildtype CRC patient-derived xenograft (PDX) models for their anti-EGFR ...
Tópico(s): Genetic factors in colorectal cancer
2021 - BioMed Central | Genome Medicine
Klaus Peseke, Lutz Götze, Helmut Reinke, Quirino Arias Cedeño, José Quincoces Suárez, Mario Gómez Andreu, Hermán Vélez Castro,
Journal für Praktische Chemie/Chemiker-ZeitungVolume 339, Issue 1 p. 656-659 Procedures and DataFull Access A Synthesis of Substituted Tetrahydro-2-pyranols Prof. Dr. Klaus Peseke, Corresponding Author Prof. Dr. Klaus Peseke Rostock, Fachbereich Chemie der UniversitätFachbereich Chemie, Universität Rostock, Buchbinderstr. 9, D-18051 RostockSearch for more papers by this authorLutz Götze, Lutz Götze Rostock, Fachbereich Chemie der UniversitätSearch for more papers by this authorHelmut Reinke, Helmut ...
Tópico(s): Chemical Synthesis and Reactions
1997 - Wiley | Journal für praktische Chemie
Eszter Balogh, Jennifer C. Chandler, Máté Varga, Mona Tahoun, Dóra K. Menyhárd, Gusztáv Schay, Tomas Goncalves, Renáta Hamar, Regina Légrádi, Ákos Szekeres, Olivier Gribouval, Robert Kleta, Horia Stanescu, Detlef Böckenhauer, Andrea Kerti, Hywel Williams, Veronica A. Kinsler, Wei‐Li Di, David Curtis, Maria Kolatsi‐Joannou, Hafsa Hammid, Anna Szőcs, Kristóf Perczel, Erika Maka, Gergely Toldi, Florentina Sava, Christelle Arrondel, Magdolna Kardos, Attila Fintha, Ahmed Hossain, Felipe D’Arco, Marios Kaliakatsos, Jutta Köeglmeier, William Mifsud, Mariya Moosajee, Ana Faro, Eszter Jávorszky, Gábor Rudas, Marwa H. Saied, Salah Marzouk, Kata Kelen, Judit Götze, György Reusz, Tivadar Tulassay, François Dragon, Géraldine Mollet, Susanne Motameny, Hölger Thiele, Guillaume Dorval, Peter Nürnberg, András Perczel, Attila J. Szabó, David A. Long, Kazunori Tomita, Corinne Antignac, Aoife Waters, Kálmán Tory,
RNA modifications play a fundamental role in cellular function. Pseudouridylation, the most abundant RNA modification, is catalyzed by the H/ACA small ribonucleoprotein (snoRNP) complex that shares four core proteins, dyskerin (DKC1), NOP10, NHP2, and GAR1. Mutations in DKC1 , NOP10 , or NHP2 cause dyskeratosis congenita (DC), a disorder characterized by telomere attrition. Here, we report a phenotype comprising nephrotic syndrome, cataracts, sensorineural deafness, enterocolitis, and early lethality in ...
Tópico(s): RNA Research and Splicing
2020 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Pierre Fenaux, Uwe Platzbecker, Ghulam J. Mufti, Guillermo Garcia‐Manero, Rena Buckstein, Valeria Santini, María Díez‐Campelo, Carlo Finelli, Mario Cazzola, Osman İlhan, Mikkael A. Sekeres, José Falantes, Beatriz Arrizabalaga, Flavia Salvi, Valentina Giai, Paresh Vyas, David Bowen, Dominik Selleslag, Amy E. DeZern, Joseph G. Jurcic, Ulrich Germing, Katharina S. Götze, Bruno Quesnel, Odile Beyne‐Rauzy, Thomas Cluzeau, Maria Teresa Voso, Dominiek Mazure, Edo Vellenga, Peter L. Greenberg, Eva Hellström‐Lindberg, Amer M. Zeidan, Abderrahmane Laadem, Aziz Benzohra, Jennie Zhang, Anita Rampersad, Peter G. Linde, Matthew L. Sherman, Rami S. Komrokji, Alan F. List,
Abstract Introduction: MDS is associated with an erythroid maturation defect, characterized by ineffective erythropoiesis leading to anemia and RBC transfusion dependence. Treatment of anemia in lower-risk MDS remains an unmet medical need. Luspatercept is a first-in-class erythroid maturation agent which binds to select TGFβ superfamily ligands to reduce aberrant Smad2/3 signaling and enhance late-stage erythropoiesis (Suragani RN, et al. Nat Med. 2014;20:408-14). Preliminary clinical studies have ...
Tópico(s): Erythrocyte Function and Pathophysiology
2018 - Elsevier BV | Blood
Pierre Fenaux, Uwe Platzbecker, Ghulam J. Mufti, Guillermo Garcia‐Manero, Rena Buckstein, Valeria Santini, María Díez‐Campelo, Carlo Finelli, Mario Cazzola, Osman İlhan, Mikkael A. Sekeres, José Falantes, Beatriz Arrizabalaga, Flavia Salvi, Valentina Giai, Paresh Vyas, David Bowen, Dominik Selleslag, Amy E. DeZern, Joseph G. Jurcic, Ulrich Germing, Katharina S. Götze, Bruno Quesnel, Odile Beyne‐Rauzy, Thomas Cluzeau, Maria-Teresa Voso, Dominiek Mazure, Edo Vellenga, Peter L. Greenberg, Eva Hellström-Lindberg, Amer M. Zeidan, Lionel Adès, Amit Verma, Michael R. Savona, Abderrahmane Laadem, Aziz Benzohra, Jennie Zhang, Anita Rampersad, Diana Dunshee, Peter G. Linde, Matthew L. Sherman, Rami S. Komrokji, Alan F. List,
Patients with anemia and lower-risk myelodysplastic syndromes in whom erythropoiesis-stimulating agent therapy is not effective generally become dependent on red-cell transfusions. Luspatercept, a recombinant fusion protein that binds transforming growth factor β superfamily ligands to reduce SMAD2 and SMAD3 signaling, showed promising results in a phase 2 study.In a double-blind, placebo-controlled, phase 3 trial, we randomly assigned patients with very-low-risk, low-risk, or intermediate-risk ...
Tópico(s): Neutropenia and Cancer Infections
2020 - Massachusetts Medical Society | New England Journal of Medicine
Andrés Folguera, Zuzana Alasonati Tašárová, Hans‐Jürgen Götze, Emilio Rojas Vera, Mario Giménez, Víctor A. Ramos,
Tópico(s): Evolution and Paleontology Studies
2012 - Elsevier BV | Journal of South American Earth Sciences
... 1978. American Journal of Epidemiology, 131, 356– 364. Götze R, Rosenberger G and Ziegenhagen G, 1954. Die ... Klinische Diagnose. Monatshefte fur Veterinarmedizin, 9, 517– 526. Götze R, Rosenberger G and Ziegenhagen G, 1956. Über ...
Tópico(s): Vector-Borne Animal Diseases
2015 - Wiley | EFSA Journal
... org/10.1016/j.jmateco.2014.03.006Uwe Götze Modelle für Programmentscheidungen bei Sicherheit, (Dec 2014): 309– ... 2014).https://doi.org/10.2139/ssrn.2395205Uwe Götze Modelle für Vorteilhaftigkeitsentscheidungen bei einer Zielgröße, (Dec 2014): ... j.1465-7287.2007.00068.xFrank Mrusek, Uwe Götze Zur Bestimmung der optimalen Rotationsperiode in der Forstwirtschaft, ( ...
Tópico(s): Business, Education, Mathematics Research
1958 - University of Chicago Press | Journal of Political Economy
Adolfo de Salazar, Julia Dietz, V.C. Di Maio, Johannes Vermehren, Stefania Paolucci, Beat Müllhaupt, Nicola Coppola, Joaquín Cabezas, Rudolf Stauber, Massimo Puoti, Juan Ignacio Arenas Ruiz Tapiador, Christiana Graf, M. Aragri, Miguel A. Jiménez, Annapaola Callegaro, Juan Manuel Pascasio Acevedo, Manuel Alberto Macías Rodríguez, José Miguel Rosales Zábal, Valeria Micheli, Miguel García Deltoro, Francisco Téllez, Féderico García, Christoph Sarrazin, Francesca Ceccherini‐Silberstein, Tobias Götze, Ali Canbay, Kerstin Port, Markus Cornberg, Michael Manns, Lars Reinhardt, Volker Ellenrieder, Eugen Zizer, Nektarios Dikopoulos, Johanna Backhus, Thomas Seufferlein, Susanne Beckebaum, S Hametner, R Schöfl, Claus Niederau, P. Schlee, M. Dreck, B. Görlitz, Holger Hinrichsen, Barbara Seegers, M. Jung, R. Link, Stefan Mauss, V. Meister, Eiko Schnaitmann, C. Sick, Karl‐Georg Simon, K. J. Schmidt, Massimo Andreoni, Antonio Craxı̀, P. Giaccone, Carlo Federico Perno, Maurizio Zazzi, Ada Bertoli, M. Angélico, Chiara Masetti, V. Giannelli, San Camillo, Paola Begini, A. De Santis, Gloria Taliani, Miriam Lichtner, Barbara Rossetti, C. Caudai, Raffaele Cozzolongo, S De Bellis, Mario Starace, Carmine Minichini, Gianfranco Gaeta, Mariantonietta Pisaturo, Vincenzo Messina, Chiara Dentone, Bianca Bruzzone, Simona Landonio, C. Magni, Marco Merli, Elisabetta De Gasperi, Granda Ospedale Maggiore Policlinico, Hamid Hasson, Enzo Boeri, Ilaria Beretta, Chiara Molteni, A Manzoni Elena Maffezzini, Nicoletta Dorigoni, Lorenza Guella, Tobias Götze, Ali Canbay, Kerstin Port, Markus Cornberg, Michael Manns, Lars Reinhardt, Volker Ellenrieder, Eugen Zizer, Nektarios Dikopoulos, Johanna Backhus, Thomas Seufferlein, Susanne Beckebaum, S Hametner, R Schöfl, Claus Niederau, P. Schlee, M. Dreck, B. Görlitz, Holger Hinrichsen, Barbara Seegers, M. Jung, R. Link, Stefan Mauss, V. Meister, Eiko Schnaitmann, C. Sick, Karl‐Georg Simon, K. J. Schmidt, Massimo Andreoni, Antonio Craxı̀, P. Giaccone, Carlo Federico Perno, Maurizio Zazzi, Ada Bertoli, M. Angélico, Chiara Masetti, V. Giannelli, San Camillo, Paola Begini, A. De Santis, Gloria Taliani, Miriam Lichtner, Barbara Rossetti, C. Caudai, Raffaele Cozzolongo, S De Bellis, Mario Starace, Carmine Minichini, Gianfranco Gaeta, Mariantonietta Pisaturo, Vincenzo Messina, Chiara Dentone, Bianca Bruzzone, Simona Landonio, C. Magni, Marco Merli, Elisabetta De Gasperi, Granda Ospedale Maggiore Policlinico, Hamid Hasson, Enzo Boeri, Ilaria Beretta, Chiara Molteni, A Manzoni Elena Maffezzini, Nicoletta Dorigoni, Lorenza Guella,
Abstract Objectives To investigate resistance-associated substitutions (RASs) as well as retreatment efficacies in a large cohort of European patients with failure of glecaprevir/pibrentasvir. Methods Patients were identified from three European Resistance Reference centres in Spain, Italy and Germany. Sequencing of NS3, NS5A and NS5B was conducted and substitutions associated with resistance to direct antiviral agents were analysed. Clinical and virological parameters were documented retrospectively ...
Tópico(s): HIV Research and Treatment
2020 - Oxford University Press | Journal of Antimicrobial Chemotherapy
... Rüdiger Stephan GÖRTZ, Daniel GOTTHARDT, Martin GÖTZ, Oliver GÖTZE, Thorsten GÖTZE, Marian GRADE, Christiana GRAF, Ingo GRÄFF, Lars GRENACHER, ...
Tópico(s): Health and Medical Studies
2018 - Thieme Medical Publishers (Germany) | Zeitschrift für Gastroenterologie